16 November, 2024
    Tshuaj Kho Mob

    Kev txheeb xyuas rau Rosucard

    Cov khoom siv tseem ceeb ntawm Rosucard yog rosuvastatin. Feem ntau cov nyhuv ntawm cov tshuaj tshwm sim nyob rau hauv daim siab - lub ntsiab hloov khoom nruab nrog rau kev sib txuas ntawm cov cholesterol. Rosucard txo qis qib uas tsis muaj cov lipoproteins tsawg (LDL), uas yog, "cov" roj cholesterol "tsis zoo thiab nce qib" cov roj "zoo" (HDL - high lipoproteins).

    Ib lub lis piam tom qab pib noj Rosucard, nws txoj kev kho kom zoo tshwm sim. Kev txhim kho siab tshaj plaws tuaj yeem ua tiav ob lub lis piam tom qab pib kho mob nrog Rosucard. Txhawm rau kom ua tiav txoj haujlwm ntev, hom kev kho mob yuav tsum yog tsawg kawg yog ib hlis.

    Cov lus qhia rau kev siv Rosucard yog:

    • thawj hypercholesterolemia,
    • tov dyslipidemia,
    • mob rwj hypercholisterinemia,
    • atherosclerosis.

    Tsis tas li, cov tshuaj tau raug txwv kom tiv thaiv kev txhim kho ntawm cov kab mob plawv hauv cov neeg mob uas muaj pheej hmoo.

    Ib qhov tshwj xeeb ntawm kev siv Rosucard yog tias ua ntej pib siv tshuaj, tus neeg mob yuav tsum pib ua raws cov zaub mov noj tsawg thiab ua raws li nws thoob plaws lub sijhawm kho. Raws li cov lus qhia, Rosucard tuaj yeem siv tau txhua lub sijhawm ntawm hnub, tsis hais noj zaub mov.

    Cov koob tshuaj ntawm cov tshuaj yog xaiv los ntawm tus kws kho mob ib leeg zuj zus, suav txog lub hom phiaj thiab kev xav ntawm tus neeg mob. Feem ntau, qhov pib ntawm Rosucard yog 10 mg. Tom qab ib hlis, nws tuaj yeem nce ntxiv rau 20 mg. Hauv cov teeb meem tshwj xeeb tshaj yog, 40 mg ntawm Rosucard yog cov kws kho mob. Cov tshuaj yog contraindicated rau hauv cov menyuam yaus hnub nyoog qis dua 10 xyoo.

    Hauv kev coj ntawm Rosucard, qee qhov kev mob tshwm sim tuaj yeem pom. Yog li tawm tsam nws cov keeb kwm yav dhau los kiv taub hau thiab mob taub hau, tsis xis nyob ntawm txoj hnyuv plab, uas yog mob plab, xeev siab, cem quav, ua xua dermatitis, feem ntau sau tseg. Tsis tshua muaj neeg pom yog pw tsaug zog, nrog rau cov txheej txheem ua rau daim siab - mob siab. Sab nyhuv ntawm Rosucard, raws li txoj cai, yog koob tshuaj-siv.

    Cov kev rau noj Rosucard yog:

    • ib tug neeg intolerance,
    • ntau cov kab mob siab, nrog rau cov ntshav siab transaminase nce siab,
    • mob raum
    • noj tshuaj cyclosporine
    • cev xeeb tub thiab lactation,
    • myopathies.

    Nrog rau kev saib xyuas tshwj xeeb, Rosucard tau raug muab rau cov neeg mob ntawm cov haiv neeg Asian lossis laus dua 70 xyoo, thiab nrog rau hypothyroidism, cawv, kho nrog fibrates thiab tom qab kab mob leeg. Thaum noj cov tshuaj Rosucard, cov neeg muaj ntshav qabzib muaj feem yuav ua ntshav qab zib.

    Hauv cov pawg ntawm cov neeg mob no, ua ntej sau ntawv rau Rosucard, nws yog qhov tsim nyog los sib piv cov kev pheej hmoo uas twb muaj lawm thiab cov txiaj ntsig kho kwv yees tau. Thaum muab tshuaj rau lawv, nws raug nquahu tias kev kho mob yuav tsum tau nqa tawm hauv tsev kho mob hauv kev saib xyuas kev kho mob tas mus li.

    Ua ntej pib txoj kev kho mob nrog Rosucard, cov neeg mob tau ceeb toom txog qhov yuav tsum tau qhia rau tus kws kho mob uas tuaj kawm txog qhov tsos mob ntawm cov leeg mob, mob plab, tsis muaj zog, tshwj xeeb tshaj yog nrog kev mob tsis txaus thiab hyperthermia. Kev txiav txim siab thim lossis txuas ntxiv mus siv cov tshuaj yog txiav txim siab ntawm cov ntaub ntawv hauv chaw kuaj.

    Cov lus qhia ntawm Rosucard

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 54 rubles. Cov analogue yog pheej yig dua los ntawm 811 rubles

    Qhov sib tw raws cov cim

    Nqe los ntawm 324 rubles. Cov analogue yog pheej yig dua los ntawm 541 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 345 rubles. Cov analogue yog pheej yig dua los ntawm 520 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 369 rubles. Cov analogue yog pheej yig dua los ntawm 496 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 418 rubles. Cov analogue yog pheej yig dua los ntawm 447 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 438 rubles. Cov analogue yog pheej yig dua los ntawm 427 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 604 rubles. Cov analogue yog pheej yig dua los ntawm 261 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 660 rubles. Cov pev txig yog cov pheej yig los ntawm 205 rubles

    Qhov sib tw raws cov cim

    Tus nqi yog los ntawm 737 rubles. Cov analogue yog pheej yig dua los ntawm 128 rubles

    Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

    Zaj duab xis-coated ntsiav tshuaj lub teeb paj yeeb, oblong, biconvex, nrog kev pheej hmoo.

















    1 tab
    rosuvastatin calcium 10,4 mg
    uas sib haum rau cov ntsiab lus ntawm rosuvastatin 10 mg

    Cov tub ntxhais: cov lactose monohydrate - 60 mg, microcrystalline cellulose - 45.4 mg, croscarmellose sodium - 1.2 mg, colloidal silicon dioxide - 600 μg, magnesium stearate - 2.4 mg.

    Muaj pes tsawg leeg zaj duab xis plhaub: hypromellose 2910/5 - 2.5 mg, macrogol 6000 - 400 μg, titanium dioxide - 325 μg, talc - 475 μg, hlau zas xim liab oxide - 13 μg.

    10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.
    10 Pcs - hlwv (6) - pob khoom los ntawm cardboard.
    10 Pcs - hlwv (9) - pob khoom los ntawm cardboard.

    Pharmacological kev txiav txim

    Hypolipidemic tshuaj los ntawm pab pawg neeg ntawm statins. Xaiv kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov HMG-CoA rau mevalonate, ib qho ua ntej ntawm cov roj (Ch).

    Nce tus naj npawb ntawm LDL receptors nyob rau saum npoo ntawm hepatocytes, uas ua rau kom muaj kev nce siab thiab catabolism ntawm LDL, inhibition of VLDL synthesis, txo tag nrho cov ntsiab lus ntawm LDL thiab VLDL. Txo qhov kev tso cia ntawm LDL-C, HDL cov roj cholesterol-tsis-lipoproteins (HDL-tsis-HDL), HDL-V, tag nrho Xc, TG, TG-VLDL, apolipoprotein B (ApoV), txo qis piv ntawm LDL-C / Lc-HDL, tag nrho Xc / Xl HDL-C, Chs-tsis yog HDL-C / HDL-C, ApoB / apolipoprotein A-1 (ApoA-1), ua rau muaj zog ntau ntawm HDL-C thiab ApoA-1.

    Kev lipid-txo cov nyhuv yog ncaj qha ncaj qha rau cov koob tshuaj uas tau xaj tshuaj. Kev kho mob tshwm sim nyob rau hauv 1 lub lis piam tom qab pib kho, tom qab 2 lub lis piam nce mus txog 90% ntawm qhov siab tshaj plaws, nce mus txog qhov siab kawg los ntawm 4 lub lis piam thiab tom qab ntawd mus tas li.

    Cov lus 1. Txaus siab-qhov cuam tshuam cov neeg mob hauv cov neeg mob thawj hom hypercholesterolemia (hom IIa thiab IIb raws li kev faib tawm ntawm Fredrickson) (qhov ntsuas nruab nrab tau hloov pauv feem ntau piv rau tus nqi pib)
















































































    Koob tshuaj Tus naj npawb ntawm cov neeg mob HS-LDL Tag nrho Chs HS-HDL
    Tso cov tshuaj 13 -7 -5 3
    10 mg 17 -52 -36 14
    20 mg 17 -55 -40 8
    40 mg 18 -63 -46 10
    Koob tshuaj Tus naj npawb ntawm cov neeg mob TG Xc-
    tsis-HDL    		 Apo v Apo AI
    Tso cov tshuaj 13 -3 -7 -3 0
    10 mg 17 -10 -48 -42 4
    20 mg 17 -23 -51 -46 5
    40 mg 18 -28 -60 -54 0

    Cov lus 2. Qhia txog kev noj tshuaj ntau ntxiv rau cov neeg mob hypertriglyceridemia (hom IIb thiab IV raws li Fredrickson kev faib tawm) (qhov feem pua ​​hloov pauv piv rau tus nqi thaum pib)
















































































    Koob tshuaj Tus naj npawb ntawm cov neeg mob TG HS-LDL Tag nrho Chs
    Tso cov tshuaj 26 1 5 1
    10 mg 23 -37 -45 -40
    20 mg 27 -37 -31 -34
    40 mg 25 -43 -43 -40
    Koob tshuaj Tus naj npawb ntawm cov neeg mob HS-HDL Xc-
    tsis-HDL    		 Xc-
    VLDL    		 TG-
    VLDL
    Tso cov tshuaj 26 -3 2 2 6
    10 mg 23 8 -49 -48 -39
    20 mg 27 22 -43 -49 -40
    40 mg 25 17 -51 -56 -48

    Cov chaw kho mob ua tau

    Ua tau zoo rau cov neeg mob cov neeg laus uas muaj hypercholesterolemia nrog lossis tsis muaj hypertriglyceridemia, tsis hais haiv neeg twg, poj niam lossis txiv neej, incl. hauv cov neeg mob ntshav qab zib mellitus thiab tsev neeg hypercholesterolemia. Hauv 80% ntawm cov neeg mob uas muaj hom IIa thiab IIb hypercholesterolemia (raws li Fredrickson kev faib tawm) nrog qhov pib nruab nrab ntawm LDL-C txog 4.8 mmol / L, thaum noj cov tshuaj ntawm 10 mg, qhov siab ntawm LDL-C nce mus txog tsawg dua 3 mmol / L.

    Hauv cov neeg mob mob heterozygous tsev neeg hypercholesterolemia tau txais rosuvastatin ntawm ib koob ntawm 20-80 mg / hnub, qhov pom qhov zoo ntawm daim lipid profile tau pom. Tom qab ua ntawv xaj rau ib koob tshuaj 40 mg txhua hnub (12 lub lim tiam ntawm txoj kev kho), qhov txo qis hauv kev mloog zoo ntawm LDL-C los ntawm 53% tau sau tseg. Hauv 33% ntawm cov neeg mob, ib qho LDL-C concentration ntawm tsawg dua 3 mmol / L tau tiav.

    Hauv cov neeg mob uas muaj homozygous tsev neeg hypercholesterolemia tau txais cov tshuaj rosuvastatin ntawm ib koob ntawm 20 mg thiab 40 mg, qhov nruab nrab txo hauv qhov kev nkag siab ntawm LDL-C yog 22%.

