Ntsiav tshuaj - 1 ntsiav tshuaj:

Cov tshuaj ua kom nquag plias: metformin hydrochloride 500 mg / 850 mg / 1000 mg,
Cov muaj mob: hypromellose 2208 5.0 mg / 8.5 mg / 10.0 mg, povidone K90 (collidone 90F) 20.0 mg / 34.0 mg / 40.0 mg, sodium stearyl fumarate 5.0 mg / 8, 5 mg / 10.0 mg
Cov dej ua kua xim zaj duab xis zaj duab xis: hypromellose 2910 7.0 mg / 11.9 mg / 14.0 mg, polyethylene glycol 6000 (macrogol 6000) 0.9 mg / 1.53 mg / 1.8 mg, polysorbate 80 (kaum 80) 0, 1 mg / 0.17 mg / 0.2 mg, titanium dioxide 2.0 mg / 3.4 mg / 4.0 mg.

Zaj duab xis-cov ntsiav tshuaj 500 mg, 850 mg, 1000 mg.

Thawj lub ntim tshuaj

Ntawm 10 ntsiav tshuaj nyob rau hauv lub hlwv sawb ntim los ntawm ib zaj duab xis ntawm polyvinyl chloride thiab ib daim ntawv luam ntawm txhuas ntawv ci varnished.

Rau 15, 30, 60, 100, 120 ntsiav tshuaj hauv lub thawv polymer ua los ntawm polyethylene nrog lub hau nrog ncab nrog kev tswj ntawm thawj qhib. Qhov chaw pub dawb yog muaj paj rwb kho mob. Cov ntawv lo ua cov ntawv sau lossis ntawv sau, los yog tus kheej-cov nplaum rau cov ntawv polymeric, yog lo rau ntawm ntug dej.

Thib ob ntim tshuaj

1, 2, 3, 4, 5, 6, 8, 9, lossis 10 blister pob ntawv, ua ke nrog cov lus qhia rau kev siv, tau muab tso rau hauv pob ntawv los qhia rau cov neeg siv khoom ntim.

1 tuaj yeem ua ke nrog cov lus qhia rau kev siv yog muab tso rau hauv lub thawv ntim ntawm daim ntawv los rau cov neeg siv khoom ntim.

1000 mg ntsiav tshuaj: oblong biconvex ntsiav tshuaj coated nrog dawb zaj duab xis txheej nrog kev pheej hmoo ntawm ib sab. Hauv seem hla, qhov tseem ceeb yog dawb lossis yuav luag dawb.

Tus neeg sawv cev hypoglycemic ntawm biguanide pawg rau kev siv lub qhov ncauj.

Kev nqus thiab faib khoom

Tom qab cov neeg siv qhov ncauj, metformin yog nqus tau ntawm txoj hnyuv mus tag nrho. Kev tsis raug cai ntawm bioavailability yog 50-60%. Qhov siab tshaj plaws (Cmax) (kwv yees li 2 μg / ml lossis 15 μmol) hauv cov ntshav tau txog tom qab 2.5 teev. Nrog kev noj zaub mov ib txhij, kev nqus ntawm metformin yog txo thiab qeeb.

Metformin tau faib sai sai hauv cov ntaub so ntswg, kev xyaum ua haujlwm tsis khi rau cov ntshav protein.

Kev ntsuas phoo thiab nthuav tawm

Nws yog metabolized mus rau ib tug kawm ntawv uas tsis muaj zog thiab tawm los ntawm ob lub raum. Kev tshem tawm ntawm metformin hauv cov ntsiab lus noj qab haus huv yog 400 ml / min (4 lub sijhawm ntau dua li creatinine tshem tawm), uas qhia tias muaj cov kwj dej muaj kev zais cia. Ib nrab-lub neej yog kwv yees li 6,5 teev. Nrog raum tsis ua haujlwm, nws nce, muaj kev pheej hmoo ntawm kev txuam nrog cov tshuaj.

Metformin txo hyperglycemia yam uas tsis ua rau kev txhim kho ntshav qab zib hauv lub ntsej muag. Tsis zoo li sulfonylurea derivatives, nws tsis txhawb kev tiv thaiv insulin secretion thiab tsis muaj qhov cuam tshuam hypoglycemic hauv cov neeg noj qab haus huv. Tsub qhov rhiab heev ntawm peripheral receptors rau insulin thiab kev siv cov kua nplaum los ntawm lub hlwb. Txo cov ntshav qabzib ntau lawm los ntawm inhibiting gluconeogenesis thiab glycogenolysis. Ncua kev nqus cov hnyuv ntawm lub ntsej muag. Metformin stimulates glycogen synthesis los ntawm kev ua ntawm glycogen synthase. Tsub kom muaj peev xwm thauj tau txhua yam ntawm cov khoom thauj ua kua roj ntau dua. Tsis tas li ntawd, nws muaj txiaj ntsig zoo rau lipid metabolism: nws txo cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, cov lipoproteins tsawg thiab triglycerides.

