Mikstard® 30 NM Lub sijhawm nruab nrab ntev ntawm tib neeg insulin xyaw nrog ua yeeb yam luv luv

Ncua rau lub subcutaneous thawj coj, 100 IU / ml

1 ml ntawm cov tshuaj muaj

cov tshuaj nquag - qhia txog kev kho mob tib neeg cov tshuaj insulin 3.50 mg (100 IU) 1,

tus zam: zinc chloride, glycerin, phenol, metacresol, sodium hydrogen phosphate dihydrate, protamine sulfate, hydrochloric acid 2 M tov, sodium hydroxide 2 M tov, dej rau kev txhaj tshuaj.

1 Cov tshuaj muaj 30% soluble tib neeg cov tshuaj insulin thiab 70% isofan-insulin

Qhov kev tshem tawm dawb, thaum sawv ntsug, yog stratified mus rau hauv lub pob tshab, tsis muaj xim lossis yuav luag tsis muaj xim tsis zoo nkauj tshaj plaws thiab dawb nag lossis daus. Cov nag lossis daus tau yooj yim resuspended nrog maj mam co.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Ib nrab-lub neej ntawm cov tshuaj insulin nyob rau hauv cov hlab ntshav yog ob peb feeb, yog li ntawd, cov yeeb yam kev txiav txim ntawm cov tshuaj insulin yog txiav txim siab tsuas yog nws cov yam ntxwv nqus. Lub sijhawm ntawm kev ua ntawm insulin npaj feem ntau vim yog tus nqi ntawm kev nqus, uas nyob ntawm ntau yam (piv txwv, ntawm qhov koob tshuaj insulin, txoj kev thiab qhov chaw tswj hwm, qhov tuab ntawm subcutaneous rog txheej thiab hom mob ntshav qab zib mellitus). Yog li no, cov chaw muag tshuaj ntawm cov tshuaj insulin yuav raug rau qhov tseem ceeb nruab nrab- thiab kev hloov ntawm ib leeg ntawm ib leeg.

Qhov siab tshaj plaws (Cmax) ntawm cov tshuaj insulin hauv plasma tau tiav hauv 1.5 mus rau 2.5 teev tom qab kev tswj hwm subcutaneous.

Tsis muaj cov lus tshaj tawm los txuas nrog cov ntshav plasma protein tau sau tseg, tsuas yog tshuav ntawm cov tshuaj tiv thaiv rau cov insulin (yog tias muaj).

Tib neeg cov kua dej yog muab pov tseg los ntawm qhov kev ua ntawm insulin protease lossis insulin-cleaving enzymes, thiab kuj tseem yog los ntawm kev ua ntawm cov protein disulfide isomerase. Nws xav tias nyob rau hauv molecule ntawm tib neeg cov tshuaj insulin muaj ntau qhov chaw ntawm cleavage (hydrolysis), txawm li cas los xij, tsis muaj ib yam ntawm cov metabolites uas tau tsim los ntawm kev ua kom tsis muaj kev cuam tshuam.

Ib nrab-lub neej (T½) yog txiav txim siab los ntawm tus nqi ntawm kev nqus ntawm cov nqaij subcutaneous. Yog li, T½ yog qhov ntsuas ntau dua ntawm kev nqus, dua li qhov ntsuas qhov tseeb ntawm kev tshem tawm cov insulin los ntawm ntshav (T½ ntawm insulin los ntawm cov hlab ntshav tsuas yog ob peb feeb). Cov kev tshawb fawb pom tau tias T½ yog li 5-10 teev.

Cov Tshuaj Hauv Tshuaj

Mikstard® 30 NM yog ob qho kev ua yeeb yam insulin tsim los ntawm kev tsim cov kabmob DNA biotechnology siv Saccharomyces cerevisiae lim. Nws cuam tshuam nrog kev tsim tshwj xeeb nyob rau sab nraud cytoplasmic membrane ntawm cov hlwb thiab ua ib qho insulin-receptor complex. Los ntawm kev ua kom zoo ntawm cov kab mob cAMP biosynthesis (hauv cov roj ntsha thiab lub siab ua haujlwm) lossis, nkag mus ncaj qha rau hauv lub cell (leeg), cov insulin-receptor complex txhawb cov txheej txheem intracellular, suav nrog synthesis ntawm cov lej ntawm cov enzymes tseem ceeb (hexokinase, pyruvate kinase, glycogen synthetase, thiab lwm yam). Txo cov ntshav qabzib yog tshwm sim los ntawm kev nce ntxiv hauv nws txoj kev thauj mus los hauv lub cev, kev nqus thiab kev pov tseg ntawm cov nqaij mos, ua kom cov lipogenesis, glycogenogenesis, synthesis protein, txo tus nqi ntawm cov piam thaj los ntawm lub siab, thiab lwm yam.

Cov nyhuv ntawm cov tshuaj Mikstard® 30 NM pib li ntawm ib nrab ib teev tom qab kev tswj hwm, thiab cov txiaj ntsig siab tshaj plaws tau tshwm sim nyob rau hauv 2-8 teev, thaum lub sijhawm tag nrho ntawm kev txiav txim yog li 24 teev.

Tsuas tshuaj thiab tswj hwm

Ua ke npaj cov tshuaj insulin feem ntau yog muab ib zaug lossis ob zaug hauv ib hnub yog tias yuav tsum tau muaj kev pib ceev thiab ntev dua cov teebmeem yuav tsum ua.

Cov koob tshuaj ntawm cov tshuaj tau xaiv ib tus zuj zus, ua raws li qhov xav tau ntawm tus neeg mob. Feem ntau, cov tshuaj insulin yog nyob nruab nrab ntawm 0.3 thiab 1 IU / kg / hnub. Kev xav tau cov tshuaj insulin txhua hnub yuav muaj ntau dua rau cov neeg mob insulin tsis kam (piv txwv li, thaum tiav nkauj tiav nraug, thiab cov neeg mob rog rog), thiab qis dua rau cov neeg mob uas muaj cov insulin endogenous ntau lawm.

Yog tias cov neeg mob ntshav qab zib ua tiav kev tswj glycemic zoo, ces cov teeb meem ntshav qab zib hauv lawv, raws li txoj cai, tshwm sim tom qab. Hauv kev hais txog qhov no, ib qho yuav tsum sib zog ua kom ua tau zoo ntawm cov tswj kev zom zaub mov, tshwj xeeb, lawv ua tib zoo saib xyuas cov ntshav qabzib hauv cov ntshav.

Cov tshuaj tau muab noj 30 feeb ua ntej noj mov lossis noj khoom txom ncauj uas muaj cov carbohydrates.

Rau kev tswj hwm subcutaneous. Nyob hauv ib qho xwm txheej twg yuav tsum tsis txhob muaj tshuaj insulin ncua sijhawm muab tshuaj rau ncaj nruab nrog cev. Mikstard® 30 NM feem ntau yog tswj subcutaneously hauv thaj av ntawm sab xub ntiag phab ntsa. Yog tias qhov no yooj yim, ces kev hno kuj tuaj yeem ua rau hauv tus ncej puab, thaj av gluteal lossis hauv thaj tsam ntawm deltoid leeg ntawm lub xub pwg (subcutaneously). Nrog kev qhia txog cov tshuaj mus rau thaj av ntawm thaj chaw ntawm sab xub ntiag phab ntsa, kev nqus sai tau tiav ntau dua nrog kev qhia rau lwm thaj chaw. Ua kev txhaj tshuaj rau hauv cov tawv nqaij txo qhov kev pheej hmoo ntawm kev nkag mus rau hauv cov leeg nqaij. Nws yog ib qho tsim nyog los hloov qhov chaw txhaj tshuaj tsis pub dhau thaj chaw anatomical thiaj li yuav txo tau kev pheej hmoo ntawm lipodystrophy.

Cov lus qhia rau siv Mikstard® 30 NM, uas yuav tsum tau muab rau tus neeg mob.

Tsis txhob siv Mikstard® 30 NM:

Hauv cov tshuaj insulin.

Yog tias muaj qhov ua xua (qhov tsis haum lub cev) rau tib neeg cov kua dej los yog rau ib qho twg ntawm cov khoom sib xyaw ua rau Mikstard® 30 NM npaj.

Yog tias cov ntshav qog ntshav qab zib pib (cov piam thaj hauv ntshav tsawg).

Yog tias cov tshuaj insulin tsis khaws cia kom raug, lossis yog nws khov

Yog hais tias lub hau tiv thaiv tau ploj lawm lossis nws yog xoob. Txhua lub raj mis muaj qhov thaiv cov yas tiv thaiv.

Yog tias cov tshuaj insulin tsis dhau los ua xim dawb thiab huab tom qab sib tov.

Ua ntej siv Mikstard® 30 Nm:

Kuaj daim ntawv lo kom paub tseeb tias koj siv hom insulin.

Tshem lub hau tiv thaiv.

Kev Siv Tshuaj Yeeb Mikstard® 30 NM

Cov tshuaj Mikstard® 30 NM yog npaj rau kev tswj hwm hauv subcutaneous. Tsis txhob noj cov tshuaj insulin rau txoj leeg ua los yog intramuscularly. Txhua zaus yuav tsum hloov chaw txhaj tshuaj nyob rau thaj tsam anatomical txhawm rau kom txo qis kev phom sij thiab txhaws ntawm qhov chaw txhaj tshuaj. Cov chaw zoo tshaj plaws rau kev txhaj tshuaj yog: pob tw, sab xub pwg lossis xub pwg.

