Cov tshuaj ASK-Cardio: cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

Tshuaj Nug - Nws yog cov tshuaj tiv thaiv kev tawm tsam uas tiv thaiv platelet aggregation, thiab tseem muaj cov antipyretic, analgesic thiab anti-inflammatory nyhuv. Kev txiav tawm yog inhibited txawm tias tom qab siv cov tshuaj hauv cov koob tshuaj qis, cov nyhuv mob tsawv rau ob peb hnub tom qab noj ib koob. Enteric coated tablets yog cov qauv tshuaj uas tsis ua rau hauv plab, thiab yog li kev pheej hmoo ntawm kev sib chwv ntawm acetylsalicylic acid nrog lub plab hnyuv thiab nws qhov kev puas tsuaj yog txo qis. Kev tawg ntawm cov ntsiav tshuaj thiab kev tso tawm ntawm cov tshuaj nquag tshwm sim tsuas yog nyob hauv ib puag ncig ntawm duodenum.

Kev taw qhia rau kev siv:
Tshuaj Nug los txo kom txhob pheej hmoo:
- kev tuag rau cov neeg mob uas xav tias mob myocardial infarction,
- kev tuag rau cov neeg mob tom qab myocardial infarction,
- kev siv ischemic tawm tsam (TIA) thiab mob hlab ntsha tawg hauv cov neeg mob TIA,
- kev qoj ib ce thiab kev tuag nrog kev ruaj khov thiab tsis khov kho angina pectoris.
Tshuaj Nug kev tiv thaiv:
- mob ntsws thiab mob ntshav khov tom qab phais mob ntshav (cov leeg txhawm rau ntshav hlab plawv hlab plawv), mob carotid endarterectomy, mob ntshav hlab plawv o hla kev sib tsoo (CABG), cov leeg ntshav tsis haum),
- txoj hlab ntsws sib sib zog nqus thiab mob ntsws ntsig tom qab lub sij hawm ntev immobilization (kev phais mob tom qab phais tas),
- myocardial infarction hauv cov neeg mob uas muaj kev pheej hmoo loj ntawm kev mob plawv mob ntshav qab zib (ntshav qab zib mellitus, tswj kev mob ntshav tawm tsam) thiab cov neeg muaj ntau yam kev pheej hmoo ntawm cov kab mob plawv (hyperlipidemia, rog rog, haus luam yeeb, muaj hnub nyoog laus, thiab lwm yam).
Tshuaj Nug rau kev tiv thaiv kab mob stroke ob.

Txoj kev siv:
Cov neeg laus ib txwm muaj cai siv 1-2 ntsiav tshuaj ntawm 75 mg lossis 1 ntsiav tshuaj ntawm 150 mg rau ib hnub thaum lossis tom qab noj mov.

Ntsiav tshuaj Nug yuav tsum tau nqos tus kheej nrog dej me me.
Nrog cov kab mob myocardial infarction tsis ntev los no lossis rau cov neeg mob uas xav tias myocardial infarction: qhov tshuaj tiv thaiv thawj zaug yog 225-300 mg ntawm acetylsalicylic acid 1 zaug hauv ib hnub nyob rau hauv kom thiaj li ua tiav sai ntawm platelet sib sau. Kev noj tshuaj ntawm 300 mg rau ib hnub tuaj yeem siv rau lub sijhawm luv luv raws li kev qhia kho mob.
Chewable ntsiav tshuaj rau kev nqus sai.

Phiv los sis:
Los ntawm lub plab zom mov, dyspepsia, epigastric mob thiab mob plab yog pom, qee qhov - mob rau ntawm txoj hnyuv, kev kho mob tshwm sim ntawm kev mob voos thiab kev mob ntawm lub plab hnyuv, uas nyob rau hauv cov xwm txheej tsis tshua muaj peev xwm ua rau mob plab hnyuv taum thiab mob nrog qhov sib cuam tshuam. ntsuas ntsuas.
Vim tias cov nyhuv antiplatelet rau platelets, acetylsalicylic acid tuaj yeem ua rau muaj kev pheej hmoo los ntshav. Hemorrhages xws li mob ntshav khov, hematomas, los ntshav los ntawm qhov system genitourinary, los ntswg, los ntshav los ntawm cov pos hniav, tsis tshua mob heev los sis ntshav tsawg, los ntshav ntau yam ntxiv xws li mob plab hnyuv tawm, ntshav tawm ntawm lub hlwb (tshwj xeeb tshaj yog nyob rau cov neeg mob uas tsis muaj ntshav siab thiab / lossis nrog tib lub sijhawm kev siv tshuaj los tiv thaiv tus mob (hemostatic agents), hauv qee qhov xwm txheej tsawg, tuaj yeem muaj kev phom sij txog lub neej. Hemorrhages tuaj yeem ua rau mob ntshav qab zib ntev thiab mob ntshav qab zib / ntshav tsis muaj ntshav txaus (vim qhov sib txuas lus latent microbleeding) nrog cov chaw kuaj ntshav kuaj mob thiab cov tsos mob, xws li asthenia, pallor ntawm daim tawv nqaij, hypoperfusion.
Hauv cov neeg mob uas muaj lub cev tsis haum rau salicylates, kev tawm tsam tawv nqaij tsis haum yuav tshwm sim, suav nrog cov tsos mob xws li xoo pob, urticaria, edema, thiab khaus. Hauv cov neeg mob hawb pob, kev nce ntxiv ntawm qhov tshwm sim ntawm bronchospasm yog ua tau, kev tsis haum tshuaj los ntawm mob sib khuav mus rau qhov hnyav tuaj yeem cuam tshuam rau daim tawv nqaij, ua pa, mob plab thiab lub plawv.

Cov kev tsis haum hnyav, suav nrog kev poob siab anaphylactic, tau pom tsis tshua pom muaj. Tsis tshua muaj, hloov lub siab ua haujlwm nrog kev nce siab hauv daim siab hloov ntshav.
Kiv taub hau thiab tinnitus tau pom, uas tuaj yeem qhia txog kev noj ntau dhau.

Cov Tshuaj Tiv Thaiv:
Txoj kev tiv thaiv kom tsis txhob siv tshuaj Nug yog:
- Cov tshuaj tiv thaiv tsis haum rau cov tshuaj acetylsalicylic acid, lwm yam salicylates lossis ib feem twg ntawm cov tshuaj.
- Mob ntsws asthma ua rau muaj keeb kwm ntawm salicylates lossis NSAIDs.
- Mob ncauj plab hlaub.
- Hemorrhagic diathesis.
- Mob raum tsis ua haujlwm.
- Mob siab ua haujlwm hauv lub siab.
- Lub plawv dhia tsis zoo.
- Muab sib xyaw nrog methotrexate ntawm koob tshuaj 15 mg / vas thiv lossis ntau dua.

