Atorvastatin-Teva yog ua los ntawm cov ntsiav tshuaj coated nrog zaj duab xis txheej: cov tshuaj ntsiav zoo li, yuav luag dawb lossis dawb, kos "93" ntawm ib sab, thiab siv cov ntawv txhaj tshuaj rau sab nraud: "7310" rau 10 mg, thiab 7310 rau 20 mg "7311", rau 40 mg - "7312", rau 80 mg - "7313" (10 pcs. Hauv cov hlwv, hauv ib daim ntawv thawv los ntawm 3 lossis 9 lub hlwv).

Composition 1 ntsiav tshuaj:

cov tshuaj nquag: atorvastatin calcium - 10.36, 20.72, 41.44 lossis 82.88 mg, uas yog sib npaug ntawm 10, 20, 40 lossis 80 mg ntawm atorvastatin,
cov khoom siv ntxiv: povidone, lactose monohydrate, eudragit (E100) (methyl methacrylate, butyl methacrylate thiab dimethylaminoethyl methacrylate copolymer), sodium stearyl fumarate, croscarmellose sodium, alpha-tocopherol macrogol succinate,
zaj duab xis txheej: opadry YS-1R-7003 hypromellose 2910 3cP (E464), polysorbate 80, hypromellose 2910 5cP (E464), macrogol 400, titanium dioxide.

Kev ntsuas rau siv

heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia, thawj hypercholesterolemia, sib xyaw (sib xyaw) hyperlipidemia (hom IIa thiab IIb raws li kev faib tawm ntawm Fredrickson) - nyob rau hauv kev sib xyaw nrog lipid-txo cov zaub mov tsim kom txo qis ntawm cov roj (cholesterol) tag nrho, cov roj lipoprotein tsawg thiab L ntxiv rau kev nce lipoprotein ntau dua cov roj (HDL),
homozygous tsev neeg hypercholesterolemia - txhawm rau kom txo cov roj (cholesterol) tag nrho thiab LDL cov roj (cholesterol), nrog tsis muaj txiaj ntsig ntawm kev noj zaub mov noj thiab lwm yam tshuaj tsis zoo ntawm kev kho mob,
txhawb cov tshuaj triglycerides (hom IV raws li Fredrickson kev faib tawm) dysbetalipoproteinemia (hom III raws li Fredrickson kev faib tawm) - yog tias tsis muaj kev noj haus zoo rau kev noj haus.

Cov Yuav Tsum Muaj

cev xeeb tub thiab lactation,
hnub nyoog txog 18 xyoo (atorvastatin qhov muaj kev nyab xeeb ntawm cov menyuam yaus thiab cov hluas tsis tau kawm),
cov kab mob ua rau lub siab ua haujlwm, nce ntxiv hauv kev ua haujlwm ntawm daim siab enzymes ntawm qhov tsis paub, tshaj qhov kev txwv siab tshaj qhov qub (VGN) los ntawm ntau dua 3 zaug,
daim siab ua rau lub siab (Cov Me Nyuam Pugh chav A thiab B),
ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Tus txheeb ze (nws yog qhov yuav tsum tau siv cov khoom nrog ceev faj):

endocrine thiab metabolic ntshawv siab,
hais electrolyte tsis txaus,
arterial hypotension,
keeb kwm ntawm daim siab mob,
tswj tsis tau tus mob vwm,
mob hnyav mob (suav nrog sepsis),
cov leeg mob pob txha,
kev raug mob, kev phais mob sab nrauv,
haus dej caw.

Tsuas tshuaj thiab tswj hwm

Atorvastatin-Teva yog siv qhov ncauj, 1 lub sijhawm nyob rau ib hnub. Noj mov tsis cuam tshuam rau qhov ua tau zoo ntawm cov tshuaj.

Thawj koob tshuaj thawj zaug, raws li txoj cai, yog 10 mg, ntsiav tshuaj tau noj txhua lub sijhawm ntawm hnub. Cov koob tshuaj yog xaiv los ntawm tus kws kho mob ib leeg zuj zus, nyob ntawm seb thawj theem ntawm cov roj cholesterol, lub hom phiaj ntawm kev kho thiab tus neeg mob cov lus teb rau kev kho. Qhov kev txhaj tshuaj txhua hnub tuaj yeem hloov los ntawm 10 txog 80 mg, nws yuav tsum raug kho nyob rau ntawm ntu 4 lossis ntau lub lis piam. Qhov siab tshaj plaws rau kev noj tshuaj txhua hnub yuav tsum tsis pub ntau tshaj 80 mg.

Thaum lub sij hawm kho, nrog qhov nce ntxiv ntawm koob tshuaj, nws yuav tsum nyob txhua 2-4 lub lis piam los saib xyuas qib ntshav lipid thiab, raws li cov ntaub ntawv tau, kho qhov koob tshuaj.

Cov tshuaj pom zoo:

homozygous tsev neeg hypercholesterolemia: 80 mg ib hnub,
heterozygous tsev neeg hypercholesterolemia: thaum pib ntawm chav kawm, noj 10 mg rau ib hnub, thaum kho txhua 4 lub lis piam qhov nce ntxiv, nqa mus rau 40 mg ib hnub twg, tau txais kev sib xyaw nrog cov tshuaj tiv thaiv cov kab mob kua tsib, thaum siv atorvastatin raws li kev siv tshuaj kho mob, qhov tshuaj tuaj yeem nce ntxiv rau qhov siab tshaj plaws cov txiaj ntsig - 80 mg ib hnub,
thawj hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia: noj 10 mg ib hnub twg, cov koob tshuaj no nyob rau hauv cov neeg mob feem ntau tso cai rau koj los muab cov kev tswj hwm ntawm lipid qib, raws li txoj cai, cov txiaj ntsig tseem ceeb pom tau 4 lub lis piam tom qab pib kev tswj hwm thiab kav ntev li siv cov tshuaj.

Hauv lub xub ntiag ntawm daim siab ua haujlwm, yog tias tsim nyog, cov koob tshuaj ntawm Atorvastatin-Teva tuaj yeem txo qis lossis nws txoj kev txais tos txais lawm. Rau cov neeg mob raum, yuav tsum tsis txhob txhaj tshuaj.

Kev kuaj xyuas kab mob plawv los yog muaj kev pheej hmoo siab heev ntawm cov kab mob plawv, nws raug nquahu tias kev kho yuav tsum tau ua nrog cov hom phiaj hauv qab no rau kev kho lipid: cov roj (cholesterol) tag nrho hauv tshooj no:

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Raws li cov ntaub ntawv muab los ntawm lub radar, Atorvastatin Teva yog tus sawv cev ntawm cov tshuaj muaj feem rau pawg ntawm statins. Cov tshuaj muaj qhov cuam tshuam ncaj qha rau enzyme reductase, ntawm uas nws yog ib qho inhibitor. Cov tshuaj muaj nyob rau hauv daim ntawv foos, txheej nrog lub plhaub los ntawm zaj duab xis tshwj xeeb, uas muab cov khoom cov xim dawb.

Nquag muaj nquag tivthaiv Atorvastatin Teva - Atorvastatin Calcium Trihydrate. Nyob ntawm seb qhov tshuaj lom ntawm cov tshuaj nquag, cov ntsiav tshuaj muaj qhov tshuaj ntau npaum li 21.7 lossis 10.85 mg. Yog tias koj hloov mus rau atorvastatin nws yog 20 thiab 10 mg, feem.

Ntxiv nrog rau cov tshuaj yeeb tshuaj tseem ceeb uas ua tau qhov ua kom zoo kho kom zoo, txhua lub ntsiav tshuaj muaj qee qhov nqi ntawm cov ntu pab. Cov no suav nrog: calcium carbonate, opadray zas, magnesium stearate, cellulose, hmoov txhuv nplej siab. Cov chaw tsim khoom ntim cov tshuaj rau hauv cov hlwv pob thiab cov thawv ntawv thawv.

Sab sij huam

Yuav luag txhua tus neeg mob tau txais kev kho mob ua ke nrog suav nrog Atorvastatin-Teva, tau hais tseg nws txoj kev tiv thaiv zoo. Txawm hais tias zoo li no, ib yam li lwm yam, cov tshuaj no muaj qee qhov kev mob tshwm sim. Los ntawm cov hnyuv dyspeptic mob (raws plab los yog cem quav, kub siab, xeev siab, ntuav, ntuav) ua rau lub plab thiab plab hnyuv tuaj yeem, ua mob rau ntawm tus txiav, mob plab tuaj yeem tshwm sim.

