Pentilin (Pentilin) > Kev khomob thiab kev tiv thaiv

Sab hauv, thaum lossis tom qab noj mov, nqos tag nrho, 400 mg 2-3 zaug ib hnub, muaj chav kawm - tsawg kawg yog 8 lub lis piam.

Hauv / hauv lossis hauv / ib qho kev txhaj tshuaj: 50-100 mg / hnub (hauv saline) rau 5 feeb. Hauv / hauv lossis hauv / ib qho kev lis ntshav: 100-400 mg / hnub (hauv physiological saline), lub sijhawm ntawm tso dej tso ntshav - 90-180 feeb, hauv / a - 10-30 feeb, qhov siab tshaj plaws txhua hnub koob ntawm 800 thiab 1200 mg, ntsig txog. Txoj kev sib txuas tas mus li - 0.6 mg / kg / h rau 24 teev, qhov siab tshaj plaws ib hnub ib zaug yog 1200 mg.

Nrog Cl creatinine tsawg dua 10 ml / min, qhov koob tshuaj raug txo los ntawm 50-70%. Rau cov neeg mob ntawm hemodialysis, kev kho mob pib nrog ib koob ntawm 400 mg / hnub, uas yog nce ntxiv rau ib txwm nrog ib nrab hnub tsawg kawg 4 hnub.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

kev daws teeb meem rau cov tshuaj ua haujlwm thiab tso ntshav ntawm lub cev: pob tshab, tsis muaj xim lossis daj me ntsis hauv xim (5 ml hauv ampoules, 5 ampoules hauv qhov tawm ntsej lossis lub tais yas, 1 blister lossis tais hauv cardboard pob),
ntsiav tshuaj ntawm lub sijhawm ntev ua, zaj duab xis-coated: oval, biconvex, dawb (10 pcs. hauv ib lub hlwv, hauv daim duab los qhia lub thawv 2 blisters).

Kev Sau Tseg ntawm 1 ampoule ntawm Pentilin tov (5 ml):

cov tshuaj nquag: pentoxifylline - 100 mg,
cov khoom siv ntxiv: sodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, disodium edetate, dej rau kev txhaj tshuaj.

Muaj pes tsawg leeg ntawm 1 ntsiav tshuaj Pentilin:

cov tshuaj nquag: pentoxifylline - 400 mg,
cov khoom siv ntxiv: magnesium stearate, hypromellose, macrogol 6000, silicon dioxide anhydrous colloidal,
plhaub: hypromellose, macrogol 6000, talc, titanium dioxide E171.

Cov Tshuaj Hauv Tshuaj

Pentoxifylline - cov tshuaj nquag ntawm Pentilin - ib qho antispasmodic los ntawm cov pab pawg purine uas txhim kho rheological zog (fluidity) thiab ntshav microcirculation. Lub tshuab ntawm kev txiav txim ntawm cov tshuaj yog vim nws lub peev xwm los tiv thaiv phosphodiesterase thiab nce qhov kev xav ntawm cyclic AMP hauv platelets thiab ATP hauv cov ntshav liab, thaum zaum siab rau lub zog muaj zog, vim tias vasodilation tsim kho, tag nrho peripheral vascular tsis kam txo, mob stroke thiab feeb ntim ntshav nce ntxiv, thaum lub plawv dhia tsis txaus. tab tom hloov.

Pentoxifylline dilates cov hlab ntsha cov hlab ntshav, uas nce oxygen xa mus rau myocardium (cov nyhuv antianginal), thiab cov hlab ntshav ntawm lub ntsws, uas txhim kho cov ntshav oxygen.

Cov tshuaj tsub kom lub suab nrov ntawm cov leeg ua pa, tshwj xeeb tshaj yog cov diaphragm thiab intercostal leeg.

Nws pab txhim kho cov ntshav microcirculation nyob rau hauv thaj chaw ntawm kev tsis txaus, nce qhov elasticity ntawm erythrocyte membrane, txo cov ntshav viscosity.

Nrog occlusive qhov txhab ntawm peripheral hlab ntsha (sib quas ntus claudication), Pentilin lengthens qhov kev ncua deb taug kev, tshem tawm kev pw ib hmos ntawm lub plab hlaub nqaij thiab mob ntawm so.