Cev xeeb tub
Tshuaj Nug nws tuaj yeem siv thaum cev xeeb tub nkaus xwb thaum lwm cov tshuaj tsis ua hauj lwm zoo.
Kev siv cov tshuaj salicylates nyob rau thawj lub hlis ntawm cev xeeb tub nyob rau qee qhov kev rov qab saib xyuas kabmob sib kis tau cuam tshuam nrog kev pheej hmoo ntawm kev txhim kho kabmob kev ua haujlwm (mob ua rau lub cev tawv (palatoschisis (ua rau lub plab), lub plawv tsis zoo). Txawm li cas los xij, nrog kev siv lub sijhawm ntev hauv kev siv tshuaj hauv kev kho tshuaj ntau dua 150 mg / hnub, qhov kev pheej hmoo no tau tawm mus qis: los ntawm kev tshawb nrhiav txog 32,000 tus niam-txiv niam txiv, tsis muaj kev cuam tshuam los ntawm kev siv cov tshuaj acetylsalicylic acid thiab qhov nce ntawm cov neeg muaj mob tsis zoo.
Salicylates tuaj yeem siv rau hauv kev txiav ua thawj thiab thib ob ntawm cev xeeb tub tsuas yog tom qab ntsuas qhov kev pheej hmoo / txiaj ntsig. Raws li kev kwv yees ua ntej, nrog kev siv tshuaj ntev, nws yuav tsum tsis txhob noj tshuaj acetylsalicylic acid nyob rau hauv ib koob uas ntau dua 150 mg / hnub.
Hauv lub sijhawm thib peb lub sijhawm cev xeeb tub, noj ntau dhau ntawm salicylates (ntau dua 300 mg / hnub) tuaj yeem ua rau cev xeeb tub ua rau tsis muaj zog thiab ua rau mob plab thaum yug menyuam, thiab tseem tuaj yeem ua rau cov hlab plawv mob rau lub cev (ua ntej kaw tus mob txha caj qaum) hauv menyuam yaus.
Kev siv cov tshuaj acetylsalicylic acid nyob rau hauv cov tshuaj loj sai ua ntej yug me nyuam tuaj yeem ua rau mob ntshav intracranial, tshwj xeeb tshaj yog cov me nyuam yug ntxov.

Yog li, tshwj tsis yog qee qhov xwm txheej tshwj xeeb tshaj plaws uas tau teev tseg los ntawm kev mob plawv lossis xeeb tub kev kho mob raws li kev soj ntsuam tshwj xeeb, kev siv cov tshuaj acetylsalicylic acid nyob rau lub sijhawm peb lub hlis dhau los ntawm cev xeeb tub yog contraindicated.
Acetylsalicylic acid thiab nws cov metabolites hauv ib qho me me yog tawm hauv niam cov kua mis ntawm cov pojniam muaj kua mis. Txog hnub, nrog rau kev siv luv-salicylates los ntawm cov niam, qhov pib ntawm qhov tsis xav tau nyob rau hauv cov menyuam noj niam mis tseem tsis tau tsim, raws li txoj cai, tsis tas yuav tsum tau txiav kev pub mis niam. Txawm li cas los xij, yog tias siv lub sijhawm ntev ntawm kev siv ntau kawg ntawm cov tshuaj acetylsalicylic acid, kev pub mis niam yuav tsum tsis ua haujlwm ntxiv.

Kev cuam tshuam nrog lwm cov tshuaj:
Kev siv cov tshuaj acetylsalicylic acid ib txhij nrog methotrexate nyob rau hauv koob tshuaj 15 mg / lub lis piam thiab ntau dua yog qhov cuam tshuam vim qhov nce ntawm hematological toxicity ntawm methotrexate (txo lub raum ua kom zoo ntawm methotrexate nrog cov tshuaj tiv thaiv kab mob thiab hloov chaw ntawm methotrexate nrog salicylates vim tias cov ntshav muaj protein ntau).
Kev sib xyaw ua ke kom siv nrog ceev faj:
- siv nrog methotrexate hauv kev noj tsawg dua 15 mg / vas thiv nce hematological toxicity ntawm methotrexate (txo qis hauv kev tshem tawm ntawm methotrexate nrog cov tshuaj tiv thaiv kab mob thiab hloov chaw ntawm methotrexate nrog salicylates los ntawm koom nrog plasma protein).
- kev siv tib lub sijhawm ibuprofen txwv tsis pub muaj kev cuam tshuam tsis zoo ntawm cov platelets los ntawm acetylsalicylic acid. Kev kho mob Ibuprofen rau cov neeg mob uas muaj kab mob plawv tuaj yeem txwv cov nyhuv cardioprotective ntawm acetylsalicylic acid.
- nrog rau kev siv ua ke nrog cov tshuaj thiab tshuaj anticoagulants, muaj kev pheej hmoo los ntshav ntau ntxiv. Nrog rau kev siv ntau dua ntawm cov tshuaj muaj txiaj ntsig ntawm salicylates nrog NSAIDs (vim yog qhov cuam tshuam nrog ob leeg), kev pheej hmoo ntawm mob rau sab hauv thiab lub plab zom mov nce ntxiv.
- siv tib lub sijhawm nrog uricosuric tus neeg sawv cev, xws li benzobromaron, probenecid, txo cov txiaj ntsig ntawm uric acid excretion (vim muaj kev sib tw rau kev tso zis ntawm uric acid los ntawm lub raum tubules).
- nrog rau kev siv tib lub sijhawm nrog digoxin, qhov concentration ntawm cov yav tom ntej hauv cov ntshav ntshav nce vim tias qhov ua paug txo qis raum.
- nrog rau kev siv ntau dua ntawm cov koob tshuaj acetylsalicylic acid thiab tshuaj tiv thaiv kab mob hauv lub qhov ncauj los ntawm cov pab pawg ntawm sulfonylurea lossis insulin derivatives, hypoglycemic effect ntawm tom kawg yog qhov txhim kho vim yog qhov ua rau hypoglycemic effect ntawm acetylsalicylic acid thiab kev hloov kho ntawm sulfonylurea cuam tshuam nrog plasma protein.
- tshuaj tso ntshav tso tawm ua ke nrog cov koob tshuaj ntau kawg ntawm acetylsalicylic acid txo qis glomerular pom vim qhov txo qis prostaglandin synthesis hauv lub raum.
- systemic glucocorticosteroids (tshwj tsis yog hydrocortisone) siv rau kev hloov kho rau Addison tus kab mob thaum kho nrog corticosteroids txo qis ntawm salicylates hauv cov ntshav thiab ua rau muaj kev pheej hmoo ntawm kev noj tshuaj tshaj tom qab kho.

Thaum siv nrog corticosteroids, kev pheej hmoo ntawm kev mob plab hnyuv txhaws nce ntxiv.
- xaiv cov serotonin reuptake inhibitors: kev pheej hmoo los ntshav ntau dua vim mob plab hnyuv plab vim qhov ua tau ntawm cov nyhuv synergistic.
- ACE inhibitors (ACE) nyob rau hauv kev sib xyaw nrog cov koob tshuaj acetylsalicylic acid ua rau txo qis glomerular vim qhov inhibition of vasodilator prostaglandins thiab txo cov nyhuv antihypertensive.
- nrog kev siv tib lub sij hawm nrog valproic acid, acetylsalicylic acid hloov chaw nws los ntawm nws cov kev sib txuas nrog cov ntshav plasma protein, nce ua kom muaj kuab lom rau tom kawg.
Kev haus dej cawv Ethyl ua rau muaj kev puas tsuaj rau cov leeg ntawm txoj hnyuv thiab ua kom ntev lub sijhawm los ntshav vim yog qhov sib tov ntawm acetylsalicylic acid thiab cawv.