Thaum noj cov tshuaj metformin, tus neeg mob lub cev hnyav dua li qub tseem ruaj khov lossis txo qis. Cov kev tshawb fawb soj ntsuam kuj tau qhia qhov ua tau zoo ntawm metformin rau kev tiv thaiv kab mob ntshav qab zib rau cov neeg mob ntshav qab zib nrog cov kev pheej hmoo ntxiv rau kev txhim kho kev mob hom ntshav qab zib hom 2 ntshav qab zib, uas txoj kev hloov pauv hauv lub neej tsis tso cai rau kev tswj glycemic txaus.

Kev Ntsuas Cov Lus Merifatin

Hom 2 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog rau cov neeg mob rog rog, nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab ua si lub cev:

hauv cov laus, raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm tus kab mob hauv lub qhov ncauj hypoglycemic lossis nrog insulin,
hauv cov menyuam yaus txij thaum 10 xyoo los ua kev kho mob lossis siv tshuaj insulin. Kev tiv thaiv tus kab mob ntshav qab zib hom 2 hauv cov neeg mob uas muaj ntshav qab zib nrog rau lwm qhov kev pheej hmoo los tsim tus mob ntshav qab zib hom 2, uas kev hloov pauv hauv lub neej tsis tso cai rau kev tswj ntshav ua kom tiav.

Cov Txheej Txheem Pom Zoo Merifatin

Hypersensitivity rau metformin lossis rau ib yam dab tsi,
ketoacidosis, mob ntshav qab zib precoma, coma,
lub raum tsis ua haujlwm lossis lub raum tsis ua haujlwm (creatinine tshem tawm tsawg dua 45 ml / min),
muaj mob hnyav nrog qhov muaj pheej hmoo ua mob rau lub raum: lub cev qhuav dej (nrog rau zawv plab, ntuav), cov kab mob kis hnyav, ua rau poob siab,
cov kab mob hais tawm los ntawm kev mob siab lossis mob mus ntev uas tuaj yeem ua rau kev tsim cov nqaij mos hypoxia (suav nrog mob plawv tsis ua haujlwm, mob plawv tsis ua haujlwm nrog tsis muaj ntshav hemodynamics, ua pa tsis ua haujlwm, mob myocardial infarction),
kev phais mob siab thiab mob siab rau thaum kev kho tshuaj insulin,
daim siab ua haujlwm, lub siab ua haujlwm tsis zoo,
haus cawv qaug cawv, qaug cawv lom,
cev xeeb tub
lactic acidosis (suav nrog keeb kwm),
thov rau tsawg dua 48 teev ua ntej thiab nyob rau hauv 48 teev tom qab ua kev tshawb fawb radioisotope lossis xoo hluav taws xob nrog kev qhia ntawm iodine-muaj qhov sib piv nruab nrab,
kev ua raws li cov zaub mov hypocaloric (tsawg dua 1000 kcal / hnub).

Siv nrog ceev faj cov tshuaj:

hauv cov neeg laus dua 60 xyoo uas ua haujlwm hnyav lub cev, uas cuam tshuam nrog kev pheej hmoo ntawm kev tsim mob lactic acidosis,
hauv cov neeg mob uas lub raum tsis ua haujlwm (creatinine tshem tawm 45-59 ml / min),
lub sijhawm pub niam mis.

Merifatin Siv rau hauv kev xeeb tub thiab menyuam yaus

Cov ntshav qab zib uas tsis tau them ua ke thaum cev xeeb tub yog qhov cuam tshuam nrog kev pheej hmoo ntawm kev yug menyuam thiab lub hnub tuag taus. Tsawg tsawg tus ntawm cov ntaub ntawv qhia tias kev noj cov tshuaj metformin rau cov poj niam cev xeeb tub tsis nce qhov kev pheej hmoo ntawm kev loj hlob ntawm kev yug hauv cov menyuam.

Thaum npaj lub cev xeeb tub, nrog rau kev xeeb tub ntawm keeb kwm yav dhau los ntawm kev noj cov tshuaj metformin nrog ntshav qab zib thiab hom ntshav qab zib hom 2, cov tshuaj yuav tsum tau txiav tawm, thiab yog tias muaj tus mob ntshav qab zib hom 2, kev kho tshuaj insulin yog kho. Nws yog ib qho tsim nyog yuav tsum ua kom tswj tau cov piam thaj hauv ntshav plasma ntawm cov ntshav nyob ze tshaj qhov qub kom txo tau qhov phom sij ntawm cov menyuam hauv plab.