Los ntawm cov plab hnyuv siab raum tej zaum yuav mob myositis, myalgia, arthralgia, myopathy, rhabdomyolysis. Atorvastatin hob myopathy tuaj yeem nyuaj los ntawm kev ua haujlwm raum vim yog myoglobinuria (kev nthuav tawm ntawm cov nqaij ntawm cov nqaij hauv cov zis).

Muaj tsawg kawg uas qhov tshuaj ua rau kev tsis haum (urticaria, Quincke's edema, dermatitis, erythematous lesions).

Qee zaum ua tau kev txawj ntse puas, kev paub tsis meej ntawm lub cev, ua tsis taus kev tsaug zog thiab tsim dheev los, pom kev los sis hnov lub ntsej muag txawv txawv hauv kev xav.

Cov lus qhia rau kev siv

Ua ntej pib noj cov tshuaj Atorvastatin Teva, yam tsis muaj kev zam, txhua tus neeg mob xav tau cov zaub mov hypocholesterol. Lub hauv paus ntsiab lus ntawm khoom noj khoom haus no yuav tsum tau pom tsis yog tiv thaiv keeb kwm ntawm kev siv tshuaj yeeb, tab sis kuj thoob plaws ib sim neej. Txoj kev ua no yuav pab ua tiav lub hom phiaj tseem ceeb ntawm kev kho - LDL thiab cov roj (cholesterol) tag nrho yuav mus txog qhov tseem ceeb, thiab qib HDL yuav nce ntxiv.

Atorvastatin Teva tuaj yeem siv tsis hais lub sijhawm noj mov. Pib kho, koj yuav tsum tau txhua hli saib xyuas cov lipid profile nyob rau hauv thiaj li yuav xaiv thiab tom qab kho lub koob tshuaj ntawm cov tshuaj.

Qhov pib noj ntau zaus tsis ntau tshaj 10 mg ntawm atorvastatin ib hnub. Yog tias tsim nyog, nws tuaj yeem nqa mus rau qhov siab tshaj plaws ntawm 80 mg rau ib hnub, tuaj yeem faib ua 2 koob tshuaj (sawv ntxov thiab yav tsaus ntuj). Yog tias tus neeg mob ib txhij kho nrog cyclosporiomas, kev noj tshuaj txhua hnub ntawm Atorvastatin Teva yuav tsum muaj tsawg kawg nkaus (10 mg ib hnub twg). Kev nce siab ntawm atorvastatin nyob rau hauv cov ntshav plasma (hauv kev ua ke nrog kev hloov pauv tau zoo ntawm cov roj ntsha txhaws feem ntau) tau sau tseg 10-14 hnub tom qab pib kev kho mob.

Siv thaum cev xeeb tub

Cev xeeb tub yog qhov xwm txheej ntawm poj niam lub cev nyob rau hauv uas Atorvastatin Teva nruj me ntsis. Kev siv cov yeeb tshuaj muaj peev xwm tsuas yog thaum muaj txiaj ntsig rau leej niam outweighs qhov kev pheej hmoo rau tus niam hauv plab uas tsis tau yug. Vim tias tsis muaj cov ntaub ntawv tshawb fawb soj ntsuam seb puas yog Atorvastatin Teva kis mus rau niam mis, nws yog txwv tsis pub noj thaum nws yog ib txwm noj. Yog tias kev kho mob nrog atorvastatin tsim nyog, lactation yuav tsum tsis ua mus ntxiv.

Yog tias ib tus neeg sawv cev ntawm kev sib deev ncaj ncees tau kawm paub txog nws lub cev xeeb tub, tau pib kho nrog Atorvastatin Teva, nws txoj kev nkag yuav tsum raug tso tseg sai li sai tau. Cov poj niam noj cov tshuaj no yuav tsum saib xyuas cov neeg muaj txiaj ntsig tiv thaiv kev xeeb tub ntawm tus menyuam. Cov poj niam uas muaj hnub nyoog yug me nyuam, ua ntej pib kho nrog Atorvastatin Teva, nws raug nquahu kom tau txais kev sab laj nrog kws kho mob poj niam.

Kev siv Atorvastatin Teva yog categorically tsis pom zoo rau pawg neeg ntawm cov neeg hnub nyoog qis dua feem ntau. Qhov no yog vim muaj qhov tseeb tias kev soj ntsuam sim rau kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj hauv cov menyuam yaus tsis tau ua, yog li cov ntaub ntawv ntawm qhov no tsis muaj.

Kev cuam tshuam nrog lwm yam tshuaj

Txhawm rau tshem tawm cov kev tsis txaus siab rau lub cev, koj yuav tsum paub li cas Atorvastatin Teva cuam tshuam nrog lwm yam tshuaj. Nrog rau kev siv ua ke nrog cov tshuaj sab hauv uas muaj norethisterone thiab ethinyl estradiol (qhov ncauj txwv tsis pub muaj), lub plasma qhov siab ntawm cov tshuaj no cov tshuaj ua kom nce siab. Qhov tshwm sim no yuav tsum raug coj los txiav txim siab thaum sau tshuaj rau kev xeeb tub hauv hormonal rau cov poj niam uas xav tau kev kho mob nrog Atorvastatin Teva.

Kev tsis txaus siab cuam tshuam nrog atorvastatin thiab lwm yam statins tau pom nyob hauv cyclosporine, tshuaj antimycotic, qee cov tshuaj tua kab mob los ntawm cov pab pawg macrolide, thiab nicotinic acid. Siv cov tshuaj tsis haum nrog rau cov tshuaj yeeb dej caw ntau ua rau muaj kev cuam tshuam ntawm myopathy nrog rau tag nrho cov teeb meem cuam tshuam (rhabdomyolysis, lub raum tsis ua haujlwm).

Nrog rau kev coj ua ib txhij ntawm Atorvastatin Teva nrog digoxin, qhov kev txiav txim siab ntawm cov kab mob glycoside hauv cov ntshav ntshav nce ntxiv tsuas yog thaum siv tshuaj niaj hnub ntawm statin yog 80 mg. Yog li, hauv cov neeg mob tau txais digoxin, yuav kom zam kev glycoside intoxication, kev noj cov lipid-txo tus neeg sawv cev yuav tsum tsawg dua 80 mg rau ib hnub.

Tus nqi tshuaj

Thaum muas Atorvastatin Teva, tus nqi yog nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj nquag, nrog rau lub khw muag tshuaj qhov chaw uas yuav qhov kev yuav tshuaj. Txoj cai nqe rau cov tshuaj no tsis txawv tshwj xeeb los ntawm tus nqi ntawm cov tshuaj zoo sib xws hauv nws txoj haujlwm.

Hauv thaj chaw ntawd Lavxias teb sab Federation Tus nqi nruab nrab rau ib pob ntawm Atorvastatin Teva yog 200 rubles.
Ukrainian lub tsev muag tshuaj muab 20 mg ntsiav tshuaj ntawm tus nqi ntawm 250 UAH.

Atorvastatin-Teva cov lus piv txwv

Cov tuam txhab lag luam niaj hnub muaj los mus yuav Atorvastatin Teva analogues ntawm ob qho tib si hauv tsev thiab txawv teb chaws. Cov tshuaj no txawv hauv cov npe lag luam nkaus xwb, tab sis saib xyuas cov tshuaj muaj sia yog qhov zoo ib yam. Cov feem ntau siv tshuaj tiv thaiv ntawm Atorvastatin Teva yog Atoris, Liprimar, Tulip, Torvakard, Atomax.

Kev Siv Tshuaj Xyuas

Feem ntau tshuaj xyuas cov tshuaj, uas qhia tawm los ntawm kws kho mob thiab cov neeg mob, yog qhov zoo. Cov tib neeg uas tau siv Atorvastatin Teva tau sau tseg tias nws muaj kev tiv thaiv zoo, muaj cov nyhuv sai sai, tus yam ntxwv ntawm lub sijhawm, thiab kev txhim kho hauv qhov mob. Cov kws kho mob tsom kwm cov neeg mob uas tau kho nrog Atorvastatin Teva, hais txog nws txoj kev kho mob zoo, uas tau lees paub los ntawm cov txiaj ntsig ntawm ntau txoj kev tshawb nrhiav.

