AMT vet HTTs (AMIX vet STS)

Kev taw qhia rau kev siv:

Ntshav Qab Zib Hom II, uas cov ntshav qab zib tsis tuaj yeem txhawb tau los ntawm kev poob phaus, kev noj zaub mov zoo, thiab kev tawm dag zog.

Cov koob tshuaj ntawm cov tshuaj tau txiav txim siab raws li kev soj ntsuam ntshav thiab zis rau cov ntshav qab zib. Thawj qhov tshuaj ntawm cov tshuaj yog 1 mg ntawm glimepiride 1 zaug ib hnub. Thaum kev soj ntsuam kom zoo ntawm tus neeg mob tus mob tau tiav lawm, cov tshuaj no tau siv los txhawb kev kho mob. Yog tias kev txaus siab tswj tus mob tus mob tsis tuaj yeem ua tiav, cov koob tshuaj yuav tsum ua tib zoo nce (raws li cov txiaj ntsig ntawm glycemic tswj) txog 2 mg, 3 mg lossis 4 mg ntawm glimepiride ib hnub ib zaug rau 1 txog 2 lub lis piam.

Noj ib qho tshuaj ntawm glimepiride ntau dua 4 mg ib hnub twg muab kev txhim kho tsuas yog hauv cov xwm txheej tshwj xeeb, thiab tau raug txwv tsis pub ua kom nyias muaj nyias. Qhov kev txhaj tshuaj ntau tshaj plaws yog 6 mg ntawm glimepiride ib hnub.

Hauv cov neeg mob uas siv ntau tshaj plaws ntawm kev siv tshuaj txhua hnub ntawm metformin tsis ua rau kom them nyiaj txaus siab ntawm kev noj haus carbohydrate, kev kho kom haum nrog glimepiride tuaj yeem pib ua. Cov koob tshuaj ntawm metformin yuav tsum tau tawm ntawm tib theem, thiab kev kho mob nrog glimepiride yuav tsum tau pib nrog cov koob tshuaj qis, uas yuav tsum maj mam nce mus rau qhov siab tshaj plaws txhua hnub, nyob ntawm seb yuav tsum tau txhaj cov tshuaj metabolic nyiaj. Cov kev kho mob sib xyaw ua ke yuav tsum tau pib los ntawm kev saib xyuas ntawm tus kws kho mob.

Hauv cov neeg mob rau leej twg carbohydrate metabolism tsis tau them rov qab txawm tias tom qab noj ntau tshaj plaws txhua hnub, thaum muaj xwm txheej ceev, koj tuaj yeem pib kho mob nrog cov tshuaj insulin. Cov neeg mob zoo li no yuav tsum tau txuas ntxiv coj cov tshuaj glimepiride yav dhau los thiab tib lub sijhawm pib siv cov tshuaj insulin me me, uas tom qab ntawd maj mam nce zuj zus, feem, cov qib ntawm cov nyiaj metabolic raug them. Cov kev kho mob sib xyaw ua ke yuav tsum tau pib los ntawm kev saib xyuas ntawm tus kws kho mob.

Noj ntau dhau

• Tsis txaus ntawm kev qoj ib ce thiab kev ua kom yuag,
• Yeem tsis txaus siab lossis (tshwj xeeb tshaj yog nyob rau hauv hnub nyoog laus) tsis muaj peev xwm ntawm tus neeg mob mus sab laj nrog kws kho mob,
• Lub raum tsis ua hauj lwm
• Haus dej cawv, tshwj xeeb tshaj yog ua ke nrog tsis noj mov,
• Kev mob siab rau daim siab,
• Qee cov kab mob kev hloov pauv ntawm cov kab mob endocrine uas cuam tshuam rau cov khoom noj metabolism carbohydrate (piv txwv li, adenohypophysial lossis adrenocortical tsis txaus, lub qog ua haujlwm tsis txaus),
• Kev siv ib txhij ntawm lwm cov tshuaj (saib hauv seem "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom kev sib cuam tshuam").

Yog tias cov xwm txheej saum toj no thiab ntu kev kub siab ntawm lub qog ntshav qab zib muaj nyob, koj yuav tsum qhia koj tus kws kho mob tam sim ntawd, vim tias qhov no yuav tau ua tib zoo saib xyuas cov neeg mob. Qhov tseem ceeb uas ua rau muaj kev pheej hmoo ntawm lub qog ntshav qab zib yuav tsum tau txhaj tshuaj rau Amiksu lossis kev kho txhua yam tshuaj .Thov koob tshuaj yuav tsum tau hloov kho yog tias tus neeg mob lub neej hloov pauv lossis kab mob sib kis. Cov tsos mob ntawm tus mob hypoglycemia, uas muaj kev cuam tshuam txog kev tiv thaiv adrenergic, tej zaum yuav luag nyav lossis tsis tuaj kiag li yog tias tus mob hypoglycemia tau maj mam dhau los ntawm cov neeg mob autonomic neuropathy, cov neeg laus. Cov tsos mob kuj tseem tuaj yeem txo qis hauv cov neeg mob uas tau kho ib txhij nrog b-adrenergic blockers nrog reserpine, clonidine, guanethidine, lossis lwm txoj kev. Kev mob ntshav qab zib, nyob rau hauv yuav luag txhua qhov teeb meem, tuaj yeem nres sai sai los ntawm kev noj zaub mov sai sai, xws li cov piam thaj lossis piam thaj (piv txwv, hauv daim ntawv ntawm cov kua qab zib nrog kua txiv qab zib lossis tshuaj yej). Yog li, tus neeg mob yuav tsum coj cov piam thaj tsawg kawg 20 gram qabzib. Khoom qab zib ua rau muaj txiaj ntsig tsis tau muaj txiaj ntsig hauv kev kho ntshav qab zib. Los ntawm cov kev paub dhau los nrog kev siv lwm yam tshuaj sulfanylurea, nws paub tias, txawm hais tias thawj zaug kev vam meej ntawm cov kev kho mob coj los, kev rov ua haujlwm ntawm hypoglycemia yog ua tau. Ua tib zoo saib xyuas thiab kev soj ntsuam ntawm tus neeg mob tus mob yog qhov tsim nyog. Kev mob ntshav nce siab ntau yam yuav tsum tau txais kev kho mob sai raws li kev saib xyuas ntawm tus kws kho mob, thiab nyob rau kis mob hnyav, pw hauv tsev kho mob ntawm tus neeg mob.

