Acetylsalicylic Acid MS

Kev mob rheumatism, mob rheumatoid, mob caj dab-cuam tshuam myocarditis, pericarditis, rheumatic chorea - tsis siv tam sim no.

Kev ua npaws yoov tshaj cum hauv kab mob sib kis thiab mob.

Mob leeg mob (ntawm ntau lub hauv paus pib): mob taub hau (suav nrog cov cuam tshuam nrog kev haus cawv haus cawv), mob taub hau, mob hniav, mob hlwb neuralgia, lumbago, radicular radicular syndrome, myalgia, arthralgia, algodismenorea.

Raws li kev siv tshuaj tiv thaiv kab mob (siv ntau txog 300 mg / hnub): mob plawv, muaj ntau yam kev pheej hmoo rau mob plawv, mob tsis muaj zog myocardial ischemia, tsis nco qab angina pectoris, mob myocardial infarction (los txo cov kev pheej hmoo ntawm myocardial infarction thiab kev tuag tom qab myocardial infarctionia), rov qab ua haujlwm dua yog mob hlwb. mob hlab ntsha hauv cov txiv neej, kev mob plawv hauv lub plawv (kev tiv thaiv thiab kev kho mob ntawm thromboembolism), lub pob txha caj qaum mob angioplasty thiab stent tso (txo txoj kev pheej hmoo ntawm rov mob plab thiab kev kho mob ntawm stratification ntawm txoj hlab ntshav liab), nrog atheros klerotic lesions ntawm cov hlab ntshav (Kawasaki kab mob), aortoarteritis (Kab mob Takayasu), valve mitral lub plawv tsis zoo thiab atrial fibrillation, mitral valve prolapse (tiv thaiv ntawm thromboembolism), mob ntsws, mob ntsws, mob ntsws, mob thiav mob,

Hauv kev txhaj tshuaj tiv thaiv kab mob thiab kev ua xua: ua ntau zuj zus koob tshuaj rau "aspirin" desensitization thiab tsim kev tso siab ruaj khov rau NSAIDs rau cov neeg mob "aspirin" hawb pob thiab "aspirin triad".

Cov Yuav Tsum Muaj

Hypersensitivity, erosive thiab ulcerative lesions ntawm lub plab hnyuv (nyob rau hauv tus mob theem), lub plab zom mov, "aspirin" triad (ua ke ntawm bronchial hawb pob, ua mob polyposis ntawm lub qhov ntswg thiab txhaws kev txhaum thiab tsis txaus siab rau ASA thiab tshuaj ntawm cov pyrazolone series), hemorriliaia diatia (hemorimiliaia) telangiectasias, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura), tshuaj mob pob txha tsis muaj qhov txhab, portal hypertension, vitamin K deficiency, mob raum / raum tsis ua hauj lwm, cev xeeb tub (Kuv thiab III txiav) Stryi), lactation, tsis muaj ntawm glucose-6-phosphate dehydrogenase, cov me nyuam uas muaj hnub nyoog (mus txog 15 xyoo - qhov uas yuav ntawm Reye syndrome nyob rau hauv cov me nyuam nrog hyperthermia rau ib tug tom qab ntawm kab kab mob) .C ceev faj. Hyperuricemia, urate nephrourolithiasis, gout, mob siab, mob plab zom mov thiab / lossis mob duodenal (keeb kwm), decompensated lub plawv tsis ua haujlwm.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Cov ntsiav tshuaj daws: sab hauv, yav tas los yaj nyob rau hauv cov dej tsawg, 400-800 mg 2-3 zaug hauv ib hnub (tsis ntau tshaj 6 g). Hauv mob rheumatism - 100 mg / kg / hnub hauv 5-6 koob.

Cov ntsiav tshuaj uas muaj ASA nyob rau hauv cov koob tshuaj saum toj no 325 mg (400-500 mg) yog tsim los siv ua tshuaj pleev tshuaj tiv thaiv kab mob thiab tiv thaiv kab mob, hauv koob tshuaj ntawm 50-75-100-300-325 mg rau cov laus, feem ntau yog cov tshuaj tiv thaiv kab mob.

Sab hauv, nrog cov tsos mob febrile thiab hnov ​​mob, cov laus - 0.5-1 g / hnub (txog 3 g), muab faib ua 3 koob tshuaj. Lub sijhawm tiv thaiv kev kho mob yuav tsum tsis pub ntau tshaj 2 lub lis piam.

Cov ntsiav tshuaj Effervescent yog yaj hauv 100-200 ml dej thiab noj ntawm qhov ncauj, tom qab noj mov, ib koob tshuaj - 0.25-1 g, noj 3-4 zaug ib hnub. Lub sijhawm kho mob - los ntawm ib koob tshuaj mus rau ntau lub hli chav.

Txhawm rau txhim kho rheological zog ntawm cov ntshav - 0.15-0.25 g / hnub rau ntau lub hlis.

