Cov tshuaj Diroton nrog qhov ntau npaum ntawm 2.5 mg tau muag hauv aluminium / PVC blisters ntawm 14 ntsiav tshuaj, feem ntau 1 lossis 2 lub hlwv nyob hauv ib pob.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm 5 mg / 10 mg / 20 mg kuj tseem muag hauv aluminium / PVC blister ntim ntawm 14 ntsiav tshuaj, feem ntau 1, 2 lossis 4 blisters nyob rau hauv ib pob.

Pharmacodynamics thiab pharmacokinetics

Diroton (INN: Lisinopril) tau suav hais tias yog ib qho inhibitor ntawm angiotensin-hloov chaw, yuav cuam tshuam cov saw tsim los ntawm angiotensin II - hauv Kuv. Lisinopriltxo cov qib ntawm vasoconstrictor nyhuv ntawm lub cev - angiotensin IIhos lub siab aldosterone hauv cov hlab ntsha poob qis.

Lisinoprilpab txo qhov ntim ntawm atrial tsis kam. Cov tshuaj Diroton, nws siv los txo cov ntshav siab, tsis cuam tshuam lub plawv dhia (lub plawv dhia) thiab ua rau muaj kev nce ntshav ntau feeb, ntxiv rau lub raum khiav ntshav. Txhawm rau kom ua tiav qhov siab tshaj plaws, nws yuav siv 6 teev sijhawm yav tom ntej, nws mob tsawv ntev li ib hnub thiab tuaj yeem hloov pauv nyob ntawm seb ntau npaum li cas ntawm cov tshuaj. Diroton los ntawm kev kub siab nrog kev siv lub sijhawm ntev txo nws cov haujlwm.

Cov Ntaub Ntawv Pharmacokinetics

Txheej txheem nqus tau los ntawm cov hnyuv, ces lisinoprilkev mus rau hauv cov ntshav ntshav tsis khi rau cov nqaijrog. Feem ntau, cov neeg siv xyoob ntoo tsis ntau tshaj 25-30%, thiab kev noj haus tsis hloov pauv ntawm kev nqus. Cov tshuaj tawm tom qab 12 teev. Txij li thaum cov tshuaj nquag tsis hloov kho, nthuav tawm tsis hloov pauv nrog zis. Cov tshuaj Diroton tsis ua rau tus mob thim rov qab uas muaj qhov tsis kho.

Cov kev qhia rau kev siv Diroton

cov tshuaj muaj txiaj ntsig nyob hauv mob plawv tsis ua hauj lwm (raws li ib feem ntawm txoj kev kho ua ke),
yog tias xav tau kev tiv thaiv sab laug ventricular kawg, lub plawv tsis ua hauj lwmnrog rau kev txhawb nqa rau kev ua haujlwm ruaj khov hemodynamics — Diroton ntsiav tshuaj siv - los ntawm kev uas lawv ua tau zoo, suav nrog ntawm mob myocardial infarction,
ntawm uas mob ntshav qab zib nephropathy (txo qis albuminuria),
Cov kev qhia rau kev siv Diroton ntsiav tshuaj tseem muaj qhov tseem ceebthiab Renovascular arterial tawg(raws li monotherapy lossis kev sib txuas ua ke kho nrog lwm cov tshuaj tiv thaiv kabmob).

Cov Yuav Tsum Muaj

keeb kwm ntawv sau txog idiopathic angioedemasuav nrog kev siv ntau yam ACE inhibitors,
Quincke's edema caj dab,
cov menyuam hnub nyoog qis dua (≤ 18 xyoo),
poj niam cev xeeb tub thiab lactating,
paub txog kev hypersensitivity rau tam sim no lisinoprilulossis cov khoom siv pabcuam, nrog rau lwm yam ACE inhibitors.

Kev Tshuaj Kho Mob Diroton raug tshem tawm nrog ceev faj

nrog raum leeg mob stenosis los yog aortic orifice,
tom qab raum hloov ntshav,
cov neeg mob raum tsis ua haujlwm nrog CC tsawg dua 30 ml / min,
ntawm obstructive hypertrophic cardiomyopathy,
hauv thawj theem hyperaldosteronism,
ntawm arterial hypotension,
cov neeg mob uas muaj cov kab mob cerebrovascular lossis cerebrovascular tsis txaus,
cov foos hnyav mob ntshav qab zib mellitus,
ntawm scleroderma, Ischemic mob plawv, mauj lupus erythematosus,
mob plawv tsis ua hauj lwm ntev,
cov neeg mob uas tsim txom mob hlwb pob txha hematopoiesis,
hauv hypovolemicmobntawm tshuaj mob siab ntsws,
cov neeg laus laus
cov neeg nyob rau hemodialysiskev puas txaus lim ntshav qias tuaj (AN69)li sai tau anaphylactic cov tshuaj tiv thaiv.

Sab sij huam

Cov tshuaj siab no tuaj yeem ua rau cov kev xav tsis zoo xws li kiv taub hau thiab mob taub hau (nyob ntawm thaj tsam ntawm 5-6% ntawm cov neeg mob), muaj peev xwm ua kom tsis muaj zog, zawv plab, ua pob rau ntawm daim tawv nqaij, xeev siab, ntuav, hnoos qhuav (hauv 3%), orthostatic hypotensionmob hauv siab (1-3%).

Lwm qhov kev mob tshwm sim nrog qhov kev tshwm sim uas tsawg dua 1% tuaj yeem muab sib faib rau cov nruab nrog khoom hauv nruab nrog cev uas lawv tshwm sim:

STS: ntshav siab qis, tachycardia, bradycardia, kev ua pov thawj ntawm lub plawv tsis ua haujlwm, ua haujlwm tsis pom kev ua haujlwm ntawm atrioventricular conduction, ua tau myocardial infarction.
Lub plab zom mov: kev tsis nco qablub qhov ncauj qhuav, kem plab, saj cov nyom, tsim pancreatitis, kab mob siab, dajntoo, hyperbilirubinemia, nce kev ua si ntawm daim siab enzymes - transaminases.
Daim tawv nqaij integument: urticariance tawm hws, photosensitization, alopeciakhaus tawv.
CNS: Kev hloov pauv sai sai hauv kev xav, kev tsis hnov qab, paresthesiaqaug zog thiab nkees nkees, tsis meej pem, txhawm ntawm ceg thiab daim di ncauj, asthenic mob ntsws.
Kev ua pa system: apnea, dyspnea, bronchospasm.
Hematopoietic system: neutropenia, leukopenia, thrombocytopenia, agranulocytosis, anemia.
Kev tiv thaiv kab mob: vasculitis, angioedemacov tshuaj tiv thaiv zoo (tshuaj ntsuam) rau Cov tshuaj tiv thaiv kev tawm tsam, nce ESR, eosinophilia.
Lub Hauv Paus Nruab Nrab: txo hauv potency, anusia, uremia, oliguria, lub raum khiav hauj lwm mus txog rau lub raum tsis ua hauj lwm.
Kev zom zaub mov: muaj ntau los yog tsawg cov poov tshuaj nyob rau hauv cov ntshav, txo qis ntawm sodium, magnesium, chlorine, nce concentration ntawm calcium, uric acid, urea, neeg tsim tswv, roj, hypertriglyceridemia.
Ntawm lwm tus: arthralgia, npaws, mob caj dab, myalgiakev txom nyem mob gout.

Nrog rau qhov tseem ceeb tawg

Txwv tsi pub coj mus uas lwm yam antihypertensive cov neeg sawv cev, tom qab ntawd cov nyiaj tso cai thawj zaug txhua hnub yuav tsum tsis pub tshaj 10 mg, txhawb nqa feem ntau nce txog 20 mg. Tom qab kev tshawb nrhiav BP puab nws tuaj yeem raug nce ntxiv mus txog qhov siab tshaj 40 mg, coj mus rau hauv tus account tias kev txhim kho tag nrho ntawm cov nyhuv yog pom ntawm 2-4 lub lis piam. Yog hais tias tus neeg mob tsis muaj suab hais txog kev kho mob, ces kev kho mob ntxiv nrog rau lwm qhov antihypertensive siv yeeb siv tshuaj.

Saib xyuas! Ua ntej noj Diroton, nws yog ib qho tsim nyog kom thim txoj kev khotshuaj kho mob nyob rau hauv txog 2-3 hnub, txwv tsis pub thawj koob tshuaj Diroton yuav tsum tsis pub tshaj 5 mg / hnub. Txoj kev kho yog kwv nrog kev saib xyuas kev kho mob vim qhov txaus ntshai ntawm cov tsos mob arterial hypotension.

Thaum raug kho lub plawv tawg thiab lwm yam mob uas tshwm sim los ntawm cov kev ua haujlwm ntau ntxiv ntawm cov tshuaj tiv thaiv kab mob RAAS

Nws raug nquahu kom pib kho nrog kev siv tshuaj txhua hnub nyob rau thaj tsam ntawm 2.5-5 mg / hnub, zoo dua nyob rau hauv tsev kho mob uas muaj kev tswj hwm nruj, nrog rau kev saib xyuas HUAB TAISraum muaj nuj nqi, ntshiab poov tshuaj concentration. Tus saib xyuas koob tshuaj yog txiav txim siab raws li kev soj ntsuam ntawm puab ntawm cov ntshav siab.

Cov neeg mob raum tsis ua haujlwm

Ib qho tshuaj txhaj yuav tsum tau ua, uas yog txiav txim siab los ntawm kev ntsuam xyuas tsis tu ncua ntawm kev tshem tawm creatinine. Yog li nrog Cl ntawm 30-70 ml / min, kev kho mob pib nrog 5-10 mg lisinoprilib hnub, thaum 10-30 ml / feeb - 2.5-5 mg / hnub.

Pom zoo koob tshuaj ntawm cov neeg mob txhua hnub hemodialysisyuav tsum tsis pub ntau tshaj 2.5 mg.

Hauv lub plawv tsis ua haujlwm

Thawj koob tshuaj txhua hnub ntawm 2.5 mg tuaj yeem raug nce ntxiv tom qab 3-5 hnub mus rau kev saib xyuas tus qauv txij li 5 txog 20 mg. Yog tias tau thov yav tas los tshuaj kho mob, tom qab ntawd lawv cov koob tau raug txo kom tsawg kawg nkaus qhov tsim nyog. Kev kho mob yuav tsum pib nrog kev kawm thiab ua raws kev soj qab. HUAB TAIS, lub raum ua haujlwm, poov tshuaj thiab sodium ntau, uas yuav tiv thaiv txoj kev txhim kho arterial hypotensionraws li zoo li lub raum tsis ua haujlwm.

Cov lus qhia rau kev siv Diroton rau cov neeg mob tom qab mob myocardial infarction

Hauv thawj hnub tom qab kev paub txog myocardial infarction, tus neeg mob tau muab thawj koob tshuaj 5 mg, hauv koob thib 5 mg, rau koob thib ob ntawm 10 mg, txuas ntxiv kev kho mob nrog kev saib xyuas ib hnub ib zaug tsis ntau tshaj 10 mg rau 6 lub lis piam. Yog tias cov neeg mob muaj qis syst.AD, nws raug nquahu kom pib kho nrog koob tshuaj qis dua - 2.5 mg.

Cov Kev Kho Mob Ua Si

lub sijhawm teem tseg tshuab txais carbon,
pais plab lavage,
txhawb nqa Bcc(Xws li iv ntshav dlaws teeb meem),
mob kev kho mob
hemodialysis,
tshuaj xyuas cov haujlwm tseem ceeb heev.

Kev sib txuam

Ua txoj kev kho nrog ua ke nrog poov tshuaj-sparingtshuaj kho mob(piv txwv li, Spironolactone, Triamteren, Amiloride) thiab lwm yam tshuaj uas muaj cov poov tshuaj ntxiv yuav ua rau ntxim nyiam hyperkalemia.
Nrog sodium aurothiomalate tshwm sim cov tsos mob nyuabsuav nrog xeev ntuav, ntuav, yaugntsej muag thiab arterial hypotension.
β-blockers, qeeb Ca blockers, tshuaj kho mobthiab lwm tus antihypertensivespotentiate hypotensive nyhuv.
Nrog NSAIDssuav nrog xaiv COX inhibitors - 2, tshuaj estrogen, adrenomimetics antihypertensive nyhuv txo.
Nrog vasodilators, tricyclic cov tshuaj tiv thaiv kev ntxhov siab, barbiturates, phenothiazines, ethanol-muajhypotensive nyhuv yog tseem potentiated los ntawm txhais tau tias.
Nrog lithium npaj, kev maj mam poob hauv kev pom tshwm sim. lithium, uas ua kom zoo dua nws cov teebmeem cardiotoxic thiab neurotoxic.
Tshuaj Antacidsthiab Colestyraminetxo tus nqi ntawm kev nqus ntawm cov hnyuv.
Lisinoprilmuaj peev xwm txhim khu neurotoxicity dej qab ntsevtsis muaj zog cov nyhuv cov kab mob hypoglycemic, Epinephrine, Norepinephrine, gout tshuajtxhim kho cov teebmeem (suav nrog qhov tsis xav ua) mob glycosides, lub dag zogleeg ua kom mob, txo tus nqi ntawm kev tsis pom kev zoo Quinidine.
Txo qhov kev txiav txim tshuaj tiv thaiv qhov ncauj.
Nrog Methyldopance kev pheej hmoo ntawm hemolysis.