Phiv los sis:

Cov tsos mob ntawm tus mob hypoglycemia: xeev siab, kiv taub hau, mob taub hau, ntuav, pw tsaug zog, "hma" qab los noj mov, tsaug zog, tsaug zog, tsis tuaj yeem cuam tshuam ntawm kev saib xyuas, tsis pom kev, qaug dab peg hauv nruab nrab ntawm lub caj dab, poob qis, ntxhov siab, tsis meej pem, hais lus tsis meej, ntxhov siab thiab kev nyuaj siab. Tsis tas li, adrenergic tshua tuaj yeem tshwm sim: tachycardia, mob ntshav siab, txhaws ntswg, tawm hws, ntxhov siab, mob plawv dhia tsis meej thiab mob taub hau. Kev tsis nco qab, tshee viav vias, paresis, tsis hnov ​​mob, tsis paub pab, tsis tuaj yeem tswj tus kheej, ua kom zoo nkauj, nkees nkees thiab tsis nco qab mus txog qhov tsis nco qab, ua pa thiab bradycardia yuav tshwm sim.

Cov duab hauv chav soj ntsuam ntawm kev tawm tsam ntawm lub qog ntshav qab zib tuaj yeem zoo li qhov mob stroke. Tom qab normalizing glycemic lub xeev, tag nrho cov tsos mob no feem ntau ploj.

• Cov kabmob hauv lub cev: thaum lub sijhawm kho (tshwj xeeb hauv thawj theem), qhov pom kev tsis pom kev zoo tuaj yeem tshwm sim, vim qhov kev hloov pauv hauv cov ntshav muaj ntshav qabzib.
• Lub plab zom mov: muaj mob plab zom mov, xws li mob plab thiab zawv plab, ntuav, xeev siab, ib qho kev xav ntawm lub siab lossis phwj ntawm qhov mob plab, tsis tshua muaj mob muaj kev nce siab hauv kev ua haujlwm ntawm daim siab thiab ua rau lub siab ua haujlwm (mob daj thiab mob cholestasis), mob siab, uas tuaj yeem ua rau daim siab ua hauj lwm.
• Kev kaw lus hauv lub cev: muaj teeb meem loj heev yuav tshwm sim. Muaj qee zaus, mob thrombocytopenia thiab, tshwj xeeb, granulocytopenia, hemolytic anemia, leukopenia, erythrocytopenia, agranulocytosis thiab pancytopenia (vim myelosuppression) yog qhov ua tau.
• Lwm yam phiv Kev ua xua lossis pseudo-kev ua xua nyob rau hauv daim ntawv ntawm urticaria, tawm pob lossis khaus tuaj yeem qee zaum tshwm sim. Yog tias khaus qhov mob tshwm sim, sab laj nrog tus kws kho mob tam sim ntawd.

Cov kev xav zoo li no, raws li txoj cai, yog cov me ntsis, tab sis tuaj yeem vam meej, nrog rau dyspnea thiab txo qis hauv ntshav siab kom poob siab. Nyob rau hauv kev sib cais, tej zaum yuav muaj kev nkag siab ntau ntxiv ntawm daim tawv nqaij mus rau qhov kev ua ntawm lub teeb, ua xua vasculitis thiab muaj kev poob qis hauv sodium hauv cov ntshav.

Kev cuam tshuam nrog lwm yam tshuaj thiab dej caw:

Kev siv cov tshuaj Amix nrog qee lwm yam kev npaj kho mob tuaj yeem ua rau qhov tsis txaus siab nce lossis txo qhov cuam tshuam ntawm hypoglycemic ntawm cov tshuaj nquag. Lwm yam tshuaj yuav tsum tau noj tsuas yog tom qab sab laj (lossis raws li qhia) kws kho mob.

Qhov no yuav tsum tau txiav txim siab thaum noj glimepiride nrog CYP2C9 inhibitors (e.g. fluconazole) lossis CYP2C9 inducers (piv txwv li rifampicin).