Nrog myocardial infarction, ntxiv rau kev tiv thaiv kab mob thib ob hauv cov neeg mob tom qab myocardial infarction, 40-325 mg ib hnub ib zaug (feem ntau 160 mg). Raws li qhov inhibitor ntawm platelet kev sib sau - 300-325 mg / hnub ntev. Nrog cov kab mob cerebrovascular sib txawv txav hauv cov txiv neej, mob hlwb thomboembolism - 325 mg / hnub nrog maj mam nce mus rau qhov ntau ntawm 1 g / hnub, rau kev tiv thaiv ntawm kev rov huam dua - 125-300 mg / hnub. Rau kev tiv thaiv ntawm thrombosis lossis occlusion ntawm aortic shunt, 325 mg txhua 7 teev los ntawm kev mob plab hnyuv plab, ces 325 mg rau qhov ncauj 3 zaug hauv ib hnub (feem ntau yog ua ke nrog dipyridamole, uas tau muab tshem tawm tom qab ib lub lim tiam, txuas ntxiv kev kho mob ntev nrog ASA).

Nrog kev mob rheumatism tau siv tshuaj (tam sim no tsis yog kws kho mob) hauv koob tshuaj 5-8 g txhua hnub rau cov neeg laus thiab 100-125 mg / kg rau cov hluas (15-18 xyoo), qhov ntau zaus siv yog 4-5 zaug hauv ib hnub. Tom qab 1-2 lub lis piam ntawm kev kho mob, cov menyuam yaus raug txo qhov kev txhaj tshuaj mus rau 60-70 mg / kg / hnub, kev kho mob rau cov neeg laus tau txuas ntxiv hauv tib lub sijhawm, lub sijhawm kho yog txog 6 lub lis piam. Kev tshem tawm yog nqa tawm maj hauv 1-2 asthiv.

Pharmacological kev txiav txim

NSAIDs muaj cov khoom siv los tiv thaiv, ua kom loog thiab antipyretic cuam tshuam nrog kev cais tawm yam tsis muaj kev cuam tshuam ntawm kev ua haujlwm ntawm COX1 thiab COX2, uas tswj kev tsim kho ntawm Pg. Yog li ntawd, Pg tsis yog qhov tsim, muab kev tsim ntawm edema thiab hyperalgesia. Qhov qis dua hauv cov ntsiab lus ntawm Pg (feem ntau E1) nyob rau hauv qhov chaw nruab nrab ntawm cov thermoregulation ua rau muaj qhov txo qis hauv lub cev kub vim tias nthuav tawm cov hlab ntsha ntawm daim tawv nqaij thiab nce tawm hws.

Qhov kev ua kom loog no yog vim ob qho tib si nruab nrab thiab ntu kev ua haujlwm.

Txo cov kev sib sau ua ke, platelet adhesion thiab thrombosis los ntawm inhibiting qhov synthesis ntawm thromboxane A2 hauv platelets. Cov nyhuv antiplatelet tseem mob ntev li 7 hnub tom qab ib koob tshuaj (tshaj tawm hauv tus txiv neej dua li poj niam). Txo cov neeg tuag thiab txoj kev pheej hmoo ntawm kev tsim myocardial infarction nrog tsis khov tsis khov. Nws tau txais txiaj ntsig zoo ntawm kev tiv thaiv thawj hom mob CVD, tshwj xeeb tshaj yog myocardial infarction rau cov txiv neej laus dua 40 xyoo, thiab hauv kev tiv thaiv theem nrab ntawm myocardial infarction.

Hauv kev noj tshuaj txhua txhua hnub ntawm 6 g lossis ntau dua, nws inhibits cov synthesis ntawm prothrombin hauv daim siab thiab nce sijhawm prothrombin ntau ntxiv.

Kev ua ntshav plasma fibrinolytic ntau dua thiab txo qis cov ntsiab lus ntawm vitamin K-dependant coagulation yam (II, VII, IX, X). Nce hemorrhagic muaj kev cuam tshuam thaum lub sij hawm kev phais mob ntxiv, nce qhov kev pheej hmoo los ntshav thaum kho nrog anticoagulants.

Tsim kho txoj kev tsis haum ntawm uric acid (cuam tshuam rau nws txoj kev thim rov qab rau hauv lub raum plab hlaus), tab sis hauv kev siab.

Kev thaiv ntawm COX1 nyob rau hauv lub plab zom mov ua rau lub inhibition ntawm gastroprotective Pg, uas tuaj yeem ua rau ulceration ntawm mucous membrane thiab tom qab los ntshav. Tsawg dua qhov kev cuam tshuam ntawm cov qog ua kua ntawm lub plab zom zaub mov yog cov ntawv tsuas ntau uas muaj cov khoom tsis haum, nkag hauv lub tsho, nrog rau cov ntawv tshwj xeeb "effervescent" ntawm cov ntsiav tshuaj.

Sab sij huam

Xeev siab, tsis qab los noj mov, gastralgia, raws plab, kev tsis haum tshuaj (ua pob ntawm daim tawv nqaij, mob caj dab, mob ntsws), ua rau lub siab thiab / lossis lub raum tsis ua haujlwm, thrombocytopenia, ntshav tsis txaus, leukopenia, Reye syndrome (mob rau daim siab thiab mob siab ua rau lub siab ua rau lub siab ua haujlwm sai) , kev tsim tawm ntawm lub hauv paus ntawm hapten mechanism ntawm "tshuaj aspirin" hawb pob thiab "aspirin triad" (kev sib txuas ntawm tus mob bronchial hawb pob, ua mob polyposis ntawm lub qhov ntswg thiab txhaws qhov ntswg thiab tsis haum rau ASA thiab tshuaj ntawm cov pyrazolone series).

