Lub npe kev lag luam rau cov tshuaj insulin glulisin, tus nqi, muaj pes tsawg leeg, cov qauv sib txig sib xyaw, cov tshuab ntawm kev txiav txim, kev taw qhia rau kev siv, contraindications, tshuaj xyuas thiab kev cuam tshuam

Glulin insulin yog ib hom tshuaj ntshav hypoglycemic uas tau siv hauv kev kho mob los kho ntshav tsis haum tshuaj insulin thiab tsis muaj ntshav qab zib. Hauv tsab xov xwm, peb yuav txheeb xyuas cov tshuaj insulin glulisin - lub npe kev lag luam.

Saib xyuas! Hauv kev faib tawm cov tshuaj anatomical-kho-tshuaj (ATX), ib qho tshuaj tau qhia raws li code A10AB06. Lub npe txawv teb chaws tsis npe (Latin lub npe): Khoom noj khoom haus insulin.

Thawj cov qauv ntawm insulin glulisin (C 258H384N64O78S6, M r = 5823 g / mol) yuav luag zoo tib yam rau tib neeg tshwj tsis yog asparagine. Hloov asparagine ntawm txoj haujlwm B3, uas yog tam sim no nyob rau hauv tib neeg cov tshuaj insulin nrog lysine, zoo li lysine ntawm txoj haujlwm B29 nrog glutamic acid, ua rau ntau dua qhov nqus ntawm cov tshuaj mus rau hauv cov ntshav.

Daim ntawv tso tawm

Feem ntau hom tshuaj npe uas nrov tshaj plaws yog Apidra. Sanofi-Aventis Kev ua yeeb yam sai sai tau pom zoo nyob rau lub Cuaj Hli 2004 los ntawm European Commission.

Apidra yog thawj cov tshuaj insulin kom muaj zinc raws li stabilizer (tus choj ntsev ntawm glutamate B29 thiab glycine A1). Cov tshuaj tau los ntawm recombinant DNA technology los ntawm Escherichia coli.

Pharmacodynamics thiab pharmacokinetics

Apidra muaj cov ntshav hypoglycemic thiab antidiabetic. Cov tshuaj muaj qhov pib sai dua thiab lub sijhawm luv dua ntawm kev coj ua nrog kev coj noj coj ua piv nrog cov tshuaj hormones ib txwm muaj. Cov nyhuv tshuaj hypoglycemic ntawm insulin glulisin pib 10-20 feeb tom qab kev tswj hwm thiab kav ntev li 4 teev.

Cov tshuaj insulin yog tsim nyob rau hauv txiav: kab mob beta ntawm cov islets ntawm Langerhans. Thaum lub sij hawm tsim los ntawm cov tshuaj hormone, proinsulin tau muab faib ua cov tshuaj insulin thiab hu ua C-peptide. Yog li ntawd, C peptide tuaj yeem siv los txiav txim siab seb lub cev puas tseem tsim nws cov tshuaj insulin ntxiv.

Hauv cov roj ntsha alpha ntawm tus txiav, lub cev kuj tsim cov tshuaj glucagon. Nws ua yuav luag txhua qhov rov qab ntawm insulin: thaum insulin txo glycemia, glucagon txhawb kev tsim thiab tso cov ntshav qab zib hauv lub siab thiab nce ntxiv.

Cov hnyuv zom zom cov carbohydrates rau hauv monosaccharides. Cov txheej txheem suab thaj no tom qab dhau ntawm lub plab hnyuv phab ntsa rau hauv cov hlab ntshav, thiab tom qab ntawd faib tawm los ntawm muaj rau hauv cov hlwb hauv ntau qhov chaw ntawm lub cev uas lawv tau siv los tsim lub zog.

Cov tshuaj insulin yog ib yam tshuaj uas txhim kho kev nqus ntawm cov piam thaj los ntawm cov cell. Lub hlwb muaj ntau cov kab mob insulin. Yog li, cov piam thaj tuaj yeem nkag ntawm cov hlab ntshav mus rau ntawm qhov chaw tso ntshav. Yog tias lub tshuab no muaj qhov tsis taus, zoo li hom mob ntshav qab zib hom 2, qab zib accumulates hauv cov ntshav.

Qhov tshuaj qog hloov cov piam thaj tsuas yog ua rau lub hlwb ntawm cov leeg, nplooj siab, raum thiab adipose nqaij, tab sis tsis ua rau lub hlwb. Lub hlwb ua haujlwm tuaj yeem noj cov piam thaj tsis muaj tshuaj insulin. Lub cev tseem muaj cov piam thaj, uas tau muab khaws ua glycogen hauv daim siab thiab tshwj xeeb hauv cov leeg.

Ntxiv rau txoj haujlwm tseem ceeb no, qhov tshuaj hormones muaj lwm yam haujlwm hauv lub cev. Cov tshuaj hormone ua rau muaj kev noj qab nyob zoo thiab inhibits qhov tawg ntawm cov ntaub so ntswg adipose (lipolysis). Nrog kev ua tiav ntawm cov tshuaj insulin, thaum tsis muaj piam thaj hauv lub hlwb, lub cev siv cov ntaub so ntswg los tsim lub zog.

Kev taw qhia thiab contraindications

Cov ntshav qab zib uas tsis muaj insulin-thiab muaj ntshav qab zib tsis yog-insulin.

Ib qho tshuaj yog qhov tseeb thaum muaj kev tiv thaiv tsis txaus thiab nrog lub qog ntshav qab zib. Cov ntaub ntawv tag nrho ntawm kev ceev faj thiab kev cuam tshuam tuaj yeem pom nyob hauv cov lus qhia lossis los ntawm koj tus kws kho mob.

Tsuas tshuaj thiab tshaj

Raws li cov lus qhia rau kev siv tshuaj, cov tshuaj yuav tsum tau noj nyob rau hauv 0-15 feeb ua ntej lossis tam sim ntawd tom qab noj mov. Cov tshuaj yog txhaj subcutaneously rau hauv plab phab ntsa, ncej puab lossis sab caj npab sab saud. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw tas li kom tsis txhob muaj kev phiv hauv zej zog. Qhov tshuaj hormones kuj tseem tuaj yeem muab tso dej siab siv ib lub twj tso kua mis thiab lwm yam tshwj xeeb.

Thaum muab tshuaj subcutaneously, kev saib xyuas yuav tsum tau ua kom ntseeg tau tias cov ntsiab lus kho tau zoo ib yam. Hauv txoj ntsiab cai, nws tseem tuaj yeem raug tswj hwm hauv intramuscularly, tab sis hom kev tswj hwm no tsis pom zoo, vim nws tuaj yeem ua rau mob leeg. Peb hom kev tswj hwm muaj qhov sib txawv. Cov ntaub ntawv tshaj tawm hais txog qhov cuam tshuam ntawm cov kua dej yog ib txwm ua raws kev tswj hwm subcutaneous. Kev tswj hwm intramuscular feem ntau ua rau kev nrawm nrawm ntawm qhov pib ntawm cov nyhuv los ntawm 30-50%. Thaum qhia rau hauv thaj chaw ua haujlwm ntawm cov leeg, cov nyhuv yuav tsis tuaj.

Ua ke, insulin yuav tsum tau tswj hwm nkaus xwb nrog kev ceev faj, vim tias qhov pib tshwm sim tam sim ntawd. Cov ntshav qab zib pib kom poob sai. Kev poob sai, nrog rau muaj ntshav qab zib ntau dhau, ua rau lub cell puas. Yog li, cov tshuaj insulin raug tswj hwm tsuas yog thaum muaj xwm txheej ceev thiab txawm tias muaj pes tsawg.

Txhawm rau kom tsis txhob muaj cov calcium-cholesterol tso rau ntawm cov hlab ntsha (tom qab muaj kev cuam tshuam) thaum muaj mob siab ceev, nws tsis pom zoo kom tswj hwm cov tshuaj ntawm txoj leeg. Qhov kom zoo dua ntawm kev tswj hwm ntawm kev ua haujlwm ntawm insulin yog tias cov nyhuv yuav luag ploj mus tom qab 50 feeb.

Txoj kev pheej hmoo ntawm cov ntshav qog nqaij hlav tawm los ntawm qhov ua tau sai ntawm cov tshuaj yuav tsum tiv thaiv los ntawm cov thawj coj ntawm cov piam thaj.

Kev siv tshuaj insulin rau cov tshuaj tuaj yeem nqa nrog cov tshuaj insulin koob txhaj. Qee lub sij hawm tus neeg mob hnov qab nws yog xim hlau tom qab kev siv tshuaj.

Kev sib txuam

Thaum noj cov khoom xyaw hauv qab no, cov nyhuv ntawm cov tshuaj yeeb tshuaj tsub zuj zus:

Monoamine oxidase inhibitors
Beta blockers,
Angiotensin hloov mus rau enzyme inhibitors,
Cov tshuaj tiv thaiv tsis zoo
Cov tshuaj tiv thaiv hypocholesterol
Cov tshuaj rau lub hlwb - fluoxetine, tetrahydrocannabinol, ethanol,
Opioid Kev Ua Phem Rau Ntshav - Morphine,
Penoxifylline
Tshuaj tua kab mob Sulfonamide
Acetylsalicylic acid.

Nws raug nquahu kom nrog koj tus kws kho mob tham txog lwm cov kev sib cuam tshuam. Hypothetically, cov tshuaj tuaj yeem cuam tshuam nrog txhua yam tshuaj uas cuam tshuam rau tus neeg mob glycemia. Yog li, nws yuav tsum tau sab laj nrog tus kws kho mob ua ntej siv cov tshuaj nyob rau hauv kev tiv thaiv kom tsis txhob muaj kev rau txim.

Analogs thiab hloov pauv rau cov tshuaj:

Lub npe tshuaj (hloov)	Yam khoom muaj sia	Kev kho siab tshaj plaws	Nqe ib pob, rub.
Lub sijhawm	Dulaglutide	5-8 teev	1000
Rosinsulin M sib tov	Cov tshuaj insulin	12-24 teev	700

Lub tswv yim ntawm tus kws kho mob thiab tus neeg mob.

Cov tshuaj yog ultrashort kev txiav txim uas haum rau cov neeg mob ntshav qab zib uas raug kev txom nyem los ntawm mob hnyav postprandial hyperglycemia. Ua ntej siv, koj yuav tsum tau kho lub koob tshuaj nrog koj tus kws kho mob kom tsis txhob mob ntshav qab zib.