Nco ntsoov siv cov tshuaj insulin rau ntawm qhov ntsuas qhov ntsuas kom ntsuas qhov koob tshuaj hauv cov kev ua.

Kos cua rau hauv cov tub txhaj tshuaj nyob rau hauv qhov uas yuav tsum tau txhaj rau qhov xav tau ntawm cov tshuaj insulin.

Tam sim ntawd ua ntej noj cov tshuaj, yob lub khob ntawm koj xib teg kom txog thaum cov tshuaj insulin yog tusyees dawb thiab huab. Resuspension yog kev yooj yim yog hais tias cov tshuaj muaj chav sov.

Nkag tshuaj insulin hauv qab daim tawv nqaij.

Tuav rab koob nyob hauv qab ntawm daim tawv nqaij tsawg kawg 6 vib nas this kom paub meej tias qhov koob tshuaj ntawm cov tshuaj insulin yog ua tiav.

Cov kab mob tsis haum, tshwj xeeb yog kis thiab nrog kub taub hau, feem ntau ua rau lub cev xav tau cov tshuaj insulin. Kev hloov kho koob tshuaj kuj tseem xav tau yog tias tus neeg mob tau mob concomitant ntawm lub raum, mob siab, ua tsis taus adrenal, lub caj pas pituitary lossis cov thyroid caj pas.

Qhov xav tau kom haum rau kev txhaj tshuaj kuj tuaj yeem tshwm sim thaum hloov lub cev lossis cov neeg mob ib txwm noj. Koob tshuaj yuav tau tuaj yeem hloov kho thaum hloov tus neeg mob los ntawm ib hom tshuaj insulin mus rau lwm tus.

Sab sij huam

Cov kev phiv tshuaj pom nyob rau hauv cov neeg mob thaum kho nrog Mikstard® 30 NM tau ntau dua qhov muaj peev xwm-dhau thiab vim yog kev txiav txim ntawm pharmacological ntawm cov tshuaj insulin.

Cov ntsiab lus hauv qab no yog qhov tseem ceeb ntawm cov zaus ntawm cov tshwm sim tsis zoo uas tau txheeb xyuas thaum lub sijhawm soj ntsuam, uas tau suav tias yog cuam tshuam nrog kev siv tshuaj Mikstard® 30 NM. Tus zaus tau txiav txim siab raws li hauv qab no: tsis ncau (≥1 / 1,000 txog

Cov kev mob cia ntawm cov tshuaj Mikstard ® 30 NM Penfill ®

Txhob nyob ze cov me nyuam.

kev ncua rau kev tswj hwm ntawm 100 IU / ml - 2.5 xyoo.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Tso koj saib

Cov Ntaub Ntawv Tam Sim No Xav Tau Index, ‰

Cov ntawv pov thawj rau npe Mikstard ® 30 NM Penfill ®

Cov khoom pabcuam ua ntej
Khw online
Hais txog tuam txhab
Hu rau cov ntsiab lus

Hu rau tus tshaj tawm:
+7 (495) 258-97-03
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Email: email tiv thaiv
Chaw nyob: Russia, 123007, Moscow, ul. Thib Tsib 5, d.12.

Qhov chaw raug cai ntawm RLS ® Pawg Tuam Txhab. Lub encyclopedia tseem ceeb ntawm cov tshuaj thiab cov khoom muag ntawm cov khw muag tshuaj assortment ntawm Lavxias Internet. Daim ntawv teev cov tshuaj Rlsnet.ru muab cov neeg siv kev nkag mus rau cov lus qhia, tus nqi thiab cov lus piav qhia txog tshuaj, khoom noj khoom haus, khoom siv kho mob, khoom siv kho mob thiab lwm yam khoom lag luam. Daim ntawv qhia pharmacological suav nrog cov ntaub ntawv ntawm kev sib xyaw thiab daim ntawv tso tawm, kev nqis tes ua pharmacological, kev taw qhia rau kev siv, contraindications, kev phiv tshuaj, kev cuam tshuam tshuaj, hom kev siv tshuaj, cov tuam txhab tshuaj. Daim ntawv qhia cov tshuaj muaj nqi rau tshuaj thiab cov khoom lag luam tshuaj hauv Moscow thiab lwm lub nroog Lavxias.

Nws yog txwv tsis pub xa, theej, tshaj tawm cov ntaub ntawv yam tsis tau txais kev tso cai los ntawm RLS-Patent LLC.
Thaum hais cov ntaub ntawv xov xwm luam tawm nyob rau ntawm nplooj ntawv ntawm lub xaib www.rlsnet.ru, qhov txuas mus rau qhov chaw ntawm cov ntaub ntawv xav tau.

Peb nyob hauv kev tes hauj lwm:

Qoob loo.

Kev ua lag luam siv cov ntaub ntawv tsis raug tso cai.

Cov ntaub ntawv yog npaj rau cov kws kho mob.

Mikstard 30 NM yog ob qho kev ua yeeb yam insulin. Cov tshuaj tau los ntawm kev ua kom rov ua cov DNA biotechnology siv cov tshuaj Saccharomycescerevisiae. Nws cuam tshuam nrog lub cell membrane receptors, vim tias ib qho insulin-receptor complex tshwm.

Cov tshuaj cuam tshuam rau cov txheej txheem tshwm sim sab hauv lub hlwb, los ntawm kev ua kom muaj biosynthesis hauv lub siab thiab cov roj ntsha. Ib qho ntxiv, cov cuab yeej txhawb kev ua kom zais ntawm cov enzymes tseem ceeb, xws li glycogen synthetase, hexokinase, pyruvate kinase.

Txo cov ntshav qab zib tau tiav los ntawm kev txav mus rau hauv qhov ntev, txhim kho kev nqus thiab ua tau zoo ntawm cov piam thaj los ntawm cov ntaub so ntswg. Qhov kev txiav txim ntawm insulin yog twb xav tias tom qab ib nrab teev tom qab txhaj tshuaj. Thiab kev tshaj tawm ntau tshaj yog ua tiav tom qab 2-8 teev, thiab lub sijhawm ntawm cov nyhuv yog ib hnub.

Pharmacological cov yam ntxwv, taw qhia thiab sib kis

Mikstard yog insulin ob-theem uas muaj kev ncua ntev ntawm isofan-insulin (70%) thiab kev ua haujlwm sai insulin (30%). Ib nrab-lub neej ntawm cov tshuaj los ntawm cov ntshav yuav siv sij hawm ntau feeb, yog li ntawd, qhov profile ntawm cov tshuaj yog txiav txim siab los ntawm cov yam ntxwv ntawm nws nqus.

Txheej txheem kev nqus nyob ntawm ntau yam. Yog li, nws muaj kev cuam tshuam los ntawm hom kab mob, ntau npaum li cas, thaj chaw thiab txoj kev coj ntawm cov thawj coj, thiab txawm tias cov tuab ntawm cov nqaij mos subcutaneous.

Txij li thaum siv tshuaj yaj yeeb yog biphasic, nws txoj kev nqus tau ob qho tib si kom ntev thiab ceev ceev. Qhov siab tshaj plaws hauv cov ntshav tau tiav tom qab 1.5-2 teev tom qab sc tswj hwm.

Qhov faib tawm ntawm cov insulin tshwm sim thaum nws khi rau cov ntshav protein. Qhov tshwj xeeb yog cov roj ntsha kis mus rau nws ua ntej tsis tau txheeb xyuas nws.

Tib neeg cov insulin yog muab pov tseg los ntawm insulin-qias rau cov ntshav lossis insulin proteases, thiab, tej zaum, los ntawm cov protein disulfide isomerase. Ntxiv rau, thaj chaw tau tshawb pom txog qhov twg hydrolysis ntawm insulin lwg me me tshwm sim. Txawm li cas los xij, cov khoom noj khoom haus metabolites tsim tom qab hydrolysis tsis yog ciaj sia.

Ib nrab-lub neej ntawm cov tshuaj nquag nyob ntawm nws qhov nqus ntawm subcutaneous ntaub so ntswg. Qhov nruab nrab nruab nrab yog 5-10 teev. Tib lub sijhawm, pharmacokinetics tsis yog tshwm sim los ntawm cov yam ntxwv ntsig txog hnub nyoog.

Kev qhia rau kev siv Mikstard insulin yog hom 1 thiab ntshav qab zib hom 2, thaum tus neeg mob txhim kho cov tshuaj tiv thaiv kab mob qab zib.

Cov tshuaj tiv thaiv yog hypoglycemia thiab mob siab dhau.

Thawj qhov uas tsim nyog sau tias qhov tsuas tshuaj yuav tsum yog tus kws kho mob ib leeg zuj zus. Qhov nruab nrab ntawm cov tshuaj insulin rau cov laus ntshav qab zib yog 0.5-1 IU / kg ntawm qhov hnyav rau ib tus menyuam - 0.7-1 IU / kg.

Tab sis nyob rau hauv kev them nyiaj rau tus kab mob, qhov ntau npaum yog qhov tsim nyog los txo cov tshuaj, thiab yog tias muaj kev rog dhau thiab puberty, qhov nce hauv ntim yuav tsim nyog. Ntxiv mus, qhov xav tau rau lub cev hormone tsawg dua nrog tus kab mob hepatic thiab lub raum.

Kev hno yuav tsum tau muab tshuaj rau ib nrab ib teev ua ntej yuav haus cov zaub mov uas muaj cov khoom noj uas muaj carbohydrate. Txawm li cas los xij, nws tsim nyog nco ntsoov tias thaum kis tsis noj mov, kev ntxhov siab thiab ua si lub cev, noj ntau yuav tsum tau kho.

