Insulin Glargin: nta thiab txoj kev ntawm daim ntawv thov

Kev noj zaub mov zoo, kev tawm dag zog thiab ua raws li lwm cov lus qhia ntawm cov kws kho mob tsis ib txwm muab cov txiaj ntsig kev cia siab. Yog li, cov neeg mob ntshav qab zib feem ntau tau hloov cov tshuaj insulin. Ib ntawm lawv yog Insulin Glargin. Qhov no yog ib qho piv txwv ntawm cov roj ntsha ntuj tsim los ntawm tib neeg lub cev. Dab tsi yog cov yam ntxwv ntawm kev siv tshuaj?

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm kev daws rau subcutaneous (s / c) kev tswj hwm: cov kua ntshiab, tsis muaj kob (3 ml txhua hauv iav pob tshab pob tshab tsis muaj xim, 1 lossis 5 pob hauv daim duab hauv cov hlwv pob, 1 ntim hauv ib pob ntawv, 10 ml hauv pob tshab fwj tsis muaj xim, hauv daim duab thawv 1 lub fwj thiab cov lus qhia rau kev siv tshuaj Insulin glargin).

1 ml ntawm cov tshuaj muaj:

cov tshuaj nquag: insulin glargine - 100 PIECES (chav ua haujlwm ntawm kev ua), uas yog sib npaug rau 3.64 mg,
Cov khoom siv pabcuam: zinc chloride, metacresol, glycerol, sodium hydroxide, hydrochloric acid, dej rau kev txhaj tshuaj.

Cov Tshuaj Hauv Tshuaj

Insulin glargine yog tshuaj hypoglycemic, ib qho piv ntawm cov tshuaj insulin ntev ntev.

Cov tshuaj tseem ceeb ntawm cov tshuaj yog insulin glargine, ib qho piv txwv ntawm tib neeg cov tshuaj insulin tau los ntawm kev rov ua kom tiav ntawm DNA (deoxyribonucleic acid) hom kab mob K12 kab mob ntawm hom Escherichia coli.

Insulin glargine yog tus cwj pwm los ntawm qis qis solubility hauv ib puag ncig nruab nrab. Kev ua tiav solubility ntawm cov tshuaj nquag hauv sib xyaw ua ke ntawm cov tshuaj tau tiav vim muaj cov ntsiab lus ntawm hydrochloric acid thiab sodium hydroxide. Lawv cov nyiaj tau muab kev daws nrog ib qho tshuaj tiv thaiv acid - pH (acidity) 4, uas, tom qab cov tshuaj tau qhia rau hauv cov rog subcutaneous, yog neutralized. Raws li qhov tshwm sim, microprecipitate yog tsim, los ntawm qhov uas muaj ib qho kev tso tawm tas li ntawm cov tshuaj insulin glargine me me, uas muab cov tshuaj nrog cov kev ua haujlwm ntev thiab ib daim ntawv ncaj ncees kom paub meej txog qhov xav txog lub sijhawm nkhaus.

Lub zog sib txuas ntawm kev khi ntawm insulin glargine thiab nws cov nquag metabolites M1 thiab M2 rau cov insulin tshwj xeeb yog ze rau cov tib neeg ntawm insulin, uas txiav txim siab lub peev xwm ntawm insulin glargine kom muaj kev lom roj ntsha zoo ib yam li insulin endogenous.

Kev ua tseem ceeb ntawm insulin glargine yog kev cai ntawm cov metabolism hauv cov piam thaj. Los ntawm inhibiting cov synthesis ntawm qabzib nyob rau hauv daim siab thiab txhawb kev nqus ntawm cov kua nplaum los ntawm cov ntaub so ntswg adipose, cov leeg pob txha thiab lwm cov ntaub so ntswg, nws pab txo cov kev xav ntawm cov piam thaj hauv cov ntshav. Txhawb nqa lipolysis hauv adipocytes thiab qeeb lub cev proteolysis, thaum nce kev tsim cov protein.

Lub caij nyoog ntev ua ntawm insulin glargine yog vim muaj qhov txo qis ntawm nws txoj kev nqus. Qhov nruab nrab lub sijhawm ntawm cov tshuaj insulin glargine tom qab kev tswj hwm subcutaneous yog 24 teev, qhov siab tshaj yog 29 teev. Cov nyhuv ntawm cov tshuaj tshwm sim kwv yees li 1 teev tom qab kev tswj hwm. Nws yuav tsum tau yug hauv siab tias lub sijhawm ntawm kev ua ntawm insulin glargine hauv cov neeg mob sib txawv lossis hauv ib tus neeg mob tuaj yeem sib txawv.

Qhov ua tau zoo ntawm cov tshuaj hauv cov menyuam yaus uas muaj hom 1 mob ntshav qab zib mellitus hnub nyoog 2 xyoos tau raug lees paub. Thaum siv cov tshuaj insulin glargine, muaj ib qho kev tshwm sim qis dua los ntawm kev saib xyuas cov ntshav qog ntshav qab zib thaum nruab hnub thiab hmo ntuj hauv cov menyuam yaus hnub nyoog 2-6 xyoo piv nrog insulin-isofan.

Cov txiaj ntsig ntawm kev kawm ntev txog 5 xyoo qhia tau hais tias nyob hauv cov neeg mob uas muaj ntshav qab zib hom 2 ntshav qab zib, kev siv cov tshuaj insulin glargine lossis insulin-isophan muaj tib lub txiaj ntsig rau kev loj hlob ntawm tus mob ntshav qab zib retinopathy.

Piv rau tib neeg cov tshuaj insulin, qhov sib raug zoo ntawm insulin glargine rau IGF-1 receptor (insulin-zoo li qhov kev loj hlob insulin 1) yog kwv yees li 5-8 zaug siab dua, thiab cov nquag metabolites M1 thiab M2 yog me dua.

Hauv cov neeg mob uas muaj hom 1 mob ntshav qab zib mellitus, tag nrho qhov kev xav ntawm insulin glargine thiab nws cov metabolites yog qis dua qib uas yuav tsum tau ua rau ib nrab-qhov siab tshaj plaws rau IGF-1 receptors, tom qab ntawd ua kom muaj kev tiv thaiv ntawm txoj kev ua kom cov kab mob ua kom tsis muaj kab mob, uas ua rau ntawm IGF-1 receptors. Nyob rau hauv kev sib piv rau lub zog ntau ntawm endogenous IGF-1, kev kho tshuaj insulin qhov ua tiav nrog kev kho cov tshuaj insulin yog qhov qis dua qhov kev tso tshuaj ntawm lub zog txaus ua kom muaj lub zog ntawm txoj kev loj hlob.

Cov txiaj ntsig ntawm kev tshawb nrhiav pom tau hais tias thaum siv cov tshuaj insulin glargine rau cov neeg mob uas muaj kev pheej hmoo loj ntawm kev mob plawv thiab tsis muaj peev xwm ua rau cov ntshav qabzib tsis txaus, muaj kev yoo mov lossis cov ntshav qab zib thaum ntxov hom 2, qhov zoo li ntawm kev txhim kho plawv lossis lub plawv kev tuag yog qhov sib piv. nrog cov ntawm cov txheej txheem kho hypoglycemic. Tsis muaj qhov sib txawv hauv cov nqi ntawm ib feem twg siv tawm ntawm cov ntsiab lus xaus, cov ntsuas sib xyaw ua ke ntawm cov txiaj ntsig microvascular, thiab kev tuag ntawm txhua qhov ua rau.

Cov Tshuaj Pharmacokinetics

Piv nrog cov tshuaj insulin-isophan, tom qab kev coj noj coj ua ntawm cov tshuaj insulin glargine, kev qeeb qeeb thiab kev nqus ntev yog pom, thiab tsis muaj lub ncov siab nyob rau hauv kev siab.

Tawm tsam cov keeb kwm yav dhau los ntawm ib qho kev niaj hnub subcutaneous tswj hwm ntawm Insulin glargine, qhov sib npaug ntawm cov tshuaj nquag hauv cov ntshav tau mus txog tom qab 2-4 hnub.

Ib nrab-lub neej (T_1/2a) insulin glargine tom qab kev tswj hwm zoo piv rau T_1/2 tib neeg cov insulin.

Thaum cov tshuaj tau txhaj rau hauv lub plab, ncej puab, lossis xub pwg, tsis muaj qhov sib txawv hauv cov ntshav insulin ntau.

Cov tshuaj insulin glargine yog qhov txawv txav qis dua ntawm cov profile pharmacokinetic nyob hauv tib tus neeg mob lossis hauv cov neeg mob sib txawv piv rau nruab nrab ntawm tib neeg cov tshuaj insulin.

Tom qab cov tshuaj insulin glargine nkag tau rau hauv cov roj ntsha subcutaneous, ib feem ntawm kev sib xyaw the-cov saw (beta-saw) los ntawm cov carboxyl kawg (C-terminus) tshwm sim nrog kev tsim ntawm ob lub cev nquag: M1 (21 A -Gly-insulin) thiab M2 (21 A - Gly-des-30 B-Thr-insulin). Cov tshuaj metabolite M1 nthuav dav nyob rau hauv cov ntshav ntshav, nws cov kev kis kab mob hauv lub cev nce ntxiv nrog cov tshuaj ntau ntxiv. Qhov kev txiav txim ntawm insulin glargine yog pom tseeb vim tias muaj kev cuam tshuam txhua yam ntawm cov metabolite M1. Feem ntau ntawm feem ntau ntawm cov neeg mob, insulin glargine thiab metabolite M2 tsis tuaj yeem pom nyob rau hauv cov kab ke ntsig. Hauv qee qhov xwm txheej tsawg kawg ntawm kev tshawb pom ntawm insulin glargine thiab M2 metabolite hauv cov ntshav, cov concentration ntawm lawv tsis cia siab rau kev siv tshuaj ntawm cov tshuaj.