Cov Tshuaj Pharmacokinetics

Pentoxifylline yog dav kho ntau ntxiv hauv cov ntshav liab thiab lub siab. Tom qab lub qhov ncauj tswj hwm, nws yuav luag txhua yam nqus tau ntawm txoj hnyuv mus. Lub caij nyoog ntev ntawm cov ntsiav tshuaj muab ib qho kev tso tawm tas mus li ntawm cov tshuaj txuam nrog tshuaj thiab nws txoj kev niaj hnub nqus.

Pentoxifylline yauv nkag mus rau hauv lub siab mus rau daim siab, uas ua rau ob lub tshuaj pharmacologically nquag metabolites: 1-3-carboxypropyl-3,7-dimethylxanthine (metabolite V) thiab 1-5-hydroxyhexyl-3,7-dimethylxanthine (metabolite I), ntshav qhov kev nkag siab ntawm uas yog 8 thiab 5 zaug siab dua li pentoxifylline, feem.

Pentoxifylline thiab nws cov metabolites tsis khi rau cov protein tsis muaj ntshav.

Cov tshuaj nyob rau hauv daim ntawv ntev ntev ncav nws qhov siab tshaj plaws nyob rau hauv 2-4 teev. Nws tau faib tusyees. Qhov kev tshem tawm ib nrab-lub neej yog 0.5-1.5 teev.

Ib nrab-lub neej ntawm pentoxifylline tom qab kev tso dej ntawm 100 mg yog kwv yees li 1.1 teev. Nws muaj cov ntim loj ntawm kev faib tawm (tom qab 30 feeb ntawm 200 mg - 168 L), nrog rau kev ua haujlwm siab (4500-5100 ml / min).

94% ntawm cov koob tshuaj tau txais yog tawm los ntawm lub raum hauv daim ntawv ntawm metabolites (feem ntau metabolite V), kwv yees li 4% - los ntawm txoj hnyuv. Hauv qhov no, txog li 90% ntawm qhov koob tshuaj tau tawm hauv thawj 4 teev. Kev txo qis ntawm cov khoom noj metabolites qeeb qeeb hauv cov neeg mob uas mob raum tsis zoo. Thaum lub ntsej muag ua rau lub siab ua haujlwm tsis txaus, lub neej ib nrab ntawm pentoxifylline yog ntev thiab nws txoj kev ua kom bioavailability nce ntxiv.

Pentoxifylline yog txawj tawm hauv niam cov kua mis.

Kev ntsuas rau siv

hnov lus ntawm vascular keeb kwm,
mob ntsws, subacute thiab mob ntshav hlab plawv tsis ua haujlwm nyob hauv qhov retina thiab choroid,
mob hlwb cerebrovascular ntawm ischemic keeb kwm,
obliterating endarteritis,
peripheral ncig ntshawv siab vim yog atherosclerosis, mob ntshav qab zib mellitus (mob ntshav qab zib angiopathy),
angiopathy (paresthesia, Raynaud's disease),
cov nqaij mos ua rau lub qhov txhab ua rau vim cov leeg nqaij lossis cov hlab ntsha txhaws (ua pa rau lub cev, mob tom qab mob ntshav qab zib, mob rau sab hauv, mob caj dab),
discirculatory thiab atherosclerotic encephalopathies.

Cov Yuav Tsum Muaj

nqaij hlav hauv hlwb,
mob raum ntshav,
ntshav los ntau
hemorrhagic mob stroke,
mob loj kawg,
uncontrolled arterial hypotension,
mob myocardial infarction,
atherosclerotic mob hnyav ntawm cov hlab ntshav txhaws los yog hlab ntsha hauv hlab ntsha,
porphyria
cev xeeb tub, lactation,
hnub nyoog txog 18 xyoo
muaj qhov tsis haum xeeb rau Pentilin Cheebtsam lossis lwm yam tshuaj methylxanthines.

arterial hypotension,
mob plawv tsis ua hauj lwm
lub raum khiav tsis zoo (ua kom tshem tawm hauv qab 30 ml / min),
mob siab ua rau daim siab,
nce siab rau txoj kev los ntshav, suav nrog thaum siv cov tshuaj tiv thaiv kev tiv thaiv, kev cuam tshuam ntawm cov ntshav coagulation system, tom qab nyuam qhuav raug phais mob,
peptic rwj ntawm lub plab thiab duodenum rau ntsiav tshuaj.

