Rosuvastatin: cov lus qhia rau kev siv, ceeb toom thiab tshuaj xyuas

Kev piav qhia cuam tshuam rau 18.07.2014

• Lub npe Latin: Rosuvastatin
• ATX Code: C10AA07
• Yam tshuaj muaj sia: Rosuvastatin (Rosuvastatin)
• Chaw tsim tshuaj paus: CANONPHARMA, Russia

Txhua lub ntsiav tshuaj yog xev txheej. Cov khoom tseem ceeb yog rosuvastatin.

• pob kws nplej siab
• magnesium stearate,
• microcrystalline cellulose,
• povidone
• calcium hydrogen phosphate dihydrate.

Muaj pes tsawg leeg zaj duab xis plhaub:

• selecate AQ-01032 liab,
• titanium dioxide
• hypromellose,
• macrogol-400,
• macrogol-6000.

Ua raws li cov koob tshuaj (10 mg, 20 mg, 40 mg), cov lus sib xyaw ntawm cov ntsiav tshuaj hloov pauv.

Kev ntsuas rau siv

Cov tshuaj Rosuvastatin yuav tsum tau ua:

• ntawm hypercholesterolemia (ntxiv rau kev noj haus ntxiv rau lwm qhov kev kho mob tsis muaj txiaj ntsig),
• ntawm hypertriglyceridemia (ntxiv rau kev noj haus ntxiv).

Cov Yuav Tsum Tau Ua

Cov tshuaj no yog contraindicated nyob rau hauv cov neeg uas muaj qhov siab me rau lub Cheebtsam ntawm cov tshuaj.

Tsis tas li, cov kab mob hauv qab no yog contraindications kom noj cov tshuaj qub:

Ntawm ntawm cev xeeb tub thiab pub niam mis Cov tshuaj yog tseem contraindicated.

Ceev faj yog qhia kom haus cov tshuaj no rau tib neeg nrog:

• sepsis,
• thaum cov kev pab cuam phais mob,
• ntawm kev cuam tshuam ntawm endocrine,
• nrog kev raug mob.

Koj tseem yuav tsum ceev faj txog kev siv Rosuvastatin mus rau cov neeg sawv cev ntawm cov haiv neeg Asian.

Rau cov neeg muaj hnub nyoog qis dua 18 xyoo thiab tom qab 65 xyoos, cov tshuaj no tsis raug pom zoo.

Sab sij huam

Cov tshuaj no muaj cov kev pom tshwm sim ntau yam uas tuaj yeem tshwm sim:

Musculoskeletal system:

Mob leeg:

Kab mob ua pa:

Cov kab mob zis:

• kis tau tus mob
• mob hauv qab plab.

Lub plab zom mov:

Lub plawv dhia:

Kev sib txuam

Tshuaj Antacids tuaj yeem noj tsuas yog tom qab qee lub sijhawm (txog 2 teev) tom qab noj cov tshuaj no, vim tias lawv siv ua rau qhov txo qis hauv kev ua kom muaj zog ntawm Rosuvastatin.

Erythromycin kuj yuav tsum tsis txhob noj nrog rosuvastatin, vim tias cov nyhuv ntawm cov tshuaj ua ke poob qis.

Pani Cov Tshuaj

Kev Kawm: Nws kawm tiav hauv Rivne State Basic Medical College nrog kev kawm tiav qib hauv Tshuaj. Nws kawm tiav hauv Vinnitsa State Medical University. M.I. Pirogov thiab ib qho kev xyaum ua haujlwm raws nws.

Kev: Los ntawm 2003 txog 2013, nws ua haujlwm ua tus kws muag tshuaj thiab yog tus thawj coj ntawm lub tsev muag tshuaj kiosk. Nws tau txais ntawv thiab cov kev sib txawv rau ntau xyoo ntawm consciousious kev ua haujlwm. Cov lus qhia txog cov ncauj lus kev kho mob tau raug luam tawm hauv cov ntawv tshaj tawm hauv zos (ntawv xov xwm) thiab ntawm ntau qhov Internet portals.