Cov kev paub ntawm kev kho mob nrog glimepiride lossis lwm yam sulfonylurea derivatives qhia tau tias muaj peev xwm ntawm cov kev sib txuam zoo li no: potentiation ntawm cov nyhuv ntawm txo qis ntshav qabzib. Qee qhov xwm txheej, qhov no ua rau cov ntshav qog ntshav qis thaum noj ib qho ntawm cov tshuaj: phenylbutazone, azapropazone thiab oxyphenbutazone, insulin thiab tshuaj tiv thaiv kab mob hauv lub qhov ncauj, metformin, salicylates ntawm tara-amino salicylic acid, anabolic steroids thiab txiv neej poj niam txiv neej, chloramphenicolinum, antifumorloenram fibrates, ACE inhibitors, fluoxetine, allopurinol, sympatholytics, cyclo-, tri-taifosfamidiv, sulfinpyrazone.

Qhov kev txo qis ntawm qhov tshwm sim ntawm cov tshuaj (qhov txo qis ntawm cov txiaj ntsig ntawm cov ntshav qabzib tsawg dua) los yog nce ntawm cov ntshav qabzib los ntawm cov thawj coj ntawm Amix nrog rau cov tshuaj hauv qab no: estrogen thiab progestogen, saluretics thiab thiazide diuretics, thyre-stimulating tshuaj, glucocorticoids, phenothiazine derivatives, chlorpromazine, adrenaline , nicotinic acid (hauv koob tshuaj loj) thiab nicotinic acid derivatives, laxatives (siv sijhawm ntev), phenytoin, diazoxide, glucagon, barbiturates, rifampicin, aceto amide.

Siv tib lub sij hawm ntawm antagonists ntawm H2-receptors, b-blockers, clonidine thiab reserpine tuaj yeem ua rau potentiation lossis ua kom cov ntshav qis nyob rau hauv lub cev los ntawm kev noj Amiksu. Sympatolytics xws li b-blockers, clonidine, gaunetidine thiab reserpine tuaj yeem npog lossis tshem tawm cov tsos mob ntawm adrenergic teeb meem, uas ua rau lub cev tsis muaj ntshav qab zib. Kev txiav txim siab haus cawv ntau yuav ua rau lub zog ntawm cov ntshav glimepiride tsis muaj kev tiv thaiv zoo. Glimepiride tuaj yeem txhim kho lossis txo cov nyhuv ntawm coumarin derivatives.

Muaj pes tsawg leeg thiab lub zog:

Muaj pes tsawg leeg: 1 ntsiav tshuaj muaj cov tshuaj glimepiride 1.2, 3 lossis 4 mg.

Daim ntawv tso tawm: 1 mg ntsiav tshuaj No. 10x3, No. 10x9, No. 10x12.

Glimepiride yog cov tshuaj nquag ntawm tshuaj, sulfonylurea derivative. Nws yog siv ntawm qhov ncauj, muaj kev txiav txim siab hypoglycemic. Nws txhawb kev tsim tawm cov tshuaj insulin los ntawm beta hlwb ntawm cov txiav, nce qhov rhiab heev ntawm peripheral cov ntaub so ntswg rau insulin, nce insulin tso tawm Tom qab kev tswj hwm qhov ncauj, qhov nqus ntawm glimepiride yog 100%. Kev noj tsis cuam tshuam txog kev siv bioavailability, tab sis tsuas yog me ntsis txo tus nqi ntawm kev nqus. Cmax (kev xav ntau tshaj plaws hauv cov ntshav cov ntshav) tau mus txog 2.5 teev tom qab kev tswj hwm ntawm qhov ncauj (qhov nruab nrab ntawm cov ntshav ntshav yog 0.3 μg / ml thaum noj ntau 4 mg ntawm ib hnub). Muaj txoj kab sib txuas ntawm qhov koob tshuaj thiab Cmax, nrog rau cov koob tshuaj thiab AUC (thaj chaw hauv qab qhov ntsuas-lub sijhawm nkhaus).

Kev faib tawm ntawm glimepiride yog cim los ntawm qhov tsis tshua muaj ntau ntawm kev faib tawm (txog 8,8 litres), uas yog kwv yees li qhov sib npaug ntawm qhov ntim rau albumin, kev tshem tawm tsawg (kwv yees li 48 ml / min.), Qhov siab ntawm kev khi rau plasma protein (> 99%). Biotransformation thiab tshem tawm: nruab nrab plasma ib nrab-lub neej rau glimepiride yog 5 txog 8 teev. Tus nqi no yog qhov tseem ceeb rau kev txiav txim siab cov ntshiab glimepiride ntau tom qab ntau koob. Tom qab noj cov tshuaj loj, muaj qhov nce siab me ntsis ntawm cov ntshav ib nrab-lub sijhawm rau glimepiride tau sau tseg.

Cia rau cov neeg mob: Muab khaws cia rau qhov kub thiab txias txog 30 ° C. Khaws deb ntawm menyuam.

Daim ntawv tso tawm

• Amix 1: cov duab liab dawb lub ncoo muaj cov kab uas pom ntawm ob sab.
• Amix 2: oval cov ntsiav tshuaj ntsuab nrog cov kab sib faib rau ob sab.
• Amix 3: Cov ntsiav tshuaj dawb oval daj nrog cov kab sib faib hauv ob tog.
• Amix 4: oval-puab xiav lub thauv muaj cov kab uas muab faib rau ob tog.