Ua ntej ua cov kev kho insulin, ntau txoj cai yuav tsum paub:

Kev raug txwv tsis pub muab cov tshuaj rau hauv lub cev.
Kev txhaj tshuaj subcutaneous tau ua nyob hauv anterior plab phab ntsa, ncej puab, thiab qee zaum hauv deltoid cov leeg ntawm lub xub pwg lossis pob tw.
Ua ntej cov lus qhia, nws raug nquahu kom ncua daim tawv nqaij, uas yuav txo qhov ntau ntawm qhov sib xyaw kom tau mus rau hauv cov leeg.
Koj yuav tsum paub tias nrog s / c txhaj tshuaj ntawm cov tshuaj insulin rau hauv plab phab ntsa, nws txoj kev nqus tau tshwm sim sai dua nrog kev qhia ntawm cov tshuaj mus rau lwm thaj chaw ntawm lub cev.
Txhawm rau tiv thaiv kev txhim kho ntawm lipodystrophy, qhov chaw txhaj tshuaj yuav tsum tau hloov tas li.

Insulin Mikstard hauv cov hwj yog siv nrog cov kev txhais tau tshwj xeeb muaj qhov kawm tiav tshwj xeeb. Txawm li cas los xij, ua ntej siv cov tshuaj, cov roj hmab nres yuav tsum muab tshuaj tua kab mob. Tom qab ntawd lub raj mis yuav tsum tau txhuam los ntawm xib teg kom txog thaum cov kua hauv nws yuav zoo li niaj hnub thiab dawb.

Tom qab ntawd, ntau npaum li cas ntawm cov huab cua tau kos rau hauv cov koob txhaj tshuaj, zoo ib yam li cov tshuaj ntawm cov tshuaj insulin. Huab cua tau nkag mus rau hauv lub vial, tom qab uas rab koob raug tshem tawm ntawm nws, thiab huab cua tau hloov chaw los ntawm cov koob txhaj tshuaj. Tom ntej no, koj yuav tsum xyuas seb cov koob tshuaj tau raug tso nkag mus.

Kev txhaj tshuaj insulin yog ua tiav zoo li no: tuav daim tawv nqaij nrog ob tus ntiv tes, koj yuav tsum tho nws thiab maj mam qhia qhov kev daws teeb meem. Tom qab qhov no, lub koob yuav tsum tau tuav hauv qab daim tawv nqaij ntev li 6 feeb thiab tshem tawm. Txhaum ntshav, qhov chaw txhaj tshuaj yuav tsum nias nrog koj tus ntiv tes.

Nws tsim nyog sau cia tias cov hwj muaj cov kaus mom tiv thaiv yas uas tau muab tshem tawm ua ntej cov tshuaj insulin.

Txawm li cas los xij, ua ntej nws tsim nyog xyuas seb lub hau npog nruj npaum li cas rau lub hwj, thiab yog tias nws ploj lawm, ces cov tshuaj yuav tsum tau rov qab mus rau lub tsev muag tshuaj.

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov ntshav qab zib feem ntau nqis los rau qhov tseeb tias nws yooj yim tshaj plaws los siv Mixtard 30 FlexPen.

Qhov no yog ib qho tshuaj insulin syringe cwj mem nrog cov koob tshuaj xaiv, nrog uas koj tuaj yeem teeb qhov ntau npaum li ntawm 1 txog 60 units hauv qhov nce ntawm ib chav.

Flexpen yog siv nrog NovoFayn S koob, qhov ntev uas yuav tsum txog 8 hli. Ua ntej siv, koj yuav tsum tshem lub hau ntawm cov koob txhaj tshuaj thiab paub tseeb tias daim cartridge muaj tsawg kawg yog 12 PIECES ntawm cov tshuaj hormones. Tom ntej no, daim duab xaum xim yuav tsum tau ua kom zoo zoo txog 20 zaus kom txog rau thaum lub txim yuav tsum muaj huab thiab dawb.

Tom qab ntawd, koj yuav tsum tau ua cov theem nram qab no:

Cov roj hmab nyias kho tau nrog cawv.
Daim paib kev nyab xeeb raug tshem tawm ntawm rab koob.
Lub koob txhaj kiav txhab ntawm Flexpen.
Huab cua yog tshem tawm los ntawm daim cartridge.

Txhawm rau kom paub meej ntawm kev txhaj tshuaj tshwj xeeb thiab tiv thaiv huab cua nkag, ntau yam kev coj ua tsim nyog. Ob chav yuav tsum tau teeb tsa kev txhaj tshuaj syringe. Tom qab ntawd, tuav lub Mikstard 30 FlexPen nrog rab koob nce, koj yuav tsum maj mam muab coj mus rhaub lub taub ntim ob peb zaug nrog koj tus ntiv tes kom cov cua txhawm rau hauv nws qhov siab kawg.

Tom qab ntawd, tuav tus cwj mem syringe hauv txoj hauj lwm ncaj, nias lub khawm pib. Nyob rau lub sijhawm no, lub koob xaiv tshuaj yuav tsum tig mus rau qhov xoom, thiab qhov kev daws teeb meem yuav tshwm sim tom kawg ntawm rab koob. Yog tias qhov no tsis tshwm sim, tom qab ntawd koj yuav tsum hloov lub rab koob lossis lub cuab yeej nws tus kheej.

Ua ntej, cov koob xaiv xaiv tau muab teem rau xoom, thiab tom qab ntawd cov koob tshuaj xav tau yog teeb tsa.Yog tias cov xaiv tau tig los txo cov koob tshuaj, nws yog qhov yuav tsum tau saib xyuas lub pob pib, vim tias yog nws tau chwv, ces qhov no tuaj yeem ua rau cov tshuaj insulin to.

Nws tsim nyog sau cia tias los tsim ib qho koob tshuaj, koj siv tsis tau cov nplai ntawm cov nqi ntawm kev ncua uas tseem tshuav. Ntxiv mus, qhov koob tshuaj ntau dhau tus naj npawb ntawm cov seem hauv daim laub ntawv tsis tau teeb tsa.

Mikstard 30 FlexPen yog tswj hwm nyob rau hauv daim tawv nqaij tib yam li Mikstard hauv vials. Txawm li cas los xij, tom qab qhov no, tus cwj mem syringe tsis pov tseg, tab sis tsuas yog cov koob tawm xwb. Txhawm rau ua qhov no, nws kaw nrog lub hau loj loj thiab unscrewed, thiab tom qab ntawd ua tib zoo muab pov tseg.

Yog li, rau txhua qhov txhaj tshuaj, koj yuav tsum siv rab koob tshiab. Tom qab txhua qhov, thaum qhov kub hloov pauv, insulin tsis tuaj yeem los ntawm.

Thaum hle thiab pov tseg cov koob tshuaj, nws yog qhov yuav tsum tau ua raws li kev tiv thaiv kev nyab xeeb kom cov kws kho mob lossis cov neeg muab kev kho mob rau cov ntshav qab zib tsis tuaj yeem tsim kev phom sij rau lawv. Thiab qhov twb siv Spitz-kov yuav tsum tau muab pov tseg yam tsis muaj rab koob.

Txhawm rau siv ntev thiab kev nyab xeeb ntawm cov tshuaj Mikstard 30 Flexpen, nws yog qhov tsim nyog los saib xyuas nws kom zoo, saib txoj cai khaws cia. Tom qab tag nrho, yog tias cov cuab yeej deformed lossis ua puas lawm, ces cov tshuaj insulin tuaj yeem tawm hauv nws.

Nws yog qhov tsim nyog tias FdeksPen tsis tuaj yeem rov ua tiav. Ua ntu zus, cov chaw uas txhaj tshuaj yuav tsum ntxuav. Rau lub hom phiaj no, nws yog wiped nrog paj rwb ntaub plaub soaked nyob rau hauv cawv.

Txawm li cas los xij, tsis txhob ntub, ntxhua, los yog nqus cov cuab yeej hauv ethanol. Tom qab tag nrho, qhov no tuaj yeem ua kev puas tsuaj rau cov koob txhaj tshuaj.

Overdose, kev sib txuam tshuaj, kev phiv tshuaj

Txawm hais tias qhov tseeb hais tias lub tswvyim ntawm kev haus dej cawv ntau dhau tsis tau tsim los rau cov tshuaj insulin, nyob rau qee kis tom qab txhaj tshuaj hypoglycemia yuav tshwm sim muaj ntshav qab zib mellitus, tom qab ntawd nrog kev txo qis hauv qab zib koj yuav tsum haus dej qab zib los noj cov khoom uas muaj cov carbohydrate. Yog li, nws tau hais kom cov neeg mob ntshav qab zib ib txwm nqa ib qho khob noom lossis ib qho piam thaj nrog lawv.

Hauv cov ntshav khov ntau heev, yog tias tus mob ntshav qab zib tsis nco qab lawm, tus neeg mob tau txhaj nrog glucagon hauv qhov npaum li ntawm 0.5-1 mg. Hauv cov tsev kho mob, cov kua nplaum nyob hauv cov tshuaj rau cov leeg ntshav, tshwj xeeb yog tias ib tus neeg tsis muaj tshuaj tiv thaiv rau glucagon tsis pub dhau 10-15 feeb. Txhawm rau tiv thaiv kom rov huam mob, tus neeg mob uas rov qab nco qab xav tau noj carbohydrates hauv.

Qee cov tshuaj ua rau cov metabolism hauv qabzib. Yog li no, thaum txiav txim siab cov tshuaj insulin, qhov no yuav tsum raug coj los txiav txim.

