Kev ncua kev kawm rau cov menyuam Amoxiclav 125 mg: cov lus qhia rau kev siv

Zaj duab xis-cov ntsiav tshuaj 500 mg / 125 mg, 875 mg / 125 mg

Muaj ib txheej ntim yeeb yaj kiab-ntim

yam tshuaj: amoxicillin (li amoxicillin trihydrate) 500 mg thiab clavulanic acid (li potassium clavulanate) 125 mg (rau tshuaj 500 mg / 125 mg) lossis amoxicillin (li amoxicillin trihydrate) 875 mg thiab clavulanic acid (raws li potassium clavulanate) 125 mg (rau cov tshuaj ntau npaum 875 mg / 125 mg).

tus zam: colloidal silicon dioxide, crospovidone anhydrous, sodium carboxymethyl cellulose, magnesium stearate, qhuav microcrystalline cellulose.

zaj duab xis txheej muaj pes tsawg leeg: hydroxypropyl cellulose, ethyl cellulose, polysorbate, triethyl citrate, titanium dioxide (E 171), talc.

Cov ntsiav tshuaj yog coated nrog zaj duab xis daim nyias nyias ntawm cov xim dawb lossis yuav luag xim dawb, oblong, nrog ib tug bevel, sau nrog "875/125" thiab ib qho cim ntawm ib sab, thiab sau nrog "AMS" nyob rau sab nraud (rau ntau npaum ntawm 875 mg / 125 mg).

Farmacotherapeutic pab pawg

Cov tshuaj tua kab mob rau kev siv system. Tshuaj Beta-lactam tshuaj tua kab mob - Penicillins. Penicillins txuam nrog beta-lactamase inhibitors. Clavulanic acid + amoxicillin.

ATX Code J01CR02

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Amoxicillin thiab clavulanic acid yog ua kom yaj tag rau hauv kev daws teeb meem ntawm lub cev pH qhov tseem ceeb ntawm lub cev. Ob qho khoom siv tau zoo nqus tom qab kev tswj hwm ntawm qhov ncauj. Nws yog qhov zoo dua rau noj amoxicillin / clavulanic acid lub sijhawm lossis thaum pib noj mov. Tom qab kev tswj hwm ntawm qhov ncauj, lub bioavailability ntawm amoxicillin thiab clavulanic acid yog kwv yees li 70%. Lub zog puab ntawm kev saib xyuas ntawm cov tshuaj nyob rau hauv lub plasma ntawm ob feem sib xyaw zoo ib yam nkaus. Qhov siab tshaj tawm cov dej siab tau mus txog 1 teev tom qab kev tswj hwm.

Qhov ntau ntawm amoxicillin thiab clavulanic acid nyob rau hauv cov ntshav ntshav thaum noj cov tshuaj amoxicillin / clavulanic acid npaj tau zoo ib yam li qhov tau pom nrog cais lub qhov ncauj ntawm kev tswj hwm sib npaug ntawm amoxicillin thiab clavulanic acid.

Txog 25% ntawm tag nrho cov nyiaj ntawm clavulanic acid thiab 18% ntawm amoxicillin khi rau cov ntshav protein. Qhov ntim ntawm kev faib tawm rau kev tswj hwm qhov ncauj ntawm cov tshuaj yog kwv yees 0.3-0.4 l / kg ntawm amoxicillin thiab 0.2 l / kg ntawm clavulanic acid.

Tom qab kev tswj hwm kev siv tshuaj, ob qho tib si amoxicillin thiab clavulanic acid tau pom nyob hauv lub zais zis, fiber ntawm lub plab plab, tawv nqaij, rog, cov leeg nqaij, synovial thiab peritoneal kua, bile thiab pus. Amoxicillin nkag mus rau hauv lub cev tsis zoo ua kua dej.

Amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv hniav. Ob seem puav leej sib kis mus rau niam mis.

Amoxicillin yog qee cov tso tawm hauv cov zis hauv daim ntawv ntawm tsis muaj zog penicillic acid hauv qhov sib npaug ntawm 10-25% ntawm thawj koob tshuaj. Clavulanic acid yog metabolized nyob rau hauv lub cev thiab nthuav tawm hauv cov zis thiab quav, ntxiv rau hauv cov qauv ntawm cov pa roj carbon dioxide nrog cov pa tawm ntawm huab cua.

Qhov nruab nrab kev tshem tawm ib nrab-lub neej ntawm amoxicillin / clavulanic acid yog li 1 teev, thiab qhov nruab nrab tag nrho kev sib tw yog kwv yees li 25 l / teev. Li ntawm 60-70% ntawm amoxicillin thiab 40-65% ntawm clavulanic acid raug tso tawm tsis hloov pauv hauv cov zis thaum thawj 6 teev tom qab noj ib qho tshuaj amoxicillin / clavulanic acid ntsiav tshuaj. Thaum lub sij hawm ntau cov kev tshawb fawb, nws tau pom tias 50-85% ntawm amoxicillin thiab 27-60% ntawm clavulanic acid tau tawm hauv cov zis hauv 24 teev. Qhov loj tshaj plaws ntawm clavulanic acid tau tawm hauv thawj 2 teev tom qab daim ntawv thov.

Kev siv ib txhij ntawm probenecid qeeb ua rau kev tso tawm ntawm amoxicillin, tab sis cov tshuaj no tsis cuam tshuam qhov cuam tshuam ntawm clavulanic acid los ntawm ob lub raum.

Ib nrab-lub neej ntawm amoxicillin zoo ib yam li cov menyuam yaus hnub nyoog 3 hlis txog 2 xyoos, tseem yog menyuam yaus thiab neeg laus. Thaum muab tshuaj rau cov menyuam yaus me (nrog rau cov menyuam mos thaum yug los) hauv thawj lub limtiam ntawm lub neej, cov tshuaj yuav tsum tsis txhob siv ntau dua ob zaug hauv ib hnub, uas cuam tshuam nrog kev hloov lub plawv tsis ua haujlwm ntawm cov menyuam yaus. Vim tias qhov tseeb tias cov neeg laus laus yuav ua rau muaj kev mob plawv raum, Amoxiclav 2X yuav tsum siv nrog kev ceev faj hauv pawg neeg mob no, tab sis kev ua haujlwm hauv lub raum yuav tsum tau saib xyuas yog tias tsim nyog.

Tag nrho kev tshem tawm ntawm amoxicillin / clavulanic acid nyob rau hauv cov ntshav txo qis hauv cov xaim ncaj qha rau ib qho kev txo qis hauv kev ua haujlwm. Qhov txo qis ntawm amoxicillin tshem tawm yog qhov tshaj tawm piv rau clavulanic acid, txij li ntau dua ntawm amoxicillin yog tawm dhau los ntawm lub raum. Yog li, thaum muab tshuaj rau cov neeg mob uas lub raum tsis ua haujlwm, yuav tsum tau txhaj tshuaj kho kom tsis txhob muaj cov tshuaj amoxicillin ntau ntau thiab tswj cov qib clavulanic acid yuav tsum tau ua.

Thaum muab tshuaj rau cov neeg mob uas lub siab tsis ua hauj lwm zoo, yuav tsum ceev faj thaum xaiv ib koob thiab soj ntsuam daim siab ua haujlwm tas li.

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog tshuaj tua kab mob ib nrab los ntawm pawg neeg penicillin (beta-lactam tshuaj tua kab mob) uas tiv thaiv ib lossis ntau tshaj li cov enzymes (feem ntau hu ua penicillin-khi cov protein) koom nrog biosynthesis ntawm peptidoglycan, uas yog cov txheej txheem tseem ceeb ntawm cov kab mob ntawm tes ua haujlwm. Kev txwv tsis pub peptidoglycan hluavtaws ua rau kev ua haujlwm tsis zoo ntawm lub xovtooj ntawm phab ntsa, feem ntau ua raws li cov cell lysis thiab cell tuag.

Amoxicillin raug pov tseg los ntawm beta-lactamases uas ua los ntawm cov kab mob tiv taus, thiab yog li ntawd, kev ua si spectrum ntawm amoxicillin ib leeg tsis suav nrog cov kab mob me me uas tsim cov enzymes no.