Mikhail Alexandrovich, kws kho ntshav qab zib

Kuv qhia ua ntej ua tshais. Lawv tsis xav tias muaj qhov tsis zoo, tsuas yog muaj qhov co me me xwb. Raws li glucometer qhia, glycemia tseem nyob ruaj khov tom qab noj tshais hearty. Kuv tseem yuav ua kom paub.

Ultrashort insulin Glulizin - cov yam ntxwv thiab cov yam ntxwv ntawm kev thov

Video (nyem mus ua si).

Ntawm hom ntshav qab zib hom 1, tus neeg mob tuaj yeem siv cov kev siv tshuaj sai (sai), luv luv, nruab nrab, ua kom ntev thiab muaj cov tshuaj tiv thaiv ua ntej.

Qhov twg yog qhov tau sau tshuaj rau kev noj tshuaj kom zoo txaus nyob ntawm tus neeg yam ntxwv ntawm lub cev. Thaum ultra-luv luv insulin xav tau, Glulisin siv.

Insulin Glulisine yog ib qho piv txwv ntawm tib neeg cov kua dej, uas zoo sib xws hauv txoj ntsiab cai rau cov tshuaj no. Tab sis los ntawm xwm, nws ua tau nrawm dua thiab muaj cov qauv luv luv.

Glulisin tau nthuav tawm raws li kev daws teeb meem rau kev tswj hwm ntawm subcutaneous. Nws zoo nkaus li ua kua pob tshab tsis muaj impurities.

Cov npe lag luam rau cov tshuaj uas nws muaj: Apidra, Epidera, Apidra Solostar. Lub hom phiaj tseem ceeb ntawm cov tshuaj yog mus tswj cov metabolism hauv qabzib.

Video (nyem mus ua si).

Raws li kev paub dhau los, qhov zoo thiab tsis zoo hauv qab no tuaj yeem sib txawv:

ua nrawm dua li tib neeg hormone (+),
zoo txaus siab qhov xav tau khoom noj hauv cov kua dej (+),
peev xwm tsis muaj kev cuam tshuam ntawm cov nyhuv ntawm cov tshuaj ntawm cov piam thaj (-),
siab zog - chav tsev txo cov suab thaj ntau dua li lwm cov insulins (+).

Tom qab kev tswj hwm subcutaneous, muaj ib qho txo qis hauv qabzib vim qhov kev txhawb nqa ntawm nws txoj kev siv ntu hauv cov ntaub so ntswg thiab kev tawm tsam ntawm cov txheej txheem no hauv lub siab. Qhov kev txiav txim pib 10 feeb tom qab txhaj tshuaj.

Nrog kev qhia txog Glulisin thiab cov insulin tsis tu ncua ob peb feeb ua ntej noj mov, yav tas los ua kom zoo dua glycemic tswj tom qab noj mov. Lub bioavailability ntawm yam khoom yog li 70%.

Kev sib txuas lus nrog cov protein ntshav yog negligible. Nws yog tawm me ntsis sai dua li niaj zaus kev txhaj tshuaj tib neeg. Ib nrab-lub neej ntawm 13,5 feeb.

Cov tshuaj tau muab rau noj tam sim ntawd ua ntej noj mov (rau 10-15 feeb) lossis tam sim ntawd tom qab noj mov, noj rau hauv cov txheej txheem kev kho mob dav dav nrog lwm cov insulins (los ntawm lub sijhawm ntawm kev nqis tes lossis los ntawm keeb kwm) Txoj kev tswj hwm: subcutaneously hauv tus ncej puab, lub xub pwg. Txhawm rau kom tsis txhob raug mob, qhov chaw txhaj tshuaj yog zaws. Cov tshuaj raug muab tshuaj rau ntau qhov chaw, tab sis nyob hauv tib thaj chaw.

Glulisin koom ua ke nrog cov insulins thiab kab mob hauv qab no:

nrog ib qho analog ntawm basal hormone,
nrog nruab nrab
nrog ntev
nrog rau cov tshuaj hypoglycemic.

Lub zog ntawm glycemia nrog ntxiv ntawm insulin Glulizin rau kev kho nrog basal insulin

Yog tias txoj kev daws teeb meem yog xav siv cov koob txhaj koob txhaj tshuaj, kev txhaj tshuaj yog ua raws li cov lus qhia rau lub tshuab no. Cov ntau npaum ntawm cov tshuaj yog xaiv ib tus zuj zus, suav txog tus neeg mob tus mob thiab theem ntawm kev them nyiaj.

Ua ntej siv Glulizin, refilled hauv daim cartridge, kev tshuaj xyuas yog nqa tawm - cov av nkos nrog kev suav nrog tsis tsim nyog siv.

Video qhia siv kev xaum xim:

Ib yam tshuaj raug xaj nyob rau qee yam hauv qab no:

Cov tshuaj tiv thaiv kom tsis txhob xaiv lub sijhawm tshuaj yog li nram qab no:

ntshav qab zib,
hypersensitivity rau glulisin,
hypersensitivity rau ntu ntu ntawm cov tshuaj.

Hauv chav kawm ntawm kev kho nrog tshuaj, phiv tshuaj tuaj yeem tshwm sim.

Qhov nquag ntawm cov xwm txheej tsis zoo hauv cov lej, qhov twg 4 yog qhov muaj ntau, 3 feem ntau, 2 yog tsawg, 1 tsawg tsawg:

Thaum lub caij noj tshuaj ntau dhau hwv lawm, kev soj ntsuam ntshav lub qog ntshav qis. Nws tuaj yeem tshwm sim yuav luag tam sim ntawd lossis txhim kho maj mam.

Ua raws li kev siv cov tshuaj insulin ntau npaum li cas, lub sijhawm thiab qhov mob hnyav tshaj plaws, tus mob hypoglycemia yuav plooj ntau dua. Tus neeg mob yuav tsum txiav txim siab cov ntaub ntawv no txhawm rau txhawm rau tiv thaiv tus mob kom raws sijhawm. Txhawm rau ua qhov no, koj yuav tsum muaj qab zib (khaub noom, chocolate, ncuav qab zib ntshiab) nrog koj.

Nrog cov ntshav qog ua kom qis thiab ntshav qab zib kom qis, cov khoom qab zib uas muaj suab thaj yog noj. Hauv cov mob hnyav, uas nrog nrog tsis nco qab, yuav tau txhaj tshuaj.

Kev nyem ntawm hypoglycemia tshwm sim nrog kev pab ntawm glucagon (s / c lossis i / m), kua nplaum tov (i / v). Hauv 3 hnub, tus neeg mob raug saib xyuas. Txhawm rau tiv thaiv kev txhim kho ntawm kev rov ua qog ntshav, nws yog ib qho tsim nyog yuav tsum tau noj cov carbohydrates tom qab ib ntus.

Thaum pib ntawm kev kho mob nrog ultrashort insulin, nws txoj kev cuam tshuam nrog lwm cov tshuaj noj tau coj los ua.

Ntau yam tshuaj yuav cuam tshuam rau cov metabolism hauv qabzib, txhim kho lossis txo qis cov teebmeem ntawm kev tsim cov tshuaj insulin. Ua ntej kev kho mob, tus neeg mob yuav tsum tau qhia rau hauv kev tiv thaiv kom tsis txhob muaj qhov ua rau tsis pom zoo.

Cov tshuaj hauv qab no txhim kho cov nyhuv ntawm Glulisin: Fluoxetine, hypoglycemic agents hauv cov ntsiav tshuaj, tshwj xeeb, sulfonylureas, sulfonamides, salicylates, fibrates, ACE inhibitors, Disopyramide, MAO inhibitors, Pentoxifylline, Propoxifen.

Cov tshuaj hauv qab no txo cov nyhuv ntawm kev kho mob insulin: atypical antipsychotics, sympathomimetics, tshuaj tiv thaiv qhov ncauj, cov thyroid hormones, glucagon, poj niam txiv neej cov tshuaj hormones, thiodiphenylamine, somatropin, diuretics, glucocorticosteroid tshuaj (GCS), proteinase inhibitors,

Pentamidine, beta-blockers, thiab clonidine raug xa mus rau cov tshuaj uas tsis muaj kev cia siab tuaj yeem cuam tshuam lub zog ntawm Glulisin raug ntau thiab cov piam thaj (txo qis thiab nce ntxiv). Cawv muaj tib lub zog.

Kev xyuam xim tshwj xeeb yog pom thaum sau ntawv Pioglitazone rau cov neeg mob plawv. Thaum ua ke, cov xwm txheej ntawm kev loj hlob ntawm lub plawv nres tau qhia hauv cov neeg mob uas muaj lub siab xav ua tus mob no.

Yog tias kev kho mob nrog Pioglitazone tsis tuaj yeem raug tshem tawm, nws yog ib qhov tsim nyog los soj ntsuam tus mob. Yog tias ib qho kev mob plawv (qhov hnyav nce, o) tshwm sim, qhov kev siv ntawm cov tshuaj tau raug muab tso tseg.

Tus neeg mob yuav tsum xav txog cov hauv qab no:

Nrog lub raum ua haujlwm lossis ua txhaum hauv lawv txoj haujlwm, xav tau cov tshuaj insulin yuav tsawg dua.
Nrog lub siab ua haujlwm ntawm lub siab, qhov xav tau kuj poob qis.
Vim tias tsis muaj cov ntaub ntawv, cov tshuaj tsis raug txwv rau cov menyuam yaus hnub nyoog qis dua 6 xyoo.
Siv nrog ceev faj nyob rau hauv cov poj niam cev xeeb tub nrog nquag saib xyuas ntawm ntsuas.
Thaum lub sijhawm lactation, koob tshuaj thiab kev noj haus kev kho mob yuav tsum muaj.
Thaum hloov mus rau Glulisin los ntawm lwm qhov tshuaj tiv thaiv vim muaj qhov tsis haum lub cev, kev ntsuas tshuaj tiv thaiv ua xua yuav tsum tau ua kom tsis txhob sib xyaw khaub thuas.