Metformin hla mus rau hauv niam cov kua mis. Tsis pom cov kev mob tshwm sim hauv cov menyuam mos thaum lub sijhawm pub niam mis thaum tseem noj cov tshuaj metformin tsis tau pom. Txawm li cas los xij, vim tias muaj qee cov ntaub ntawv tsawg, kev siv cov tshuaj thaum lub sijhawm pub niam mis tsis pom zoo. Qhov kev txiav txim siab txog kev pub mis niam yuav tsum txiav txim siab txog txiaj ntsig kev pub mis niam thiab kev pheej hmoo ntawm kev phiv

Tso tawm daim ntawv, ntim thiab muaj pes tsawg leeg

Cov ntsiav tshuaj, coated nrog cov xim zaj duab xis txheej dawb, yog oblong, biconvex, nrog kev pheej hmoo ntawm ib sab, hauv qhov chaw hla ntu ib qho tseem ceeb ntawm cov xim dawb los yog yuav luag dawb xim.

1 tab
metformin hydrochloride	1000 mg

Tshwjxeeb: hypromellose 2208 - 10 mg, povidone K90 (collidone 90F) - 40 mg, sodium stearyl fumarate - 10 mg.

Cov dej ua kua xim zaj duab xis zaj duab xis: hypromellose 2910 - 14 mg, polyethylene glycol 6000 (macrogol 6000) - 1.8 mg, polysorbate 80 (kaum yim 80) - 0.2 mg, titanium dioxide - 4 mg.

10 Pcs - blister packs (1) - pob ntawv los ntawm cardboard.
10 Pcs - blister packagings (2) - pob ntawv los ntawm cardboard.
10 Pcs - blister packs (3) - pob ntawv ntawm cardboard.
10 Pcs - hlwv pob (4) - pob khoom los ntawm cardboard.
10 Pcs - blister pob (5) - pob ntawv ntawm cardboard.
10 Pcs - blister packagings (6) - pob ntawv ntawm cardboard.
10 Pcs - blister pob khoom (7) - pob ntawv ntawm cardboard.
10 Pcs - hlwv pob (8) - pob khoom los ntawm cardboard.
10 Pcs - blister packagings (9) - ntim cov duab los qhia.
10 Pcs - blister pob khoom (10) - pob ntawv ntawm cardboard.
15 Pcs. - cov kaus poom (1) - pob ntawm cardboard.
30 pcs - cov kaus poom (1) - pob ntawm cardboard.
60 pcs. - cov kaus poom (1) - pob ntawm cardboard.
100 pcs - cov kaus poom (1) - pob ntawm cardboard.
120 pcs - cov kaus poom (1) - pob ntawm cardboard.

Pharmacological kev txiav txim

Qhov ncauj hypoglycemic tus neeg sawv cev los ntawm pab pawg ntawm biguanides (dimethylbiguanide). Tus txheej txheem ntawm kev ua ntawm metformin yog txuam nrog nws lub peev xwm los txwv gluconeogenesis, nrog rau kev tsim cov roj dawb dawb thiab oxidation ntawm cov rog. Tsub qhov rhiab heev ntawm peripheral receptors rau insulin thiab kev siv cov kua nplaum los ntawm lub hlwb. Metformin tsis cuam tshuam rau cov tshuaj insulin hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov kua dej mus rau dawb thiab nce qhov feem ntawm cov insulin rau proinsulin.

Metformin stimulates glycogen synthesis los ntawm kev ua ntawm glycogen synthetase. Tsub kom muaj peev xwm thauj tau txhua yam ntawm cov khoom thauj ua kua roj ntau dua. Ncua kev nqus cov hnyuv ntawm lub ntsej muag.

Txo cov qib triglycerides, LDL, VLDL. Metformin kho txhim kho cov khoom fibrinolytic ntawm cov ntshav los ntawm kev tiv thaiv cov nqaij mos-plasminogen activator inhibitor.

Thaum noj cov tshuaj metformin, tus neeg mob lub cev hnyav dua li qub tseem ruaj khov lossis txo qis.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, metformin maj mam thiab ua tsis tiav cov pa hauv cov hnyuv. C max hauv ntshav tau mus txog tom qab li 2.5 teev. Nrog ib koob tshuaj 500 mg, qhov tsis txaus ntseeg tiag tiag txog 50-60%. Nrog kev noj ib txhij, kev nqus ntawm metformin yog txo thiab qeeb.

Metformin tau faib sai sai rau hauv cov ntaub so ntswg hauv lub cev. Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, mob siab thiab ob lub raum.

Nws yog tawm los ntawm lub raum tsis hloov pauv. T 1/2 los ntawm cov ntshav ntshav yog 2-6 teev.

Yog tias ua kom lub raum khiav tsis zoo, ua kom ntau ntawm metformin yog ua tau.