10 ntsiav tshuaj nyob hauv ib lub hlwv - peb, cuaj los yog kaum ob lub hlwv nyob rau hauv lub thawv.

Pharmacodynamics thiab pharmacokinetics

Cov Tshuaj Hauv Tshuaj

Glimepiride Puas yog hypoglycemic tus neeg sawv cev rau cov thawj coj ntawm qhov ncauj (derivative sulfonylureas) Muaj kev xaiv xaiv tshuaj insulin pancreatic B hlwb, txhim kho kev tso tawm tshuaj insulinnce nqaij mos rhiab heev rau cov lwg me me tshuaj insulin.

Cov Tshuaj Pharmacokinetics

Tom qab noj bioavailability glimepiridence 100%. Khoom noj khoom haus tsis cuam tshuam rau qib ntawm nqus, tab sis tsuas yog me ntsis inhibits nws. Qhov siab tshaj plaws hauv ntshav (tsau 2-3 teev tom qab noj.)

Qib ntawm kev khi rau cov ntshav protein yog ntau tshaj li 99%. Ib nrab-lub neej yog 6-8 teev. Metabolized kiag li. Nws tawm hauv cov zis thiab los ntawm txoj hnyuv.

Cov Yuav Tsum Muaj

Mob ntshav qab zib mellitusthawj hom mob ntshav qab zib coma, mob ketoacidosis, cev xeeb tub lossis kev pub misCov. Tsis tas li, cov tshuaj tsis tuaj yeem pom zoo rau cov neeg mob nrog xob deev rau lub Cheebtsam ntawm cov tshuaj, derivatives sulfonylureas lossis rau lwm tus tshuaj sulfa.

Sab sij huam

Kev tsim kho tau ntawm cov tsos mob hauv qab no ntshav qog: "Hma" qab losxeev siab apathyntuav tsaug zog, mob taub hau, ntxhov siab, ntxhov siab,kev tsaug zog ntxhov siab, hnov ​​tsis hnov ​​lus, tsis tshua muaj kev cuam tshuam, tsis meej pem, kev nyuaj siabhais lus tsis txaus, qhov muag pom tsis taus, aphasia, tshee hnyorhiab ntxaug lawm paresiskiv taub hau delirium, nruab nrab crampstsis nco qab bradycardiaCov. Kuj muaj peev xwm adrenergickev tawm tsam: kev nkag siab ntawm kev ntxhov siab, hws, leeg ntshav siabqaug dab peg angina pectoris, tachycardia, arrhythmia.

Los ntawm ntawm saib: pom kev tsis taus ib ntus.

Los ntawm kev zom plab: kev mob plab, xeev siab, ntuav, zoo nkaus li muaj lub cev hauv lub epigastrium, zawv plabkev hloov pauv hauv cov ntsiab lus ntawm daim siab enzymes, kab mob siab.

Los ntawm hematopoiesis: leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, granulocytopenia, erythrocytopenia, pancytopenia.

Lwm yam kev phiv tshuaj: khaus, urticaria, dyspneasiab txo.

Tsawg tsawg zaus, cov hauv qab no kuj tuaj yeem pom: photosensitivity, kev tsis haum vasculitisqib txo sodium hauv cov ntshav.

Cov lus qhia rau siv (Txujci thiab ntau npaum li cas)

Cov mob tseem ceeb rau kev kho kom ua tiav: kev noj zaub mov zoo, kev tawm dag zog lub cev thiab kev saib xyuas cov ntshav thiab zis tas li. Qhov ntau npaum ntawm cov tshuaj tau txiav txim siab los ntawm cov txiaj ntsig ntawm kev tshuaj ntsuam.

Thawj qhov tshuaj ntawm cov tshuaj yog 1 mg glimepiride txhua hnub. Tib koob tshuaj yog siv los txhawb nqa thaum ua tiav kev tswj hwm tus neeg mob tus mob.

Yog tias qhov kev tswj hwm xav tau ntawm tus neeg mob tsis tuaj yeem ua tiav, qhov koob tshuaj tau nce ntxiv los ntawm 1, 3 lossis 2 mg glimepirideib hnub rau txhua txhua ib mus rau ob lub lis piam.

Txais tosglimepiride dhau 4 mg ib hnub twg txhim kho tsuas yog tshwj xeeb. Qhov tshuaj ntau ntau yog txog li 6 mg ntawm cov tshuaj ib hnub.

Hauv cov neeg mob uas tsis muaj nyiaj them rau qhov tsis hnov ​​qab los ntawm cov metabolism hauv plhaws, txawm tias tom qab siv ntau tshaj plaws, kev kho mob tuaj yeem pib tshuaj insulin tsuas yog hais tias tsim nyog kiag li. Cov neeg mob zoo li no yuav tsum tau siv txuas ntxiv ntawm cov tshuaj yav dhau los thiab tib lub sijhawm pib siv cov tshuaj insulin me me, yav tom ntej lawv raug tso cai kom maj mam nce ntxiv raws li theem kev them nyiaj metabolic.