Thaum cev xeeb tub thiab lactation

Vim tias qhov tseeb tias tshuaj muaj peev xwm txeem rau hauv qhov chaw tiv thaiv hniav, muaj kev pheej hmoo ntawm tus me nyuam (II thiab III lub sijhawm):

pob txha taub hau hypoplasia,
hais tsawg HUAB TAIS,
hyperkalemia,
lub raum tsis ua hauj lwm
yog ua tau kev tuag — tus me nyuam tuag.

Raug Tawm Ntawm Cov Menyuam Mos ACE inhibitorsyuav tsum tau saib xyuas kev kho mob kom zoo vim qhov pheej hmoo txaus txos cov ntshav siab, hyperkalemia, oliguria.

Diroton cov lus piv txwv

Tus nqi ntawm Diroton analogues tsis hloov pauv - nyob rau thaj tsam ntawm 50-100 rubles. nyob ntawm cov naj npawb ntawm cov ntsiav tshuaj, lub teb chaws ntawm kev tsim khoom thiab lwm yam nqi nqe. Kev tshawb nrhiav yuav hloov li cas thiaj li hloov cov tshuaj tiv thaiv kabmob ntshav no yuav tsum yog ua raws li kev saib xyuas kev ua haujlwm ntawm cov ntshav siab thiab cov neeg lub cev muaj feem cuam tshuam rau lub cev, sab laj nrog koj tus kws kho mob. Muaj cov tshuaj uas txuam nrog cov tshuaj nquag, ntawm lawv muaj:

Aurolyza,
Vitopril,
Dapril,
Lysinocore.

Diroton Xyuas

Diroton feem ntau tau ua raws li kev pom zoo ntawm tus kws kho plawv thiab tom qab ob peb lub lis piam lawv tshaj tawm tias lawv xav zoo, dhau qhov tsis zoo nyob rau hauv lub siab, thiab ua pa zoo. Kev txheeb xyuas txog Diroton ntawm cov kab ntawv kuj tseem zoo, tab sis ntau tus hais tias koj xav tau tus kws kho mob zoo uas yuav pab koj xaiv qhov ntau npaum.

Pharmacological kev txiav txim

Diroton tau hais tawm hypotensive (txo qis ntshav siab) thiab peripherally vasodilating cov yam ntxwv.

Cov tshuaj qaug tshuaj ntawm cov tshuaj no yog lisinopril.

Tom qab daim ntawv thov, Diroton pib ua tom qab 60 feeb, qhov siab tshaj plaws pom tau tom qab 6-7 teev thiab tawm tsam txhua hnub.

Diroton. Cov lus qhia rau kev siv. Thaum dab tsi siab?

Cov tshuaj Diroton koom nrog cov pab pawg ntawm ACE inhibitors, lawv raug kho los ntawm cov kws kho plawv kom ua kom ntshav nce siab, hauv kev kho mob rau kev kho plawv thiab mob plawv.

Lub hauv paus tseem ceeb hauv cov tshuaj yog lisinopril. Nws tsis tsuas yog txo cov ntshav siab, tab sis txo txoj kev thauj khoom hauv cov hlab ntsha ntawm lub ntsws, nce tus nqi ntawm cov feeb ntim ntawm ncig ntshav.

Cov tshuaj yog tsim nyob rau hauv cov ntsiav tshuaj ntau npaum li cas - 2.5 - 20 mg. Rau cov neeg uas nyuam qhuav npaj noj D Iroton, cov lus qhia rau kev siv yuav qhia koj tias ntau npaum li cas, tab sis nws zoo dua tsis txhob coj koj tus kheej, tab sis sab laj nrog kws kho mob.

Ua ntej, cov laj thawj ntawm tus kab mob pathology raug txheeb xyuas, kev kuaj mob yog nqa tawm, tom qab ntawd tsuas yog kho kho kom tsim nyog xwb.

Cov tshuaj ua haujlwm li cas?

Hais txog ACE inhibitors, Diroton txo qhov ntxim nyiam ntawm kev hloov pauv ntawm angiotensin 2 tawm ntawm 1, vim tias cov khoom ntawm aldosterone tsawg zuj zus, thiab prostaglandins nce. Kev siv cov tshuaj tsis tu ncua muaj txiaj ntsig zoo rau kev mob ntawm myocardium, txo qis siab, thim cov hlab ntsha.

Hauv cov neeg mob uas muaj mob ua mob rau cov ntshav cev, cov tshuaj tseem ceeb rau cov ntshav ncig hauv lub myocardium. Raws li kev tshawb nrhiav, cov nyhuv ntawm Diroton tso cai ntev rau lub neej ntawm cov neeg mob plawv tsis ua haujlwm hauv qhov kev mob ntsws ntev. Hauv lub cev uas tau mob plawv, Diroton txo txoj kev txhim kho pathologies ntawm sab laug ventricle.

Txij lub sijhawm ntawm kev noj tshuaj, cov nyhuv ntawm cov tshuaj raug pom tom qab ib teev, thiab nws cov txiaj ntsig zoo tshaj plaws tshwm tom qab 6 teev thiab kav ib hnub. Tom qab ob peb lub hlis ntawm txoj kev kho, nws feem ntau yog ua tau kom tswj ntshav siab, tsis kam ntawm cov tshuaj tsis ua rau muaj mob tawm.