Clavulanic acid yog beta-lactam kev txuam nrog penicillins. Nws inhibits qee qhov beta-lactamases, yog li tiv thaiv qhov ua tsis tiav ntawm amoxicillin, thiab nthuav nws cov kev ua haujlwm spectrum. Clavulanic acid nws tus kheej tsis muaj qhov chaw mos ua rau muaj kev cuam tshuam loj heev rau kev kho mob.

Tshaj lub sijhawm dhau los ntawm qhov kev txwv qis tshaj plaws (T> IPC) yog suav tias yog qhov kev txiav txim siab tseem ceeb ntawm cov hauj lwm zoo ntawm amoxicillin.

Ob txoj haujlwm tseem ceeb ntawm kev ua rau amoxicillin thiab clavulanic acid yog:

inactivation los ntawm cov kab mob beta-lactamases uas tsis tau txhawm los ntawm clavulanic acid, suav nrog cov chav kawm B, C thiab D.

ib qho kev hloov pauv ntawm kev sib txuas ua ke ntawm penicillin, uas txo qis kev sib raug zoo ntawm cov tshuaj tua kab mob mus rau lub hom phiaj.

Lub zog tsis haum ntawm cov kab mob lossis cov txheej txheem ntawm lub efflux twj tso kua mis (thauj cov tshuab) tuaj yeem ua rau lossis tswj qhov tsis kam ntawm cov kab mob, tshwj xeeb tshaj yog cov kab mob gram-tsis zoo.

Cov txiaj ntsig tsis pub tsawg ntawm MIC rau amoxicillin / clavulanic acid yog cov tau txiav txim siab los ntawm European Pawg Neeg Saib Xyuas Kev Tshuaj Tiv Thaiv Kev Ua Si (EUCAST).

Mechanism ntawm kev ua

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj kev ua tau zoo txaus los tiv thaiv plasmid beta-lactamases, uas feem ntau ua lub luag haujlwm tiv thaiv kab mob, thiab tsis muaj txiaj ntsig tawm tsam hom I chromosome beta-lactamases, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob rau hauv kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.

Amoxiclav muaj cov haujlwm ua cov kabmob rau cov kabmob me hauv qab no:

• Gram-positive anaerobes (Staphylococcus aureus, pneumococcus, pyogenic streptococcus, lwm hom tsiaj ntawm staphylococcus aureus thiab streptococcus, clostridia, peptococcus),
• Gram-negative anaerobes (cov kab mob Kolya, cov kab mob ntawm cov genus Enterobacter, Klebsiella, Moraxella catarilis, Bordetella, Salmonella, Shigella, Vibrio cholera).

Vim tias qee qhov kev cuam tshuam ntawm cov kab mob saum toj no tsim tawm beta-lactamase, qhov no ua rau lawv tsis raug rau Amoxicillin monotherapy.

Cov Tshuaj Pharmacokinetics

Ob qho tshuaj yeeb dej cawv tau nqus tau zoo, tsis hais txog ntawm cov khoom noj. Qhov siab tshaj plaws ntshav plasma yog nce mus txog ib teev tom qab siv tshuaj (Cmax rau amoxicillin - 3-12 μg / ml, Cmax rau clavulanic acid - 2 μg / ml.

Amoxiclav cov khoom xyaw tau zoo faib rau hauv pleural, parietal, synovial kua, bronchial secretions, nasal qhov ntswg zais cia, qaub ncaug, nrog rau cov nqaij hauv lub cev (hauv lub ntsws, palatine tonsils, nruab nrab pob ntseg, zes qe menyuam, lub tsev menyuam, lub siab, lub caj pas prostate, cov leeg ntshav, lub plab zais zis). ) Cov tshuaj tsis tuaj yeem nkag mus rau cov ntshav-lub hlwb thaiv (nrog cov tsis muaj kabmob ua paug). Nkag tau los ntawm thaj chaw placental, hauv cov kab uas muaj ntau ntxiv nrog rau niam cov kua mis. Nws khi tsis zoo rau cov ntshav plasma protein, amoxicillin trihydrate ib nrab decomposes, clavulanic acid - ua kom tiav.

Cov tshuaj no tawm los ntawm lub raum yuav luag pauv tsis tau. Me me raug tso tawm los ntawm lub ntsws thiab los ntawm cov hnyuv. Ib nrab-lub neej yog 1-1.5 teev.

Amoxicillin ua tawm los ntawm lub raum yuav luag tsis hloov pauv los ntawm tubular tso pa thiab glomerular pom. Cov zaub mov me me tuaj yeem tawm ntawm txoj hnyuv thiab lub ntsws. T1 / 2 ntawm amoxicillin thiab clavulanic acid yog 1-1.5 teev. Hauv kev mob tsis zoo hauv lub raum, nws nce rau amoxicillin txog 7,5 teev, rau clavulanic acid - txog li 4 teev. Ob qho khoom siv raug muab tshem tawm thaum lub sijhawm hemodialysis.

Kev ntsuas rau siv

Amoxiclav yog ib qho tshuaj tiv thaiv kabmob, nws yog qhov qhia rau kev kho mob kis kab mob los ntawm cov kab mob nkag rau penicillin thiab nws cov analogues:

• kis kab mob ntawm cov pa hauv nruab nrog sab saud thiab cov kabmob ENT (mob siab thiab ntev, mob sai thiab mob hlab hlwb o sai, pharyngeal abscess, tonsillitis, pharyngitis),
• cov kab mob ua pa tsawg dua (mob ntsws zoo nrog cov kab mob superinfection, mob ntsws txhaws ntev, mob ntsws),
• mob txeeb zig (piv txwv li, cystitis, urethritis, pyelonephritis),
• mob rau cov kab mob gynecology,
• kis tau ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau tsiaj thiab tib neeg tom,
• pob txha thiab mob pob txha mos,
• biliary huam mob (cholecystitis, cholangitis),
• odontogenic tau tus kab mob.

Tsuas tshuaj thiab tswj hwm

Sab hauv. Kev noj tshuaj yog tsim raws tus hnub nyoog, lub cev nyhav, tus neeg mob lub raum kev ua haujlwm thiab qhov mob hnyav tau kis.

Cov koob tshuaj txhua hnub ntawm kev ncua yog 125 mg + 31.25 mg (los txhawm rau kom zoo tshuaj, lub 5 ml kawm tiav pipette nrog 0.1 ml nplai lossis 5 ml muab tshuaj nrog cov cim annular hauv 2.5 ml kab noj hniav tau muab tso rau hauv txhua pob thiab 5 ml).

3D duab

Kev piav qhia ntawm daim ntawv tshuaj

250 + 125 mg ntsiav tshuaj: dawb los yog yuav luag dawb, oblong, octagonal, biconvex, zaj duab xis-txheej, nrog luam tawm ntawm "250/125" ntawm ib sab thiab "AMC" ntawm lwm sab.

500 + 125 mg ntsiav tshuaj: dawb lossis yuav luag dawb, oval, biconvex, zaj duab xis-txheej.

Ntsiav tshuaj 875 + 125 mg: dawb los yog yuav luag dawb, oblong, biconvex, zaj duab xis-txheej, nrog kev tshaj tawm thiab ua rau pom “875” thiab “125” ntawm ib sab thiab “AMC” ntawm lwm sab.

Saib rau ntawm kink: daj kom loj.

Hmoov rau kev tshem tawm hauv qhov ncauj: hmoov los ntawm dawb dawb mus rau daj dawb. Kev tshem tawm tiav yog ib qho kev ncua ntawm homogeneous los ntawm yuav luag dawb rau daj.

Hmoov rau qhov kev npaj ntawm kev daws rau iv tswj hwm: los ntawm dawb mus rau daj dawb.

Cov ntsiav tshuaj uas tawg: oblong, octagonal, lub teeb daj nrog ib txaws ntawm xim av, nrog tus ntxhiab tsw tsw qab.

Cov Tshuaj Hauv Tshuaj

Amoxiclav ® yog kev sib xyaw ntawm amoxicillin thiab clavulanic acid.

Amoxicillin yog semisynthetic penicillin (beta-lactam tshuaj tua kab mob) uas tiv thaiv ib los yog ntau tshaj li cov enzymes (feem ntau hu ua penicillin-khi cov protein, PSB) hauv biosynthesis ntawm peptidoglycan, uas yog kev sib txuam ntawm cov kab mob ntawm phab ntsa. Kev txwv tsis pub peptidoglycan hluavtaws ua rau ua rau lub zog ntawm phab ntsa ploj, uas feem ntau ua rau lysis thiab tuag ntawm cov hlwb microorganism.