Noj ntau dhau
Kev noj tshuaj salicylates ntau dhau yog ua tau vim mob ntev dhau los ntawm kev kho mob ntev ntev, nrog rau los ntawm kev qaug dej qaug cawv, uas yog lub neej muaj kev kub ntxhov (noj ntau dhau), thiab uas yuav tshwm sim, piv txwv li, siv los ntawm kev siv los ntawm kev siv tsis tau cov menyuam yaus lossis kev xav tshaj tawm.
Thawj cov tsos mob ntawm intoxication nrog acetylsalicylic acid yog kiv taub hau, xeev siab, ntuav, tinnitus thiab ua pa ceev, tsis txaus ntseeg. Lwm cov tsos mob kuj tau pom: tsis hnov lus, pom kev tsis meej, mob taub hau, tawm hws, mob lub cev, ua kom tsaug zog thiab rov qab zoo li, mob plab, hyperthermia, tsis meej pem. Tus mob salicylate ntev ntev tuaj yeem raug zais, vim nws cov cim thiab qhov tshwm sim tsis muaj qhov tseem ceeb.
Yog tias kev noj tshuaj ntau dua li qhov tau hais tseg, koj yuav tsum tau sab laj nrog kws kho mob tam sim ntawd, thiab yog tias muaj neeg raug tshuaj lom neeg mob sai sai koj yuav tsum tau mus rau hauv tsev kho mob.
Kev noj tshuaj ntau dhau nyob hauv cov neeg laus thiab cov menyuam yaus me (noj ntau dua li cov tshuaj pom zoo lossis raug lom lossis lom) yuav tsum muaj kev tshwj xeeb, vim tias hauv cov pab pawg ntawm cov neeg mob no tuaj yeem ua rau tuag taus.
Yog mob hnyav, muaj cov kua qaub-nyob sib npaug thiab cov dej-electrolyte tshuav muaj kev cuam tshuam (metabolic acidosis thiab lub cev qhuav dej).
Tsis muaj ib qho tshuaj tua kab mob tshwj xeeb.

Cia rau cov neeg mob:
Khaws rau hauv qhov chaw tiv thaiv los ntawm ya raws thiab lub teeb ntawm qhov kub tsis tshaj 25 ° C.
Txhob nyob ze cov me nyuam.

Daim ntawv tso tawm:
ASA - enteric coated ntsiav tshuaj, 75 mg thiab 150 mg.
Ntim: 10 lossis 15 ntsiav tshuaj hauv cov hlwv. Peb, tsib lossis rau lub hlwv ntim ntawm 10 ntsiav tshuaj txhua, ua ke nrog cov lus qhia rau kev siv rau hauv ib pob ntawm cardboard.
Rau lub blister ntim ntawm 15 ntsiav tshuaj txhua, nrog rau cov lus qhia rau siv hauv ib pob ntawm cardboard.

Muaj pes tsawg leeg:
1 ntsiav tshuajNug muaj cov tshuaj nquag: acetylsalicylic acid - 75 mg lossis 150 mg.
Cov muaj mob: cov hmoov txhuv nplej siab, crospovidone (polyplasdone XL-10), talc, microcrystalline cellulose.
Lub plhaub muaj pes tsawg leeg: Cov Khoom Uas Zoo Tshaj Plaws (hydroxypropyl methylcellulose, copovidone, polydextrose, propylene glycol, nruab nrab saw triglycerides, titanium dioxide, daj hlau oxide), Advantia Performance® (methacrylic acid-ethyl acrylate copolymer, talc, titanium dioxide, triethyl yellowite txiv kab ntxwv) , ntxim nyiam liab E 129).

Yeem:
Tshuaj Nug siv nrog ceev faj thaum muaj: kev ua siab ntev rau analgesic, anti-inflammatory, anti-rheumatic tshuaj, zoo li nyob rau hauv muaj kev tsis haum rau lwm yam tshuaj, mob rau lub plab zom mov, nrog rau keeb kwm ntawm mob ntev thiab rov ua dua lossis mob plab hnyuv, ua kom siv cov tshuaj tiv thaiv ib ce, ua rau lub raum tsis ua haujlwm thiab / los yog lub siab.
Thaum lub sijhawm siv tshuaj ntau, tus neeg mob yuav tsum sab laj nrog kws kho mob ua ntej noj ibuprofen.
Hauv cov neeg mob uas muaj kev tsis haum tshuaj, suav nrog ua rau mob ntsws asthma, ua xua rau rhinitis, urticaria, tawv nqaij ua pob, o ntawm lub caj pas thiab cov kua ntswg ua pa, nrog rau kev sib koom ua ke nrog mob ntsws ua pa thiab hauv cov neeg mob uas lub siab tsis haum rau NSAIDs kho nrog acetylsalicylic acid tej zaum kev txhim kho ntawm bronchospasm lossis ib qho kev tawm tsam ntawm bronchial hawb pob. Hauv kev phais mob (suav nrog kev kho hniav), kev siv cov khoom npaj uas muaj acetylsalicylic acid tuaj yeem ua rau muaj kev los ntshav ntau dua. Nrog rau kev noj tshuaj me me ntawm acetylsalicylic acid, cov tshuaj uric acid tawm tuaj yeem txo qis. Qhov no tuaj yeem ua rau mob gout hauv cov neeg mob uas tsis ua uric acid ntxiv.
Thaum kho nrog acetylsalicylic acid yuav tsum tsis txhob haus cawv, muab kev pheej hmoo ntawm kev puas tsuaj rau cov qog ua pa ntawm lub plab zom mov.
Tsis txhob siv cov tshuaj uas muaj cov acetylsalicylic acid rau cov menyuam yaus uas muaj tus kab mob ua pa rau lub cev tsis haum (ARVI), uas yog nrog nrog lossis tsis yog nrog los ntawm kev nce hauv lub cev kub. Txog qee cov kab mob kis, tshwj xeeb yog mob khaub thuas A, mob ua npaws B thiab mob qhua dej, nws muaj kev pheej hmoo ntawm kev tsim tus mob Reye's syndrome, uas yog ib yam mob uas tsis tshua muaj mob tab sis tuag taus uas yuav tsum tau mob sai sai. Txoj kev pheej hmoo yuav raug nce ntxiv yog tias acetylsalicylic acid siv los ua cov tshuaj concomitant, tab sis kev sib raug zoo hauv cov neeg tseem tsis tau muaj pov thawj hauv qhov no. Yog tias cov mob no nrog los ntawm ntuav ntev, qhov no yuav yog qhov qhia ntawm Reye's syndrome. Raws li cov xwm txheej saum toj no, cov menyuam yaus hnub nyoog qis dua 16 xyoo sib kis hauv kev siv tshuaj tsis muaj qhov cim tshwj xeeb (Kab mob Kawasaki).
Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab
ASA tsis cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov txheej txheem.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

ASK-cardio muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj enteric-coated: biconvex, puag ncig, dawb (10 daim ib lub hlwv, hauv ib daim ntawv thawv ntawm 1, 2, 3, 5, 6 lossis 10 pob, 30, 50, 60 lossis 100 ntsiav tshuaj hauv polymer cov kaus poom, hauv daim npav thawv ntawv 1 tuaj yeem).