    Hauv cov neeg mob hypertriglyceridemia nrog kev pib ntawm TG los ntawm 273 mg / dL rau 817 mg / dL, tau txais rosuvastatin hauv koob tshuaj 5 mg txog 40 mg 1 zaug / hnub rau 6 lub lis piam, qhov siab ntawm TG hauv cov ntshav ntshav tau txo qis (saib cov lus 2 )

    Ib qho kev tiv thaiv ntxiv tau pom nyob rau hauv kev sib xyaw nrog fenofibrate nyob rau hauv kev sib raug zoo nrog cov concentration ntawm TG thiab nrog nicotinic acid nyob rau hauv lipid txo cov koob tshuaj (ntau dua 1 g / hnub) hauv kev sib piv rau qhov kev nkag siab ntawm HDL-C.

    Hauv txoj kev tshawb nrhiav METEOR, rosuvastatin txoj kev kho mob ua rau qeeb tus nqi zuj zus ntawm qhov siab tshaj plaws tuab ntawm intima-media complex (TCIM) rau 12 ntu ntawm cov carotid artery piv nrog cov placebo. Piv nrog rau qhov tseem ceeb hauv pawg rosuvastatin, qhov txo qis ntawm qhov siab tshaj plaws TCIM los ntawm 0.0014 hli / xyoo tau muab piv nrog qhov nce ntawm qhov ntsuas no los ntawm 0.0131 hli / xyoo hauv pawg placebo. Txog hnub, txoj kev sib raug zoo ntawm kev txo qis hauv TCIM thiab qhov kev txo qis hauv qhov pheej hmoo ntawm cov hlab plawv tshwm sim tsis tau pom.

    Cov txiaj ntsig ntawm JUPITER tau qhia tias rosuvastatin txo qis txoj kev pheej hmoo ntawm kev txhim kho cov hlab plawv mob nrog qhov kev pheej hmoo ntawm txheeb ze ntawm 44%. Qhov ua tau zoo ntawm kev kho mob tau sau tseg tom qab thawj 6 lub hlis ntawm kev siv tshuaj. Muaj cov ntsiab lus tseem ceeb txo qis ntawm 48% hauv cov qauv ua ke, suav nrog kev tuag los ntawm kev mob plawv, mob ntshav hlab ntsha thiab myocardial infarction, muaj 54% tsawg dua ntawm qhov tshwm sim ntawm kev tuag lossis tsis mob ntshav myocardial infarction, thiab 48% txo qis dua qhov tuag taus lossis tsis tuag. Txhua tus neeg ua haujlwm ploj tuag txog 20% ​​nyob rau hauv pab pawg rosuvastatin. Cov ntaub ntawv kev nyab xeeb hauv cov neeg mob noj 20 mg rosuvastatin feem ntau zoo ib yam li daim ntawv muaj kev nyab xeeb hauv cov pab pawg placebo.

    Cov Tshuaj Pharmacokinetics

    Tom qab noj cov tshuaj hauv Cmax plasma rosuvastatin mus txog hauv 5 teev li. Kev noj qab haus huv ntawm lub cev muaj peev xwm yog txog 20%.

    Kev khi rau cov ntshav plasma protein (feem ntau nrog albumin) yog kwv yees li 90%. Vd - 134 l.

    Rosuvastatin feem ntau yog nqus los ntawm lub siab, uas yog lub vev xaib tseem ceeb rau cov synthes ntawm Chs thiab cov metabolism hauv Chs-LDL.

    Nkag tau los ntawm thaj chaw siab.

    Biotransformed nyob rau hauv daim siab ua ib feem tsawg (kwv yees li 10%), yog qhov tsis yog tub ntxhais hauv av rau isoenzymes ntawm cytochrome P450 system.

    Lub ntsiab isoenzyme koom nrog hauv cov metabolism hauv rosuvastatin yog isoenzyme CYP2C9. Isoenzymes CYP2C19, CYP3A4 thiab CYP2D6 tsawg koom nrog cov metabolism.

    Lub ntsiab metabolites ntawm rosuvastatin yog N-dismethyl thiab lactone metabolites. N-dismethyl yog kwv yees li 50% tsis tshua muaj siab tshaj li rosuvastatin, lactone metabolites yog cov tshuaj pharmacologically tsis voos. Ntau tshaj li 90% ntawm pharmacological kev ua ub no hauv inhibiting ncig HMG-CoA reductase yog muab los ntawm rosuvastatin, qhov seem yog metabolites.

    Xws li lwm yam HMG-CoA reductase inhibitors, cov khoom tshwj xeeb daim nyias nyias yog koom nrog hauv cov txheej txheem ntawm hepatic uptake ntawm cov tshuaj - ib qho polypeptide thauj cov organic anion (OATP) 1B1, uas ua lub luag haujlwm tseem ceeb hauv nws cov kev kho mob hepatic.

    T1/2 - txog 19 teev, tsis hloov nrog ua kom ntau dua. Qhov ntsuas ntshav ntshav nruab nrab yog kwv yees li 50 l / h (coefficient ntawm kev hloov pauv 21.7%). Kwv yees li 90% ntawm qhov koob tshuaj rosuvastatin yog raug hloov pauv tsis tau hloov los ntawm txoj hnyuv, qhov seem los ntawm lub raum.

    Kev raug rau lub cev zuj zus ntawm rosuvastatin nce ntxiv hauv kev faib ua feem.

    Cov chaw muag tshuaj tsis hloov pauv nrog kev siv txhua hnub.

    Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

    Hauv cov neeg mob uas mob mentsis mus rau lub raum tsis ua haujlwm, lub plasma ntshav ntawm rosuvastatin lossis N-dysmethyl tsis hloov pauv ntau. Hauv cov neeg mob uas lub raum tsis txaus (CC tsawg dua 30 ml / min), qhov kev tso tshuaj ntawm rosuvastatin hauv cov ntshav ntshav yog 3 zaug dua, thiab N-dismethyl yog 9 zaug ntau dua ntawm cov neeg ua haujlwm noj qab haus huv. Lub plasma concentration ntawm rosuvastatin hauv cov neeg mob ntawm hemodialysis yog kwv yees li 50% siab dua hauv cov neeg ua haujlwm noj qab haus huv.

    Hauv cov neeg mob uas lub siab tsis ua haujlwm ntawm 7 cov qhab nia lossis qis dua ntawm qhov Child-Pugh nplai, tsis muaj qhov nce hauv T1/2 rosuvastatin, hauv cov neeg mob uas muaj lub siab tsis ua haujlwm 8 thiab 9 ntawm Child-Pugh nplai, qhov elongation ntawm T tau sau tseg1/2 2 zaug. Tsis muaj kev paub dhau los ntawm kev siv cov tshuaj hauv cov neeg mob uas muaj lub siab ua rau lub siab ua haujlwm hnyav dua.

    Poj niam txiv neej thiab lub hnub nyoog tsis muaj kev xav paub pom tseeb hauv lub chaw muag tshuaj ntawm rosuvastatin.

    Cov tshuaj pharmacokinetic ntawm rosuvastatin nyob ntawm seb haiv neeg twg. AUC ntawm cov neeg sawv cev ntawm haiv neeg Mongoloid (Nyiv, Suav, Filipis, Nyablaj thiab Kauslim) yog 2 npaug ntau dua li ntawm haiv neeg Caucasian. Isdias neeg nruab nrab yog AUC thiab Cmax nce li ntawm 1.3 npaug.

    HMG-CoA reductase inhibitors, suav nrog rosuvastatin khi rau cov thauj cov protein OATP1B1 (cov organic anion thauj polypeptide koom nrog hepatocyte uptake ntawm statins) thiab BCRP (efflux transporter). Tus neeg nqa khoom ntawm genotypes SLCO1B1 (OATP1B1) s.521CC thiab ABCG2 (BCRP) s.421AA pom tias muaj kev nce ntxiv (AUC) rau rosuvastatin 1.6 thiab 2.4 npaug, ntsig txog, piv nrog cov nqa ntawm genotypes SLCO1B1 s.521TT thiab ABCG2 s.421CC.

    - thawj hypercholesterolemia (hom IIa raws li Fredrickson), suav nrog kev mob heterozygous hypercholesterolemia lossis sib xyaw hypercholesterolemia (hom IIb raws li Fredrickson) - ntxiv rau kev noj zaub mov, thaum noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis zoo ntawm kev kho mob (piv txwv li kev tawm dag zog lub cev, poob phaus) tsis muaj txhij txhua.

    - tsev neeg homozygous hypercholesterolemia - raws li kev txhawb rau kev noj zaub mov noj thiab lwm txoj kev kho lipid-piv txwv (piv txwv li LDL-apheresis), lossis nyob rau kis uas qhov kev kho no tsis muaj txiaj ntsig txaus,

    - hypertriglyceridemia (yam IV raws Fredrickson) - ntxiv rau kev noj haus,

    - kom maj mam hloov zuj zus ntawm atherosclerosis - ntxiv rau kev noj zaub mov noj hauv cov neeg mob uas pom tias muaj kev kho mob kom txo tau qhov mob ntau ntawm Chs thiab Chs-LDL,

    - kev tiv thaiv thawj ntawm cov kev mob plawv tseem ceeb (mob hlab ntsha tawg, plawv nres, hloov hlab plawv) hauv cov neeg mob cov neeg laus uas tsis muaj cov cim kev mob ntshav siab, tab sis nrog kev pheej hmoo ntawm nws txoj kev loj hlob (ntau dua 50 xyoo rau cov txiv neej thiab ntau dua 60 xyoo rau cov poj niam, nce concentration ntawm C-reactive protein) (≥ 2 mg / l) nyob rau ntawm qhov tsawg kawg ib qho ntawm cov teeb meem pheej hmoo ntxiv, xws li mob ntshav siab, ntshav qis ntawm HDL-C, haus luam yeeb, tsev neeg keeb kwm ntawm qhov pib ntawm CHD).

    Kev noj tshuaj ntxiv

    Cov tshuaj tau noj ntawm qhov ncauj. Cov ntsiav tshuaj yuav tsum tau nqos tag nrho, tsis tas yuav zom thiab tsis zom, ntxhua nrog dej, txhua lub sijhawm ntawm hnub, tsis hais txog ntawm cov khoom noj.

    Ua ntej pib txoj kev kho mob nrog Rosucard ®, tus neeg mob yuav tsum pib ua raws li kev noj cov zaub mov lipid thiab txo qis ua raws nws thaum kho.

    Cov koob tshuaj ntawm cov tshuaj yuav tsum tau xaiv ib tus zuj zus nyob ntawm qhov ntsuas thiab kho qhov lus teb, suav txog qhov tam sim no feem ntau lees txais cov lus pom zoo rau lub hom phiaj lipid ntau.

    Qhov pom zoo kom pib txhaj tshuaj ntawm Rosucard ® rau cov neeg mob pib noj cov tshuaj, lossis rau cov neeg mob hloov mus los ntawm kev noj lwm qhov HMG-CoA reductase inhibitors, yog 5 lossis 10 mg 1 zaug / hnub.

    Thaum xaiv cov tshuaj xub thawj, ib qho yuav tsum tau coj los ntawm tus neeg mob cov ntsiab lus roj thiab coj mus rau hauv qhov kev pheej hmoo ntawm kev tsim cov hlab plawv mob, thiab nws tseem yuav tsum tau soj ntsuam qhov muaj feem ntawm kev phiv tshuaj. Yog tias tsim nyog, tom qab 4 lub lis piam koob tshuaj yuav raug nce siab.