Rau cov uas lawv cov triglycerides tsis nce rau qib tseem ceeb, Kuv tsis qhia rosuvastine, muaj ntau qhov kev phiv, qhov kev ua si tsis tsim nyog rau cov tswm ciab, Kuv txiav txim los ntawm kuv tus kheej. Tam sim no kuv lees txais dibikor, feem ntau ob qho LDL thiab HDL, nws yog qhov ntau me me, tab sis kuj tseem muaj txiaj ntsig. Zoo, yog tias koj tseem tuaj yeem ua tsis tau yam tsis muaj statin, nws zoo dua rau txuas dibicor kom txo cov kev mob tshwm sim, tus kws kho mob tau qhia kuv li ntawd.

Kuv noj cov tshuaj tiv thaiv ntawm cov tshuaj no, nws yog hu ua Rosuvastatin-SZ. Tus kws kho plawv tau sau nws tawm sijhawm ntev, kom tiv thaiv lub plawv, nws kho nrog lub luag haujlwm kom txo cov roj (cholesterol) zoo, thiab nws txo qis ntawm 7.9 mus rau 5.5 tshaj ib nrab xyoo. Feem ntau lawv sau txog kev phiv, tab sis kuv tus kheej kuv tsis muaj dab tsi zoo li qhov no, kuv mloog zoo li qub.

Muaj pes tsawg leeg thiab noj ntau npaum

Rosuvastatin belongs rau cov lipid-txo cov tshuaj ntawm statin pawg. Subclass - HMG-CoA reductase inhibitors. Vim tias qhov kev txiav txim ntawm cov tshuaj pharmacological no, qhov tso siab ntawm lipids tsawg dua, qhov kev ua ntawm receptors rau LDL lwg me me yuav tsub kom muaj kev them nyiaj ntxiv, thiab vim li ntawd, lawv catabolize tau nrawm dua thiab raug tawm ntawm cov hlab ntshav. Tsis tas li ntawd, zoo li lwm cov statins, rosuvastatin muaj cov txiaj ntsig zoo ntawm endothelium, inhibiting nws qhov tsis ua hauj lwm (inhibits txoj kev txhim kho ntawm thaum ntxov atherosclerosis hauv preclinical theem), ntawm phab ntsa vascular (tiv thaiv nws los ntawm cov cholesterol teeb meem feem). Qhov tseem ceeb isoenzymemuab kev koom tes hauv cov metabolism rosuvastatin - CYP2C9

Daim ntawv tso tawm rosuvastatin yog cov ntsiav tshuaj. Lawv yog cov xim liab dawb hauv cov xim, convex ntawm ob sab, nrog ib zaj duab xis. Thaum lub txim, cov khoom puab yog nyob ze rau xim rau dawb. Lub ntsiab ua haujlwm tseem ceeb hauv cov ntsiav tshuaj - calcium rosuvastatin - muaj nyob hauv 5 mg, 10 mg thiab 20 mg. Nyob ntawm qhov ntau npaum li cas, daim ntawv ntawm cov ntsiav tshuaj txawv. Daim ntawv foos ntawm kev xaiv ntau npaum rau cov tshuaj nquag yog 5 mg thiab 20 mg, daim ntawv elongated yog 10 mg thiab 40 mg.

Hauv cov khw muag tshuaj, koj tuaj yeem yuav cov ntawv ntim nrog cov hlwv ntawm 6, 10, 14, 15 lossis 30 ntsiav tshuaj hauv txhua qhov, nyob ntawm seb qhov ntau npaum li cas, lossis 30 thiab 60 daim hauv cov thawv. Ntxiv rau cov khoom siv tseem ceeb (hauv qhov tseeb, rosuvastatin - lub npe ntawm cov npe thoob ntiaj teb), cov tshuaj muaj pes tsawg leeg suav nrog ntau yam tshuaj ntxiv: povidone, pob kws nplej siab, magnesium starate, microcrystalline cellulose. Cov lus sib xyaw ntawm lub plhaub suav nrog ib qho kev sib xyaw kom qhuav: talc, macrogol, titanium dioxide, hlau oxide (liab). Nyob ntawm tus tsim khoom, qhov sib xyaw no yuav txawv me ntsis.