Composition 1 ntsiav tshuaj:

cov tshuaj nquag: acetylsalicylic acid (ASA) - 100 mg,
Cov khoom xyaw pabcuam: cov hmoov txhuv nplej siab, stearic acid, lactose monohydrate, talc, polyvinylpyrrolidone,
enteric coating: macrogol 6000, titanium dioxide, talc, tus kws luam ntawv ntawm methacrylic acid thiab ethacrylate.

Kev ntsuas rau siv

lub siab tsis ruaj ntseg,
kev tiv thaiv kev hloov pauv ntawm cerebrovascular,
kev tiv thaiv ntawm thromboembolism ntawm lub ntsws ntawm cov leeg ntshav thiab nws cov ceg, nrog rau kev sib sib zog nqus ntawm cov leeg ntshav (piv txwv li, nrog immobility ntev ntev los ntawm kev phais mob hnyav),
kev tiv thaiv mob stroke (suav nrog cov neeg mob qog ua ntu zus),
kev tiv thaiv ntawm tus mob myocardial infarction thaum muaj ib lossis ntau qhov kev pheej hmoo (mob ntshav siab, ntshav qab zib mellitus, rog rog, hyperlipidemia, hnub nyoog laus, haus luam yeeb), kev tiv thaiv ntawm myocardial infarction,
kev tiv thaiv ntawm thromboembolism tom qab kev tsis muaj ntshav siab thiab phais vau (piv txwv li cov hlab ntsha txoj hauv kev hla kev, txoj hlab ntshav o hla kev sib tsoo, carotid artery angioplasty, carotid artery endarterectomy).

Cov Yuav Tsum Muaj

mob siab hnyav ua haujlwm
mob raum tsis ua haujlwm
hemorrhagic diathesis (kab mob voos Willebrand, hypoproteinemia, thrombocytopenic purpura, hemophilia, telangiectasia, thrombocytopenia),
mob plawv tsis ua haujlwm III-IV ua haujlwm tau zoo hauv chav kawm,
mob hnyuv los ntshav,
exacerbation ntawm erosive thiab ulcerative txhab ntawm lub gastrointestinal ib ntsuj av,
lactase deficiency, lactose intolerance, qabzib-galactose malabsorption syndrome,
bronchial hawb pob tshwm sim los ntawm kev siv cov tshuaj uas tsis yog tshuaj steroidal anti-inflammatory thiab salicylates, kev sib txuas ntawm kev rov ua dua ntawm cov hlab ntsha txhaws qhov ntswg thiab qhov ntswg, mob ntsws asthma thiab mob siab rau ASA,
cev xeeb tub lub sij hawm (thawj zaug thiab thib peb trimesters),
lub sij hawm pub niam mis,
cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo,
siv cov tshuaj methotrexate ntau kawg hauv 15 asthiv lossis ntau dua,
nce ib tug neeg mob siab rau ib qho ntawm cov tshuaj thiab lwm yam tshuaj tsis-steroidal anti-inflammatory tshuaj.

Tus txheeb ze (ASK-cardio siv nrog ceev faj):

mob me mus rau mob siab lub plawv,
mob me mus rau lub raum tsis ua haujlwm,
kab mob ua pa nyuaj,
bronchial hawb pob,
keeb kwm mob hnyuv los ntshav los yog mob tawm los ntawm cov hnyuv,
polyposis ntawm lub qhov ntswg,
quav nyab ua npaws
hyperuricemia
mob gout
Vitamin K tsis txaus
kev tsis haum tshuaj
muaj piam thaj ntau-6-phosphate dehydrogenase tsis txaus,
cev xeeb tub lub sijhawm (lub hlis thib ob),
kev txiav txim siab yav tom ntej
siv tib lub sijhawm nrog qee yam tshuaj (nrog antiplatelet, anticoagulant, lossis thrombolytic tus neeg sawv cev, ibuprofen, digoxin, methotrexate (ntawm ib koob tshuaj tsawg dua 15 mg), valproic acid, xaiv serotonin reuptake inhibitors, salicylic acid derivatives, rau kev txhaj tshuaj ntau dua) qhov ncauj tswj hwm thiab tshuaj insulin, tshuaj tsis-tshuaj steroidal tshuaj thiab dej cawv).

Tsuas tshuaj thiab tswj hwm

ASA cardio noj ntawm qhov ncauj tom qab noj mov. Cov ntsiav tshuaj tsis yog zom, ntxuav cia nrog cov kua ntau.

Lub sijhawm kho yog txiav txim los ntawm tus kws khomob tuaj koom. Raws li tus neeg sawv cev tiv thaiv kab mob, cov tshuaj yuav siv tau ntev.

Cov tshuaj pom zoo:

kev tiv thaiv ntawm mob myocardial infarction (yog tias xav tias muaj kev txhim kho nws): thawj koob tshuaj yog 100-300 mg, cov tshuaj yuav tsum tau noj sai li sai tau tom qab xav tias muaj kev txhim kho ntawm cov mob myocardial infarction tshwm sim (rau kev nqus sai, thawj ntsiav tshuaj ntawm cov tshuaj yuav tsum tau zom). Qhov kev saib xyuas txij nkawm tom qab kev txhim kho ntawm myocardial infarction yog 200-300 mg rau ib hnub rau 30 hnub,
kev tiv thaiv kab mob myocardial infarction uas tau tshwm sim thawj zaug (nyob rau ntawm qhov muaj kev pheej hmoo txaus ntshai): 100 mg ib hnub ib zaug lossis 300 mg txhua lwm hnub,
kev tiv thaiv kab mob ntsws embolism thiab nws cov ceg, nrog rau kev sib sib zog nqus ntawm cov leeg ntshav siab: 100-200 mg ib hnub lossis 300 mg txhua lwm hnub,
lwm qhov taw qhia: 100-300 mg rau ib hnub.

Sab sij huam

lub plab zom mov: feem ntau ntau - ntuav, xeev siab, mob hauv plab, kub siab, tsis tshua muaj ntshav tawm los ntawm txoj hnyuv plab, mob plab duodenal thiab mob plab (suav nrog perforated), kev ua si ntau ntawm hepatic transaminases (hloov),
kev mob plawv: tsis tshua muaj - o ntawm cov ceg, ntau cov tsos mob ntawm lub plawv tsis ua haujlwm,
hematopoietic system: mob ntshav sab hauv thiab postoperative los ntshav, los ntawm cov pos hniav los ntshav, hematomas, los ntshav los ntawm genitourinary huam, txhaws ntswg, hemorrhage nyob rau hauv lub hlwb, mob hnyav los yog mob ntshav qab zib posthemorrhagic / hlau tsis txaus, nyob rau hauv cov neeg mob uas muaj ntshav qabzib ntau-6-phosphate dehydrogenase tsis txaus thiab hemolysis
cov hlab ntsha hauv lub hauv paus: tinnitus, hnov lus tsis zoo, kiv taub hau,
cov kab mob zis: lub raum khiav tsis zoo, mob raum tsis ua haujlwm,
kev ua xua: bronchospasm, tawv nqaij ua pob khaus thiab tawm pob, rhinitis, urticaria, cardio-ua pa nyuaj siab ntsws mob, Quincke edema, o ntawm lub qhov ntswg qhov ntswg, anaphylactic kev poob siab.