Cov nyhuv ntawm tus neeg mob lub hnub nyoog thiab poj niam txiv neej ua ke ntawm pharmacokinetics ntawm insulin glargine tsis tau tsim.

Kev ntsuam xyuas cov txiaj ntsig ntawm kev soj ntsuam hauv chav kawm los ntawm pab pawg sib txawv qhia txog qhov tsis muaj qhov sib txawv ntawm kev nyab xeeb thiab ua tau zoo ntawm insulin glargine rau cov neeg haus luam yeeb piv nrog cov pej xeem.

Hauv cov neeg mob rog rog, kev nyab xeeb thiab siv tau ntawm cov tshuaj tsis yog kev cuam tshuam.

Cov tshuaj pharmacokinetics ntawm insulin glargine rau cov menyuam yaus hnub nyoog 2 txog 6 xyoo uas muaj ntshav qab zib hom 1 zoo ib yam li cov laus.

Nrog rau qhov kev ua rau daim siab hnyav, lub biotransformation ntawm insulin hloov qis vim tias qhov qis qis ntawm lub peev xwm ua rau daim siab ua rau gluconeogenesis.

Cov Yuav Tsum Muaj

hnub nyoog txog li 2 xyoos
ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Nrog kev ceev faj, insulin glargine yuav tsum raug siv rau hauv cov neeg mob uas muaj kev loj hlob ntawm cov hlab ntsha hlwb, mob ntshav khov ntawm cov hlab ntsha hauv hlab ntshav lossis hlab hlwb, thaum cev xeeb tub thiab pub niam mis.

Glulin insulin, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Kev siv tshuaj insulin glargine yuav tsum tsis txhob muab tshuaj rau (iv)!

Kev daws yog npaj rau sc tswj hwm hauv subcutaneous rog ntawm lub plab, ncej puab lossis lub xub pwg. Qhov chaw txhaj tshuaj yuav tsum tau hloov mus rau hauv ib qho ntawm cov chaw pom zoo.

Tsis muaj kev rov ua dua ntawm cov tshuaj ua ntej siv yuav tsum tau ua.

Yog tias tsim nyog, insulin glargine tuaj yeem tshem tawm ntawm daim cartridge mus rau hauv cov koob txhaj tshuaj kom tsis haum rau cov tshuaj insulin thiab cov koob xav tau tuaj yeem raug tswj hwm.

Cartridges tuaj yeem siv nrog endo-mem koob txhaj tshuaj.

Cov tshuaj yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulins!

Cov koob tshuaj, lub sijhawm ntawm kev tswj hwm ntawm cov tshuaj hypoglycemic thiab lub hom phiaj muaj txiaj ntsig ntawm kev saib xyuas cov piam thaj hauv cov ntshav tau txiav txim siab thiab kho tus kheej los ntawm tus kws kho mob.

Cov txiaj ntsig ntawm kev hloov pauv hauv tus neeg mob lub cev, suav nrog kev ua haujlwm ntawm lub cev, ntawm qhov nruab nrab ntawm kev nqus, pib thiab lub sijhawm ua haujlwm ntawm cov tshuaj yuav tsum raug txiav txim siab.

Cov tshuaj insulin glargine yuav tsum muab s / c 1 zaug nyob rau ib hnub ib txwm tib lub sijhawm, yooj yim rau tus neeg mob.

Txhua tus neeg mob ntshav qab zib yuav tsum muaj kev soj ntsuam cov ntshav qabzib ntau.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, insulin glargine tuaj yeem siv los ua kev kho mob thiab ua kom sib xyaw nrog lwm tus neeg mob ntshav qab zib.

Kev kho ntawm cov koob tshuaj tiv thaiv kab mob yuav tsum tau ua nrog ceev faj thiab nyob rau hauv kev saib xyuas mob. Ib qho kev hloov pauv hauv lub cev yuav tsum yog tus neeg mob lub cev qhov hnyav los txo lossis nce, lub sijhawm ntawm kev siv tshuaj, nws txoj kev ua neej thiab lwm yam kev mob nce ntxiv qhov kev cuam tshuam rau kev txhim kho hyper- lossis hypoglycemia.

Insulin glargine tsis yog cov tshuaj ntawm kev xaiv rau mob ntshav qab zib ketoacidosis, kev kho mob uas cuam tshuam nrog kev qhia ntawm luv luv ua yeeb yam insulin.

Yog tias cov tshuaj kho mob suav nrog kev txhaj tshuaj insal basal thiab prandial insulin, tom qab ntawd cov koob tshuaj insulin glargine, txaus siab qhov xav tau ntawm insulin basal, yuav tsum tsis pub dhau 40-60% ntawm qhov tshuaj insulin txhua hnub.

Hauv cov neeg mob uas muaj ntshav qab zib hom 2 uas tab tom kho nrog cov tshuaj hypoglycemic qhov ncauj, kev kho mob ua ke yuav tsum tau pib nrog ib koob tshuaj insulin 10 IU 1 zaug hauv ib hnub nrog kev kho tus neeg tom qab ntawm kev kho tus mob.

Yog hais tias kev kho mob yav dhau los suav nrog nruab nrab lossis ua yeeb yam ntev ntev, tom qab ntawd hloov tus neeg mob mus rau kev siv tshuaj insulin glargine, nws yuav tsim nyog hloov lub koob tshuaj thiab lub sijhawm ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin (lossis nws cov tshuaj tiv thaiv) thaum nruab hnub lossis los kho lub koob tshuaj ntawm qhov ncauj hypoglycemic.

Thaum hloov mus rau tus neeg mob los ntawm kev tswj hwm kev noj tshuaj daim ntawv ntawm cov tshuaj insulin glargine, muaj 300 IU hauv 1 ml, los tswj cov tshuaj Insulin glargine, thawj zaug tshuaj yuav tsum yog 80% ntawm cov koob tshuaj dhau los, kev siv ntawm qhov uas tau txiav tawm, thiab tseem yuav tsum tau noj ib hnub ib zaug. Qhov no yuav txo qhov kev pheej hmoo ntawm hypoglycemia.

Thaum hloov los ntawm kev tswj hwm ntawm insulin-isophan 1 zaug nyob rau ib hnub, thawj koob tshuaj insulin glargine feem ntau tsis hloov thiab raug tswj 1 zaug nyob rau ib hnub.

Thaum hloov los ntawm kev tswj hwm ntawm insulin-isofan 2 zaug hauv ib hnub rau kev tswj hwm ib zaug ntawm insulin glargine thaum mus pw, nws pom zoo tias qhov pib siv thawj zaug ntawm cov tshuaj yuav tsum txo qis 20% los ntawm qhov kev siv tshuaj txhua hnub dhau los ntawm insulin-isofan. Cov hauv qab no qhia tau hais tias nws kho lus nyob ntawm tus neeg li cas.

Tom qab pib kho nrog tib neeg cov tshuaj insulin, insulin glargine yuav tsum tau pib nyob rau hauv kev saib xyuas kev noj qab haus huv nkaus xwb, suav nrog kev saib xyuas cov concentration ntawm cov piam thaj hauv cov ntshav. Hauv thawj lub lis piam, yog tias tsim nyog, tshuaj rau txoj kev noj tshuaj yog kho tau. Qhov no muaj tseeb tshwj xeeb tshaj yog rau cov neeg mob uas muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin uas yuav tsum tau txhaj tshuaj kom ntau ntxiv ntawm tib neeg cov insulin. Lawv siv insulin glargine, uas yog ib qho piv txwv ntawm cov tshuaj insulin, tuaj yeem ua rau muaj kev txhim kho tseem ceeb hauv cov lus teb rau insulin.

Nrog rau qhov nce ntawm cov nqaij hauv rhiab rau insulin vim tias kev txhim kho metabolic tswj tau, kev txhim kho ntawm cov tshuaj ntau dua yog ua tau.

Hauv cov neeg mob uas muaj ntshav qab zib mellitus hauv cov neeg laus, nws raug nquahu kom siv cov tshuaj nruab nrab thiab kev saib xyuas cov tshuaj insulin glargine thiab maj mam nce ntxiv. Nws yuav tsum tau yug los hauv lub siab tias hauv lub hnub nyoog laus txoj kev paub txog kev txhim kho hypoglycemia yog qhov nyuaj.

Cov lus qhia thiab daim ntawv ntawm kev tso tawm

Lub ntsiab tseem ceeb ntawm cov tshuaj yog hluavtaws insulin Glargin. Tau txais los ntawm kev hloov kho DNA ntawm cov kab mob Escherichia coli (lub zog K12). Kev qhia siv yog insulin-tiv thaiv ntshav qab zib mellitus hauv cov menyuam yaus hnub nyoog ntau dua 6 xyoo, cov hluas thiab cov laus.

Thaum siv kom raug, cov tshuaj muab:

normalization ntawm cov metabolism hauv cov txheej txheem - qabzib ntau lawm thiab carbohydrate metabolism,
kev tsim tawm ntawm cov insulin receptors nyob rau hauv cov leeg nqaij thiab cov rog rog subcutaneous,
qab zib nqus los ntawm cov pob txha pob txha, cov leeg nqaij thiab cov rog rog subcutaneous,
kev ua kom muaj zog ntawm cov hluavtaws uas ploj lawm,
txo qis hauv kev tsim cov piam thaj ntau heev hauv lub siab.

Daim foos ntawm cov tshuaj yog kev daws teeb meem. Glargin muag hauv 3 ml cartridges lossis hauv 10 ml vials.