    Vim tias txoj kev txhim kho muaj cov kev mob tshwm sim thaum noj cov tshuaj ntawm koob tshuaj 40 mg, piv nrog cov tshuaj qis dua, qhov kev txiav txim siab zaum kawg rau kev noj tshuaj ntau tshaj 40 mg yuav tsum tau nqa tawm tsuas yog nyob hauv cov neeg mob hypercholesterolemia thiab muaj kev pheej hmoo ntawm cov hlab plawv mob hnyav (tshwj xeeb tshaj yog rau cov neeg mob) nrog cov kab mob hypercholesterolemia), hauv uas thaum noj cov tshuaj ntawm ib koob tshuaj 20 mg, qib roj cholesterol tsis tiav. Cov neeg mob zoo li no yuav tsum muaj kev saib xyuas mob nkeeg. Pom zoo tshwj xeeb kev saib xyuas ntawm cov neeg mob tau txais cov tshuaj hauv ib koob tshuaj 40 mg yog pom zoo.

    Kev noj tshuaj ntawm 40 mg tsis pom zoo rau cov neeg mob uas tsis tau mus ntsib kws kho mob dhau los. Tom qab 2-4 lub lis piam ntawm kev kho mob thiab / lossis nrog kev nce ntxiv ntawm koob tshuaj Rosucard ®, nws yog qhov yuav tsum tau soj ntsuam lipid metabolism (kev kho tshuaj yog tsim nyog yog tias tsim nyog).

    Ntawm cov neeg laus laus dua 65 xyoos Tsis tas yuav txhaj koob tshuaj.

    Ntawm cov neeg mob mob siab tsis ua hauj lwm nrog qhov tseem ceeb hauv qab 7 cov qhab nia ntawm Child-Pugh nplai koob tshuaj hloov kho ntawm Rosucard yog tsis xav tau.

    Ntawm cov neeg mob uas lub raum tsis ua haujlwmKoob tshuaj txhaj tshuaj Rosucard ® tsis tas yuav tsum tau txhaj, qhov kev pom zoo thawj zaug ntawm 5 mg / hnub yog qhov pom zoo. Ntawm cov neeg mob uas tsis tshua mob raum (CC 30-60 ml / min) kev siv cov tshuaj Rosucard ® ntawm ib koob ntawm 40 mg / hnub yog contraindicated. Ntawm mob raum tsis ua haujlwm (CC tsawg dua 30 ml / min) Kev siv cov tshuaj Rosucard ® yog contraindicated.

    Ntawm cov neeg mob nrog lub siab tsis txaus mus rau myopathy kev siv cov tshuaj Rosucard ® ntawm ib koob ntawm 40 mg / hnub yog contraindicated. Thaum muab tshuaj rau hauv cov tshuaj ntawm 10 mg thiab 20 mg / hnub, qhov pom zoo thawj zaug rau pawg neeg mob no yog 5 mg / hnub.

    Thaum kawm txog cov tshuaj pharmacokinetic ntawm rosuvastatin, qhov nce ntawm cov tshuaj muaj zog hauv cov tshuaj nyob rau hauv cov neeg sawv cev tau sau tseg Moob LeegCov. Qhov tseeb no yuav tsum raug coj los txiav txim thaum sau ntawv rau Rosucard ® rau cov neeg mob ntawm haiv neeg Mongoloid. Thaum muab tshuaj rau hauv cov tshuaj ntawm 10 mg thiab 20 mg, qhov pom zoo thawj zaug rau pawg neeg no yog 5 mg / hnub. Kev siv cov tshuaj Rosucard ® ntawm ib koob ntawm 40 mg / hnub nyob rau hauv cov neeg sawv cev ntawm haiv neeg Mongoloid yog contraindicated.

    Caj ces polymorphism. Tus neeg nqa khoom ntawm genotypes SLCO1B1 (OATP1B1) c.521CC thiab ABCG2 (BCRP) c.421AA pom tias muaj kev nce ntxiv (AUC) ntawm rosuvastatin piv nrog cov nqa khoom ntawm genotypes SLC01B1 s.521TT thiab ABCG2 s.421CC. Rau cov neeg mob nqa tshuaj genotypes c.521SS lossis c.421AA, qhov pom zoo tshaj plaws ntawm Rosucard ® yog 20 mg / hnub.

    Kho sab nraud. Rosuvastatin khi rau ntau cov thauj cov protein (tshwj xeeb, OATP1B1 thiab BCRP). Thaum cov tshuaj Rosucard ® tau siv ua ke nrog cov tshuaj (xws li cyclosporine, qee qhov HIV tiv thaiv kab mob tiv thaiv, suav nrog kev sib xyaw ntawm ritonavir nrog atazanavir, lopinavir thiab / lossis tipranavir), uas ua rau muaj kev nce siab ntawm rosuvastatin hauv ntshav ntshav vim muaj kev cuam tshuam nrog kev thauj cov protein, txoj kev pheej hmoo ntawm myopathy yuav nce ntxiv. (suav nrog rhabdomyolysis). Hauv cov xwm txheej zoo li no, koj yuav tsum tau soj ntsuam qhov ua tau los ntawm kev muab tshuaj los kho lwm txoj kev kho lossis txiav ib ntus kev siv Rosucard temporarily. Yog tias kev siv cov tshuaj saum toj no tsim nyog, koj yuav tsum paub koj tus kheej txog cov lus qhia rau kev siv cov tshuaj ua ntej kom kho lawv ib txhij nrog Rosucard ®, ntsuas qhov txiaj ntsig kev pheej hmoo ntawm kev sib txuam nrog kev kho mob thiab txiav txim siab txo qhov tshuaj ntawm Rosucard ®.

    Sab sij huam

    Cov kev phiv uas pom nrog rosuvastatin feem ntau yog mob me thiab ploj mus lawv tus kheej. Raws li nrog lwm HMG-CoA reductase inhibitors, qhov tshwm sim ntawm cov kev mob tshwm sim yog feem ntau koob tshuaj.

    Hauv qab no yog daim ntawv qhia txog qhov tshwm sim tsis zoo rau rosuvastatin, raws li cov ntaub ntawv los ntawm cov kev tshawb fawb soj ntsuam thiab kev nthuav dav tom qab cuv npe.

    Kev txiav txim siab ntawm ntau zaus cov kev mob tshwm sim (WHO kev faib tawm): ntau zaus (> 1/10), feem ntau (los ntawm> 1/100 txog 1/1000 txog 1/10 000 txog 20 mg / hnub), tsis tshua muaj tshwm sim - arthralgia, tendopathy, tej zaum nrog tendon rupture, qhov ntau zaus tsis tau paub - immuno-mediated necrotizing myopathy.

    Kev tsis haum tshuaj: tsis ncau - khaus ntawm daim tawv nqaij, urticaria, tawm pob, tsis tshua muaj - kev ua kom lub siab ntev, suav nrog mob hlwb.

    Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: qhov tsis paub ntau zaus - Stevens-Johnson syndrome.

    Los ntawm cov kab mob urinary: feem ntau - proteinuria, tsis tshua muaj - hematuria. Kev hloov pauv ntawm cov protein nyob hauv cov zis (txij li qhov tsis qhaj lossis tus lej rau ++ lossis ntau dua) tau pom nyob hauv tsawg dua 1% ntawm cov neeg mob tau txais koob tshuaj 10-20 mg / hnub, thiab kwv yees li 3% ntawm cov neeg mob tau txais 40 mg / hnub. Proteinuria tsawg dua thaum kho thiab tsis cuam tshuam nrog qhov tshwm sim ntawm mob raum lossis mob txeeb zig.

    Los ntawm cov qau thiab cov qog mammary: tsis tshua muaj heev - gynecomastia.

    Kev ntsuas ntsuas: nkag tsis tau - qhov ntau ntxiv koob tshuaj tiv thaiv kab mob ntshav ntawm CPK kev ua ub no (feem ntau, tsis txaus ntseeg, asymptomatic thiab ib ntus). Nrog kev nce ntau dua 5 zaug piv nrog VGN, kev kho mob nrog Rosucard ® yuav tsum raug ncua ib ntus. Nce ntshav glycosylated hemoglobin concentration.

    Lwm yam: feem ntau - asthenia, tsis paub ntau zaus - peripheral edema.

    Thaum siv Rosucard ®, kev hloov pauv tau sau nyob rau hauv chav ntsuas hauv qab no: kev nce siab ntawm cov piam thaj, bilirubin, alkaline phosphatase kev ua si, thiab GGT.

    Kev txhim kho ntawm cov kev mob tshwm sim hauv qab no tau tshaj tawm thaum siv qee yam statins: kev kho mob erectile kawg, raug mob sib txawv ntawm cov mob ntsws interstitial (tshwj xeeb nrog kev siv lub sijhawm ntev), hom 2 mob ntshav qab zib mellitus, qhov ntau zaus ntawm kev txhim kho uas yog nyob ntawm qhov muaj lossis tsis muaj kev pheej hmoo (ua rau cov ntshav txhaws ntshav siab 5.6- 6.9 mmol / l, BMI> 30 kg / m 2, hypertriglyceridemia, keeb kwm ntawm txoj hlab ntshav siab).

    Cov Yuav Tsum Muaj

    Rau cov ntsiav tshuaj ntawm 10 thiab 20 mg

    - Cov tshuaj tiv thaiv tsis haum rau cov tshuaj,

    - mob siab tus kab mob nyob hauv theem nquag lossis hloov pauv ntawm kev ua haujlwm ntawm hepatic transaminases hauv ntshav dej (ntau dua 3 zaug piv nrog VGN) ntawm cov keeb kwm tsis paub,

    - mob rau daim siab ua haujlwm (qhov mob hnyav ntawm 7 txog 9 txog ntawm tus me nyuam-Pugh nplai),

    - nce nyob rau hauv cov concentration ntawm CPK nyob rau hauv cov ntshav los ntawm ntau dua 5 zaug piv nrog VGN,

    - Kev mob raum tsis zoo (CC tsawg dua 30 ml / min),

    - cov neeg mob predisposed rau kev txhim kho ntawm myotoxic muaj teeb meem,

    - tib lub sijhawm tswj hwm ntawm cyclosporine,

    - ua ke siv nrog HIV protease inhibitors,

    - cov kab mob muaj keeb, xws li lactose intolerance, lactase deficiency lossis glucose-galactose malabsorption (vim tias muaj lactose hauv cov tshuaj muaj pes tsawg leeg),

    - cov poj niam uas muaj hnub nyoog yug me nyuam uas tsis siv txoj hauv kev los tiv thaiv kom tsis muaj menyuam,

    - lactation (pub niam mis),

    - lub hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim tsa),

    Txog 40 mg ntsiav tshuaj (ntxiv rau contraindications rau 10 thiab 20 mg ntsiav tshuaj)

    Lub xub ntiag ntawm cov kev pheej hmoo hauv qab no rau kev txhim kho myopathy / rhabdomyolysis:

    - myotoxicity tiv thaiv keeb kwm yav dhau los ntawm kev siv lwm yam tshuaj tiv thaiv ntawm HMG-CoA reductase lossis fibrates hauv keeb kwm,

    - lub raum tsis ua hauj lwm ntawm mob hnyav hnyav (CC 30-60 ml / min),

    - haus cawv ntau dhau,

    - cov xwm txheej uas tuaj yeem ua rau nce ntshav plasma concentration ntawm rosuvastatin,

    - tib lub sij hawm txais tos ntawm fibrates.

    Cov neeg mob ntawm haiv neeg Moob.

    Kev taw qhia ntawm cov leeg mob hauv tsev neeg keeb kwm.