Kev daws rau kev txhaj tshuaj

Hauv daim ntawv ntawm txoj kev daws teeb meem, Pentilin tau muab tshuaj rau hauv qhov quav los yog hauv ntsej muag.

Tus kws kho mob txiav txim siab txoj hauv kev ntawm kev tswj hwm thiab qib siab zoo tshaj plaws ntawm cov tshuaj rau txhua tus neeg mob, nyob ntawm qhov mob hnyav ntawm cov mob ntshav tsis txaus thiab ib leeg zam rau pentoxifylline Txoj kev nqus ntshav yog nqa tawm hauv txoj haujlwm supine.

Raws li txoj cai, rau cov neeg mob cov laus, cov tshuaj tau muab rau noj 2 zaug ib hnub (yav sawv ntxov thiab yav tav su), 200 mg (2 ampoules ntawm 5 ml txhua) lossis 300 mg (3 ampoules ntawm 5 ml txhua) hauv 250 lossis 500 ml ntawm 0.9% sodium chloride tov los sis lub tswb qhov ncauj. Kev sib xyaw nrog lwm cov kev daws teeb meem yuav tsum tau sim nyias, tab sis tsuas yog cov kev daws teeb meem yuav tsum tau siv.

Lub sijhawm tiv thaiv ntawm Txoj kev lis ntshav yog tsawg kawg 60 feeb rau ib koob ntawm pentoxifylline 100 mg. Cov koob tshuaj txhaj ntau yuav txo tau qhov muaj cov kabmob concomitant, piv txwv li, lub plawv tsis ua haujlwm. Hauv cov xwm txheej zoo li no, nws tsim nyog siv tus infuser tshwj xeeb los tswj txoj kev lis ntshav.

Tom qab ib hnub Txoj kev lis ntshav, yog tias tsim nyog, Pentilin 400 mg ntsiav tshuaj ntxiv tau ntxiv - 2 pcs. Yog tias ob lub tshuaj hnoos yog tsim nyob ntev dua, tom qab ntawd 1 lub tshuaj yuav noj thaum ntxov (thaum txog 12 teev ib tav su).

Nyob rau hauv rooj plaub uas qhov kev tso ntshav mob ntshav vim yog cov kab mob kev saib xyuas tuaj yeem nqa ib zaug ib hnub, kev saib xyuas ntxiv ntawm Pentilin hauv cov ntsiav tshuaj hauv qhov nyiaj ntawm 3 pcs yog ua tau. (2 ntsiav tshuaj thaum tav su, 1 yav tsaus ntuj).

Hauv cov teeb meem loj, piv txwv li, nrog mob caj dab, mob thiav voos ntawm III - IV theem raws li kev faib tawm ntawm Fontaine - Lerish - Pokrovsky, mob hnyav ntawm so, kev siv tshuaj tiv thaiv ntev ntawm cov tshuaj yog qhia - rau 24 teev.

Cov tshuaj pom zoo siv rau kev tswj hwm: thaum pib kho - 100 mg ntawm pentoxifylline hauv 50-100 ml ntawm 0.9% sodium chloride tov, nyob rau hnub tom ntej - 100-400 mg hauv 50-100 ml ntawm 0.9% sodium chloride tov. Kev ntsuas kev tswj hwm yog 10 mg / feeb, lub sijhawm ua haujlwm yog 10-30 feeb.

Thaum nruab hnub, koj tuaj yeem nkag mus rau cov tshuaj hauv ib koob kom txog 1200 mg. Hauv qhov no, koob tshuaj rau ib tus neeg tuaj yeem txiav txim siab raws li cov qauv hauv qab no: 0.6 mg ntawm pentoxifylline ib kg ntawm lub cev hnyav hauv ib teev. Yog li, qhov koob tshuaj txhua hnub yuav yog 1000 mg rau tus neeg mob uas lub cev hnyav txog 70 kg, 1150 mg rau tus neeg mob lub cev hnyav 80 kg.

Cov neeg mob lub raum tsis ua haujlwm, nyob ntawm tus neeg kam rau siab ntawm cov tshuaj, txo cov koob tshuaj los ntawm 30-50%.

Kev txo qis qis kuj tseem yuav tsum muaj nyob hauv cov neeg mob uas muaj lub siab tsis ua haujlwm zoo, thaum Pentilin kev cia siab rau ib tus neeg yuav tsum raug txiav txim siab.