Koob tshuaj hloov kho yog tau ua tiav thaum hloov pauv los ntawm lwm hom kev txhaj tshuaj hormone. Thaum hloov tsheb los ntawm cov tsiaj insulin rau Glulisin, cov koob tshuaj feem ntau kho nyob rau hauv cov kev coj ua kom txo qis tom kawg. Qhov xav tau ntawm cov tshuaj tuaj yeem hloov nrog kev xav ntau dhau / kev tiv thaiv kev xav, thaum lub sijhawm sib kis tus kab mob.

Cov txheej txheem yog tswj hwm nrog kev pab ntawm ntsiav tshuaj hypoglycemic tshuaj. Yog tias koj hloov ib qho twg hauv cov phiaj xwm, koj yuav tau kho qhov tshuaj ntawm Glulisin.

Feem ntau ntawm hyperglycemia / hypoglycemia, cov tshuaj tiv thaiv kab mob hauv qab no yog qhov tau teev ua ntej hloov pauv kev noj tshuaj:

cov txheej txheem thiab qhov chaw siv tshuaj yaj yeeb,
nruj mas ua raws cov txheej txheem kho mob,
kev noj lwm yam tshuaj rau hauv parallel
psycho-txoj kev xav lub xeev.

Txee lub neej tom qab qhib - lub hli

Cia - ntawm t ntawm +2 txog + 8ºC. Tsis khov!

Lub sijhawm so haujlwm yog mus tshuaj.

Glulisin yog qhov piv rau tib neeg cov tshuaj insulin:

Glulisin yog yam tshuaj ultrashort rau kev tswj cov metabolism hauv qabzib. Nws yog tawm hauv kev sib xyaw nrog lwm cov insulins, coj mus rau hauv tus account lub phiaj xwm uas raug xaiv. Ua ntej siv, nws yog ib qho tseem ceeb kom kawm cov lus qhia tshwj xeeb thiab sib cuam tshuam nrog lwm yam tshuaj.

Cov tshuaj insulin glulisin: cov lus qhia rau kev siv

Insulin glulisin yog tshuaj noj rau kev kho mob los ntawm cov ntshav qab zib uas tsis yog insulin los yog tsis-insulin-raws li. Nws yog qhia rau hauv lub cev tsuas yog nrog kev pabcuam ntawm kev txhaj tshuaj. Zoo tswj tau glycemia ntsuas.

Insulin glulisin yog tshuaj rau kev kho mob ntawm insulin-dependant lossis tsis mob ntshav siab insulin-rau cov ntshav qab zib.

ATX encoding - A10AV06.

Muaj nyob hauv cov npe kev lag luam Apidra thiab Apidra SoloStar.

Cov tshuaj yog siv tshuaj yaj yeeb ntawm tib neeg cov tshuaj insulin.Lub zog ntawm kev nqis tes ua zoo ib yam li cov tshuaj hormones uas tsim los ntawm kev noj qab haus huv txiav zoo. Glulisin ua tau nrawm dua thiab muaj lub sijhawm ntev.

Tom qab kev tswj hwm rau lub cev (subcutaneously), qhov tshuaj hormones pib tswj cov metabolism metabolism.

Cov tshuaj txo cov concentration ntawm cov ntshav qab zib, txhawb nws txoj kev nqus los ntawm cov ntaub so ntswg, tshwj xeeb tshaj yog cov nqaij pob txha thiab cov nqaij mos adipose. Nws inhibits qhov tsim los ntawm cov piam thaj hauv cov nqaij hauv lub siab. Tsub kom muaj protein ntau sib txuas.

Cov kev tshawb fawb soj ntsuam pom tias glulisin, siv 2 feeb ua ntej noj mov, muab tib qho kev tswj cov piam thaj hauv ntshav li tib neeg cov tshuaj insulin, muab ib nrab ib teev ua ntej noj mov.

Kev ua haujlwm ntawm insulin tsis hloov pauv ntawm cov neeg sib txawv ntawm ntau haiv neeg.

Tom qab subcutaneous tswj hwm ntawm cov tshuaj, qhov siab tshaj plaws nyob rau hauv cov ntshav tau mus txog tom qab 55 feeb. Qhov nruab nrab lub sijhawm nyob ntawm qhov tshuaj nyob hauv cov hlab ntshav yog 161 feeb. Nrog kev coj ua subcutaneous ntawm cov tshuaj mus rau thaj av ntawm thaj chaw ntawm sab xub ntiag phab ntsa lossis xub pwg, kev nqus sai dua nrog kev qhia ntawm cov tshuaj rau hauv tus ncej puab. Bioavailability yog li ntawm 70%. Qhov kev tshem tawm ib nrab-lub neej yog kwv yees li 18 feeb.

Tom qab kev tswj hwm subcutaneous, glulisin yog tawm sai sai dua li cov tib neeg muaj insulin. Nrog rau lub raum puas, qhov ceev ntawm qhov pib ntawm cov txiaj ntsig xav tau yog tswj. Cov ntaub ntawv hais txog kev hloov pauv ntawm cov teeb meem pharmacological ntawm insulin hauv cov neeg laus tsis tau ua haujlwm txaus.

Glulisin tau qhia rau cov ntshav qab zib xav tau insulin thiab ntshav qab zib hom 2.

Cov tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv ntawm hypoglycemia thiab hypersensitivity rau Apidra.

Nws yog noj subcutaneously 0-15 feeb ua ntej noj mov. Qhov kev txhaj tshuaj yog tsim nyob rau hauv lub plab, ncej puab, xub pwg. Tom qab txhaj tshuaj, koj tuaj yeem tsis zaws thaj chaw txhaj tshuaj. Koj tsis tuaj yeem sib xyaw ntau hom tshuaj insulin nyob rau hauv tib lub koob txhaj, txawm hais tias tus neeg mob yuav tau txais cov tshuaj insulins sib txawv. Kev thim rov qab ntawm cov tshuaj ua ntej nws cov kev tswj hwm tsis pom zoo.

Ua ntej siv, koj yuav tsum kuaj xyuas lub raj mis. Nws yog qhov tsim nyog kom sau cov tshuaj rau hauv cov koob txhaj tshuaj tsuas yog tias qhov kev daws teeb meem yog pob tshab thiab tsis muaj cov khoom tawg.

Tib tus cwj mem yuav tsum tsuas yog siv los ntawm ib tus neeg mob. Yog tias nws raug puas, nws tsis raug tso cai siv nws. Ua ntej siv tus cwj mem, ua tib zoo saib xyuas daim cartridge. Nws tuaj yeem siv nkaus xwb thaum daws tau qhov tseeb thiab tsis muaj kev cuam tshuam. Tus cwj mem khoob yuav tsum tau muab pov tseg raws li tsev neeg pov tseg.

Cov tshuaj tau muab tshuaj subcutaneously 0-15 feeb ua ntej noj mov. Qhov kev txhaj tshuaj yog tsim nyob rau hauv lub plab, ncej puab, xub pwg. Tom qab txhaj tshuaj, koj tuaj yeem tsis zaws thaj chaw txhaj tshuaj.

Tom qab hle lub hau tawm, nws pom zoo kom kuaj xyuas daim paib thiab daws. Tom qab ntawd ua tib zoo muab lub taub hau tso rau hauv cov xias. Hauv cov khoom siv tshiab, ntsuas qhov ntsuas pom tias "8". Hauv lwm cov ntawv thov, nws yuav tsum tau teeb rov qab rau qhov ntsuas "2". Nias lub khawm dispenser txhua txoj kev.

Tuav lub kov kom sawv, tshem tawm cov cua npuas los ntawm npuaj. Yog tias txhua yam ua tiav zoo, qhov poob me me yuav tso tawm ntawm lub taub hau. Cov cuab yeej tso cai rau koj teeb tsa qhov ntau npaum li ntawm 2 txog 40 ib pawg. Qhov no tuaj yeem ua tiav los ntawm kev hloov cov dispenser. Rau kev them nqi, lub khawm dispenser tau pom zoo kom rub txhua txoj kev.

Ntxig lub koob txhaj rau hauv daim ntaub subcutaneous. Tom qab ntawd nias lub pob txhua txoj kev. Ua ntej tshem tawm rab koob, nws yuav tsum tuav li 10 vib nas this. Tom qab txhaj tshuaj, tshem tawm thiab pov tseg cov koob. Cov teev qhia pom ntau npaum li cas kwv yees li ntawm insulin nyob rau hauv cov koob txhaj tshuaj.

Yog tias tus nqus dej tsis ua hauj lwm zoo, tom qab kev daws teeb meem tuaj yeem kos los ntawm daim cartridge mus rau hauv cov phwj.

Feem ntau cov kev mob tshwm sim ntawm cov tshuaj insulin yog cov ntshav qog ntshav qab zib. Nws tuaj yeem tshwm sim vim kev siv cov koob tshuaj ntau ntawm cov tshuaj. Cov tsos mob ntawm kev poob qis hauv cov ntshav qab zib pib maj mam tshwm sim:

hws no
pallor thiab txias ntawm daim tawv nqaij,
mloog zoo li nkees heev
kev zoo siab
pom kev tsis sib to taub
tshee hnyo
zoo kawg li ntxhov siab vim
tsis meej pem, nyuaj mloog,
lub zog hnov mob hauv cov mob taub hau,
palpitations.

Kev muaj ntshav qab zib ntau ntau yuav nce ntxiv. Qhov no yog lub neej hem, vim nws ua rau muaj kev cuam tshuam loj heev ntawm lub hlwb, thiab nyob rau hauv cov mob hnyav - tuag.

Ntawm qhov chaw txhaj tshuaj, nws khaus thiab o tuaj yeem tshwm sim. Xws li kev tawm tsam ntawm lub cev yog hloov dhau mus, thiab koj tsis tas yuav tsum noj tshuaj kom tshem tawm. Tej zaum muaj kev txhim kho lipodystrophy hauv cov poj niam ntawm qhov chaw txhaj tshuaj. Qhov no tshwm sim yog tias nws tau nkag mus rau tib qho chaw. Txhawm rau tiv thaiv qhov no los ntawm tshwm sim, thaj chaw txhaj tshuaj yuav tsum tau sib hloov.

Muaj tsawg kawg uas qhov tshuaj muaj peev xwm ua rau muaj kev tsis haum tshuaj.

Nrog hypoglycemia, nws yog txwv tsis pub tsav tsheb los yog tsav txoj haujlwm nyuaj.