Pharmacological kev txiav txim

Qhov tseem ceeb ua haujlwm ntawm Glargin insulin, zoo ib yam li lwm yam insulin, yog kev cai ntawm cov metabolism hauv cov piam thaj. Cov tshuaj txo qis ntshav qabzib los ntawm kev ua kom cov piam thaj muaj peev xwm los ntawm cov ntaub so ntswg peripheral (tshwj xeeb tshaj yog cov leeg pob txha thiab cov nqaij mos adipose), nrog rau kev ua kom tsis qab los ntawm kev tsim cov piam thaj hauv lub siab. Insulin Glargin inhibits lipolysis hauv adipocytes, inhibits proteolysis thiab txhim kho synthesis protein.

Insulin Glargin tau txais los ntawm kev qhia txog ob qho kev hloov pauv hloov mus rau hauv cov qauv ntawm cov neeg insulin: ib txwm hloov ntawm haiv neeg asparagine nrog glycine amino acid ntawm txoj haujlwm A21 ntawm A saw thiab ntxiv ob lub arginine lwg me me rau NH2-kawg ntawm B saw.

Insulin Glargin yog cov tshuaj tiv thaiv tau zoo ntawm kev kho mob pH (pH 4) thiab muaj kev solubility qis hauv cov dej ntawm tus pH nruab nrab. Tom qab ua haujlwm subcutaneous, cov tshuaj acidic nkag mus rau qhov kev tiv thaiv nruab nrab nrog kev tsim cov microrecipients, los ntawm cov khoom me me ntawm Glargin insulin maj mam tso tawm, muab qhov tsis yooj yim (tsis muaj qhov pom tseeb) cov profile ntawm qhov siab-sijhawm nkhaus rau 24 teev. Lub sijhawm ntev ntawm kev ua haujlwm ntawm Glargin insulin yog vim tus nqi txo ntawm nws qhov nqus, uas cuam tshuam nrog tus nqi qis tso tawm. Yog li, cov tshuaj muaj peev xwm tswj cov qib qis ntawm insulin hauv cov neeg mob ntshav qab zib nrog kev coj noj coj ua ib hnub ib zaug. Raws li kev tshawb fawb txawv teb chaws thiab chaw muag tshuaj, insulin Glargin yog qhov sib luag hauv kev ua haujlwm lom neeg nrog tib neeg cov insulin.

Cov lus qhia rau kev siv

Qhov ntau thiab tsawg ntawm cov tshuaj yog xaiv ib tus zuj zus rau txhua tus neeg mob. Qhov kev daws tau muab tshuaj subcutaneously 1 zaug hauv ib hnub. Nws raug nquahu kom ua qhov no tib lub sijhawm. Thaj chaw rau kev txhaj tshuaj yog subcutaneous adipose nqaij ntawm tus ncej puab, plab los sis xub pwg. Ntawm txhua qhov kev txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tau hloov.

Hauv hom 1 Ntshav Qab Zib, Glargin insulin yog qhov tseem ceeb. Rau hom 2 tus kab mob, nws yog siv los ua kev kho mob los yog sib xyaw nrog lwm tus neeg mob hypoglycemic.

Qee lub sijhawm cov neeg mob tau qhia kev hloov los ntawm nruab nrab lossis ntev ua yeeb yam insulin mus rau Glargin. Hauv qhov no, koj yuav tsum hloov pauv cov kev kho mob uas ua rau pom kev lossis kho qhov tshuaj txhua hnub ntawm cov tshuaj insulin niaj hnub.

Thaum hloov los ntawm Isofan insulin mus rau ib qho kev txhaj tshuaj ntawm Glargin, koj yuav tsum txo qis txhua hnub ntawm kev txhaj tshuaj basal insulin (los ntawm 1/3 hauv thawj lub lis piam ntawm kev kho). Qhov no yuav pab txo qis kev pheej hmoo ntawm kev txhim kho nocturnal hypoglycemia. Qhov yuav txo qhov ntau npaum li cas hauv ib lub sijhawm tau teev tseg los ntawm qhov nce ntawm cov tshuaj insulin luv luv.

Sab sij huam

Glargin yog ib cov tshuaj uas cuam tshuam rau cov txheej txheem hauv cov metabolism thiab cov ntshav qab zib.Nrog kev siv lub cev tsis muaj zog, siv tsis raug thiab qee qhov ntawm lub cev, ib qho tshuaj tuaj yeem ua rau tsis muaj qhov tsis zoo.

Lipodystrophy yog ib qho kev mob tshwm sim nrog kev puas tsuaj ntawm lub cev rog ntawm qhov chaw txhaj tshuaj ntawm qhov hormone. Hauv qhov no, qhov nqus thiab nqus cov tshuaj tsis muaj zog. Txhawm rau tiv thaiv cov tshuaj tiv thaiv no, koj yuav tsum tau txuas ntxiv rau thaj chaw ntawm kev tswj hwm ntawm insulin.

Mob Hypoglycemia yog ib yam kab mob pathological nyob rau hauv uas cov concentration ntawm cov piam thaj hauv cov ntshav txo qis heev (tsawg dua 3.3 mmol / l). Nws loj tuaj hauv qhov mob uas muaj cov tshuaj insulin ntau dhau rau tus neeg mob. Rov ua ntau cuam tshuam rau hauv nruab nrab lub paj hlwb. Ib tug neeg yws txog qhov tsis txaus thiab tsis meej pem, muaj teeb meem nrog kev sau cia. Hauv kev ua haujlwm nyuaj, muaj qhov ua tiav ntawm kev tsis nco qab. Nrog cov ntshav qog ua kom qis, ua kom sib zog ntawm tes, ib qho kev xav ntawm kev tshaib kev nqhis, lub plawv dhia ceev ceev thiab kev npau taws. Qee cov neeg mob yuav tawm hws heev.

Ua xua qhov tshwm sim. Cov no yog cov tshuaj tiv thaiv hauv zos: mob ntawm qhov chaw txhaj tshuaj, urticaria, liab thiab khaus, ntau yam pob. Nrog rau qhov ua kom lub cev tsis haum rau lub cev, bronchospasm, kev hloov kho cov tawv nqaij dav dav (feem ntau ntawm lub cev npog tau cuam tshuam), arterial hypertension, angioedema, thiab poob siab. Lub siab teb tshwm sim tam sim ntawd.

Kev phiv los ntawm sab ntawm cov cuab yeej siv qhov muag pom yog tsis txiav txim siab. Nrog rau cov kev cai ntawm cov piam thaj hauv cov ntshav, cov nqaij mos tau raug tswj thiab ua nruj. Qhov rov ua haujlwm ntawm lub lens ntawm lub qhov muag kuj hloov, uas ua rau pom kev puas tabkaum. Sij hawm dhau mus, lawv ploj yam tsis muaj kev cuam tshuam sab nraud.

Ntshav qab zib noj qab haus huv yog vascular cuam tshuam ntawm ntshav qab zib. Ua kom puas los ntawm kev puas tsuaj rau tus retina. Vim yog ib qho ua kom cov ntshav qab zib poob qis, cov chav kawm ntawm tus kab mob yuav loj tuaj. Muaj cov kab mob rov ua kom zoo, uas yog pom los ntawm cov ntshav tsis txaus thiab ua kom loj tshiab ntawm cov nkoj tshiab uas npog lub macula. Yog tias tsis kho, qhov kev pheej hmoo ntawm qhov ua tiav tsis pom kev nce ntxiv.

Thawj qhov kev pabcuam rau haus luam yeeb ntau dhau

Txoj kev poob rau hauv cov ntshav qab zib tshwm sim thaum noj ntau dua ntawm Glargin. Txhawm rau pab tus neeg mob, cia nws noj ib qho khoom noj uas muaj cov zom zom (piv txwv li, cov khoom lag luam confectionery).

Nws kuj tseem pom zoo kom ua kom paub txog glucacon intramuscularly lossis mus rau hauv cov rog subcutaneous. Tsis muaj ib yam dab tsi ua tau zoo yog kev txhaj tshuaj ntawm cov tshuaj dextrose.

Kev qoj ib ce yuav tsum raug txo kom tsawg. Tus kws kho mob yuav tsum kho cov kev cai ntawm cov tshuaj thiab kev noj haus.

Yeeb tshuaj sib cuam tshuam

Glargin yog tsis sib xws nrog hom tshuaj ntsuab. Nws yog nruj me ntsis txwv tsis pub xyaw nrog lwm cov tshuaj los yog kev sib deev.

Ntau yam tshuaj ua rau cov metabolism hauv qabzib. Hauv kev hais txog qhov no, koj yuav tsum hloov lub koob tshuaj ntawm basal insulin. Cov no suav nrog pentoxifylline, MAO inhibitors, qhov ncauj hypoglycemic formulations, salicylates, ACE inhibitors, fluoxetine, disopyramide, propoxyphene, fibrates, sulfonamide tshuaj.

Txhais tau hais tias txo cov nyhuv hypoglycemic ntawm insulin suav nrog somatotropin, diuretics, danazole, estrogens, epinephrine, isoniazid, protease inhibitors, glucocorticoids, olanzapine, diazoxide, thyroid hormones, glucagon, salbutamol, clozapine, terbutagen, g.

Lithium ntsev, beta-blockers, haus dej cawv, clonidine tuaj yeem txhim kho lossis ua kom cov nyhuv tsis muaj zog ntawm insulin.