Atorvastatin Teva yog lipid-txo cov tshuaj tsim los ua kom cov lipid metabolism hauv tib neeg lub cev, thiaj li tiv thaiv nws los ntawm cov teeb meem ntawm cov roj cholesterol ntawm cov hlab ntsha ntawm cov kabmob tseem ceeb. Txawm li cas los xij, cov neeg mob yuav tsum nco ntsoov tias Atorvastatin Teva feem ntau yog cov tshuaj, kev txais tos ntawm uas yuav tsum tau pom zoo nrog tus kws kho mob tom qab kev soj ntsuam tag nrho!

Dosage daim ntawv

Coated ntsiav tshuaj, 10 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg

Ib ntsiav tshuaj muaj

cov tshuaj ua kom nquag plias - atorvastatin calcium trihydrate 10.3625 mg, 20.725 mg, 31.0875 mg, 41.450 mg, 62.175 mg, 82.900 mg, sib npaug rau atorvastatin 10 mg, 20 mg, 30 mg, 40 mg, 60 mg 80 mg,

cov neeg tsis muaj npe: microcrystalline cellulose (GR M102), anhydrous sodium carbonate, maltose, croscarmellose sodium, magnesium stearate,

zaj duab xis txheej muaj pes tsawg leeg: hypromellose (Pharmacoat Gr.606), hydroxypropyl cellulose, triethyl citrate, polysorbate 80, titanium dioxide (E 171).

Cov ntsiav tshuaj yog coated nrog lub plhaub los ntawm dawb mus rau yuav luag dawb, oval, nrog lub ntsej muag biconvex (rau cov koob tshuaj 10 mg, 20 mg, 40 mg, 80 mg).

Cov ntsiav tshuaj yog coated nrog lub plhaub los ntawm dawb mus rau yuav luag dawb, oval, nrog thaj chaw biconvex thiab cim "30" ntawm ib sab (rau ntau npaum li 30 mg).

Cov ntsiav tshuaj yog coated nrog lub plhaub los ntawm dawb mus rau yuav luag dawb, oval, nrog thaj chaw biconvex thiab cim "60" ntawm ib sab (rau ntau npaum ntawm 60 mg).

Cov chaw muag tshuaj

Tom qab kev tswj hwm ntawm qhov ncauj, atorvastatin nrawm nrawm. Qhov siab tshaj plaws yog ua tiav tom qab 1-2 teev. Kev nqus tau nce ntxiv hauv kev sib luag nrog cov koob tshuaj. Vim yog lub presystemic tshem tawm hauv cov qog ua pa ntawm txoj hnyuv thiab cov txiaj ntsig ntawm "thawj txoj kab" los ntawm daim siab, lub cev tsis txaus siab ntawm atorvastatin yog 12%, thiab cov kev ua haujlwm ntawm lub cev ua haujlwm yog 30%. Qhov nruab nrab ntim ntawm faib ntawm atorvastatin yog li 381 litres. Kev khi rau cov ntshav plasma protein - 98%. Atorvastatin nquag txhim kho los ntawm cytochrome P450 nrog kev tsim ortho- thiab para-hydroxylated derivatives thiab ntau yam khoom ntawm beta oxidation. Cov kev tiv thaiv kev ua haujlwm tiv thaiv HMG-CoA reductase hauv plasma yog kwv yees li 70% vim yog cov tshuaj tiv thaiv metabolites. Atorvastatin thiab nws cov khoom ua kom lub cev txhaws tas nrog cov kua tsib tom qab cov kab mob hepatic thiab extrahepatic. Ib nrab-lub neej ntawm atorvastatin yog 14 teev. Lub sijhawm ib nrab ntawm lub neej nyob ntawm qhov kev ua kom tsis zoo ntawm HMG-CoA reductase yog 20-30 teev vim muaj cov metabolites nquag.

Hauv cov neeg mob laus, qhov concentration ntawm atorvastatin hauv ntshav yuav ntau dua.

Thaum lub cev ua haujlwm tsis zoo, cov tshuaj atorvastatin thiab cov metabolites nce ntxiv 16 zaug.

Lub tshuab ua haujlwm ntawm cov kev coj ua cuam tshuam nrog kev ua txhaum ntawm kev sib txuas ntawm cov roj (cholesterol) hauv lub siab nyob rau ntawm mevalonic acid theem vim kev xaiv sib tw inhibition ntawm HMG-CoA reductase. Atorvastatin txo cov ntshav plasma cov ntshav thiab lipoprotein ntau vim qhov teeb meem hepatic cholesterol synthesis thiab nce tus lej thiab kev ua haujlwm ntawm hepatic low density lipoprotein receptors (LDL) ntawm lub ntsej muag ntawm tes, uas ua rau muaj kev nce siab thiab catabolism ntawm LDL. Atorvastatin ua tau zoo txo qis LDL ntau ntau hauv cov neeg mob homozygous kab mob hypercholesterolemia uas feem ntau tsis teb rau kev kho lipid-txo qis. Kev txo qis hauv qhov LDL txo qis kev pheej hmoo ntawm kev muaj mob ntawm cov mob plawv.

Tsuas tshuaj thiab tswj hwm

Ua ntej pib kev kho mob, koj yuav tsum sim ua kom tiav kev tswj hwm ntawm hypercholesterolemia los ntawm kev noj haus, kev tawm dag zog thiab kev poob phaus hauv cov neeg mob rog, nrog rau kev kho mob ntawm lwm tus kab mob.Thaum muab tshuaj rau, cov neeg mob yuav tsum pom zoo rau kev noj zaub mov hypocholesterolemic noj, uas nws yuav tsum tau ua raws thaum lub sijhawm kho.

Cov tshuaj yog npaum li cas nyob rau txhua lub sijhawm ntawm hnub, tsis hais noj zaub mov noj. Cov koob tshuaj ntawm cov tshuaj yog xaiv los ntawm 10 txog 80 mg ib hnub ib zaug, noj mus rau hauv tus account thawj cov ntsiab lus ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib tus zuj zus. Thaum pib kho thiab / lossis thaum qhov nce ntxiv ntawm cov tshuaj, nws yog qhov yuav tsum tau saib xyuas cov ntshav lipid cov ntsiab lus nyob rau txhua 2-4 lub lis piam thiab kho qhov tshuaj yog tsim nyog.

Thawj hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia: rau feem ntau cov neeg mob - 10 mg ib hnub ib zaug, kev kho mob tshwm sim nws tus kheej tsis pub dhau 2 lub lis piam thiab feem ntau nce mus txog qhov siab tshaj plaws nyob rau hauv 4 lub lis piam, nrog kev kho mob ntev, cov nyhuv txuas ntxiv.

Homozygous tsev neeg hypercholesterolemia: 80 mg ib hnub ib zaug (feem ntau, txoj kev kho tau coj cov ntsiab lus ntawm LDL-C los ntawm 18-45%).

Dlaim ntshav mob hnyav: qhov kev xav kom pib yog 10 mg ib hnub ib zaug. Cov koob tshuaj yuav raug nce ntxiv mus rau 80 mg ib hnub nyob rau hauv raws li cov chaw kuaj mob teb thiab kam rau ua. Cov koob tshuaj yuav tsum tau xaiv ib tus kheej coj mus rau hauv tus account lub hom phiaj pom zoo ntawm kev kho mob.

Siv rau hauv cov neeg mob uas muaj kab mob siab: saib. "Contraindications."

Kev noj tshuaj rau cov neeg mob lub raum tsis ua haujlwm: lub raum tsis cuam tshuam qhov tshuaj ntawm Atorvastatin-Teva hauv ntshav lossis qhov siab ntawm qhov txo qis hauv LDL-C cov ntsiab lus, yog li ntawd, kev txhaj tshuaj rau cov tshuaj tsis tas yuav tsum tau ua.

Daim ntawv thov hauv cov neeg laus: tsis muaj qhov sib txawv hauv kev nyab xeeb, kev ua tau zoo, lossis kev ua tiav ntawm lub hom phiaj ntawm kev kho lipid-txo qis hauv cov neeg laus piv nrog cov pej xeem.