Nrog kev siv ntev - kiv taub hau, mob taub hau, ntuav, mob pob txha thiab mob txhab rau lub plab zom mov, mob hypocoagulation, los ntshav (suav nrog hauv lub plab zom mov), pom kev tsis hnov ​​lus, hnov ​​pob ntseg, tinnitus, bronchospasm, interstitial nephritis, nce prerenal azotemia ntshav creatinine thiab hypercalcemia, papillary necrosis, mob raum tsis ua haujlwm, nephrotic syndrome, aseptic meningitis, cov tsos mob ntawm lub plawv tsis ua haujlwm, edema, nce kev ua haujlwm ntawm "mob ntshav siab" transaminases. Cov tsos mob (ib koob tshuaj tsawg dua 150 mg / kg - raug mob hnyav yog suav tias yog mob sib khuav, 150-300 mg / kg - mob hnyav, ntau dua 300 mg / kg - hnyav): salicylism syndrome (xeev siab, ntuav, tinnitus, plooj tsis pom kev, kiv taub hau, mob hnyav mob taub hau, dav tshwm sim, kub ib ce - ib daim ntawv qhia tus mob tsis zoo hauv cov neeg laus). Kev mob hnyav - hyperventilation ntawm lub ntsws ntawm lub hauv paus hauv paus, ua pa alkalosis, metabolic acidosis, tsis meej pem nco qab, nkees nkees, qaug zog, qaug dab peg, qaug dab peg, los ntshav. Thaum pib, nruab nrab hyperventilation ntawm lub ntsws ua rau ua pa pa ua pa - ua tsis taus pa, ua tsis taus pa, cyanosis, txias, tawm hws, nrog rau intoxication, ua pa tuag tes tuag taw thiab cuam tshuam ntawm oxidative phosphorylation, ua rau ua pa acidosis.

Hauv kev noj tshuaj ntau dhau, lub plasma ntshav tsis zoo ua rau kev cuam tshuam nrog qhov hnyav ntawm intoxication. Qhov teeb meem loj tshaj plaws ntawm kev tsim muaj tus mob mus ntev yog pom nyob rau hauv cov neeg laus uas tau txhaj ntau dua 100 mg / kg / hnub rau ob peb hnub. Hauv cov menyuam yaus thiab cov neeg laus laus, cov tsos mob pib ntawm salicylism tsis yog ib txwm pom, yog li ntawd, nws raug nquahu kom qee lub sijhawm txiav txim siab qhov xav tau ntawm salicylates hauv cov ntshav: qib siab tshaj 70 mg% qhia tau hais tias yog mob hnyav lossis mob hnyav, saum 100 mg% - mob hnyav, kwv yees tsis zoo. Txog rau kev qaug mob me me, yuav tsum tau pw hauv tsev kho mob 24 teev.

Kev Kho Mob: kev npau taws ntuav ntawm lub ntuav, kev teem sij hawm ntawm kev siv lub tshuab hluav ncaig thiab tshuaj pleev ib ce, kev saib xyuas ntawm BOC thiab electrolyte sib npaug, nyob ntawm lub xeev cov metabolism - kev qhia ntawm sodium bicarbonate, sodium citrate lossis sodium lactate. Qhov kev nce ntxiv hauv kev ceev alkalinity ntxiv kho kom zoo rau kev tshem tawm ntawm ASA vim yog alkalization ntawm cov zis. Zis alkalization yog qhia rau salicylates siab tshaj 40 mg% thiab yog muab los ntawm iv infusion ntawm sodium bicarbonate (88 mEq hauv 1 l ntawm 5% dextrose tov, ntawm tus nqi ntawm 10-15 ml / h / kg), kev kho dua ntawm bcc, thiab induction ntawm diuresis tau tiav los ntawm kev qhia ntawm sodium bicarbonate nyob rau hauv tib lub koob tshuaj thiab kev daws teeb meem, uas tau rov ua dua 2-3 zaug. Ceev faj yuav tsum tau tawm dag zog rau cov neeg laus hauv cov neeg mob uas muaj kua ntshav ntxaum ntxiv tuaj yeem ua rau mob ntsws txhaws. Kev siv tshuaj acetazolamide rau kev tso zis ntawm cov zis tsis pom zoo (nws tuaj yeem ua rau mob ntshav qab zib thiab nce cov nyhuv ua rau mob salicylates). Hemodialysis yog qhia rau cov tshuaj salicylates ntau dua 100-130 mg%, hauv cov neeg mob uas muaj tshuaj lom mus ntev - 40 mg% lossis tsawg dua yog tias qhia (kev tiv thaiv kab mob acidosis, muaj kev tsis zoo, muaj kev puas tsuaj ntau rau lub hauv nruab nrab lub paj hlwb, mob ntsws txhaws thiab lub raum tsis ua haujlwm). Nrog pulmonary edema, lub tshuab nqus cua ua kom muaj zog nrog oxygen.

Cov lus qhia tshwj xeeb

Lub sijhawm ntawm kev kho mob (tsis tau sab laj nrog kws kho mob) yuav tsum tsis pub ntau tshaj 7 hnub thaum tshuaj kho mob analgesic thiab ntau dua 3 hnub ua ib qho tshuaj tiv thaiv kab mob.

Tam sim no, kev siv ASA los ua tshuaj tiv thaiv kev tiv thaiv kab mob hauv ib hnub ntawm 5-8 g yog qhov txwv vim qhov muaj feem ntau tshwm sim los ntawm kev mob tshwm sim ntawm txoj hnyuv (NSAID gastropathy).