Saum toj no, peb tau kuaj xyuas qhov muaj pes tsawg leeg ntawm tus thawj chaw tsim khoom rosuvastatin Canonpharma (lub teb chaws - Russia). Tsis tas li niaj hnub no peb yuav xav txog analogues ntawm cov tshuaj no raws li kev siv tshuaj radar (sau npe ntawm cov tshuaj), thiab txiav txim seb cov chaw tsim tshuaj nyob ntawm cov khw muag tshuaj muaj peev xwm zoo dua hauv nqe thiab zoo.

Sab sij huam

Yuav tsum yog cov kws kho mob pom zoo muab cov tshuaj txhua hnub, rosuvastatin ua rau muaj kev phiv ntau yam tsis tshua muaj mob. Txwv tsis pub, nrog kev kho mob tsis raug, cov tshuaj muaj peev xwm nqa tau ob qho txiaj ntsig thiab tsim kev puas tsuaj. Qhov tshwm sim ntawm cov kev mob tshwm sim yog txiav txim raws li WHO kev faib tawm (WHO): feem ntau, ntau zaus, qee zaum, cais cov xwm txheej, tsis tshua muaj, qhov tsis huv yog tsis paub. Tam sim no peb yuav txheeb xyuas qhov tseeb tias cov kev mob tshwm sim yog cov yam ntxwv thiab yuav tsum tau coj mus rau hauv cov tshuaj no.

• Humoral txoj cai cuam tshuam kev loj hlob: kev txhim kho cov tsis muaj insulin-mob ntshav qab zib mellitus (DM) hom 2.
• Kev tiv thaiv kab mob thiab tiv thaiv kab mob: tsis nco qab qhov ua haujlwm, tso zis, tso zis.
• CNS - mob mob taub hau, kiv taub hau.
• Mob pob txha thiab mob leeg - mob nqaij (myalgia), mob myopathy, rhabdomyolysis vim mob raum tsis ua haujlwm, hauv qee qhov mob tsawg (1 hauv 10,000 leej) - immuno-mediated necrotizing myopathy. Tsis tshua muaj - arthralgia, myositis. Nws yog ib qho tseem ceeb uas yuav tau saib xyuas qib theem ntawm kev ua si ntawm creatine phosphokinase enzyme thiab nrog qhov nce siab hauv kev nce siab (tsib zaug lossis ntau dua tus nqi no), kev kho mob nrog rosuvastatin tau muab tso tseg.
• Txoj hnyuv plab hnyuv plab hnyuv - mob plab, cem quav, xeev siab.
• Cov kab mob hauv lub raum - cov protein nyob hauv cov zis (proteinuria), feem ntau yog cov chaw regresses thaum kho thiab tsis yog qhov cim tseg ntawm qee qhov mob raum.
• Cov tawv nqaij thiab PUFA - khaus, urticaria, erythematous pob.
• Nplooj siab - koob tshuaj hloov pauv rau daim siab enzymes - transaminases thiab ib qho nce hauv lawv.
• Kev kuaj ntsuas - bilirubin, alkaline phosphatase, kev ua si gamma-glutamintranspeptidase yuav nce ntxiv, hauv qee qhov tsis tshua muaj, kev tsis txaus siab muaj txiaj ntsig los ntawm cov thyroid caj pas yuav raug sau tseg.
• Lwm cov tsos mob yog asthenia.

Feem ntau cov neeg mob nug cov lus nug - qhov kub puas nce ntxiv thaum noj rosuvastatin? Tsis yog, nws tsis yog. Kuv kuj tseem nco ntsoov tias tsis muaj kev sib raug zoo nrog statins nrog cawv, yog li cov neeg mob yuav tsum tsis haus dej haus cawv thaum lub sijhawm kho, txwv tsis pub lub sijhawm ntawm cov kev mob tshwm sim yuav nce rau lub sijhawm, thiab cov txiaj ntsig tau yog, alas, tsis tau.

Cov lus qhia rau kev siv

Feem ntau, cov tshuaj pib ntawm rosuvastatin yog 5-10 mg rau ib hnub, nyob ntawm lub hom phiaj ntawm kev kho mob thiab qhov mob ntawm tus neeg mob thiab nws lub cev. Ua ntej kev kho mob, kev noj zaub mov noj txhawm rau txo qis cov roj cholesterol yuav tsum raug pom. Yuav Ua Li Cas muab nws txoj cai rosuvastatin?