    Rau cov ntsiav tshuaj ntawm 10 thiab 20 mg: muaj keeb kwm txog kab mob siab, mob sepsis, mob ntshav tawm ntshav, kev phais mob ntau ntxiv, kev raug mob, mob hnyav ntawm lub cev, mob endocrine lossis electrolyte kev puas tsuaj, kev tswj tsis tau tus mob, nrog mob me mus rau mob raum tsis ua haujlwm, hypothyroidism, nrog kev siv lwm yam HMG-CoA reductase inhibitors lossis fibrates, cov cim qhia txog keeb kwm ntawm cov leeg mob toxicity, cov kab mob hauv cov leeg mob hauv cov nqaij pob txha, nrog rau kev tswj hwm tib lub sijhawm nrog fibrates, tej yam kev mob uas ua rau muaj kev nce siab ntxiv. thiab rosuvastatin nyob rau hauv cov ntshav ntshav nyob rau hauv cov neeg mob muaj hnub nyoog tshaj 65 xyoo, tus Mongoloid haiv neeg cov neeg mob uas ntev li ntawm cawv noj.

    Txog 40 mg ntsiav tshuaj: nrog cov mob raum tsis ua haujlwm (CC ntau dua 60 ml / min), keeb kwm muaj kab mob siab, mob sepsis, mob ntshav tawm ntshav, kev phais mob ntau ntxiv, kev raug mob, teeb meem loj ntawm lub cev, endocrine lossis hluav taws xob cuam tshuam, tswj tsis tau tus mob, hauv cov neeg mob uas muaj hnub nyoog 65 xyoos.

    Cev xeeb tub thiab lactation

    Rosucard ® yog contraindicated nyob rau hauv cev xeeb tub thiab lactation (pub niam mis).

    Kev siv ntawm Rosucard ® cov poj niam ntawm kev muaj me nyuam hnub nyoogsiv tau yog tias siv tau txoj hauv kev tiv thaiv kom tsis muaj txiaj ntsig thiab yog tias tus neeg mob paub txog kev pheej hmoo txaus los kho tus menyuam.

    Txij li cov roj (cholesterol) thiab cov tshuaj sib tov los ntawm cov roj (cholesterol) yog qhov tseem ceeb rau kev loj hlob ntawm tus me nyuam hauv plab, qhov kev pheej hmoo ntawm kev txwv tsis pub HMG-CoA reductase ntau dhau cov txiaj ntsig ntawm kev siv tshuaj thaum cev xeeb tub. Yog tias kev ntsuas cev xeeb tub thaum kho nrog kev siv tshuaj, Rosucard ® yuav tsum tsis ua mus ntxiv tam sim ntawd, thiab tus neeg mob yuav tsum ceeb toom txog qhov kev pheej hmoo rau tus me nyuam hauv plab.

    Yog tias nws yuav tsum tau siv cov tshuaj thaum lactation, muab cov peev xwm muaj qhov tsis zoo hauv cov menyuam mos, qhov teeb meem ntawm kev txwv tsis pub niam mis rau menyuam yuav tsum raug kho.

    Cov lus qhia tshwj xeeb

    Ua rau lub raum

    Hauv cov neeg mob uas tau txais ntau dua ntawm rosuvastatin (feem ntau 40 mg), tubular proteinuria tau pom, uas feem ntau hloov chaw. Xws li cov proteinuria tsis tau qhia tias muaj cov kab mob hauv lub raum lossis kev loj hlob ntawm lub raum. Hauv cov neeg mob noj cov tshuaj ntawm ib koob ntawm 40 mg, nws raug nquahu kom soj ntsuam lub raum ua haujlwm thaum lub sijhawm kho.

    Qhov cuam tshuam rau cov leeg musculoskeletal

    Thaum siv rosuvastatin hauv txhua qhov koob tshuaj, thiab tshwj xeeb tshaj yog siv ntau dua 20 mg, cov teebmeem hauv qab ntawm cov leeg mus rau hauv cov leeg tau qhia: myalgia, myopathy, muaj qee yam mob, rhabdomyolysis.

    Kev txiav txim siab ntawm CPK cov haujlwm

    Kev txiav txim siab ntawm kev ua haujlwm ntawm CPK yuav tsum tsis txhob ua tomqab kev tawm dag zog lub cev lossis thaum muaj lwm qhov laj thawj uas ua rau muaj kev nce qib ntawm CPK kev ua haujlwm, uas tuaj yeem ua rau kev txhais tsis raug ntawm cov txiaj ntsig. Yog tias qhov pib ua haujlwm ntawm CPK tau nce siab (5 zaug siab dua li VGN), tom qab 5-7 hnub, yuav tsum ntsuas qhov ntsuas zaum ob. Txoj kev kho yuav tsum tsis txhob pib yog tias kev rov ua dua tau lees paub qhov pib ntawm KFK (ntau dua 5 zaug ntau dua VGN).

    Ua ntej pib txoj kev kho

    Thaum siv Rosucard ®, zoo li thaum siv lwm cov HMG-CoA reductase inhibitors, yuav tsum ceev faj rau cov neeg mob uas muaj kev pheej hmoo rau myopathy / rhabdomyolysis. Cov txiaj ntsig pheej hmoo-cov txiaj ntsig yuav tsum raug ntsuas, thiab yog tias tsim nyog, kev soj ntsuam ntawm tus neeg mob yuav tsum tau ua thaum kho.

    Thaum kho

    Qhia rau tus neeg mob txog qhov yuav tsum tau qhia tus kws kho mob tam sim ntawd txog cov kev mob tshwm sim sai sai ntawm cov leeg mob, mob leeg tsis muaj zog lossis mob plab, tshwj xeeb tshaj yog ua ke nrog malaise thiab kub taub hau. Hauv cov neeg mob no, CPK cov haujlwm yuav tsum raug txiav txim. Kev kho yuav tsum tsis ua ntxiv yog tias qhov kev ua ntawm CPK tau nce siab (ntau dua 5 npaug ntawm VGN) lossis yog tias cov tsos mob ntawm ib feem ntawm cov leeg tau tshaj tawm thiab ua rau muaj kev tsis zoo nyob rau txhua hnub (txawm hais tias qhov haujlwm ntawm KFK tsawg dua 5 zaug piv nrog VGN). Yog tias cov tsos mob ploj, thiab CPK cov haujlwm rov qab mus rau qhov qub, kev txiav txim siab yuav tsum tau muab rau rov sau ntawv Rosucard ® lossis lwm qhov HMG-CoA reductase cov tshuaj tiv thaiv nyob rau hauv qis dua nrog kev saib xyuas tus neeg mob.

    Kev soj ntsuam txhua lub sijhawm ntawm CPK cov haujlwm thaum tsis muaj cov tsos mob tsis tuaj yeem ua. Feem ntau tsis tshua muaj kev tiv thaiv kab mob hauv lub cev tiv thaiv kab mob myopathy nrog cov kev soj ntsuam mob hauv cov qauv ntawm kev ua kom tsis muaj zog ntawm cov leeg nqaij thiab qhov nce ntawm kev ua haujlwm ntawm CPK hauv cov ntshav cov ntshav thaum kho lossis thaum noj statins, suav nrog rosuvastatin, tau sau tseg. Cov kev kawm ntxiv ntawm cov leeg thiab cov leeg hlwb, kev tshawb fawb serological, nrog rau kev kho tshuaj tiv thaiv kab mob kuj yuav tsum tau ua. Tsis muaj cov cim ntawm kev cuam tshuam ntau ntxiv ntawm cov leeg pob txha thaum noj rosuvastatin thiab concomitant txoj kev kho. Txawm li cas los xij, kev nce ntxiv ntawm qhov tshwm sim ntawm myositis thiab myopathy tau tshaj tawm nyob rau hauv cov neeg mob noj lwm yam HMG-CoA reductase inhibitors hauv kev sib xyaw nrog fibric acid derivatives, suav nrog gemfibrozil, cyclosporine, nicotinic acid hauv hypolipidemic doses (ntau dua 1 g / hnub), azole antifungal agents, inhibitors HIV tiv thaiv kab mob thiab tshuaj tua kab mob macrolide. Gemfibrozil tsub kom muaj kev pheej hmoo ntawm myopathy thaum siv ua ke nrog qee yam HMG-CoA reductase inhibitors. Yog li, kev siv ib txhij cov tshuaj Rosucard ® thiab gemfibrozil tsis pom zoo. Qhov sib piv ntawm cov kev pheej hmoo thiab cov txiaj ntsig yuav tsum tau ua tib zoo ntsuas thaum rosucard ® yog siv ua ke nrog fibrates lossis hypolipidemic koob ntawm nicotinic acid. Kev siv cov tshuaj Rosucard ® hauv ib koob ntawm 40 mg ua ke nrog fibrates yog contraindicated. 2-4 lub lis piam tom qab pib kev kho mob thiab / lossis nrog kev nce ntxiv ntawm koob tshuaj Rosucard ®, kev saib xyuas cov lipid metabolism yog qhov tsim nyog (kev hloov tshuaj yog tsim nyog yog tias tsim nyog).

    Nws raug nquahu kom txiav txim siab lub siab ua haujlwm kev ntsuas ua ntej pib kev kho thiab 3 lub hlis tom qab pib kho. Kev siv cov tshuaj Rosucard ® yuav tsum tsis ua ntxiv lossis cov koob tshuaj yuav tsum tau txo yog tias qhov kev ua haujlwm ntawm hepatic transaminases hauv cov ntshav ntshav yog 3 zaug siab dua VGN.

    Hauv cov neeg mob hypercholesterolemia vim yog hypothyroidism lossis nephrotic syndrome, kev kho mob ntawm cov kabmob tseem ceeb yuav tsum tau nqa tawm ua ntej kev kho mob nrog Rosucard ®.

    HIV tiv thaiv kabmob

    Kev siv ua ke ntawm cov tshuaj Rosucard ® nrog cov kab mob HIV protease inhibitors tsis pom zoo.

    Cov mob ntsws interstitial

    Thaum siv qee yam statins, tshwj xeeb tshaj yog siv sijhawm ntev, qhia tawm cov xwm txheej ntawm tus mob ntsws interstitial. Kev tshwm sim ntawm tus kab mob tuaj yeem suav nrog ua pa siav, tsis hnoos tsis meej, thiab kev noj qab nyob zoo (tsis muaj zog, poob phaus, thiab kub cev). Yog tias koj xav tias muaj kab mob ntsws interstitial, nws yog qhov yuav tsum tau nres kev kho mob nrog Rosucard ®.

    Mob ntshav qab zib Hom 2

    Cov tshuaj Statin tuaj yeem ua rau nce ntxiv hauv cov ntshav qabzib. Hauv qee tus neeg mob uas muaj qhov pheej hmoo loj ntawm kev mob ntshav qab zib mellitus, cov kev hloov pauv no tuaj yeem ua rau nws qhov kev tshwm sim, uas yog qhov qhia tau rau kev teem sijhawm kho ntshav qab zib. Txawm li cas los xij, ib qho kev txo qis hauv kev pheej hmoo ntawm cov mob vascular nrog statins ua rau muaj kev pheej hmoo ntawm kev tsim muaj ntshav qab zib mellitus, yog li, qhov cuam tshuam no yuav tsum tsis yog lub hauv paus rau kev tshem tawm kev kho mob statin. Cov neeg mob uas muaj kev pheej hmoo (yoo ntshav qabzib siab ntawm 5.6-6.9 mmol / L, BMI> 30 kg / m 2, keeb kwm ntawm hypertriglyceridemia, keeb kwm ntawm lub plawv tawm ntshav) yuav tsum tau saib xyuas thiab cov ntsuas biochemical tsis tu ncua.

    Rosucard ® yuav tsum tsis txhob siv rau hauv cov neeg mob lactase deficiency, galactose intolerance thiab glucose-galactose malabsorption.

    Hauv chav kawm ntawm cov kev tshawb fawb pharmacokinetic ntawm cov neeg mob Suav thiab Nyij Pooj, qhov nce ntawm cov kab ke ntawm rosuvastatin tau muab piv nrog cov ntsuas uas tau txais ntawm cov neeg mob ntawm haiv neeg Caucasian.

    Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

    Ceev faj yuav tsum tau siv thaum tsav cov tsheb thiab cov haujlwm uas xav tau kev ntseeg ntau ntxiv thiab ceev ntawm lub cev kev xav (lub cev tsaus muag yuav tshwm sim thaum kho).

    Noj ntau dhau

    Nrog rau kev tswj fwm ntawm ob peb koob tshuaj txhua txhua hnub, cov chaw muag tshuaj ntawm rosuvastatin tsis hloov pauv.

    Kev Kho Mob: tsis muaj kev kho mob tshwj xeeb, kev kho mob txoj kev kho mob yog nqa tawm los tswj cov haujlwm ntawm cov tseem ceeb hauv nruab nrog cev thiab cov kab ke. Nws yog ib qho tsim nyog yuav tau soj ntsuam cov ntsuas ntawm lub siab ua haujlwm thiab kev ua haujlwm ntawm CPK. Hemodialysis tsis muaj txiaj ntsig.

    Yeeb tshuaj sib cuam tshuam

    Cov nyhuv ntawm lwm cov tshuaj ntawm rosuvastatin

    Cov neeg tiv thaiv ntawm thauj cov protein: rosuvastatin khi rau qee cov thauj cov protein, tshwj xeeb OATP1B1 thiab BCRP.Kev siv cov tshuaj tsis haum xeeb uas thauj cov tshuaj tiv thaiv protein tuaj yeem nrog kev nce siab hauv rosuvastatin hauv cov ntshav ntshav thiab muaj kev pheej hmoo ntawm myopathy (saib cov lus 3).

    Cyclosporin: nrog kev siv rosuvastatin thiab cyclosporine tib lub sijhawm, AUC ntawm rosuvastatin tau nruab nrab 7 lub sijhawm siab dua li uas pom hauv cov neeg tuaj yeem noj qab haus huv. Tsis cuam tshuam rau lub plasma concentration ntawm cyclosporine. Rosuvastatin yog contraindicated rau cov neeg mob noj cyclosporine.

    HIV tiv thaiv kab mob: txawm hais tias qhov tseem ceeb ntawm kev sib txuam tsis paub txog, kev siv cov tshuaj tiv thaiv kab mob HIV tiv thaiv ua rau tuaj yeem ua rau muaj qhov nce ntawm rosuvastatin (saib cov lus 3). Kev kawm pharmacokinetic ntawm kev siv rosuvastatin tib lub sijhawm ntawm 20 mg thiab kev sib koom ua ke npaj muaj ob tus kab mob HIV tiv thaiv inhibitors (400 mg ntawm lopinavir / 100 mg ntawm ritonavir) hauv cov neeg tuaj yeem noj qab haus huv ua rau muaj kwv yees li ob npaug ntawm tsib zaug thiab nce tsib hauv AUC (0-24) thiab Cmax rosuvastatin, ntsig txog. Yog li ntawd, kev siv tshuaj ib txhij Rosucard ® thiab HIV protease inhibitors tsis pom zoo (saib cov lus 3).

    Gemfibrozil thiab lwm yam tshuaj lipid: kev siv sib xyaw ua ke ntawm rosuvastatin thiab gemfibrozil ua rau kev nce qib 2 hauv Cmax thiab AUC ntawm rosuvastatin. Raws li cov ntaub ntawv hais txog kev sib cuam tshuam tshwj xeeb, pharmacokinetically txoj kev sib cuam tshuam tseem ceeb nrog fenofibrate tsis xav tau, kev sib tham ntawm pharmacodynamic tau. Gemfibrozil, fenofibrate, lwm cov fibrates, thiab nicotinic acid nyob rau hauv lipid txo cov tshuaj (ntau dua 1 g / hnub) nce qhov kev pheej hmoo ntawm myopathy thaum siv nrog HMG-CoA reductase inhibitors, tej zaum vim qhov tseeb tias lawv tuaj yeem ua rau mob myopathy thaum siv hauv raws li monotherapy. Thaum noj cov tshuaj nrog gemfibrozil, fibrates, nicotinic acid nyob rau hauv lipid txo qis koob tshuaj, cov neeg mob raug pom zoo ua ntej pib ntawm Rosucard mg 5 mg, koob tshuaj 40 mg yog contraindicated nyob rau hauv nrog fibrates.

    Fusidic acid: tsis muaj cov kev tshawb fawb tshwj xeeb tau ua rau kev sib cuam tshuam yeeb tshuaj ntawm fusidic acid thiab rosuvastatin, tab sis muaj cov ntaub ntawv cais ntawm cov neeg mob rhabdomyolysis.

    Ezetimibe: kev siv tshuaj ib txhij Rosucard ® ntawm ib koob ntawm 10 mg thiab ezetimibe ntawm koob tshuaj 10 mg tau nrog los ntawm kev nce ntxiv ntawm AUC ntawm rosuvastatin hauv cov neeg mob hypercholesterolemia (saib cov lus 3). Nws yog tsis yooj yim sua kom cais tawm kev pheej hmoo ntawm kev phiv los ntawm kev sib raug zoo ntawm cov tshuaj sib tov ntawm cov tshuaj Rosucard ® thiab ezetimibe.

    Erythromycin: concomitant siv rosuvastatin thiab erythromycin ua rau txo qis hauv AUC(0-t) 20% rosuvastatin thiab Cmax rosuvastatin 30%. Xws li kev cuam tshuam tuaj yeem tshwm sim los ntawm kev mob plab hnyuv ntxiv los ntawm kev noj erythromycin.

    Antacids: kev siv tib lub sijhawm rosuvastatin thiab kev ncua ntawm cov tshuaj antacids uas muaj aluminium lossis magnesium hydroxide, ua rau txo qis ntawm lub plasma concentration ntawm rosuvastatin los ntawm kwv yees li 50%. Cov nyhuv no tsis tshua pom zoo yog tias antacids siv 2 teev tom qab noj rosuvastatin. Cov kab mob tseem ceeb ntawm qhov kev sib txuam no tsis tau kawm.

    Isoenzymes ntawm cytochrome P450 system: Hauv vivo thiab hauv kev tshawb fawb hauv vitro tau qhia tias rosuvastatin tsis yog ib qho tsis haum lossis tsis ua rau muaj cytochrome P450 isoenzymes. Tsis tas li ntawd, rosuvastatin yog lub zog tsis muaj zog rau cov enzymes no. Yog li no, kev sib cuam tshuam ntawm rosuvastatin nrog lwm cov tshuaj ntawm theem metabolic koom nrog cytochrome P450 isoenzymes tsis xav. Tsis muaj kev cuam tshuam los ntawm kev kho mob tseem ceeb ntawm rosuvastatin thiab fluconazole (ib qho inhibitor ntawm isoenzymes CYP2C9 thiab CYP3A4) thiab ketoconazole (ib qho inhibitor ntawm isoenzymes CYP2A6 thiab CYP3A4).

    Kev cuam tshuam nrog cov tshuaj uas yuav tsum tau txhaj tshuaj ntawm rosuvastatin (saib cov lus 3)

    Cov koob tshuaj ntawm rosuvastatin yuav tsum tau hloov kho yog tsim nyog, nws cov kev sib xyaw nrog cov tshuaj uas ua rau muaj kev nce siab ntxiv ntawm rosuvastatin. Yog tias qhov nce ntxiv ntawm 2 zaug lossis ntau dua qhov xav tau, thawj zaug kev siv tshuaj ntawm Rosucard ® yuav tsum yog 5 mg 1 zaug / hnub. Koj kuj yuav tsum kho qhov siab tshaj plaws txhua hnub ntawm Rosucard ® kom qhov xav tias yuav kis tau ntawm rosuvastatin tsis pub tshaj qhov ntawd rau ib koob ntawm 40 mg noj tsis tas yuav muaj kev tswj hwm ib txwm siv tshuaj uas cuam tshuam nrog rosuvastatin. Piv txwv li, qhov siab tshaj plaws txhua hnub ntawm rosuvastatin nrog kev siv ib txhij nrog gemfibrozil yog 20 mg (nce ntxiv ntawm 1,9 zaug), nrog ritonavir / atazanavir - 10 mg (nce ntxiv yog 3.1 zaug).

    Cov lus 3. Cov txiaj ntsig ntawm concomitant kev kho mob ntawm kev kis tus kabmob rosuvastatin (AUC, cov ntaub ntawv tau qhia nyob rau hauv qis qis kev txiav txim siab) - cov txiaj ntsig ntawm kev soj ntsuam tshawb pom



















































































































    Kev qhia ntau yam kev sib txuas lus Rosuvastatin regimen AUC hloov hauv rosuvastatin
    Cyclosporin 75-200 mg 2 zaug / hnub, 6 hli 10 mg 1 zaug / hnub, 10 hnub 7.1x magnification
    Atazanavir 300 mg / ritonavir 100 mg 1 lub sijhawm / hnub, 8 hnub 10 mg ib koob tshuaj 3.1x nce
    Simeprevir 150 mg 1 lub sijhawm / hnub, 7 hnub 10 mg ib koob tshuaj 2.8x magnification
    Lopinavir 400 mg / ritonavir 100 mg 2 zaug / hnub, 17 hnub 20 mg 1 lub sijhawm / hnub, 7 hnub 2.1x nce
    Clopidogrel 300 mg (chaw thau khoom), tom qab ntawd 75 mg tom qab 24 teev 20 mg ib koob tshuaj 2x nce
    Gemfibrozil 600 mg 2 zaug / hnub, 7 hnub 80 mg ib koob tshuaj 1.9x magnification
    Eltrombopag 75 mg 1 lub sijhawm / hnub, 10 hnub 10 mg ib koob tshuaj 1.6x magnification
    Darunavir 600 mg / ritonavir 100 mg 2 zaug / hnub, 7 hnub 10 mg 1 zaug / hnub, 7 hnub 1.5x magnification
    Tipranavir 500 mg / ritonavir 200 mg 2 zaug / hnub, 11 hnub 10 mg ib koob tshuaj 1,4 npaug nce ntxiv
    Dronedarone 400 mg 2 zaug / hnub Tsis muaj ntaub ntawv 1,4 npaug nce ntxiv
    Itraconazole 200 mg 1 lub sijhawm / hnub, 5 hnub 10 mg lossis 80 mg ib zaug 1,4 npaug nce ntxiv
    Ezetimibe 10 mg 1 lub sijhawm / hnub, 14 hnub 10 mg 1 zaug / hnub, 14 hnub 1.2x magnification
    Fosamprenavir 700 mg / ritonavir 100 mg 2 zaug / hnub, 8 hnub 10 mg ib koob tshuaj Tsis hloov pauv
    Aleglitazar 0.3 mg, 7 hnub 40 mg, 7 hnub Tsis hloov pauv
    Silymarin 140 mg 3 zaug / hnub, 5 hnub 10 mg ib koob tshuaj Tsis muaj hloov
    Fenofibrate 67 mg 3 zaug / hnub, 7 hnub 10 mg, 7 hnub Tsis muaj hloov
    Rifampin 450 mg 1 zaug / hnub, 7 hnub 20 mg ib koob tshuaj Tsis hloov pauv
    Ketoconazole 200 mg 2 zaug / hnub, 7 hnub 80 mg ib koob tshuaj Tsis muaj hloov
    Fluconazole 200 mg 1 zaug / hnub, 11 hnub 80 mg ib koob tshuaj Tsis muaj hloov
    Erythromycin 500 mg 4 zaug / hnub, 7 hnub 80 mg ib koob tshuaj 28% txo
    Baikalin 50 mg 3 zaug / hnub, 14 hnub 20 mg ib koob tshuaj 47% txo

    Cov nyhuv ntawm rosuvastatin ntawm lwm cov tshuaj

    Antioxidists Vitamin K: pib rosuvastatin txoj kev kho lossis nce qhov koob tshuaj rosuvastatin hauv cov neeg mob uas tau txais cov tshuaj tiv thaiv vitamin K tib lub sijhawm tib lub sijhawm (piv txwv, warfarin lossis lwm yam tshuaj coumarin anticoagulants) tuaj yeem ua rau muaj kev nce hauv INR. Kev tshem tawm lossis txo qhov hno ntawm Rosucard ® yuav ua rau INR poob qis. Hauv cov xwm txheej zoo li no, kev tswj hwm INR tau pom zoo.