Rau leej twg Diroton koomhaum

Diroton ntsiav tshuaj tsuas yog siv tsis yog rau lub siab, tab sis rau ntau yam pathologies. Ntawm ib tug xov tooj ntawm pathologies, lub ntsiab tseem ceeb hauv kev kho mob ntawm cov tshuaj uas tau siv yog cov hauv qab no:

kub siab (qhov tseem ceeb, tus kho tshiab). Cov tshuaj no yog siv los kho mob lossis siv nrog lwm cov tshuaj,
mob plawv hauv cov mob hnyav. Cov ntsiav tshuaj yog kho los ntawm thawj hnub nrog kev ntseeg siab hemodynamics. Feem ntau, Diroton dhau los ua lub hauv paus ntawm kev sib koom ua ke nrog kev saib xyuas kev tiv thaiv kev ua haujlwm tsis zoo hauv cov hlab ntsws laug thiab lub plawv pathologies,
mob plawv tsis ua hauj lwm,
raum tsis ua haujlwm hauv ntshav qab zib. Cov tshuaj txo cov albuminuria hauv cov neeg muaj kev tiv thaiv insulin thiab kev txwv tsis pub tshaj li ib txwm muaj, hauv cov neeg mob ntshav siab tsis muaj insulin dependant.

Yuav ua li cas noj tshuaj siab

Ib ntsiav tshuaj ntawm Diroton ntawm cov tshuaj tsim nyog yog txaus ib hnub, nws raug nquahu kom haus cov tshuaj thaum sawv ntxov, ua ntej noj mov lossis tom qab - nws tsis muaj teeb meem. Thaum pib, 10 mg ntawm cov tshuaj yog kws kho, nyob rau hauv lub neej yav tom ntej, qhov ntau npaum yog maj maj coj mus rau 20 mg. Tom qab li 2-4 lub lim tiam ntawm kev siv tsis tu ncua, cov nyhuv siab ntawm cov tshuaj tau tiav.

Yog tias tus neeg mob tau noj cov tshuaj diuretics, 2 hnub ua ntej siv Diroton, lawv yuav tsum raug muab tso tseg. Yog tias qhov kev xaiv no yog qhov tsis nyiam, ces kev noj tshuaj ntawm Diroton yog txo rau 5 mg.

Yog tias kub siab yog ua rau muaj teeb meem los ntawm cov ntshav txaus rau lub raum, Diroton txoj kev kho yog pib nrog 2.5 mg, thiab tom qab ntawd tus nqi ntawm kev saib xyuas kho tau xaiv raws li kev nyeem ntawm lub tonometer. Thaum lub plawv tsis ua hauj lwm, cov tshuaj siab ua ke nrog cov tshuaj diuretics thiab digitalis tshuaj. Yog pom lub raum pathology, tus kws kho mob yuav siv sij hawm rau hauv kev txiav txim siab muab tshuaj ua ntej suav cov tshuaj ntau npaum li cas. Kev kho mob pib nrog 2.5-10 mg, thiab cov tshuaj kho kom zoo dua yog suav ua tus lej siab.

Thaum kho rau mob plawv sai, Diroton ntsiav tshuaj yuav dhau los ua ib qho kev sib koom ua ke. Nyob rau thawj hnub - 5 mg, tom qab ua hnub so thiab noj nws dua, tom qab ntawd 2 hnub - 10 mg ntawm cov tshuaj, tom qab ntawd - 10 mg txhua hnub. Thaum kho lub sijhawm, cov tshuaj tshwm sim hauv 1.5 lub hlis.

Thaum tsis tshua muaj systolic lub siab, kws kho plawv tawm tshuaj 2,5 mg ntawm Diroton, tab sis yog tias, tom qab lub sijhawm tswj tau dhau mus, lub siab tseem qis, tom qab ntawd cov ntsiav tshuaj yuav tsum tau txiav tawm.

Cov lus qhia siv thiab ntau npaum li cas

Cov tshuaj yog npaj rau cov thawj coj hauv qhov ncauj ib hnub ib zaug tib lub sijhawm, tsis hais txog ntawm cov zaub mov noj.

Rau kev kho mob ntawm kev mob ntshav siab, tus neeg mob tau xaj 10 mg ntawm cov tshuaj. Kev saib xyuas txhua hnub koob, raws li txoj cai, tsis pub tshaj 20 mg, tab sis qhov siab tshaj plaws tau tso cai - 40 mg.

Kev kho mob tag nrho tshwm sim 3-4 lub lis piam tom qab pib ntawm kev kho mob, uas yuav tsum tau coj mus rau hauv tus account thaum nce ntxiv qhov ntau npaum. Nws tseem tuaj yeem ua ke Diroton nrog lwm cov tshuaj tiv thaiv kabmob.

Yog tias tus neeg mob tau txais kev kho mob yav dhau los nrog cov tshuaj diuretics, lawv cov thawj coj yuav tsum tau nres 3-4 hnub ua ntej pib kho nrog Diroton. Yog tias nws tsis tuaj yeem tshem tawm cov tshuaj diuretics, qhov pib txhaj tshuaj yuav tsum tsis pub tshaj 5 mg rau ib hnub. Tom qab noj thawj koob, koj yuav tsum nyob hauv kev saib xyuas kev noj qab haus huv rau 1-2 teev, txij li thaum nce ntshav tuaj yeem tshwm sim.

Thaum muaj kev hloov kho cov ntshav siab thiab lwm yam mob nrog rau kev ua haujlwm ntawm renin-angiotensin-aldosterone system, kev pib txhaj tshuaj ntawm 2,5-5 mg ib hnub twg yog tsim nyog.

Hauv kev mob ntsws thiab mob plawv tsis zoo, raws li cov lus qhia rau Diroton, thawj koob yuav tsum tau sib npaug ntawm 2.5 mg, uas yuav tsum maj mam nce mus rau 5-20 mg. Thaum kho cov tshuaj, nws yog ib qho tsim nyog los saib xyuas lub raum kev ua haujlwm, ntshav siab, sodium thiab potassium nyob rau hauv cov ntshav.

Hauv qhov mob myocardial infarction hauv thawj ob hnub, 5 mg Diroton yog tus kws kho mob. Tom qab kev saib xyuas cov tshuaj yuav tsum tsis pub ntau tshaj 10 mg. Lub sijhawm kho yog tsawg kawg 6 lub lis piam.