Cev xeeb tub thiab lactation

Cov poj niam uas xeeb tus menyuam yog raug saib xyuas tsuas yog tom qab sab laj nrog tus kws khomob koom nrog. Kev siv cov tshuaj yuav pom zoo yog tias muaj peev xwm muaj txiaj ntsig rau tus poj niam cev xeeb tub outweighs qhov pheej hmoo rau tus me nyuam hauv plab. Yog tias tus me nyuam tseem nyob nrog mob ntshav qab zib hauv lub cev, nws yuav tsum tau soj ntsuam cov txheej txheem metabolic tsis tu ncua.

Hauv lub sijhawm thib 2 thiab 3 ntawm kev cev xeeb tub, qhov kev xav tau kev qog ntau lawm. Tom qab yug menyuam - poob tag. Koob tshuaj yuav tsum tau nqa tawm los ntawm kws tshaj lij. Thaum pub niam mis, kev xaiv thiab tswj cov koob tshuaj yog tseem xav tau.

Txhua lub sijhawm ntawm cev xeeb tub, nws yog ib qho tseem ceeb kom ua tib zoo xav txog qib ntawm cov piam thaj hauv cov ntshav.

Kev tiv thaiv kev nyab xeeb

Glargin, ua cov tshuaj siv ntev ntev, tsis siv rau cov mob ntshav qab zib ketoacidosis.

Nrog hypoglycemia, tus neeg mob muaj cov tsos mob qhia tias qhov txo qis hauv cov ntshav qabzib txawm ua ntej qhov no tshwm sim. Txawm li cas los xij, hauv qee cov neeg mob, lawv yuav tsis tshwm sim hlo li lossis tshaj tawm tsawg dua. Cov pab pawg muaj xws li:

cov neeg noj lwm yam tshuaj
laus neeg
cov neeg mob uas muaj ntshav qab zib ib txwm
cov neeg mob uas mob ntshav qab zib thiab neuropathy,
cov neeg muaj lub hlwb tsis meej,
cov neeg muaj kev qaug zog, maj mam txhim kho hypoglycemia.

Yog tias cov xwm txheej zoo li no tsis raug tshawb pom nyob rau lub sijhawm, lawv yuav ua daim ntawv foos hnyav. Tus neeg mob ntsib tus tsis nco qab, thiab hauv qee kis txawm tias muaj kev tuag.

Aspart (NovoRapid Penfill). Simulates insulin cov lus teb rau kev txais khoom noj. Nws ua rau ntus thiab tsis muaj zog txaus. Qhov no ua rau nws yooj yim los tswj koj cov ntshav qab zib.

Neej Neeg (Lizpro). Cov tshuaj muaj pes tsawg leeg ua ke tawm cov tshuaj lom neeg ib txwm muaj. Cov tshuaj ua kom nquag plias nkag mus rau hauv cov hlab ntshav. Yog tias koj qhia Humalog tib lub koob tshuaj thiab nyob rau lub sijhawm teem nruj me ntsis, nws yuav nqus tau 2 zaug sai dua. Tom qab 2 teev, cov ntsuas no rov qab zoo li qub. Siv tau ntev txog 12 teev.

Glulisin (Apidra) - ib qho insulin analogue nrog lub sijhawm luv tshaj. Los ntawm kev ua haujlwm hauv metabolic nws tsis txawv ntawm kev ua haujlwm ntawm cov tshuaj hormones ntuj, thiab los ntawm pharmacological thaj chaw - los ntawm Humalog.

Ua tsaug rau ntau cov kev tshawb fawb thiab kev txhim kho, muaj ntau cov tshuaj zoo rau ntshav qab zib. Ib ntawm lawv yog Insulin Glargin. Nws yog siv raws li kev ywj pheej hauv kev kho mob monotherapy. Qee zaum nws cov tshuaj nquag muaj nyob hauv lwm cov tshuaj, piv txwv li, Solostar lossis Lantus. Cov tom kawg muaj txog 80% cov tshuaj insulin, Solostar - 70%.

Kws Tshuaj

Nws khi rau cov kab mob insulin tshwj xeeb (qhov khi tsis haum yog nyob ze rau cov tib neeg ntawm insulin), nws ua rau cov roj ntsha zoo ib yam li cov insulin endogenous. Regulates cov metabolism hauv qabzib. Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib los ntawm kev ua kom cov piam thaj los ntawm qhov nqaij (tshwj xeeb cov leeg pob txha thiab cov nqaij mos), nrog rau qhov ua kom cov ntshav qabzib nyob hauv lub siab (gluconeogenesis). Cov tshuaj insulin inhibits adipocyte lipolysis thiab proteolysis, thaum ua kom cov protein synthesis zoo.

Tom qab kev qhia txog cov roj ntsha subcutaneous, cov tshuaj acidic yog nruab nrab nrog kev tsim cov microprecipitates, los ntawm cov kua tshuaj insulin glargine tso tawm tas li, muab qhov twv ua ntej, du (tsis muaj peaks) profile ntawm qhov nkhaus-sijhawm nkhaus, nrog rau lub sijhawm ua haujlwm ntev.

Tom qab kev tswj hwm sc, qhov pib ntawm kev tshwm sim tshwm sim, nruab nrab, tom qab 1 teev. Qhov nruab nrab ntawm kev ua yog 24 teev, qhov siab tshaj plaws yog 29 teev. Nrog rau kev tswj hwm ib hnub thaum nruab hnub, lub xeev qhov nruab nrab nruab nrab ntawm cov tshuaj insulin glargine nyob rau hauv cov ntshav tau mus txog hauv 2-4 hnub tom qab thawj koob tshuaj.

Kev sib piv kev kawm txog cov ntsiab lus ntawm cov tshuaj insulin glargine thiab insulin-isofan nyob rau hauv cov ntshav ntshav hauv cov neeg muaj mob thiab cov neeg mob ntshav qab zib mellitus tom qab sc tswj kev siv tshuaj tau qhia qeeb dua thiab ntev dua qhov kev nqus, nrog rau qhov tsis muaj lub siab tshaj plaws hauv insulin glargine piv rau insulin-isofan Cov.

Hauv tib neeg subcutaneous rog, insulin glargine yog ib feem los ntawm carboxyl kawg ntawm cov saw B los ua cov metabolites uas nquag: M1 (21 A -Gly-insulin) thiab M2 (21 A-G--des-30 B -Thr-insulin). Hauv ntshav, ob qho tib si tsis hloov pauv ntawm insulin glargine thiab nws cov khoom kom txav tau yooj yim.

Carcinogenicity, mutagenicity, muaj kev cuam tshuam ntawm kev muaj menyuam

Kev tshawb nrhiav 2 xyoos ntawm cov carcinogenicity ntawm insulin glargine tau ua hauv cov nas thiab nas thaum siv cov koob tshuaj ntau npaum li 0.455 mg / kg (kwv yees li 5 thiab 10 lub sijhawm ntau dua li cov koob tshuaj rau tib neeg nrog s / c tswj hwm). Cov ntaub ntawv tau txais tsis tso cai rau peb kos cov lus xaus kawg txog tus nas poj niam, vim muaj kev tuag nyob hauv txhua pab pawg, tsis hais koob tshuaj. Kev txhaj tshuaj histiocytomas raug kuaj pom ntawm cov txiv neej nas (cov lus hauv keeb kwm tseem ceeb) thiab hauv cov txiv neej cov nas (siv cov lus tseem ceeb) siv cov tshuaj tiv thaiv acidic. Cov qog no tsis tau tshawb pom hauv cov poj niam tsiaj siv ntsev tswj lossis ua kom cov kua dej hauv lwm cov kuab tshuaj. Qhov tseem ceeb ntawm qhov kev soj ntsuam no hauv tib neeg tsis paub.

Mutagenicity ntawm insulin glargine tsis pom nyob rau ntau qhov kev sim (Ames kuaj, ntsuas nrog hypoxanthine-guanine phosphoribosyltransferase ntawm cov hlwb mammalian), hauv kev sim rau cov chromosomal aberrations (cytogenetic) hauv vitro ntawm V79 hlwb, hauv vivo nyob ntawm hamster Suav).

Hauv qhov kev kawm txog kev xeeb tub, nrog rau kev tshawb nrhiav ua ntej thiab tom qab yug menyuam ntawm cov txiv neej thiab poj niam cov txiv neej ntawm s / c koob tshuaj insulin kwv yees li 7 lub sijhawm cov tshuaj pom zoo pib rau s / c tswj hwm hauv tib neeg, leej niam mob toxicity los ntawm koob tshuaj hypoglycemia, suav nrog ob peb neeg mob tuag taus.

Cev xeeb tub thiab lactation

Teratogenic cuam tshuam. Cov kev tshawb fawb luam thiab teratogenicity tau ua nyob hauv nas thiab Himalayan luav nrog sc tswj cov tshuaj insulin (insulin glargine thiab insulin tib neeg ib txwm muaj). Cov tshuaj insulin tau muab rau cov poj niam cov nas ua ntej sib deev, lub sijhawm sib koom ua ke thiab thoob plaws lub cev xeeb tub ntawm koob tshuaj txog li 0.36 mg / kg / hnub (kwv yees li 7 zaug siab tshaj qhov xav kom pib noj rau s / c tswj hwm hauv tib neeg). Hauv cov luav, cov tshuaj insulin raug tswj hwm thaum lub sijhawm organogenesis ntawm kev txhaj tshuaj ntawm 0.072 mg / kg / hnub (kwv yees li 2 zaug siab dua qhov pom zoo pib siv rau s / c tswj hwm hauv tib neeg). Qhov cuam tshuam ntawm insulin glargine thiab cov tshuaj insulin nyob rau hauv cov tsiaj no feem ntau tsis sib xws. Muaj tsis muaj qhov tsis taus thiab kev loj hlob embryonic thaum ntxov.