Hloov chaw ntawm tus neeg mob rau ib hom tshuaj insulin tshiab yog ua tiav los ntawm kev saib xyuas mob nkeeg nkaus xwb. Qee qhov xwm txheej, kev kho mob ntshav qab zib tej zaum yuav tsum tau ua. Thaum hloov lub cev kev qoj ib ce, koj yuav tsum kho lub koob tshuaj kom haum.

Cov tshuaj yuav siv tau thaum muaj hnub nyoog laus. Koob tshuaj yuav tsis haum yog li ntawd.

Hom insulin no tuaj yeem kho rau cov menyuam yaus txij thaum muaj hnub nyoog rau xyoo.

Tsuas muaj pov thawj tsawg txog kev siv cov tshuaj no thaum xeeb tub thiab pub niam mis. Kev tshawb nrhiav tsiaj ntawm cov tshuaj tsis tau qhia txog txhua tus neeg hauv lub cev xeeb tub.

Thaum muab tshuaj rau cov tshuaj no rau cov poj niam cev xeeb tub, kev ceev faj yuav tsum yog siv. Nws yog ib qho tsim nyog yuav tsum ua tib zoo ntsuas ntsuas ntshav qabzib.

Cov neeg mob ntshav qab zib muaj mob ntshav qab zib yuav tsum tau soj ntsuam cov ntshav qab zib kom qis. Hauv thawj peb lub hlis, cov kab mob yuav tsum tau poob qis dua me ntsis. Seb cov insulin kis mus rau leej niam mis yog tsis paub.

Tsis txhob hloov cov tshuaj thiab cov tshuaj kho rau lub raum puas.

Cov kev tshawb fawb soj ntsuam hauv cov neeg mob uas muaj lub cev tsis ua haujlwm tsis muaj teeb meem.

Nrog kev tshaj li ntawm kev noj tshuaj ntau dhau, hypoglycemia txhim kho sai sai, thiab nws cov degree yuav txawv - ntawm me me mus rau mob hnyav.

Kev mob ntshav qog ntshav me me yog tso tseg tsis siv hom piam thaj lossis zaub mov qab zib. Nws raug nquahu kom cov neeg mob ib txwm nqa khoom qab zib, ncuav qab zib, kua qab zib, lossis tsuas yog muaj cov piam thaj ua kom huv nrog lawv.

Nrog kev tshaj li ntawm kev noj tshuaj ntau dhau, hypoglycemia txhim kho sai sai, thiab nws cov degree yuav txawv - ntawm me me mus rau mob hnyav.

Nrog ib tus neeg mob ntshav nce siab ntau ntau, ib tug neeg poob qab lawm. Glucagon lossis dextrose raug muab rau hauv kev pabcuam ua ntej. Yog tias tsis muaj qhov tshuaj tiv thaiv rau kev tswj hwm ntawm glucagon, tom qab ntawd tib qho kev txhaj tshuaj dua. Tom qab nws rov qab nco qab, koj yuav tsum muab tshuaj rau tus neeg mob qab zib.

Qee yam tshuaj yuav cuam tshuam rau cov metabolism hauv qabzib. Qhov no yuav tsum muaj kev hloov pauv ntawm cov tshuaj cov kua dej. Cov tshuaj yeeb tshuaj hauv qab no ua rau kom qhov teebmeem hypoglycemic ntawm Apidra:

cov tshuaj hypoglycemic qhov ncauj,
ACE inhibitors
Disopyramides,
fibrates
Fluoxetine,
monoamine oxidase inhibiting tshuaj lom neeg
Pentoxifylline
Propoxyphene,
salicylic acid thiab nws cov derivatives,
sulfonamides.

Cov tshuaj no txo cov hypoglycemic kev ua si ntawm hom insulin no:

GKS,
Danazole
Diazoxide
tshuaj kho mob
Isoniazid,
Phenothiazine derivatives
Kev loj hlob lawm,
cov thyroid hormones analogues
poj niam deev cov tshuaj hormones muaj nyob hauv cov tshuaj tiv thaiv
tshuaj uas inhibit tus protease.

Beta-blockers, clonidine hydrochloride, lithium npaj tuaj yeem txhim kho, los sis, hloov, tsis muaj zog cov kev ua ub no ntawm insulin. Kev siv pentamidine ua ntej ua rau lub qog ntshav qab zib, thiab tom qab ntawd ua rau nce siab ntawm cov ntshav qabzib.

Cov tshuaj insulin tsis tas yuav muab sib xyaw nrog lwm hom ntawm cov tshuaj no hauv tib lub koob txhaj. Tib yam siv rau infusion twj.

Haus cawv ntau yuav ua rau lub ntsej muag ntshav qab zib.

Glulisin analogues suav nrog:

Apidra
Novorapid Flekspen,
Epidera
tshuaj insulin isophane.

Apidra muaj qhov muag tshuaj. Tus mob ntshav qab zib tau txais cov tshuaj dawb.

Tus nqi ntawm rab koob xev hluav taws xob yog kwv yees li 2 txhiab rubles.

Tsis tau qhib lub laub thiab cov vials yuav tsum cia hauv tub yees. Txwv tsis pub tshuaj insulin. Qhib cov vials thiab daim cartridges yog khaws cia hauv qhov kub tsis dhau + 25ºC.

Cov tshuaj no haum rau 2 xyoos. Txee lub neej nyob rau hauv lub raj mis qhib lossis lub taub ntawv thawv yog 4 lub lis piam, tom qab uas nws yuav tsum tau muab pov tseg.

Nws yog tsim ntawm lub chaw lag luam Sanofi-Aventis Deutschland GmbH, Lub Tebchaws Yelemees.

Ivan, 50 xyoo, endocrinologist, Moscow: “Nrog kev pab los ntawm Apidra, nws muaj peev xwm tswj kev mob glycemia hauv cov neeg mob uas muaj ntshav qab zib hom 1. Kuv pom zoo kom muab cov insulin ua ntej noj mov. Nws zoo kawg nkaus extinguishes tau surges hauv qab zib ntsuas. ”

Svetlana, 49 xyoo, kws kho mob ntshav qab zib, Izhevsk: “Glulisin yog ib qho zoo tshaj insulins luv luv. Cov neeg mob zam nws zoo, tab sis raug rau cov khoom tsim thiab ntau dua. Kev mob ntshav siab yog ib qho tsis tshua muaj heev. "

Andrei, 45 xyoo, St. Petersburg: “Glulizin tsis ua rau lub suab thaj txo qis, uas yog qhov tseem ceeb rau kuv ua neeg mob ntshav qab zib nrog“ kev paub ”. Qhov chaw tom qab kev txhaj tshuaj tsis mob lossis nrawm. Tom qab noj mov, cov kua nplaum nyeem cov lus zoo li qub. ”

Olga, 50 xyoo, Tula: “Cov insulins qub ua rau kuv kiv taub hau, thiab thaj tsam txhaj tshuaj mob siab tas li. Glulisin tsis ua rau cov tsos mob no. Nws yog qhov yooj yim los siv cov ntawv txhaj tshuaj thiab qhov tseem ceeb dua, siv tau. "

Lydia, 58 xyoo, Rostov-on-Don: “Ua tsaug rau Glulizin, Kuv khaws ib theem ntxiv suab thaj tom qab noj mov. Kuv nruj me ntsis raws kev noj haus thiab ua tib zoo laij lub koob tshuaj. Tsis muaj qee qhov cuam tshuam txog kev mob ntshav qab zib tsawg. ”

Cov tshuaj insulin Cov lus qhia: cov lus qhia, tshuaj xyuas cov lej, tshuaj yeeb yaj kiab

Mob ntshav qab zib mellitus yog ib qho kab mob txaus ntshai uas tuaj yeem ua tau cov insulin-hom (hom 1) lossis tsis-insulin-yam (hom 2). Hauv rooj plaub tom kawg, tus kab mob tau ua tiav zoo nrog kev pab ntawm hypoglycemic agents thiab tshwj xeeb kev noj haus. Tab sis nrog thawj hom mob thiab nrog ntshav qab zib hom 2 pib, kev kho tshuaj insulin tsis tuaj yeem muaj peev xwm ua kom tsis txhob muaj.

Feem ntau, cov neeg mob uas muaj kev nce siab ntxiv ntawm cov piam thaj hauv cov ntshav yog cov tshuaj insulin Glulizin. Qhov no yog cov tshuaj dawb rau kev txhaj tshuaj, cov tshuaj yeeb dej tseem ceeb ntawm uas yog cov tshuaj sib txuas ntawm tib neeg cov tshuaj insulin, txhim kho siv cov tshuaj engineering.

Cov tshuaj muaj cov nyhuv luv luv txhawm rau qhov txo qis hauv kev saib xyuas cov kua nplaum hauv cov ntshav. Apidra SoloStar thiab Apidra koom nrog txoj hauv kev, uas koom nrog insulin Glulisin.

Kev daws tau luv luv hypoglycemic nyhuv. Tsis tas li ntawd, nws ua kom cov txheej txheem qabzib nqus los ntawm peripheral cov ntaub so ntswg (rog, cov leeg pob txha), txwv txheej txheem cov txheej txheem ntawm cov piam thaj hauv siab.

Cov tshuaj kuj pab txhawb kev ua kom muaj protein ntau, inhibits proteolysis thiab lipolysis hauv adipocytes. Tom qab tswj hwm subcutaneous, qhov txo qis hauv qab zib qib tshwm sim tom qab 10-20 feeb.

Kev tswj hwm ntawm iv kev tswj hwm, cov nyhuv hypoglycemic yog piv rau cov kev ua ntawm tib neeg cov insulin. Yog li, hais txog qhov ua tau zoo, 1 IU ntawm insulin Glulisin yog sib npaug rau 1 IU ntawm solulin tib neeg cov kua dej.

Piv nrog tib neeg cov insulin, Glulisin yog nqus ob zaug kom nrawm dua. Qhov no yog vim muaj kev hloov ntawm asparagine amino acid (txoj haujlwm 3B) nrog lysine, ntxiv rau lysine (txoj haujlwm 29B) nrog glutamic acid.

Kev tsis haum tom qab saib xyuas sc:

hauv tus ncej puab - nruab nrab
hauv phab ntsa plab - nrawm,
nyob rau hauv lub xub pwg - nruab nrab.