Ua ntej kev phais mob, txhawm rau txo kev los ntshav thaum phais thiab tom qab lub sijhawm txiav, koj yuav tsum tsum tsis txhob noj salicylates li 5-7 hnub thiab qhia tus kws kho mob.

Thaum lub sij hawm kho cov mob ntev ntev, yuav tau kuaj ntshav feem ntau thiab kuaj ntshav cov ntshav ntawm lub cev.

Cov menyuam yaus yuav tsum tsis txhob raug cov tshuaj noj uas muaj ASA, txij li thaum kis kab mob, lawv tuaj yeem ua rau muaj kev pheej hmoo ntxiv ntawm Tus Mob Reye. Cov tsos mob ntawm Tus Mob Reye cov tsos mob suav nrog mob ntuav ntev, mob encephalopathy, thiab ua rau daim siab.

Teem cov ntsiav tshuaj tom qab noj mov, lawv txoj kev sib tsoo tag nrho, kev siv cov ntsiav tshuaj nrog rau cov yeeb yaj kiab ntxiv lossis txheej nrog rau cov txheej txheem tshwj xeeb, nrog rau kev siv cov tshuaj uas cuam tshuam ib txwm ua rau cov kua qaub ntawm lub plab ua kua, txo cov kev ua rau lub plab zom mov.

Nws muaj cov teebmeem teratogenic, thaum siv thawj peb lub hlis, nws ua rau kev txhim kho ntawm kev txhav ntawm lub sab qaum, hauv peb lub hlis nws ua rau inhibition ntawm kev ua haujlwm (inhibition of Pg synthes), ua ntej kaw ntawm ductus arteriosus hauv tus menyuam hauv plab, mob ntsws ntsig ntshav thiab mob ntshav hauv lub ntsws. Nws yog tawm hauv cov kua mis, uas ua rau muaj kev pheej hmoo los ntshav hauv tus menyuam vim qhov ua haujlwm ntawm cov ntshav plasma tsis zoo.

ASA txawm hais tias nyob rau hauv cov koob tshuaj me me txo qhov kev tsis txaus ntawm uric acid los ntawm lub cev, uas tuaj yeem ua rau kev txhim kho ntawm kev mob hnyav ntawm gout nyob rau hauv cov neeg mob yooj yim.

Thaum lub sijhawm kho mob yuav tsum tsis txhob noj ethanol.

Kev sib txuam

Txhim kho lub tshuaj lom ntawm methotrexate, txo nws lub raum kev ua haujlwm, kev cuam tshuam los ntawm lwm cov NSAIDs, cov tshuaj tiv thaiv kev puas tsuaj, qhov ncauj tshuaj hypoglycemic, reserpine, heparin, indirect anticoagulants, thrombolytics thiab platelet aggregation inhibitors, sulfonamides (suav nrog kev cuam tshuam ntawm co-trimox, txo cov co-trimox) uricosuric tshuaj (benzbromarone, sulfinpyrazone), cov tshuaj tiv thaiv kabmob, diuretics (spironolactone, furosemide).

GCS, ethanol thiab ethanol-muaj cov tshuaj ua rau muaj kev puas tsuaj tshwm sim ntawm lub plab hnyuv, ua rau muaj kev pheej hmoo hauv cov hnyuv ntshav.

Tsub kom cov concentration ntawm digoxin, barbiturates, thiab Li + ntsev rau hauv ntshav.

Cov tshuaj tiv thaiv kab mob muaj Mg2 + thiab / lossis Al3 + qeeb thiab ua rau cov teeb meem tsis haum ntawm ASA.

Myelotoxic tshuaj ntxiv rau qhov tshwm sim ntawm hematotoxicity ntawm cov tshuaj.

Kev siv cov tshuaj acetylsalicylic acid MS thaum cev xeeb tub thiab lactation

Contraindicated nyob rau hauv I thiab III trimesters ntawm cev xeeb tub. Hauv lub sijhawm thib ob ntawm kev xeeb tub, kev nkag mus ib zaug muaj peev xwm ua tau raws li cov cim nruj me ntsis.

Nws muaj cov teebmeem teratogenic: thaum siv thawj peb lub hlis, nws ua rau kev txhim kho ntawm kev txhav ntawm lub sab qaum, hauv peb lub hlis nws ua rau inhibition ntawm kev ua haujlwm (inhibition ntawm prostaglandin synthesis), ua ntej kaw ntawm ductus arteriosus hauv lub plab, mob ntsws ntsig txog ntshav thiab mob ntshav hauv lub ntsws.

Acetylsalicylic acid yog tawm hauv cov kua mis, uas ua rau muaj kev pheej hmoo los ntshav hauv tus menyuam vim los ntawm cov ntshav tsis zoo ua haujlwm, yog li, niam yuav tsum tsis txhob siv tshuaj acetylsalicylic acid thaum lactation.

NSAIDs. Nws muaj kev ua los tiv thaiv, analgesic thiab antipyretic zoo, thiab kuj inhibits platelet tag nrho. Lub tshuab kev ua ntawm kev coj ua cuam tshuam nrog kev cuam tshuam ntawm COX kev ua si - qhov tseem ceeb enzyme ntawm cov metabolism ntawm arachidonic acid, uas yog lub caij nyoog ua ntej ntawm prostaglandins, uas ua lub luag haujlwm tseem ceeb hauv lub pathogenesis ntawm o, mob thiab kub ib ce. Qhov txo qis hauv cov ntsiab lus ntawm prostaglandins (feem ntau E 1) nyob rau hauv qhov chaw ntawm thermoregulation ua rau qhov txo qis hauv lub cev kub vim yog nthuav cov hlab ntsha ntawm daim tawv nqaij thiab nce tawm hws. Qhov kev ua kom loog no yog vim ob qho tib si nruab nrab thiab ntu kev ua haujlwm. Txo txo ​​kev sib sau ua ke, platelet adhesion thiab thrombosis los ntawm inhibiting qhov synthesis ntawm thromboxane A 2 hauv platelets.