Amoxicillin raug rhuav tshem los ntawm kev ua ntawm beta-lactamases ua los ntawm cov kab mob tiv thaiv, yog li cov kev ua si ntawm amoxicillin tsis suav nrog cov kab mob me me uas tsim cov enzymes no.

Clavulanic acid yog beta-lactam kev txuam nrog penicillins. Nws inhibits qee qhov beta-lactamases, yog li tiv thaiv qhov ua tsis tiav ntawm amoxicillin thiab nthuav nws cov spectrum ntawm kev ua, nrog rau cov kab mob uas feem ntau tiv taus amoxicillin, ntxiv rau lwm yam penicillins thiab cephalosporins. Clavulanic acid nws tus kheej tsis muaj qhov chaw mos ua rau muaj kev cuam tshuam loj heev rau kev kho mob.

Amoxiclav a muaj cov nyhuv bactericidal hauv vivo rau cov kab mob me hauv qab no:

- gram-zoo aerobes - Staphylococcus aureus *, Tus kab mob Streptococcus pneumoniae, Tus kab mob Streptococcus pyogenes,

- gram tsis zoo aerobes - Tus kab mob Enterobacter spp. **, Escherichia coli *, Haemophilus influenzae *tsiaj ntawm lub genus Klebsiella *, Moraxella catarrhalis * (Branhamella catarrhalis).

Amoxiclav a muaj cov nyhuv bactericidal hauv vitro ntawm cov kab mob me hauv qab no (txawm li cas los xij, tseem ceeb hauv chav kho mob tseem tsis tau paub meej):

- gram-zoo aerobes - Bacillis anthracis *tsiaj ntawm lub genus Corynebacterium, Enterococcus faecalis *, Enterococcus faecium *, Listeria monocytogenes, Nocardia cov hnub qubcoagulase-negative staphylococci * (suav nrog Staphylococcus epidermidis), Tus kab mob Streptococcus agalactiae, lwm hom ntawm cov genus Streptococcus, Cov kab mob Streptococcus viridans,

- gram-positive anaerobes - hom tsiaj ntawm genus Clostridiumtsiaj ntawm lub genus Peptococcustsiaj ntawm lub genus Peptostreptococcus,

- gram tsis zoo aerobes - Bordetella mob hnoos qhuavtsiaj ntawm lub genus Brucella, Gardnerella qhov chaw mos, Helicobacter pyloritsiaj ntawm lub genus Legionella, Neisseria gonorrhoeae *, Neisseria meningitidis *, Pasteurella multocida, Proteus mirabilis *, Proteus vulgaris *tsiaj ntawm lub genus Salmonella *tsiaj ntawm lub genus Shigella *, Vibrio cholerae, Yersinia enterocolitica *,

- gram-negative anaerobes - hom tsiaj ntawm genus Cov pa tshuaj (suav nrog Bacteroides fragilis), tsiaj ntawm lub genus Fusobacterium *,

- lwm yam - Borrelia burgdorferi, Chlamydia spp., Leptospira icterohaemorrhagiae, Treponema pallidum.

* Qee hom ntawm cov kab mob no ua cov beta-lactamases, uas ua rau lawv qhov tsis muaj peev xwm ua rau amoxicillin monotherapy.

** Feem ntau ntawm cov kab mob no tiv taus ntawm amoxicillin / clavulanic acid hauv vitro , txawm li cas los xij, kev kho mob kev tau txais txiaj ntsig ntawm kev sib xyaw ua ke no tau qhia txog kev kho cov mob txeeb zig uas tshwm sim los ntawm cov kab mob no.

Qhia Txog Amoxiclav ®

Rau txhua daim ntawv qhia

Cov kab mob kis tau los ntawm cov kab mob raug taus ntawm cov kab mob me me:

sab sauv ntawm txoj hlab ua pa thiab ENT kabmob (nrog rau mob siab thiab mob ntsws, mob hnyav thiab mob otitis media, pharyngeal abscess, tonsillitis, pharyngitis),

qis cov pa ua pa tawm (suav nrog kev mob ntsws zoo nrog cov kab mob superinfection, mob ntsws txhaws ntev, mob ntsws),

mob txeeb zig (e.g. cystitis, urethritis, pyelonephritis),

cov tawv nqaij thiab cov nqaij mos, nrog rau tib neeg thiab tsiaj tom,

pob txha thiab cov nqaij mos sib txuas

kua tsib lub plab (cholecystitis, cholangitis),

Rau cov hmoov ua ntej npaj ntawm kev daws rau iv kev tswj hwm

mob plab zom mov

kis kab mob sib deev (kab mob gonorrhea, mob sib chwv me me),

kev tiv thaiv kab mob tom qab kev phais.

Cov Yuav Tsum Muaj

muaj lub cev tsis haum rau lub tshuaj,

kev siv tshuaj tiv thaiv kab mob rau penicillins, cephalosporins thiab lwm yam tshuaj tua kab mob beta-lactam hauv cov anamnesis,

keeb kwm ntawm cholestatic jaundice thiab / lossis lwm lub siab ua rau lub siab ua haujlwm los ntawm kev tswj hwm ntawm amoxicillin / clavulanic acid,

mob mononucleosis thiab mob lymphocytic rau cov ntshav,

Rau cov tshuaj dispersible Amoxiclav ® Quicktab ntxiv rau

cov me nyuam qis dua 12 xyoos los hnyav dua 40 kg.

lub raum tsis ua haujlwm (Cl creatinine, mob plab zom mov, mob plab zom mov, lub raum ua haujlwm tsis txaus, cev xeeb tub, lactation, tib lub sijhawm siv nrog cov tshuaj anticoagulants.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub thiab lactation, Amoxiclav ® tsuas yog siv yog tias xav tias yuav muaj txiaj ntsig zoo rau leej niam tshaj qhov kev pheej hmoo rau tus menyuam thiab menyuam.

Amoxiclav ® Quicktab tuaj yeem siv tshuaj thaum cev xeeb tub yog tias muaj cov cim qhia meej.

Amoxicillin thiab clavulanic acid hauv ib qho me me txeem mus rau hauv niam cov kua mis.

Sab sij huam

Amoxiclav ® zaj duab xis-ntsiav tshuaj ntsiav tshuaj thiab hmoov rau qhov npaj ntawm kev daws rau iv kev tswj hwm

Los ntawm lub plab zom mov: tsis qab los noj mov, xeev siab, ntuav, raws plab, mob plab, gastritis, stomatitis, glossitis, tus nplaig "plaub hau" dub, tsaus nti txha hniav laus, hemorrhagic colitis (kuj tseem tuaj yeem tom qab kho), enterocolitis, pseudomembranous colitis, ua rau lub siab ua haujlwm tsis zoo, muaj kev ua haujlwm ntau ntxiv ALT, AST, alkaline phosphatase thiab / lossis ntshav plasma bilirubin qib, daim siab tsis ua hauj lwm (ntau zaus hauv cov neeg laus, cov txiv neej, nrog kev kho mob ntev), cholestatic jaundice, kab mob siab.

Kev tsis haum tshuaj: pruritus, urticaria, erythematous ua pob, erythema multiforme exudative, angioedema, anaphylactic shock, kev tsis haum vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, cov kab mob dav dav exanthematous pustulosis, cov tsos mob zoo ib yam li kev mob ntshav tawm, ua rau mob puas hlwb.

Los ntawm cov kab ke hemopoietic thiab cov lymphatic system: thim rov qab leukopenia (suav nrog neutropenia), mob thrombocytopenia, hemolytic anemia, thim rov qab nce hauv PV (thaum siv ua ke nrog anticoagulants), thim rov qab nyob rau lub sijhawm los ntshav, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.

Los ntawm sab hauv lub hauv nruab nrab ntawm cov hlab hlwb: kiv taub hau, mob taub hau, nriaj (tej zaum yuav tshwm sim rau cov neeg mob uas lub raum lub raum tsis ua haujlwm thaum noj tshuaj ntau).

Los ntawm cov kab mob urinary: interstitial nephritis, crystalluria, hematuria.

Lwm yam: candidiasis thiab lwm hom superinfection.