Kev siv tshuaj txhua hnub

Feem ntau nws tau txaus rau lub cev noj ib qho tshuaj txhua hnub ua ntej lossis thaum noj tshais. Yog tias tus neeg mob tsis nco qab noj dua ntxiv, ces yuav tau siv tshuaj ntxiv tsis xav kom nce ntxiv.

Hloov kho koob tom qab

Thaum lub sij hawm kho, ib qho kev nce siab mus rau tshuaj insulin thiab txo qhov xav tau glimepirideCov. Yog li ntawd, los tiv thaiv ntshav qog ntau npaum yuav tsum tau txo kom tsawg lossis siv tshuaj txiav. Nrog rau qhov nce lossis qis dua hauv kev hnyav, kev hloov pauv hauv lub neej lossis qhov zoo li pom ntawm lwm yam uas ua rau muaj kev pheej hmoo ntxiv ntshav qog lossis hyperglycemia, nws yog ib qho tsim nyog los tshuaj xyuas qhov ntau npaum li cas ntawm cov tshuaj.

Kev Hloov los ntawm lwm cov neeg tawm ncauj tawm mus rau kev siv Amix

Hauv qhov xwm txheej no, ib tus yuav tsum coj mus rau hauv tus lej ntawm qhov muaj txiaj ntsig ntawm cov tshuaj ntawm lub cev thiab ib nrab neej. Hauv kev siv dhau los ua lub caij nyoog ntev antidiabetic cov neeg sawv cev nrog lub sijhawm ib nrab-lub neej ntev, nws pom zoo kom pib kho Amix tom qab lub sijhawm tag sijhawm ntawm kev tshem tawm lub sijhawm, txij li muaj cov nyhuv ntxiv tau.

Hloov tawm ntawm cov insulin mus rau amix

Hauv qee qhov tshwj xeeb, thaum qhov mob ntawm cov neeg mob uas muaj ntshav qab zib hom 2 yog tswj hwm tshuaj insulin, qhia yuav tshwm sim hloov mus rau glimepirideCov. Kev hloov mus rau Amix hauv cov neeg mob no yuav tsum tau nqa tawm los ntawm kev saib xyuas ntawm kws kho mob.

Noj ntau dhau

Tom qab overdose ntawm cov tshuaj, cov tsos ntawm ntshav qog, uas tuaj yeem ntev li 12 teev txog 3 hnub. Xav kom mus pw hauv tsev kho mob hauv chav tuam tsev dav dav.Cov tsos mob ntau dhau muaj xws li ntuav lossis xeev ntuav, mob plab, ntxhov siab, qhov muag plooj, tshee hnyo ua kom sib haum muaj teeb meem, tsaug zog, insomnia, tsis nco qabthiab cramps.

Kev siv ntau dhau kev kho mob muaj ua pais plab lav, haus dej, tshuab txais carbon thiab sodium sulfateCov. Tsis tas li, koj yuav tsum pib siv cov piam thaj sai li sai tau. Kev kho ntxiv yuav tsum yog mob.

Kev sib txuam

Thaum muab sib xyaw nrog Phenylbutazone, Azapropazone, Metformin, Oxyphenbutazone, insulin, cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, salicylates, anabolic steroids, androgens, coumarin-type anticoagulants, chloramphenicol, Fenfluramine, fibratins, Acidumoliponofilinfinofinininininininininininininininhypoglycemia yog ua tau.

Thaum siv estrogens, saluretics, progestogens, thiazide diuretics, glucocorticoids, cov thyroid-stimulating tshuaj, phenothiazine derivatives (Adrenaline, Chlorpromazine), sympathomimetics, nicotinic acid thiab nws cov derivatives, laxatives, Phenytoin, Glucagon, Diazoxide, Rifampicin, Barbiturates, Acetosolamidemuaj peev xwm ua kom tsis muaj zog ntawm cov nyhuv ntawm cov tshuaj thiab nce ntxiv hauv cov concentration ntawm cov piam thaj hauv cov ntshav.

Glimepiridehloov cuam tshuam coumarin-xws li cov tshuaj.

Cov lus qhia tshwj xeeb

Thaum pib kho mob, tus neeg mob yuav muaj kev pheej hmoo ntxiv ntshav qog- qhov no yuav tsum tau ua tib zoo saib xyuas nws tus mob. Qhov tseeb ua rau cov ntshav qabzib nyob rau hauv lub ntsej muag tsawg yog: kev noj zaub mov tsis xwm yeem, ua yuam kev ntawm zaub mov, ua kom tsis zoo, noj zaub mov tsis zoo, thiab tsis noj zaub mov zoo.

Amipyrid, Amaril, Glayri, Glemaz, Glianov, Glimaks, Glinova, Glyrid, Dimaril, Diapirid, Altar, Perinel, Elgim.

Tsis muaj kev paub dhau los ntawm kev siv tshuaj yeeb hauv menyuam yaus.

Thaum cev xeeb tub thiab lactation

Cov poj niam cev xeeb tub uas tau siv tshuaj dhau los hloov mus rau kev kho mob tshuaj insulin

Yog tias tus neeg mob xav tau coj tshuaj insulin, nws raug nquahu kom tsis txhob pub lactation.