Tshuaj los qhia

Hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) nrog kev noj zaub mov noj thiab kev tawm dag zog tsis muaj zog, hauv cov neeg mob rog rog: hauv cov neeg laus - raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg lub qhov ncauj hypoglycemic lossis nrog insulin, hauv cov menyuam hnub nyoog 10 xyoo thiab laus dua - raws li kev kho mob monotherapy lossis txuam nrog cov tshuaj insulin.

ICD-10 cov lis dej num

ICD-10 code	Kev taw qhia
E11	Mob ntshav qab zib Hom 2

Kev noj tshuaj ntxiv

Nws yog noj ntawm qhov ncauj, thaum lossis tom qab noj mov.

Cov koob tshuaj thiab qhov ntau zaus ntawm cov thawj coj yog nyob ntawm daim ntawv ntau npaum siv.

Nrog kev kho mob monotherapy, thawj koob tshuaj rau cov neeg laus yog 500 mg, nyob ntawm daim ntawv ntau npaum li cas tau siv, qhov ntau zaus ntawm kev tswj hwm yog 1-3 zaug / hnub. Nws tuaj yeem siv 850 mg 1-2 zaug / hnub. Yog tias tsim nyog, cov koob tshuaj tau maj mam nce nrog qhov luv ntawm 1 lub lim tiam. txog li 2-3 g / hnub.

Nrog tshuaj monotherapy rau cov menyuam yaus hnub nyoog 10 xyoo thiab laus dua, thawj koob tshuaj yog 500 mg lossis 850 1 zaug / hnub lossis 500 mg 2 zaug / hnub. Yog tias tsim nyog, nrog kev ncua sij hawm tsawg kawg 1 lub lis piam, qhov koob tshuaj yuav raug nce ntxiv mus txog qhov ntau ntawm 2 g / hnub hauv 2-3 koob.

Tom qab 10-15 hnub, koob tshuaj yuav tsum tau kho raws cov txiaj ntsig kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Hauv kev kho ua ke nrog kev siv tshuaj insulin, thawj koob tshuaj metformin yog 500-850 mg 2-3 zaug / hnub. Cov koob tshuaj insulin raug xaiv raws li cov txiaj ntsig kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Sab sij huam

Los ntawm lub plab zom mov: muaj peev xwm (feem ntau thaum pib kho) xeev siab, ntuav, raws plab, pom, tsis xis nyob rau hauv plab, hauv cov kis mob cais tawm - qhov ua txhaum ntawm lub siab ua haujlwm, mob siab (ploj lawm tom qab kho yog nres).

Los ntawm ib sab ntawm cov metabolism: tsis tshua muaj - lactic acidosis (tsum tsis ua kev kho mob).

Los ntawm cov kab mob hemopoietic: tsis tshua muaj tshwm sim - kev ua txhaum ntawm kev nqus ntawm cov vitamin B 12.

Daim ntawv qhia txoj kev tsis haum ntawm cov menyuam yaus hnub nyoog 10 xyoo thiab laus dua yog qhov zoo tib yam rau cov neeg laus.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Nws yog tsim nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj nyob rau hauv ib tug npaum ntawm metformin: 500 mg, 850 mg, 1000 mg.

Kuj tseem muaj:

hypromellose 2208,
sodium stearyl fumarate,
povidone K90,
rau lub hau: hypromellose 2910,
titanium dioxide
polysorbate 80
polyethylene glycol 6000.

Nws tau ntim cov hlwv ntawm 10 daim, hauv daim npav card los ntawm 1 txog 10 blisters, lossis hauv cov khob ntim ntawm 15, 30, 60, 100 lossis 120 ntsiav tshuaj.

Cov lus qhia rau siv (qauv thiab ntau npaum li cas)

Merifatin noj ntawm qhov ncauj nrog lossis tom qab noj mov. Cov koob tshuaj yog xaiv ib qho zuj zus raws cov lus pov thawj thiab cov kev xav tau tiag tiag ntawm lub cev.

Kev kho mob pib nrog qhov tsawg kawg ntawm 500 mg 1-3 zaug hauv ib hnub. Yog tias tsim nyog, nws muaj peev xwm maj mam nce ntxiv - ib zaug txhua 1-2 lub lis piam, txhawm rau kom tsis txhob muaj qhov tsis zoo los ntawm txoj hnyuv plab. Qhov tshuaj ntau ntau yog 2-3 g ib hnub.

Rau cov menyuam yaus, cov tshuaj thawj zaug yog 500 mg 1-2 zaug ib hnub. Qhov siab tshaj plaws txhaj tshuaj yog 2 g nyob rau ib hnub hauv ntau koob.