Txo cov neeg tuag thiab txoj kev pheej hmoo ntawm kev tsim myocardial infarction nrog tsis khov tsis khov. Ua tau zoo hauv kev tiv thaiv thawj ntawm cov kab mob ntawm cov hlab plawv system thiab hauv kev tiv thaiv kab mob thib ob ntawm myocardial infarction. Hauv kev noj tshuaj txhua txhua hnub ntawm 6 g lossis ntau dua, nws inhibits cov synthesis ntawm prothrombin hauv daim siab thiab nce sijhawm prothrombin ntau ntxiv. Kev ua ntshav plasma fibrinolytic ntau dua thiab txo qis cov ntsiab lus ntawm vitamin K-dependant coagulation yam (II, VII, IX, X). Nce hemorrhagic muaj kev cuam tshuam thaum lub sij hawm kev phais mob ntxiv, nce qhov kev pheej hmoo los ntshav thaum kho nrog anticoagulants. Nws stimulates qhov tsis pom ntawm uric acid (cuam tshuam rau nws txoj kev thim rov qab rau hauv cov hlab ntsha plab hlaws), tab sis hauv koob tshuaj. Kev thaiv ntawm COX-1 hauv lub plab ua rau lub plab ua rau lub plab hnyuv plab prostaglandins, uas tuaj yeem ua rau lub plab zom mov thiab cov ntshav tom qab.

Qee qhov tseeb

Cov tshuaj yog ib txoj kev hais daws uas tshem tawm cov txheej txheem mob.Lub hauv paus tseem ceeb ntawm cov tshuaj yog tshuaj aspirin, uas muaj ntau yam tshwm sim. Lub ntsiab tivthaiv yog cov kua acid zais tawm ntawm willow dawb. Cov tawv ntoo ntawm tsob ntoo nws tus kheej tau siv los ua cov tshuaj hauv tshuaj lom neeg ntau xyoo dhau los. Xyoo 1838, hauv tebchaws Ltalis, tus kws tshuaj Rafael Piria synthesized salicylic acid. Tab sis tsuas yog thaum pib ntawm Lub Yim Hli 1897 hauv Tebchaws Yelemees, tus kws tshaj lij ntawm Bayer AG tau siv cov qauv acetylation rau cov kua qaub, yog li tsim cov kua tshuaj acetylsalicylic acid. Nws lub npe yog Felix Hoffman. Tab sis tseem cov npe lag luam Aspirin koom nrog cov tuam txhab German no.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj hauv cov tshuaj suav nrog cov hauv qab no:

• acetylsalicylic acid
• cov hmoov txhuv nplej siab
• talcum hmoov
• mis nyuj qab zib
• tsis tshua muaj molecular phaus polyvinylpyrrolidone,
• stearic acid.

Cov khoom muaj nyob rau hauv cov ntsiav tshuaj dawb nrog beveled sawv thiab ib qho elliptical. Ntawm ib sab ntawm cov ntsiav tshuaj yog qhov cim cais. Cov tshuaj noj tau ntim rau ob lub hlwv, txhua qhov muaj kaum daim. Cov hlwv nyob hauv cov thawv ntawv thawv nrog cov lus qhia rau siv.

Cov chaw muag tshuaj

Kev siv cov tshuaj acetylsalicylic acid MS yog qhia rau qhov mob, kub taub hau, o. Nws muaj cov txiaj ntsig zoo, vim nws yog COX inhibitor. Cov tshuaj txo cov cev ntau ntxiv, tiv thaiv kev tsim ntawm polyunsaturated fatty acids, uas, nyeg, pab txhawb kev txhim kho ntawm cov mob o. Tsis tas li ntawd, cov tshuaj aspirin ua rau cov hlab ntsha tsis muaj permeable, txo qhov kev ua haujlwm ntawm cov enzymes lub luag haujlwm rau kev tawg ntawm cov kua qaub mucopolysaccharides, thiab maj mam txo cov tsos ntawm ATP.

Cov tshuaj yog nqus kiag li hauv lub cev. Qhov siab tshaj plaws ua tiav tau tiav tom qab 120 feeb. Nws kis tau sai thoob plaws hauv lub cev, nkag mus rau hauv cov pob txha pob txha, cerebrospinal kua, thiab lwm yam Nws tau tawm nrog ua ke nyob rau hauv 60% ntawm qhov tshuaj tau lees. Qhov tsawg kawg nkaus ib nrab-lub neej yog 2 teev, thaum qhov siab tshaj plaws qee zaum ncav cuag 30 teev.

Qhov qhia txog txoj kev noj tshuaj tuaj yeem yog qhov zoo tshaj plaws ntawm cov kab mob, suav nrog:

• kev kho mob ntawm ntau hom mob (taub hau, hniav, leeg thiab pob txha, sib koom tes),
• kev ua txhaum ntawm lub ntsuas kub ntawm lub cev (ARVI, ARI thiab mob o, muaj qhov kis tau zoo),
• malfunctions nyob rau hauv kev ua haujlwm ntawm cov hlab plawv (ischemia, lub plawv nres, lub plawv tsis sib xws, cuam tshuam hauv lub plawv dhia).