Hauv kev mob ntshav qab zib nephropathy hauv cov neeg muaj ntshav qab zib insulin-tiv thaiv mob ntshav qab zib mellitus, cov tshuaj no tau sau tseg ntawm 10 mg rau ib hnub twg. Yog tias tsim nyog, qhov koob tshuaj yuav raug nce ntxiv rau 20 mg.

Phiv los ntawm Diroton

Cov lus qhia rau Diroton tau sau tseg tias cov tshuaj yuav ua rau muaj ntau cov kev mob tshwm sim los ntawm tus neeg mob lub cev:

Lub plawv mob: txo cov ntshav siab, mob hauv siab, tachycardia, bradycardia, myocardial infarction,
Cov kab mob hauv lub cev: ntuav, qhov ncauj qhuav, mob plab, mob raws plab, tsis nco qab, txhawm rau txhawm rau, puas qab, saj tsis zoo, kab mob siab, mob daj ntseg, daj ntseg, daj ntseg, hyperbilirubinemia,
Daim tawv nqaij: nce tawm hws, urticaria, photosensitivity, plaub hau poob, khaus,
Nruab nrab hauv lub paj hlwb: saib xyuas qhov tsis xis nyob, mus ob peb vas lab, sib txawv, nkees nkees, nkees nkees, ua xua,
Kab mob ntsws: hnoos qhuav, ua tsis taus pa, ua pa, hnoos qeev, bronchospasm,
Cov kab mob ntshav: thrombocytopenia, leukopenia, neutropenia, anemia, agranulocytosis, txo qis qis hauv hematocrit thiab hemoglobin,
Genitourinary system: oliguria, uremia, anuria, lub raum tsis ua haujlwm, txo qis libido thiab potency.

Cov yam ntxwv ntawm cov tshuaj

Ua ntej sau ntawv, lub crustacean yuav tsum ua kom tus neeg mob lub siab yog tias nws cuam tshuam los ntawm diuretics, ntsev qis hauv zaub mov, raws plab lossis ntuav. Tus kws kho mob yuav tsum tswj hwm cov ntsev hauv cov neeg mob lub cev, nce nws yog tias tsim nyog, thiab rov qab tswj dej kom sib npaug.

Nrog rau kev teem sijhawm ntawm Lisinopril tom qab kev phais mob hnyav lossis cov tshuaj muaj zog uas txo cov ntshav siab, ib qho kev poob siab ntau yuav tshwm sim. Nws yog ib qho tseem ceeb rau kev soj ntsuam ntshav suav hauv chav kuaj mob, vim tias lub siab tsis ua haujlwm nrog lub raum tsis ua haujlwm kuj tuaj yeem ua rau lub siab poob ntau dhau. Thaum lub plab tsis zoo ua haujlwm, Kev kho mob Diroton yog nqa los ntawm kev saib xyuas ntawm tus kws kho mob, muab ntau npaum li cas tau ua tib zoo suav.

Kev sib xyaw Diroton thiab haus cawv tsis pom zoo, txij li thaum ethanol ua rau lub zog hloov qis dua cov nyhuv. Tshwj xeeb yuav tsum ceev faj thaum lub cev ua si, hauv huab cua sov, txij li lub cev qhuav dej ntau ntxiv hauv cov xwm txheej zoo li no, thiab lub siab tuaj yeem poob rau theem txaus ntshai.

Yog tias kiv taub hau tshwm sim lossis qhov tshwm sim txo qis thaum noj cov tshuaj, koj tsis tuaj yeem tsav lub tsheb, thiab tsis tuaj yeem ua haujlwm uas yuav tsum tau saib xyuas.

Cov chaw muag tshuaj

Angiotensin-hloov mus rau enzyme lossis ACE yog lub hauv paus rau kev hloov pauv ntawm angiotensin I mus rau angiotensin II. Lub enzyme angiotensin II ua rau cov kua roj ntsha ntawm aldosterone tso tawm, hauv qab nws qhov kev txiav txim siab muaj qhov nqaim ntawm cov hlab ntshav thiab nce ntshav siab. ACE tshuaj cuam tshuam rau renin-angiotensin system, tiv thaiv kev nce hauv aldosterone ntau, yog li thaiv qhov mechanism ntawm kev ua kom lub suab vascular.

Diroton cuam tshuam ncaj qha rau cov txheej txheem ntawm kev loj hlob ntawm kev kub siab, thiab tsis yog nyob ntawm qhov tshwm sim ntawm tus kab mob - ntshav siab. Kev haus cov tshuaj tsis tu ncua tiv thaiv kev ua kom tsis txhob muaj zog thiab tiv thaiv kom tsis txhob tawg.

txos cov ntshav siab
muaj kev mloog ntxiv ntawm cov poov tshuaj hauv cov ntshav,
kev tiv thaiv kev siab surges,
txhim kho lub raum ua haujlwm
txo cov thauj khoom ntawm lub myocardium.

Qhov kev kub siab ntawm cov tshuaj nquag hauv lub cev maj mam nce ntxiv hauv 7 teev tom qab noj tshuaj. Cov tshuaj yog xyaum tsis metabolized. Tom qab txog 12-13 teev, ib feem tseem ceeb ntawm cov tshuaj nquag raug nthuav tawm tsis hloov pauv ntawm cov zis. Hauv qhov no, qhov kev txo qis ntawm cov ntsiab lus tseem ceeb hauv cov ntshav plasma tshwm sim maj mam, uas ua kom tsis muaj qhov ua kom zoo ntxiv, thiab tib lub sijhawm tsis ua rau kom muaj lub zog ntse ntxiv thaum kawg ntawm kev ua ntawm lisinopril.

Tsuas noj cov caij nyoog thiab cov tshuaj noj

Diroton ntsiav tshuaj yuav tsum tau noj ib zaug ib hnub, tib lub sijhawm. Qhov no yuav ua kom paub tseeb tias muaj kev cuam tshuam ntawm cov tshuaj yam tsis muaj kev hloov pauv hauv kev txiav txim siab ntawm cov tshuaj nquag hauv cov ntshav cov ntshav. Yuav ua li cas noj Diroton - nws nyob ntawm tus pov thawj.