Atorvastatin-Teva - cov cuab yeej niaj hnub rau kev txo cov roj (cholesterol)

Atorvastatin-Teva yog cov tshuaj uas pab cov neeg mob ntshav siab uas muaj plaque ntawm lawv cov hlab ntsha. Kev tshuaj xyuas ntawm cov kws kho mob tau hais tias qhov no yog tiam neeg tshiab ntawm cov tshuaj, los ntawm synthetically.

Yuav noj cov tshuaj roj Atorvastatin-Teva li cas?

Cov tshuaj yog rau cov pab pawg ntawm statins, tab sis qhia kev ua tau zoo dua li cov tshuaj zoo sib xws.

Lub ntsej muag ntawm Atorvastatin-Teva yog qhov tseem ceeb txwv rau kev coj noj coj ua nrog lwm cov tshuaj.

Cov lus qhia rau kev siv tshuaj rau cov roj cholesterol muaj cov ntaub ntawv hais txog cov cim thiab cov yam ntxwv ntawm kev ua. Ib yam tshuaj uas tau qhia hauv daim ntawv ntawm cov ntsiav tshuaj, thaum cov roj cholesterol pib tsim kev hem thawj rau tus neeg mob txoj kev noj qab haus huv, ua rau muaj kev tiv thaiv ntau yam kab mob. Atorvastatin ntsiav tshuaj yog kws kho thaum muaj cov cim qhia txog kev siv:

kab mob ntawm cov hlab plawv mob tuaj yeem tshwm sim los ntawm caj ces thiab lub hnub nyoog cuam tshuam txog lub neej tsis zoo, kev ua neej tsis raug, kev haus dej haus cawv thiab haus luam yeeb,
ntshav siab
myocardial infarction thiab mob stroke,
rov pw tsev kho mob tshwm sim los ntawm angina pectoris,
thawj thiab muaj keeb hypercholesterolemia,
qhov xav tau los ntxiv cov zaub mov tshwj xeeb kev noj zaub mov noj muaj txiaj ntsig rau hyperlipidemia, dysbetalinoproteinemia, hypertriglyceridemia.

Cov roj cholesterol hauv cov kab mob no ua rau ib tug neeg, nce qhov kev pheej hmoo sai sai los ntawm cov teeb meem. Lub tshuab ntawm kev txiav txim ntawm cov tshuaj yog tswj kev ua kom tsis haum tshuaj xws li HMG-CoA reductase, tig nws lub ntsiab tseem ceeb 3-hydroxy-3-methylglutarin-CoA rau hauv mevalonic acid. Raws li qhov tshwm sim, lipoproteins tsawg ntom pib tsim, uas pab txo kev pheej hmoo ntawm kev tsim cov kab mob plawv, atherosclerosis, thiab txo cov roj cholesterol ntawm cov hlab ntsha.

Sab sij huam

Feem ntau (> 1/100 txog ˂1 / 10)

- mob hauv lub larynx thiab pharynx, ntswg

- flatulence, dyspepsia, xeev siab, raws plab, cem quav

- myalgia, mob caj dab, mob hauv nqua, mob leeg nqaij, mob pob qij txha, mob nraub qaum

- kev hloov pauv ntawm qhov ntsuas ntawm daim siab kev ua haujlwm, kev nce qib ntawm creatine phosphokinase (CPK) hauv cov ntshav (ib theem ntawm kev nce hauv creatine phosphokinase ntau dua 3 zaug siab dua qhov siab tshaj ntawm qhov tsis pub tshaj ntawm cov cai) tau pom nyob rau hauv 2.5% ntawm cov neeg mob noj atorvastatin thiab 10 zaug siab dua cov kev txwv sab sauv ntawm cov cai 0.4% ntawm cov neeg mob)

Qee lub sij hawm (> 1/1000 txog ˂1 / 100)

- npau suav phem, insomnia

- kiv taub hau, mob duav, mob ntshav qab zib, mob ntshav qab zib

- ntuav, mob plab, duav

- caj dab mob, mob leeg tsis muaj zog

- urticaria, tawv nqaij sawv pob, khaus, alopecia

- malaise, asthenia, mob hauv siab, peripheral edema, nkees, ua npaws

- qhov txiaj ntsig zoo rau qhov muaj cov qe ntshav dawb hauv zis

- nce theem ntawm transaminases. Hloov pauv me me, hla thiab tsis tas yuav cuam tshuam kev kho mob. Clinically tseem ceeb (3 lub sijhawm siab dua qhov kev txwv sab sauv ntawm qhov ib txwm) nce siab hauv cov ntshav transaminases tau pom nyob hauv 0.8% ntawm cov neeg mob tau txais atorvastatin. Qhov nce yog koob tshuaj thiab thim rov qab rau hauv txhua tus neeg mob.

Tsis tshua muaj tshwm sim (> 1/10000 txog ˂1 / 1000)

- Quincke's edema, mob ua paug rau tawv nqaij, tawv nqaij daj tawv nqaij daj Stevens-Johnson syndrome, mob ua paug rau cov leeg hlwb, mob erythema multiforme

- myopathy, myositis, rhabdomyolysis, tendinopathy, leeg pob txha caj dab

- nce hauv lub cev hnyav

Tsis tshua muaj heev (> 1/10000 txog ˂1 / 1000)

- hnov qab tsis nco, cim xeeb ploj, amnesia, tsis meej pem

Cov kev mob tshwm sim hauv qab no tau qhia, qhov zaus uas tsis tau tsim

- Mob ntsws interstitial (nrog rau kev kho mob ntev)

- mob ntshav qab zib mellitus, ntau zaus nyob ntawm qhov muaj lossis tsis muaj kev phom sij txog kev pheej hmoo (ceev cov ntshav qabzib> 5.6 mmol / l, BMI> 30 kg / m2, nce triglycerides, keeb kwm ntawm kev kub siab)

- Immuno-mediated necrotizing myopathy

Cov tshuaj sib cuam tshuam

Cov nyhuv ntawm cov tshuaj ntawm atorvastatin

Atorvastatin yog metabolized nrog kev koom tes ntawm cytochrome P450 3A4 (CYP3A4) thiab yog cov txheej txheem rau cov thauj cov protein, piv txwv li, hepatic absorption transporter OATP1B1. Kev siv cov tshuaj ib txhij uas yog CYP3A4 inhibitors lossis thauj cov protein tuaj yeem nce plasma ntau ntau ntawm atorvastatin thiab ua rau muaj kev pheej hmoo ntawm myopathy. Txoj kev pheej hmoo tseem tuaj yeem nce nrog kev siv atorvastatin nrog rau lwm cov tshuaj uas tuaj yeem ua rau mob myopathy, piv txwv li, derivatives ntawm fibroic acid thiab ezetimibe.

Muaj Zog CYP 3A4 inhibitors paub kom ua rau muaj kev nce siab ntxiv hauv atorvastatin concentration. Thaum twg ua tau, siv ib txhij nrog hwj chim CYP 3A4 inhibitors (piv txwv li, nrog cyclosporine, telithromycin, clarithromycin, delavirdine, styripentol, ketoconazole, voriconazole, itraconazole, posaconazole thiab tsawg kawg HIV tiv thaiv inhibitors, suav nrog ritonavir, indarvinavirin lav, thiab lwm tus). Yog tias nws tsis tuaj yeem zam kom tsis txhob muaj kev siv ntau yam tshuaj nrog atorvastatin, koj yuav tsum xav txog kev noj tshuaj atorvastatin nyob rau qhov qis tshaj plaws, thiab kev kuaj mob kom tsim nyog ntawm tus neeg mob tseem pom zoo.