Rau cov neeg mob uas muaj ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj kev tswj hwm kev tsim nyog ntawm cov khoom noj hauv lub cev thoob plaws lub cev xeeb tub. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntxiv thaum lub sijhawm thib ob thiab thib peb. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Siv nrog ceev faj thaum cev xeeb tub (tsis muaj kev tswj hwm hauv chaw kuaj mob hauv cov poj niam cev xeeb tub tau ua).

FDA Fetal Action Qeb - C.

Siv nrog ceev faj thaum lub sijhawm pub niam mis (nws tsis paub meej tias insulin glargine ua tawm hauv niam cov kua mis ntawm cov poj niam). Hauv cov pojniam muaj menyuam, kev txhaj tshuaj thiab noj zaub mov kom haum.

Kev phiv los ntawm cov tshuaj insulin glargine

Kev ntshav siab - qhov tshwm sim uas tsis xav tau tshaj plaws ntawm kev kho mob insulin tuaj yeem tshwm sim yog tias cov koob tshuaj insulin ntau dhau los piv rau qhov xav tau. Kev tawm tsam ntawm kev mob ntshav qab zib siab heev, tshwj xeeb yog kev rov ua dua, tuaj yeem ua rau kev puas tsuaj rau cov hlab ntshav ntawm lub paj hlwb. Kev mob ntshav qog ntshav ntev thiab mob ntshav qab zib ntau tuaj yeem tsim kev hem thawj rau cov neeg mob lub neej. Cov tsos mob ntawm adrenergic txee-kev tswj hwm (ua kom lub cev sympathoadrenal ua teb rau cov ntshav qab zib tsawg) feem ntau ua ntej neuropsychiatric mob cuam tshuam nrog hypoglycemia (twilight nco qab los yog nws ploj, ua kom mob huam): kev tshaib kev nqhis, ua tsis taus pa, hws txias, tachycardia (sai ntawm kev txhim kho hypoglycemia thiab qhov tseem ceeb nws yog, qhov tseeb tshaj yog cov tsos mob ntawm adrenergic counter-kev cai).

Cov xwm txheej tsis zoo ntawm lub qhov muag. Cov kev hloov pauv tseem ceeb hauv cov kev cai ntawm cov piam thaj hauv cov ntshav tuaj yeem ua rau tsis pom kev ib ntus vim yog cov pauv ntawm cov nqaij mos thiab qhov ntsuas ntawm qhov muag ntawm lub lens ntawm lub qhov muag. Lub sijhawm ntev ua haujlwm ntawm cov ntshav qabzib txo cov kev pheej hmoo ntawm kev kho mob ntawm cov ntshav qab zib retinopathy. Insulin kho, nrog cov kev hloov pauv hauv cov ntshav qabzib, tuaj yeem ua rau muaj kev phom sij dua ib ntus dhau ntawm qhov mob ntshav qab zib. Hauv cov neeg mob uas muaj kev tu ncua sai, tshwj xeeb tshaj yog cov uas tsis tau txais kev kho mob photocoagulation, kev mob ntshav qab zib ntau tuaj yeem ua rau txoj kev txhim kho tsis pom kev hauv lub cev.

Lipodystrophy. Ib yam li lwm yam tshuaj insulin, lipodystrophy thiab ncua hauv zos hauv kev nqus / nqus ntawm insulin tuaj yeem txhim kho ntawm thaj chaw txhaj tshuaj. Hauv kev soj ntsuam hauv chaw kho mob thaum lub sij hawm kho insulin nrog insulin glargine lipodystrophy tau pom nyob rau hauv 1-2% ntawm cov neeg mob, thaum lipoatrophy feem ntau tsis xav txog. Kev hloov pauv tsis tu ncua ntawm cov chaw txhaj tshuaj hauv thaj chaw thaj tsam uas tau pom zoo rau kev tswj fwm ntawm cov tshuaj insulin tuaj yeem pab txo qis qhov kev txhaum ntawm cov tshuaj tiv thaiv no lossis tiv thaiv nws qhov kev txhim kho.

Cov kev tawm tsam hauv cheeb tsam hauv thaj tsam ntawm kev tswj hwm thiab kev fab tshuaj. Thaum kuaj mob thaum kho cov tshuaj insulin siv insulin, glargine cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj tau pom nyob rau hauv 3-4% ntawm cov neeg mob. Xws li suav xim liab, mob, khaus, ua pob, o, lossis o. Feem ntau cov kev tshwm sim me me nyob ntawm thaj chaw ntawm cov tshuaj insulin feem ntau daws nyob rau ib ntus ntawm ob peb hnub mus rau ntau lub lis piam. Kev ua xua ntawm cov hom hypersensitivity sai rau insulin yog qhov tsawg. Cov kev xav zoo rau cov tshuaj insulin (suav nrog insulin glargine) lossis cov neeg excipients tuaj yeem ua raws li cov tawv nqaij sawv cev dav dav, angioedema, bronchospasm, arterial hypotension lossis poob siab, thiab yog li yuav tsim kev hem thawj rau tus neeg mob lub neej.

Lwm yam tshuaj tiv thaiv. Kev siv cov insulin tuaj yeem ua rau tsim cov tshuaj tiv thaiv rau nws. Thaum lub sijhawm sim kho mob hauv cov pab pawg ntawm cov neeg mob kho nrog insulin-isofan thiab insulin glargine, kev tsim cov tshuaj tiv thaiv uas cuam tshuam rau tib neeg cov tshuaj insulin tau pom nrog tib zaus. Tsawg tsawg zaus, qhov kuaj pom cov tshuaj tiv thaiv kab mob rau insulin tuaj yeem xav tau qhov kev kho ntau npaum li cas los txhawm rau tshem tawm qhov nyiam los txhim kho hypo- lossis hyperglycemia. Tsis tshua muaj, insulin tuaj yeem ua rau kev ncua ntawm kev ncua ntawm sodium thiab kev tsim ntawm edema, tshwj xeeb tshaj yog yog tias muaj zog los kho cov tshuaj insulin ua rau muaj kev txhim kho yav dhau los tsis muaj txiaj ntsig ntawm kev ua tiav ntawm cov txheej txheem metabolic.

Kev sib txuam

Cov tshuaj tsis sib haum nrog kev daws teeb meem ntawm lwm cov tshuaj. Cov tshuaj insulin glargine yuav tsum tsis txhob xyaw nrog lwm cov tshuaj insulin lossis ua kom yaj (thaum sib xyaw los yog sib xyaw, nws qhov kev hloov pauv yuav hloov dhau los, ntxiv rau, sib xyaw nrog lwm cov insulins tuaj yeem ua rau dej nag). Ib tug xov tooj ntawm cov tshuaj cuam tshuam rau cov metabolism hauv cov piam thaj, uas yuav xav tau kev kho kom haum rau cov tshuaj insulin glargine. Cov tshuaj uas tuaj yeem txhim kho hypoglycemic ua haujlwm ntawm cov tshuaj insulin thiab nce qhov kev xav ua rau kev txhim kho hypoglycemia suav nrog qhov ncauj hypoglycemic, ACE inhibitors, disopyramides, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates thiab sulfonamide antimicrobials.Cov tshuaj uas tuaj yeem ua rau cov ntshav tsis txaus ntawm cov insulin muaj xws li glucocorticoids, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, somatotropin, sympathomimetics xws li epinephrine, salbutamol, terbutaline thiab thyroid hormones, inhibitors, protease inhibitors. clozapine.

Beta-blockers, clonidine, lithium ntsev, haus cawv - tuaj yeem ob leeg txhim kho thiab ua kom cov nyhuv tsis muaj zog ntawm insulin. Pentamidine tuaj yeem ua rau hypoglycemia, uas qee zaum hloov los ntawm hyperglycemia. Nyob hauv kev cuam tshuam ntawm cov tshuaj sympatholytic xws li beta-blockers, clonidine, guanfacine thiab reserpine, cov cim ntawm adrenergic counter-txoj cai yuav raug txo lossis ploj.

Cov ntaub ntawv dav dav

Cov tshuaj no zwm rau pab pawg ntawm cov tshuaj insulin. Nws lub npe lag luam yog Lantus. Tus neeg sawv cev yog siv los kho mob ntshav qab zib hom mob ntshav qab zib. Nws muaj raws li kev txhaj tshuaj. Cov kua nyeem tsis muaj xim thiab yuav luag pob tshab.

Insulin Glargin yog ib qho piv txwv ntawm cov tshuaj insulin uas tsim los ntawm kev siv tshuaj lom neeg. Txawv hauv kev ua haujlwm ntev. Cov tshuaj yuav pab txo cov piam thaj hauv cov neeg mob cov ntshav.

Cov kev tivthaiv tseem ceeb ntawm cov khoom muaj pes tsawg leeg yog insulin Glargin.

Ntxiv rau nws, txoj kev daws teeb meem suav nrog:

glycerol
zinc tshuaj dawb
metacresol
hydrochloric acid,
sodium hydroxide
dej.

Cov tshuaj raug tso cai tsuas yog siv tau kev tso cai los ntawm tus kws tshaj lij thiab hauv cov khoom siv tshuaj los ntawm nws, txhawm rau tiv thaiv cov teeb meem.

Cov chaw muag tshuaj

Cov nyhuv tseem ceeb ntawm cov tshuaj no yog qhov txo qis hauv qabzib. Qhov no tshwm sim los ntawm kev tsim txoj kev sib khi ntawm nws thiab cov tshuaj insulin. Ib txoj ntsiab cai zoo heev ntawm kev nqis tes ua yog ua los ntawm tib neeg cov insulin.

Cov piam thaj hauv cov piam thaj yog txhim kho los ntawm cov tshuaj ntawm cov tshuaj, raws li cov ntaub so ntswg peripheral pib noj nws ntau yam ntxiv.