Cov kev paub ntawm kev siv cov tshuaj tsis txaus los ua lub hom phiaj duab ntawm nws cov hauj lwm zoo. Nyob rau lub sijhawm, qhov ncauj cov tshuaj tiv thaiv ntawm cov tshuaj no siv ntau dua. Raws li pob nyiaj glimepiride yog cov tshuaj ntawm kev xaiv rau mob ntshav qab zib hom thib ob thiab pab cais tawm ntawm kev siv cov tshuaj insulin. Thaum siv cov koob tshuaj pom zoo, kev phiv tsis tshua muaj.

AMT vet HTTs (AMIX vet STS)

Lub npe ua lag luam ntawm cov khoom lag luam tshuaj: AMIX ™ Vet CTZ 150 mg / g (AMIX ™ Vet STS 150 mg / g).

Lub npe txawv tebchaws tsis raws cai: chlortetracycline.
Daim ntawv muab cov koob: hmoov rau kev tswj hwm qhov ncauj.
AMIX ™ Vet XTC 150 mg / g muaj hauv 1 g ua cov khoom xyaw: chlortetracycline - 150 mg (raws li chlortetracycline hydrochloride), raws li cov tshuaj muaj txiaj ntsig: fermentation khoom ntawm Streptomyces aureofaciens thiab hmoov nplej hmoov nplej txog 1 g.
Hauv cov tsos, AMIX ™ Vet XTC 150 mg / g yog hmoov los ntawm lub teeb xim av mus rau xim av tsaus.
AMIX ™ Vet XTC 150 mg / g muaj nyob rau hauv cov ntawv npaj ua ntej-txheej txheej ntawv nyiaj hnab nrog txheej sab hauv ntawm polyethylene lossis ntau txheej ntawv hnab ntawv.
AMIX ™ Vet XTC 150 mg / g yog muab cia rau hauv lub chaw tsim khoom ntim ntim, sib cais los ntawm cov khoom noj thiab pub, hauv qhov chaw qhuav, tsaus ntawm qhov kub ntawm 2 ° C txog 25 ° C.
AMIX et Vet XTC 150 mg / g yuav tsum khaws cia kom tsis txhob ncav cuag cov menyuam.
Cov tshuaj tsis raug siv pov tseg raug pov tseg raws li txoj cai xav tau.

Cov yam ntxwv Pharmacological:

AMIX ™ Vet CTZ 150 mg / g yog cov tshuaj tua kabmob ntawm pawg tetracycline.
Chlortertracycline, uas yog ib feem ntawm cov tshuaj muaj ntau qhov kev pom ntawm cov tshuaj tua kab mob, ua haujlwm tawm tsam cov kab mob gram-positive thiab gram-tsis zoo, suav nrog Escherichia coli, Klebsiella pneumoniae, Proteus spp., Salmonella spp., Staphylococcus spp. Pasteurella multocida, Streptococci ntxiv rau, Rickettsia spp., Chlamydia, Protozoa thiab Mycoplasma spp.
Tus txheej txheem ntawm cov kab mob bacteriostatic muaj txiaj ntsig ntawm cov tshuaj tua kab mob yog los txhawb kev sib txuas ntawm cov kab mob hauv cov kab mob hauv cov kab mob microbial ntawm qib ribosomal, uas tiv thaiv kev faib thiab tsim ntawm phab ntsa cell.
Chlortetracycline tsis nqus ib txoj hnyuv hauv lub plab zom mov. Cov neeg kawm ntawv ntawm kev nqus tau tsawg zuj zus nyob rau hauv muaj cov kua ntsev ntawm ob- thiab trivalent hlau ions uas tetracyclines tsim cov khoom tawg yooj yim. Chlortetracycline khi kom zoo rau cov protein plasma thiab muab faib rau thoob plaws lub cev, kom mus txog rau lub siab tshaj plaws hauv daim siab, tus po, lub ntsws thiab lub chaw nquag ntawm kev tsim cov pob txha. Qhov siab tshaj plaws ntawm tetracycline hauv cov ntshav tau mus txog 4 teev tom qab kev tswj hwm. Txoj kev kho kom zoo ntau rau 12-18 teev. Tetracycline kev xyaum tsis nkag mus rau hauv lub pob txha caj qaum, tab sis nws qib yuav nce ntxiv nrog cov mob o ntawm cov txha caj qaum. Ib nrab-lub neej ntawm chlortetracycline yog 8.8 teev. Nws yog tawm tsuas yog nrog tso zis thiab quav. Nrog quav, nce txog li 10% ntawm tag nrho cov nyiaj ntawm tetracycline uas tau noj tau tuaj yeem tshem tawm.

Daim ntawv thov txheej txheem:

AMIX ™ Vet XTC 150 mg / g yog kws kho mob rau npua, yaj, plab hlaub rau kev kho mob, nqaij qaib rau kev kho mob thiab kho mob rau cov mob thiab mob ntawm cov kab mob ua pa, mob hlwb, mob plab hnyuv thiab lwm yam kab mob thiab lwm yam kab mob ethnologies uas yog vim li cas cov neeg ua haujlwm nkag siab zoo rau chlortetracycline.
AMIX et Vet XTC 150 mg / g txwv tsis pub rau cov neeg laus lub cev nrog kev paub ua kom lub plab zom mov, ua kom nteg qe, nrog rau cov tsiaj muaj mob raum thiab siab tsis txaus.
Thov nrog zaub mov noj hauv ib pawg qauv lossis ib leeg ib hnub ib zaug rau 5-10 hnub.