Yog li, cov nyhuv ntawm cov tshuaj insulin cuam tshuam los ntawm:

Kev haus cawv, cov tshuaj hypoglycemic, salicylates, ACE inhibitors, MAO uas tsis yog kev xaiv B-blockers - txo qhov xav tau rau lub cev.
B-blockers - lub npog qhov ncauj ntawm hypoglycemia.
Danazole, thiazides, kev loj hlob hormone, glucocorticoids, b-sympathomimetics thiab cov thyroid hormones - ua rau muaj kev xav tau ntau ntxiv.
Cawv - ua ntev lossis txhim kho qhov kev ua haujlwm ntawm insulin npaj.
Lancreotide lossis Octreotide - tuaj yeem ua rau ob leeg nce thiab txo cov nyhuv tshuaj insulin.

Feem ntau, cov kev mob tshwm sim tom qab thov Mikstard tshwm sim nyob rau hauv cov ntaub ntawv ntawm cov tshuaj tsis yog, uas ua rau lub cev tsis muaj ntshav thiab tsis muaj zog. Kev poob qis hauv cov piam thaj hauv qab no tshwm sim nrog kev siv ntau dhau, uas nrog ua ke nrog hauv nriaj, tsis nco qab thiab cuam tshuam rau lub hlwb ua haujlwm.

Cov kev mob tshwm sim tsawg tsawg suav nrog kev o, retinopathy, peripheral neuropathy, lipodystrophy thiab tawv nqaij ua pob (urticaria, tawm pob).

Kev tsis sib haum xeeb ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous kuj tuaj yeem tshwm sim, thiab cov tshuaj tiv thaiv hauv zos tsim ntawm thaj chaw txhaj tshuaj.

Yog li lipodystrophy mob ntshav qab zib tsuas tshwm sim yog tias tus neeg mob tsis hloov chaw rau kev txhaj tshuaj. Cov tshuaj tiv thaiv hauv zos muaj xws li hematomas, liab, o, o thiab khaus uas tshwm sim hauv thaj chaw txhaj tshuaj. Txawm li cas los xij, kev tshuaj xyuas cov ntshav qab zib tau hais tias cov kev tshwm sim no dhau ntawm lawv tus kheej nrog kev kho mob txuas ntxiv.

Nws yog tsim nyog sau cia tias nrog kev txhim kho sai ntawm glycemic tswj, tus neeg mob yuav muaj tus mob huam thim rov qab. Cov kev mob tshwm sim tsawg tshaj plaws suav nrog kev poob siab anaphylactic thiab hnov tsis pom kev uas tshwm sim thaum pib kho. Txawm li cas los xij, kev tshuaj xyuas ntawm cov neeg mob thiab kws kho mob tau lees tias cov kev mob no yog dhau los thiab ib ntus.

Cov tsos mob ntawm kev ua kom lub cev tsis haum lub cev yuav ua rau lub cev tsis ua haujlwm ntawm lub plab zom mov, ua pob rau ntawm daim tawv nqaij, ua pa ceev, khaus, txhaws qa, mob caj dab, mob ntshav qis thiab ntshav siab. Yog tias cov tsos mob zoo li no tshwm sim, koj yuav tsum sab laj nrog kws kho mob, vim tias kev kho tsis tuaj yeem tuaj yeem ua rau tuag taus.

Tus nqi ntawm cov tshuaj Mikstard 30 NM yog li 660 rubles. Tus nqi ntawm Mikstard Flexpen yog qhov sib txawv. Yog li, syringe cwjmem raug nqi los ntawm 351 rubles, thiab daim cartridges los ntawm 1735 rubles.

Cov tshuaj tiv thaiv zoo tshaj plaws ntawm biphasic insulin yog: Bioinsulin, Humodar, Gansulin thiab Insuman. Mikstard yuav tsum tau muab cia rau hauv qhov chaw tsaus rau tsis pub ntev tshaj 2.5 xyoos.

Daim vis dis aus hauv tsab xov xwm no qhia cov txheej txheem rau kev siv tshuaj insulin.

Kev faib tawm ATX: A10AD01 Insulin (tib neeg)
Mnn lossis pab pawg npe: Human Insulin
Pharmacological pawg:
Chaw tsim tshuaj paus: Tsis paub
Daim Ntawv Tso Cai Tus Tswv: Tsis paub
Tebchaws: Tsis paub

Qhia ntawv kho mob

tshuaj ntsuab tshuaj

Mikstard® 30 nm

Lub npe Kev Lag Luam

Lub Npe Tsis Muaj Npe International

Dosage daim ntawv

Ncua rau lub subcutaneous thawj coj, 100 IU / ml

Muaj pes tsawg leeg

1 ml ntawm cov tshuaj muaj

cov tshuaj nquag - qhia txog kev kho mob tib neeg cov tshuaj insulin 3.50 mg (100 IU) 1,

tus zam: zinc chloride, glycerin, phenol, metacresol, sodium hydrogen phosphate dihydrate, protamine sulfate, hydrochloric acid 2 M tov, sodium hydroxide 2 M tov, dej rau kev txhaj tshuaj.

1 Cov tshuaj muaj 30% soluble tib neeg cov tshuaj insulin thiab 70% isofan-insulin

Kev piav qhia

Cov tshuaj pab pawg kho mob

Insulin thiab analogues, kev txiav txim siab nruab nrab hauv kev sib xyaw nrog kev siv lub zog insulin.

PBX code A10AD01

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Kev siab tshaj plaws (C_max) plasma ntshav insulin tuaj txog hauv 1.5 - 2.5 teev tom qab kev tswj hwm subcutaneous.

Tsis muaj cov lus tshaj tawm los txuas nrog cov ntshav plasma protein tau sau tseg, tsuas yog tshuav ntawm cov tshuaj tiv thaiv rau cov insulin (yog tias muaj).

Ib nrab-lub neej (T½) yog txiav txim siab los ntawm tus nqi ntawm kev nqus ntawm cov nqaij subcutaneous. Yog li T_½ theej, nws yog ntsuas ntawm kev nqus, thiab tsis yog qhov kev ntsuas ntawm kev tshem tawm cov insulin los ntawm ntshav (T_½ tshuaj insulin los ntawm cov hlab ntshav tsuas yog ob peb feeb). Cov kev tshawb fawb pom tau tias T_½ yog li 5-10 teev.

Cov Tshuaj Hauv Tshuaj

Kev ntsuas rau siv

- kev kho mob ntshav qab zib

Tsuas tshuaj thiab tswj hwm

Ua ke npaj cov tshuaj insulin feem ntau yog muab ib zaug lossis ob zaug hauv ib hnub yog tias yuav tsum tau muaj kev pib ceev thiab ntev dua cov teebmeem yuav tsum ua.

Cov tshuaj tau muab noj 30 feeb ua ntej noj mov lossis noj khoom txom ncauj uas muaj cov carbohydrates.

Rau kev tswj hwm subcutaneous. Nyob hauv ib qho xwm txheej twg yuav tsum tsis txhob muaj tshuaj insulin ncua sijhawm muab tshuaj rau ncaj nruab nrog cev. Mikstard ® 30 NM feem ntau yog tswj subcutaneously hauv thaj av ntawm anterior plab phab ntsa. Yog tias qhov no yooj yim, ces kev hno kuj tuaj yeem ua rau hauv tus ncej puab, thaj av gluteal lossis hauv thaj tsam ntawm deltoid leeg ntawm lub xub pwg (subcutaneously). Nrog kev qhia txog cov tshuaj mus rau thaj av ntawm thaj chaw ntawm sab xub ntiag phab ntsa, kev nqus sai tau tiav ntau dua nrog kev qhia rau lwm thaj chaw. Ua kev txhaj tshuaj rau hauv cov tawv nqaij txo qhov kev pheej hmoo ntawm kev nkag mus rau hauv cov leeg nqaij. Nws yog ib qho tsim nyog los hloov qhov chaw txhaj tshuaj tsis pub dhau thaj chaw anatomical thiaj li yuav txo tau kev pheej hmoo ntawm lipodystrophy.

Cov lus qhia rau siv Mikstard® 30 NM, uas yuav tsum tau muab rau tus neeg mob.

Tsis txhob siv Mikstard® 30 NM:

Hauv cov tshuaj insulin.
Yog tias muaj qhov ua xua (qhov tsis haum lub cev) rau tib neeg cov kua dej los yog rau ib qho twg ntawm cov khoom sib xyaw ua rau Mikstard® 30 NM npaj.
Yog tias cov ntshav qog ntshav qab zib pib (cov piam thaj hauv ntshav tsawg).
Yog tias cov tshuaj insulin tsis khaws cia kom raug, lossis yog nws khov
Yog hais tias lub hau tiv thaiv tau ploj lawm lossis nws yog xoob. Txhua lub raj mis muaj qhov thaiv cov yas tiv thaiv.
Yog tias cov tshuaj insulin tsis dhau los ua xim dawb thiab huab tom qab sib tov.

Ua ntej siv Mikstard® 30 Nm:

Kuaj daim ntawv lo kom paub tseeb tias koj siv hom insulin.
Tshem lub hau tiv thaiv.

Kev Siv Tshuaj Yeeb Mikstard® 30 NM

Nco ntsoov siv cov tshuaj insulin rau ntawm qhov ntsuas qhov ntsuas kom ntsuas qhov koob tshuaj hauv cov kev ua.
Kos cua rau hauv cov tub txhaj tshuaj nyob rau hauv qhov uas yuav tsum tau txhaj rau qhov xav tau ntawm cov tshuaj insulin.
Tam sim ntawd ua ntej noj cov tshuaj, yob lub khob ntawm koj xib teg kom txog thaum cov tshuaj insulin yog tusyees dawb thiab huab. Resuspension yog kev yooj yim yog hais tias cov tshuaj muaj chav sov.
Nkag tshuaj insulin hauv qab daim tawv nqaij.
Tuav rab koob nyob hauv qab ntawm daim tawv nqaij tsawg kawg 6 vib nas this kom paub meej tias qhov koob tshuaj ntawm cov tshuaj insulin yog ua tiav.