Kev tsis raug cai ntawm bioavailability yog 70%. Thaum qhia rau ntau thaj chaw, nws zoo sib xws thiab muaj qhov txawv txav ntawm tus neeg mob (tus nqi hloov ntawm 11%).

Thaum muab tshuaj subcutaneously nrog hom 1 mob ntshav qab zib, 0.15 IU / kg TCmax yog 55 feeb, thiab kg Cmax yog 80.7-83.3 μU / ml. Hauv hom ob, tom qab kev tswj hwm sc ntawm cov tshuaj ntawm ib koob ntawm 0.2 PIECES / kg, Cmax yog 91 mcU / ml.

Hauv cov kab ke ncig tag nrho, lub sijhawm kwv yees kwv yees yog 98 min. Nrog rau / hauv cov lus qhia, qhov ntim ntawm kev faib tawm yog 13 litres, T1 / 2 - 13 feeb. AUC - 641 mg xh / dl.

Cov chaw muag tshuaj rau cov neeg mob ntshav qab zib qis dua 16 xyoo muaj thawj hom mob yog tib yam li cov neeg laus. Nrog sc tswj hwm T1 / 2 yog ntawm 37 txog 75 feeb.

Tshuaj Insulin Glulizin yog muab tshuaj subcutaneously, ntau npaum qhov tau xaiv ib tus zuj zus rau txhua tus neeg mob. Kev txhaj tshuaj yog ua tiav nyob rau hauv 0-15 feeb. ua ntej lossis tom qab noj mov.

Glulisin yog siv rau hauv kev siv tshuaj kho mob, suav nrog kev siv tshuaj insulin hauv nruab nrab lossis ntev ntev, lossis lawv cov analogues. Tsis tas li, cov tshuaj yeeb yaj kiab tuaj yeem siv ua ke nrog cov tshuaj uas muaj cov nyhuv hypoglycemic, uas tau siv los hais lus.

Kev daws yog muab rau hauv daim ntawv ntawm kev txhaj tshuaj subcutaneous los yog infusion siv lub twj tso kua mis. Kev txhaj tshuaj yog ua tiav thaj chaw ntawm lub xub pwg, ncej puab, sab hauv plab phab ntsa. Thiab qhia txog ntawm cov nyiaj los ntawm kev sib txuas ntxiv txuas ntxiv yog nqa tawm hauv peritoneum.

Cov cheeb tsam rau kev txhaj tshuaj thiab infusions yuav tsum tau hloov txhua zaus. Qhov ceev ntawm kev nqus, qhov pib thiab lub sijhawm ntawm cov nyhuv yog txiav txim siab los ntawm ntau yam (kev qoj ib ce, txhaj tshuaj ntawm qhov chaw). Rau kev nqus sai, cov tshuaj yuav tsum tau txhaj rau hauv qhov chaw ntawm sab xub ntiag ntawm phab ntsa plab.

Nws yog ib qho tseem ceeb kom ceev faj tias insulin Glulisin tsis nkag rau cov hlab ntshav. Yog li, txhua tus neeg mob ntshav qab zib yuav tsum txawj ntse nyob rau hauv kev tswj hwm insulin. Tom qab txhaj, qhov chaw txhaj tshuaj txwv tsis pub zaws.

Glulisin raug tso cai muab sib xyaw nrog Isofan (tib neeg insulin), tab sis Glulisin yuav tsum tau kos rau hauv cov koob txhaj tshuaj ua ntej. SC cov thawj coj yuav tsum tau ua tam sim ntawd tom qab sib xyaw cov nyiaj. Hauv qhov no, sib xyaw ntawm Isofan thiab Glulisin yog txwv tsis pub muab cov tshuaj tso ntshav.

Yog tias cov tshuaj insulin Glulisin siv cov twj tso kua mis, tom qab ntawd cov khoom siv yuav tsum tau hloov pauv txhua 4 teev, ua raws li cov kev cai tiv thaiv kev lag luam. Nrog rau txoj kev lis ntshav ntawm txoj kev tswj hwm, cov tshuaj yuav tsum tsis txhob sib xyaw nrog lwm cov kev daws teeb meem lossis insulins.

Kev siv tsis zoo ntawm lub twj tso kua mis los yog ua txhaum nws txoj haujlwm, ntshav qab zib ketoacidosis, hyperglycemia lossis ketosis tuaj yeem txhim kho. Txhawm rau tiv thaiv qhov tshwm sim ntawm cov xwm txheej zoo li no, ua ntej yuav ua tus txheej txheem, koj yuav tsum ua tib zoo kawm kev cai rau kev siv qhov system thiab ua tib zoo suav kev siv tshuaj noj.

Ua ntej siv txoj kev daws teeb meem, koj yuav tsum xyuas nws qhov xwm yeem, xim thiab paub tseeb tias tsis muaj cov khoom txawv teb chaws hauv nws. Yog tias cov khoom yog pos huab, xim lossis nrog nrog qhov tsis zoo, ces nws raug txwv tsis pub siv.

Kev siv tshuaj Insulin Glulizin tsis yog siv los kho cov menyuam yaus hnub nyoog qis dua 6 xyoo, muaj kev mob ntshav qab zib thiab kev tiv thaiv tsis zoo rau nws cov khoom xyaw. Cov kev mob tshwm sim feem ntau yog hypoglycemia. Cov tawv nqaij ua xua tshwm sim thiab cov teeb meem ntawm lub cev zom zaub mov kuj tseem muaj peev xwm ua tau.

Qee zaum cov tsos mob neuropsychiatric xws li tsaug zog, nkees, pheej ua tsis muaj zog, cramps, thiab xeev xeev tau tshwm sim. Mob taub hau, tsis muaj peev xwm siab, tsis meej pem meej pem thiab pom kev tsis meej pem kuj tshwm sim.

Feem ntau, ua ntej neuropsychiatric ntshawv siab, cov tsos mob ntawm adrenergic txee-kev tswj hwm tshwm sim. Qhov no yog kev tshaib kev nqhis, txob taus, tachycardia, tshee tshee zoo, tawm hws txias, ntxhov siab, blanching ntawm daim tawv nqaij thiab tshee.

Nws yog tsim nyog sau cia tias muaj kev tawm tsam hnyav ntawm hypoglycemia, uas ib txwm ua tas li, ua rau kev puas tsuaj rau NS. Ntxiv mus, hauv qee kis, qhov no yuav ua rau tuag.

Ntxiv nrog rau qhov poob qis hauv cov suab thaj, cov kev mob tshwm sim hauv ib cheeb tsam kuj yuav tshwm sim hauv cov cheeb tsam uas tau txhaj koob tshuaj. Cov no suav nrog hyperemia, o thiab khaus, feem ntau cov tsos mob ploj lawv tus kheej thaum kho ntxiv. Qee zaum, vim yog qhov tsis ua raws li kev hloov chaw ntawm chaw tswj hwm ntawm cov tshuaj insulin, ib qho ntshav qab zib yuav mob lipodystrophy.

Cov cim qhia ntsig txog qhov tsis nco qab yog qhov ua tau:

khaus
urticaria
dermatitis ua xua,
hauv siab nruj
zawm caj pas.

Cov ua xua tsis haum yuav ua tau neeg tuag taus.

Yog tias dhau ntawm kev siv tshuaj ntau dhau, mob ntshav qab zib ntawm qhov sib txawv yuav tshwm sim. Nrog rau cov ntshav qab zib kom tsawg, tus neeg mob yuav tsum haus dej haus lossis cov khoom muaj suab thaj.

Nrog rau kev mob hnyav dua thiab tsis nco qab, s / c lossis v / m raug tswj hwm Dextrose lossis Glucagon. Thaum tus neeg mob rov qab nco qab, nws yuav tsum noj cov khoom noj carbohydrates, uas yuav zam kom tsis txhob mob huam ntxiv.

Kev piav qhia ntawm cov tshuaj nquag nquag Insulin glulisin / Insulinum glulisinum.

Cov mis C258H384N64O78S6, tshuaj lub npe: tsis muaj ntaub ntawv.
Pharmacological pawg: cov tshuaj hormones thiab lawv cov antagonists / insulins.
Pharmacological kev txiav txim: tshuaj qog ntshav.

Mob ntshav qab zib mellitus, uas yuav tsum muaj kev siv tshuaj insulin, rau cov laus thiab cov menyuam yaus hnub nyoog tshaj li 6 xyoo.

Cov tshuaj tiv thaiv tsis haum rau cov tshuaj insulin glulisin (suav nrog rau qhov tsis haum rau qee yam ntawm cov tshuaj ntawm cov tshuaj), mob ntshav qab zib, muaj hnub nyoog txog 6 xyoo.

Cev xeeb tub, pub niam mis.

Cov npe lag luam rau cov tshuaj uas muaj yam tshuaj insulin glulisin

Apidra®
Apidra® SoloStar®
Cov tshuaj insulin glulisin

Moroz B. T., Khromova E. A., Shustov S. B., li al. Kev siv thev naus laus zis tshiab tshiab hauv kev kho cov nyom ntawm cov neeg mob uas muaj ntshav qab zib hom 2, mauitus, Nauka Lub Tsev Luam Ntawv - M., 2012. - 160 p.
Bogdanova, O. Cov Phau Ntawv Diabetes Loj. Txhua yam koj yuav tsum paub txog ntshav qab zib / O. Bogdanova, N. Bashkirova. - M .: AST, AST Moscow, Prime-Evroznak, 2008. - 352 p.
Phau ntawv qhia txog khoom noj muaj ceem, Lub Tsev Tsim Kev Ntsuas Kev Tsim Vaj Tsev UNIZDAT - M., 2015. - 366 c.

Cia kuv qhia kuv tus kheej. Kuv lub npe yog Elena. Kuv tau ua haujlwm li endocrinologist rau ntau tshaj 10 xyoo. Kuv ntseeg hais tias tam sim no kuv yog tus kws tshaj lij hauv kuv daim teb thiab kuv xav pab txhua tus neeg tuaj xyuas lub vev xaib kom daws qhov nyuaj thiab tsis yog li cov haujlwm. Txhua cov ntaub ntawv rau lub xaib tau sau thiab ua tib zoo ua kom tiav thiaj li xa ntau li ntau tau cov ntaub ntawv tsim nyog. Ua ntej thov cov ntaub ntawv uas tau piav qhia hauv lub vev xaib, yuav tsum tau sab laj nrog tus kws kho mob tshwj xeeb.