Rau cov yeeb yaj kiab-coated ntsiav tshuaj, hmoov rau tso tawm qhov ncauj, hmoov rau cov tshuaj hauv qhov ncauj ntxiv

Los ntawm sab hauv lub hauv nruab nrab ntawm cov hlab hlwb: hyperactivity. Xav tias ntxhov siab, pw tsis tsaug zog, hloov pauv tus cwj pwm, arousal.

Amoxiclav ® Quicktab thiab Amoxiclav ® hmoov rau qhov ncauj ncua

Los ntawm cov kabmob hemopoietic plab thiab kabmob lymphatic: tsis tshua muaj - thim rov qab leukopenia (suav nrog neutropenia), thrombocytopenia, tsis tshua muaj tshwm sim - eosinophilia, thrombocytosis, thim rov qab agranulocytosis, kev nce ntshav hauv lub sijhawm thiab qhov thim rov qab hauv PV, ntshav tshuaj, suav nrog reversible hemolytic anemia.

Los ntawm lub nruab zog: qhov muaj ntau zaus tsis paub txog - mob hlwb, anaphylactic kev tsis haum, kev tsis haum vasculitis, ib yam mob zoo li mob ntshav dej.

Los ntawm lub paj hlwb: ua tsis tau zoo - kiv taub hau, mob taub hau, tsis tshua muaj - insomnia, ntxhov siab, ntxhov siab vim, tus cwj pwm hloov, thim rov qab hyperactivity, pov thawj, ua tsis taus pa tuaj yeem tshwm sim rau cov neeg mob uas tsis muaj mob lub raum, nrog rau cov neeg uas tau txais siab ntau ntawm cov tshuaj.

Los ntawm cov hnyuv: feem ntau - tsis qab los noj mov, xeev siab, ntuav, raws plab. Xeev siab yog tshwm sim muaj ntau dua thaum noj cov koob tshuaj loj. Yog tias mob plab zom mov tau paub tseeb, lawv tuaj yeem tshem tawm yog tias cov tshuaj noj thaum noj mov, ua rau kis tsis tau - ua rau lub plab zom mov, tsis tshua muaj tshuaj tua kab mob nrog rau kev mob plab los ntawm cov tshuaj tua kab mob (suav nrog pseudomembranous thiab hemorrhagic colitis), tus nplaig plaub hau dub, mob plab mob plab. Hauv cov menyuam yaus, qhov pom ntawm txheej txheej ntawm txheej hniav txha hniav laus yog qhov tsis tshua pom muaj tshwm sim. Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob muaj qhov sib txawv ntawm tus hniav txha hniav laus.

Ntawm feem ntawm daim tawv nqaij: tsis haum - tawv nqaij ua pob khaus, khaus, urticaria, tsis tshua muaj - multiforme exudative erythema, tsis paub ntau zaus - Stevens-Johnson syndrome, lom ua mob rau daim tawv nqaij, ua mob rau cov tawv nqaij, ua kom tawv nqaij mob, ua rau mob ua paug, ua kom muaj mob.

Los ntawm cov kab mob urinary: tsawg kawg - crystalluria, interstitial nephritis, hematuria.

Nyob rau ib feem ntawm daim siab thiab kais plab: ua tsis tau - kev ua haujlwm ntau ntawm ALT thiab / lossis AST (qhov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob beta-lactam, tab sis nws qhov tseem ceeb hauv cov chaw kho mob tsis paub), cov xwm txheej tsis zoo los ntawm daim siab raug pom muaj feem ntau hauv cov txiv neej thiab cov neeg laus laus thiab tej zaum yuav cuam tshuam. nrog kev kho mob mus ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus.

Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, txawm li cas los xij qee zaum qee zaum lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg mob uas mob nyhav los yog cov neeg mob tau txais cov tshuaj hepatotoxic. Tsis tshua muaj heev - kev ua si ntau ntawm alkaline phosphatase, nce bilirubin, kab mob siab, mob siab daj ntseg (pom nrog kho kho nrog lwm tus penicillins thiab cephalosporins).

Lwm yam: feem ntau - candidiasis ntawm daim tawv nqaij thiab mucous daim nyias nyias, qhov zaus tsis paub meej - kev loj hlob ntawm cov kab mob insensitive.

Kev sib txuam

Rau txhua daim ntawv qhia

Antacids, glucosamine, laxatives, aminoglycosides qeeb qeeb nqus, ascorbic acid nce ntxiv nqus.

Diuretics, allopurinol, phenylbutazone, NSAIDs thiab lwm yam tshuaj thaiv cov hlab tubular tso pa tawm (probenecid) ua rau kom muaj kev cia siab ntawm amoxicillin (clavulanic acid yog tawm los ntawm glomerular pom).

Kev siv tib lub sijhawm ntawm Amoxiclav ® thiab methotrexate ntau ntxiv cov tshuaj lom ntawm methotrexate.

Qhov kev teem sijhawm ua ke nrog allopurinol ua rau muaj qhov tshwj xeeb exanthema. Txuag siv nrog disulfiram yuav tsum zam.

Txo qhov ua tau zoo ntawm cov tshuaj, thaum lub cev metabolism uas PABA tsim, ethinyl estradiol - qhov kev pheej hmoo ntawm kev so tsis los ntshav.

Cov ntawv sau piav qhia tsis tshua muaj xwm txheej ntawm kev nce INR hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias tsim nyog, siv ib txhij nrog cov tshuaj tiv thaiv kev tiv thaiv, PV lossis INR yuav tsum tau ua tib zoo saib xyuas thaum sau ntawv lossis txiav cov tshuaj.

Kev sib xyaw nrog rifampicin yog antagonistic (kev sib nrig sib tiv thaiv ntawm cov nyhuv antibacterial). Amoxiclav ® yuav tsum tsis txhob siv nyob rau hauv kev sib xyaw ua ke nrog cov tshuaj tua kab mob bacteriostatic (macrolides, tetracyclines), sulfonamides vim tias muaj peev xwm txo qis Amoxiclav effectiveness.

Amoxiclav ® txo qis kev ua tau zoo ntawm kev tiv thaiv qhov ncauj.

Rau cov ntsiav tshuaj uas siv tawg thiab cov hmoov sib xyaw rau kev ncua rau kev tswj hwm qhov ncauj ntxiv

Tsub kom muaj txiaj ntsig ntawm qhov tsis ncaj ntawm anticoagulants (suppressing lub plab hnyuv microflora, txo cov synthesis ntawm vitamin K thiab prothrombin index). Muaj qee kis, noj cov tshuaj tuaj yeem ntev dua qhov PV, hauv qhov no, kev saib xyuas yuav tsum tau noj thaum siv cov tshuaj tiv thaiv thiab cov tshuaj Amoxiclav ® Quicktab.

Probenecid txo qis kev zoo ntawm amoxicillin, ua rau muaj kev paub ntau ntxiv.

Hauv cov neeg mob tau txais mycophenolate mofetil, tom qab pib siv kev sib xyaw ntawm amoxicillin nrog clavulanic acid, qhov txo qis hauv kev ua kom muaj zog ntawm cov metabolite, mycophenolic acid, tau pom ua ntej noj cov tshuaj ntxiv ntawm kwv yees li 50%. Kev hloov pauv hauv qhov kev nkag siab no tsis tuaj yeem cuam tshuam txog cov kev hloov pauv hauv kev cuam tshuam ntawm cov mycophenolic acid.

Rau cov hmoov ua ntej npaj ntawm kev daws rau iv kev tswj hwm

Cov tshuaj tua kab mob Amoxiclav ® thiab aminoglycoside yog tshuaj tsis sib xws.

Tsis txhob sib xyaw nrog Amoxiclav ® hauv lub koob txhaj tshuaj lossis tshuaj pleev ntshav nrog lwm cov tshuaj.

Zam kev sib xyaw nrog cov kev daws teeb meem ntawm dextrose, dextran, sodium bicarbonate, nrog rau cov kev daws teeb meem uas muaj ntshav, protein, lipids.

Tsuas tshuaj thiab tswj hwm

Zaj duab xis-coated ntsiav tshuaj

Sab hauv. Kev noj tshuaj rau lub cev yog tsim tshwj xeeb, nyob ntawm seb muaj hnub nyoog, hnyav lub cev, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav npaum li cas.