Ntxiv rau, Glargin inhibits qhov ua haujlwm ntawm cov piam thaj hauv lub siab. Nyob rau hauv nws cov cawv, cov txheej txheem ntawm cov protein ntau yog ua kom nrawm. Cov txheej txheem lipolysis, ntawm qhov tsis sib haum, ua rau qeeb qis.

Tom qab nkag mus ntawm cov tshuaj tov rau hauv lub cev, nws yog nruab nrab, microprecipitate yog tsim. Cov tshuaj nquag muaj kev tswj hwm hauv lawv, uas yog maj mam tso tawm. Qhov no ua rau kom lub sijhawm ntawm cov tshuaj thiab nws cov smoothness, yam tsis muaj kev hloov pauv.

Glargin kev coj ua pib ib teev tom qab txhaj tshuaj. Nws mob tsawv rau txog ib hnub.

Kev taw qhia, txoj hauv kev ntawm kev tswj hwm, koob tshuaj

Txog kev kho kom zoo, cov lus qhia rau kev siv cov khoom yuav tsum ua raws. Cov cai ntawm kev pub nkag yog ib txwm piav qhia los ntawm tus kws khomob.

Insulin Glargin tsuas sau tseg yog tias muaj mob. Nws siv yog qhov tsim nyog rau ntshav qab zib hom tshuaj insulin - qhov no txhais tau hais tias tus kab mob no yog qhov laj thawj rau kev teem caij.

Txawm li cas los xij, cov tshuaj no tsis raug pom zoo rau txhua tus - cov kws kho mob tshwj xeeb yuav tsum kawm cov duab hauv chaw kho mob ntawm txhua kis.

Nws siv tau tso cai nyob rau hauv cov ntshav qab zib ntawm ob hom thawj thiab hom thib ob. Hauv thawj hom mob, cov tshuaj siv yog cov tshuaj tseem ceeb. Hauv lwm qhov teeb meem, Glargin tuaj yeem kho ob qho tib si hauv kev kho mob monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj.

Cov koob tshuaj ib txwm suav ib leeg zuj zus. Qhov no cuam tshuam los ntawm tus neeg mob lub cev nyhav, nws lub hnub nyoog, tab sis yam tseem ceeb tshaj plaws yog cov yam ntxwv ntawm tus kab mob. Thaum lub sijhawm kho, ib qho kev kuaj ntshav ntshav tau saib xyuas kom nkag siab meej txog cov tshuaj ua haujlwm li cas, thiab txo lossis nce qhov koob tshuaj nyob rau sijhawm.

Cov tshuaj yog siv rau hauv daim ntawv txhaj tshuaj, uas yuav tsum tau ua subcutaneously. Qhov ntau zaus ntawm kev txhaj tshuaj yog ib hnub ib zaug. Raws li cov lus qhia, nws yuav tsum ua lawv tib lub sijhawm - qhov no ua rau muaj kev ua haujlwm zoo thiab qhov tsis muaj qhov tshwm sim tsis zoo. Qhov koob txhaj tshuaj no tau muab tso rau ntawm lub xub pwg, tus ncej puab lossis hauv qhov nqaij me me ntawm cov nqaij rog ntawm lub plab. Txhawm rau kom tsis txhob muaj qhov tshwm sim tsis zoo, hloov chaw rau kev tswj hwm.

Cwj mem-yeeb yaj kiab video qhia txog kev tswj hwm cov tshuaj insulin:

Phiv thiab haus tshaj

Txawm tias thaum sau daim ntawv yuav tshuaj los ntawm kws kho mob, koj tuaj yeem tsis paub tseeb tias nws txoj kev siv yuav ua yam tsis muaj teeb meem. Txawm hais tias ua raws li cov lus qhia, tshuaj qee zaum muaj qhov tsis txaus ntseeg, uas cuam tshuam nrog tus cwj pwm ntawm tus kheej hauv lub cev. Yog li, cov kev mob tshwm sim.

Thaum siv cov tshuaj, teeb meem yuav tshwm sim xws li:

Kev ntshav siab. Qhov tshwm sim no tshwm sim nrog ib qho kev paub dhau ntawm cov tshuaj insulin hauv lub cev. Feem ntau nws cov tsos yog txuam nrog kev xaiv tsis raug ntawm cov tshuaj, tab sis qee zaum cov laj thawj yog kev cuam tshuam los ntawm lub cev. Xws li qhov kev ua txhaum yog qhov txaus ntshai heev, vim nws cuam tshuam rau kev ua haujlwm ntawm lub paj hlwb. Nrog rau cov ntshav qog ntshav qis thiab tsis muaj kev pab, tus neeg mob tuaj yeem tuag. Qhov kev txawv txav no yog ua los ntawm cov tsos mob xws li tsis nco qab, mob plawv, mob plab, ntswj, kiv taub hau.
Pom kev tsis pom kevCov. Nrog rau kev kho insulin, kev poob siab sai sai hauv cov ntshav qabzib qee zaum pom, uas tuaj yeem ua rau mob hlwb. Tus neeg mob lub zeem muag yuav tsis pom zoo, suav nrog dig muag.
LipodystrophyCov. Qhov hu ua kev ua txhaum nyob rau hauv tus txheej txheem ntawm kev kwv yees ib yam yeeb tshuaj xas. Qhov kab mob no tuaj yeem zam tau nrog kev pab los ntawm kev hloov pauv tsis tu ncua ntawm cov chaw txhaj tshuaj.
Kev ua xuaCov. Yog tias qhov kev ntsuas tsim nyog rau kev nkag siab zoo rau cov tshuaj tau tshwm sim ua ntej siv Glargin, cov kev xav zoo li no tsis tshua muaj tshwm sim thiab tsis txawv hauv qhov tsis zoo. Cov yam ntxwv pom tseeb tshaj plaws nyob rau hauv cov ntaub ntawv no: tawv nqaij ua pob, liab ntawm daim tawv thiab khaus ntawm qhov chaw txhaj tshuaj.

Yog tias koj pom cov yam ntxwv zoo li no, tsis hais lawv siv ntau npaum li cas, koj yuav tsum tau sab laj nrog kws kho mob. Hauv qee kis, koj tuaj yeem tshem tawm ntawm lawv los ntawm kev hloov chaw ntawm cov tshuaj. Thiab qee zaum yuav tsum tau hloov tshuaj sai.

Ua raws li cov tshuaj ntawm tus kws kho mob tiv thaiv cov kev tsis zoo uas cuam tshuam nrog kev noj ntau dhau. Tab sis qee zaum qhov no tsis pab. Nyob rau hauv cov ntaub ntawv ntawm overdose, hypoglycemia feem ntau tshwm sim. Nws txoj kev tshem tawm yog nyob ntawm qhov mob hnyav ntawm cov tsos mob. Qee lub sij hawm nres kev tawm tsam yog tau los ntawm kev siv cov zom zaub mov carbohydrates. Nrog rau kev mob hnyav, kev pab ntawm kws kho mob yog qhov tsim nyog.

Kev sib xyaw thiab txoj ntsiab cai ntawm kev nqis tes ua

Qhov tseem ceeb cov tshuaj ntawm cov tshuaj yog insulin Glargin. Qhov no yog cov hluavtaws sib xyaw tau los ntawm txoj kev hloov kho. Nyob hauv tus txheej txheem ntawm nws qhov kev tsim, 3 lub ntsiab tseem ceeb yog hloov. Cov amino acid Asparagine hloov los ntawm Glycine hauv txoj saw A, thiab ob Arginines tau txuas nrog rau B txoj saw. Qhov tshwm sim ntawm qhov kev tso tawm no yog qhov ua tau zoo ntawm kev txhaj tshuaj, uas muaj cov txiaj ntsig zoo rau tsawg kawg 24 teev.

Cov tshuaj nquag, ntxiv nrog cov pabcuam ntu, muaj cov txiaj ntsig zoo rau tus neeg mob lub cev. Nrog rau kev siv kom tsim nyog ntawm insulin Glargin:

Cuam tshuam cov kab mob insulin uas muaj nyob hauv subcutaneous rog thiab cov leeg nqaij. Ua tsaug rau qhov no, cov nyhuv zoo ib yam li cov tshuaj insulin ntuj.
normalizes cov txheej txheem metabolism hauv kev ua haujlwm: cov khoom noj carbohydrate metabolism thiab piam thaj ntau lawm.
Stimulates glucose uptake los ntawm subcutaneous rog, cov leeg nqaij thiab cov leeg pob txha.
Txo cov khoom noj ntawm cov piam thaj ntau hauv lub siab.
Stimulates cov synthesis ntawm cov protein ploj.

Cov tshuaj nkag mus rau hauv cov khw muag tshuaj hauv daim ntawv ntawm kev daws: hauv 10 ml hwj los yog 3 ml cartridges. Nws siv sijhawm li ib teev tom qab kev tswj hwm.

Qhov siab kawg nkaus ntawm kev ua yog 29 teev.

Carcinogenicity thiab ua rau muaj peev xwm xeeb tub

Ua ntej muab muag, cov tshuaj tau sim rau cov carcinogenicity - lub peev xwm ntawm qee yam khoom siv los ua kom muaj kev pheej hmoo ntawm qog ua hlav thiab lwm cov kev hloov pauv. Muaj koob tshuaj insulin ntau ntxiv tau muab rau cov nas thiab nas. Qhov no coj mus rau:

Siab tuag nyob hauv txhua pab pawg ntawm cov tsiaj sim,
Cov hlav hlav hauv cov pojniam (hauv qhov chaw txhaj tshuaj),
Qhov qog ntawm cov qog thaum yaj hauv cov tshuaj lom neeg tsis-acidic.