    Kev kho qhov ncauj / tshuaj kho hloov:kev siv tib lub sijhawm rosuvastatin thiab tshuaj noj hauv qhov ncauj ua rau kom nce qhov AUC ntawm ethinyl estradiol thiab AUC ntawm norgestrel los ntawm 26% thiab 34%, feem. Xws li nce hauv plasma concentration yuav tsum tau coj mus rau hauv tus account thaum xaiv cov koob tshuaj tiv thaiv kab mob hauv qhov ncauj.

    Tsis muaj ntaub ntawv pharmacokinetic qhia txog kev siv rosuvastatin thiab kev hloov kho tshuaj hormones thaum tib lub sijhawm. Ib qho zoo sib xws tsis tuaj yeem raug tshem tawm nrog kev siv rosuvastatin thiab kev hloov kho tshuaj hormones thaum tib lub sijhawm. Txawm li cas los xij, qhov kev sib txuam no tau siv dav dav thaum sim kho mob thiab tau txais txiaj ntsig zoo los ntawm cov neeg mob.

    Lwm yam tshuaj: tsis muaj kev sib cuam tshuam hauv cov chaw kho mob ntawm rosuvastatin nrog digoxin yog qhov xav tau.

    Pharmacodynamics thiab pharmacokinetics

    Rosucard nyob muaj pawg statinsCov. Nws inhibits HMG-CoA reductase - ib qho enzyme uas hloov siab los ntseeg GMG-CoA hauv mevalonate.

    Txuas ntxiv, qhov cuab yeej no ua kom nce tus naj npawb ntawm LDL txais neeg rau hepatocytesuas ua rau kev siv zog ntawm catabolism thiab ntes LDL thiab ua rau synthesis inhibition VLDLtxo cov ntsiab lus txhua yam VLDL thiab LDLCov. Cov tshuaj txo cov concentration HS-LDL, high density tsis-lipoprotein roj, HS-VLDLP, TG, apolipoprotein B, TG-VLDLP, tag nrho xc, thiab tseem nce cov ntsiab lus ApoA-1 thiab HS-HDLCov. Ntxiv rau, nws txo qhov feem cuam ApoVthiab ApoA-1, HS-tsis-HDL thiab HS-HDL, HS-LDL thiab HS-HDL, tag nrho xc thiab HS-HDL.

    Cov nyhuv tseem ceeb ntawm Rosucard yog ncaj qha sib luag nrog cov tshuaj muab tshuaj. Kev kho mob nyhuv tom qab pib kho mob yog pom tau tom qab ib lub limtiam, tom qab li ib hlis nws dhau los ua qhov siab tshaj plaws, thiab tom qab ntawd nws ntxiv dag zog thiab ua mus tas li.

    Qhov siab tshaj plaws ntawm cov khoom tseem ceeb hauv plasma tsim muaj tom qab 5 teev. Tsis Yog kev noj qab nyob zoo ua tau nce 20%. Qhov degree ntawm kev txuas nrog cov ntshav ntshav protein yog li 90%.

    Nrog kev siv tsis tu ncua, cov chaw muag tshuaj tsis hloov.

    Metabolized Rosucard los ntawm lub siab. Penetrates zoo placental teeb meemCov. Lub ntsiab metabolites – N-dismethyl thiab lactone metabolites.

    Ib nrab-lub neej yog kwv yees li 19 teev, thaum nws tsis hloov pauv yog tias qhov ntau ntawm cov tshuaj. Ntshav tshem tawm ntawm nruab nrab - 50 l / h. Kwv yees li 90% ntawm cov tshuaj nquag raug tso tawm los ntawm txoj hnyuv tsis hloov, qhov seem dhau los ntawm lub raum.

    Kev sib deev thiab hnub nyoog tsis cuam tshuam rau lub khw muag tshuaj ntawm Rosucard. Txawm li cas los xij, nws nyob ntawm haiv neeg. Isdias neeg muaj ntau lub siab xav thiab nruab nrab Auc 1.3 npaug ntau dua qhov ntawd ntawm haiv neeg Caucasian. Aucnyob hauv cov neeg ntawm haiv neeg Moob tshaj lij, 2 npaug ntau dua.

    Kev ntsuas rau siv Rosucard

    Kev ntsuas rau kev siv Rosucard yog raws li hauv qab no:

    • thawj hypercholesterolemia lossis sib xyaw dyslipidemia - cov tshuaj siv los ntxiv rau hauv kev noj haus yog tias kev noj zaub mov zoo ib leeg tsis txaus,
    • qhov xav tau rau kev loj hlob qeeb atherosclerosis - cov tshuaj siv yog txhawm rau ntxiv rau hauv kev noj zaub mov noj raws li ib feem ntawm kev kho mob kom txo qis tag nrho cov roj (cholesterol) thiab Cov roj khov ua tiav rau cov nqi ib txwm
    • tsev neeg homozygous hypercholesterolemia - cov tshuaj siv los siv ntxiv rau kev noj haus lossis ua khoom siv lipid tej kev kho
    • qhov xav tau ntawm kev tiv thaiv ntawm cov teeb meem hauv kev ua haujlwm ntawm cov hlab plawv nrog qhov kev pheej hmoo ntawm kev tshwm simatherosclerotic cov kab mob plawv - cov tshuaj siv yog ib feem ntawm txoj kev kho.

    Sab sij huam

    Kev phiv tshuaj los ntawm kev siv cov tshuaj yuav yog raws li hauv qab no:

    • cov leeg hlwb: mob taub hau, asthenic mob ntsws, kiv taub hau,
    • kev ua pa: hnoos, dyspnea,
    • musculoskeletal system: myalgia,
    • daim tawv nqaij thiab nqaij tawv nqaij subcutaneous: peripheral edema, Stevens-Johnson mob,
    • kev ntsuas ntsuas: hloov zuj zus hauv kev ua ntshiab CPK nyob ntawm ntau npaum li cas
    • ua xua: khaus, urticariaua pob
    • plab zom mov: xeev siab, mob hauv plab, cem quavntuav zawv plab,
    • endocrine system: ntshav qab zib hom II,
    • system urinary: proteinuriamob txeeb zig.

    Nyob rau hauv tsawg zaus, ua tau peripheral neuropathy, pancreatitisnco qab tsis zookab mob siab, dajntoo, mob hlwb, rhabdomyolysis, angioedema, hematuria, nraum nce AST kev ua si thiab ALT.

    Kev sib txuam

    Cyclosporin txuam nrog rosucard nce nws cov nqi Auc txog 7 zaus. Noj ntau dua 5 mg yog tsis pom zoo.

    Gemfibrozilthiab lwm tus lipid-txos tshuaj siv nrog rosucard ua rau muaj kev nce hauv nws qhov siab tshaj plaws thiab Auc txog ob zaug. Txoj kev pheej hmoo ntawm myopathiesCov. Qhov siab tshaj plaws thaum sib xyaw nrog Gemfibrozil - 20 mg. Thaum tham nrog fibrates qhov ntau ntawm cov tshuaj hauv 40 mg tsis raug tso cai, thawj koob tshuaj yog 5 mg.

    Yeeb tshuaj cuam tshuam nrog protease inhibitors tej zaum yuav loj tuaj raug Rosuvastatin. Kev siv ntawm kev sib xyaw no tsis pom zoo HIV kis rau cov neeg mob.

    Sib txuam ua ke Erythromycin thiab rosucard txo Auctom kawg los ntawm 20%, thiab qhov siab tshaj plaws - los ntawm 30%.

    Thaum muab cov tshuaj no nrog Lopinavir thiab ritonavir nce nws qhov sib npaug Auc thiab qhov siab tshaj plaws.

    Vitamin K Antagonists thaum sib tham nrog rosucard ua rau muaj kev nce ntxiv normalized thoob ntiaj teb kev sib raug zoo.

    Ezetimibe ib txhij nrog rosuvastatin yuav ua rau muaj kev phiv tshuaj.

    Antacid tshuaj nrog aluminium hydroxide lossis magnesium txo cov tshuaj hauv lub cev kwv yees li ib nrab. Yog li nyob nruab nrab ntawm lawv kev txais tos koj yuav tsum mus so li 2 teev.

    Thaum muab Rosucard nrog qhov ncauj tiv thaiv txhais tau tias saib xyuas cov neeg mob.

    Kev txheeb xyuas txog Rosucard

    Kev txheeb xyuas txog Rosucard feem ntau zoo. Cov cuab yeej no feem ntau qhia los ntawm cov kws kho mob. Nws yog tus nqi pheej yig heev, yog li yuav nws ncaj nraim. Cov neeg uas twb tau txais kev kho mob nrog cov tshuaj no tawm los xyuas txog Rosucard, nyob rau hauv uas nws tau tshaj tawm tias cov tshuaj tau pab lawv tswj cov roj (cholesterol) zoo li qub thiab nres cov kev muaj mob.

    Rosucard Nqe

    Tus nqi ntawm Rosucard yog suav tias yog tus nqi pheej yig piv rau ntau yam analogues. Tus nqi pes tsawg ntawm cov tshuaj nyob ntawm cov ntsiab lus ntawm cov tshuaj nquag hauv cov ntsiav tshuaj. Yog li, tus nqi ntawm 10 mg rosucard hauv ib pob nrog 3 daim hlau yog txog 500 rubles hauv tebchaws Russia lossis 100 hryvnias hauv Ukraine. Thiab tus nqi ntawm Rosucard 20 mg nyob rau hauv ib pob nrog 3 daim hlau yog li 640 rubles hauv tebchaws Russia lossis 150 hryvnias hauv Ukraine.

    Cov chaw muag tshuaj

    Lub ntsiab lus nquag nyob hauv kev npaj Rosucard, rosuvastatin, muaj cov yam ntxwv rau inhibit reductase kev ua si, thiab txo cov synthesis ntawm mevalonate lwg me me, uas yog lub luag haujlwm rau cov synthesis ntawm cov roj (cholesterol) hauv cov thawj kauj ruam hauv kev mob hlwb.

    Cov tshuaj no muaj qhov qhia tau zoo tshaj plaws ntawm lipoproteins, txo lawv cov synthesis los ntawm daim siab ua haujlwm, uas txo qis cov lipoproteins molecular hnyav hauv cov ntshav thiab nce qhov siab ntawm lipoproteins molecular ceev.

    Pharmacokinetics ntawm cov tshuaj Rosucard:

    • Qhov siab tshaj plaws ntawm kev ua kom nquag plias hauv cov ntshav plasma muaj pes tsawg leeg, tom qab noj cov ntsiav tshuaj, tshwm sim tom qab 5 teev,
    • Lub bioavailability ntawm cov tshuaj yog 20.0%,
    • Rosucard raug rau hauv qhov system nyob ntawm kev ua kom ntau ntxiv,
    • 90.0% ntawm cov tshuaj Rosucard khi rau cov ntshav plasma protein, feem ntau, nws yog proteinin,
    • Cov roj metabolism hauv cov tshuaj hauv lub siab ua rau theem pib yog li 10.0%,
    • Rau cytochrome isoenzyme No. P450, cov tshuaj ua kom nquag plias rosuvastatin yog cov khoom siv tshuaj,
    • Cov tshuaj tawm los ntawm 90.0% nrog quav, thiab lub plab hnyuv muaj lub luag haujlwm rau nws,
    • 10.0 yog tawm siv lub raum hlwb nrog zis,
    • Cov tshuaj pharmacokinetics ntawm cov tshuaj Rosucard tsis yog nyob ntawm seb muaj hnub nyoog li cas ntawm cov neeg mob, nrog rau cov tub los ntxhais. Cov tshuaj ua haujlwm sib npaug, ob qho tib si hauv lub cev ntawm tus neeg hluas thiab cov neeg laus, tsuas yog nyob rau lub hnub nyoog laus yuav tsum tsuas yog cov koob tshuaj tsawg kawg nkaus rau kev kho mob ntawm cov roj cholesterol siab hauv cov ntshav.