Cov CYP 3A4 inhibitors hauv nruab nrab (piv txwv li, erythromycin, diltiazem, verapamil thiab fluconazole) tuaj yeem nce plasma ntau ntau ntawm atorvastatin. Kev siv txig ib txhij ntawm erythromycin thiab statins yog nrog kev txaus ntshai ntawm myopathy. Cov kev tshawb nrhiav ntawm kev sib cuam tshuam tshuaj tau los tshuaj xyuas cov kev cuam tshuam ntawm amiodarone lossis verapamil ntawm atorvastatin tsis tau ua. Nws paub tias amiodarone thiab verapamil inhibit kev ua si ntawm CYP 3A4, thiab yog li ntawd, tib lub sijhawm tswj hwm ntawm cov tshuaj no nrog atorvastatin tuaj yeem ua rau muaj kev cuam tshuam ntau dua ntawm atorvastatin. Yog li, nrog kev siv atorvastatin thiab siv CYP 3A4 inhibitors ib txhij, muaj peev xwm txo qis tshaj plaws ntawm atorvastatin yuav tsum raug txiav txim siab, thiab kev tshuaj xyuas cov neeg mob kuj pom zoo. Tom qab pib kho nrog ib tus mob inhibitor lossis tom qab kho nws cov koob tshuaj, kev tshuaj xyuas kab mob tsim nyog raug pom zoo.

Cov kua txiv ua kua txiv hmab txiv ntoo muaj ib lossis ntau feem cuam uas txwv tsis pub cytochrome CYP 3A4 thiab tuaj yeem nce plasma ntau dua ntawm atorvstatin, tshwj xeeb tshaj yog noj txiv kab ntxwv qaub ntau dhau (> 1,2 liv ib hnub).

Inductors CYP 3A4

Tib lub sijhawm tswj hwm ntawm atorvastatin nrog cytochrome P450 3A4 inducers (piv txwv li, nrog efavirenz, rifampicin, St. John lub wort) tuaj yeem pab txhawb kom cov ntshav tsis ruaj khov ntawm atorvastatin. Vim tias lub tshuab ua haujlwm ntawm kev sib txuam ob npaug ntawm rifampicin (kev txhawb nqa cytochrome P450 3A thiab kev txwv tsis pub cov kab mob hepatic transporter OATP1B1), kev tswj hwm tib lub sijhawm ntawm atorvastatin thiab rifampicin pom zoo, txij li kev noj atorvastatin nyob rau ib lub sijhawm ntev tom qab rifampicin cuam tshuam nrog kev txo qis ntshav ntau ntawm atorvast. Txawm li cas los xij, cov txiaj ntsig ntawm rifampicin rau kev ua haujlwm ntawm atorvastatin hauv lub siab ua haujlwm hauv lub siab tsis paub, thiab yog tias nws tsis tuaj yeem zam kom tsis txhob siv ib txhij, tus neeg mob cov hauj lwm yuav tsum ua tib zoo saib xyuas.

Cov Tshuaj Txwv Tsis Pub Tshuaj Protein

Cov neeg tiv thaiv ntawm thauj cov protein (piv txwv, cyclosporine) muaj peev xwm txhim kho cov kev cuam tshuam ntawm cov kab ke ntawm atorvastatin. Cov nyhuv ntawm kev tsuj ntawm hepatic ntes vectors ntawm qhov kev txiav txim ntawm atorvastatin hauv daim siab mob hlwb tsis paub. Yog tias nws tsis tuaj yeem zam qhov kev coj ua ib txhij ntawm cov tshuaj no, nws raug nquahu kom txo cov koob tshuaj thiab kev soj ntsuam kev soj ntsuam ntawm cov hauj lwm zoo.

Gemfibrozil / Fiber Acid Derivatives / Ezetimibe

Kev siv cov fibrates thiab ezetimibe raws li kev kho mob monotherapy yog txuam nrog kev nthuav tawm ntawm qhov tshwm sim los ntawm cov leeg, nrog rau rhabdomyolysis. Nrog tib lub sijhawm siv ezetimibe lossis derivatives ntawm fibric acid nrog atorvastatin, txoj kev pheej hmoo ntawm kev tsim cov xwm txheej no yuav nce ntxiv. Yog tias nws tsis tuaj yeem zam kom tau txais kev tswj hwm ua ke ntawm cov tshuaj no, nws yuav tsum siv tshuaj atorvastatin tsawg kawg kom ua tiav lub hom phiaj kho, thiab tshuaj xyuas cov neeg mob kom tsim nyog.

Qhov kev nkag siab ntawm atorvastatin thiab nws cov metabolites hauv cov ntshav ntshav tau qis dua (kwv yees li 25%) thaum noj atorvastatin nrog colestipol. Nyob rau tib lub sijhawm, lipidemic effect ntawm kev sib txuam ntawm cov tshuaj actorvastatin thiab colestipol ntau dhau cov nyhuv uas muab txhua cov tshuaj cais.

Kev tshawb nrhiav ntawm kev sib cuam tshuam ntawm atorvastatin thiab fusidic acid tsis tau ua. Muaj cov ntawv ceeb toom muaj kev phiv los ntawm cov leeg, nrog rau rhabdomyolysis, thaum noj atorvastatin thiab fusidic acid. Tus txheej txheem ntawm kev sib cuam tshuam no tsis paub. Atorvastatin yuav tsum tsis txhob siv nrog fusidic acid. Yog tias nws yuav tsum siv cov kab mob fusidic acid, kev kho nrog statins yuav tsum tsis ua rau tag nrho lub sijhawm ntawm kev kho nrog fusidic acid. Cov neeg mob yuav tsum tau sab laj nrog tus kws kho mob tam sim ntawd yog tias lawv muaj cov tsos mob ntawm cov leeg tsis muaj zog, mob, lossis mob.

Kev kho mob Statin tuaj yeem pib rov qab xya hnub tom qab txhaj koob tshuaj fusidic acid kawg. Muaj qee kis, thaum lub sijhawm ua haujlwm ntev ntawm kev tswj fusidic acid, piv txwv li, rau kev kho mob ntawm kev mob hnyav, kev xav tau sib koom tes tswj hwm ntawm atorvastatin thiab fusidic acid yuav tsum xav txog tus kheej thiab kev kho yuav tsum tau ua nyob rau hauv kev saib xyuas mob nkeeg.

Txawm hais tias tsis muaj kev tshawb nrhiav tau los ntawm kev cuam tshuam ntawm atorvastatin nrog colchicine, cov mob ntawm myopathy tau tshaj tawm nrog kev siv cov tshuaj atorvastatin thiab colchicine, thiab atorvastatin nrog colchicine yuav tsum tau siv nrog ceev faj.

Cov nyhuv ntawm atorvastatin ntawm cov tib neeg siv yeeb tshuaj

Nrog rau kev siv ntau yam ntawm 10 mg ntawm digoxin thiab atorvastatin hauv ntau qhov tshuaj, cov tshuaj kom sib npaug ntawm digoxin nce me ntsis. Cov neeg mob noj digoxin xav tau kev soj ntsuam uas tsim nyog.

Kev siv tib txhij ntawm atorvastatin nrog tshuaj tiv thaiv qhov ncauj pab txhawb kom muaj zog ntau ntxiv ntawm norethindrone thiab ethinyl estradiol.

Cov nyhuv no yuav tsum tau txiav txim siab thaum xaiv qhov ncauj tawm tsam hauv tus poj niam noj atorvastatin.

Txawm hais tias tsuas yog qee qhov mob tsawg kawg ntawm kev kho mob tseem ceeb nrog cov tshuaj tiv thaiv anticoagulants tau tshaj tawm, hauv cov neeg mob noj coumarin anticoagulants, lub sijhawm prothrombin yuav tsum txiav txim siab ua ntej pib kho nrog atorvastatin thiab feem ntau txaus nyob rau theem pib ntawm kev kho kom paub tseeb tias tsis muaj kev hloov pauv tseem ceeb hauv lub sijhawm prothrombin. Thaum lub sijhawm ruaj khov prothrombin lub sijhawm tau sau tseg, nws tuaj yeem soj ntsuam thaum lub sijhawm ib txwm muaj kev pom zoo rau cov neeg mob tau txais cov tshuaj coumarin anticoagulants. Cov txheej txheem qub yuav tsum tau rov ua dua thaum hloov cov tshuaj atorvastatin lossis nws tshem tawm txoj haujlwm. Txoj kev kho Atorvastatin tsis yog nrog los ntawm kis los ntshav lossis hloov lub sijhawm prothrombin hauv cov neeg mob tsis noj tshuaj anticoagulants.

Antacids muaj cov tshuaj magnesium lossis aluminium hydroxide

Nrog rau kev siv txuas ua ke ntawm cov tshuaj tiv thaiv kab mob uas muaj cov tshuaj magnesium lossis aluminium hydroxide nrog atorvastatin, cov tshuaj ntawm cov tom kawg hauv cov ntshav ntshav tsawg dua.