Txoj kev ntawm kev siv thiab contraindications

Glulisin yog qhov ua kom insulin tib neeg tsim tawm, txawm li cas los xij, nws cov potency yog sib npaug ntawm cov insulin tib neeg. Cov tshuaj pib ua haujlwm sai dua, tab sis nrog kev ncua sijhawm luv. Twb tau 10-20 feeb tom qab txhaj tshuaj subcutaneous, cov ntshav qab zib yuav hnov mob ntau dua.

Ntxiv rau kev txhaj tshuaj subcutaneous, cov tshuaj glulisin tuaj yeem raug tswj hwm los ntawm kev txuas ntxiv mus rau hauv cov rog subcutaneous uas siv lub tshuab nqus insulin. Kev txhaj tshuaj yog qhov zoo tshaj plaws ua tiav sai lossis sai sai tom qab koj noj mov.

Kev txhaj tshuaj subcutaneous yuav tsum ua rau ntawm lub xub pwg, lub duav lossis lub plab. Yog tias peb tab tom tham txog kev txuas ntxiv infusions, tom qab ntawd lawv tau ua rau hauv lub plab nkaus xwb.

Kev siv cov tshuaj tsis pom zoo hauv cov xwm txheej no:

cov me nyuam muaj hnub nyoog
ntshav qab zib,
ntev rhiab heev.

Insulin Glulizin muaj feem xyuam siv rau kev kho mob, uas muab rau cov tshuaj insulin ntawm nruab nrab lossis ntev ntev. Cov tshuaj no yog siv ua ke nrog lwm cov neeg muaj kabmob hypoglycemic hauv ntsiav tshuaj hom, thiab tseem raug tswj siv siv cov tshuaj insulin.

Cov cim ntawm cov kev phiv tshuaj

Cov kev xav tsis zoo tom qab siv cov tshuaj yuav tshwm sim:

ntau dhau rhiab, piv txwv li, o, khaus thiab liab ntawm lub chaw ntawm kev tswj hwm. Cov kev xav zoo li no, raws li txoj cai, tag nrho ploj nrog kev kho ntev. Hauv qee kis, kev tshwm sim ntawm lipodystrophy (teeb meem ntawm daim tawv nqaij los ntawm kev ua txhaum ntawm kev hloov chaw ntawm kev tswj hwm ntawm cov tshuaj) yog ua tau,
kev ua xua (ua pa luv, ua xua dermatitis, urticaria, khaus, nti nyob hauv lub ntsws),
kev tsis haum tshuaj (txog kev poob siab anaphylactic).

Ntau tus neeg mob

Tam sim no, cov tshuaj tsis muaj cov ntaub ntawv ntawm kev siv tshuaj ntau dhau los, txawm li cas los xij, hypoglycemia ntawm ntau qhov kev xav tau yog theoretically tau.

Kev ncua sij hawm ntawm kev haus me ntsis ntau dhau tuaj yeem nres siv cov zaub mov muaj piam thaj lossis piam thaj. Vim li no, txhua tus neeg mob ntshav qab zib yuav tsum muaj ib qho me me ntawm qab zib nrog nws.

Nrog rau mob hnyav thiab cuam tshuam ntawm kev nco qab hypoglycemia, nws muaj peev xwm kom nres tus txheej txheem los ntawm kev siv tshuaj intramuscular lossis subcutaneous ntawm glucagon thiab tso leeg ntshav dextrose.

Tom qab nws rov qab nco qab, tus neeg mob yuav tsum tau haus cov zaub mov carbohydrates. Qhov no yuav ua rau nws muaj peev xwm tiv thaiv qhov rov qab txhim kho ntawm hypoglycemia.

Cov yam ntxwv ntawm kev siv tshuaj

Yog hais tias Glulisin siv nrog rau cov tshuaj hauv qab no, ces cov tshuaj insulin tuaj yeem txhim kho cov kev mob hypoglycemic thiab ua rau muaj kev pheej hmoo ntawm kev txhim kho hypoglycemia:

cov tshuaj tiv thaiv hypoglycemic qhov ncauj,
disopyramids
ACE inhibitors
fibrates
MAO inhibitors
salicylates,
sulfonamides,
propoxyphene.

Thaum muab cov tshuaj insulin nrog danazol, salbutamol, isoniazides, diazoxide, phenothiazine derivatives, somatropin, diuretics, epinephrine, terbutaline, protease inhibitors, tshuaj tiv thaiv tshuaj tiv thaiv, Glulizin yuav txo cov nyhuv hypoglycemic.

Kev siv cov beta-blockers, lithium ntsev, ethanol thiab clonidine tuaj yeem txo cov nyhuv ntawm cov tshuaj insulin Glulizin. Pentamidine tseem ua rau ob leeg cov hypoglycemia thiab hyperglycemia uas tshwm sim los ntawm nws.

Kev siv cov sympatholytic kev npaj ua haujlwm muaj peev xwm los ua ntsej muag cov tsos ntawm adrenergic reflex activation. Cov no suav nrog guanethidine, clonidine.

Muab tus neeg mob hloov mus rau lwm hom tshuaj insulin (lossis rau cov tshuaj los ntawm cov chaw tsim khoom tshiab), nws yuav tsum tau txais kev saib xyuas mob nruj me ntsis. Qhov no tseem ceeb nyob rau hauv kev xav ntawm qhov yuav xav tau kev hloov kho ntawm txoj kev kho.

Noj cov tshuaj tsis raug ntawm cov tshuaj insulin Glulisin lossis kev txiav tu ncua ntawm kev kho mob ua rau muaj kev txhim kho sai ntawm hypoglycemia thiab ntshav qab zib ketoacidosis (muaj kev phom sij hauv lub neej).

Lub sijhawm ntawm kev txhim kho ntawm lub xeev hypoglycemic yuav nyob ntawm qhov ceev ntawm qhov pib ntawm kev ua ntawm cov tshuaj uas siv thiab yuav hloov nrog kev kho ntawm kev kho mob kiag li.

Muaj qee yam kev mob uas yuav hloov lossis ua rau cov neeg pheej pehawm ntawm cov ntshav qog ntshav qab zib tsawg dua, piv txwv li:

uas neuropathy mob ntshav qab zib,
intensification ntawm kev kho mob nrog insulin,
lub sijhawm ua ntshav qab zib
kev siv qee yam tshuaj
kev hloov ntawm tus neeg mob los ntawm tsiaj mus rau tib neeg cov tshuaj insulin.

Hloov pauv ntawm txoj kev noj tshuaj ntawm cov tshuaj insulin Glulisin yog qhov tsim nyog thaum hloov pauv kev noj mov lossis hloov lub cev lub cev. Kev tawm dag zog lub cev tam sim ntawd tom qab noj mov tag yuav muaj kev phom sij ntawm lub qog ntshav qab zib.

Yog hais tias luv luv insulin txhaj, qhov kev txo qis tseem ceeb nyob rau hauv cov concentration ntawm cov piam thaj hauv cov ntshav tau pom ntau sai dua thaum siv soluble tib neeg cov insulin.

Kev tsis pom qhov tsis txaus hypoglycemia thiab hyperglycemic tshua tuaj yeem yog qhov yuav tsum tau ua ntej rau kev tsis nco qab, kev txhim kho ntawm coma, thiab tuag!

Siv thaum cev xeeb tub thiab lactation

Cov poj niam cev xeeb tub yuav tsum siv cov tshuaj insulin Glulisin nyob rau hauv kev saib xyuas ntawm kws kho mob thiab raug soj ntsuam cov ntshav qab zib.

Thaum lub sijhawm pub niam mis, cov tshuaj tsis tuaj yeem nkag rau hauv cov mis, thiab yog li ntawd raug pom zoo rau kev siv. Thaum lactation, nws yog qhov tsim nyog yuav tau hloov kho cov tshuaj thov ntawm cov tshuaj tau txais txiaj ntsig. Tsis tas li, kev hloov tshuaj ntau npaum li cas yuav muaj feem cuam tshuam nrog kev mob siab rau ntau tshaj thiab qhov mob nyhav.

Pharmacological nyhuv thiab pharmacokinetics

Kev tsis haum tom qab saib xyuas sc:

hauv tus ncej puab - nruab nrab
hauv phab ntsa plab - nrawm,
nyob rau hauv lub xub pwg - nruab nrab.

Kev tsis raug cai ntawm bioavailability yog 70%. Thaum qhia rau ntau thaj chaw, nws zoo sib xws thiab muaj qhov txawv txav ntawm tus neeg mob (tus nqi hloov ntawm 11%).

Hauv cov kab ke ncig tag nrho, lub sijhawm kwv yees kwv yees yog 98 min. Nrog rau / hauv cov lus qhia, qhov ntim ntawm kev faib tawm yog 13 litres, T1 / 2 - 13 feeb. AUC - 641 mg xh / dl.

Cov chaw muag tshuaj rau cov neeg mob ntshav qab zib qis dua 16 xyoo muaj thawj hom mob yog tib yam li cov neeg laus. Nrog sc tswj hwm T1 / 2 yog ntawm 37 txog 75 feeb.

Cov lus qhia rau kev siv tshuaj

Cov kev txuam nrog, phiv ntau dhau, siv ntau dhau

Nws yog tsim nyog sau cia tias muaj kev tawm tsam hnyav ntawm hypoglycemia, uas ib txwm ua tas li, ua rau kev puas tsuaj rau NS. Ntxiv mus, hauv qee kis, qhov no yuav ua rau tuag.

Cov cim qhia ntsig txog qhov tsis nco qab yog qhov ua tau:

khaus
urticaria
dermatitis ua xua,
hauv siab nruj
zawm caj pas.

Cov ua xua tsis haum yuav ua tau neeg tuag taus.

Nrog rau kev mob hnyav dua thiab tsis nco qab, s / c lossis v / m raug tshuaj Dextrose lossis Glucagon. Thaum tus neeg mob rov qab nco qab, nws yuav tsum noj cov khoom noj carbohydrates, uas yuav zam kom tsis txhob mob huam ntxiv.