Thaum kho nrog insulin, kev noj cov tshuaj metformin yuav tsum yog 500-850 mg 2-3 zaug hauv ib hnub, thiab qhov yuav tsum tau ntawm cov tshuaj hormone yog xaiv raws li cov ntaub ntawv tshawb xyuas.

Kev phiv los sis tshuaj:

lactic acidosis,
kev fab tshuaj tsis haum
xeev siab, ntuav,
teeb meem plab zom mov
nws yog xim hlau ci hauv qhov ncauj
malabsorption ntawm cov vitamin B12,
anemia
nrog kev kho mob ua ke - hypoglycemia.

Noj ntau dhau

Tej zaum qhov kev loj hlob ntawm cov kab mob lactic acidosis tshwm sim los ntawm kev txuam nrog metformin hauv lub cev. Nws cov tsos mob yog xeev siab, ntuav, raws plab, mob plab thiab mob leeg, ua tsis taus pa, lub cev kub tsis txias, lub xeev twilight nco qab mus txog thaum tsis nco qab. Yog tias cov tsos mob zoo li no tshwm sim, koj yuav tsum tsis txhob noj tshuaj tam sim ntawd, mus pw hauv tsev kho mob rau tus neeg mob thiab coj kev mob hemodialysis thiab kev kho mob yam ntxwv. Nov yog kev mob uas yuav txo tau txoj sia, tshwj xeeb tshaj yog rau cov neeg laus thiab menyuam, yog li nws tseem ceeb kom paub nws cov tsos mob.

Nrog rau kev siv tshuaj sib xyaw nrog lwm cov tshuaj kom txo cov ntshav qab zib, ntshav qab zib tsawg yuav tshwm sim. Nws cov tsos mob: tsis muaj zog, pallor, xeev siab, ntuav, tsis hnov qab (ua ntej ntog mus rau hauv coma), kev tshaib plab, thiab ntau dua. Nrog rau daim ntawv me me, ib tus neeg tuaj yeem ruaj khov nws tus mob los ntawm kev noj zaub mov ntau nyob rau hauv carbohydrates. Hauv cov foos thiab hnyav daim ntawv, yuav tsum tau txhaj tshuaj glucagon los yog dextrose tov yog qhov yuav tsum tau ua. Tom qab ntawd tus neeg xav tau coj mus rau hauv kev nco qab thiab tom qab ntawd muab cov khoom noj uas muaj cov khoom noj uas muaj carbohydrate. Nws yog qhov yuav tsum tau hais tias koj tom qab mus sab laj tus kws kho mob tshwj xeeb kom kho ntawm hom kev kho mob.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv ntawm kev kho mob nrog merifatin yog txhim kho los ntawm:

lwm cov neeg sawv cev hypoglycemic
beta blockers,
NSAIDs
danazol
chlorpromazine
clofibrate derivatives,
oxytetracycline
MAO thiab ACE inhibitors,
cyclophosphamide,
ethanol.

Cov nyhuv ntawm metformin yog qhov ua kom tsis muaj zog los ntawm:

glucagon,
epinephrine
thiazide thiab voj diuretics,
glucocorticosteroids,
cov thyroid hormones
sympathomimetics
tshuaj tiv thaiv qhov ncauj
phenothiazine derivatives,
nicotinic acid.

Cimetidine qeeb kev tshem tawm ntawm cov tshuaj metformin los ntawm lub cev thiab tuaj yeem ua rau lactic acidosis.

Merifatin nws tus kheej attenuates cov nyhuv ntawm coumarin derivatives.

Thaum sau tshuaj kho nrog tus neeg sawv cev no, tus kws kho mob uas koom nrog yuav tsum paub txog kev haus cov tshuaj saum toj no.

Cov lus qhia tshwj xeeb

Lub sijhawm kho mob, nws yog ib qho tseem ceeb los saib xyuas qhov mob ntawm ob lub raum. Yog tias muaj kev txawv txav ntawm kev ua txhaum lawv txoj haujlwm, kev txais tos ntawm cov cuab yeej no tau muab tso tseg.

Metformin nws tus kheej tsis cuam tshuam rau lub peev xwm ntawm kev tsav tsheb, txawm li cas los xij, kev sib xyaw nrog insulin lossis sulfonylurea, muaj qhov tshwm sim zoo li no. Yog li ntawd, nrog kev kho ua ke, koj yuav tsum tsis kam tsav lub tsheb thiab ua haujlwm nrog cov txheej txheem nyuaj.

Cawv kuj tseem tuaj yeem ua rau lactic acidosis, yog li noj nws yog qhov tsis xav ua.

Hauv kev phais mob uas yuav tuaj tom ntej, thaum kho cov mob, kev raug mob hnyav, ua rau qaug tus mob mus ntev, cov tshuaj yuav tsis siv.