Cov tshuaj yuav tuaj yeem yuav qaug cawv tsis hais txog zaub mov, tam sim ntawd tag nrho cov tshuaj txhua hnub rau 1 zaug. Tsis txhob faib cov ntsiav tshuaj, tsis txhob zom lossis zom nws, coj nws qhov ncauj tag nrho, nrog ib khob dej. Dosage yog xaiv ib tus kheej thiab ua tib zoo. Yog tias tsim nyog, tom qab plaub lub lis piam, tus kws kho mob tuaj koom tuaj yeem nce qhov koob tshuaj kom ua tiav cov txiaj ntsig yam xav tau.

Nyob rau hauv kev xaiv ntawm kev txhaj tshuaj txhua hnub ntawm 40 mg, qhov kev pheej hmoo ntawm kev phiv tshuaj yog ntau ntxiv, yog li, qhov ntau npaum li cas ntawm cov tshuaj tau raug rau cov theem hnyav ntawm hypercholesterolemia thiab muaj kev pheej hmoo siab ntawm cov teeb meem los ntawm vascular system thiab lub plawv, yog tias qhov ntau npaum ntawm 20 mg tsis tau muab cov txiaj ntsig ua ntej. Nws yog ib qho tsim nyog yuav tsum tau ua txoj haujlwm los ua kev soj ntsuam ntawm lipid metabolism tom qab 2-4 lub lis piam los ntawm pib kev kho lossis nce qhov ntau npaum.

Yog tias tus neeg mob tau mob concomitant los ntawm ob lub raum, mob siab, cov leeg mus rau lub cev, ib qho zoo li mob myopathy, ces cov tshuaj pom zoo rau nws yog 5 mg rau ib hnub. Tam sim no cia txhais tau tias ntev li cas nws yuav siv sij hawm los noj rosuvastatin. Lub chav kawm ntawm kev kho mob yog kho tus kheej, tab sis nws lub sijhawm tsawg kawg yog ib hlis.

Siv thaum cev xeeb tub

Zoo ib yam li lwm yam statins, rosuvastatin thaum cev xeeb tub thiab lactation tsis tau txais.

Cov me nyuam lub hnub nyoog yog ib qho ntawm contraindications ntawm rosuvastatin. Tsis muaj kev tshawb fawb qhia txhua yam txog cov nyhuv ntawm cov menyuam yaus lub cev tau ua tiav, yog li no cov statin no tsis yog siv rau hauv kev xyaum tsiaj txhu.

Tus nqi tshuaj

Rau ntau tus neeg mob, ntxiv rau qhov zoo thiab cuam tshuam ntawm cov tshuaj, nws tus nqi yog hauv qhov chaw tseem ceeb. Rau rosuvastatin, tus nqi yog qhov nruab nrab piv rau tus nqi ntawm lwm cov lipid-txo analogues. Tus nqi rosuvastatin raug nqi ntau npaum li cas? Nyob ntawm thaj av, tus nqi sib txawv. Hauv Lavxias hauv cov khw muag tshuaj hauv Moscow, cov tshuaj tau muag ntawm cov nqi hauv qab no:

• rau 30 ntsiav tshuaj ntawm 5 mg - nqe ntawm 510 rubles
• rau 30 ntsiav tshuaj ntawm 10 mg - nqe ntawm 540 rubles
• rau 30 ntsiav tshuaj ntawm 20 mg txhua - nqe ntawm 850 rubles

Nyob rau hauv Ukraine rosuvastatin tus nqi yog qis dua. Tus nqi nruab nrab ntawm cov chaw muag tshuaj hauv Kiev yog nyob hauv cov haujlwm hauv qab no:

• rau 28 pcs. 5 mg txhua - nqe ntawm 130 UAH
• rau 28 pcs. 10 mg txhua - nqe los ntawm 150 UAH
• rau 28 pcs. 20 mg txhua - nqe los ntawm 230 UAH.