Nws raug nquahu kom pib kho nrog rau cov koob tshuaj qis dua nrog cov neeg mob ntshav siab tsawg zuj zus, nrog rau cov neeg mob txo qis ntshav siab (piv txwv li, muaj mob plawv mob ntshav siab ntau, hemodynamically tseem ceeb stenosis ntawm cerebral hlab ntsha).

Pentilin 400 mg ntsiav tshuaj yuav tsum noj qhov ncauj, tom qab noj mov: nqos tag nrho thiab haus dej kom ntau.

Cov koob tshuaj pom zoo yog 1 ntsiav tshuaj 2 lossis 3 zaug hauv ib hnub. Tsis pub tshaj ib qho tshuaj txhua hnub ntawm 1200 mg.

Cov neeg mob uas mob raum tsis ua hauj lwm zoo (kev tshem tawm creatinine)

Dosage daim ntawv

400 mg zaj duab xis-coated ntsiav tshuaj

Ib ntsiav tshuaj muaj

cov tshuaj nquag - pentoxifylline 400 mg,

tus zam: hypromellose, macrogol 6000, magnesium stearate, silicon dioxide colloidal anhydrous,

plhaub muaj pes tsawg leeg: hypromellose, macrogol 6000, titanium dioxide (E 171), talc.

Cov ntsiav tshuaj zoo li dawb lub ntsej muag nrog lub ntsej muag biconvex, txheej nrog cov xim zaj duab xis dawb

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, pentoxifylline yog nrawm thiab ua kom tiav. Lub bioavailability ntawm lub caij nyoog-tso pentoxifylline ntsiav tshuaj yog kwv yees li 20%. Noj qeeb qeeb, tab sis tsis txo qis qhov ua tiav ntawm kev nqus ntawm cov tshuaj.

Qhov siab tshaj plaws ntshav plasma tshwm sim nyob rau hauv 2 txog 4 teev. Pentoxifylline raug nthuav tawm hauv niam cov kua mis, kuaj pom tsis pub dhau 2 teev tom qab kev tswj hwm, hauv ob qho tib si - tsis hloov pauv thiab hauv daim ntawv ntawm metabolites.

Pentoxifylline yog metabolized feem ntau nyob rau hauv daim siab thiab ua rau tsawg dua nyob rau hauv cov ntshav liab. Nws hla dhau ib qho tseem ceeb thiab pom meej metabolism hauv thawj kis. Plasma cov ntsiab lus ntawm cov metabolites nquag yog 5 thiab 8 npaug ntau dua li cov concentration ntawm pentoxifylline. Nws yog metabolized los ntawm kev cog lus (ntawm α-keto reductase) thiab oxidation.

Metabolites ua rau mob tawm hauv cov zis (li 95%). Txog li 4% ntawm qhov kev noj tshuaj tau tawm los ntawm cov quav. Hauv lub raum ua rau lub cev tsis mob plab, qhov ua kom tsis taus ntawm metabolites yog qeeb. Nrog hepatic dysfunction, ib nrab-lub neej yog ntev thiab bioavailability nce. Hauv qhov no, yuav kom zam tau cov kev sib txuam ntau ntawm cov tshuaj hauv lub cev ntawm cov neeg mob zoo li no, cov tshuaj yuav tsum raug txo kom tsawg.

Cov Tshuaj Hauv Tshuaj

Pentoxifylline txhim kho rheological cov yam ntxwv ntawm cov ntshav los ntawm cuam tshuam rau hloov kho pathologically hloov pauv ntawm cov ntshav liab, inhibiting platelet kev sib sau thiab txo cov ntshav viscosity. Tus txheej txheem ntawm kev ua ntawm pentoxifylline txhawm rau txhim kho rheological yam ntxwv ntawm cov ntshav suav nrog kev nce ntxiv ntawm cov ntshav liab hauv cov qib ntawm ATP (adenosine triphosphate), cAMP (cyclo-adenosine monophosphate) thiab lwm cov cyclic nucleotides. Pentoxifylline txo qis viscosity ntawm ntshav thiab ntshav los ntawm kev txo qis cov concentration ntawm fibrinogen. Xws li ib qho kev txo qis hauv cov tshuaj fibrinogen yog qhov tshwm sim los ntawm kev nce hauv cov kev ua haujlwm fibrinolytic thiab txo qis hauv nws cov synthesis. Tsis tas li ntawd, los ntawm inhibiting membrane-khi phosphodiesterase enzymes (uas ua rau muaj kev nce cAMP concentration) thiab thromboxane synthesis, pentoxifylline muaj zog inhibits spontaneous thiab yuam platelet aggregation thiab tib lub sijhawm txhawb cov synthesis ntawm prostacyclin (prostaglandin I2).