Cov lus qhia tshwj xeeb

Skeletal leeg ua

Atorvastatin, zoo li lwm yam HMG-CoA reductase inhibitors (hydroxymethylglutaryl coenzyme A reductase), qee zaum muaj peev xwm cuam tshuam rau cov leeg nqaij pob txha thiab ua rau mob myalgia, myositis, thiab myopathy, uas tuaj yeem hloov mus rau rhabdomyolysis, lub neej muaj kev phom sij ua rau muaj qhov nce ntawm cov creatine kinase. (QC) (> 10 lub sij hawm VPN), myoglobinemia thiab myoglobinuria, uas tuaj yeem ua rau lub raum tsis ua haujlwm. Tus neeg mob cov keeb kwm ntawm lub raum khiav tsis zoo kuj tseem tuaj yeem ua tus pheej hmoo txaus rau rhabdomyolysis. Nrog kev siv tshuaj atorvastatin nrog rau ntau cov tshuaj, xws li cyclosporine thiab hwj chim CYP 3A4 inhibitors (clarithromycin, intraconazole, HIV protease inhibitors), qhov kev pheej hmoo ntawm kev tsim myopathy / rhabdomyolysis yog nce ntxiv.

Muab Atorvastatin-Teva ib lipid tej koob tshuaj nyob rau hauv ua ke nrog nrog ib tug fibric acid derivatives, erythromycin, cyclosporin, Teli-tromitsinom, immunosuppressants, ob peb ua ke ntawm tus kab mob HIV protease inhibitors (saquinavir, ritonavir, lopinavir nrog ritonavir, tipranavir, ritonavir, darunavir nrog ritonavir, fosamprenavir nrog ritonavir) , nrog niacin, aerosol antifungal tshuaj los yog nicotinic acid, nrog rau colchicine, tus kws kho mob yuav tsum ua tib zoo ntsuas cov txiaj ntsig thiab qhov txaus ntshai ntawm txoj kev kho no thiab saib xyuas qhov mob tas li s mus ntes mob los yog tsis muaj zog nyob rau hauv cov nqaij, tshwj xeeb tshaj yog thaum lub sij hawm thawj ob peb lub hlis ntawm kev kho mob thiab thaum lub sij hawm lub sij hawm ntawm ua koob ntawm tej formulation nyob rau hauv kev twb kev txuas nrog cov kev pheej hmoo ntawm myopathy. Thaum ua ke nrog cov tshuaj saum toj no, txoj hauv kev yuav siv qis dua ntawm kev pib thiab kev saib xyuas cov koob tshuaj atorvastatin yuav tsum raug xam tias yog. Nyob rau tej qhov xwm txheej zoo li no, kev txiav txim siab ntawm CPK cov haujlwm txhua lub sijhawm tuaj yeem pom zoo, txawm hais tias kev saib xyuas zoo li no tsis tiv thaiv kev txhim kho kev mob myopathy.

Cov lus pom zoo rau kev teem caij sib txuam nrog cov tshuaj yog qhia txog cov lus hauv qab no.

Kev sib cuam tshuam txog tshuaj-yeeb tshuaj cuam tshuam nrog kev pheej hmoo ntawm myopathy / rhabdomyolysis

Lub Hom Phiaj

Cyclosporin, HIV protease inhibitors (tipranavir nrog ritonavir), kab mob siab C tus kab mob protease inhibitor (telaprevir), fusidic acid

Zam txhob siv atorvastatin

HIV protease inhibitor (lopinavir nrog ritonavir)

Siv nrog ceev faj thiab koob tshuaj qis kawg qhov xav tau.

Clarithromycin, intraconazole, HIV protease inhibitors (saquinavir nrog ritonavir *, darunavir nrog ritonavir, fosamprenavir, fosamprenavir nrog ritonavir)

Tsis txhob ntau tshaj li ib koob ntawm atorvastatin

HIV tiv thaiv kab mob ntshav siab (nelfinavir), kab mob siab C tus kab mob protease inhibitor (boceprevir)

Tsis txhob noj ntau dua qhov koob tshuaj atorvastatin 40 mg ib hnub twg

* Siv nrog ceev faj thiab ntawm qhov koob tshuaj qis kawg uas xav tau.

Atorvastatin-Teva tau ceeb toom nrog ceev faj rau cov neeg mob uas muaj feem ua rau mob rhabdomyolysis nrog kev txhim kho cov mob raum tsis ua haujlwm vim muaj cov ntshav qog nqaij hlav hauv lub cev thiab myoglobinemia (hypothyroidism, kev mob rau cov leeg mob mus rau hauv lub cev, kev mob raum tsis ua haujlwm, keeb kwm ntawm lub siab mob ntshav qab zib, kev siv tshuaj ntau dhau ntawm kev haus cawv, kev noj cov leeg. keeb kwm ntawm statins lossis fibrates, tus neeg mob laus dua 70 xyoo). Hauv qhov no, nws yog qhov yuav tsum tau kawm txog qib ntawm creatine phosphokinase (KFK), thiab yog tias KFK qib siab dhau 5 zaug, kev kho yuav tsum tsis txhob pib. Thaum kho, yog tias muaj kev yws yws ntawm cov leeg mob, mob plab, tsis muaj zog, kub siab, thiab kub taub hau, nws yog qhov tsim nyog los txiav txim siab txog qib ntawm CPK, thiab yog tias CPK tau siab tshaj 5 zaug, ib ntus lossis tag nres kev kho mob nrog atorvastatin.

Cov neeg mob uas tau noj tshuaj Atorvastatin-Teva yuav tsum ceeb toom tias lawv yuav tsum tau sab laj nrog kws kho mob yog tias tsis hnov mob lossis nqaij tsis muaj zog tshwm sim, tshwj xeeb tshaj yog tias lawv nrog malaise lossis kub taub hau.

Ua rau daim siab

Tom qab kho nrog atorvastatin, qhov tseem ceeb (ntau dua 3 zaug hauv qhov sib piv nrog cov kev txwv sab sauv) qhov kev nce qib hauv ntshav dej ntawm "mob siab" transaminases tau sau tseg.

Nws yog ib qho tsim nyog yuav tau soj ntsuam cov ntsuas ntawm daim siab ua haujlwm thaum lub sijhawm tag nrho ntawm kev kho mob, tshwj xeeb tshaj yog nrog cov tsos ntawm kev kho mob cov tsos mob ntawm daim siab. Nyob rau hauv cov ntaub ntawv ntawm kev nce hauv cov ntsiab lus ntawm hepatic transaminases, lawv cov kev ua haujlwm yuav tsum tau saib xyuas kom txog thaum cov kev txwv ntawm kev suav tau mus txog. Yog tias nce hauv AST lossis ALT kev ua haujlwm los ntawm ntau dua 3 zaug piv nrog kev ntsuas siab ntawm tus neeg ua haujlwm siab, nws raug nquahu tias cov koob tshuaj yuav raug txo lossis tshem tawm.

Cov neeg mob uas siv Atorvastatin-Teva yuav tsum tsis txhob haus cawv. Siv nrog ceev faj hauv cov neeg mob uas quav cawv thiab / lossis raug mob los ntawm daim siab mob (keeb kwm).

Kev Tiv Thaiv Mob Hlav Txo Los ntawm Kev Txo Cov Rog Rog Rog Txo (SPARCL) / Hemorrhagic Stroke

Hauv cov neeg mob uas muaj keeb kwm hemorrhagic mob stroke lossis lacunar infarction, qhov sib npaug ntawm qhov txaus ntshai / cov txiaj ntsig piv ntawm atorvastatin ntawm koob tshuaj 80 mg tsis tau txiav txim siab, thiab yog li ntawd, kev siv Atorvastatin-Teva hauv cov neeg mob no yog ua tau tsuas yog tom qab txiav txim qhov muaj feem / cov txiaj ntsig piv, xav txog qhov pheej hmoo uas yuav rov muaj mob ntshav qab zib.