Yog lawm, tus nqi nyob ntawm qhov chaw tsim khoom lub tuam txhab, cov yam ntxwv ntawm lub tsev muag tshuaj txuas thiab txoj cai nqe tshwj xeeb ntawm ib cheeb tsam hauv lub tebchaws.

Kev Siv Tshuaj Xyuas

Ntawm cov neeg ua haujlwm kho mob, kev tshuaj xyuas ntawm rosuvastatin yog qhov zoo feem ntau. Nws suav hais tias yog cov tshuaj niaj hnub ntawm kev xaiv rau hypercholesterolemia nrog tus nqi / zoo piv. Feem ntau nws yog kws kho mob los tswj atherosclerosis. Los ntawm kev ua kom lub lipid ruaj khov, qhov kev pheej hmoo ntawm lub plawv nres thiab ntshav npleem yog txo qis.

Petrenkovich V.O. kws kho mob ntawm tsev neeg xyaum ntawm qeb siab tshaj plaws, Vinnitsa: “Hauv kuv qhov kev coj ua, Kuv tau siv rosuvastatin siv rau qee lub sijhawm thiab feem ntau. Txog rau cov neeg mob, Kuv nyiam sau ntawv rau nws ua tus Roxer. Hauv txhua kis, Kuv pom tias qhov kev kuaj mob ua tau zoo. Cov neeg mob kho tsis yws yws ntawm qhov tshwm sim tsis zoo, txoj kev kho yog zam zoo. Cov tshuaj muaj ntsis nyob rau hauv nqe "

Dua li ntawm qhov tseeb hais tias feem ntau cov tib neeg ntshai los ntawm daim ntawv teev cov txiaj ntsig tau los ntawm kev noj rosuvastatin, ntawm cov uas tsis muaj leej twg sau ntawv tshaj tawm cov tsos mob tsis zoo. Tus nqi thiab cov txiaj ntsig xav tau ntawm kev noj rosuvastatin ua rau nws lub hom phiaj.

Gorelkin Pavel, Novorossiysk: “Tau ntau xyoo tam sim no, kws kho mob tau hais tias kuv muaj cov roj (cholesterol) siab heev. Hauv kuv 42 xyoos, Kuv ntshai heev vim tuag los ntawm kev mob plawv nres. Ntawm lub tsev kho mob hauv nroog, kuv tau hais kom pib haus dej haus Suvardio. Tom qab li ib hlis thiab ib nrab, kuv qhov kev ntsuam xyuas tau zoo dua, nws tau yooj yim rau kuv tus ntsuj plig. Yuav ua li cas txog tus nqi? Zoo, tus nqi tsis tom ntau dhau, yog li kuv tuaj yeem them taus nws. Kuv tseem yuav mus kho "

Belchenko Z.I., 63 xyoo, lub zos. Akhtyrsky: “Tau ntau xyoo dhau los kuv tau kho kuv tus mob caj dab siab nrog cov kev kho mob pej xeem. Qhov kuv nyuam qhuav tsis tau sim, tsis muaj ib yam pab kuv. Xyoo tas los, ib tus neeg nyob ze kuv qhia kuv kom mus ntsib tus kws kho mob tshiab hauv qhov chaw kho mob. Muaj Kuv tau raug muab tshuaj rosuvastatin. Kuv tau hais txog cov tshuaj tshiab no thiab zoo heev. Txawm hais tias tus nqi tsis zoo heev rau kuv, tus nqi yog cov nqi, tab sis kuv tau haus nws rau ib lub xyoo tam sim no thiab kuv muaj cov roj cholesterol qub. "

Makashvili O.B., Hnub nyoog tshaj 50 xyoo, Kerch: “Txog ntawm nws tus tij laug, Tevastor pib ua raws. Kuv cov ntshav qab zib muaj mob zuj zus. Kuv tau mus rau tom tsev kho mob, qhov uas lawv hloov cov tshuaj nrog lwm cov tshuaj, tab sis yuav luag tus nqi. Nws tig tawm tias Tevastor yuav tsum tsis txhob noj tshuaj mob ntshav qab zib. "

Raws li koj tuaj yeem pom, raws li kev tshuaj xyuas ntawm ob tus kws kho mob thiab cov neeg mob, rosuvastatin muaj tus nqi zoo / kev sib piv zoo. Rosuvastatin yog cov tshuaj niaj hnub thiab siv tau zoo. Nrog kev ua raws li cov lus pom zoo rau kev kho mob, nws muaj daim ntawv qhia txog kev nyab xeeb thiab tuaj yeem tsim kho raws li kev kawm ntev.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj Rosuvastatin yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, zaj duab xis-ntsiav tshuaj rau kev tswj hwm qhov ncauj (qhov ncauj). Lawv muaj lub teeb xim liab lossis xim paj yeeb, puag ncig duab thiab thaj chaw biconvex.