Pentoxifylline txo cov khoom tsim tawm ntawm interleukin hauv monocytes thiab macrophages, uas txo qhov hnyav ntawm cov tshuaj tiv thaiv. Pentoxifylline txhim kho peripheral thiab cerebral ntshav txaus, tsub kom ntau koob tshuaj tiv thaiv ib feem ntawm cov pa oxygen nyob rau hauv cov leeg ntawm ischemic cuam tshuam qis qis, nyob rau hauv cerebral cortex thiab cerebrospinal kua, nyob rau hauv retina ntawm cov neeg mob nrog retinopathy.

Sab sij huam

Cov hauv qab no yog cov kev mob tshwm sim thaum lub sijhawm sim kho mob thiab tom qab lub sijhawm muag khoom.
Los ntawm cov hlab plawv system. Arrhythmia, tachycardia, angina pectoris, txo qis ntshav siab, nce ntshav siab.
Los ntawm cov lymphatic system thiab cov ntshav system. Thrombocytopenia, thrombocytopenic purpura, aplastic anemia (ib nrab lossis ua kom tiav ntawm kev tsim txhua cov qe ntshav), pancytopenia, uas tuaj yeem ua rau neeg tuag taus.
Los ntawm lub paj hlwb tawg. Kiv taub hau, mob taub hau, mob leeg ntshav taub hau, tshee tshee, plab hlaub, leeg.
Los ntawm cov mob hauv plab zom mov. Kev mob plab zom mov, qhov kev hnov ntawm lub siab hauv plab, pom pob, xeev siab, ntuav, lossis zawv plab.
Ntawm feem ntawm daim tawv nqaij thiab cov ntaub so ntswg subcutaneous. Cov khaus, liab ntawm daim tawv nqaij thiab urticaria, mob toxic epidermal necrolysis thiab mob Stevens-Johnson mob.
Kev ua txhaum ntawm cov leeg ntshav muaj nuj nqi. Hnov qhov sov (kub dhau los), los ntshav, ua rau tawv nqaij.
Los ntawm lub cev tiv thaiv kab mob. Cov tsos mob anaphylactic, cov tshuaj tiv thaiv anaphylactoid, angioedema, bronchospasm thiab anaphylactic kev poob siab.
Ntawm ib sab ntawm lub siab thiab tsib lub zais zis. Mob leeg cholestasis.
Mob hlwb Ua haujlwm tsis zoo, pw tsis taus, nrog kev sib tham.
Los ntawm ob sab ntawm cov plab hnyuv siab raum ntawm lub zeem muag. Pom kev tsis zoo, pom pob txha hlaws pob txha, mob hlaus pob txha, mob hlwb txhaws.
Lwm tus. Cov neeg mob ntshav qab zib, tawm hws ntau dhau, thiab kub taub hau tau tshaj tawm.

Cev xeeb tub

Tsis muaj kev paub txaus nrog cov tshuaj no Pentiline poj niam muaj me nyuam. Yog li, nws tsis pom zoo kom sau ntawv tshuaj Pentilin thaum cev xeeb tub.
Pentoxifylline me me kis mus rau hauv niam mis. Yog tias Pentilin raug cai, tsum tsis pub mis niam.