    Kev pib kho qhov mob ntawm cov tshuaj ntawm Rosacard pawg statins tuaj yeem hnov ​​tom qab noj cov tshuaj rau 7 hnub. Qhov siab tshaj plaws ntawm cov chav kawm ntawm kev kho mob tuaj yeem pom tom qab noj cov ntsiav tshuaj rau 14 hnub.

    Tus nqi ntawm cov tshuaj Rosucard nyob ntawm qhov chaw tsim tshuaj, lub teb chaws uas cov tshuaj ua. Cov tshuaj Lavxias analogues ntawm cov tshuaj yog pheej yig dua, tab sis cov nyhuv tshuaj tsis cuam tshuam rau tus nqi ntawm cov tshuaj.

    Cov lus sib piv Lavxias ntawm Rosucard, raws li txo cov txiaj ntsig ntawm cov ntshav hauv cov roj ntshav, ntxiv rau cov tshuaj txawv teb chaws.

    Tus nqi ntawm cov tshuaj Rosucard hauv Lavxias Federation:

    • Tus nqi ntawm rosucard 10.0 mg (30 ntsiav tshuaj) - 550.00 rubles,
    • Cov Tshuaj Noj Rosucard 10.0 mg (90 pcs.) - 1540.00 rubles,
    • Cov tshuaj qub Rosucard 20.0 mg. (30 tab.) - 860.00 rubles.

    Lub txee lub neej thiab siv cov ntsiav tshuaj Rosucard yog ib xyoos txij li hnub lawv tso. Tom qab hnub tas sij hawm, qhov tshuaj zoo dua tsis siv.

    Rosucard cov nqi hauv cov khw muag tshuaj hauv Moscow

    ntsiav tshuaj10 mg30 pcs625 rub.
    10 mg60 pcs.≈ 1070 rub.
    10 mg90 pcs.≈ 1468 rub.
    20 mg30 pcs≈ 918 rub.
    20 mg60 pcs.≈ 1570 rub.
    20 mg90 pcs.≈ 2194.5 rub.
    40 mg30 pcs≈ 1125 rub.
    40 mg90 pcs.≈ 2824 rub.


    Cov kws kho mob tshuaj xyuas txog rosacea

    Ntsuam xyuas 3.3 / 5
    Txij nkawm
    Nqe / zoo
    Sab sij huam

    Ib qho piv txwv zoo ntawm Czech keeb kwm, ua los ntawm cov khoom lag luam zoo raw khoom, pom tau zoo heev hauv chaw kuaj mob.

    Raws li txoj cai, rosuvastatin tsis tuaj yeem lees txais rau tus nqi, thiab cov ntaub ntawv no tsis muaj qhov tshwj xeeb, hmoov tsis.

    Cov tshuaj yeej ua haujlwm, nws yog siv tau tsuas yog tom qab sab laj tus kws tshaj lij.

    Ntsuam xyuas 3.8 / 5
    Txij nkawm
    Nqe / zoo
    Sab sij huam

    Nws txaus siab rau qhov ua tau zoo ntawm cov tshuaj feem ntau - nws normalizes lipid metabolism zoo nrog cov kev mob me thiab cov txheej txheem tsis quav yeeb, ntxiv rau - qhov no yog qhov tseeb tus nqi, piv rau tus ntoo khaub lig.

    Muaj cov kev mob tshwm sim, tab sis nws tsis tshua pom muaj, vim tias kuv sau tshuaj nws ntau zaus nrog kev ua txhaum me me - koob tshuaj tsawg kawg 5-10 mg.

    Ntsuam xyuas 2.5 / 5
    Txij nkawm
    Nqe / zoo
    Sab sij huam

    Raws li rau kev siv tau: statins tsis yog cov tshuaj pheej yig tshaj plaws. Tab sis lawv nyob ntawm cov tshuaj ntawd tsawg leej thiaj cawm tau neeg txoj sia. Ntawm chav kawm, nrog lub caveat - cawm lub neej ntawm cov neeg uas muaj kab mob cuam tshuam nrog atherosclerosis - myocardial infarction, angina pectoris, atherosclerosis ntawm cov hlab ntsha ntawm qis qis. Yog tias ib qho statin raug nqi 100-200 rubles, Kuv ntshai tias nws yuav los kho nws.

    Ntau cov generics (luam tawm cov ntawv luam tawm) ntawm statins, tab sis, tsis yog, tsis yog txhua tus ntawm lawv muaj kev sib txig sib luag. Tus kws kho mob uas muaj lub luag haujlwm yuav sau tseg tsuas yog cov generics uas muaj cov ntaub ntawv zoo los ntawm kev tshawb fawb txog kev kho kom sib luag nrog cov tshuaj qub (hauv peb qhov teeb meem, nws yog tus ntoo khaub lig). Cov kws ua hauj lwm muag tshuaj hauv cov teeb meem no, raws li txoj cai, tsis yog taw qhia txhua qhov thiab nug lawv txog ib qho kev hloov pauv twg, nrog rau kev siv lawv cov lus pom zoo rau “hloov chaw”, yog txoj hauv kev rau kev poob siab hauv kev kho mob.

    Rosucard Xyuas Neeg Mob

    Kuv tsis paub tias nws tsis ua rau muaj kev phiv tshuaj rau koj cov neeg txheeb ze li cas. Kuv tus txiv thiab kuv tam sim ntawd tom qab noj cov tshuaj no pib raws plab, ib me ntsis tom qab, insomnia thiab kev tshwm sim coj txawv txawv nrog lub siab txuas nrog. Yog li no, tam sim no peb yuav txiav txim siab nrog tus kws kho mob txog lub neej yav tom ntej ntawm kev txais nws.

    Kuv yuav Rosucard rau 508 rubles. Kuv haus ib hlis tom qab ib hnub, cov roj cholesterol poob ntawm 7 mus rau 4.6. Kuv tsis haus dej thiab tom qab 2 lub hlis ntxiv 6.8. Kuv tawm tsam ntev, tab sis txiav txim siab: Kuv yuav haus. Kuv tau sim tshuaj ntsuab sib txawv, haus cov atherocliphite, tsis muaj kev cuam tshuam.

    "Tus nqi yuav pheej yig heev" - 900 re (!?) Qhov no pheej yig. Kuv nkag siab tias ntawm no koj pom qee tus neeg nplua nuj nyiaj tau kho.

    Rosucard yog cov tshuaj zoo. Kuv tau xaiv kuv tus kws kho mob rau kuv pog txog kev tiv thaiv. Cov tshuaj yeeb yam pom tshwm sim tom qab kwv yees li 1 lub hlis ntawm kev siv. Hauv peb qhov teeb meem, nws yog ib qho tseem ceeb uas rosucard tuaj yeem nqa nrog lwm cov tshuaj. Nws zoo siab thiab, qhov tseem ceeb tshaj plaws, tsis muaj kev phiv tshuaj. Peb tsis tau pom tias muaj qhov khuam.

    Kuv yawg (72 xyoo) muaj teeb meem plawv tau kaum xyoo, tej zaum. Hauv kev sib txuas nrog qhov tsis zoo, peb tau mus cuag kws kho plawv, uas qhia kom peb pib noj rosacea. Tus nqi yog tus nqi pheej yig, peb tau tau haus nws rau lub hlis thib peb. Los ntawm txoj kev, ntawm kev tswj hwm cov ntshav pub dawb, cov roj cholesterol tsawg dua. Peb zoo siab nrog rosacea!

    Cov lus qhia luv luv

    Rosucard (nquag muaj tshuaj - rosuvastatin) - tshuaj lipid-txo qis tshuaj los ntawm pab pawg ntawm statins. Niaj hnub no, kwv yees li 80-95% ntawm cov neeg mob mob plawv (yog tias peb coj cov teb chaws vam meej) noj statins. Xws li qhov nrov ntawm cov pab pawg no qhia kev ntseeg siab hauv nws los ntawm kev kho plawv, uas yuav tsum tau txiav txim siab tag nrho: nyob rau xyoo tsis ntev los no, cov txiaj ntsig ntawm kev kuaj mob ntau tau nthuav tawm rau lub tsev hais plaub ntawm zej zog kev kho mob, lees paub rau qee yam kev txo qis kev mob plawv thaum lub sijhawm kho mob nrog statins. Tsis tas li ntawd, ntxiv los ntawm cov tshuaj no, uas yog kiag li tus kheej, tau tshwm sim: piv txwv, lawv cov anti-ischemic effect. Thiab cov nyhuv tawm tsam ntawm statins yog li tau hais tias qee tus kws kho mob twb tau sim kho tus mob rheumatoid nrog lawv. Rosucard yog tag nrho cov tshuaj hluavtaws los ntawm pawg statin, pom zoo siv rau thaum 2000s ntawm lub xyoo pua xeem. Txawm hais tias muaj kev sib tw los ntawm tsib lwm yam statins ntawm lub khw muag tshuaj niaj hnub no, rosucard yog ib qho (feem ntau tsis yog) cov tshuaj muaj npe hauv cov pab pawg no raws li kev loj hlob ntawm qhov muaj pes tsawg tus tshuaj kho mob. Tom qab noj ib koob ntawm cov tshuaj, ib lub ncov hauv nws lub plasma concentration tau pom tom qab 5 teev. Rosucard muaj qhov ntev tshaj ib nrab-lub neej ntawm 19 teev. Cov chaw muag tshuaj ntawm cov tshuaj tsis cuam tshuam los ntawm yam tseem ceeb xws li hnub nyoog, tub los ntxhais, kev mob plab hnyuv tag nrho, muaj cov nplooj siab tsis ua haujlwm (tshwj tsis yog nws cov ntawv hnyav). Cov tshuaj molecule ntawm rosuvastatin - cov tshuaj ua haujlwm ntawm cov tshuaj - yog hydrophilic, ua rau nws tsawg dua nws cov txiaj ntsig ntawm kev sib txuas ntawm cov roj cholesterol hauv cov leeg nqaij ntawm cov leeg pob txha. Vim tias qhov no, rosucard tsis tshua hais txog kev phiv los ntawm txais tos hauv lwm yam statins. Lwm qhov zoo dua ntawm cov tshuaj dhau ntawm "npoj yaig" hauv pawg pharmacological (feem ntau tshaj li atorvastatin thiab simvastatin) yog tias nws xyaum tsis hnov ​​mob nrog cov enzymes ntawm cytochrome P450 system, uas tso cai rau rosucard yuav tau muab tso ua ke nrog ntau lwm yam tshuaj (tshuaj tua kab mob, antihistamines, antiulcer tshuaj, antifungal tus neeg sawv cev, thiab lwm yam.

    e.) yam tsis muaj kev pheej hmoo ntawm lawv qhov kev cuam tshuam tsis sib xws. Qhov ua tau zoo ntawm rosuvastatin (rosucard) tau kawm thiab tseem tab tom kawm hauv ntau qhov kev sim tshuaj. Ntawm tus naj npawb ntawm cov kev tshawb fawb tau ua tiav rau hnub tim, MERCURY txoj kev tshawb nrhiav, uas tau qhia qhov txiaj ntsig tseem ceeb ntawm cov tshuaj no dhau lwm cov statins hauv nws cov nyhuv ntawm lipid profile, yog qhov kev nyiam tshaj plaws. Qib theem ntawm cov "tsis zoo" cov roj (LDL) thaum noj cov tshuaj ntxiv muaj tiav rau 86% ntawm cov neeg mob (siv cov tshuaj atorvastatin zoo li cov txiaj ntsig xav tau tsuas yog 80%). Nyob rau tib lub sijhawm, theem ntawm cov roj "zoo" (HDL) yog siab dua li thaum siv cov tshuaj atorvastatin. Txo cov ntsiab lus ntawm atherogenic cholesterol feem ntau (feem ntau LDL) tsis yog lub hom phiaj ntawm kev kho lipid-txo qis. Nws kuj tseem yuav tsum tau tsom txhawm rau nce cov ntsiab lus ntawm antiatherogenic feem ntawm HDL lipoproteins, qib uas, raws li txoj cai, txo. Thiab rosucard ntse kov yeej qhov no: hauv nws cov nyhuv ntawm kev txuam ntawm lipoproteins, nws tseem dhau simvastatin thiab pravastatin. Txog rau hnub tim, cov tshuaj raug pom zoo kom noj nyob rau hauv ib koob tshuaj 10-40 mg ib hnub twg.