Tsis tas li, cov tshuaj tau zoo tuaj yeem daws nrog qhov mob thaum coj khaub ncaws thiab nasopharyngeal cramps.

Txujci thiab kev thov nta

Cov tshuaj aspirin yog tshuaj rau cov neeg laus thiab menyuam yaus hauv kev noj tshuaj hauv qab no:

• los ntawm 6 xyoo, ib nrab ntsiav tshuaj ntawm ib lub sijhawm,
• los ntawm 12 xyoo thiab cov neeg laus ib nrab lossis tag nrho cov ntsiav tshuaj.

Feem ntau siv tshuaj yaj yeeb 3-4 zaug hauv 24 teev, nrog lub sijhawm tsawg kawg 4 teev. Qhov koob tshuaj ntau tshaj plaws rau ib tus neeg laus yuav tsum tsis pub ntau dua 3 gram, uas yog, 6 ntsiav tshuaj, ib qho tshuaj tso cai muaj ntau npaum li cas yog 1 gram. Txhawm rau tshem tawm cov kab mob vascular, nws raug tso cai kom haus ntawm 0.75 txog 3 gram txhua hnub.

Txhua ntsiav tshuaj yuav tsum tau muab ntxuav nrog lub mis lossis dej ntau ntau (muaj ntxhia pob zeb, ua kom distilled). Hauv qhov no, kev siv cov nyiaj yuav tsum tau hais tom qab noj nkaus xwb.

Yog tias cov tshuaj siv los txo qhov kub thiab txias, lub sijhawm siv nws tsis muaj kev tswj hwm los ntawm tus kws kho mob yuav tsum tsis pub dhau peb hnub. Yog hais tias qhov ua rau ntawm kev kho mob yog mob los yog mob, koj tuaj yeem nce lub sijhawm no mus rau ib lis piam.

Kev tiv thaiv kev nyab xeeb

Txhawm rau kom muaj txiaj ntsig ntawm Acetylsalicylic Acid MS, nws yog ib qho tseem ceeb kom ua raws li kev ceev faj:

1. Tsis txhob noj tshuaj aspirin ua ntej lub sijhawm ua haujlwm. Lub cuab yeej tsim tawm los ntshav, vim tias nws yog qhov txaus ntshai siv nws txawm tias ua ntej tshem tawm hniav. Nws yog qhov zoo tshaj rau kev tso mob acid ib lis piam ua ntej kev phais mob.
2. Cov cuab yeej txhim kho qhov gouty ces.
3. Nws raug nquahu kom haus cov tshuaj noj tsuas yog nrog kua pom zoo, vim tias nws txhim kho lawv qhov nqus.
4. Koj tsis tas yuav noj tshuaj rau ntawm lub plab tas, yog li kom tsis txhob tsim kev kub ntxhov.

Thaum cev xeeb tub

Txij li thaum acetylsalicylic acid MS tuaj yeem nkag mus rau hauv thaj chaw placental, nws yog txwv tsis pub siv cov tshuaj no txhua lub sijhawm thaum cev xeeb tub. Cov tshuaj ua rau muaj qhov tsis zoo cuam tshuam rau tus menyuam thiab ua rau lub qeeb, txhaws ntawm cov hlab ntsha thiab cov hlab ntsws, nrog rau kev sib cais ntawm lub sab qaum. Cov tshuaj aspirin yog zais cia hauv cov txheej txheem kev pub mis niam, uas ua rau kom ntshav los ntawm menyuam hauv plab. Yog tias lub cev xeeb tub raug kuaj pom thaum lub sijhawm kho nrog cov tshuaj no, nws yuav tsum tsum tsis txhob noj tam sim ntawd txog thaum kawg pub mis niam.

Sab sij huam

Txawm hais tias muaj kev tiv thaiv ua ntej, cov kev rau txim hauv qab no tuaj yeem tshwm sim vim kev siv cov acetylsalicylic acid MS:

• tsis qab los noj mov, mob plab, kub siab, kiv taub hau, xeev siab, ntuav,
• tinnitus, mob taub hau, tsis pom thiab hnov ​​hnov,
• nce cov teeb meem hauv kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha,
• malfunctioning ntawm ob lub raum lossis mob siab, nephritis,
• o ntawm caj pas thiab qhov ntswg, khaus thiab tawm pob ntawm daim tawv nqaij.

Yog tias koj pom ib lossis ntau yam ntawm cov tsos mob no, koj yuav tsum tau sab laj nrog kws kho mob tam sim ntawd thiab rov qab kho dua tshiab hauv tsev kho mob.

Noj ntau dhau

Raws li txoj cai, kev noj haus ntau tshaj ntawm cov tshuaj aspirin tau faib ua peb ntu, txhua ntu muaj nws cov tsos mob:

1. Nruab Nrab. Ntuav, mob taub hau, kiv taub hau, xav tsis meej. Nws ua kom yooj yim rau tus neeg mob kom txo cov tshuaj noj kom tsawg.
2. Hnyav. Kub taub hau, coma, poob qis hauv lub siab, ua pa ntawm lub cev lossis qhov tsis zoo ua rau thawb huab cua mus rau hauv lub ntsws, kev nce siab ntawm cov piam thaj thiab carbohydrates hauv cov ntshav, acid-puag tseem tshuav nyiaj kuj yuav cuam tshuam.
3. Mob sib kho Nws yog txiav txim los ntawm tus nqi ntawm salicylic acid nyob rau hauv cov ntshav. Yog tias 0.7-1 g ntawm acetylsalicylic acid raug tshawb pom ntawm ib phaus ntawm qhov hnyav, kev ua rau tsev kho mob sai sai tau ua.