Kev cuam tshuam nrog lwm yam tshuaj

Cov nyhuv ntawm kev txo qis ntshav qab zib cov kab mob hauv cov kua dej los yog cov tshuaj tiv thaiv kab mob hauv qhov ncauj yuav ua kom zoo dua. Yog li, cov neeg mob uas tau txais tshuaj kho mob ntshav qab zib yuav tsum tau ua tib zoo saib.
Hauv lub sijhawm tshaj tawm tom qab tau tshaj tawm, cov xwm txheej ntawm cov tshuaj tiv thaiv kev tiv thaiv tau tshaj tawm hauv cov neeg mob uas tau ua ke nrog pentoxifylline thiab anti-vitamin K. Thaum noj pentoxifylline yog tau sau lossis hloov pauv, nws raug nquahu kom soj qab saib qhov kev tiv thaiv ntawm cov neeg mob no.
Pentiline tuaj yeem txhim kho cov nyhuv antihypertensive ntawm cov tshuaj tiv thaiv kabmob thiab lwm yam tshuaj, uas tuaj yeem ua rau txo qis ntshav siab.
Kev siv pentoxifylline thiab theophylline tib lub sijhawm cov neeg mob tuaj yeem ua rau nce theophylline ntau ntxiv hauv cov ntshav. Yog li ntawd, nws muaj peev xwm nce lub zaus ntxiv thiab nce qhov tshwm sim ntawm kev phiv tshuaj ntawm theophylline.
Ketorolac, meloxicam.
Siv tib lub sijhawm pentoxifylline thiab ketorolac tuaj yeem ua rau kom lub sijhawm prothrombin nce ntxiv thiab muaj kev pheej hmoo los ntshav. Txoj kev pheej hmoo los ntshav kuj tseem tuaj yeem siv ntxiv nrog kev siv pentoxifylline thiab meloxicam tib lub sijhawm. Yog li, kev kho mob nrog rau cov tshuaj no tsis pom zoo.

Noj ntau dhau

Cov tsos mob thawj zaug muaj kev siv ntau dhau Pentiline yog xeev siab, kiv taub hau, tachycardia, lossis ntshav siab poob qis.Ntxiv rau, cov tsos mob xws li kub taub hau, ntxhov siab, hnov mob kub (kub taub hau), tsis nco qab, areflexia, tonic-clonic qaug dab peg thiab ntuav ntawm cov xim hauv kas fes kuj tseem tuaj yeem ua raws li cov cim qhia rwj ntawm txoj hnyuv los ntshav.
Kev Kho Mob. Txhawm rau kho tus mob ntau dhau thiab tiv thaiv qhov tshwm sim ntawm cov kev mob tshwm sim, kev saib xyuas dav dav thiab tshwj xeeb kev saib xyuas kev noj qab haus huv thiab kev coj los kho tus mob yog tsim nyog.

Daim ntawv thov nta

Ntawm thawj cov tsos mob ntawm tus mob anaphylactic / tshuaj tiv thaiv anaphylactoid, kev kho mob nrog pentoxifylline yuav tsum tau tsum tsis ua ntxiv thiab nrhiav tswv yim kho mob.

Tshwj xeeb kev saib xyuas mob tshwj xeeb yog xav tau rau cov neeg mob lub plawv dhia tsis ua hauj lwm, mob ntshav qis, hlab ntsha txhaws, thiab cov uas muaj mob plawv lossis phais.

Tus pentoxifylline, cov neeg mob uas lub plawv tsis ua haujlwm yuav tsum xub mus txog theem ntawm cov ntshav cov nyiaj tau los.

Rau cov neeg mob uas muaj cov kab mob lupus erythematosus (SLE) los yog sib xyaw cov nqaij mob sib kis, pentoxifylline tuaj yeem tsuas yog tom qab tshuaj ntsuam xyuas meej ntawm cov kev pheej hmoo thiab cov txiaj ntsig.

Vim txoj kev pheej hmoo ntawm hemorrhage nrog kev siv pentoxifylline thiab kev siv tshuaj tiv thaiv kab mob hauv lub qhov ncauj, ua tib zoo saib xyuas thiab nquag saib xyuas cov ntshav coagulation tsis dhau (thoob ntiaj teb li qub piv (MES)) yog qhov tsim nyog.

Txij li thaum muaj kev pheej hmoo ntawm ntshav tsis txaus thaum lub sijhawm kho nrog pentoxifylline, yuav tsum tau soj ntsuam kev kuaj ntshav tas mus li.

Hauv cov neeg mob ntshav qab zib thiab tau txais kev kho mob nrog insulin lossis tshuaj tiv thaiv kab mob hauv lub qhov ncauj, nrog rau kev siv ntau ntawm pentoxifylline, nws muaj peev xwm nce cov nyhuv ntawm cov tshuaj no rau cov ntshav qab zib (saib Ntu "Kev cuam tshuam nrog lwm yam tshuaj thiab lwm yam kev sib cuam tshuam").