Cov kev phiv tshuaj pom nyob rau hauv cov neeg mob thaum kho nrog Mikstard® 30 NM tau ntau dua qhov muaj peev xwm-dhau thiab vim yog kev txiav txim ntawm pharmacological ntawm cov tshuaj insulin.

Lub Npe: Mikstard 30 NM Penfill (Mixtard 30 HM Penfill)

Tso tawm daim ntawv, muaj pes tsawg leeg thiab pob

Kev ncua rau kev tswj hwm sc ntawm 1 ml ib qho kev sib xyaw ntawm tib neeg lub cev insulin thiab kev ncua ntawm isofan insulin 100 IU insulin tib neeg soluble 30% isofan insulin ncua ntawm 70%.

Cov chaw kuaj mob thiab chaw muag tshuaj: tib neeg cov tshuaj lom neeg ntawm lub sijhawm nruab nrab.

Mikstard 30 NM Penfill yog kev ncua ntawm biosynthetic tib neeg isofan insulin ntawm biphasic kev ua. Qhov pib ntawm kev ua yog tom qab 30 feeb tom qab subcutaneous thawj coj. Cov txiaj ntsig siab tshaj plaws tsim tawm ntawm 2 teev mus rau 8 teev. Lub sijhawm ua haujlwm tau ntev txog 24 teev Cov ntaub ntawv ntawm qhov kev ua haujlwm ntawm insulin yog kwv yees: nws nyob ntawm qhov koob tshuaj ntawm cov khoom thiab xav txog qee tus yam ntxwv.

Qhov nqus ntawm insulin thiab, vim li ntawd, qhov pib ntawm qhov ua rau lub ntsej muag hypoglycemic, nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), ntim tshuaj, insulin concentration thiab qee yam. Hauv cov ntshav, T1 / 2 ntawm insulin yog ob peb feeb.

Yog li, qhov profile ntawm insulin kev ua yog tsuas yog nyob ntawm tus nqi ntawm nws txoj kev nqus. Muaj ntau ntau yam ua cuam tshuam rau tus txheej txheem no, vim qhov kev sib txawv uas tseem ceeb rau cov tib neeg muaj peev xwm. Thaum hloov pauv los ntawm ib qho tshuaj insulin ntawm 40 PIECES / ml rau 100 PIECES / ml, kev hloov me me ntawm kev nqus ntawm insulin vim tias lub ntim me dua yog nyiaj tau los ntawm nws cov kev xav ntau dua.

Nws raug nquahu kom siv cov tshuaj insipins biphasic nrog cov chav ntshav qab zib kom ruaj khov.

Cartridge Cov Lus Siv

Penfill thiab Khoom Taw Qhia

Ua ntej yuav ntxig tus cwj mem Penfill rau hauv daim ntaub qhwv lub tes tsho, nws yuav tsum tau tsej thiab poob. Cov kev txav yuav tsum ua nyob rau hauv xws li txoj kev uas lub khob pob hauv lub laub yuav txav ntawm ib kawg mus rau lwm qhov. Qhov kev tswj hwm no yuav tsum tau rov ua dua tsawg kawg 10 zaug - kom txog thaum cov kua ua huab li huab thiab dawb.

Yog tias Penfill daim cartridge twb tau ntxig rau hauv tus xaum xaum, rov ua qhov txheej txheem sib xyaw ua ntej txhua qhov kev txhaj tshuaj tom ntej. Tom qab txhaj, koob yuav tsum nyob twj ywm hauv qab ntawm daim tawv nqaij tsawg kawg yog 6 feeb. Lub tes tsho xuas tes xoos yuav tsum tau nias cia kom txog thaum rab koob raug tshem tawm hauv qab ntawm daim tawv nqaij. Tom qab txhaj txhua, koob yuav tsum tau muab tshem tawm sai li sai tau. Penfill yog rau kev siv tus kheej nkaus xwb. Tus cwj mem Penfill tuaj yeem siv tau hauv NovoPen 3, Innovo koob txhaj tshuaj lossis nqa nrog koj kom ntev li 1 lub hlis. Thaum tus cartridge tso rau hauv NovoPen 3 koob txhaj tshuaj, lub thawv xim yuav tsum pom ntawm lub qhov rais ntawm tus sau lub taub.

Cov kev mob tshwm sim cuam tshuam nrog cov nyhuv ntawm cov metabolism hauv cov pluas noj: hypoglycemic tej yam kev mob (pallor, nce tawm hws, palpitations, pw tsaug zog tsis meej, tshee).

Ua xua: tsis nquag - pob khaus ntawm daim tawv nqaij, tsis tshua muaj tshwm sim - mob hlwb. Cov tshuaj tiv thaiv hauv zos: tsis ntau dhau - hyperemia thiab khaus ntawm qhov chaw txhaj tshuaj ntawm cov khoom, nrog siv ntev tsis siv ntau zaus - lipodystrophy ntawm qhov chaw txhaj tshuaj.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub thiab lactation, tus neeg mob xav tau cov tshuaj insulin hloov, uas yuav tsum tau coj mus rau hauv kev tswj hwm kev tswj hwm metabolic txaus. Cov tshuaj Insulin tsis hla qhov chaw tiv thaiv. Thaum siv cov khoom Mikstard 30 NM Penfill thaum lactation, tsis muaj kev pheej hmoo rau tus menyuam.

Cov neeg mob uas tau txais ntau dua 100 IU ntawm cov tshuaj insulin ib hnub yuav tsum tau pw hauv tsev kho mob thaum hloov cov khoom lag luam. Kev hloov pauv ntawm ib hom tshuaj insulin mus rau lwm qhov yuav tsum tau ua nyob ntawm kev tswjhwm ntawm cov ntshav nyob rau qib. Nyob rau hauv kev cuam tshuam ntawm insulin, kam rau ua cawv kom tsawg.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tom qab tus neeg mob hloov mus rau biosynthetic tib neeg insulin, lub peev xwm tsav tsheb thiab koom nrog lwm yam kev muaj feem phom sij uas xav tau kev nce siab ntxiv thiab ceev ntawm psychomotor cov kev cuam tshuam yuav ploj mus ib ntus.

Cov tsos mob: thawj cov tsos mob ntawm tus mob ntshav qab zib tsawg - nce tawm hws sai heev, mob tawm hws, tshee tshee, tshaib plab, ntxhov siab, mob plab hnyuv hauv qhov ncauj, pallor, mob taub hau, pw ntxhov. Nyob rau hauv loj mob ntawm overdose - coma.

Kev Kho Mob: tus neeg mob tuaj yeem tshem tawm qhov mob ntshav qab zib me me los ntawm kev noj cov suab thaj lossis zaub mov muaj suab thaj. Hauv cov xwm txheej loj, subcutaneous lossis intramuscularly muab 1 mg ntawm glucagon. Yog tias tsim nyog, kev kho mob txuas ntxiv iv nrog kev qhia txog kev siv tshuaj dextrose daws teeb meem.

Cov nyhuv tshuaj tiv thaiv kab mob ntshav yog ua kom zoo dua qub los ntawm MAO inhibitors, tsis-xaiv cov beta-blockers, sulfonamides, anabolic steroids, tetracyclines, clofibrate, cyclophosphamide, fenfluramine, thiab cov khoom muaj ethanol.

Cov tshuaj tiv thaiv tawm tsam, glucocorticoids, cov thyroid hormones, thiazide diuretics, heparin, cov khoom lag luam lithium, tricyclic antidepressants txo cov nyhuv hypoglycemic ntawm insulin. Hauv qab ntawm reserpine thiab salicylates, ob qho tib si qaug zog thiab txhim kho kev ua ntawm insulin yog ua tau.

Ethanol, ntau yam tshuaj tua kab mob tuaj yeem txo qhov kev lom neeg lom neeg ntawm insulin.

Cia li thiab sijhawm

Mem hluav roj cartridge yuav tsum muab ntim rau hauv ntim rau hauv qhov chaw tiv thaiv los ntawm tshav ntuj ntawm qhov kub ntawm 2 ° txog 8 ° C, tsis txhob khov.

Kev siv tus cartridge Penfill tsis pom zoo kom muab cia rau hauv lub tub yees.

Saib xyuas!
Ua ntej thov cov tshuaj “Mixtard 30 NM Penfill” nws yog ib qho tsim nyog yuav tsum sab laj ib tus kws kho mob.
Cov kev qhia ntawv yog qhia nkaus xwb kom paub txog koj tus kheej " Mikstard 30 NM Penfill (Mixtard 30 HM Penfill)».

Npaj: MIXTARD ® 30 Nm PENFILL ® (MIXTARD ® 30 HM PENFILL ®)

Cov khoom siv nquag: biphasic isophane insulin txhaj
ATX Code: A10AD01
KFG: Nruab Nrab Sij Hawm Rau Tib Neeg Qhov Insulin
Cov cim ICD-10 (taw qhia): E10, E11
Reg. tus lej: P No. 014312 / 02-2003
Hnub sau npe: 06.16.03
Tswv reg reg. doc .: NOVO NORDISK (Denmark)

DOSAGE FORM, COMPOSITION THIAB PACKAGING

3 ml - cartridges (5) rau NovoPen syringe cwjmem - contour cell ntim (1) - pob khoom los ntawm cardboard.