Qhov kev ntsuam xyuas tau tshaj tawm lub siab toxicity tshwm sim los ntawm insulin dependence.

Lub peev xwm ua tim thiab yug tau tus menyuam hauv plab zoo dua tau hnov qab.

Noj ntau dhau

Cov tsos mob Mob ntshav qis thiab qee zaum ua rau muaj ntshav nce siab ntau, hem tus neeg mob lub neej.

Kev Kho Mob: Lub sijhawm mob ntshav qab zib tsawg kawg feem ntau tso tseg los ntawm kev noj zaub mov zom zaub mov kom yooj yim. Nws yog qhov tsim nyog yuav tsum hloov pauv kev noj tshuaj, tshuaj noj lossis ua haujlwm rau lub cev. Kev mob tshwm sim ntawm kev mob ntshav siab, nrog rau kev tsis nco qab, ua kom mob hlwb lossis mob hlwb, yuav tsum tso ntshav tshuaj lossis tshuaj mob ntshav qab zib, nrog rau kev tswj hwm ntawm cov tshuaj dextrose. Lub sijhawm ntev kom tau cov carbohydrate thiab kev saib xyuas tshwj xeeb yuav tsum tau ua, raws li Kev qog ntshav qab zib tuaj yeem rov tshwm sim tom qab pom kev txhim kho hauv chaw kho mob.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj Glargin muaj cov tshuaj insulin glargin - cov yeeb yaj kiab ua haujlwm ntev ntawm tib neeg cov tshuaj insulin. Cov tshuaj yuav tsum tau noj 1 zaug ib hnub ib txwm nyob rau tib lub sijhawm.

Cov koob tshuaj ntawm Glargin thiab lub sijhawm ntawm hnub rau nws kev tswj hwm raug xaiv ib tus zuj zus. Hauv cov neeg mob uas muaj ntshav qab zib hom 2, Glargin tuaj yeem siv tau ob qho tib si los ntawm kev kho mob hlwb thiab sib xyaw nrog lwm tus neeg sawv cev hypoglycemic. Cov kev ua ntawm cov tshuaj no yog qhia hauv cov koog (UNITS). Cov koog no tau siv tshwj xeeb rau Glargin: qhov no tsis zoo ib yam li cov khoom siv uas siv los nthuav qhia cov haujlwm ntawm lwm cov tshuaj insulin.

Cov neeg laus (tshaj 65 xyoo)

Hauv cov neeg laus neeg mob, lub raum tsis ua haujlwm tuaj yeem ua rau txo qis qis ntawm cov tshuaj insulin.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Hauv cov neeg mob uas lub raum khiav tsis zoo, qhov xav tau cov tshuaj insulin tuaj yeem txo vim yog txo qis hauv cov tshuaj insulin metabolism.

Glargin yuav tsum muab tshuaj subcutaneously ib txwm nyob rau tib lub sijhawm 1 zaug hauv ib hnub. Qhov kub ntawm cov tshuaj txhaj insulin yuav tsum sib haum rau chav tsev kub.

Tsis muaj qhov sib txawv hauv qhov kev paub tseeb los ntawm cov tshuaj insulin thiab cov piam thaj tom qab Glargine tau txhaj rau cov roj hauv plab, lub xub pwg, lossis ncej puab. Hauv tib thaj chaw ntawm kev tswj hwm tshuaj, nws yog qhov tsim nyog yuav tsum hloov chaw txhaj tshuaj txhua zaus.

Thaum qhia, ua raws cov lus qhia:

1. Glargin insulin tov yuav tsum pom tseeb thiab tsis muaj xim. Tsis txhob siv txoj kev daws teeb meem yog tias nws zoo li huab, thickened, me ntsis xim los yog pom pom cov khoom seem.

2. Thaum siv cov insulin cartridge, ua raws li cov lus qhia rau kev siv nrog tsim nyog Beijing Gangan Technology. Co. LTD., Suav.

3. Ua ntej siv tshuaj subcutaneous, kho thaj chaw txhaj tshuaj nrog tshuaj tua kab mob. Cov tshuaj feem ntau yog siv subcutaneously hauv plab, xub pwg lossis ncej puab. Nrog txhua txoj kev txhaj tshuaj, nws yog ib qho tsim nyog yuav tau hloov mus rau qhov chaw txhaj tshuaj.

4. Ua daim tawv nqaij ua ke nrog koj cov ntiv tes, ntxig rab koob rau hauv qhov chaw txhaj tshuaj thiab tom qab ntawm koj cov ntiv tes. Maj mam nias ntawm lub piston ntawm rab koob txhaj tshuaj thaum lub sijhawm tag nrho cov thawj coj ntawm cov tshuaj. Ob peb feeb tom qab kev siv tshuaj insulin, tshem tawm rab koob thiab nias qhov chaw txhaj tshuaj nrog rab qau ntawm ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj txhawm rau kom tsis txhob muaj kev puas tsuaj rau lub cev subcutaneous lossis roj av txau ntawm cov tshuaj.

Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic rau Glargin

Thaum hloov cov tshuaj kho nrog rau lwm cov tshuaj insulins nrog Glargin insulin kev kho mob, nws yuav tsum tau kho qhov tshuaj txhua hnub ntawm Glargin, thiab nws kuj yuav tsum tau kho cov tshuaj ntawm concomitant antidiabetic tshuaj (sai ua yeeb yam insulin, ua yeeb yam luv luv insulin analogue, tshuaj tiv thaiv kab mob hauv lub qhov ncauj).

Thaum hloov cov neeg mob los ntawm hom kev tswj hwm ntawm tib neeg cov tshuaj insulin ntawm qhov nruab nrab ntawm cov hnub nyoog ib hnub ob zaug rau kev tswj hwm ntawm insulin Glargin ib zaug ib hnub nyob rau thawj lub lim tiam ntawm kev kho mob, thawj koob tshuaj insulin Glargin yuav tsum txo 20-30% piv rau tag nrho cov tshuaj txhua hnub ntawm tib neeg insulin ntawm nruab nrab ncua. Yog hais tias ua tsis tau zoo tswj ntshav qabzib, qhov tshuaj yuav tsum raug kho raws li kws kho mob pom zoo.

Hauv cov neeg mob tau txais kev txhaj tshuaj ntau ntawm cov neeg nruab nrab lub cev ntev, vim tias muaj cov tshuaj tiv thaiv rau tib neeg insulin thaum hloov mus rau Glargin, kev txhim kho hauv cov lus teb tau.

Thaum lub sijhawm hloov mus thiab hauv thawj ob peb lub lis piam ntawm kev kho, nws yog qhov tsim nyog los tswj cov theem ntawm cov piam thaj hauv cov ntshav thiab ua tib zoo kho cov tshuaj noj.

Nyob rau hauv cov ntaub ntawv ntawm kev cai kho cov metabolism hauv thiab qhov tshwm sim ntau ntxiv hauv rhiab rau insulin, kev kho ntxiv ntawm kev ntau dua kev tswj hwm yuav tsim nyog. Kev hloov kho koob tshuaj kuj tseem xav tau, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, lub sijhawm rau hnub rau kev siv tshuaj yeeb tshuaj, lossis lwm yam xwm txheej uas ua rau muaj kev cuam tshuam ntau ntxiv rau kev txhim kho hypo- lossis hyperglycemia.

Sab sij huam

Kev Hypoglycemia: Kev mob ntshav qab zib yog tshwm sim los ntawm kev qhia txog hom insulin tsis yog, ntau dhau lawm cov koob tshuaj insulin thiab / lossis kev noj haus tsis raug cai nrog rau kev tawm dag zog.

Lipodystrophy: Yog tias koj tsis hloov thaj chaw ntawm cov tshuaj insulin, atrophy ntawm subcutaneous rog lossis lipid hyperplasia yuav tshwm sim.

Kev ua xua tsis haum: Nrog rau kev kho tshuaj insulin, kev tsis haum tshuaj hauv zos tuaj yeem tshwm sim hauv thaj chaw txhaj tshuaj, xws li liab, mob, khaus, ua xua, o thiab o. Cov kev tshwm sim no ib txwm tsis tseem ceeb thiab feem ntau ploj nrog kev txuas ntxiv ntawm kev kho. Cov kev tsis haum rau lub cev tsis tshua muaj tshwm sim. Nrog lawv txoj kev txhim kho, ib qho kev hem thawj rau lub neej ntawm tus neeg mob yuav tshwm sim.

Cov xwm txheej tsis zoo los ntawm cov plab hnyuv siab raum ntawm lub zeem muag: Ib qho kev hloov pauv tseem ceeb ntawm cov kev cai ntawm cov piam thaj hauv cov ntshav tuaj yeem ua rau tsis pom kev ib ntus.

Txhim kho cov ntshav qabzib tswj nrog kev siv tshuaj insulin ntau dua tuaj yeem ua rau lub sijhawm tsis ntev los ntawm kev mob ntshav qab zib. Nrog rau kev txhim kho ntawm cov ntshav qog ntshav, kev cia li tsis pom kev sai sai yuav tshwm sim hauv cov neeg mob uas muaj kev tiv thaiv kab mob hlwb (tshwj xeeb tshaj yog nyob rau cov neeg mob tsis tau txais kev kho laser coagulation). Kev ncua sijhawm ntev ntawm cov ntshav qabzib hauv cov ntshav yuav txo qhov kev pheej hmoo ntawm kev tsim muaj ntshav qab zib ua kom rov ua haujlwm dua.

Lwm yam kev cuam tshuam: Thaum siv insulin, kev tsim cov tshuaj tiv thaiv rau nws tuaj yeem pom. Hauv kev kho nruab nrab-lub sij hawm tshuaj insulin thiab insulin Glargin, kev tsim cov tshuaj tiv thaiv kab mob sib kis nrog tib neeg cov tshuaj insulin thiab insulin Glargin tau pom nrog tib zaus. Muaj qee zaus, qhov tshwm sim ntawm cov tshuaj tiv thaiv rau insulin tuaj yeem xav kho qhov kev txhaj tshuaj ntawm cov tshuaj insulin kom thiaj li yuav muaj cov suab thaj nyob rau hauv cov ntshav.

Tsis tshua muaj xwm txheej, tshuaj insulin, tshwj xeeb tshaj yog nrog kev siv tshuaj insulin ntau dua, tuaj yeem ua rau kom sodium khaws cia thiab qhov tsim ntawm edema.

Daim ntawv thov nta

Siv rau menyuam yaus

Qhov kev nyab xeeb thiab ua haujlwm ntawm Glargin cov tshuaj insulin rau hauv cov menyuam yaus uas muaj ntshav qab zib yuav tsum raug ntsuas raws nws cov ntaub ntawv siv.

Siv rau cov neeg laus

Qhov xav tau cov tshuaj insulin nyob rau hauv cov neeg laus cov neeg mob ntshav qab zib tuaj yeem txo qis thaum muaj mob raum.

Txais tos thaum cev xeeb tub thiab lactation

Cov poj niam ua menyuam yaus, cov tshuaj yog tshwm sim tsuas yog tom qab kev sab laj ua ntej. Cov tshuaj tau sau tseg hauv qhov xwm txheej uas muaj txiaj ntsig zoo rau leej niam muaj qhov siab dua qhov kev pheej hmoo rau tus me nyuam hauv plab. Yog tias tus poj niam cev xeeb tub muaj ntshav qab zib hauv lub cev muaj mob, nws raug nquahu kom soj ntsuam cov txheej txheem metabolic tas li.

Hauv lub sijhawm thib 2 thiab 3 ntawm kev cev xeeb tub, xav tau cov tshuaj insulin ntau ntxiv. Tom qab yug menyuam, xav tau cov tshuaj txo ntau.

Txhua lub hlis twg kev xeeb tub, koj yuav tsum ua tib zoo saib xyuas ntshav qab zib thiab soj ntsuam nws qib kom huv.

Lwm yam tshuaj siv tau

Tus nab npawb ntawm cov tshuaj cuam tshuam tsis zoo rau cov metabolism hauv metabolism. Hauv cov xwm txheej no, cov koob tshuaj insulin yuav tsum tau hloov pauv. Cov tshuaj uas txo cov piam thaj ntau ntau xws li:

ACE thiab MAO inhibitors,
Disopyramides,
Salicylates thiab sulfanide tus neeg sawv cev tawm tsam microbes,
Fluoxetine,
Ntau yam fibrates.

Qee cov tshuaj muaj peev xwm txo cov qog ntshav hypoglycemic: Cov tshuaj glucocorticosteroids, diuretics, danazol, glucagon, isoniazid, diazoxide, estrogens, gestagens, thiab lwm yam. Rau cov npe tag nrho ntawm cov tshuaj siv tsis tau, saib cov lus qhia ntim.

Kev ntshav siab

Qhov no yog ib qho kab mob pathological uas cov ntshav qab zib kom ntshav tau tsawg dua (tsawg dua 3.3 mmol / l). Nws tshwm sim hauv qhov xwm txheej ntawm qhov kev txhaj tshuaj insulin ntau dhau rau tus neeg mob, ntau heev tshaj qhov nws xav tau. Yog tias hypoglycemia yog mob hnyav thiab tshwm sim rau lub sijhawm, nws yuav hem ib tus neeg lub neej. Rov ua phem rau cuam tshuam rau lub paj hlwb. Tus neeg lub siab yuav dhau los ua huab thiab tsis meej pem, thiab nws nyuaj rau tus neeg mob mloog.

Hauv cov xwm txheej siab, ib tus neeg ua rau nws poob siab kiag li. Nrog cov ntshav qog ua kom qis, ib tus neeg txhais tes tshee tshee, nws ib txwm xav noj, yog yooj yim khaus thiab muaj mob hauv lub plawv dhia ceev. Qee tus neeg mob tau nce hws.

Kev ua xua tsis haum

Cov no yog cov tshuaj tiv thaiv hauv zos: urticaria, ntau cov pob, liab thiab khaus, mob ntawm qhov chaw txhaj tshuaj. Kev tsis haum rau cov tshuaj insulin: cov kev tawm tsam ntawm daim tawv nqaij thoob plaws (yuav luag txhua daim tawv raug cuam tshuam), bronchospasm, angioedema, poob siab, lossis hlab ntsha txhaws. Cov kev coj ua no tshwm sim sai thiab tsim kev puas tsuaj rau tus neeg mob lub neej.

Tsis tshua muaj xwm txheej, kev qhia txog cov tshuaj hormones muab cov tshuaj tiv thaiv ntxiv - sodium tuav, kev tsim cov edema thiab tsim cov tshuaj tiv thaiv kab mob rau insulin tswj hwm. Hauv qhov xwm txheej no, cov koob tshuaj ntawm cov tshuaj yuav tsum tau kho.

Nyob rau hauv cov teeb meem no qhov zoo li yuav ua rau muaj ntshav txham nce zuj zus

Yog tias koj ua raws li cov txheej txheem sau tseg, soj ntsuam cov ntshav qab zib kom tsawg thiab noj kom raug, qhov yuav ua rau muaj ntshav siab tsawg yog qhov tsawg kawg nkaus. Yog tias muaj lwm yam ntxiv, hloov cov koob tshuaj.

Cov laj thawj uas ua rau kom muaj cov kua nplaum txo qis muaj xws li:

Kev tsis haum xeeb rau insulin,
Hloov cov cheeb tsam uas cov tshuaj no tau tshaj tawm,
Txuam kab mob nrog cov quav tsis hnov lus (zawv plab) thiab ntuav, ua rau muaj kev mob ntshav qab zib,
Lub cev ua ub no tsis zoo rau tus neeg mob lub cev,
Cawv kev quav cawv
Ua txhaum cov khoom noj thiab siv cov khoom noj tsis raug txwv,
Lub qog ua haujlwm tsis zoo
Ua ke nrog kev sib txuas nrog cov tshuaj tsis haum.

Nrog rau cov kab mob sib xyaw thiab kis tau tus mob, kev tswj cov ntshav qab zib yuav tsum muaj txhij txhua ntxiv.

Muab ntshav thiab zis tsis tu ncua rau kev sim ntau. Yog tias tsim nyog, kho qhov koob tshuaj insulin (tshwj xeeb tshaj yog rau ntshav qab zib hom 1).

Insulin Glargin: cov lus qhia rau kev siv

Cov khoom yog ua tib zoo txhaj rau hauv lub cev hauv plab thaj tsam, ncej puab thiab xub pwg. Cov tshuaj hormones analogue yog siv 1 zaug hauv ib hnub nyob rau ib lub sijhawm. Lwm qhov chaw txhaj tshuaj kom tsis txhob ntim thiab lwm qhov tsis zoo. Nws yog txwv tsis pub txhaj tshuaj rau hauv cov leeg ntshav.

Lub npe kev lag luam, tus nqi, chaw cia khoom

Cov tshuaj muaj nyob hauv qab cov npe kev lag luam:

Lantus - 3700 rubles,
Lantus SoloStar - 3500 rubles,
Insulin Glargin - 3535 rubles.

Khaws rau hauv tub yees ntawm qhov kub ntawm 2 txog 8 degrees. Tom qab qhib, khaws cia rau hauv qhov chaw tsaus thiab tawm ntawm qhov chaw ncav cuag ntawm cov menyuam, ntawm qhov kub txog li 25 degrees (tsis nyob hauv tub yees).

Cov tshuaj Insulin Glargin: analogues

Yog hais tias tus nqi ntawm cov tshuaj Insulin glargine tsis haum koj lossis yog tias muaj ntau yam tsis xav tau txoj kev loj hlob los ntawm nws qhov kev saws me nyuam, hloov cov tshuaj nrog ib qho ntawm cov analogues hauv qab no:

Humalog (Lizpro) yog ib yam tshuaj uas nyob hauv cov qauv zoo li lub cev insulin. Cov xov tooj hlau yog nqus sai rau hauv cov hlab ntshav. Yog tias koj tswj cov tshuaj tsuas yog nyob rau lub sijhawm teem ntawm lub hnub thiab tib lub sijhawm, Humalog yuav nqus 2 zaug sai dua thiab yuav mus txog qib yam xav tau hauv 2 teev. Lub cuab tam siv tau ntev txog 12 teev. Tus nqi ntawm Humalog yog los ntawm 1600 rubles.
Aspart (Novorapid Penfill) yog ib yam tshuaj uas cuam tshuam cov tshuaj insulin rau kev noj zaub mov. Nws ua haujlwm tsis tshua muaj zog thiab lub sijhawm luv luv, uas ua rau nws yooj yim los tswj cov qib ntawm cov piam thaj hauv cov ntshav. Tus nqi ntawm cov khoom yog los ntawm 1800 rubles.
Glulisin (Apidra) yog qhov tshuaj yeeb yaj kiab luv ntawm kev siv tshuaj insulin. Los ntawm pharmacological thaj chaw nws tsis txawv ntawm Humalog, thiab los ntawm kev ua haujlwm ntawm metabolic - los ntawm ntuj insulin tsim los ntawm tib neeg lub cev. Tus nqi - 1908 rubles.