Kev Siv Tshuaj Tiv Thaiv (Immuno-mediated Necrotic Myopathy) (IONM)

Feem ntau tsis tshua muaj, thaum lub sijhawm lossis tom qab kho nrog qee yam statins, txhaj tshuaj tiv thaiv kab mob immuno-mediated necrotic myopathy (IONM) tau tshaj tawm. IONM raug kuaj pom los ntawm kev ua kom tsis txhob sib zog ua rau cov leeg tsis muaj zog thiab ua kom cov ntshav muaj zog ntau ntau, uas ua rau mob siab txawm tias tom qab kho nrog statins lawm. Nyob rau hauv kis thaum kho nrog atorvastatin yuav tsum tau kho mob tib si nrog cov tshuaj no, nws yuav tsum ua tib zoo kawm kev pheej hmoo / cov txiaj ntsig ntawm kev kho mob ua ke.

Cov mob ntsws interstitial

Muaj qee tus mob ntawm mob ntsws interstitial mob ntsws tau tshaj tawm nrog qee yam statins, tshwj xeeb tshaj yog nyob rau hauv kev kho mob mus ntev. Yog tias thaum lub sijhawm kho mob nws muaj cov tsos mob ntawm kev tshwm sim ntawm kev mob ntsws (ua tsis taus pa, tsis hnoos heev, qaug zog, poob phaus, kub cev), txoj kev kho mob statin yuav tsum tsis ua mus ntxiv.

Statins nce ntshav qab zib, thiab nyob rau qee tus neeg mob uas muaj qhov pheej hmoo loj hauv kev mob ntshav qab zib yav tom ntej, tuaj yeem ua rau mob hyperglycemia, ntawm qhov nws raug nquahu kom pib kho mob ntshav qab zib. Txawm li cas los xij, qhov kev pheej hmoo no tau dhau los ntawm cov txiaj ntsig ntawm kev txo qis kev pheej hmoo rau cov hlab ntshav nrog statins, thiab yog li ntawd yuav tsum tsis txhob yog lub laj thawj ntawm kev txiav cov kev kho statin. Cov neeg mob uas muaj kev pheej hmoo (yoo qab zib ntawm 5.6-6.9 mmol / L, BMI> 30 kg / m2, nce triglycerides, kub siab) noj cov tshuaj statins yuav tsum yog nyob hauv kev soj ntsuam thiab biochemical.

Kev siv ua ke ntawm atorvastatin thiab fusidic acid tsis pom zoo, yog li ntawd, nws yog qhov yuav tsum tau xav txog qhov muaj peev xwm tsis cuam tshuam ib ntus ntawm atorvastatin thaum kho nrog fusidic acid.

Nws yuav tsum tau yug los rau hauv lub siab tias thaum noj Atorvastatin-Teva nrog kua txiv kab ntxwv, cov tshuaj atorvastatin hauv cov ntshav nce ntxiv thiab txoj kev pheej hmoo ntawm kev phiv tawm tuaj.

Kev siv kho cov menyuam yaus

Hauv cov menyuam yaus hnub nyoog qis dua 18 xyoo, qhov ua tau zoo thiab kev nyab xeeb tsis tau teeb tsa vim qhov kev paub dhau los hauv kev siv.

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tsheb lossis cov phom sij phom sij

Muab cov kev phiv los ntawm cov tshuaj, ceev faj yuav tsum tau siv thaum tsav tsheb thiab lwm yam uas yuav muaj kev phom sij.

Daim ntawv tso tawm thiab ntim khoom

10 ntsiav tshuaj nyob rau hauv cov hlwv pob Alu / Alu, muaj cov zaj duab xis ntawm polyvinyl chloride lossis polyvinylidene chloride thiab cov kua roj vanish thiab cov ntawv ci ntawm cov polyvinyl chloride polyamide thiab txhuas ntawv ci.

3 contour ntim pob nrog rau cov lus qhia rau kev siv kho mob hauv lub xeev thiab lus Lavxias tau muab tso rau hauv pob ntawv los qhia.

Atorvastatin-Teva tshuaj: cov lus qhia, contraindications, analogues

Atorvastatin-Teva yog qhov tshuaj hypolipidemic. Tus txheej txheem ntawm kev ua ntawm lipid-txo cov tshuaj yog los txo cov qib "roj" phem, nrog rau cov nyiaj triglycerides thiab lipoproteins ntawm qhov tsawg thiab tsawg tus ceev. Nyeg, lawv nce qhov siab ntawm cov lipoproteins ntau ntom thiab cov roj "zoo".

Atorvastatin-Teva muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab dawb-npog ntsiav tshuaj. Ob daim ntawv sau tau muab sau rau ntawm lawv saum npoo, ib qho yog "93", thiab qhov thib ob nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj. Yog tias qhov koob tshuaj yog 10 mg, tom qab ntawd cov ntawv sau “7310” raug sau, yog tias 20 mg, tom qab ntawd “7311”, yog tias 30 mg, tom qab ntawd “7312”, thiab yog tias 40 mg, ces “7313”.

Lub hauv paus ua haujlwm tseem ceeb ntawm Atorvastatin-Teva yog atorvastatin calcium. Tsis tas li, cov tshuaj muaj pes tsawg leeg suav nrog ntau yam ntxiv, cov tshuaj tiv thaiv kab mob. Cov no suav nrog, piv txwv, lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.

Lub tshuab kev ua ntawm Atorvastatin-Teva

Atorvastatin-Teva, raws li twb tau hais thaum pib, yog tus sawv cev lipid-txo qis. Tag nrho nws lub zog yog tswj kev tiv thaiv, uas yog, inhibiting qhov kev txiav txim ntawm enzyme nyob rau hauv lub npe HMG-CoA reductase.

Lub luag haujlwm tseem ceeb ntawm cov enzyme no yog tswj hwm kev tsim cov roj cholesterol, txij li qhov tsim ntawm nws cov ua ntej, mevalonate, los ntawm 3-hydroxy-3-methyl-glutaryl-coenzyme A. thawj zaug tshwm sim. Cov roj ntsha synthesized, ua ke nrog triglycerides, xa mus rau lub siab, qhov uas nws ua ke nrog lipoproteins tsawg heev. Cov. Cov tshuaj sib txuas tau dhau mus rau hauv cov ntshav ntshav, thiab tom qab ntawd nrog nws tam sim no xa mus rau lwm yam kabmob thiab cov ntaub so ntswg.

Tsawg lipoproteins tsawg kawg yog hloov pauv mus rau qhov tsawg kawg ntawm lipoproteins los ntawm kev hu rau lawv cov receptors tshwj xeeb. Raws li qhov tshwm sim ntawm qhov kev sib txuam no, lawv lub catabolism, i.e., lwj, tshwm sim.

Cov tshuaj txo cov roj cholesterol thiab lipoproteins ntau hauv cov ntshav ntawm cov neeg mob, inhibiting cov nyhuv ntawm qhov enzyme thiab nce tus naj npawb ntawm receptors hauv lub siab rau lipoproteins tsawg ntom. Qhov no ua rau lawv ntes ntau dua thiab pov tseg. Cov txheej txheem ntawm kev coj ua ntawm atherogenic lipoproteins kuj tseem poob qis. Ntxiv rau, cov concentration ntawm cov roj lipoprotein ntau dua cov roj cholesterol nce thiab triglycerides tsawg dua nrog rau apolipoprotein B (cov protein nqa khoom).

Kev siv Atorvstatin-Teva qhia tau muaj txiaj ntsig ntau ntawm kev kho mob tsis yog atherosclerosis, tab sis kuj tseem muaj lwm yam kab mob cuam tshuam nrog lipid metabolism, uas lwm txoj kev kho lipid tsis ua hauj lwm zoo.

Nws tau tsim muaj tias qhov kev pheej hmoo ntawm kev tsim kab mob cuam tshuam nrog kev mob plawv thiab cov hlab ntsha, xws li mob plawv thiab mob hlab ntsha tawg, yog qhov txo qis.

Pharmacokinetics ntawm Atorvastatin-Teva

Cov tshuaj no yog nqus sai heev. Rau li ob teev, qhov siab tshaj plaws ntawm cov tshuaj tau muab teev cia hauv tus neeg mob cov ntshav. Kev nqus, uas yog, kev nqus, tuaj yeem hloov nws txoj kev nrawm.