LUS QHIA RAU KEV SIV RAU SPECIALISTS.
Kev piav qhia ntawm cov tshuaj tau pom zoo los ntawm cov kws tsim khoom hauv xyoo 2004

PHARMACOLOGICAL NKAUS

Mikstard 30 NM Penfill yog kev ncua ntawm biosynthetic tib neeg isofan insulin ntawm biphasic kev ua. Qhov pib ntawm kev ua yog 30 feeb tom qab subcutaneous tswj hwm. Qhov siab tshaj plaws tau tshwm sim ntawm 2 teev thiab 8 teev Lub sijhawm ua haujlwm tau ntev txog 24 teev.

Cov ntaub ntawv ntawm insulin kev txiav txim siab kwv yees: nws nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj thiab qhia txog qee tus yam ntxwv.

PHARMACOKINETICS

Hauv ntshav T_1/2 cov tshuaj insulin yog ob peb feeb. Yog li, qhov profile ntawm insulin kev ua yog tsuas yog nyob ntawm tus nqi ntawm nws txoj kev nqus. Muaj ntau ntau yam ua cuam tshuam rau tus txheej txheem no, vim qhov kev sib txawv uas tseem ceeb rau cov tib neeg muaj peev xwm.

Thaum hloov pauv los ntawm ib qho tshuaj insulin ntawm 40 PIECES / ml rau 100 PIECES / ml, kev hloov me me ntawm kev nqus ntawm insulin vim tias lub ntim me dua yog nyiaj tau los ntawm nws cov kev xav ntau dua.

KEV LAG LUAM

- mob ntshav qab zib insulin-hom mob ntshav qab zib hom (hom I),

- Cov mob ntshav qab zib tsis yog-insulin-hom mob ntshav qab zib (hom II): theem ntawm kev tawm tsam cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, ib feem tawm tsam cov tshuaj no (thaum siv tshuaj los kho), cov kab mob sib kis, kev khiav haujlwm, cev xeeb tub.

CEEV HOM

Nws raug nquahu kom siv cov tshuaj insipins biphasic nrog cov chav ntshav qab zib kom ruaj khov. Nrog cov ntshav qab zib tsis-insulin-mob ntshav qab zib mellitus, raws li txoj cai, siv Mikstard 30 NM Penfill.

Cov koob tshuaj ntawm cov tshuaj Mikstard 30 NM Penfill yog txiav txim los ntawm tus kws kho mob tshwj xeeb hauv txhua kis. Cov tshuaj yog muab tshuaj subcutaneously. Tom qab txhaj koob, rab koob yuav tsum nyob twj ywm hauv qab ntawm daim tawv nqaij li rau rau 6 feeb, uas ua kom muaj kev tiv thaiv puv nkaus.

Thaum hloov mus rau tus neeg mob los ntawm cov roj ntshiab heev los yog tib neeg cov tshuaj insulin rau Mikstard 30 NM Penfill, cov koob tshuaj ntawm cov tshuaj tseem zoo li qub.

Thaum hloov cov neeg mob los ntawm nqaij nyug lossis cov tshuaj insulin sib xyaw rau Mikstard 30 NM Penfill, cov koob tshuaj insulin feem ntau txo 10%, tshwj tsis yog thaum pib koob yog tsawg dua 0.6 U / kg ntawm lub cev qhov hnyav.

Ntawm qhov kev noj tshuaj txhua hnub dhau ntawm 0.6 PIECES / kg ntawm lub cev qhov hnyav, insulin yuav tsum tau txhaj 2 koob tshuaj hauv qhov chaw sib txawv.

Cov kev cai tswj kev siv tus cwj mem Penfill thiab cov kev tswj hwm tshuaj

Ua ntej siv, nco ntsoov tias tsis muaj kev puas tsuaj rau lub Penfill cartridge. Penfill tsis siv yog tias muaj qhov pom pom kev puas tsuaj lossis yog qhov dav ntawm qhov pom ntawm cov roj hmab piston loj dua qhov dav ntawm cov kab txaij dawb. Ua ntej yuav ntxig tus cwj mem Penfill rau hauv daim ntaub qhwv lub tes tsho, nws yuav tsum tau co thiab tsej. Kev txav yuav tsum ua kom lub khob pob hauv qhov laub txav ntawm ib qho mus rau lwm qhov. Qhov kev tswj hwm no yuav tsum tau rov ua dua tsawg kawg 10 zaug - kom txog thaum cov kua ua huab li huab thiab dawb. Yog tias Penfill daim cartridge twb tau ntxig rau hauv tus xaum xaum, rov ua qhov txheej txheem sib xyaw ua ntej txhua qhov kev txhaj tshuaj tom ntej. Tom qab txhaj, koob yuav tsum nyob twj ywm hauv qab daim tawv nqaij tsawg kawg 6 vib nas this. Lub tes tsho xuas tes xoos yuav tsum tau nias cia kom txog thaum rab koob raug tshem tawm hauv qab ntawm daim tawv nqaij. Tom qab txhaj txhua, koob yuav tsum tau muab tshem tawm sai li sai tau.

Penfill yog rau kev siv tus kheej nkaus xwb.

Tus cwj mem Penfill tuaj yeem siv cov tshuaj NovoPen 3, Innovo koob txhaj tshuaj lossis nqa nrog koj kom ntev li 1 lub hlis.

Thaum twg daim cartridge tau tso rau hauv NovoPen 3 koob txhaj tshuaj, ib txoj hlua xim yuav tsum pom ntawm lub qhov rai ntawm tus tuav lub taub.

Tej yam tsis zoo

Kev phiv los cuam tshuam nrog cov ntxim rau cov metabolism carbohydrate: hypoglycemic tej yam kev mob (pallor, nce tawm hws, palpitations, pw tsaug zog tsis meej, tshee).

Kev tsis haum tshuaj: tsis tshua muaj - tawv nqaij ua pob, tsis tshua muaj mob - mob caj dab.

Cov tshuaj tiv thaiv hauv zos: tsis tshua muaj - hyperemia thiab khaus ntawm qhov chaw txhaj tshuaj ntawm cov tshuaj, nrog siv ntev heev tsis tshua muaj - lipodystrophy ntawm qhov chaw txhaj tshuaj.

TSWJ SIB LWM

TEJ YEEM THIAB LUS

Thaum cev xeeb tub thiab lactation, tus neeg mob xav tau cov tshuaj insulin hloov, uas yuav tsum tau muab coj los tswj kom muaj kev tswj lub cev kom txaus.

Cov tshuaj Insulin tsis hla qhov chaw tiv thaiv.

Thaum siv cov tshuaj Mikstard 30 NM Penfill thaum lactation, tsis muaj kev pheej hmoo rau tus menyuam.

COV LUS QHIA TSHWJ XEEB

Cov neeg mob uas tau txais ntau dua 100 IU ntawm cov tshuaj insulin ib hnub yuav tsum tau mus pw hauv tsev kho mob thaum hloov cov tshuaj.

Kev hloov pauv ntawm ib hom tshuaj insulin mus rau lwm qhov yuav tsum tau ua nyob ntawm kev tswjhwm ntawm cov ntshav nyob rau qib.

Nyob rau hauv kev cuam tshuam ntawm insulin, kam rau ua cawv kom tsawg.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tom qab tus neeg mob hloov mus rau biosynthetic tib neeg cov tshuaj insulin, lub peev xwm tsav tsheb thiab koom nrog lwm yam kev muaj feem phom sij uas xav tau kev nce siab ntxiv thiab ceev ntawm psychomotor cov kev cuam tshuam yuav mus ib ntus.

OVERDOSE

Cov tsos mob cov tsos mob thawj zaug ntawm kev mob ntshav qab zib - nce ntau hws, tshee, tshee tshee, tshaib plab, ntxhov siab, kab mob hauv lub qhov ncauj, pallor, mob taub hau, pw ntxhov. Nyob rau hauv loj mob ntawm overdose - coma.

Kev Kho Mob: tus neeg mob tuaj yeem tshem tawm qhov mob ntshav qab zib me me los ntawm kev noj zaub mov qab zib lossis cov zaub mov muaj suab thaj. Hauv cov xwm txheej loj, subcutaneous lossis intramuscularly muab 1 mg ntawm glucagon. Yog tias tsim nyog, kev kho mob txuas ntxiv iv nrog kev qhia txog kev siv tshuaj dextrose daws teeb meem.

KEV TXHAWB

Cov nyhuv hauv kev ua haujlwm ntawm insulin yog txhim kho los ntawm MAO inhibitors, tsis-xaiv beta-blockers, sulfonamides, anabolic steroids, tetracyclines, clofibrate, cyclophosphamide, fenfluramine, thiab cov kev npaj muaj ethanol.

Cov tshuaj tiv thaiv tsis haum, glucocorticoids, cov thyroid hormones, thiazide diuretics, heparin, lithium npaj, tricyclic antidepressants txo cov nyhuv hypoglycemic ntawm insulin.

Hauv qab ntawm reserpine thiab salicylates, ob qho tib si qaug zog thiab txhim kho kev ua ntawm insulin yog ua tau.

Ethanol, ntau yam tshuaj tua kab mob tuaj yeem txo qhov kev lom neeg lom neeg ntawm insulin.

PHARMACY HOLIDAY KEV PAB CUAM

Cov tshuaj yog ntawv yuav tshuaj.