Amoxiclav ® raug nquahu kom noj thaum pib noj mov kom zoo rau kev nqus thiab kom txo kev phiv los ntawm lub plab zom mov.

Lub chav kawm ntawm kev kho mob yog 5-14 hnub. Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws khomob koom nrog. Txoj kev kho yuav tsum tsis pub ntev tshaj 14 hnub yam tsis muaj kev kuaj mob zaum ob.

Cov koob tshuaj yog tshuaj raws lub hnub nyoog thiab lub cev hnyav. Cov tshuaj pom zoo kom noj yog 40 mg / kg / hnub hauv 3 koob tshuaj.

Cov menyuam yaus uas lub cev nyhav txog 40 kg lossis ntau dua yuav tsum txhaj tib yam li cov neeg laus. Rau cov menyuam yaus hnub nyoog ≤6 xyoo, nws yog qhov zoo dua los txhawm rau tshem tawm Amoxiclav a.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos (lossis> 40 kg ntawm lub cev qhov hnyav)

Cov koob tshuaj ib txwm muaj thaum mob sib khuav xwb los yog mob me yog 1 ntsiav tshuaj. 250 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 500 + 125 mg txhua 12 teev, nyob rau kis mob hnyav thiab mob ntsws ua pa - 1 rooj. 500 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 875 + 125 mg txhua 12 teev

Txij li thaum ua ke cov ntsiav tshuaj ntawm amoxicillin thiab clavulanic acid 250 + 125 mg thiab 500 + 125 mg txhua tus muaj tib cov tshuaj clavulanic acid - 125 mg, tom qab ntawd 2 ntsiav tshuaj. 250 + 125 mg tsis sib npaug rau 1 ntsiav tshuaj. 500 + 125 mg.

Dosage rau odontogenic tau tus kab mob

1 tab. 250 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 500 + 125 mg txhua 12 teev rau 5 hnub.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug coj los txiav txim siab Cl creatinine qhov tseem ceeb:

- cov neeg laus thiab menyuam yaus hnub nyoog dhau 12 xyoos (lossis ≥40 kg ntawm lub cev qhov hnyav) (cov lus. 2),

- nrog anuria, lub sijhawm nruab nrab ntawm kev txhaj tshuaj yuav tsum tau nce mus rau 48 teev lossis ntau dua,

- 875 + 125 mg ntsiav tshuaj yuav tsum tsuas yog siv rau hauv cov neeg mob nrog Cl creatinine> 30 ml / min.

Hmoov rau kev tshem tawm ntawm qhov ncauj

Kev noj hno tshuaj txhua hnub yog 125 + 31.25 mg / 5 ml thiab 250 + 62.5 mg / 5 ml (los pab txhawb kev noj kom haum, hauv txhua pob ntawm kev ncua 125 + 31.25 mg / 5 ml thiab 250 + 62.5 mg / 5 ml, 5 ml kawm tiav pipette nrog 0.1 ml nplai los yog 5 ml ntau rab diav, yog ntxig rau annular cov cim hauv kab noj hniav ntawm 2.5 thiab 5 ml).

Menyuam mos thiab menyuam muaj txog li 3 hlis - 30 mg / kg / hnub (raws li amoxicillin), muab faib ua 2 koob tshuaj (txhua 12 teev).

Kev noj tshuaj ntawm Amoxiclav ® nrog rau lub koob tshuaj - suav txog ib koob tshuaj txhawm rau kho tus mob hauv cov menyuam mos thiab menyuam hnub nyoog txog 3 hlis (Daim Ntawv 3).

Cov menyuam yaus hnub nyoog loj dua 3 hlis - los ntawm 20 mg / kg rau kev kis mob ntawm mob sib khuav me txog qib nruab nrab mus rau 40 mg / kg rau kev kis mob hnyav thiab txo qis ntawm txoj hlab pa, otitis media, sinusitis (amoxicillin) ib hnub, muab faib ua 3 koob (txhua 8 teev).

Kev noj tshuaj ntawm Amoxiclav ® nrog lub koob tshuaj pipette - suav txog ib koob tshuaj txhawm rau kho tus mob me thiab mob nyhav rau cov menyuam yaus hnub nyoog qis dua 3 hlis (raws li 20 mg / kg / hnub (rau amoxicillin) (Cov Lus 4).

Kev noj tshuaj ntawm Amoxiclav ® nrog lub koob tshuaj pipette - suav txog ib koob tshuaj kho mob rau cov menyuam muaj hnub nyoog laus dua 3 hlis (raws li 40 mg / kg / hnub (rau amoxicillin) (Cov Lus 5).

Kev noj tshuaj ntawm cov tshuaj Amoxiclav spoon nrog cov tshuaj noj me me (hauv qhov tsis nco qab cov raj xa dej) - koob tshuaj pom zoo ntawm kev ncua kev nyob ntawm lub cev qhov hnyav ntawm tus menyuam thiab qhov mob hnyav tau kis (Cov Lus 6).

Cov koob tshuaj niaj hnub raug tshem tawm 400 mg + 57 mg / 5 ml

Qhov tshuaj tau muab xam rau ib kg ntawm lub cev hnyav, nyob ntawm seb qhov mob hnyav npaum li cas. Los ntawm 25 mg / kg rau kev kis mob me me mus rau mob hnyav mus rau 45 mg / kg rau kev kis mob hnyav thiab qis ntsws ua pa, mob otitis media, sinusitis (hais txog amoxicillin) ib hnub, muab faib ua 2 koob tshuaj.

Txhawm rau kom muaj kev noj tshuaj kom zoo, ib qho kev txhaj tshuaj 400 mg + 57 mg / 5 ml raug tso rau hauv txhua pob ntawm cov raj xa dej, kawm tiav ib txhij hauv 1, 2, 3, 4, 5 ml thiab 4 qhov sib luag.

Raug tshem tawm txog 400 mg + 57 mg / 5 ml yog siv rau hauv cov menyuam yaus hnub nyoog ntau dua 3 hlis.

Qhov kev pom zoo koob tshuaj ntawm kev ncua yog nyob ntawm lub cev qhov hnyav ntawm tus menyuam thiab qhov kis tau zoo tshaj plaws

Cov koob tshuaj txhua hnub yog xam raws li lub cev qhov hnyav ntawm tus me nyuam, thiab tsis yog nws lub hnub nyoog.

Qhov koob tshuaj txhua hnub ntawm amoxicillin yog 6 g rau cov neeg laus thiab 45 mg / kg rau cov menyuam yaus.

Qhov siab tshaj plaws txhua hnub koob tshuaj clavulanic acid (hauv daim ntawv ntawm cov poov tshuaj ntsev) yog 600 mg rau cov neeg laus thiab 10 mg / kg rau cov menyuam yaus.

Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov koob tshuaj yuav tsum tau ua raws li qhov ntau tshaj plaws ntawm kev tso cai ntawm amoxicillin.

Cov neeg mob uas muaj creatinine Cl> 30 ml / min tsis tas yuav tsum tau kho ib koob.

Cov neeg laus thiab menyuam yaus hnyav dua 40 kg (qhia txog kev noj tshuaj yog siv rau kev kis mob nyav thiab mob hnyav)

Cov neeg mob nrog Cl creatinine 10-30 ml / min - 500/125 mg 2 zaug ib hnub.

Thaum Cl creatinine Cl creatinine 10-30 ml / min, koob tshuaj pom zoo yog 15 / 3.75 mg / kg 2 zaug hauv ib hnub (ntau tshaj 500/125 mg 2 zaug hauv ib hnub).

Nrog Cl creatinine iv

Cov Menyuam: nrog lub cev qhov hnyav tsawg dua 40 kg - qhov koob tshuaj yog tau txiav txim siab nyob ntawm qhov hnyav hauv lub cev.

Tsawg dua 3 lub hlis nrog lub cev hnyav dua li 4 kg - 30 mg / kg (hauv qhov tseeb ntawm tag nrho cov tshuaj Amoxiclav ®) txhua 12 teev

Hauv qab 3 lub hlis nrog lub cev qhov hnyav ntau dua 4 kg - 30 mg / kg (hauv qhov tseeb ntawm tag nrho cov tshuaj Amoxiclav ®) txhua 8 teev

Hauv cov menyuam yaus hnub nyoog qis dua 3 lub hlis, Amoxiclav ® yuav tsum tsuas yog maj mam muab Txoj kev lis ntshav dhau ntawm 30-40 feeb.