Tus neeg mob yuav tsum paub cov tsos mob ntawm kev phiv, hypoglycemia thiab lactic acidosis thiab muaj peev xwm muab kev pabcuam ua ntej.

Cov tshuaj tsis muaj carcinogens.

Tseem Ceeb! Cov tshuaj yuav muab faib tawm los ntawm cov tshuaj noj!

Txais tos thaum laus

Metformin-based ntsiav tshuaj yog siv rau hauv kev kho mob ntawm cov neeg laus, tab sis nrog kev ceev faj, vim tias lawv muaj kev pheej hmoo siab ntau ntawm kev mob ntshav qab zib ob leeg thiab lactic acidosis, tshwj xeeb tshaj yog thaum koom ua haujlwm hnyav lub cev. Cov pab pawg hnub nyoog no yuav tsum tau saib xyuas los ntawm tus kws kho mob tshwj xeeb thiab kev saib xyuas tas li ntawm qhov mob ntawm ob lub raum.

Cov lus thiab cov xwm txheej ntawm kev cia

Cov tshuaj yuav tsum muab khaws cia hauv qhov chaw tsaus thiab qhuav qhov chaw nkag rau cov menyuam yaus ntawm chav tsev kub. Lub sij hawm ntawm kev siv yog 2 xyoos txij li hnub pib. Tom qab ntawd cov ntsiav tshuaj pov tseg.

Cov cuab yeej no muaj ntau yam analogues. Nws yog ib qho siv tau los paub koj tus kheej nrog lawv piv cov khoom thiab cov ua tau zoo.

Bagomet. Cov tshuaj no yog cov sib txuam ua ke, suav nrog cov tshuaj uas muaj sia metformin thiab glibenclamide. Tsim los ntawm Chemist Montpellier, Argentina. Nws raug nqi los ntawm 160 rubles rau ib pob. Cov nyhuv ntawm cov tshuaj yog lub sijhawm ntev. Lub hnab looj hnab yog yooj yim siv thiab muaj nyob hauv chaw muag tshuaj. Nws muaj qauv contraindications.

Gliformin. Cov tshuaj no, uas suav nrog metformin, yog tsim los ntawm tuam txhab domestic Akrikhin. Tus nqi rau kev ntim khoom yog los ntawm 130 rubles (60 ntsiav tshuaj). Qhov no yog qhov piv txwv zoo ntawm cov tshuaj txawv teb chaws, tab sis raug txwv rau kev siv. Yog li, glyformin tuaj yeem siv tsis tau los tswj kev noj qab haus huv ntawm poj niam cev xeeb tub, menyuam yaus thiab cov laus. Txawm li cas los xij, muaj txiaj ntsig zoo tau sau tseg hauv kev kho mob ntshav qab zib feem ntau.

Metformin. Ib yam tshuaj uas ua tib yam muaj hauv cov hauv paus. Muaj ntau lub chaw tsim khoom: Gideon Richter, Hungary, Teva, Israel, Canonpharma thiab Ozone, Russia. Tus nqi rau kev ntim cov tshuaj yuav yog 120 rubles thiab ntau dua. Qhov no yog qhov pheej yig tshaj plaws ntawm Merifatin, pheej yig thiab txhim khu kev qha.

Ntsia hauv qab. Cov no yog cov ntsiav tshuaj uas muaj metformin hauv qhov muaj pes tsawg leeg. Chaw Tsim Tshuaj - Merck Sante lub tuam txhab hauv Fabkis. Tus nqi ntawm cov tshuaj yog 130 rubles thiab ntau dua. Qhov no yog duab txawv teb chaws ntawm Merifatin, muaj rau yuav khoom thiab luv nqi. Nws muaj ob qho tib si kev ncua sijhawm ntev thiab lub sijhawm ntev. Cov tshuaj tiv thaiv yog ib txwm: cov tshuaj yuav tsum tsis txhob muab rau cov menyuam yaus, poj niam cev xeeb tub thiab cov laus. Kev txheeb xyuas txog cov tshuaj muaj txiaj ntsig zoo.

Siofor. Cov ntsiav tshuaj no tseem ua raws metformin. Chaw Tsim Tshuaj - Cov tuam txhab German Berlin Chemie thiab Menarini. Tus nqi ntawm kev ntim khoom yuav yog 200 rubles. Muaj nyob ntawm kev nyiam thiab kev txiav txim. Nws qhov kev txiav txim yog nruab nrab hauv lub sijhawm, tuaj yeem siv nrog lwm cov tshuaj. Daim ntawv ntawm contraindications yog tus qauv.

Metfogamma. Cov tshuaj nquag ua haujlwm yog tib yam li hauv merifatin. Tsim los ntawm Werwag Pharm, Lub Tebchaws Yelemees. Muaj cov ntsiav tshuaj los ntawm 200 rubles. Qhov kev ua zoo sib xws, zoo li cov uas tau txwv hauv daim ntawv thov. Kev xaiv txawv teb chaws zoo thiab pheej yig.