Pab pawg:
Txhawm rau ntxiv 3.0 - 4.0 kg ntawm yeeb tshuaj rau ib tuj ntawm kev pub sib xyaw (uas sib haum rau 450-600 g ntawm chlortetracycline ib tuj ntawm kev pub mis lossis 20-30 mg / kg ntawm lub cev hnyav).
Txhua hnub cov tshuaj ntawm cov tshuaj muaj qhia hauv lub rooj:

Kev Tiv Thaiv:
Ntxiv 1.5-2.0 kg ntawm cov tshuaj ib tuj ntawm pub sib tov (uas sib xws rau 225-300 g ntawm chlortetracycline / tuj ntawm pub mis lossis 10-15 mg / kg ntawm lub cev hnyav).

Noj ntau dhau

Cov tsos mob ntawm kev haus ib ce tsis tau txheeb xyuas.

Nta:

Qhov tshwj xeeb ntawm kev txiav txim ntawm cov tshuaj thaum nws siv thawj zaug thiab tshem tawm tsis tau teeb tsa.
Hla kev siv tshuaj ntxiv tom ntej yuav tsum raug zam, vim tias qhov no tuaj yeem ua rau txo qis hauv kev kho mob. Yog tias lub sijhawm tau hais tseg rau kev siv tshuaj ntau dua tsis pom, nws yuav tsum siv nrawm dua li qub, nyob rau tib lub zog thiab raws li cov qauv qub.
Cov kev mob tshwm sim, nrog rau qhov tshwj kev mob ntawm ib tus neeg lub siab rau lub hauv paus ntawm cov tshuaj, tsis tau muaj npe. Nrog rau cov tib neeg rhiab heev ntawm cov tsiaj kom chlortetracycline thiab cov tsos ntawm
ntawm kev fab tshuaj tsis haum, kev siv tshuaj AMIKSTM ve XTC 150 mg / g raug tso tseg thiab kho txoj kev kho mob yog nqa tawm.
Tsis txhob siv cov tshuaj AMIX et Vet XTC 150 mg / g hauv kev sib xyaw nrog cov tshuaj tua kab mob (penicillins, cephalosporins, thiab lwm yam), calcium chloride, calcium gluconate, ammonium chloride, antacids, kaolin, npaj muaj hlau, magnesium, calcium thiab aluminium, hauv kev pom ntawm kom tau txo qis hauv nws cov kev ua haujlwm tiv thaiv kab mob.
Kev tua cov nyuj thiab menyuam yaj rau nqaij yog tso cai tsis pub dhau 12 hnub, npua thiab nqaij qaib - 10 hnub tom qab kev siv tshuaj kawg. Cov nqaij ntawm cov tsiaj yuam kom raug tua ua ntej tas sij hawm ntawm lub sijhawm qhia tau tuaj yeem siv rau kev pub tsiaj cov tsiaj.

Kev Tiv Thaiv Tus Kheej

Thaum coj los kho thiab tiv thaiv kev tiv thaiv uas siv cov tshuaj AMIX ™ Vet XTC 150 mg / g, cov kev cai dav dav ntawm kev tu cev thiab kev nyab xeeb txog kev tiv thaiv thaum ua haujlwm nrog cov tshuaj yuav tsum raug pom.
Thaum xaus ntawm kev ua haujlwm, ntxuav koj txhais tes kom huv nrog dej sov thiab xum npum.
Txhua qhov ua haujlwm nrog AMIX ™ Vet XTC 150 mg / g raug nquahu kom siv cov khoom tiv thaiv tus kheej (ntaub da dej, taub hau, hnab looj tes roj hmab, tsom iav kev nyab xeeb, lub tshuab ua pa lossis ntsej muag ntsej muag). Thaum ua haujlwm nrog cov yeeb tshuaj, nws yog txwv tsis pub haus, haus luam yeeb thiab noj zaub mov. Thaum xaus ntawm kev ua haujlwm, koj yuav tsum ntxuav koj lub ntsej muag thiab txhais tes nrog xab npum thiab dej, yaug koj lub qhov ncauj.
Yog tias kis los ntawm cov tshuaj nrog cov tawv nqaij lossis cov qog ua kua ntswg, yaug nws nrog cov dej ntws los ntawm lub cev; yog tias nkag rau hauv koj lub qhov muag, yaug dej tam sim ntawd thiab sab laj nrog kws kho mob yog tias tsim nyog.

Txee lub neej thiab cia:

Lub txee lub neej ntawm cov tshuaj nyob rau hauv cov xwm txheej ntawm kev khaws cia hauv cov khoom ntim tau kaw yog 2 xyoos txij li hnub ntawm ntau lawm, tom qab qhib lub pob - tsis pub ntau tshaj 28 hnub, hauv pub - tsis pub dhau 3 hnub.

Tsis txhob siv cov tshuaj tom qab hnub tas sij hawm.
AMIX ™ Vet XTC 150 mg / g yog muab cia rau hauv lub chaw tsim khoom ntim ntim, sib cais los ntawm cov khoom noj thiab pub, hauv qhov chaw qhuav, tsaus ntawm qhov kub ntawm 2 ° C txog 25 ° C.
AMIX et Vet XTC 150 mg / g yuav tsum khaws cia kom tsis txhob ncav cuag cov menyuam.
Cov tshuaj tsis raug siv pov tseg raug pov tseg raws li txoj cai xav tau.