Cov lus qhia tshwj xeeb

Cov tshuaj ASK-cardio yuav tsum tsuas yog siv los ntawm tus kws kho mob.

Ntawm cov koob tshuaj qis, ASA tuaj yeem ua rau gout hauv cov neeg mob ntxim nyiam.

Kev noj tshuaj ntau dua ntawm lub cev muaj qhov ua rau lub ntsej muag hypoglycemic, uas yuav tsum tau txiav txim siab thaum coj tshuaj ASA rau cov neeg mob ntshav qab zib mellitus tau txais insulin los yog tshuaj hauv lub qhov ncauj hypoglycemic.

Yog tias cov koob tshuaj ntawm ASK-cardio dhau los dhau lawm, qhov kev pheej hmoo ntawm kev mob plab hnyuv txhaws nce ntxiv.

Hauv cov neeg laus cov neeg mob, kev haus tshuaj ntau dhau yog qhov tshwj xeeb tshaj yog.

Thaum kho, kev saib xyuas yuav tsum tau ua thaum ua haujlwm ua rau cuam tshuam nrog kev mob siab thiab cov tshuaj tiv thaiv sai (tsav lub tsheb, kev ua haujlwm ntawm cov neeg tsav tsheb thiab cov xa tawm, thiab lwm yam).

Yeeb tshuaj sib cuam tshuam

Nrog kev siv tib lub sijhawm ntawm ASA-cardio, nws txhim kho cov tshuaj kho mob thiab cov kev mob tshwm sim ntawm cov tshuaj hauv qab no: methotrexate, thrombolytic, antiplatelet thiab anticoagulant tus neeg sawv cev, xaiv serotonin reuptake inhibitors, digoxin, insulin thiab qhov ncauj hypoglycemic agents, valproic acid, salicylate thiab isosporolitolop yog Cov. Yog tias nws yog qhov yuav tsum tau siv ASA ib txhij nrog cov tshuaj uas tau teev tseg, nws raug nquahu kom xav txog kev txo lawv cov koob tshuaj.

Thaum siv ua ke nrog cov koob tshuaj siab, ASA-cardio ua rau lub zog kho tsis zoo ntawm cov tshuaj hauv qab no: ib qho tshuaj diuretics, angiotensin-hloov enzyme inhibitors, uricosuric tus neeg sawv cev (probenecid, benzbromarone), cov kab mob glucocorticosteroids (tshwj tsis yog hydrocortisone, siv rau kev hloov kho ntawm Addison's disease). Yog tias nws tsim nyog siv ASA nrog rau cov tshuaj uas tau teev tseg, nws raug nquahu kom xav txog qhov teeb meem ntawm kev hloov tshuaj.

Lwm yam npaj acetylsalicylic acid

Tsuas tshuaj thiab tswj hwm

ASA cardio noj ntawm qhov ncauj tom qab noj mov. Cov ntsiav tshuaj tsis yog zom, ntxuav cia nrog cov kua ntau.

Lub sijhawm kho yog txiav txim los ntawm tus kws khomob tuaj koom. Raws li tus neeg sawv cev tiv thaiv kab mob, cov tshuaj yuav siv tau ntev.

Cov tshuaj pom zoo:

kev tiv thaiv ntawm mob myocardial infarction (yog tias xav tias muaj kev txhim kho nws): thawj koob tshuaj yog 100-300 mg, cov tshuaj yuav tsum tau noj sai li sai tau tom qab xav tias muaj kev txhim kho ntawm cov mob myocardial infarction tshwm sim (rau kev nqus sai, thawj ntsiav tshuaj ntawm cov tshuaj yuav tsum tau zom). Qhov kev saib xyuas txij nkawm tom qab kev txhim kho ntawm myocardial infarction yog 200-300 mg rau ib hnub rau 30 hnub,
kev tiv thaiv kab mob myocardial infarction uas tau tshwm sim thawj zaug (nyob rau ntawm qhov muaj kev pheej hmoo txaus ntshai): 100 mg ib hnub ib zaug lossis 300 mg txhua lwm hnub,
kev tiv thaiv kab mob ntsws embolism thiab nws cov ceg, nrog rau kev sib sib zog nqus ntawm cov leeg ntshav siab: 100-200 mg ib hnub lossis 300 mg txhua lwm hnub,
lwm qhov taw qhia: 100-300 mg rau ib hnub.

Tsis khov tsis khov taub hau,
kev tiv thaiv kev hloov pauv ntawm cerebrovascular,
kev tiv thaiv ntawm thromboembolism ntawm lub ntsws ntawm cov leeg ntshav thiab nws cov ceg, nrog rau kev sib sib zog nqus ntawm cov leeg ntshav (piv txwv li, nrog immobility ntev ntev los ntawm kev phais mob hnyav),
kev tiv thaiv mob stroke (suav nrog cov neeg mob qog ua ntu zus),
kev tiv thaiv ntawm tus mob myocardial infarction thaum muaj ib lossis ntau qhov kev pheej hmoo (mob ntshav siab, ntshav qab zib mellitus, rog rog, hyperlipidemia, hnub nyoog laus, haus luam yeeb), kev tiv thaiv ntawm myocardial infarction,
kev tiv thaiv ntawm thromboembolism tom qab kev tsis muaj ntshav siab thiab phais vau (piv txwv li cov hlab ntsha txoj hauv kev hla kev, txoj hlab ntshav o hla kev sib tsoo, carotid artery angioplasty, carotid artery endarterectomy).

Sab sij huam

Lub plab zom mov: feem ntau feem ntau - ntuav, xeev siab, mob hauv plab, kub siab, tsis tshua muaj - los ntshav los ntawm txoj hnyuv, mob plab duodenal thiab mob plab (suav nrog perforated), kev ua si ntau ntawm hepatic transaminases (hloov).

Kev kho plawv: tsis tshua muaj - o ntawm ob txhais ceg, nce cov tsos mob ntawm lub plawv tsis ua haujlwm.

Hematopoietic system: mob ntshav sab hauv thiab tom qab los ntshav, ntshav tawm ntawm cov pos hniav, hematomas, los ntshav los ntawm genitourinary plab, txhaws ntswg, hemorrhages nyob rau hauv lub hlwb, mob hnyav los yog mob ntshav qab zib / mob ntshav tsis txaus, hauv cov neeg mob uas muaj ntshav qabzib ntau-6-phosphate dehydrogenase tsis txaus - hemolytic anemia thiab.

Nruab nrab hauv lub paj hlwb: tinnitus, hnov lus, kiv taub hau.

Cov kab mob zis: mob raum khiav tsis zoo, mob raum tsis ua haujlwm.