Cov menyuam muaj 3 hlis txog 12 xyoos - 30 mg / kg (hauv qhov kev npaj ntawm tag nrho Amoxiclav ®) nrog lub sijhawm 8 teev, nyob rau kis mob hnyav - nrog lub sijhawm 6 teev

Cov menyuam uas lub raum tsis ua haujlwm

Kev hloov pauv koob yog nce raws li qhov xav tau ntau tshaj ntawm amoxicillin. Rau cov neeg mob nrog Cl creatinine saum toj no 30 ml / min, kev kho tshuaj tsis tsim nyog.

Cov menyuam yaus nyhav Cl creatinine 10-30 ml / min25 mg / 5 mg rau 1 kg txhua 12 teev Cl creatinine ® muaj 25 mg ntawm amoxicillin thiab 5 mg ntawm clavulanic acid.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg - 1.2 g ntawm yeeb tshuaj (1000 + 200 mg) nrog ib ncua sijhawm ntawm 8 teev, thaum kis mob hnyav - nrog lub sijhawm ntev li 6 teev

Cov koob tshuaj tiv thaiv rau kev phais mob: 1.2 g nrog induction ntawm kev ua kom loog (nrog lub sijhawm phais tsawg dua 2 teev). Rau kev ua haujlwm ntev - 1.2 g rau 4 zaug hauv ib hnub.

Rau cov neeg mob uas lub raum tsis txaus, qhov koob tshuaj thiab / lossis qhov luv ntawm kev txhaj tshuaj ntawm cov tshuaj yuav tsum raug kho nyob ntawm seb qhov ntau ntawm tsis txaus:

Txij li 85% ntawm cov tshuaj raug tshem tawm los ntawm hemodialysis, qhov kawg ntawm txhua tus txheej txheem hemodialysis, koj yuav tsum nkag mus rau ib txwm ntawm Amoxiclav dose. Nrog peritoneal lim ntshav, kev hloov kho koob tsis tas yuav tsum.

Lub chav kawm ntawm kev kho mob yog 5-14 hnub. Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws khomob koom nrog. Nrog rau qhov txo qis hauv cov tsos mob hnyav, hloov mus rau daim ntawv ntawm Amoxiclav oral raug pom zoo kom kho cov kev kho mob txuas ntxiv.

Kev npaj ntawm kev daws rau iv txhaj. Dhuav cov ntsiab lus ntawm lub vial hauv dej rau kev txhaj tshuaj: 600 mg (500 + 100 mg) hauv 10 ml dej rau kev txhaj tshuaj lossis 1.2 g (1000 + 200 mg) hauv 20 ml dej rau kev txhaj tshuaj. Hauv / hauv nkag mus nkag qeeb (hauv 3-4 feeb).

Amoxiclav ® yuav tsum tau tswj hwm hauv 20 feeb tom qab kev npaj ntawm kev daws teeb meem rau iv cov thawj coj.

Kev npaj ntawm kev daws rau iv Txoj kev lis ntshav. Rau kev tswj hwm kev kub ntxhov ntawm Amoxiclav ®, ntxiv kev daws teeb meem yog qhov tsim nyog: npaj cov kev daws teeb meem uas muaj 600 mg (500 + 100 mg) lossis 1.2 g (1000 + 200 mg) ntawm cov tshuaj yuav tsum tau diluted hauv 50 lossis 100 ml ntawm Txoj kev lis ntshav daws, ntsig txog. Lub sijhawm ntawm Txoj kev lis ntshav yog 30-40 feeb.

Thaum siv cov kua hauv qab no hauv cov ntawv tso cai pom zoo hauv qhov kev daws teeb meem, qhov tsim nyog ntawm cov tshuaj tua kab mob tshwj xeeb tau muab khaws cia:

Kev daws ntawm cov tshuaj Amoxiclav ® tsis tuaj yeem xyaw nrog kev daws teebmeem ntawm dextrose, dextran lossis sodium bicarbonate.

Siv tib txoj kev daws teeb meem nkaus xwb. Npaj daws yuav tsum tsis txhob khov.

Sab hauv. Kev noj tshuaj yog tsim raws tus hnub nyoog, lub cev nyhav, tus neeg mob lub raum kev ua haujlwm thiab qhov mob hnyav tau kis.

Cov ntsiav tshuaj yuav tsum tau yaj nyob hauv ib nrab khob dej (tsawg kawg 30 ml) thiab sib xyaw kom huv, tom qab ntawd haus los sis tuav cov ntsiav tshuaj hauv qhov ncauj kom txog thaum yaj tag, thiab tom qab ntawd nqos.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab zom mov, cov tshuaj yuav tsum tau noj thaum pib noj mov.

Amoxiclav ® Quicktab Dispersible ntsiav tshuaj 500 mg / 125 mg:

Cov neeg laus thiab cov menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav ≥40 kg

Rau kev kho mob kis mob sib khuav ntawm me mus rau mob hnyav - 1 rooj. (500 mg / 125 mg) txhua 12 teev (2 zaug hauv ib hnub).

Rau kev kho mob ntawm kev mob hnyav thiab mob sib kis ntawm cov pa ua pa - 1 rooj. (500 mg / 125 mg) txhua 8 teev (3 zaug hauv ib hnub).

Qhov siab tshaj plaws niaj hnub noj ntawm Amoxiclav ® Quicktab yog 1,500 mg ntawm amoxicillin / 375 mg ntawm clavulanic acid.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Hauv cov neeg mob nrog creatinine Cl siab tshaj 30 ml / min, kev kho tshuaj tsis tsim nyog.

Cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav ≥40 kg (qhov qhia kev noj tshuaj yog siv rau kev kis mob nyav thiab mob hnyav):

Cov neeg laus thiab cov menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav ≥40 kg

Hauv kev mob hnyav thiab mob ua pa - 1 rooj. (875 mg / 125 mg) txhua 12 teev (2 zaug hauv ib hnub).

Cov koob tshuaj txhua hnub ntawm Amoxiclav ® Quicktab thaum siv 2 zaug hauv ib hnub yog 1750 mg ntawm amoxicillin / 250 mg ntawm clavulanic acid.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Hauv cov neeg mob nrog Cl creatinine ntau dua 30 ml / min, tsis tas yuav hloov tshuaj.

Rau cov neeg mob nrog Cl creatinine tsawg dua 30 ml / min, kev siv cov tshuaj sib kis tau ntawm cov tshuaj Amoxiclav ® Quicktab, 875 mg / 125 mg yog contraindicated.

Cov neeg mob zoo li no yuav tsum tau noj cov tshuaj ntawm kev noj tshuaj 500 mg / 125 mg tom qab tsim nyog kho qhov tsim nyog ntawm creatinine Cl.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Thaum noj cov Amoxiclav ® Quicktab, yuav tsum ceev faj. Kev tshuaj xyuas daim siab ua haujlwm yog tsim nyog. Thaum muaj kev kho mob pib nrog kev tswj hwm ntawm kev siv tshuaj, nws tuaj yeem txuas ntxiv kev kho nrog cov ntsiav tshuaj ntawm Amoxiclav ® Quicktab.

Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob koom nrog!

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub. Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Noj ntau dhau

Tsis muaj xov xwm qhia txog kev tuag lossis kev phom sij txog lub neej txoj sia vim kev siv tshuaj ntau dhau.

Cov tsos mob feem ntau, teeb meem ntawm lub plab zom mov (mob plab, raws plab, ntuav), ntxhov siab ntxhov plawv, pw tsis tsaug zog, kiv taub hau tseem muaj peev xwm, thiab nyob rau hauv cov kis mob cais ua kom qaug dab peg.

Kev Kho Mob: Yog tias muaj kev noj ntau dhau, tus neeg mob yuav tsum nyob hauv kev saib xyuas ntawm tus kws kho mob, kev kho yog mob.

Hauv kev tswj hwm tsis ntev los no (tsawg dua 4 teev) ntawm cov tshuaj, nws yog ib qho tsim nyog yuav tsum ntxuav lub plab thiab sau ntawv rau lub tshuab hluav ncaig kom txo qis nqus. Amoxicillin / potassium clavulanate raug tshem tawm los ntawm hemodialysis.