Nrog rau kev kub siab, kev kho mob pib nrog 10 mg ntawm Diroton rau ntau lub lis piam. Lub sijhawm thaum ntxov, koj yuav tsum tau npaj rau qhov txo qis ntawm cov ntshav siab thiab cov tsos mob ntawm cov tsos mob ntawm hypotension. Tom qab ob peb lub lis piam, nws yog ib qho tsim nyog kom yauv mus soj ntsuam kom ntsuas qhov ua tau zoo ntawm cov tshuaj. Ntawm kev pom zoo ntawm tus kws kho mob, kev coj ntxiv rau kev siv tshuaj tuaj yeem hloov tau ob qho tib si nyob rau hauv kev coj ua kom nce lossis txo qis kev pom zoo ntau npaum li cas. Qhov siab tshaj plaws niaj hnub noj tshuaj rau cov roj ntsha txog hlab ntsha yog 80 mg ntawm lisinopril.
Hauv lub plawv tsis ua hauj lwm, cov tshuaj yog kws kho ntxiv rau kev noj tshuaj diuretics. Qhov tshuaj thawj zaug yog 2.5 mg (ib nrab ib ntsiav tshuaj ntawm Diroton 5 mg). Tom qab ob lub lis piam, qhov tshuaj tau nce ntxiv mus rau 5 mg, tom qab ntxiv 14 hnub - txog 10 mg ntawm lisinopril.
Hauv kev kho mob ntawm cov mob myocardial infarction, kev tswj hwm ntawm lisinopril yog xyaum, tab sis qee kis, Diroton ntsiav tshuaj yog cov kws kho mob. Thawj hnub, koj yuav tsum noj 5 mg ntawm tshuaj, rau hnub thib ob thiab tom qab ntawd - 10 mg ntawm cov tshuaj. Yog tias tus neeg mob ntshav muaj ntshav tsawg nyob hauv thawj ob peb hnub tom qab lub plawv nres, 2.5 mg ntawm Diroton raug pom zoo. Peb hnub tom qab lub plawv nres, lawv hloov mus rau qhov kev noj tshuaj ib hnub twg (10 mg) ntawm Diroton ib hnub. Kev kho mob yuav siv 4-6 lub lis piam.
Hauv kev kho mob ntshav qab zib nephropathy, Diroton tau noj nyob ntawm 10 mg rau ib hnub twg rau thawj ob peb lub lis piam, tom qab ntawd nce ntxiv qhov tshuaj rau 20 mg.

Capsules thiab ntsiav tshuaj Diroton yuav tsum tau noj tsis hais noj zaub mov, muaj dej txaus. Kev txais tos yog zoo tshaj plaws thaum sawv ntxov. Diroton tuaj yeem raug tshuaj rau cov neeg laus neeg mob. Cov koob tshuaj pauv hauv qhov no tsis tas yuav tshwj tsis yog tus kws kho mob txiav txim lwm yam.

Txiag tej menyuam

Qhov ntau thiab tsawg ntawm cov tshuaj rau cov menyuam yog muab los ntawm tus kws kho mob ib leeg zuj zus

Diroton yog siv rau hauv kev xyaum tsiaj txhu. Cov tshuaj yog tawm rau cov menyuam yaus uas muaj ntshav siab tshaj 6 xyoo. Yog tias tus menyuam qhov hnyav tshaj 20 kg, 2.5 mg ntawm kev siv tshuaj rau ib hnub yog tau sau tseg, uas sib npaug ib nrab ntawm ib ntsiav tshuaj tsawg kawg ntawm 5 mg.

Ob peb lub lis piam tom qab pib noj tshuaj, tus kws kho mob yuav muab ob npaug koob tshuaj yog tias tus neeg mob zam Diroton txoj kev kho zoo.

Txais tos thaum cev xeeb tub thiab lactation

Diroton, kev siv ntawm uas yog nqa tawm raws li cov lus qhia, txwv tsis pub noj thaum cev xeeb tub. Cov ntaub ntawv kom raug ntawm cov nyhuv ntawm cov tshuaj rau ntawm kev txhim kho cev xeeb tub thiab menyuam hauv plab tsis muaj. Yog tias cev xeeb tub tau tshwm sim thaum Diroton therapy, kev siv tshuaj yuav tsum tsis ua ntxiv.

Cov poj niam npaj ua cev xeeb tub yuav tsum tsis txhob noj cov tshuaj. Diroton txoj kev kho yuav tsum tau muab pov tseg tsawg kawg peb lub hlis ua ntej qhov kev xav ntawd.

Thaum lub sij hawm lactation, noj cov tshuaj yog txwv tsis pub. Yog tias tsim nyog kho, kev pub mis niam yuav tsum tsis ua mus ntxiv.

Tshaj tsos mob

Nrog cov tsos mob ntawm kev noj tshuaj ntau dhau, tam sim ntawd yaug lub plab koj tus kheej

Cov neeg mob hauv cov tshuaj hnyav tsis tau sau tseg, yog li tsis muaj cov ntaub ntawv raug ntawm cov tsos mob tshwm sim. Txawm li cas los, kev noj cov ntau ntawm cov tshuaj yuav ua rau:

lub zog txo rau hauv siab,
lub raum tsis ua hauj lwm
tachycardia
bradycardia
ua txhaum ntawm cov dej-electrolyte tshuav.

Yog tias koj xav tias noj tshuaj ntau dhau, ua rau yaug koj lub plab tam sim ntawd thiab ua rau ntuav. Tom ntej no, kev kho cov tsos mob yog nqa tawm, yog li nws yog qhov yuav tsum tau hu rau lub tsheb thauj neeg mob hauv tsev.

Cov lus qhia tshwj xeeb

Diroton nrog kub siab los ntawm qhov siab yuav tsum tau noj tsuas yog qhia los ntawm kws kho mob. Txhawm rau kom tsis txhob muaj qhov pib ntawm cov tsos mob ntawm kev mob siab, koj yuav tsum tso tseg lwm yam tshuaj, pib noj tshuaj Diroton. Qhov no yog qhov tseeb tshwj xeeb tshaj yog cov tshuaj diuretics, txij li kev sib koom tes ntawm cov tshuaj no nrog ACE inhibitors thaum pib kho yuav ua rau muaj kev cuam tshuam hauv lub siab ceev ceev.

Hauv cov neeg mob uas mob ntshav siab tsis txaus, cov tsos mob ntawm lub siab tsis tshua pom los ntawm kev pib noj Diroton. Txoj kev pheej hmoo ntawm qhov txo qis hauv siab nce nyob rau hauv lub xub ntiag ntawm cov teeb meem ntawm kub siab.