Piv txwv li, nws tuaj yeem ua rau qeeb dua thaum noj ntsiav tshuaj nrog zaub mov. Tab sis yog tias kev nqus li no poob qis, tom qab ntawd nws tsis cuam tshuam rau cov nyhuv ntawm Atorvastatin nws tus kheej - cov roj (cholesterol) tseem ua rau qis dua raws li kev noj tshuaj. Thaum nkag mus rau hauv lub cev, cov yeeb tshuaj yauv yauv hloov presystemic hloov pauv hauv kev mob plab. Nws yog nruj heev khi rau cov protein ntau - 98%.

Kev pauv hloov pauv tseem ceeb nrog Atorvastatin-Teva tshwm sim hauv lub siab vim raug isoenzymes. Raws li cov txiaj ntsig ntawm cov txiaj ntsig no, cov tshuaj ua kom lub cev yog tsim, uas yog lub luag haujlwm rau kev txwv tsis pub HMG-CoA reductase. 70% ntawm tag nrho cov cuam tshuam ntawm cov tshuaj tshwm sim ncaj qha vim cov metabolites no.

Atorvastatin ua tawm ntawm lub cev nrog cov kab mob hepatic bile. Lub sijhawm thaum lub ntsiab ntawm cov tshuaj nyob rau hauv cov ntshav yuav sib npaug li ib nrab ntawm qhov qub (lub npe hu ua ib nrab neej) yog 14 teev. Qhov ua rau ntawm qhov enzyme yuav kav ntev li ib hnub. Tsis pub ntau tshaj ob feem pua ntawm cov nyiaj uas tau lees txais yuav txiav txim los ntawm kev kuaj tus neeg mob lub tso zis. Rau cov neeg mob uas lub raum tsis ua haujlwm, nws yuav tsum nco ntsoov tias thaum lub sijhawm hemodialysis, Atorvastatin tsis tawm ntawm lub cev mus.

Qhov siab tshaj plaws ntawm kev siv yeeb tshuaj tshaj li qhov kev tswj hwm los ntawm 20% hauv cov poj niam, thiab tus nqi ntawm nws cov kev tshem tawm yog txo 10%.

Hauv cov neeg mob uas muaj mob rau daim siab puas vim yog kev haus cawv tsis txaus, qhov ntau tshaj plaws tau nce txog 16 zaug, thiab cov neeg tso tawm tau nce li 11 zaug, hauv qhov tsis sib thooj.

Kev taw qhia thiab contraindications rau siv

Atorvastatin-Teva yog cov tshuaj siv dav hauv kev kho mob niaj hnub.

Kev kho mob ntawm ib qho ntawm cov kab mob saum toj no thiab cov kab mob pathologies yog coj tawm thaum soj ntsuam cov zaub mov noj uas pab txo cov ntshav muaj roj (muaj cov zaub thiab txiv hmab txiv ntoo, legumes, tshuaj ntsuab, txiv ntseej, nqaij ntses, nqaij qaib, qe), nrog rau thaum tsis muaj txiaj ntsig los ntawm ua ntej thov kev kho mob.

Muaj ib tug xov tooj ntawm cov kev taw qhia nyob rau hauv uas nws ua pov thawj kom zoo heev:

atherosclerosis
thawj hypercholesterolemia,
heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia,
hom xyaw hypercholesterolemia (yam thib ob raws li Fredrickson),
kom triglycerides (plaub yam raws Fredrickson),
tsis txaus ntawm lipoproteins (yam thib peb raws li Fredrickson),
homozygous tsev neeg hypercholesterolemia.

Tseem muaj ob peb qhov kev sib tiv thaiv kom siv ntawm Atorvastatin-Teva:

Cov kab mob mob siab nyob hauv cov theem nquag lossis hauv theem ntawm exacerbation.
Kev nce qib hauv qhov kev kuaj mob hepatic (ALT - alanine aminotransferase, AST - aspartate aminotransferase) ntau dua peb zaug, yam tsis muaj laj thawj,
Daim siab ua haujlwm.
Cev xeeb tub thiab lactation.
Cov menyuam yaus hnub nyoog qis dua.
Kev ua xua tshwm sim thaum noj qee yam ntawm cov tshuaj.

Muaj qee kis, cov tshuaj no yuav tsum tau muab nrog cov kev ceev faj heev. Cov no muaj xws li:

ntau dhau kev haus cawv
mob siab lub siab pathology,
hormonal tsis txaus,
electrolyte tsis txaus,
metabolic ntshawv siab
ntshav siab
cov mob sib kis tau yooj yim
Yog tsis kho mob vwm
kev ua haujlwm loj thiab raug mob,

Tsis tas li ntawd, ceev faj thaum noj cov tshuaj yuav tsum ua kom lub cev muaj nyob rau hauv pathologies ntawm cov leeg ua ke.

Kev cuam tshuam nrog lwm yam tshuaj

Atorvastatin-Teva yog fraught nrog txoj kev txhim kho myopathy - cov leeg tsis muaj zog, zoo li txhua yam tshuaj rau pawg ntawm HMG-CoA reductase inhibitors. Nrog rau kev siv ntau yam tshuaj, kev pheej hmoo ntawm kev txhim kho cov kab mob no tuaj yeem nce ntxiv. Cov no yog cov tshuaj xws li tshuaj tiv thaiv kab mob (ib qho ntawm cov chaw muag tshuaj ntawm cov tshuaj tiv thaiv kab mob), tshuaj tua kab mob (erythromycin thiab macrolides), tshuaj tua kab mob, vitamins (PP, lossis nicotinic acid).

Cov pab pawg no ua rau ib qho enzyme tshwj xeeb hu ua CYP3A4, uas yog lub luag haujlwm tseem ceeb hauv Atorvastatin-Teva metabolism. Nrog hom kev sib txuam no, qib ntawm atorvastatin nyob rau hauv cov ntshav tuaj yeem nce vim yog inhibition ntawm cov azymentioned enzyme, vim tias cov tshuaj tsis tau metabolized zoo. Cov tshuaj raws li cov pab pawg ntawm cov fibrates, piv txwv li, Fenofibrate, inhibit cov txheej txheem ntawm kev hloov pauv ntawm Atorvastatin-Teva, vim qhov txiaj ntsig ntawm nws cov nyiaj hauv cov ntshav kuj nce ntxiv.

Atorvastatin-Teva tseem tuaj yeem ua rau txoj kev txhim kho rhabdomyolysis - qhov no yog ib qho kab mob hnyav uas tshwm sim raws li lub txiaj ntsig ntawm kev ua haujlwm ntev ntawm myopathy. Hauv cov txheej txheem no, cov leeg nqaij ua rau cov kev puas tsuaj loj heev, lawv cov kev faib hauv cov zis yog pom, uas tuaj yeem ua rau mob raum tsis zoo. Rhabdomyolysis feem ntau txhim kho nrog kev siv Atorvastatin-Teva thiab cov pab pawg tshuaj saum toj no.

Yog tias koj sau tshuaj rau hauv qhov siab tshaj plaws uas tau tso cai siv ib hnub (80 mg ib hnub) ua ke nrog mob glycoside Digoxin, tom qab ntawd muaj qhov nce ntxiv ntawm cov tshuaj Digoxin los ntawm kwv yees li ib feem tsib ntawm cov tshuaj noj.

Nws yog qhov tseem ceeb heev los ua ke nrog kev siv ntawm Atorvastatin-Teva nrog kev tswj hwm tshuaj txwv uas muaj cov tshuaj estrogen thiab nws cov keeb kwm, vim tias muaj kev nce qib hauv cov poj niam cov tshuaj hormones. Nws tseem ceeb rau cov poj niam ntawm kev muaj me nyuam hnub nyoog.

Ntawm cov zaub mov, nws tau ua tib zoo txo qis rau kev siv cov kua txiv kab ntxwv qaub, vim nws muaj ntau dua ib qho tshuaj uas txwv tsis pub muaj cov enzyme, nyob rau hauv kev cuam tshuam ntawm cov txheej txheem tseem ceeb ntawm Atorvastatin-Teva coj qhov chaw thiab nws cov qib hauv cov ntshav nce ntxiv. Cov tshuaj no tuaj yeem yuav hauv txhua lub tsev muag tshuaj nrog cov tshuaj noj.

Cov ntaub ntawv hais txog cov tshuaj Atorvastatin tau muab nyob hauv video hauv tsab xov xwm no.