Cov lus qhia tshwj xeeb

Rau txhua daim ntawv qhia

Nrog chav kawm ntawm txoj kev kho mob, nws yog ib qhov tsim nyog los saib xyuas lub xeev ntawm txoj haujlwm ntawm cov ntshav, daim siab, thiab lub raum.

Hauv cov neeg mob uas mob raum tsis zoo, yuav tsum tau txhaj tshuaj ntau dua lossis nce ntxiv nyob nruab nrab ntawm kev txhaj tshuaj yog qhov yuav tsum tau ua.

Nws muaj peev xwm los tsim superinfection vim kev loj hlob ntawm microflora tsis raug rau nws, uas yuav tsum muaj kev hloov pauv hauv kev siv tshuaj tua kab mob.

Hauv cov neeg mob uas muaj lub siab ntsws ua rau penicillins, hla kev tsis haum nrog tshuaj tua kab mob cephalosporin yog ua tau.

Hauv cov poj niam nrog kev qias neeg ua ntej ntawm daim nyias nyias, nws tau pom tias kev kho mob prophylactic nrog amoxicillin + clavulanic acid yuav cuam tshuam nrog kev pheej hmoo ntawm necrotizing colitis hauv cov menyuam mos.

Hauv cov neeg mob nrog txo cov diuresis, cov kab mob crystalluria muaj tsawg heev. Thaum lub sijhawm siv cov tshuaj amoxicillin ntau, nws raug nquahu kom noj cov kua txaus thiab tswj cov diuresis kom txo qis qhov muaj feem ntawm kev tsim cov amoxicillin muaju.

Kev kuaj sim. Kev tso ntshav ntau ntawm amoxicillin muab qhov tsis zoo rau cov zis nyob ntawm ntshav thaum siv Benedict's reagent lossis Feling's cov tshuaj. Peb nquahu kom muaj Enzymatic tshua nrog glucosidase.

Rau cov ntsiav tshuaj uas siv tawg thiab cov hmoov sib xyaw rau kev ncua rau kev tswj hwm qhov ncauj ntxiv

Ua ntej pib txoj kev kho mob, nws yog qhov yuav tsum tau tham nrog tus neeg mob kom paub cov keeb kwm ntawm cov tshuaj tiv thaiv tsis haum rau penicillins, cephalosporins, lossis lwm yam tshuaj tua kab mob beta-lactam.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj ua ntej lossis thaum noj mov.

Thaum siv cov tshuaj tiv thaiv siab ntawm Amoxiclav ® Quiktab, cov neeg mob crystalluria yuav tsum tau hloov cov kua dej kom txaus.

Yog tias muaj kab mob ntsig txog tshuaj tua kab mob tshwm sim, tsum tsis pub Amoxiclav sai li sai tau ® Quicktab, sab laj nrog kws kho mob thiab pib kho kom tsim nyog. Cov tshuaj uas inhibit peristalsis yog contraindicated nyob rau hauv tej qhov xwm txheej.

Kev kho mob tsim nyog txuas ntxiv rau lwm 48-7 teev tom qab kev ploj ntawm cov cim kho mob ntawm tus kab mob. Nrog rau kev siv tshuaj sib luag nrog cov tshuaj estrogen uas muaj qhov ncauj tiv thaiv kab mob thiab amoxicillin, lwm txoj kev los tiv thaiv kev tiv thaiv yuav tsum tau siv yog tias ua tau.

Amoxicillin thiab clavulanic acid tuaj yeem ua rau tsis muaj kev sib txuas ntawm cov tshuaj immunoglobulins thiab albumin mus rau erythrocyte membrane, uas tuaj yeem ua kom muaj qhov tsis zoo tshwm sim nrog kev kuaj Coombs.

Kev siv cov tshuaj amoxicillin thiab clavulanic acid yog sib kis hauv kev kis mob mononucleosis, vim tias yuav ua rau pom tawm ib cov pob xoo liab.

Kev ceev faj tshwj xeeb rau kev pov tseg cov tshuaj tsis siv tshuaj. Tsis tas yuav tsum muaj kev ceev faj tshwj xeeb thaum pov tseg ntawm Amoxiclav used.

Cuam tshuam rau lub peev xwm los tsav tsheb lossis ua haujlwm uas yuav tsum muaj kev nce ceev ntawm lub cev thiab lub hlwb. Vim tias tseem yuav tsim kev phiv los ntawm lub hauv nruab nrab cov hlab hlwb, xws li kiv taub hau, mob taub hau, thiab huam, ceev faj yuav tsum tau siv thaum kho mob thaum tsav tsheb thiab lwm yam kev ua si uas yuav tsum muaj kev kub siab thiab ceev ntawm lub hlwb kev xav.

Rau cov tshuaj pleev xim zaj duab xis, cov ntsiav tshuaj dispersible, hmoov ntxiv rau qhov ncauj raug tshem tawm, ntxiv rau

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj nrog pluas noj.

Rau cov hmoov ua ntej npaj ntawm kev daws rau iv kev tswj hwm

Amoxicillin thiab clavulanic acid tuaj yeem ua rau tsis muaj kev sib txuas ntawm cov tshuaj immunoglobulins thiab albumin mus rau erythrocyte membrane, uas tuaj yeem ua rau tsis muaj tseeb kuaj Coombs.

Cov ntaub ntawv rau cov neeg mob noj cov zaub mov sodium tsawg: txhua daim 600 mg vial (500 + 100 mg) muaj 29.7 mg ntawm sodium. Txhua lub vial ntawm 1.2 g (1000 + 200 mg) muaj 59.3 mg ntawm sodium. Tus nqi ntawm cov dej qab ntsev ntau tshaj plaws hauv ib hnub ntau tshaj 200 mg.

Daim ntawv tso tawm

Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg. 15, 20 lossis 21 ntsiav tshuaj. thiab 2 desiccants (silica gel) hauv lub thawv xim liab nrog lo lus "inedible" hauv lub khob ntim tsaus nti corked nrog lub hau ntswj taub hau nrog lub nplhaib tswj nrog perforation thiab ib qho LDPE gasket sab hauv. 1 fl. hauv pob ntawv thawv.

Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg. 15 lossis 21 ntsiav tshuaj. thiab 2 desiccants (silica gel) hauv lub thawv xim liab nrog lo lus "inedible" hauv lub khob ntim tsaus nti corked nrog lub hau ntswj taub hau nrog lub nplhaib tswj nrog perforation thiab ib qho LDPE gasket sab hauv. 1 fl. hauv pob ntawv thawv.

5 lossis 7 ntsiav tshuaj. nyob rau hauv sawv hlwv ntawm varnished nyuaj txhuas / mos txhuas ntawv ci. 2, 3 lossis 4 blisters rau 5 ntsiav tshuaj. lossis 2 lub hlwv rau 7 ntsiav tshuaj. hauv pob ntawv thawv.

Cov ntsiav tshuaj ua yeeb yaj kiab, 875 mg + 125 mg. 5 lossis 7 ntsiav tshuaj. nyob rau hauv sawv hlwv ntawm varnished nyuaj txhuas / mos txhuas ntawv ci. 2 lossis 4 lub hlwv rau 5 ntsiav tshuaj. lossis 2 lub hlwv rau 7 ntsiav tshuaj. hauv pob ntawv thawv.

Hmoov rau kev tshem tawm qhov ncauj, 125 mg + 31.25 mg / 5 ml lossis 250 mg + 62.5 mg / 5 ml. Thawj lub ntim - 25 g ntawm hmoov (100 ml ntawm qhov kev tshem tawm tiav) hauv tsaus iav vial nrog lub nplhaib cim (100 ml). Lub raj mis kaw los ntawm lub hau ntswj-hau hlau nrog lub nplhaib tswj, sab hauv lub hau muaj cov roj av ua los ntawm LDPE.

Thib ob ntim - 1 fl. nrog ib rab diav tshuaj ntxiv nrog cov cim lo rau hauv kab noj hniav ntawm 2.5 thiab 5 ml (“2.5 SS” thiab “5 SS”), qhov cim ntawm qhov sau ntau tshaj 6 ml (“6 SS”) ntawm qhov siv rab diav hauv lub thawv ntawv thawv. Lossis 1 fl. ua ke nrog lub pob ntawv kawm tiav hauv pob ntawv ntawm cov duab los qhia.