COV LUS QHIA THIAB KEV HNUB NYOOG NTAWM Kev KHWV

Mem hluav roj cartridge yuav tsum muab ntim rau hauv ib pob, hauv qhov chaw tiv thaiv los ntawm tshav ntuj ntawm qhov kub ntawm 2 ° txog 8 ° C, tsis txhob khov. Kev siv tus cartridge Penfill tsis pom zoo kom muab cia rau hauv lub tub yees.

Mazovetsky A.G., Velikov V.K. Mob ntshav qab zib mellitus, Tshuaj -, 1987. - 288 p.
Tsonchev Laboratory kuaj mob rheumatic kab mob / Tsonchev, lwm yam V. thiab. - M.: Sofia, 1989 .-- 292 p.
Daeidenkoea E.F., Liberman I.S. Noob caj noob ces mob ntshav qab zib. Leningrad, tshaj tawm tsev "Tshuaj", 1988, 159 pp.

Cia kuv qhia kuv tus kheej. Kuv lub npe yog Elena. Kuv tau ua haujlwm li endocrinologist rau ntau tshaj 10 xyoo. Kuv ntseeg hais tias tam sim no kuv yog tus kws tshaj lij hauv kuv daim teb thiab kuv xav pab txhua tus neeg tuaj saib lub vev xaib kom daws qhov nyuaj thiab tsis yog li cov haujlwm. Txhua cov ntaub ntawv rau lub xaib tau sau thiab ua tib zoo ua kom tiav thiaj li xa ntau li ntau tau cov ntaub ntawv tsim nyog. Ua ntej thov cov ntaub ntawv uas tau piav qhia hauv lub vev xaib, yuav tsum tau sab laj nrog tus kws kho mob tshwj xeeb.

Cov lus qhia rau kev siv tshuaj

Ua ntej ua cov kev kho insulin, ntau txoj cai yuav tsum paub:

Kev raug txwv tsis pub muab cov tshuaj rau hauv lub cev.
Kev txhaj tshuaj subcutaneous tau ua nyob hauv anterior plab phab ntsa, ncej puab, thiab qee zaum hauv deltoid cov leeg ntawm lub xub pwg lossis pob tw.
Ua ntej cov lus qhia, nws raug nquahu kom ncua daim tawv nqaij, uas yuav txo qhov ntau ntawm qhov sib xyaw kom tau mus rau hauv cov leeg.
Koj yuav tsum paub tias nrog s / c txhaj tshuaj ntawm cov tshuaj insulin rau hauv plab phab ntsa, nws txoj kev nqus tau tshwm sim sai dua nrog kev qhia ntawm cov tshuaj mus rau lwm thaj chaw ntawm lub cev.
Txhawm rau tiv thaiv kev txhim kho ntawm lipodystrophy, qhov chaw txhaj tshuaj yuav tsum tau hloov tas li.

Nws tsim nyog sau cia tias cov hwj muaj cov kaus mom tiv thaiv yas uas tau muab tshem tawm ua ntej cov tshuaj insulin.

Txawm li cas los xij, ua ntej nws tsim nyog xyuas seb lub hau npog nruj npaum li cas rau lub hwj, thiab yog tias nws ploj lawm, ces cov tshuaj yuav tsum tau rov qab mus rau lub tsev muag tshuaj.

Mikstard 30 Flexpen: cov lus qhia rau kev siv

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov ntshav qab zib feem ntau nqis los rau qhov tseeb tias nws yooj yim tshaj plaws los siv Mixtard 30 FlexPen.

Qhov no yog ib qho tshuaj insulin syringe cwj mem nrog cov koob tshuaj xaiv, nrog uas koj tuaj yeem teeb qhov ntau npaum li ntawm 1 txog 60 units hauv qhov nce ntawm ib chav.

Tom qab ntawd, koj yuav tsum tau ua cov theem nram qab no:

Cov roj hmab nyias kho tau nrog cawv.
Daim paib kev nyab xeeb raug tshem tawm ntawm rab koob.
Lub koob txhaj kiav txhab ntawm Flexpen.
Huab cua yog tshem tawm los ntawm daim cartridge.

Ua ntej, cov koob xaiv xaiv tau muab teem rau xoom, thiab tom qab ntawd cov koob tshuaj xav tau yog teeb tsa. Yog tias cov xaiv tau tig los txo cov koob tshuaj, nws yog qhov yuav tsum tau saib xyuas lub pob pib, vim tias yog nws tau chwv, ces qhov no tuaj yeem ua rau cov tshuaj insulin to.

Yog li, rau txhua qhov txhaj tshuaj, koj yuav tsum siv rab koob tshiab. Tom qab txhua qhov, thaum qhov kub hloov pauv, insulin tsis tuaj yeem los ntawm.

Nws yog qhov tsim nyog tias FdeksPen tsis tuaj yeem rov ua tiav. Ua ntu zus, cov chaw uas txhaj tshuaj yuav tsum ntxuav.Rau lub hom phiaj no, nws yog wiped nrog paj rwb ntaub plaub soaked nyob rau hauv cawv.

Txawm li cas los xij, tsis txhob ntub, ntxhua, los yog nqus cov cuab yeej hauv ethanol. Tom qab tag nrho, qhov no tuaj yeem ua kev puas tsuaj rau cov koob txhaj tshuaj.

Kev sib cuam tshuam nrog lwm yam tshuaj thiab lwm yam kev sib cuam tshuam

Raws li koj paub, ntau ntawm cov tshuaj cuam tshuam rau cov metabolism hauv cov piam thaj.

Cov tshuaj uas yuav txo qhov xav tau insulin

Cov tshuaj tiv thaiv kab mob rau lub cev (PSS), monoamine oxidase inhibitors (MAOs), tsis muaj kev xaiv b-blockers, ACE inhibitors (ACE), salicylates, anabolic steroids thiab sulfonamides.

Cov tshuaj uas tuaj yeem xav tau cov insulin ntau ntxiv

Cov tshuaj tiv thaiv hauv qhov ncauj, thiazides, glucocorticoids, cov thyroid hormones, sympathomimetics, kev loj hlob hormone thiab danazole.

adrenergic blockers tuaj yeem npog cov tsos mob ntawm kev mob qog ntshav qab zib thiab kev ua kom rov qab sai sai tom qab muaj ntshav qog ntshav qab zib.

Octreotide / lanreotide ob leeg tuaj yeem txo qis thiab nce qhov kev xav tau rau insulin.

Cawv yuav ua kom cov ntshav qis los tsis txaus.

Daim ntawv thov nta

Noj tshuaj kom tsis txaus los sis tsis txuas kev kho mob (tshwj xeeb tshaj yog muaj ntshav qab zib hom I) tuaj yeem ua rau hyperglycemia thiab ntshav ketoacidosis. Feem ntau, thawj cov tsos mob ntawm hyperglycemia pib maj mam dhau ob peb teev lossis hnub. Cov no suav nrog kev nqhis dej, tso zis tsis tu ncua, xeev ntuav, ntuav, nkees, liab thiab daj ntawm daim tawv nqaij, qhov ncauj qhuav, tsis qab los noj mov, thiab tsis hnov ntxhiab ntawm cov acetone hauv cov pa tawm.

Hauv cov ntshav qab zib hom I, hyperglycemia, uas tsis kho, ua rau ketoacidosis uas mob ntshav qab zib, uas ua rau muaj kev tuag taus.

Kev ntshav siab tej zaum yuav tshwm sim yog tias cov koob tshuaj insulin ntau dhau rau hauv qhov xav tau ntawm cov tshuaj insulin. Yog tias cov ntshav qog ntshav qab zib lossis yog tias xav tias hypoglycemia tsis zoo, tsis txhob tswj cov tshuaj.

Noj zaub mov tsis zoo lossis ua kom lub cev tsis muaj zog ua rau lub cev ntuag ntshav qab zib.

Cov neeg mob uas tau txais kev tswjhwm zoo tshaj plaws ntawm cov ntshav qabzib ntau vim kev siv tshuaj insulin ntau ntxiv tuaj yeem pom qhov txawv txav hauv lawv cov tsos mob ib txwm muaj, kev tawm tsam sai ntawm hypoglycemia, uas yuav tsum ceeb toom ua ntej.

Cov paib ceeb toom ib txwm yuav ploj hauv cov neeg mob uas mob ntshav qab zib ntev.

Kev sib txuam, tshwj xeeb tshaj yog kis thiab fevers, nce qhov kev xav tau ntawm insulin. Cov kab mob uas tsis haum rau ob lub raum, mob siab, lub qog, lub qog ua rau lub qog, cov qog ua rau cov thyroid caj pas yuav ua rau muaj kev hloov pauv ntawm cov tshuaj insulin. Thaum tus neeg mob hloov mus rau lwm hom tshuaj insulin, cov tsos mob ntawm lub qog ntshav qab zib yuav hloov lossis ua kom nrov meej.

Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis hom insulin tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj. Kev hloov pauv ntawm cov kev xav, hom (chaw tsim khoom), hom, keeb kwm ntawm insulin (tib neeg lossis kev sib piv ntawm tib neeg cov insulin) thiab / lossis cov txheej txheem ntau lawm yuav tsum tau tsim kho cov tshuaj insulin. Cov neeg mob uas tau hloov mus rau Mikstard ® 30 NM uas muaj qhov sib txawv ntawm insulin tuaj yeem xav tau qhov nce ntxiv ntawm kev txhaj tshuaj txhua hnub lossis hloov pauv hauv qhov ntau dua piv rau cov tshuaj insulin uas lawv ib txwm siv. Qhov kev xav tau ntawm kev xaiv koob tshuaj yuav tshwm sim ob qho tib si hauv thawj zaug kev siv tshuaj tshiab, thiab nyob rau thawj ob peb lub lis piam lossis lub hlis ntawm kev siv.