Feem ntau, qhib lub tshuab hluav ncaig, hemodialysis, kua dej sib kis, tshem tawm cov tsos mob tiag tiag yog siv rau kev kho mob. Kev ua pa tawm yuav tsum tau muaj.

Cia rau cov neeg mob

Acetylsalicylic acid MS yuav tsum muab cia rau qhov chaw txias thiab qhuav uas qhov kub tsis nce siab tshaj 25 degrees Celsius. Hauv qhov no, cov tshuaj yuav tsum tsis raug rau hluav taws xob ultraviolet, thiab lawv kuj yuav tsum muab zais los ntawm menyuam yaus. Lub txee lub neej ntawm cov ntsiav tshuaj yog 48 hli, pib txij hnub uas qhia ntawm pob. Nws yog txwv tsis pub siv cov khoom tom qab lub sijhawm no.

Ntawm cov tshuaj uas muaj qhov muaj pes tsawg leeg zoo sib xws thiab tib lub ntsiab tseem ceeb yog:

Txawm li cas los xij, cov lus qhia rau kev siv tshuaj tsis tas yuav tsum tau noj tshuaj rau tus kheej, tab sis hais kom meej nrog tus kws kho kom raug qhov tseeb ntawm kev xaiv ntawm cov tshuaj analogue raws li keeb kwm kho mob ntawm ib tug neeg.

Daim ntawv tso cai muab tshuaj LO-77-02-010329 ລົງ hnub Lub Rau Hli 18, 2019

Lub Npe Tsis Muaj Npe International

Cov tshuaj Acetylsalicylic acid (Acetylsalicylic acid).

Acetylsalicylic acid MS (medisorb) yog cov tshuaj nrov tsis-tshuaj steroidal tiv thaiv.

N02BA Salicylic acid thiab nws cov derivatives.

Cov Tshuaj Pharmacokinetics

Kev nqus tau tshwm sim los ntawm txoj hnyuv tag nrho. ASA muab faib rau hauv cov ntaub so ntswg ua qhov tshuaj pleev ib ce ntawm salicylic acid. Cov tshuaj muaj zog tsis tsuas nyob hauv cov ntshav ntshav, tab sis kuj tseem nyob hauv cov leeg pob txha-pob txha mos, thiab hauv cov kua tshuaj synovial (inter-articular).

Kev nqus tau tshwm sim los ntawm txoj hnyuv tag nrho.

Los ntawm lub cev, cov tshuaj tau tawm hauv cov qauv ntawm kev siv tshuaj tiv thaiv kab mob siv txoj kev tso zis. Tus lej zam - los ntawm 2 txog 30 teev, nyob ntawm seb ntau npaum li cas.

Dab tsi pab

ASA muaj qhov kev ua kom dav, tshem tawm cov txheej txheem ua mob thiab txo qhov mob. Ntxiv rau, cov kua qaub acid muaj cov ntshav hauv cov ntshav, uas yog qhov tsim nyog hauv kev kho thiab tiv thaiv cov kab mob plawv. Hauv kev hais txog qhov no, cov tshuaj yeeb yog siv hauv qhov xwm txheej hauv qab no:

• nce lub cev kub thaum lub sijhawm ua mob thiab kis kab mob,
• kev tiv thaiv ntawm cov ntshav txhaws thiab embolism, platelet liquefaction, varicose leeg, thrombosis,
• mob ib qho keeb kwm: mob khaub ncaws, mob to taub, mob taub hau, mob ceeb, thiab lwm yam.
• hauv kev phais kuv siv txoj kev txhaj tshuaj los daws qhov ua npaws thiab mob,
• hlab plawv pathologies: ischemia, arrhythmias, kev tiv thaiv ntawm rov qab myocardial infarction, mob hlab ntsha tawg, Kawasaki kab mob, lub plawv tsis ua haujlwm.

Cov tshuaj yeeb yaj kiab yog siv rau ischemia.
Cov tshuaj yog siv rau varicose leeg.
Cov tshuaj siv rau ntawm qhov kub kom txias.

Ib ntsiav tshuaj tsuas muaj peev xwm raug coj los ua kom qis dua qhov kub lossis txo qis cov mob huam ntse. Hauv cov kab mob ntev ntev, rau kev tiv thaiv lossis kho mob, acetylsalicylic acid yog qaug cawv nrog chav kawm uas tus kws kho mob txiav txim siab nyob ntawm pathology.

Yuav noj cov tshuaj acetylsalicylic acid MS li cas

Cov tshuaj tau noj ua ntej noj mov thiab ntxuav nrog cov ntim ntawm cov dej huv. Nrog ib qho txhaj tshuaj ib zaug, 0.5 mg ntawm cov tshuaj (1 ntsiav tshuaj) yog siv. Siv rov qab siv tau tsis pub dhau 4 teev. Qhov koob tshuaj txhua hnub yuav tsum tsis pub tshaj 6 ntsiav tshuaj.