Hauv cov neeg mob uas lub raum tsis ua haujlwm (kev tshem tawm creatinine tsawg dua 30 ml / min) lossis mob siab tsis ua haujlwm, pentoxifylline kev tshem tawm yuav qeeb. Kev tshuaj xyuas kom zoo yog xav tau.

Cov neeg mob lub raum tsis ua hauj lwm. Hauv cov neeg mob uas lub raum tsis ua haujlwm (kev tsim muaj peev xwm tsis pom zoo tsawg tshaj li 30 ml / min), kev tso tshuaj feem ntau txog 50-70% ntawm qhov qauv koob tshuaj yuav tsum tau nqa tawm mus rau hauv tus account kam rau tus neeg, piv txwv li, siv pentoxifylline 400 mg 2 zaug hauv ib hnub es tsis txhob siv 400 mg 3 zaug hauv ib hnub.

Cov neeg mob uas muaj lub siab ua rau lub siab ua haujlwm. Hauv cov neeg mob uas muaj lub siab tsis ua haujlwm siab, kev txiav txim siab los txo lub koob tshuaj yuav tsum ua los ntawm tus kws kho mob, suav txog qhov mob hnyav thiab zam rau txhua tus neeg mob.

Kev saib xyuas tshwj xeeb yog qhov tsim nyog rau:

cov neeg mob lub plawv dhia tsis xwm yeem,
cov neeg mob nrog myocardial infarction
cov neeg mob nrog arterial hypotension,
cov neeg mob uas mob atherosclerosis ntawm cov hlab ntsha hlwb thiab ntshav hlab ntsha, tshwj xeeb tshaj yog nrog concomitant arterial tawg thiab mob plawv dhia tsis ua haujlwm. Hauv cov neeg mob no, nrog kev siv tshuaj, mob tawm tsam angina, arrhythmias thiab leeg ntshav tawg tau,
cov neeg mob raum tsis ua haujlwm (kev tsis pom zoo hauv qab 30 ml / min.),
cov neeg mob mob siab tsis ua hauj lwm siab,
cov neeg mob uas muaj lub siab tsis tuaj yeem los ntshav, tshwm sim, piv txwv, los ntawm kev kho mob nrog anticoagulants lossis ntshav khov tsis zoo. Txog rau los ntshav - saib hauv seem "Kev Tshawb Nrhiav Tsis Txaus",
cov neeg mob uas muaj keeb kwm mob rwj plab thiab mob plab, cov neeg mob uas nyuam qhuav raug phais mob (kev pheej hmoo los ntshav ntau, uas yuav tsum saib xyuas hemoglobin thiab hematocrit ntau ntau)
cov neeg mob uas tau txais kev kho mob ib txhij nrog pentoxifylline thiab vitamin K kev thaiv kev tsis sib haum (saib tshooj “Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom kev sib cuam tshuam”),
cov neeg mob uas tau txais kev kho mob ib txhij nrog pentoxifylline thiab hypoglycemic agents (saib ntu "Kev cuam tshuam nrog lwm cov tshuaj thiab lwm hom kev sib cuam tshuam").

Siv thaum cev xeeb tub thiab lactation

Txij li thaum muaj kev paub tsis txaus nrog kev siv pentoxifylline hauv cov poj niam cev xeeb tub, nws yuav tsum tsis txhob raug tshuaj thaum cev xeeb tub.

Thaum lub sijhawm pub mis, pentoxifylline kis mus rau niam mis. Txawm li cas los xij, tus menyuam mos tau txais nyiaj tsawg tsawg. Yog li, nws tsis zoo li tias kev siv pentoxifylline thaum pub mis niam yog qhia tias muaj qee yam cuam tshuam rau tus menyuam.

Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem

Pentilin muaj me lossis tsis muaj kev cuam tshuam rau kev muaj peev xwm tsav lub tsheb thiab lwm yam txheej txheem. Txawm li cas los xij, hauv qee cov neeg mob nws tuaj yeem ua rau kiv taub hau, thiab yog li ntawd, txo cov tsis ncaj rau lub peev xwm ntawm lub hlwb khiav lub tsheb thiab lwm cov txheej txheem. Txog thaum tus neeg mob pom tias lawv teb li cas rau kev kho mob, lawv tsis tau qhia kom tsav tsheb lossis ua haujlwm nrog lwm cov txheej txheem.