Hmoov rau kev tshem tawm ntawm qhov ncauj, 400 mg + 57 mg / 5 ml. Thawj cov khoom ntim - 8.75 g (35 ml ntawm qhov kev tshem tawm tiav), 12.50 g (50 ml ntawm qhov kev tshem tawm tiav), 17.50 g (70 ml ntawm qhov kev rho tawm tiav) lossis 35.0 g (140 ml ntawm qhov kev ncua kev ua tiav) ntawm hmoov hauv lub vial cov iav dub nrog lub hau ntswj-hau ua los ntawm HDPE nrog lub nplhaib tswj thiab nrog lub gasket hauv lub hau.Los yog 17,5 g (70 ml ntawm qhov kev raug tshem tawm tiav) hauv tsaus nti vial nrog lub nplhaib cim (70 ml) nrog lub hau ntswj taub hau ua HDPE nrog lub nplhaib tswj thiab nrog lub gasket hauv lub hau.

Thib ob ntim - 1 fl. ua ke nrog lub pob ntawv kawm tiav hauv pob ntawv ntawm cov duab los qhia.

Hmoov rau kev daws rau kev tswj hwm kev siv dej, 500 mg + 100 mg lossis 1000 mg + 200 mgCov. 500 mg ntawm amoxicillin thiab 100 mg ntawm clavulanic acid lossis 1000 mg ntawm amoxicillin thiab 200 mg ntawm clavulanic acid nyob rau hauv lub khob iav uas tsis muaj kob, kaw nrog lub roj hmab nres thiab crimped aluminium cap nrog lub hau yas. 5 fl. muab tso rau hauv lub thawv ntawv thawv.

Cov ntsiav tshuaj tawg yooj yim, 500 mg + 125 mg lossis 875 mg + 125 mg. 2 ntsiav tshuaj hauv lub hlwv. 5 lossis 7 blisters muab tso rau hauv pob ntawv thawv.

Chaw tsim tshuaj paus

Xaus dd Verovshkova 57, Ljubljana, Slovenia.

Rau cov hmoov ua kev npaj ntawm kev daws rau kev tswj hwm dej ntxiv rau

1. Lek dd, Verovshkova 57, Ljubljana, Slovenia.

2. Sandoz GmbH, Biohemistrasse 10 A-6250, Kundl, Austria.

Kev thov cov neeg tau txais kev pab yuav tsum tau xa mus rau Sandoz CJSC: 125317, Moscow, Presnenskaya nab., 8, p. 1.

Xov Tooj .: (495) 660-75-09, fax: (495) 660-75-10.

Amoxiclav ®

zaj duab xis-ntsiav tshuaj 250 mg + 125 mg 250 mg + 125 - 2 xyoos.

zaj duab xis-ntsiav tshuaj 500 mg + 125 mg 500 mg + 125 - 2 xyoos.

zaj duab xis-ntsiav tshuaj 875 mg + 125 mg 875 mg + 125 - 2 xyoos.

hmoov rau qhov kev npaj daws teeb meem rau kev saib xyuas ntawm 500 mg + 100 mg 500 mg + 100 - 2 xyoos.

hmoov rau qhov kev npaj daws ntawm kev daws rau kev tswj hwm ntawm 1000 mg + 200 mg 1000 mg + 200 - 2 xyoos.

cov tshuaj dispersible 500 mg + 125 mg 500 mg + 125 - 3 xyoos.

dispersible ntsiav tshuaj 875 mg + 125 mg 875 mg + 125 - 3 xyoos.

hmoov rau kev ncua kev tswj hwm ntawm qhov ncauj 125 mg + 31.25 mg / 5 ml 125 mg + 31.25 mg / 5 - 2 xyoos. Npaj ncua kev kawm - 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 250 mg + 62.5 mg / 5 ml 250 mg + 62.5 mg / 5 - 2 xyoos. Npaj ncua kev kawm - 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 3 xyoos. Npaj ncua kev kawm - 7 hnub.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Muaj pes tsawg leeg thiab muaj lub zog ntawm Amoxiclav 125 milligrams

Amoxiclav 125 mg muaj:

1. Amoxicillin - yog hais txog penicillins uas muaj peev xwm hnov ​​mob thiab rhuav tshem ntau ntawm cov kab mob thiab kab mob txawv teb chaws.
2. Clavulanic acid yog beta-lactam, uas ua rau qeeb ntawm kev txiav txim siab ntawm cov khoom tseem ceeb thiab yog li ntawd lengthens lub sijhawm ntawm penicillin pawg tshuaj tua kab mob hauv lub cev.

Daim ntawv tso tawm thiab cov sib xyaw ntawm cov tshuaj pub rau cov neeg mob nyob rau hauv kev mob siab tshaj plaws los tiv thaiv tus kabmob, tsis xav txog kev ua phem rau lub cev. Coob tus cov kws tshaj lij hais txog cov tshuaj yog ib qho yooj yim tshaj plaws rau menyuam yaus thiab cov laus nyeem.

Cov lus qhia rau kev siv thiab daim foos tso tawm piav qhia txog Amoxiclav ntsiav tshuaj thiab Amoxiclav raug ncua (tshwj xeeb yog cov hmoov rau kev npaj qhov kev ncua).

Nthuav! Muaj amoxiclav quiktab, uas yog ib qho sai, txawm li cas los xij, nws tsuas yog muag hauv qhov ntau thiab 625 mg thiab 1000 mg.

Nrog rau kev tshwj xeeb ntawm cov tshuaj nquag, hu ua 5 ml ntawm tshuaj = 125 mg ntawm amoxicillin + 31.5 mg ntawm clavulanic acid, nws yuav pab tiv thaiv kev kis mob.

Cov lus piav qhia ntawm cov tshuaj tau lees tias cov tshuaj tua tau ntau pawg ntawm cov kab mob thiab cov kab mob me me. Feem ntau lawv hais tias Amoxiclav 125 yog rau menyuam yaus, vim nws nyob hauv daim ntawv ua kua, uas yooj yim siv.

Yuav ua li cas yug

Txhawm rau kom paub yuav ua li cas coj nws mus rau menyuam yaus, thiab tseem ceeb tshaj plaws yuav ua li cas txhawm rau amoxiclav kom raug, koj yuav tsum xa mus rau cov lus qhia rau kev siv:

1. Muab lub hwj tshuaj tua kom plam lub hmoov.
2. Ntxiv rau lub hwj dej ntshiab ua ntej rau nruab nrab ntawm lub raj mis thiab co, tom qab ntawd ntxiv dej ntau rau hauv lub raj mis, tab sis twb dhau mus txog qhov cim ntawm lub raj mis. Tom qab qhov no, co Amoxiclav raug muab ncua ntxiv.

Dilute cov tshuaj nrog 86 milliliters dej, thiab kev tshem tawm tiav rau cov menyuam yaus hauv daim ntawv qhib yog ib lub lim tiam.

Nthuav! Cov txheej txheem ntawm kev npaj ntawm kev ncua ntawv Amoxiclav 125 mg rau ib tug me nyuam ob xyoos yuav tsis txawv ntawm cov kua tshuaj tov rau ib tug menyuam ntawm 12 xyoos. Nws yog ib qho tseem ceeb rau kev laij cov tshuaj kom raug yog li kom cov kua dej muaj cov nyhuv.

Ntau npaum li cas coj

Amoxiclav raws li cov lus qhia yuav tsum coj los ntawm 5 mus rau 7 hnub, txawm li cas los xij, raws li kws kho mob tau hais tseg, koj tuaj yeem haus cov tshuaj kom ntev txog ob asthiv. Rau ntau dua 14 hnub, noj Amoxiclav 125 yuav tsis tsim nyog, vim tias qhov zoo li yuav muaj feem rau siv tshuaj yaj yeeb.

Qhov loj tshaj plaws uas yuav tsum nco ntsoov thaum noj Amoxiclav 125 mg yog tias muaj pes tsawg hnub los siv tshuaj yeeb tshuaj yuav tsum txiav txim siab los ntawm cov kws kho mob koom nrog. Kev ua txhaum ntawm cov lus qhia ntawm tus kws kho mob hauv hlwb tuaj yeem ua rau cov kev mob tshwm sim tsis zoo.