Kev ua xua tsis haum: bronchospasm, tawv nqaij ua pob khaus thiab tawm pob, rhinitis, urticaria, cardio-ua pa nyuaj siab ntsws syndrome, Quincke's edema, o ntawm lub qhov ntswg qhov ntswg, qhov tsis txaus ntseeg anaphylactic.

Noj ntau dhau

Cov tsos mob ntawm kev tshaj tawm ntawm mob hnyav: xeev siab, ntuav, tinnitus, hnov lus tsis zoo, kiv taub hau, tsis meej pem.
Kev Kho Mob: kom tsawg dua.

Cov tsos mob ntawm kev haus dej ntau dhauthiab: ua npaws, hyperventilation, ketoacidosis, ua pa alkalosis, tsis nco qab, hlab plawv thiab ua pa tsis ua hauj lwm, mob ntshav qab zib heev.
Kev Kho Mob: tsev kho mob sai hauv tsev kho mob tshwj xeeb rau kev kho mob xwm txheej ceev - lub plab zom zaub mov, kev txiav txim siab acid-base tshuav nyiaj li cas, alkaline thiab yuam alkaline diuresis, hemodialysis, tswj hwm kev daws teeb meem, ua kom hluav ncaig hluav taws xob, siv tshuaj tua kab mob.

Kev noj tshuaj ntau ntawm ASA yog txuam nrog kev pheej hmoo ntawm cov hnyuv ntshav txhaws. Kev noj ntau tshaj yog qhov tshwj xeeb tshaj yog rau cov neeg laus.

Muaj pes tsawg leeg ib 1 ntsiav tshuaj:

yam tshuaj: acetylsalicylic acid 100 mg,
tus zam:
tub ntxhais: lactose monohydrate (mis nyuj muaj suab thaj) 15.87 mg, povidone (polyvinyl pyrrolidone) 0.16 mg, qos hmoov nplej 3.57 mg, talc 0.2 mg, stearic acid 0.2 mg
plhaub: methacrylic acid thiab ethacrylate copolymer 1: 1 (colicoate MAE 100) 4.186 mg, macrogol-6000 (high molecular phaus polyethylene glycol) 0.558 mg, talc 1.117 mg, titanium dioxide 0.139 mg.

puag ncig biconvex ntsiav tshuaj, coated nrog lub plhaub dawb. Lub ntsej muag hla ntawm cov tub ntxhais yog dawb.

Pab pawg kws tshuaj:

Cov Tshuaj Hauv Tshuaj
Acetylsalicylic acid (ASA) yog salicylic acid ester, nyob rau pawg ntawm cov tshuaj tsis-steroidal anti-inflammatory tshuaj (NSAIDs). Lub tshuab ua haujlwm ntawm kev ua yog ua raws li qhov tsis ua haujlwm ntawm lub cev tsis ua haujlwm ntawm cyclooxygenase (COX-1) enzyme, vim qhov kev sib txuas ntawm prostaglandins, prostacyclins thiab thromboxane yog thaiv. Txo cov kev sib sau ua ke, platelet adhesion thiab thrombosis los ntawm inhibiting qhov hluavtaws ntawm thromboxane A₂ hauv platelets. Nws tsub kom cov kev ua haujlwm ntawm fibrinolytic ntawm cov ntshav ntshav thiab txo qhov kev cia siab ntawm cov vitamin K-dependant coagulation yam (II, VII, IX, X). Qhov txiaj ntsig antiplatelet tshwm sim tom qab siv cov koob tshuaj me me ntawm cov tshuaj thiab mob siab rau 7 hnub tom qab siv ib zaug. Cov peev txheej ntawm ASA no tau siv rau hauv kev tiv thaiv thiab kho myocardial infarction, mob plawv, mob ntshav tawm ntawm cov leeg ntshav. ASA nyob rau hauv cov koob tshuaj siab (ntau dua 300 mg) muaj qhov tawm tsam, antipyretic thiab analgesic nyhuv.

Cov Tshuaj Pharmacokinetics
Tom qab kev tswj hwm ntawm qhov ncauj, ASA tau nrawm thiab nrawm los ntawm lub plab zom mov (GIT). ASA muab qee ntu thaum zom kom haum. Thaum lub sijhawm thiab tom qab nqus, ASA hloov mus rau hauv qhov tseem ceeb metabolite - salicylic acid, uas yog metabolized feem ntau hauv daim siab nyob rau hauv kev cuam tshuam ntawm enzymes nrog kev tsim cov metabolites xws li phenyl salicylate, glucuronide salicylate thiab salicyluric acid, uas pom nyob rau hauv ntau cov ntaub so ntswg thiab zis. Hauv cov poj niam, cov txheej txheem metabolic qeeb dua (cov haujlwm tsawg dua ntawm cov enzymes hauv cov ntshav). Qhov siab tshaj plaws ntawm ASA hauv cov ntshav ntshav tau tiav 10-20 feeb tom qab noj, salicylic acid - tom qab 0.3-2 teev. Vim tias qhov tseeb tias cov ntsiav tshuaj yog coated nrog cov kua qaub-tiv thaiv plhaub, ASA tso tawm tsis yog hauv lub plab (lub plhaub zoo txwv cov kev tshem tawm cov tshuaj hauv plab), tab sis nyob hauv thaj chaw alkaline ntawm duodenum. Yog li, qhov nqus ntawm ASA hauv daim ntawv tshuaj cov tshuaj, cov ntsiav tshuaj enteric-coated, zaj duab xis-coated, tau maj mam los ntawm 3-6 teev piv rau cov pa (tsis muaj txheej txheem) ntsiav tshuaj.
ASA thiab salicylic acid muaj zog khi rau cov ntshav plasma protein (los ntawm 66% rau 98% nyob ntawm qhov koob tshuaj) thiab muaj faib sai heev hauv lub cev. Salicylic acid hla lub tsho me me thiab zais cia nrog niam cov kua mis.
Qhov tshwj xeeb tshaj tawm ntawm salicylic acid yog koob tshuaj, vim nws cov metabolism yog txwv los ntawm lub peev xwm ntawm cov txheej txheem enzymatic. Ib nrab-lub neej yog los ntawm 2-3 teev thaum siv cov tshuaj ASA nyob rau hauv cov koob tshuaj qis thiab nce mus rau 15 teev thaum siv cov tshuaj nyob rau hauv qhov siab siab (niaj zaus noj tshuaj ntawm acetylsalicylic acid ua tshuaj loog). Tsis zoo li lwm yam salicylates, nrog kev rov ua dua ntawm cov tshuaj, tsis-hydrolyzed ASA tsis txuam nrog hauv cov ntshav cov ntshav. Salicylic acid thiab nws cov metabolites yog ua tawm los ntawm lub raum. Hauv cov neeg mob uas lub raum tsis ua haujlwm, 80-100% ntawm kev kho ib zaug rau cov tshuaj yog tawm hauv lub raum hauv 24-72 teev.