Tag nrho cov npe thiab cov lus qhia ntawm cov khoom lag luam veterinary tuaj yeem pom hauv cov khoom lag luam ntawm peb lub vev xaib. Hais txog tus nqi, nrog rau kev tuaj yeem yuav koj yuav zoo siab qhia peb cov thawj coj.

Amix muaj pes tsawg leeg

• Ib ntsiav tshuaj ntawm cov tshuaj Amix 1 muaj 1 mg glimepiride.
• Ib ntsiav tshuaj ntawm cov tshuaj Amix 2 muaj 2 mg glimepiride.
• Ib ntsiav tshuaj ntawm cov tshuaj Amix 3 muaj 3 mg glimepiride.
• Ib ntsiav tshuaj ntawm cov tshuaj Amix 4 muaj 4 mgglimepiride.

Cov khoom siv ntxiv: povidone 25, lactose, polysorbate 80, microcrystalline cellulose, crospovidone, silicon dioxide, magnesium stearate, hlau oxide, zas.

Amix - Cov lus qhia rau kev siv

Cov mob tseem ceeb rau kev kho kom ua tiav: kev noj zaub mov zoo, kev tawm dag zog lub cev thiab kev saib xyuas cov ntshav thiab zis tas li. Qhov ntau npaum ntawm cov tshuaj tau txiav txim siab los ntawm cov txiaj ntsig ntawm kev tshuaj ntsuam.

Thawj qhov tshuaj ntawm cov tshuaj yog 1 mg ntawm glimepiride txhua hnub. Tib koob tshuaj yog siv los txhawb nqa thaum ua tiav kev tswj hwm tus neeg mob tus mob.

Yog tias qhov kev tswj hwm xav tau ntawm tus neeg mob tsis tuaj yeem ua tiav, qhov tshuaj ntau dua tau ntxiv 1, 3 lossis 2 mg ntawm glimepiride ib hnub ib zaug rau ib mus rau ob lub lis piam.

Noj glimepiride ntau tshaj 4 mg ib hnub twg muab kev txhim kho tsuas yog tshwj xeeb. Qhov tshuaj ntau ntau yog txog li 6 mg ntawm cov tshuaj ib hnub.

Hauv cov neeg mob uas tsis muaj nyiaj them rau qhov ua rau tsis txaus siab ntawm cov metabolism hauv lub cev, txawm tias tom qab siv ntau tshaj plaws, kev kho tshuaj insulin tsuas yog pib yog tsim nyog tiag tiag. Cov neeg mob zoo li no yuav tsum tau siv txuas ntxiv ntawm cov tshuaj yav dhau los thiab tib lub sijhawm pib siv cov tshuaj insulin me me, yav tom ntej lawv raug tso cai kom maj mam nce ntxiv raws li theem kev them nyiaj metabolic.

Kev siv tshuaj txhua hnub

Feem ntau nws tau txaus rau lub cev noj ib qho tshuaj txhua hnub ua ntej lossis thaum noj tshais. Yog tias tus neeg mob tsis nco qab noj dua ntxiv, ces yuav tau siv tshuaj ntxiv tsis xav kom nce ntxiv.

Hloov kho koob tom qab

Thaum lub sijhawm kho, qhov nce ntawm insulin rhiab heev thiab txo qis qhov xav tau ntawm glimepiride yog ua tau. Yog li, txhawm rau txhawm rau tiv thaiv hypoglycemia, ntau npaum yuav tsum tau txo qis lossis cov tshuaj yuav tsum tau txiav tawm. Nrog rau qhov nce lossis qis dua hauv kev hnyav, kev hloov hauv lub neej, lossis lwm yam uas ua rau muaj kev pheej hmoo ntawm hypoglycemia lossis hyperglycemia, nws yog qhov yuav tsum tau rov qab txiav txim siab qhov ntau npaum li cas ntawm cov tshuaj.

Kev Hloov los ntawm lwm cov neeg tawm ncauj tawm mus rau kev siv Amix

Hauv qhov xwm txheej no, ib tus yuav tsum coj mus rau hauv tus lej ntawm qhov muaj txiaj ntsig ntawm cov tshuaj ntawm lub cev thiab ib nrab neej. Nrog rau kev siv yav dhau los ntawm cov tshuaj tiv thaiv kab mob ntev nrog ib nrab-lub neej ntev, nws pom zoo kom pib kho Amix tom qab tas sij hawm ntawm kev tshem tawm lub sijhawm, txij li cov nyhuv ntxiv tau.

Hloov tawm ntawm cov insulin mus rau amix

Hauv cov xwm txheej tshwj xeeb, thaum qhov xwm txheej ntawm cov neeg mob ntshav qab zib hom 2 yog tswj hwm los ntawm insulin, kev qhia rau kev hloov mus rau glimepiride yuav tshwm sim. Kev hloov mus rau Amix hauv cov neeg mob no yuav tsum tau nqa tawm los ntawm kev saib xyuas ntawm kws kho mob.