Txhua lub ntsiav tshuaj yog xev txheej. Cov khoom tseem ceeb yog rosuvastatin.

• pob kws nplej siab
• magnesium stearate,
• microcrystalline cellulose,
• povidone
• calcium hydrogen phosphate dihydrate.

Muaj pes tsawg leeg zaj duab xis plhaub:

• selecate AQ-01032 liab,
• titanium dioxide
• hypromellose,
• macrogol-400,
• macrogol-6000.

Ua raws li cov koob tshuaj (10 mg, 20 mg, 40 mg), cov lus sib xyaw ntawm cov ntsiav tshuaj hloov pauv.

Pharmacological kev txiav txim

Rosuvastatin yog lipid-txo qis tus neeg sawv cev, xaiv sib tw inhibitor ntawm hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, uas yog ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl CoA rau lub zog ntawm cov roj uas txhaws taus - mevalonate. Cov tshuaj tsub kom tus naj npawb ntawm LDL receptors (tsawg lipoproteins tsawg) nyob rau saum npoo ntawm daim siab, ua rau catabolism muaj zog ntau thiab nce ntawm LDL thiab kev sib xyaw ntawm VLDL (qis lipoproteins tsawg) yog inhibited. Thaum kawg, tag nrho cov lej ntawm VLDL thiab LDL raug txo kom tsawg.

Raws li kev ua ntawm Rosuvastatin, ntau zog ntawm OXC (tag nrho cov roj cholesterol), roj-LDL (cov roj lipoproteins tsawg), TG (triglycerides), ApoB (apolipoprotein B), TG-VLDL thiab VL-VLDL raug txo qis. Cov tshuaj tsub kom nce siab ntawm HDL-C (HDL roj cholesterol) thiab ApoA-I (apolipoprotein A-I). Rosuvastatin txo cov tshuaj atherogenicity index, txhim kho lipid profile hauv cov neeg mob hypercholesterolemia.

Kev kho mob ntawm cov tshuaj tshwm sim hauv thawj lub lis piam tom qab pib kev tswj hwm, nce mus txog ntau kawg los ntawm lub lim tiam plaub ntawm chav kawm.

Cov Tshuaj Pharmacokinetics

Qhov siab tshaj plaws ntshav ntshav ntawm cov khoom nquag nce mus txog 5 teev tom qab noj Rosuvastatin. Kev tsis raug cai txog ntawm kev txheeb txog ntawm txog 20%.

Lub ntsiab metabolism yog nqa tawm los ntawm lub siab. Qhov ntim ntawm kev faib tawm yog 134 litres. Txog 90% ntawm cov khoom sib txuas rau cov ntshav plasma protein (feem ntau yog nrog albumin). Lub ntsiab metabolites yog lactone metabolites (tsis muaj cov haujlwm ntawm pharmacological) thiab N-desmethylrosuvastatin (50% tsis tshua muaj siab tshaj li rosuvastatin).

Kwv yees li 90% ntawm kev txhaj tshuaj yog kho tawm los ntawm txoj hnyuv tsis hloov, qhov seem ntawm lub raum. Lub plasma ib nrab-lub neej yog 19 teev.

Cov tshuaj pharmacokinetics ntawm rosuvastatin tsis vam khom rau poj niam txiv neej thiab hnub nyoog ntawm tus neeg mob.