Kev ntsuas rau siv

lub siab tsis ruaj ntseg,
lub taub hau ruaj khov,
kev tiv thaiv thawj tus mob myocardial infarction nyob rau hauv lub xub ntiag ntawm kev pheej hmoo (piv txwv li, ntshav qab zib mellitus, hyperlipidemia, kub siab, rog, haus luam yeeb, laus hnub nyoog) thiab myocardial infarction,
kev tiv thaiv ntawm ischemic stroke (suav nrog rau cov neeg mob uas ua rau tsis muaj teeb meem cerebrovascular),
kev tiv thaiv kev hloov pauv ntawm cerebrovascular,
kev tiv thaiv ntawm thromboembolism tom qab kev phais mob thiab cuam tshuam cov leeg ntshav kev tiv thaiv (piv txwv li cov hlab ntshav o hla kev sib tsoo, carotid artery endarterectomy, arteriovenous shunting, carotid artery angioplasty),
kev tiv thaiv ntawm txoj hlab ntsws sib sib zog nqus thiab txoj hlab ntsws ntawm txoj hlab ntsws thiab nws cov ceg (piv txwv, nrog immobilization nyob ntev ua rau muaj kev cuam tshuam loj ntawm kev phais mob).

Siv thaum cev xeeb tub thiab thaum pub niam mis

Kev siv cov tshuaj yog contraindicated thaum cev xeeb tub (Kuv thiab III trimesters) thiab thaum pub mis. Kev siv cov ntsev loj ntawm salicylates hauv thawj 3 lub hlis ntawm cev xeeb tub yog cuam tshuam nrog kev nce ntxiv ntawm cov me nyuam hauv plab kev loj hlob tsis zoo (sib cais daim tawv, lub plawv tawg). Hauv lub hlis thib ob ntawm cev xeeb tub, salicylates tuaj yeem tsuas yog nrog kev ntsuam xyuas nruj ntawm kev pheej hmoo thiab cov txiaj ntsig.
Hauv lub sijhawm peb lub hlis dhau los ntawm cev xeeb tub, salicylates hauv kev txhaj tshuaj ntau dua (ntau dua 300 mg / hnub) ua rau lub zog ua haujlwm tsis muaj zog, lub sijhawm ntxov ntawm cov leeg ntshav ntawm tus menyuam hauv plab, nce ntshav hauv niam thiab tus menyuam, thiab kev tswj hwm tam sim ua ntej yug menyuam tuaj yeem ua rau mob ntshav khov, tshwj xeeb tshaj yog cov menyuam yug ua ntej. Lub sij hawm teem tseg ntawm salicylates hauv lub hlis peb lub hlis yog contraindicated.
Salicylates thiab lawv cov metabolites hauv cov khoom me me kis mus rau niam mis. Kev noj cov ntsev uas muaj salicylates thaum pub niam mis tsis yog nrog rau kev tshwm sim tsis zoo hauv menyuam thiab tsis tas yuav tsum txiav kev pub niam mis rau menyuam noj. Txawm li cas los xij, nrog kev siv tshuaj ntev los yog teem caij ntau dua, pub mis rau noj yuav tsum nres tam sim ntawd.

Dosage regimen, txoj kev ntawm cov thawj coj

ASA-cardio® yuav tsum noj qhov ncauj, zoo dua ua ntej noj mov, tsis tas yuav zom, haus dej kom ntau.
ASK-cardio® yog npaj rau kev siv sijhawm ntev. Lub sijhawm kho yog txiav txim los ntawm tus kws khomob tuaj koom. Thaum tsis muaj lwm yam tshuaj, nws tau raug pom zoo tias cov tshuaj hauv qab no:
Tsis Txaus Lub Kua Muag (nrog xav tias muaj tus kab mob myocardial infarction) thawj zaug ntawm 100-300 mg (thawj ntsiav tshuaj yuav tsum tau chewed rau kev nqus sai dua) yuav tsum tau noj los ntawm tus neeg mob sai li sai tau, tom qab muaj kev ua txhaum ntawm txoj kev loj hlob ntawm tus mob myocardial infarction. Hauv 30 hnub tom qab tom qab txoj kev loj hlob ntawm myocardial infarction, ib koob tshuaj ntawm 200-300 mg rau ib hnub yuav tsum tswj xyuas.
Kev tiv thaiv kab mob pob ntseg ib qho myocardial infarction thaum muaj kev pheej hmoo 100 mg rau ib hnub lossis 300 mg txhua lwm hnub.
Kev tiv thaiv ntawm myocardial infarction. Tsis khov thiab ruaj khov angina pectoris. Kev tiv thaiv ntawm ischemic mob hlab ntsha thiab hloov chaw ua haujlwm cerebrovascular. Kev tiv thaiv ntawm thromboembolism tom qab kev phais mob thiab cuam tshuam cov ntshav khov ntxiv 100-300 mg ib hnub twg.
Kev tiv thaiv ntawm txoj hlab ntsws sib sib zog nqus thiab mob txhaws ntawm txoj hlab leeg thiab nws cov ceg 100-200 mg rau ib hnub lossis 300 mg txhua lwm hnub.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog kev siv tib lub sijhawm ntawm ASA txhim kho qhov kev txiav txim ntawm cov tshuaj hauv qab no, yog tias tsim nyog, kev siv tib lub sij hawm ntawm ASA nrog rau cov npe uas tau teev tseg yuav tsum xav txog qhov yuav tsum tau txo qis cov tshuaj:
- methotrexate, vim tias qhov ua kom zoo rau lub raum thiab qhov kev txav tawm ntawm kev sib txuas lus nrog cov protein,
- nrog tib lub sij hawm siv nrog anticoagulants, thrombolytic thiab antiplatelet agents (ticlopidine, clopidogrel), muaj kev pheej hmoo ntawm ntshav los uas yog los ntawm synergism ntawm lub ntsiab kev kho mob ntawm cov tshuaj uas siv,
- nrog tib lub sij hawm siv nrog cov tshuaj nrog anticoagulant, thrombolytic los yog antiplatelet effect, muaj qhov nce ntawm kev puas tsuaj rau ntawm cov qog ua kua ntawm lub plab zom mov,
- xaiv cov serotonin reuptake inhibitors, uas tuaj yeem ua rau muaj kev pheej hmoo ntxiv los ntshav los ntawm cov hnyuv sab sauv (synergism nrog ASA),
- digoxin, vim tias nws txo qis nws lub raum kev ua haujlwm, uas tuaj yeem ua rau kom muaj kev xav ntau dhau,
- hypoglycemic cov neeg sawv cev rau kev tswj hwm qhov ncauj (sulfonylurea derivatives) thiab insulin vim muaj cov khoom hypoglycemic ntawm ASA nws tus kheej hauv kev txhaj tshuaj ntau thiab hloov ntawm sulfonylurea derivatives los ntawm lub koom haum nrog cov ntshav ntshav protein,
- nrog kev siv tib lub sijhawm nrog valproic acid, nws lub cev muaj kuab lom vim muaj kev cuam tshuam ntawm nws txoj kev txuas nrog cov ntshav plasma protein,
- NSAIDs thiab salicylic acid derivatives nyob rau hauv cov koob tshuaj ntau dua (muaj kev pheej hmoo ntawm cov nyhuv txhaws thiab los ntshav los ntawm lub plab ua haujlwm los ntawm kev ua haujlwm synergistic), thaum siv nrog ibuprofen, muaj antagonism nrog rau kev cuam tshuam tsis ua haujlwm ntawm cov ntshav plasma vim qhov ASA, uas ua rau muaj kev cuam tshuam ntawm cov hlab plawv mob Nug,
- Ethanol (nce kev pheej hmoo ntawm kev puas tsuaj rau cov qog ua kua ntawm lub plab zom mov thiab lub sijhawm ua haujlwm los ntshav ntev los ntawm kev sib nrig sib ntxiv ntawm cov teebmeem ntawm ASA thiab ethanol),
- Nrog rau kev siv tib lub sij hawm ntawm acetylsalicylic acid (raws li tus neeg sawv cev tiv thaiv kab mob) thiab blockers ntawm "qeeb" calcium channel, qhov kev pheej hmoo ntawm los ntshav nce,
- Thaum siv ib txhij nrog kub npaj, acetylsalicylic acid tuaj yeem ua rau daim siab puas.