Luv luv txog insulin Glulizin

Insulin Glulisine yog ib qho piv txwv ntawm tib neeg cov kua dej, uas zoo sib xws hauv txoj ntsiab cai rau cov tshuaj no. Tab sis los ntawm xwm, nws ua tau nrawm dua thiab muaj cov qauv luv luv.

Glulisin tau nthuav tawm raws li kev daws teeb meem rau kev tswj hwm ntawm subcutaneous. Nws zoo nkaus li ua kua pob tshab tsis muaj impurities.

Cov npe lag luam rau cov tshuaj uas nws muaj: Apidra, Epidera, Apidra Solostar. Lub hom phiaj tseem ceeb ntawm cov tshuaj yog mus tswj cov metabolism hauv qabzib.

Raws li kev paub dhau los, qhov zoo thiab tsis zoo hauv qab no tuaj yeem sib txawv:

ua nrawm dua li tib neeg hormone (+),
zoo txaus siab qhov xav tau khoom noj hauv cov kua dej (+),
peev xwm tsis muaj kev cuam tshuam ntawm cov nyhuv ntawm cov tshuaj ntawm cov piam thaj (-),
siab zog - chav tsev txo cov suab thaj ntau dua li lwm cov insulins (+).

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Nrog kev qhia txog Glulisin thiab cov insulin tsis tu ncua ob peb feeb ua ntej noj mov, yav tas los ua kom zoo dua glycemic tswj tom qab noj mov. Lub bioavailability ntawm yam khoom yog li 70%.

Kev sib txuas lus nrog cov protein ntshav yog negligible. Nws yog tawm me ntsis sai dua li niaj zaus kev txhaj tshuaj tib neeg. Ib nrab-lub neej ntawm 13,5 feeb.

Kev ntsuas, phiv ntau tshaj, haus dej ntau dhau

Ib yam tshuaj raug xaj nyob rau qee yam hauv qab no:

Yam 1 ntshav qab zib
Ntshav Qab Zib Hom 2,
Mob ntshav qab zib hauv cov menyuam yaus txij li 6 xyoo.

Cov tshuaj tiv thaiv kom tsis txhob xaiv lub sijhawm tshuaj yog li nram qab no:

ntshav qab zib,
hypersensitivity rau glulisin,
hypersensitivity rau ntu ntu ntawm cov tshuaj.

Hauv chav kawm ntawm kev kho nrog tshuaj, phiv tshuaj tuaj yeem tshwm sim.

Qhov nquag ntawm cov xwm txheej tsis zoo hauv cov lej, qhov twg 4 yog qhov muaj ntau, 3 feem ntau, 2 yog tsawg, 1 tsawg tsawg:

Thaum lub caij noj tshuaj ntau dhau hwv lawm, kev soj ntsuam ntshav lub qog ntshav qis. Nws tuaj yeem tshwm sim yuav luag tam sim ntawd lossis txhim kho maj mam.

Nrog cov ntshav qog ua kom qis thiab ntshav qab zib kom qis, cov khoom qab zib uas muaj suab thaj yog noj. Hauv cov mob hnyav, uas nrog nrog tsis nco qab, yuav tau txhaj tshuaj.

Yeeb tshuaj sib cuam tshuam

Thaum pib ntawm kev kho mob nrog ultrashort insulin, nws txoj kev cuam tshuam nrog lwm cov tshuaj noj tau coj los ua.

Cov lus qhia tshwj xeeb

Tus neeg mob yuav tsum xav txog cov hauv qab no:

Nrog lub raum ua haujlwm lossis ua txhaum hauv lawv txoj haujlwm, xav tau cov tshuaj insulin yuav tsawg dua.
Nrog lub siab ua haujlwm ntawm lub siab, qhov xav tau kuj poob qis.
Vim tias tsis muaj cov ntaub ntawv, cov tshuaj tsis raug txwv rau cov menyuam yaus hnub nyoog qis dua 6 xyoo.
Siv nrog ceev faj nyob rau hauv cov poj niam cev xeeb tub nrog nquag saib xyuas ntawm ntsuas.
Thaum lub sijhawm lactation, koob tshuaj thiab kev noj haus kev kho mob yuav tsum muaj.
Thaum hloov mus rau Glulisin los ntawm lwm qhov tshuaj tiv thaiv vim muaj qhov tsis haum lub cev, kev ntsuas tshuaj tiv thaiv ua xua yuav tsum tau ua kom tsis txhob sib xyaw khaub thuas.

Tsuas tshuaj kho kom haum

Cov txheej txheem yog tswj hwm nrog kev pab ntawm ntsiav tshuaj hypoglycemic tshuaj. Yog tias koj hloov ib qho twg hauv cov phiaj xwm, koj yuav tau kho qhov tshuaj ntawm Glulisin.

Feem ntau ntawm hyperglycemia / hypoglycemia, cov tshuaj tiv thaiv kab mob hauv qab no yog qhov tau teev ua ntej hloov pauv kev noj tshuaj:

cov txheej txheem thiab qhov chaw siv tshuaj yaj yeeb,
nruj mas ua raws cov txheej txheem kho mob,
kev noj lwm yam tshuaj rau hauv parallel
psycho-txoj kev xav lub xeev.

Cov Ntaub Ntawv Ntxiv

Txee lub neej tom qab qhib - lub hli

Cia - ntawm t ntawm +2 txog + 8ºC. Tsis khov!

Lub sijhawm so haujlwm yog mus tshuaj.

Glulisin yog qhov piv rau tib neeg cov tshuaj insulin:

Insuman Sai Sai,
Neeg lim hiam
Neej Neeg Dab
Gensulin P,
Vosulin P,
Actrapid.

Pom zoo Lwm Yam Lus Txog

Pharmacological kev txiav txim

Cov tshuaj yog siv tshuaj yaj yeeb ntawm tib neeg cov tshuaj insulin. Lub zog ntawm kev nqis tes ua zoo ib yam li cov tshuaj hormones uas tsim los ntawm kev noj qab haus huv txiav zoo. Glulisin ua tau nrawm dua thiab muaj lub sijhawm ntev.

Tom qab kev tswj hwm rau lub cev (subcutaneously), qhov tshuaj hormones pib tswj cov metabolism metabolism.

Cov kev tshawb fawb soj ntsuam pom tias glulisin, siv 2 feeb ua ntej noj mov, muab tib qho kev tswj cov piam thaj hauv ntshav li tib neeg cov tshuaj insulin, muab ib nrab ib teev ua ntej noj mov.

Kev ua haujlwm ntawm insulin tsis hloov pauv ntawm cov neeg sib txawv ntawm ntau haiv neeg.

Cov Tshuaj Pharmacokinetics

Yuav ua li cas noj insulin glulisin?

Nws yog noj subcutaneously 0-15 feeb ua ntej noj mov. Qhov kev txhaj tshuaj yog tsim nyob rau hauv lub plab, ncej puab, xub pwg. Tom qab txhaj tshuaj, koj tuaj yeem tsis zaws thaj chaw txhaj tshuaj. Koj tsis tuaj yeem sib xyaw ntau hom tshuaj insulin nyob rau hauv tib lub koob txhaj, txawm hais tias tus neeg mob yuav tau txais cov tshuaj insulins sib txawv. Kev thim rov qab ntawm cov tshuaj ua ntej nws cov kev tswj hwm tsis pom zoo.

Cov cai hais txog siv rab koob xaum hluav taws xob

Yog tias tus nqus dej tsis ua hauj lwm zoo, tom qab kev daws teeb meem tuaj yeem kos los ntawm daim cartridge mus rau hauv cov phwj.

Cov kev mob tshwm sim ntawm insulin glulisin

hws no
pallor thiab txias ntawm daim tawv nqaij,
mloog zoo li nkees heev
kev zoo siab
pom kev tsis sib to taub
tshee hnyo
zoo kawg li ntxhov siab vim
tsis meej pem, nyuaj mloog,
lub zog hnov mob hauv cov mob taub hau,
palpitations.

Kev muaj ntshav qab zib ntau ntau yuav nce ntxiv. Qhov no yog lub neej hem, vim nws ua rau muaj kev cuam tshuam loj heev ntawm lub hlwb, thiab nyob rau hauv cov mob hnyav - tuag.

Ntawm ib sab ntawm daim tawv nqaij

Muaj tsawg kawg uas qhov tshuaj muaj peev xwm ua rau muaj kev tsis haum tshuaj.

Siv thaum cev xeeb tub thiab lactation

Tsuas muaj pov thawj tsawg txog kev siv cov tshuaj no thaum xeeb tub thiab pub niam mis. Kev tshawb nrhiav tsiaj ntawm cov tshuaj tsis tau qhia txog txhua tus neeg hauv lub cev xeeb tub.

Thaum muab tshuaj rau cov tshuaj no rau cov poj niam cev xeeb tub, kev ceev faj yuav tsum yog siv. Nws yog ib qho tsim nyog yuav tsum ua tib zoo ntsuas ntsuas ntshav qabzib.

Glulisin insulin overdose

Nrog kev tshaj li ntawm kev noj tshuaj ntau dhau, hypoglycemia txhim kho sai sai, thiab nws cov degree yuav txawv - ntawm me me mus rau mob hnyav.

Cawv tau zoo

Haus cawv ntau yuav ua rau lub ntsej muag ntshav qab zib.

Glulisin analogues suav nrog:

Apidra
Novorapid Flekspen,
Epidera
tshuaj insulin isophane.

Novorapid (NovoRapid) - ib qho lus piv txwv ntawm tib neeg cov tshuaj insulin

Isofan insulin noj (Isofan insulin)

Ua li cas thiab thaum twg los tswj cov tshuaj insulin? Cov txheej txheem txhaj tshuaj thiab tshuaj insulin

Chaw tsim tshuaj paus

Nws yog tsim ntawm lub chaw lag luam Sanofi-Aventis Deutschland GmbH, Lub Tebchaws Yelemees.