Hauv cov neeg ntawm haiv neeg Mooboid, muaj ob zaug nce ntxiv rau qhov siab tshaj plaws plasma concentration ntawm rosuvastatin thiab nruab nrab AUC (thaj chaw hauv qab qhov kev xav-lub sijhawm nkhaus) piv nrog Caucasoid cov neeg mob, hauv Isdias Asmesliskas cov ntshav plasma qhov siab tshaj plaws thiab nruab nrab AUC nce ntawm 1.3 zaug, hauv cov neeg sawv cev ntawm Negroid haiv neeg pharmacokinetic parameters zoo ib yam li cov neeg hauv Caucasians.

Ntshav qis los yog mob raum tsis ua rau muaj kev cuam tshuam ntau ntxiv ntawm rosuvastatin thiab nws cov metabolite N-desmethylrosuvastatin. Hauv kev mob tsis zoo hauv lub raum, cov ntshav ntawm rosuvastatin nce ntxiv li ntawm peb zaug, thiab N-desmethylrosuvastatin los ntawm cuaj zaug. Hauv cov neeg mob ntawm kev mob hemodialysis, qhov tshuaj lom ntawm cov tshuaj nquag yog kwv yees li 50% siab dua.

Hauv cov neeg mob uas muaj mob tsis txaus siab rau hepatic, ib nrab-lub neej ntawm rosuvastatin yuav nce tsawg kawg yog ob zaug.

Cov tshuaj noj thaum cev xeeb tub thiab lactation

Rosuvastatin thiab lwm yam statins yog contraindicated hauv kev xeeb tub. Muaj cov pov thawj tias cov tshuaj no cuam tshuam tsis zoo rau kev yug menyuam, ua rau muaj kev pheej hmoo ntawm qhov tsis zoo nyob hauv cov menyuam tshiab. Cov pojniam muaj hnub nyoog yug me nyuam uas siv cov statins yuav tsum ua tib zoo siv txoj kev tswj kom tsis muaj menyuam.

Yog tias qhov kev xeeb tub tsis tau pom tshwm sim, tom qab ntawd noj tshuaj rau cov cholesterol kom nres tam sim ntawd. Nws tsis pom zoo kom pub niam mis thaum lub sijhawm kho nrog cov tshuaj no.

Dosage thiab txoj kev ntawm cov thawj coj

Raws li qhia hauv cov lus qhia rau kev siv, rosuvastatin noj ntawm qhov ncauj, tsis txhob zom lossis zom cov ntsiav tshuaj, nqos tag nrho, ntxuav nrog dej. Cov tshuaj tuaj yeem tuaj yeem sau lub sijhawm thaum nruab hnub, tsis hais lub sijhawm noj mov.

Ua ntej pib txoj kev kho mob nrog Rosuvastatin, tus neeg mob yuav tsum pib ua raws li ib qho kev cai hypocholesterolemic noj haus thiab txuas ntxiv ua raws nws thaum kho. Cov koob tshuaj ntawm cov tshuaj yuav tsum tau xaiv ib tus zuj zus nyob ntawm lub hom phiaj ntawm txoj kev kho thiab kho cov lus teb rau kev kho mob, suav txog cov lus pom zoo tam sim no ntawm cov phiaj lipid ntau.

• Qhov pom zoo kom pib noj rau cov neeg mob pib noj cov tshuaj, lossis rau cov neeg mob hloov mus los ntawm kev noj lwm cov tshuaj HMG-CoA reductase inhibitors, yuav tsum yog 5 lossis 10 mg ntawm cov tshuaj Rosuvastatin 1 zaug / hnub. Thaum xaiv cov tshuaj xub thawj, ib qho yuav tsum tau ua los ntawm tus neeg cov roj (cholesterol) hauv lub cev thiab coj mus rau hauv qhov kev pheej hmoo ntawm cov kab mob plawv, thiab nws tseem yuav tsum tau ntsuas qhov muaj feem tshwm sim ntawm kev mob tshwm sim. Yog tias tsim nyog, cov koob tshuaj tuaj yeem nce ntxiv mus rau qhov ntau dua tom qab 4 lub lis piam (saib ntu "Pharmacodynamics").
• Vim tias qhov tshwm sim muaj feem ntawm kev phiv thaum noj ib koob tshuaj 40 mg, piv nrog koob tshuaj qis dua (saib Ntu “Kev phiv tshuaj”), nce qhov koob rau 40 mg tom qab ib qho kev noj tshuaj ntxiv yog siab dua qhov kev xav pom zoo pib rau 4 lub lis piam kev kho tuaj yeem nqa tawm tsuas yog hauv cov neeg mob uas muaj mob siab hypercholesterolemia thiab muaj kev pheej hmoo siab ntawm cov hlab plawv mob (tshwj xeeb tshaj yog nyob rau cov neeg mob nrog tsev neeg hypercholesterolemia) uas tsis tau tiav qhov xav tau tshwm sim ntawm txoj kev kho thaum noj ib koob tshuaj 20 mg, thiab leej twg yuav t yuav nyob rau hauv lub saib xyuas ntawm ib tug kws (saib. seem "Tshwj xeeb cov lus qhia"). Pom zoo tshwj xeeb kev saib xyuas ntawm cov neeg mob tau txais cov tshuaj hauv ib koob tshuaj 40 mg yog pom zoo.