Nrog rau kev siv tib txhij ntawm ASA nyob rau hauv cov koob tshuaj ntau, nws tsis muaj zog cov nyhuv ntawm cov tshuaj uas tau sau hauv qab no, yog tias tsim nyog, kev tswj hwm tib txhij ntawm ASA nrog cov tshuaj teev yuav tsum xav txog qhov xav tau ntawm kev hloov tshuaj ntawm cov tshuaj:
- ib qho diuretics (thaum ua ke nrog ASA hauv kev txhaj tshuaj ntau, muaj qhov txo qis ntawm glomerular pom tus nqi (GFR) vim qhov txo qis hauv cov tshuaj syntaglandins hauv ob lub raum),
- cov tshuaj tiv thaiv angiotensin hloov enzyme (ACE) (qhov tshuaj tiv thaiv txo qis hauv GFR raug pom los ntawm kev cuam tshuam ntawm prostaglandins nrog cov vasodilating effect, feem, qhov ua kom tsis muaj zog ntawm cov tshuaj tiv thaiv hypotensive.) Kev soj ntsuam txo qis hauv GFR raug pom nrog kev siv tshuaj txhua hnub ntawm ASA ntau dua 160 mg. tshuaj rau cov neeg mob rau kev kho mob ntawm lub plawv tsis ua hauj lwm.Qhov nyhuv no tseem pom thaum siv nrog ASA hauv qhov loj koob tshuaj)
- cov tshuaj nrog uricosuric kev txiav txim siab - benzbromaron, probenecid (txo cov nyhuv uricosuric vim kev sib tw ntawm kev rov qab ua haujlwm ntawm cov hlaus rov qab tso zis ua kua),,
- nrog kev siv tib lub sijhawm nrog cov kab ke glucocorticosteroids (tshwj tsis yog hydrocortisone, siv rau kev hloov kho ntawm Addison tus kab mob), muaj qhov nce ntawm kev zam ntawm salicylates thiab, raws li, ua rau lawv txoj haujlwm qaug zog.
Cov tshuaj tiv thaiv kab mob uas muaj cov tshuaj magnesium thiab / lossis aluminium qeeb qeeb thiab tsis zoo rau qhov nqus ntawm acetylsalicylic acid.

Cuam tshuam rau kev muaj peev xwm tsav tsheb, tshuab

Thaum lub sijhawm kho, qhov yuav tsum tau ceev faj thaum ua cov haujlwm uas muaj kev phom sij uas yuav tsum muaj kev mloog zoo thiab ceev ntawm lub cev kev xav (tsav tsheb, ua haujlwm nrog kev txav mus los, kev ua haujlwm ntawm tus xa khoom thiab cov neeg tsav tsheb, thiab lwm yam), raws li kiv taub hau yog ua tau.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj tau muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj - chaw tsim tshuaj paus tsis muab rau lwm daim ntawv tshuaj. Cov xim ntawm cov ntsiav tshuaj yog dawb, qhov zoo ib puag ncig, them nrog ib daim nyias nyias uas yaj hauv cov hnyuv tom qab kev tswj hwm.

ASA cardio yog ib hom tshuaj tsis-tshuaj steroidal uas muaj cov khoom ua kom zoo.

Cov ntsiav tshuaj yog nyob rau hauv blisters ntawm 10 daim. Cov blisters ua pob nrog cov duab los qhia. Txhawm rau qhov yooj yim ntawm tus neeg yuav khoom, pob khoom muaj cov hlwv txawv - 1, 2, 3, 5, 6, lossis 10 daim.

Cov ntsiav tshuaj kuj ntim rau hauv cov kaus poom ntawm cov khoom siv polymer. Cov chaw tsim khoom muab cov rwj ntim nrog cov sib txawv ntawm cov ntsiav tshuaj - 30, 50, 60 lossis 100 pieces.

Cov nyhuv pharmacological ntawm cov tshuaj yog vim yog cov tshuaj nquag, uas yog ASA (acetylsalicylic acid). Txhua ntsiav tshuaj muaj 100 mg. Txhawm rau txhawm rau txhim kho kev kho mob ntawm cov ntsiav tshuaj, ntxiv cov khoom xyaw muaj - stearic acid, polyvinylpyrrolidone, thiab lwm yam.

Pharmacological kev txiav txim

Cov tshuaj daws tau zoo nrog kev ua kom sov, muaj cov nyhuv analgesic zoo, muaj peev xwm tiv nrog platelet sib sau ua ke. Vim tias muaj cov tshuaj acetylsalicylic acid nyob rau hauv cov lus muaj pes tsawg leeg, cov tshuaj pab kom tsis txhob mob stroke thiab myocardial infarction rau cov neeg uas raug mob los ntawm kev tsis haum lub plawv tsis hnov qab pectoris.

Ib tug neeg noj tshuaj rau kev tiv thaiv txo qhov kev pheej hmoo rov qab txhim kho cov hlab plawv pathologies. Ib cov tshuaj raws li prophylactic txo txoj kev pheej hmoo ntawm cov ntshav txhaws.

Cov Tshuaj Pharmacokinetics

Nyob rau lub sijhawm luv luv, ASA tau yoog puv los ntawm txoj hnyuv, hloov mus rau hauv salicylic acid, uas yog lub cev cov khoom tseem ceeb. Cov Enzymes ua haujlwm rau cov kua qaub, yog li nws yog metabolized hauv daim siab, ua rau lwm cov metabolites, nrog rau glucuronide salicylate. Metabolites muaj nyob hauv cov zis thiab cov nqaij hauv lub cev ntau dua.

Qhov siab tshaj plaws ntawm cov tshuaj nquag hauv cov ntshav tau pom tsawg dua li ib nrab ib teev tom qab noj tshuaj.

Ib nrab-lub neej ntawm cov tshuaj nyob ntawm lub koob tshuaj. Yog tias cov tshuaj muaj ntau npaum li cas, tom qab lub sijhawm siv sijhawm ntev li 2-3 teev. Thaum noj cov tshuaj loj, lub sijhawm nce siab ntev txog 10-15 teev.