Thaum siv cov tshuaj insulin, cov tshuaj tiv thaiv tuaj yeem tshwm sim ntawm qhov chaw txhaj tshuaj, uas yuav suav nrog qhov mob, liab liab, khaus, ua xua, o, o tuaj thiab o.

Insulin kev ncua yuav tsum tsis txhob siv cov tshuaj insulin twj rau lub caij nyoog ua haujlwm ntev ntawm kev siv tshuaj insulin.

Kev sib xyaw ntawm thiazolidinediones thiab cov tshuaj insulin

Thaum thiazolidinediones siv nrog kev siv tshuaj insulin, cov mob ntawm lub plawv tsis ua haujlwm tau tshaj tawm, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kev pheej hmoo rau txoj kev tsis ua haujlwm txhawm rau lub siab. Qhov no yuav tsum tau txiav txim siab thaum sau ntawv kho mob nrog kev sib xyaw ntawm thiazolidinediones nrog insulin. Nrog rau kev siv cov tshuaj no ua ke, cov neeg mob yuav tsum tau saib xyuas los ntawm kws kho mob rau kev txhim kho cov cim thiab cov tsos mob ntawm lub plawv tsis ua haujlwm, hnyav ntxiv thiab tshwm sim ntawm edema. Yog tias lub cev tsis ua hauj lwm hauv lub plawv, kho nrog thiazolidinediones yuav tsum tsis ua mus ntxiv.

Cov neeg laus (> 65 xyoo).

Cov tshuaj Mikstard® 30 NM tuaj yeem siv rau cov neeg laus laus.

Hauv cov neeg laus cov neeg mob, yuav tsum saib xyuas cov piam thaj thiab cov koob tshuaj insulin hloov kho ib tus zuj zus.

Plaws thiab lub siab ua haujlwm.

Cov hlwv thiab hepatic tsis txaus tuaj yeem txo qhov xav tau ntawm insulin. Hauv cov neeg mob uas lub raum thiab hepatic tsis txaus, kev saib xyuas ntshav qabzib yuav tsum muaj zog thiab qhov koob tshuaj insulin kho tus kheej.

Siv thaum cev xeeb tub lossis lactation .

Vim tias cov tshuaj insulin hla tsis dhau qhov tsis haum, tsis muaj kev txwv rau kev kho mob ntshav qab zib nrog insulin thaum cev xeeb tub.

Qhov kev xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntxiv hauv zaum ob thiab thib ob

Tom qab yug los, xav tau cov tshuaj insulin sai sai rov qab rau hauv paus.

Kuj tseem tsis muaj kev txwv rau kev kho mob ntshav qab zib nrog insulin thaum pub niam mis, txij li kev kho leej niam tsis ua rau muaj kev pheej hmoo rau tus menyuam. Txawm li cas los xij, nws yuav tsim nyog kho qhov tshuaj thiab / lossis noj zaub mov kom zoo rau leej niam.

Tsiaj tshawb xyuas kev muaj me nyuam muaj mob toxicity siv tib neeg lub cev

tsis tau piav qhia txog qhov ua tsis zoo rau kev ua tub rog.

Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem.

Tus neeg mob cov lus teb thiab nws lub peev xwm los mloog zoo yuav ua rau lub plawv tsis muaj ntshav qab zib.

Qhov no tuaj yeem dhau los ua kev pheej hmoo rau hauv cov xwm txheej uas qhov peev xwm no yog qhov tseem ceeb tshwj xeeb (piv txwv, thaum tsav tsheb tsheb lossis tshuab).

Cov neeg mob yuav tsum qhia rau lawv kom ntsuas los tiv thaiv kom tsis txhob muaj ntshav qab zib ua ntej tsav tsheb. Qhov no yog qhov tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj zog lossis tsis muaj cov tsos mob tshwm sim ua ntej ntawm lub qog ntshav ntshav lossis lub sijhawm ntog ntshav siab tsis tshua tshwm sim ntau zaus. Thaum muaj teeb meem li no, qhov tsim nyog ntawm kev tsav tsheb yuav tsum ntsuas.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

1 ml ntawm kev ncua rau kev txhaj tshuaj muaj tib neeg biosynthetic insulin 100 IU (solulin insulin 30% thiab isofan-insulin raug tshem tawm 70%), hauv 3 ml Penfill cartridges rau kev siv nrog NovoFen 3 insulin koob txhaj tshuaj thiab NovoFine koob thiab hauv 1.5 ml Penfill cartridges rau kev siv hauv NovoPen lossis NovoPen II koob txhaj tshuaj, hauv ib lub hlwv ntim ntawm 5 pcs. lossis hauv lub hwj ntawm 10 ml.

Kev phiv tshuaj

Ib qho kev phiv rau txoj kev kho yog hypoglycemia. Raws li kev tshawb fawb soj ntsuam, nrog rau cov ntaub ntawv hais txog kev siv tshuaj tom qab nws tso tawm ntawm lub lag luam, qhov kev pheej hmoo ntawm hypoglycemia sib txawv ntawm cov pab pawg sib txawv ntawm cov neeg mob, nrog ntau cov tshuaj sib txawv thiab qib glycemic tswj (saib. Cov ntaub ntawv hauv qab).

Thaum pib ntawm cov tshuaj insulin, kev ua kom tsis raug, kev txhawm thiab tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj (mob, liab, urticaria, o, doog, o thiab khaus ntawm qhov chaw txhaj tshuaj) tuaj yeem pom. Cov kev tsis haum no feem ntau yog ua dhau. Kev txhim kho sai ntawm cov ntshav qabzib tswj ntshav tuaj yeem ua rau lub xeev rov qab ua haujlwm ntawm qhov mob siab neuropathy.

Kev txhim kho ntse hauv glycemic tswj vim tias kev siv tshuaj insulin ntau ntxiv tuaj yeem nrog lub sij hawm exacerbation ntawm cov ntshav qab zib retinopathy, thaum lub sijhawm ntev tsim tau glycemic tswj txo qhov kev pheej hmoo ntawm kev mob ntshav qab zib retinopathy.

Raws li kev tshawb fawb hauv chav kho mob, cov hauv qab no yog cov kev phiv tshuaj uas yog cais raws zaus thiab kab ke hauv chav kawm raws li MedDRA.

Raws li qhov muaj ntau zaus tshwm sim, cov kev tawm tsam no tau muab faib ua cov uas muaj ntau zaus (/1 / 10), feem ntau (≥1 / 100 txog 1/1000 txog 1/10000 txog ® 30 NM yuav tsum muab cia rau hauv tub yees ntawm qhov kub ntawm 2 - 8 ° C (tsis yog kom nyob ze rau lub tub yees txias). Tsis khov.

Khaws lub hnab ntim khoom cia kom ncav cuag cov menyuam yaus ncav cuag.

Txav deb ntawm qhov kub lossis qhov tshav ncaj.

Txhua lub raj mis muaj qhov tiv thaiv, xim xim ntawm yas. Yog tias cov hau yas tiv thaiv tsis haum snugly lossis ploj lawm, lub raj mis yuav tsum rov qab mus rau lub tsev muag tshuaj.

Cov vials Mikstard ® 30 NM uas tau siv yuav tsum tsis txhob muab tso rau hauv lub tub yees. Lawv tuaj yeem muab cia rau hauv chav tsev kub (tsis siab tshaj 25 ° C) rau 6 lub lis piam tom qab qhib lossis rau 5 lub lim tiam ntawm qhov kub tsis tshaj 30 ° C.

Kev siv tshuaj insulin uas tau ua kom khov yuav tsum tsis txhob siv.

Tsis txhob siv cov tshuaj insulin tom qab hnub tas sij hawm luam tawm ntawm lub pob.

Mikstard® 30 NM yuav tsum tsis txhob siv yog tias, tom qab sib xyaw cov ntsiab lus ntawm lub vial, cov kua tsis tig dawb thiab sib npaug zos ntawm huab.

Pharmacological kev txiav txim

Nws cuam tshuam nrog ib qho plasma membrane receptor thiab nkag mus rau hauv lub cell, qhov chaw nws ua kom lub phosphorylation ntawm cov xovtooj ntawm cev, ua rau lub cev glycogen synthetase, pyruvate dehydrogenase, hexokinase, inhibits adipose nqaij lipase thiab lipoprotein lipase. Ua ke nrog ib qho tshwj xeeb receptor, nws yooj yim nkag mus ntawm kev nqus ntawm cov kua nplaum mus rau hauv cov hlwb, txhim kho nws txoj kev nkag los ntawm cov ntaub so ntswg thiab txhawb kev hloov dua siab tshiab rau glycogen. Ua rau cov nqaij glycogen ntau ntxiv, txhawb kev ua kom peptide hluavtaws.

Kev tiv thaiv kev nyab xeeb

Tus Penfill cartridge yog rau kev siv tus kheej nkaus xwb. Tom qab txhaj tshuaj rau qhov tsawg kawg yog 6 s, koob yuav tsum nyob twj ywm hauv qab daim tawv nqaij kom txhaj tag nrho. Nws yuav tsum tau yug los hauv lub siab tias lub peev xwm los tsav lub tsheb tom qab hloov cov neeg mob mus rau tib neeg cov kua dej yuav txo qis ib ntus. Koj yuav tsum tsis txhob siv cov tshuaj yog hais tias nrog nplawm qhov kev ncua tsis txhob ua homogeneous.