Kev noj tshuaj ntawm 40 mg tsis pom zoo rau cov neeg mob uas tsis tau mus ntsib kws kho mob dhau los. Tom qab 2-4 lub lis piam ntawm kev kho thiab / lossis nrog kev nce ntxiv ntawm qhov tshuaj ntawm Rosuvastatin, kev saib xyuas cov lipid metabolism yog qhov tsim nyog (koob tshuaj yog tsim nyog yog tias tsim nyog). Kev siv cov tshuaj hauv qhov siab dua 40 mg tsis pom zoo nyob rau hauv kev sib txuas nrog qhov nce ntawm cov kev mob tshwm sim thiab feem ntau tsis pom zoo.

1. Nrog creatinine tshem tawm ntawm 30-60 ml / min, Rosuvastatin yog tshuaj rau hauv thawj zaug koob tshuaj 5 mg. Kev siv cov tshuaj nyob rau hauv ib koob tshuaj txhua hnub ntawm 40 mg yog contraindicated. Cov neeg mob nrog creatinine tshem tawm tsawg dua 30 ml / min, zoo li muaj mob ntawm daim siab ua haujlwm nyob rau theem nquag, tsis yog kws kho mob.
2. Kev pom zoo kom pib koob tshuaj rau cov neeg mob ntawm haiv neeg Mongoloid yog 5 mg. Hauv koob tshuaj 40 mg, cov tshuaj tsis raug cai rau pawg neeg no.
3. Rau cov neeg mob nqa tshuaj genotypes c.521SS lossis s.421AA, qhov pom zoo ntau tshaj plaws txhua hnub ntawm Rosuvastatin yog 20 mg.
4. Thaum muaj teeb meem tshwm sim rau kev txhim kho myopathy, qhov kev xav kom pib yog 5 mg, qhov ntau tshaj yog 20 mg.
5. Thaum kws kho mob muab kev kho ua ke, nws yog ib qho tsim nyog los ntsuas qhov ntxim nyiam ntawm kev tsim myopathy.

Sab sij huam

Cov kev ua txhaum pom nyob rau hauv txoj kev kho yog feem ntau koob tshuaj thiab tsis nco qab thiab nws tus kheej ploj mus.

Cov kev tsis haum siab (> 10% - ntau heev,> 1% thiab 0.1% thiab 0.01% thiab Sasha. Tus kws kho mob tau hais rau kuv rosuvastatin 1 ntsiav tshuaj ib zaug ib hmos. Kuv tau pib haus cawv thiab kuv lub siab pib ntaus txawv heev. Raws li - Kuv tsis haus cawv lawm thiab lub plawv dhia zoo li nres. Kuv nyeem cov lus qhia hais tias lawv yuav ua rau cov hlab plawv tsis ua haujlwm lawm. Kuv yuav tsum tsis txhob haus dej lawm.

Muaj ib tug xov tooj ntawm cov tshuaj uas muaj tib lub active tshuaj zoo li rosuvastatin, thiab yog li ntawd tuaj yeem siv ua lwm txoj hauv kev. Txawm li cas los xij, ua ntej siv lawv, nws yeej pom zoo kom koj sab laj nrog koj tus kws kho mob.

Cov kev xaiv muaj:

Ua ntej koj yuav ib qho analog, tham nrog koj tus kws kho mob.