Yog tias tus neeg mob tau muaj kev pheej hmoo ntxiv ntawm kev txo cov ntshav siab rau cov txiaj ntsig tseem ceeb thaum noj tshuaj antihypertensive, nws raug nquahu kom pib kho nrog Diroton hauv kev siv tshuaj tsawg kawg nkaus.

Hauv cov neeg mob uas lub raum tsis ua haujlwm thiab mob ntshav qab zib mellitus, muaj kev pheej hmoo ntawm kev tsim hyperkalemia nrog kev siv cov tshuaj Diroton, yog li thaum lub sij hawm kho nrog cov tshuaj, koj yuav tsum ua ntu ua kev ntsuam xyuas kom paub txog qhov kev cuam tshuam no raws sijhawm.

Cov neeg mob ntshav qab zib yuav tsum ua tib zoo saib xyuas kev hloov pauv hauv cov ntshav qab zib hauv thawj lub hlis ntawm kev noj ib qho tshuaj tiv thaiv ntshav qab zib tshiab.

Yeeb tshuaj sib cuam tshuam

Kev siv cov tshuaj Diroton yuav tsum pom zoo nrog tus kws kho mob, vim tias qee cov tshuaj yuav cuam tshuam nrog kev txiav txim ntawm cov tshuaj antihypertensive. Hauv qhov no, koj yuav tsum qhia koj tus kws kho mob txog txhua yam tshuaj uas tus neeg mob noj nrog tas li.

Kev siv tshuaj ib txhij los tiv thaiv tshuaj tiv thaiv kab mob ntxiv kho qhov cuam tshuam ntawm cov tshuaj Diroton, uas tuaj yeem ua rau lub zog poob qis thiab cov tsos mob tshwm sim ntawm hypotension.
Thaum noj nrog aliskiren, txoj kev pheej hmoo ntawm kev tsim kev mob tshwm sim loj heev, yog li qhov sib xyaw no yog txwv.
Xws li kev kho mob ntshav siab, tshuaj diuretics yuav tsum tau muab thaum noj Diroton maj mam, vim tias muaj kev pheej hmoo ntawm kev txo qis hauv siab.
Kev siv yooj yim nrog cov tshuaj potassium-sparing diuretics ua rau muaj kev pheej hmoo ntawm hyperkalemia.
Cov nyhuv antihypertensive ntawm cov tshuaj Diroton poob qis thaum noj nws nrog cov tshuaj tsis-steroidal anti-inflammatory (acetylsalicylic acid, diclofenac, ibuprofen, thiab lwm yam).
Kev pom zoo siv Diroton nrog lithium npaj tsis tau pom zoo vim tias muaj tshuaj lom rau ntawm lub caij tom kawg.
Kev noj cov ntshav qab zib kom tsawg thaum lub caij Diroton txoj kev kho yuav ua rau muaj ntshav qab zib tsawg nyob hauv cov neeg mob ntshav qab zib mellitus.
Kev noj tshuaj sympathomimetics txo cov txiaj ntsig antihypertensive ntawm ACE inhibitor.
Nrog rau kev tswj hwm tib lub sij hawm nrog tricyclic cov tshuaj tiv thaiv kab mob los yog tshuaj loog, cov nyhuv hypotensive ntawm cov tshuaj rau cov ntshav nce siab.

Cov ncauj lus kom ntxaws qhia txog kev sib txuam nrog tshuaj tau muab hauv cov lus qhia raug rau kev siv.

Nqi thiab analogues

Qhov feem ntau siv thiab pheej yig Diroton hloov chaw

Nrog lub sijhawm ntev ntawm kev siv tshuaj, Diroton muaj txiaj ntsig ua lub luag haujlwm tseem ceeb. Tus nqi ntawm cov tshuaj sib txawv ntawm 300-700 rubles, thiab nyob ntawm seb qhov ntau thiab tsawg ntim. Yog li, ib hom tshuaj nyob rau hauv qhov ntau npaum ntawm 5 mg tus nqi 350 rubles rau 56 ntsiav tshuaj, hauv qhov ntau npaum ntawm 20 mg - 730 rubles rau tib pob.

Yog tias nws yog qhov tsim nyog los hloov cov tshuaj Diroton, cov tshuaj tiv thaiv analogues yuav tsum raug xaiv ntawm cov tshuaj nrog tib yam tshuaj muaj yees. Cov no suav nrog cov ntsiav tshuaj Vitopril, Irumed, Lizoril. Cov tshuaj pheej yig tshaj plaws yog Lisinopril ntawm kev lag luam hauv tsev. Tus nqi ntawm kev ntim cov ntim hauv qhov ntau npaum ntawm 20 mg tsuas yog 45 rubles rau 30 ntsiav tshuaj.

Kev tshuaj xyuas txog cov tshuaj

Yog tias tus kws kho mob sau Diroton, kev tshuaj xyuas tus neeg mob yuav pab ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj. Txij li cov tshuaj yog qhov nrov heev, ntau tus neeg yuav khoom txaus siab qhia lawv qhov kev xav thiab kev paub txog kev noj tshuaj.

"Nws tau siv Diroton rau ntau tshaj peb lub hlis txhawm rau txo cov ntshav siab tom qab yug me nyuam thib ob. Cov tshuaj tau los rau kuv, puas tau ua txoj haujlwm zoo nrog nws txoj haujlwm. Ntawm cov kev mob tshwm sim, Kuv tau ntsib tsuas yog xeev siab thiab kiv taub hau, uas tau ploj lawm li 3 hnub tom qab pib kho mob. "

“Tus kws kho mob tau hais Diroton ntev. Kuv coj hauv qhov ntau npaum ntawm 20 mg, tab sis cov kev mob tshwm sim tau pib, yog li cov koob tshuaj yuav tsum tau txo. Kuv tau haus cov tshuaj rau lub hlis thib ob - lub siab yog qhov ib txwm muaj, tsis muaj kev kub ntxhov thaum lub sijhawm no, feem ntau, kuv txoj kev xav tsuas zoo. "

“Diroton tau haus rau ob lub hlis, txhua yam mus zoo. Qee qhov nws tsis nyob hauv lub tsev muag tshuaj; Kuv yuav tsum tau noj ib qho tshuaj pleev ib qho rau 50 rubles. Los ntawm cov tshuaj pheej yig, phiv tawm tam sim ntawd tshwm sim - xeev siab, ua rau muaj zog txo qis, kiv taub hau, nce mus txog qhov tsis nco qab. Yog li ntawd, nws tau rov qab mus rau Diroton hauv ob peb hnub thiab tsis muaj kev phiv tshuaj. Kuv xav kom tsis txhob txuag koj txoj kev noj qab haus huv, vim tias nws tsis paub tias cov tshuaj ua pheej yig yog ua los. ”

Kev phiv tshuaj los ntawm Diroton

Muab tus naj npawb ntawm qhov tshwm sim tsis zoo uas Diroton tuaj yeem ua rau, koj yuav tsum tsis txhob muab tshuaj rau koj tus kheej. Cov kev mob tshwm sim hauv qab no yog qhia hauv cov lus qhia:

mob hauv pob tw, ib qho kev poob siab heev hauv lub siab, bradycardia, lub plawv nres,
pom kev ua xua ntawm daim tawv nqaij - urticaria thiab khaus, cov tsos mob ntawm hyperhidrosis, o ntawm lub ntsej muag thiab txhais tes / taw,
kev cuam tshuam ntawm txoj hnyuv hauv plab - mob plab, ntuav, raws plab. Kev yws ntawm lub qhov ncauj qhuav tau pom ntau zaus, qee zaum cov tsos mob ntawm tus kab mob siab thiab tus mob ua ke,
los ntawm cov kab mob ua pa - apnea, hnoos, mob hauv lub ntsws,
qhov chaw ntawm cov hlab hlwb mob nrog qhov txo qis ntawm kev saib xyuas, kev qaug zog ntau dhau los ntawm cov khoom ib txwm, tsis tsaug zog tsis nyob ntawm lub sijhawm. Kev ntshai dhau mus, tsaus muag,
cov tshuaj ua rau potency teeb meem, uremia, raum tsis ua haujlwm,
hauv kev kuaj ntshav, ib qho kev txo qis ntawm hemoglobin raug kuaj pom ntawm keeb kwm ntawm kev nce hauv ESR,
npaws.

Leej twg yuav tsum tsis txhob noj Diroton

Tsis yog txhua tus neeg mob tuaj yeem sau daim ntawv tshuaj no rau kev ntsuas siab. Muaj ntau tus lej sib kis uas tus kws kho mob yuav tau xaiv ntau hom tshuaj rau tus neeg mob.

ua xua rau kev sib xyaw ntawm cov tshuaj,
hloov raum tsis ntev los no
lub raum leeg mob stenosis,
lub raum tsis ua hauj lwm
muaj hnub nyoog me
cov biochemical ntshav tsis txaus suav, tshwj xeeb, cov poov tshuaj ntau dhau.

Cev xeeb tub thiab lactating tshuaj tsis tau sau tseg, tshwj tsis yog muaj mob yog thaum tus neeg mob lub neej muaj kev pheej hmoo.Tib yam siv rau kev pub niam mis - yog tias cov tshuaj siab xav tau, tus menyuam yuav pauv mus rau cov khoom siv sib tov.

Nrog kev ceev faj, Diroton yog qhov tsim nyog rau cov kev mob ntshav qab zib, 2-sided stenosis ntawm cov hlab ntsha ntawm lub raum, lub plawv tsis ua haujlwm hauv chav kawm ntev. Diroton yuav tsum tsis txhob noj nrog scleroderma thiab lupus erythematosus.

Txawm hais tias cov tshuaj pom zoo rau kev siv, nws yog ib qho tsim nyog yuav tsum ua tib zoo saib xyuas cov txheej txheem pom zoo los ntawm kws kho mob thiaj li tsis ua rau muaj kev cuam tshuam dhau. Cov tsos mob ntawm kev quav yeeb tshuaj yog raws li nram no:

electrolyte tshuav qhov tsis ua hauj lwm,
Circulatory poob siab
ib tug ntse poob nyob rau hauv siab,
hyperventilation ntawm lub ntsws
lub raum tsis ua hauj lwm
excruciating hnoos qhuav,
tachycardia thiab bradycardia,
ncaj tsis ntxhov siab
kiv taub hau.

Overdose yuav tsum tau kho cov tsos mob. Nws yog ib qho tsim nyog yuav tau hu rau lub tsheb tos neeg mob, yaug tus neeg mob lub plab, sau ntawv rau sorbents thiab chaw so. Nrog kev qaug cawv ntau dhau, kev kho mob hemodialysis yuav tsum tau ua.

Yog tias tus neeg mob tsis tuaj yeem siv Diroton, tus kws kho mob yuav xaiv cov tshuaj los ntawm lwm pab pawg uas muaj tib lub zog. Cov tshuaj tiv thaiv ze tshaj plaws yog hydrochlorothiazide, uas ua rau cov ntshav qis los ntawm kev nthuav tawm cov hlab ntsha. Lwm cov tshuaj uas tau txiav txim siab siv Diroton yuav yog: Dapril, Sinopril, Irumed.

Raws li kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob, Diroton theej nrog lub luag haujlwm. Kev phiv tshuaj, txawm tias lawv muaj pes tsawg tus, muaj tsawg. Feem ntau cov neeg mob tau ntsib kev tsis zoo nrog kev siv tshuaj ntau dhau.

Cov kws kho plawv nco ntsoov tias qhov tsis txaus ntshai tshwm sim nyob rau hauv lawv cov kev xyaum muaj nyob hauv daim ntawv ntawm ib tug neeg tsis kam txais ua cov tshuaj. Hauv cov xwm txheej zoo li no, txoj kev daws qhov teeb meem yog hloov cov tshuaj.

Feem ntau, Diroton copes zoo dua nrog txo qis siab hauv kev kho mob, vim tias ib cov tshuaj yeeb tshuaj tsis zoo li ntawd. Tus nqi pheej yig, uas haum rau cov neeg mob uas raug yuam kom noj tshuaj tiv thaiv kabmob ntev ntev.

Txhawm rau kom tsis txhob muaj qhov tsis zoo thiab tau txais kev pom zoo xwb, koj yuav tsum ua nws nruj me ntsis raws li kws kho mob tau hais tseg, soj ntsuam kev noj tshuaj thiab lwm yam kev pom zoo ntawm cov kws kho plawv txhawm rau kho qhov tseeb, kev ua neej, khoom noj khoom haus, thiab lwm yam.