    Kev nyab xeeb ntawm kev kho yog tsis muaj qhov tseem ceeb tshaj plaws ntawm nws dua li kev nyab xeeb, tshwj xeeb tshaj yog tias cov tshuaj yog npaj rau cov neeg mob ntau. Ua tib zoo saib xyuas cov teeb meem kev nyab xeeb hauv statin tau muab los ntawm qhov xwm txheej nrog cerivastatin, uas tau thim tawm ntawm lub khw vim muaj cov teeb meem ntau. Hauv qhov no, rosuvastatin (rosucard) tau dhau los ua kev tshawb fawb nruj hauv qhov tseeb ntawm nws qhov kev nyab xeeb. Thiab, raws li tau lees paub thaum lub sijhawm sim tshuaj, qhov kev pheej hmoo ntawm kev phiv thaum noj cov tshuaj (raug rau cov koob tshuaj pom zoo) tsis muaj siab dua li qhov seem ntawm cov kev siv tam sim no.

    Kws Tshuaj

    Hypolipidemic tshuaj los ntawm pab pawg neeg ntawm statins. Xaiv kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov HMG-CoA rau mevalonate, ib qho ua ntej ntawm cov roj (Ch).

    Nce tus naj npawb ntawm LDL receptors nyob rau saum npoo ntawm hepatocytes, uas ua rau kom muaj kev nce siab thiab catabolism ntawm LDL, inhibition of VLDL synthesis, txo tag nrho cov ntsiab lus ntawm LDL thiab VLDL. Txo qhov kev tso cia ntawm LDL-C, HDL roj-cholesterol tsis-lipoproteins (HDL-tsis-HDL), HDL-V, tag nrho cov roj cholesterol, TG, TG-VLDL, apolipoprotein B (ApoV), txo qhov feem ntawm LDL-C / LDL-C, tag nrho - HDL, Chs-tsis HDL / Chs-HDL, ApoV / apolipoprotein A-1 (ApoA-1), nce qhov nce ntawm Chs-HDL thiab ApoA-1.

    Kev lipid-txo cov nyhuv yog ncaj qha ncaj qha rau cov koob tshuaj uas tau xaj tshuaj. Kev kho mob tshwm sim nyob rau hauv 1 lub lis piam tom qab pib kho, tom qab 2 lub lis piam nce mus txog 90% ntawm qhov siab tshaj plaws, nce mus txog qhov siab kawg los ntawm 4 lub lis piam thiab tom qab ntawd mus tas li. Cov tshuaj no zoo rau cov neeg laus uas muaj hypercholesterolemia nrog lossis tsis muaj hypertriglyceridemia (tsis hais haiv neeg, poj niam lossis txiv neej), suav nrog hauv cov neeg mob ntshav qab zib mellitus thiab tsev neeg hypercholesterolemia. Hauv 80% ntawm cov neeg mob uas muaj hom IIa thiab IIb hypercholesterolemia (Fredrickson kev faib tawm) nrog qhov pib nruab nrab ntawm LDL-C txog li 4.8 mmol / L, thaum noj cov tshuaj ntawm 10 mg, qhov siab ntawm LDL-C nce mus txog tsawg dua 3 mmol / L. Hauv cov neeg mob uas muaj homozygous tsev neeg hypercholesterolemia tau txais cov tshuaj ntawm ib koob tshuaj 20 mg thiab 40 mg, qhov nruab nrab txo qis hauv kev saib xyuas ntawm LDL-C yog 22%.

    Ib qho kev tiv thaiv ntxiv tau pom nyob rau hauv kev sib xyaw nrog fenofibrate (hauv kev sib piv rau qhov kev txo qis ntawm cov concentration ntawm TG thiab nrog nicotinic acid hauv lipid-txo cov koob tshuaj (tsis pub tsawg dua 1 g / hnub) (hauv qhov sib piv rau qhov kev txo qis hauv kev mloog ntawm HDL-C).

    Yuav ua li cas noj rosucard?

    Cov tshuaj Rosucard yuav tsum tau noj qhov ncauj nrog qhov dej txaus. Kev ntxo me me hauv ntsiav tshuaj yog qhov txwv tsis pub, vim tias nws tau lo nrog daim nyias nyias uas yaj hauv txoj hnyuv.

    Ua ntej pib txoj kev kho mob nrog rau cov tshuaj Rosucard, tus neeg mob yuav tsum ua raws li kev noj haus anticholesterol, thiab kev noj haus yuav tsum nrog rau tag nrho cov chav kawm ntawm kev kho mob nrog statins, raws li cov khoom xyaw nquag - rosuvastatin.

    Tus kws kho mob ib qho zuj zus xaiv cov tshuaj rau txhua tus neeg mob, raws li cov txiaj ntsig ntawm kev sim ntsuas, nrog rau kev cia siab rau tus neeg mob lub cev.

    Tsuas yog kws kho mob, yog tias tsim nyog, paub yuav hloov cov ntsiav tshuaj Rosucard. Koob tshuaj hloov kho thiab hloov chaw ntawm cov tshuaj nrog rau lwm cov tshuaj tshwm sim tsis muaj ntxov dua ob lub lim tiam txij li lub sijhawm muab tshuaj.

    Kev muab tshuaj rau Rosucard noj tshuaj thawj zaug yuav tsum tsis pub ntau tshaj 10.0 milligrams (ib ntsiav tshuaj) ib hnub ib zaug.

    Maj mam, hauv chav kawm ntawm kev kho mob, yog tias tsim nyog, tsis pub dhau 30 hnub, tus kws kho mob txiav txim siab nce qhov ntau ntxiv.

    Txhawm rau txhawm rau nce cov tshuaj txhua hnub ntawm cov tshuaj Rosucard, cov laj thawj hauv qab no xav tau:

    • Daim foos hnyav ntawm hypercholesterolemia, uas yuav tsum tau txhaj tshuaj ntau tshaj plaws ntawm 40.0 milligrams,
    • Yog tias thaum noj tshuaj ntau txog 10.0 milligrams, lipogram pom tias yuav txo qis cov cholesterol. Tus kws kho mob ntxiv qhov ntau npaum ntawm 20.0 milligrams, lossis tam sim ntawd qhov siab tshaj plaws,
    • Nrog rau cov kev mob nyhav heev ntawm lub plawv tsis ua haujlwm,
    • Nrog kev ua tiav qib ntawm pathology, atherosclerosis.

    Qee tus neeg mob, ua ntej nce ntxiv rau ntau npaum, xav tau cov kev mob tshwj xeeb:

    • Yog tias lub siab ua kab mob rau lub siab cov cim kev sib haum rau Tus Menyuam-Pugh nplai ntawm 7.0 cov ntsiab lus, tom qab ntawd nce kev noj tshuaj ntawm Rosucard tsis pom zoo,
    • Yog tias lub raum tsis ua haujlwm, koj tuaj yeem pib siv tshuaj nrog 0.5 ntsiav tshuaj hauv ib hnub, thiab tom qab ntawd koj tuaj yeem maj mam nce cov tshuaj ntau dua rau 20.0 milligrams, lossis txawm tias ntau npaum li cas,
    • Hauv lub raum lub cev tsis ua haujlwm tsis zoo, statins tsis raug tso cai,
    • Qhov mob nyhav rau lub raum hloov khoom nruab nrog. Qhov ntau tshaj ntawm cov tshuaj Rosucard tsis yog kws kho mob sau tseg,
    • Yog tias muaj kev pheej hmoo ntawm pathology, myopathy kuj tseem xav pib nrog 0.5 ntsiav tshuaj thiab koob 40.0 milligrams txwv.
    Koob tshuaj hloov kho thaum khorau cov ntsiab lus ↑

    Xaus

    Cov tshuaj Rosucard tuaj yeem siv rau hauv kev kho mob ntawm cov cholesterol hauv cov ntshav, tsuas yog ua ke nrog kev noj zaub mov noj tshuaj tiv thaiv kab mob ntshav siab.

    Kev tsis ua raws li kev noj haus yuav ncua kev kho kom zoo thiab ua rau muaj kev cuam tshuam tsis zoo ntawm cov tshuaj ntawm lub cev.

    Cov tshuaj Rosucard tuaj yeem siv tsis tau los ntawm kev siv tshuaj rau tus kheej, thiab thaum sau ntawv yuav txwv tsis pub nws tus kheej kho cov tshuaj, ntxiv rau hloov pauv kev kho mob.

    Yuri, 50 xyoo, Kaliningrad: Statins txo qis kuv cov roj khov ua feem nyob hauv peb lis piam. Tab sis tom qab ntawd, qhov Performance index sawv dua, thiab kuv yuav tsum tau coj ib chav kho mob nrog statin ntsiav tshuaj dua.

    Tsuas yog thaum tus kws kho mob tau hloov kuv cov tshuaj yav dhau los rau Rosucard, Kuv pom tau hais tias cov tshuaj no tsis tuaj yeem tsuas coj kuv cov roj (cholesterol) rov qab mus rau qhov qub, tab sis kuj tseem tsis nce ntxiv tom qab ib txoj kev kho.

    Natalia, 57 xyoo, Ekaterinburg: cov cholesterol pib nce siab thaum lub cev ntas, thiab kev noj zaub mov tsis tuaj yeem txo nws. Kuv tau noj cov tshuaj rosuvastatin los tau 2 xyoo. 3 lub hlis dhau los, tus kws kho mob tau hloov kuv cov tshuaj dhau los nrog Rosucard ntsiav tshuaj.

    Kuv xav tias nws cov nyhuv tam sim - Kuv zoo dua thiab kuv xav tsis thoob tias kuv tuaj yeem poob 4 phaus ntawm cov cev hnyav.

    Nesterenko N.A., kws kho plawv, Novosibirsk - Kuv tau sau tshuaj rau cov neeg mob rau kuv cov neeg mob tsuas yog thaum txhua txoj hauv kev txo qis cov roj (cholesterol) tau raug sim lawm thiab muaj kev pheej hmoo siab ntawm kev tsim cardio pathologies, nrog rau atherosclerosis.

    Statins muaj ntau qhov tshwm sim ntawm lub cev, uas cuam tshuam rau lub neej zoo ntawm cov neeg mob.

    Tab sis siv cov tshuaj Rosucard hauv kuv xyaum, Kuv pom tias cov neeg mob yws yws txog qhov tsis zoo ntawm statins. Ua raws li cov lus pom zoo rau kev siv yuav muab rau tus neeg mob nrog qhov tsawg ntawm cov kev tsis zoo ntawm lub cev.

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