Svetlana, 49, kws kho mob ntshav qab zib, Izhevsk: “Glulizin yog ib qho zoo tshaj plaws ntawm insulin. Cov neeg mob zam nws zoo, tab sis raug rau cov khoom tsim thiab ntau dua. Kev mob ntshav siab yog ib qho tsis tshua muaj heev. "

Cov tshuaj pleev insulin (Cov kua dej hauv tsev): cov npe lag luam, cov yam ntxwv, cov lus qhia rau kev siv

Ntawm hom ntshav qab zib hom 1, tus neeg mob tuaj yeem siv cov kev siv tshuaj sai (sai), luv luv, nruab nrab, ua kom ntev thiab muaj cov tshuaj tiv thaiv ua ntej. Qhov twg yog qhov tau sau tshuaj rau kev noj tshuaj kom zoo txaus nyob ntawm tus neeg yam ntxwv ntawm lub cev. Yog tias koj xav tau cov tshuaj insulin ultrashort, Glulisin siv.

Cov tshuaj txhaj hu ua "Insulin Glulisin" yog yuav hauv khw muag tshuaj los ntawm cov neeg mob uas muaj ntshav qab zib.

Cov tshuaj no yog tseev kom neeg txo lawv cov ntshav qab zib kom siab, thiab ntxiv rau, kho tus kabmob no. Qhov no yog, ua ntej txhua yam, luv insulin.

Nws yog qhov sib xyaw ntawm lwm cov tshuaj rau cov neeg mob ntshav qab zib. Qhov tshuaj yeeb dej caw no muaj cov lus qhia hypoglycemic.

Qhov no yog ib qho piv txwv ntawm tib neeg cov kua dej, uas zoo sib xws hauv txoj ntsiab cai rau cov tshuaj no. Tab sis los ntawm nws cov xwm, nws ua kom nrawm dua thiab muaj lub sijhawm luv luv.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj no tau siv subcutaneously 15 feeb ua ntej noj mov. Tsuas tshuaj yog xaiv ib tus zuj zus.

Nws yog qhov ua tau los siv kev siv lub twj tso kua mis-ua haujlwm. Txhua hnub tib neeg xav tau cov tshuaj insulin feem ntau yog 0.5 ntsuas. ib kilo ntawm cov huab hwm coj: ntawm no, ob feem peb yog cov tshuaj insulin tam sim ua ntej noj zaub mov. Thiab ib feem peb yog nyob hauv keeb kwm tshuaj insulin (keeb kwm).

Cov tshuaj "Apidra" ("Epidera"): lus piav qhia

Cia peb xav txog cov tshuaj no hauv kev nthuav dav ntxiv.

Apidra insulin yog siv los kho mob ntshav qab zib hauv menyuam yaus txij thaum muaj hnub nyoog 6 xyoo, thiab nws kuj tseem siv rau cov laus. Qhov kev npaj muaj 3.49 milligrams ntawm lub ntsiab.

Txoj kev tivthaiv no tuaj yeem sib piv nrog 100 IU (Cov Tsev Kawm Hauv Tebchaws Thoob Ntiaj Teb) ntawm tib neeg cov tshuaj hormones.

Ntu cov khoom xyaw suav nrog kev txhaj tshuaj dej nrog rau m-cresol, chloride thiab sodium hydroxide, concentrated hydrochloric acid, trometamol thiab polysorbate.

Apidra insulin yog muag hauv lub raj mis 10-milliliter lossis hauv 3-milliliter cartridges. Qhov kev xaiv thawj yog tau ntim rau hauv lub thawv ntawv thawv, thiab lub thib ob yog muab tso rau hauv contour ntim nrog cov hlwb. Nyob rau hauv rooj plaub tom kawg, muaj tsib daim cartridges uas raug them mus rau hauv cov cwj mem tshwj xeeb (uas yog koob txhaj), uas yog hu ua "OptiPen" (qhov no yog qhov cwj mem pov tseg).

Cov tuam txhab tsim khoom tseem ua cov OptiKlik cartridge sib cais. Kiag li ntawm txhua lub ntim muaj cov kua ntshiab uas tsis muaj xim.

Apidra SoloStar

Cov nquag ua si hauv nws yog tam sim no hauv tib cov nyiaj ib yam li hauv kev xaiv yav dhau los. "Insulin glulisin" nrog lub npe lag luam "Apollo hom SoloStar" muaj cov nram qab no contraindications:

Muaj nyob rau hauv cov neeg mob ntawm kev mob ntshav qab zib thiab kev ua haujlwm tsis zoo hauv lub cev mus rau hauv lub hauv paus lossis cov tshuaj pab ntawm cov tshuaj no.
Lub sijhawm lub sijhawm menyuam yaus yog nce mus txog rau xyoo.

Cov tshuaj Apidra thiab Apidra Solostar tuaj yeem muas tau hauv txhua lub tsev muag tshuaj.

Lub subtleties ntawm kev siv cov tshuaj no

"Insulin glulisin" yuav luag zoo tib yam rau tib neeg. Muaj kev zam tshwj xeeb yog lub sijhawm ua kom ntev, uas luv npaum li cas. Nws yog qhov txaus los muab rau tus neeg mob tsuas yog ib qho txhaj tshuaj ntawm cov tshuaj no, xws li tom qab 15 feeb nws yuav muaj lub siab xav pab hauv nws tus mob.

Txoj kev tawm tswv yim kuj sib txawv. Piv txwv li, tus neeg sawv cev no raug txhaj tshuaj subcutaneously rau hauv thaj chaw tshwj xeeb thiab tom qab ntawd, nrog kev siv lub twj tso kua mis, txoj kev ua tiav tas. Txoj kev lis ntshav tuaj yeem ua tau yam tsis muaj kev cuam tshuam, uas yog ua rau hauv cov rog ua kom ncaj ncaj rau hauv daim tawv nqaij.

Cov txheej txheem yuav tsum tau ua txawm tias ua ntej noj mov lossis tom qab, tab sis tsis sai. Kev txhaj tshuaj subcutaneous zoo tshaj plaws nyob hauv thaj chaw mob plab, tab sis kuj tau tso cai rau hauv lub xub pwg, thiab tus ncej puab kuj tseem haum. Tab sis Txoj kev lis ntshav tuaj yeem ua tau tshwj xeeb hauv lub plab. Tsuas yog kws kho mob tuaj yeem sau ntawv kho tus mob. Cov tshuaj no yog siv los tswj cov tshuaj insulin nrog lub sijhawm ntev lossis nruab nrab.

Nws raug tso cai los sib xyaw ua ke ntawm "Insulin glulisin" nrog rau cov ntsiav tshuaj (kev siv tshuaj tiv thaiv hypoglycemic).

Qhov ntau thiab tsawg ntawm kev xaiv cov tshuaj yog txiav txim los ntawm tus kws kho mob koom, vim tias tus neeg mob tsis muaj cai xaiv nws tus kheej. Qhov tseeb yog tias qhov no yog fraught nrog tsis pom qhov tsis zoo.

Ntawm cov lus qhia tseem ceeb rau kev siv, koj tseem tuaj yeem nrhiav cov lus pom zoo rau thaj tsam ntawm kev tswj hwm tshuaj. Nws yog ib qho tseem ceeb los tiv thaiv kev puas tsuaj rau cov hlab ntsha.

Dab tsi ntxiv yog cov lus qhia rau kev siv nrog Insulin Glulizin?

Sab sij hawm ntawm daim ntawv thov

Lub hauv nruab nrab hauv lub paj hlwb, zoo ib yam li cov khoom siv ntu, tuaj yeem teb rau Insulin Glulisine los ntawm kev ua kom cov ntshav qabzib nyob qis thaum pib kho. Qhov pib ntawm mob mob neuropathy yog ua tau, uas yuav txawv hauv qhov hloov chaw. Ntawm cov tshuaj tiv thaiv mob dermatological, nws tsim nyog hais txog lipodystrophy ntawm qhov chaw txhaj tshuaj ntawm cov tshuaj no.

Cov kev paub hauv nruab nrog cev tuaj yeem teb tau nrog qhov ua yuam kev tsis zoo, thiab ntxiv rau, qhov txo qis ntawm qhov pom ntawm qhov muag, uas tseem yuav cuam tshuam nrog kev ceev nrawm ntawm qhov pom ntawm cov piam thaj hauv cov ntshav thaum pib kho. Tus mob no yuav dhau mus. Ua ib feem ntawm kev siv cov cuab yeej no, kev fab tshuaj tsis raug cais tawm.

Kho nyhuv

Glulin insulin yog ib qho tshuaj (ua ke rov los) ntawm tib neeg cov tshuaj insulin. Lub zog ntawm nws kev ua yog sib npaug ntawm cov neeg insulin zoo tib yam. Glulisin pib sai dua, tab sis muaj lub sijhawm luv dua li soluble tib neeg cov kua dej.

Cov tshuaj insulin glulisin txhaj rau hauv qab daim tawv nqaij ua tom qab 10-20 feeb.

Cov txheej txheem ntawm kev tswj hwm ntawm insulin glulisin yog kev txhaj tshuaj subcutaneous los yog kev txuas ntxiv mus rau hauv lub cev subcutaneous rog ntawm lub plab los ntawm lub twj tso kua mis. Tshuaj Insulin yog muab sijhawm luv (0-15 feeb.) Ua ntej lossis sai sai tom qab noj mov.

Mob ntshav qab zib mellitus xav tau kev kho mob insulin.

Sab sij huam

Cov tshuaj tiv thaiv kab mob hauv ib puag ncig hauv zos (liab, o lossis khaus ntawm qhov chaw txhaj tshuaj). Cov kev ua zoo li no feem ntau yog ua dhau los, ploj mus nrog kev kho mob txuas ntxiv. Qee lub sij hawm muaj qhov tshwm sim ntawm lipodystrophy (nyob rau hauv kev ua txhaum ntawm kev hloov chaw ntawm kev txhaj tshuaj nyob hauv tib thaj chaw).

Kev ua xua rau kev ua xua (urticaria, ua tsis taus pa ua pa, bronchospasm, khaus, ua xua tuaj yeem ua xua), suav nrog cov mob hnyav ntawm kev tsis haum tshuaj (suav nrog anaphylactic), uas tuaj yeem tsim kev phom sij rau lub neej.

SAWV DAWS SAWV DAWS

«Cib Toom"- ib qho kev ua tau lub zog antioxidant hnyav uas muab lub neej tshiab zoo rau ob qho tib si metabolic syndrome thiab ntshav qab zib. Qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj yog qhov tseeb tau hais tawm. Cov tshuaj yog pom zoo rau kev siv los ntawm Lavxias Kev Ntshav Qab Zib Association. Tshawb nrhiav ntxiv >>>