Saib xyuas! Qhov kev hloov ntawm ib tus mus rau lwm qhov kev siv tshuaj hypoglycemic yog nqa tawm los ntawm kev saib xyuas ntawm kws kho mob. Kev siv tshuaj rau tus kheej yog txwv!

Feem ntau tshuaj xyuas ntawm merifatin yog qhov zoo. Kev ua hauj lwm zoo, muaj peev xwm coj nrog lwm cov tshuaj yog sau tseg. Raws li kev mob tshwm sim, cov neeg mob sau ntawv tias lawv tsuas yog thaum pib ntawm txoj kev kho, thaum lub cev tau siv tshuaj. Rau qee qhov, twj tsis haum.

Olga: “Kuv tau kuaj mob ntshav qab zib. Kuv tau kho nws ntev ntev, feem ntau siv tshuaj nrog tshuaj metformin hauv tshuaj muaj pes tsawg leeg. Kuv tsis ntev los no tau sim Merifatin txog kev qhia ntawm kuv tus kws kho mob. Kuv nyiam nws cov nyhuv ntev. Cov zoo yog tsis txaus siab. Thiab hauv tsev muag tshuaj nws ib txwm yog. Yog li nws yog ib qho cuab yeej zoo. "

Valery: “Kuv muaj mob ntshav qab zib mob los ntawm kev rog dhau. Yam kuv tau sim, ua los ntawm kev noj haus tsis pab. Tus kws kho mob sau npe rau Merifatin, sau tseg tias nws yuav tsum pab txo qhov hnyav. Thiab nws hais yog lawm. Kuv tsis tsuas yog khaws cia qab zib tam sim no, tab sis kuv tau poob peb phaus ib hlis twg. Rau kuv, qhov no yog kev kawm tau. Yog li kuv pom zoo nws. ”

Dosage daim ntawv

oblong biconvex ntsiav tshuaj, zaj duab xis-coated dawb nrog kev pheej hmoo ntawm ib sab. Hauv seem hla, qhov tseem ceeb yog dawb lossis yuav luag dawb.

1 ntsiav tshuaj muaj:

Tus nquag siv tshuaj ua haujlwm: metformin hydrochloride 1000 mg.

Cov neeg siv: hypromellose 2208 10.0 mg, povidone K90 (collidone 90F) 40.0 mg, sodium stearyl fumarate 10.0 mg.

Cov dej ua kua xim zaj duab xis zaj duab xis: hypromellose 2910 14.0 mg, polyethylene glycol 6000 (macrogol 6000) 1.8 mg, polysorbate 80 (kaum 80) 0.2 mg, titanium dioxide 4.0 mg.

Cov Tshuaj Hauv Tshuaj

Sab sij huam

Cov zaus ntawm cov kev mob tshwm sim ntawm cov tshuaj yog kwv yees li nram no: ntau zaus (≥1 / 10), feem ntau (≥1 / 100, 35 kg / m2,

- keeb kwm mob ntshav qab zib hauv plab ntu,

- tsev neeg muaj keeb kwm mob ntshav qab zib hauv cov neeg txheeb ze thawj qib,

- ntxiv concentration ntawm triglycerides,

- txo cov roj HDL cov roj (cholesterol),

Muaj feem cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov twj:

Kev kho mob monotherapy nrog metformin tsis ua rau mob ntshav qab zib thiab yog li tsis muaj kev cuam tshuam lub peev xwm ntawm kev tsav tsheb thiab cov txheej txheem. Txawm li cas los xij, cov neeg mob yuav tsum ceev faj txog kev pheej hmoo ntawm kev mob ntshav qab zib thaum siv cov metformin hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic (sulfonylurea derivatives, insulin, repaglinide, thiab lwm yam).

Hom 2 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog rau cov neeg mob rog rog, nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab ua si lub cev:

- hauv cov neeg laus, raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg lub qhov ncauj hypoglycemic lossis los nrog insulin,

- hauv cov menyuam yaus txij li 10 xyoo los ua kev kho mob lossis siv tshuaj insulin. Kev tiv thaiv tus kab mob ntshav qab zib hom 2 hauv cov neeg mob uas muaj ntshav qab zib nrog rau lwm qhov kev pheej hmoo los tsim tus mob ntshav qab zib hom 2, uas kev hloov pauv hauv lub neej tsis tso cai rau kev tswj ntshav ua kom tiav.