Hauv kev kho txoj kev mob nyhav los yog mob ntev ntev, ASA raug tshuaj nyob rau hauv ntau npaum li 1 mg tshuaj (2 ntsiav tshuaj) peb zaug ib hnub.

Lub sijhawm kho yog tsis ntau tshaj 7 hnub nrog kev kho mob dav dav thiab tsis pub tshaj 3 nrog rau qhov ntsuas kub tsawg dua. Thaum noj cov tshuaj, nws yog ib qho tseem ceeb kom xyuam xim rau kev noj zaub mov zoo.

Los ntawm cov kab mob zis

Kev tsim kho ntawm lub raum tsis ua haujlwm, tso zis ntau zaus, mob nephrotic, tshwm sim ntawm kev o sai nephritis.

Kev tawm tsam tsis haum tuaj yeem tshwm sim los ntawm kev tsis txaus ntseeg ntawm cov khoom muaj pes tsawg leeg los yog kev siv tshuaj tsis raug cai. Pathology tshwm sim los ntawm tawv nqaij ua pob khaus, khaus. Qee qhov xwm txheej, muaj teeb meem ua pa rau hauv kev sib txuas nrog kev o ntawm lub pharynx.

Txiag tej menyuam

Cov menyuam yaus hnub nyoog qis dua 15 xyoos tsis tau sau cov tshuaj ASA MS vim tias muaj qhov phom sij siab ntawm kev phiv. Qhov tsis suav yog qhov xwm txheej huab cua sov dhau los, uas tus kws kho mob txhaj "triad" (Aspirin, Analgin thiab No-Shpu) intramuscularly rau kev kub ntxhov ceev kom tsawg ntawm qhov kub. Muaj kev xyaum tsis muaj kev pheej hmoo. Hauv qhov txuas ntxiv mus, ASA raug txwv tsis pub siv rau cov menyuam yaus.

Siv thaum cev xeeb tub thiab lactation

Nws tsis pom zoo kom noj cov tshuaj thaum cev xeeb tub, tshwj xeeb tshaj yog thawj peb hlis, thaum tus me nyuam nyuam qhuav sib sau. Hauv lub hlis thib ob, koj tuaj yeem siv cov tshuaj hauv cov koob tshuaj tsawg kawg nkaus, yog tias qhov kev cia siab pom zoo dhau qhov muaj kev pheej hmoo. Vim hais tias cov tshuaj yog nqus mus rau hauv cov ntshav thiab txhua lub hlwb ntawm lub cev, thaum lub sijhawm lactation nws tsis tshua muaj kev pheej hmoo rau noj, yog li kom tsis txhob ua mob rau tus menyuam.

Daim ntawv thov rau lub raum khiav tsis zoo

Thaum lub sijhawm ua haujlwm tsis zoo, ASA tsis siv vim yog qhov tsis muaj ntawm kev tshem tawm cov khoom kawg. Vim tias qhov no, cov metabolism hauv cuam tshuam thiab ua haujlwm ntawm yuav luag txhua yam hauv nruab nrog cev thiab cov tshuab ua kom tsis zoo.

Thaum lub sijhawm ua haujlwm tsis zoo, ASA tsis siv vim yog qhov tsis muaj ntawm kev tshem tawm cov khoom kawg.

Cawv tau zoo

Cov dej cawv muaj cov cawv zom, uas thaum sib cuam tshuam nrog ASA ua rau muaj kev pheej hmoo ntawm lub plab zom mov, kev txhim kho lub plab zom mov lossis mob rau sab hauv thiab kev zom zaub mov tsis zoo.

Ntawm cov tshuaj ntawm ib qho kev ua zoo sib xws, hauv qab no tuaj yeem sau tseg:

• Lub nroog Yeiuxalees
• Aspirin Cardio,
• Cardiomagnyl.

Ntawm cov tshuaj ntawm kev ua zoo sib xws, Cardiomagnyl tuaj yeem sau tseg.
Ntawm cov tshuaj ntawm kev coj ua zoo sib xws, nws tuaj yeem sau tseg
Ntawm cov tshuaj ntawm kev coj ua zoo sib xws, Thrombo Ass.

Nws yog ib qho tseem ceeb kom nco ntsoov tias kev kho mob yam tsis tau sab laj nrog kws kho mob tshwj xeeb tuaj yeem tsim kev phom sij rau kev noj qab haus huv, yog li koj yuav tsum sab laj nrog koj tus kws kho mob ua ntej hloov koj cov tshuaj.

Chaw tsim tshuaj paus

CJSC Medisorb, Russia.

Marina Sergeevna, 48 xyoo, Oryol

Kuv tau noj tshuaj ASA tau ntau xyoo kom yuag cov ntshav. Cardiomagnyl twb tau sau tseg ua ntej lawm, tab sis hauv kev tshawb nrhiav qhov pheej yig analogues, tus kws kho mob tau qhia kuv kom siv cov tshuaj Medisorb. Qhov zoo tshaj plaws tshuaj, Kuv coj nws nruj me ntsis raws li qhov ntau npaum, tsis muaj kev phiv tshuaj.

Ivan Karlovich, 37 xyoo, Yeysk

Txog kev sib koom tes arthrosis, cov tshuaj no tau raug sau tseg. Kuv tsis tuaj yeem hais tias txhua yam nres ua kom mob ncaj, tab sis qhov mob cia ib pliag. ASA pab tsuas yog kho nrog cov kev kho mob nyuaj.