Cov tshuaj Merifatin: cov lus qhia rau kev siv

Txhawm rau cov theem ntawm cov piam thaj hauv cov ntshav, cov tshuaj sib txawv yog siv, uas suav nrog Merifatin. Kev siv tshuaj hypoglycemic muaj contraindications thiab phiv, yog li ua ntej pib kev kho mob, koj yuav tsum mus ntsib tus kws kho mob tshwj xeeb thiab kawm cov lus qhia.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj muaj nyob hauv daim ntawv ntawm 500 ntsiav tshuaj, 850 mg thiab 1000 mg, txheej. Lawv muab tso rau hauv 10 daim. rau hauv lub hlwv. Ib daim npav cardboard tej zaum yuav muaj 1, 2, 3, 4, 5, 6, 8, 9, lossis 10 lub hlwv. Cov ntsiav tshuaj muaj peev xwm muab tso rau hauv lub thawv polymer ntawm 15 pcs., 30 pcs., 60 pcs., 100 pcs. lossis 120 pcs. Tus nquag ua hauj lwm yog metformin hydrochloride. Ntu cov khoom siv yog povidone, hypromellose thiab sodium stearyl fumarate. Cov dej-soluble film zaj duab xis muaj polyethylene glycol, titanium dioxide, hypromellose thiab polysorbate 80.

Nrog saib xyuas

Lawv ua tib zoo noj tshuaj thaum lub sijhawm phais mob ntau thiab raug mob thaum tsim nyog yuav tsum tau siv tshuaj insulin, cev xeeb tub, kev haus dej cawv ntev lossis mob dej cawv sai, ua raws li cov zaub mov tsis muaj calorie, lactic acidosis, zoo li ua ntej lossis tom qab xoo xaim radioisotope lossis xoo hluav taws xob, thaum lub sijhawm muaj tshuaj tiv thaiv iodine uas muaj tshuaj rau tus neeg mob Cov.

Thaum cev xeeb tub, Merifatin yuav tsum noj nrog kev saib xyuas zoo.

Yuav noj Merifatin li cas?

Cov khoom lag luam yog npaj rau kev siv qhov ncauj. Thawj koob tshuaj thaum lub sij hawm monotherapy rau hauv cov neeg laus cov neeg mob yog 500 mg 1-3 zaug ib hnub. Qhov koob tshuaj tuaj yeem hloov mus rau 850 mg 1-2 zaug ib hnub. Yog tias tsim nyog, cov koob tshuaj tau nce mus txog 3000 mg rau 7 hnub.

Cov menyuam yaus hnub nyoog tshaj 10 xyoo raug tso cai noj 500 mg lossis 850 mg ib hnub ib zaug lossis 500 mg 2 zaug ib hnub. Cov koob tshuaj muaj peev xwm nce ntxiv hauv ib lis piam mus rau 2 g ib hnub rau 2-3 koob. Tom qab 14 hnub, tus kws kho mob kho cov tshuaj noj ntau npaum li cas, suav nrog cov ntshav qab zib hauv cov ntshav.

Thaum ua ke nrog cov tshuaj insulin, qhov tshuaj ntawm Merifatin yog 500-850 mg 2-3 zaug ib hnub.

Lub plab zom mov

Los ntawm cov hauv plab zom mov, xeev siab, ntuav, raws plab, mob plab thiab tsis qab los noj mov yog cai. Cov tsos mob tsis zoo txaus siab tshwm sim ntawm thawj theem ntawm kev kho mob thiab ploj mus rau yav tom ntej. Txhawm rau kom tsis txhob sib tsoo nrog lawv, nws yog ib qho tsim nyog yuav tsum pib nrog qhov tsawg kawg kev noj tshuaj thiab maj mam nce nws.

Kev cuam tshuam nrog lwm yam tshuaj

Nws yog txwv tsis pub txuas cov tshuaj metformin nrog iodine-muaj cov tshuaj radiopaque. Nrog ceev faj, lawv noj cov tshuaj Merifatin nrog Danazole, Chlorpromazine, glucocorticosteroids, diuretics, txhaj tshuaj beta2-adrenergic agonists thiab antihypertensive cov neeg sawv cev, tshwj tsis yog rau inhibitors ntawm agiotensin hloov enzyme.

Ib qho kev nce ntxiv ntawm cov tshuaj metformin hauv cov ntshav tau pom thaum lub sijhawm cuam tshuam nrog cov tshuaj cationic, cov uas amiloride. Kev nqus ntawm metformin ntau ntxiv tshwm sim thaum ua ke nrog nifedipine. Hormonal contraceptives txo cov nyhuv hypoglycemic ntawm cov tshuaj.

Cawv tau zoo

Thaum kho lub sijhawm, nws yog txwv tsis pub haus dej cawv thiab cov khoom lag luam uas muaj ethanol, vim qhov pheej hmoo ntawm cov kab mob lactic acidosis.

Yog tias tsim nyog, siv cov tshuaj zoo sib xws: