Ciprofloxacin-AKOS Ciprofloxacin

Qhov muag poob qis 0.3% nyob rau hauv daim ntawv ntawm kev daws meej ntawm cov xim daj lossis daj-ntsuab.

Tshwjxeeb: disodium ntsev ntawm ethylenediaminetetraacetic acid, mannitol lossis mannitol, sodium acetate anhydrous lossis peb-dej, glacial acetic acid, benzalkonium chloride, dej d / thiab.

5 ml - polyethylene dropper lub raj mis (1) - pob khoom los ntawm cardboard.

Dosage daim ntawv

Qhov muag poob qis 0.3%

1 ml ntawm kev daws

cov tshuaj nquag - ciprofloxacin hydrochloride (hais txog ciprofloxacin) - 3 mg,

tus zam: benzalkonium chloride - 0.10 mg, disodium ededate (disodium ntsev ntawm ethylenediaminetetraacetic acid, Trilon B), mannitol (mannitol), sodium acetate trihydrate (sodium acetic acid 3-aqueous), glacial acetic acid, dej rau kev txhaj tshuaj.

Cov tshuaj pleev tau me ntsis daj lossis daj ntsuab

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Thaum ua ntawv thov saum toj no, ciprofloxacin nkag mus rau hauv cov ntaub so ntswg ntawm lub qhov muag. Nws nkag mus rau sab hauv lub qhov muag thiab chav sab nraub qaum ntawm lub qhov muag, tshwj xeeb tshaj yog thaum npog npog ntawm lub ntsej muag puas tsuaj. Nrog rau kev mob puas, ua rau cov tshuaj ciprofloxacin ua rau nws zoo tiv thaiv cov kab mob ua rau mob pob txha.

Tom qab kev tsim tawm ib zaug, kev saib xyuas ntawm ciprofloxacin hauv ya raws ntawm chav anterior ntawm lub qhov muag tau mus txog tom qab 10 feeb thiab yog 100 μg / ml. Qhov siab tshaj plaws ntawm Cmax hauv cov dej noo ntawm chav tsev anterior tom qab 1 h yog 190 μg / ml. Tom qab 2 teev, qhov kev cia siab ntawm cov tshuaj pib tsawg zuj zus, thaum nws cov tshuaj tua kab mob hauv cov nqaij ntawm lub qhov muag ntev txog 6 teev, nyob rau hauv qhov chaw noo ntawm chav tsev anterior - txog 4 teev.

Tom qab instillation, systemic nqus ntawm cov tshuaj yog tau. Nrog rau kev tso npe ntawm cov tshuaj pleev qhov muag ntawm ciprofloxacin 4 zaug / hnub hauv ob lub qhov muag rau 7 hnub, qhov nruab nrab ntawm ciprofloxacin hauv cov ntshav plasma tsawg dua 2-2.5 ng / ml, qhov siab tshaj yog tsawg dua 5 ng / ml. Thaum ua ntawv thov rau sab saum toj, T1 / 2 los ntawm ntshav yog li 4-5 teev. Cov tshuaj raug tso tawm los ntawm lub raum tsis hloov - nce txog li 50%, thiab hauv daim ntawv ntawm cov tshuaj metabolites - txog li 10%, los ntawm txoj hnyuv - thaj tsam li 15%. Qee cov tshuaj tawm hauv niam cov kua mis.

Cov Tshuaj Hauv Tshuaj

Tus neeg sawv cev dav dav-antimicrobial tus sawv cev los ntawm pawg fluoroquinolones (ib pawg ntawm monofluoroquinolones) rau kev siv tshuaj pleev hauv ophthalmology.

Txhawb cov kab mob DNA gyrase (topoisomerases II thiab IV, lub luag haujlwm ntawm cov txheej txheem ntawm supercoiling ntawm chromosomal DNA nyob ib ncig ntawm nuclear RNA, uas tsim nyog rau nyeem cov ntaub ntawv keeb kwm), cuam tshuam DNA synthesis, kab mob loj hlob thiab faib, ua rau muaj kev hloov pauv morphological (suav nrog cov xovtooj ntawm tes thiab daim nyias nyias) thiab kev tuag sai sai ntawm ib tus kab mob cell.

Nws ua cov kab mob ntawm cov kab mob gram-tsis zoo thaum lub sijhawm so thiab faib (vim nws cuam tshuam tsis tsuas yog DNA gyrase, tab sis kuj ua rau lysis ntawm phab ntsa cell), thiab cov kab mob gram-zoo tsuas yog nyob rau lub sijhawm faib. Nce permeability ntawm cov kab mob cell cell.

Tsis tshua muaj tshuaj lom rau macroorganism hlwb tau piav qhia los ntawm qhov tsis muaj DNA gyrase hauv lawv. Thaum noj ciprofloxacin, tsis muaj kev sib txig ntawm kev tawm tsam cov tshuaj tua kab mob uas tsis koom nrog pawg ntawm gyrase inhibitors, uas ua rau nws muaj txiaj ntsig zoo tiv thaiv cov kab mob uas tiv taus aminoglycosides, penicillins, cephalosporins, tetracyclines thiab ntau lwm yam tshuaj tua kab mob.

Rhiab rau ciprofloxacin: cov kab mob gram-negative aerobic: enterobacteria (Escherichia coli, Salmonella spp., Shigella spp., Citrobacter spp., Klebsiella spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia marcescens, Hafnia alvei, Edwardsiella tarda, Providencia spp., Morganella m. Yersinia spp.), Lwm yam gram cov kab mob tsis zoo (Haemophilus spp., Pseudomonas aeruginosa, Moraxella catarrhalis, Aeromonas spp., Pasteurella multocida, Plesiomonas shigelloides, Campylobacter jejuni, Neisseria spp.), qee cov kab mob intracellular - Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Corynebacterium diphtheriae,

Cov kab mob aerobic Gram-positive: Dab Tsi Staphylococcus spp.(Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus), Cov kab mob Streptococcus spp. (Cov kab mob Streptococcus pyogenes, Cov kab mob Streptococcus agalactiae).

Feem ntau cov tshuaj methicillin-resistant staphylococci kuj tiv taus ciprofloxacin.

Hnov Kab mob ntsws Streptococcus pneumoniae, Enterococcus faecalis, Mycobacterium avium (nyob rau hauv intracellularly) - muaj pes tsawg (siab ntau yog qhov yuav tsum tau tsub lawv).

Siv tshuaj tiv thaiv zoo: Bacteroides fragilis, Pseudomonas cepacia, Pseudomonas maltophilia, Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides. Kev tsis muaj txiaj ntsig tawm tsam Treponema pallidum.

Kev thev rau ciprofloxacin nthuav tawm qeeb heev, vim tias, ntawm ib sab tes, tom qab qhov kev ua ntawm ciprofloxacin muaj kev xyaum tsis muaj microorganisms, thiab ntawm txhais tes, cov kab mob hlwb tsis muaj cov enzymes uas inactivate nws. Cov tshuaj yog qaug tshuaj lom tsawg.

Kev ntsuas rau siv

Kab mob sib kis thiab mob qhov muag los ntawm cov kab mob me me nkag siab rau cov tshuaj:

- mob sib xyaw ua ke thiab hnoos qeev

- kab mob rau cov pob txha mos

- Kev kis mob rau qhov muag tom qab raug mob lossis lub cev txawv teb chaws

Kev tiv thaiv thiab kho mob sib kis mob hauv kev raug mob ntawm lub qhov muag thiab nws cov lus txuas ntxiv (suav nrog tom qab tshem tawm ntawm lub cev txawv teb ntawm lub qhov muag, pom pob txha, tom qab kis tau tshuaj lom neeg lossis lub cev txhais tau tias) thiab thaum ua haujlwm ntawm lub pob muag (ua ntej thiab tom qab tiv thaiv kev tiv thaiv hauv kev kho mob ophthalmic).

Txoj kev ntawm daim ntawv thovthiab txhaj koob tshuaj

Hauv zos 1-2 ncos hauv hnab looj tes sib txuas ntawm lub qhov muag cuam tshuam. Qhov ntau zaus ntawm instillations nyob ntawm qhov loj ntawm cov txheej txheem inflammatory.

Thaum muaj mob sib khuav mus rau mob hnyav pes tsawg, 1-2 tee tso rau hauv hnab looj tes sib txuas ntawm lub qhov muag cuam tshuam (lossis ob lub qhov muag) txhua 4 teev, thiab hauv kev kis mob hnyav, 2 ncos txhua teev. Tom qab kev txhim kho, qhov koob tshuaj thiab ntau zaus ntawm instillations txo.

Hauv cov kab mob sib xyaw ua ke, yooj yim, scaly thiab ulcerative blepharitis - 4-8 zaug / hnub, nyob ntawm seb qhov hnyav ntawm cov txheej txheem inflammatory.

Nrog keratitis - 1 poob tsawg kawg 6 zaug / hnub.

Nrog kev puas tsuaj rau lub pob kws mob los ntawm Pseudomonas aeruginosa, 1 poob tsawg kawg ntawm 8-12 zaug / hnub.

Nrog rau kev mob uveitis ua ntej, cov tshuaj raug xaj 1 poob 8-12 zaug / hnub. Hauv cov mob dacryocystitis thiab mob canaliculitis - 1 poob 6-12 zaug / hnub, nyob rau hauv ntev - 4-8 zaug / hnub.

Thaum muaj mob rau cov pob kiav txhab: nyob rau thawj hnub - txhua 15 feeb rau 6 teev, tom qab ntawd 1 poob txhua 30 feeb thaum lub sijhawm so, thib ob hnub - 1 poob txhua teev thaum lub sijhawm sawv, los ntawm 3 mus rau 14 hnub - 1 poob txhua 4 teev hauv lub sijhawm so.

Txog kev tiv thaiv kev kis mob thib ob nrog kev raug mob ntawm lub qhov muag thiab nws qhov cuam tshuam - 1 poob 4-8 zaug / hnub rau 1-2 lub lis piam. Txog kev tiv thaiv cov mob voos tom qab kev phais mob nrog perforation ntawm lub pob muag - 1 poob 4-6 zaug / hnub thoob plaws lub sijhawm postoperative.

Lub sijhawm siv. Lub sijhawm kho yog nyob ntawm tus mob hnyav, kev kho mob thiab qhov tshwm sim ntawm kev tshawb fawb bacteriological.

Sab sij huam

- kev fab tshuaj tsis haum, mob me me thiab mob hyperemia, xeev siab

- Kev hnov ​​qhov txawv ntawm lub cev nyob rau hauv lub qhov muag

- tsw phem hauv qhov ncauj tam sim ntawd tom qab kev tsim kho

- txo hauv qhov pom tseeb tseeb

- qhov pom ntawm lub ntsej muag dawb crystalline precipitate hauv cov neeg mob uas mob caj dab

infiltration spotting lossis corneal

Cov tshuaj sib cuam tshuam

Kws tshuaj sib cuam tshuam: kev daws teeb meem ciprofloxacin tsis sib haum nrog tshuaj daws teeb meem muaj pH qhov tseem ceeb ntawm 3-4, uas lub cev lossis tshuaj tsis ruaj khov.

Nrog kev sib xyaw ua ke nrog lwm cov tshuaj tua kab mob, ib qho kev sib txuam synergistic feem ntau pom (cov tshuaj tua kab mob beta-lactam, aminoglycosides, clindamycin, metronidazole).

Cov lus qhia tshwj xeeb

Nrog saib xyuas: cov tshuaj yog tawm rau cov neeg mob uas mob hlwb, cov kab mob cerebrovascular, mob vwm los mob.

Txoj kev hais daws nyob rau hauv daim ntawv ntawm lub qhov muag tsis yog rau kev txhaj tshuaj hauv qhov muag.

Cov tshuaj tsis tuaj yeem siv tshuaj subconjunctival lossis ncaj qha rau chav sab xub ntiag ntawm qhov muag.

Thaum siv lwm cov tshuaj ophthalmic, lub sijhawm nruab nrab ntawm lawv kev tswj hwm yuav tsum yog tsawg kawg 5 feeb.

Yog tias, tom qab thov cov tee, qhov mob hyperemia txuas ntxiv lossis nce ntxiv ntev, tom qab ntawd koj yuav tsum tsis txhob siv cov tshuaj thiab sab laj nrog kws kho mob.

Ciprofloxacin-AKOS lub qhov muag tso tawm muaj cov tshuaj benzalkonium chloride uas muaj kev tiv thaiv, uas tuaj yeem ua rau lub qhov muag tsis pom kev thiab ua kom cov tawv muag muag tsis pom kev. Yog li, ua ntej siv cov tshuaj Ciprofloxacin-AKOS, tus neeg mob yuav tsum tshem cov iav ntsiab muag thiab muab lawv tso rau tsuas yog 15 feeb tom qab kev txhim kho.

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tsheb lossis cov phom sij phom sij

Cov neeg mob uas tsis pom kev zoo yog ploj ib ntus tom qab daim ntawv thov tsis pom zoo kom tsav lub tsheb lossis ua haujlwm nrog cov tshuab tsis muaj tshuab, cov tshuab lossis lwm yam khoom siv tsis zoo uas xav kom pom lub ntsej muag tam sim tom qab kev txhim kho cov tshuaj.

Daim ntawv tso tawm thiab ntim khoom

Qhov muag poob qis 0.3%.

5 ml hauv lub raj mis rau qhov muag pom kev nrog lub hau tsis sib luag thiab lub hau ntswj taub hau ua cov yas.

5 ml hauv polymer dropper fwj nrog lub hau ntswj taub hau thiab hau duav. Ib lub vial ua ke nrog cov lus qhia rau kev siv tshuaj kho mob hauv lub xeev thiab lus Lavxias yog muab tso rau hauv pob ntawv los qhia

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Ciprofloxacin-AKOS zoo li kev daws teeb meem meej nrog lub zas daj lossis ntsuab. Cov tshuaj muaj nyob rau hauv 5 ml ntim, txhua tus twg muaj tee.

Kev npaj muaj cov tshuaj nram qab no:

• ciprofloxacin hydrochloride - cov khoom tseem ceeb, 3 mg hauv 1 ml ntawm kev daws,
• anhydrous lossis 3-aqueous sodium acetate, acetic acid, mannitol, thiab lwm yam (ntxiv cov tshuaj tiv thaiv).

Qhov muag nchuav yog cov tshuaj tua kab mob-fluoroquinolones, cov tshuaj tua kab mob. Txhua lub vial nrog cov tshuaj yeeb tshuaj tso rau hauv lub thawv me me, txuas nrog cov lus qhia nrog cov cai ntawm kev siv.

Cov Yuav Tsum Tau Ua

Cov lus qhia rau daim ntawv qhia siv: cov tshuaj yog contraindicated nyob rau hauv muaj cov kis ntawm daim ntawv keratitis, fungal kev puas tsuaj rau lub qhov muag qauv. Txoj kev daws teeb meem yuav tsum tsis txhob siv los ntawm cov neeg uas muaj qhov tsis haum siab rau nws cov khoom siv.

Nrog kev siab tshaj plaws, tee yog tshuaj rau cov neeg mob uas muaj kev cuam tshuam xws li cerebral arteriosclerosis, convulsions, thiab ntshav khiav tsis xwm yeem hauv lub hlwb.

Tsuas tshuaj thiab tswj hwm

Cov twj yog txhaj rau hauv qhov qis txuas ntawm lub qhov muag. Cov tshuaj yog siv raws li cov lus pom hauv qab no:

1. Rau mob me lossis maj mam kis - 1-2 ncau nrog 4-teev so.
2. Nrog tus kab mob sib kis, 2 ncos txhua teev.

Kev noj cov tshuaj thiab qhov ntau zaus ntawm kev tswj hwm txo qis vim tias cov tsos mob qis zuj zus. Lub sijhawm rau kev kho yog teem los ntawm tus kws kho mob ib leeg zuj zus. Qhov nruab nrab, kev kho mob kav ntev li 1-2 lub lis piam.

Kev siv cov tee thaum cev xeeb tub thiab lactation

Txawm hais tias qhov muaj feem cuam tshuam los ntawm qhov muag dauv tau yooj yim nkag rau hauv qhov tsis haum xeeb thiab nkag rau hauv niam mis, yog tias xav tau kev pab sai sai, cov tshuaj yuav tau muab rau cov neeg cev xeeb tub lossis tus neeg mob mis. Kev siv ntawm txoj kev daws teeb meem nyob rau theem ntawm kev siv tes taw thiab kev pub mis niam yog tsuas yog ua rau tom qab ua tib zoo saib xyuas txhua yam tshwm sim thiab lawv cais tawm

Sab sij huam

Cov kev mob tshwm sim thaum tsim Ciprofloxacin-AKOS feem ntau tshwm sim los ntawm cov kev hloov hauv zos:

• khaus
• hlawv
• mob me
• txuas hyperemia,
• puffiness ntawm daim tawv muag,
• lacrimation
• keratitis
• keratopathy
• tsim ntawm me ntsis rau ntawm lub qhov muag,
• lub siab raug rau lub teeb,
• qhov xav tau ntawm qhov muaj nyob rau hauv lub qhov muag ntawm ib yam khoom txawv teb chaws.

Tam sim ntawd tom qab instillation, qhov tsis zoo tom qab lub qhov ncauj yuav tshwm sim, kev cuam tshuam ib ntus hauv kev ua haujlwm. Ntawm cov kab mob tsis huv hauv cov neeg mob uas tau txais kev kho mob nrog fluoroquinolone, xeev siab no tau sau tseg.

Yog tias qhov mob sib xyaw hyperemia txhawj xeeb tas li ntawm cov keeb kwm yav dhau los ntawm kev siv lub qhov muag, kev siv tshuaj yuav tsum nres thiab sab laj nrog koj tus kws kho mob.

Cov khoom tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Ciprofloxacin-Akos qhov muag pom kev yog tsim nyob rau hauv daim ntawv ntawm kev daws teeb meem ntawm lub teeb ntsuab-daj lossis daj.

Ib qho milliliter muaj peb milligrams ntawm ciprofloxacin (hauv daim ntawv ntawm hydrochloride). Cov tshuaj yeeb dej caw nram qab no ua cov tshuaj pabcuam: disodium ntsev ntawm ethylenediaminetetraacetic acid, dej d / i, mannitol lossis mannitol, benzalkonium chloride, glacial acetic acid, sodium acetate, peb-dej lossis anhydrous.

Daim ntawv tso tawm yog tsib milliliter polyethylene dropper hwj hauv cov thawv ntawv los qhia.

Cov Tshuaj Muaj Nta

Raws li cov lus qhia, Ciprofloxacin-Akos yog cov tshuaj tua kab mob, tshuaj fluoroquinolone derivative. Nws ua haujlwm bactericidal. Nws inhibits cov kab mob DNA gyrase (topoisomerases IV thiab II, uas yog lub luag haujlwm rau kev tshwm sim ntawm cov chromosomal supercoiling ze nuclear RNA, qhov no yog tsim nyog rau nyeem cov ntaub ntawv muaj keeb kwm), cuam tshuam DNA synthesis, kab mob faib thiab kev loj hlob, thiab ua rau muaj kev hloov morphological (nrog rau cov qog thiab cell phab ntsa) thiab nrawm rhuav tshem cov kab mob ntawm tes.

Nws bactericidal tawm tsam gram-tsis zoo kab mob tshwm sim thaum faib thiab dormancy (txij li nws cuam tshuam tsis tsuas DNA gyrase, tab sis kuj provokes lysis ntawm phab ntsa xov tooj), gram-zoo microorganisms - tsuas yog nyob rau hauv tus txheej txheem ntawm kev faib.

Qhov muaj tshuaj lom tsawg dua rau cov roj ntsha macroorganism tuaj yeem piav qhia los ntawm qhov tsis muaj DNA gyrase hauv lawv.

Nyob rau tib lub sijhawm, tawm tsam keeb kwm ntawm ciprofloxacin, cov khoom lag luam sib xyaw ua ke ntawm kev tawm tsam lwm cov tshuaj tua kab mob uas tsis yog gyrase inhibitors tsis tshwm sim, uas ua rau cov tshuaj siv tau zoo tiv thaiv cov kab mob uas tiv taus, piv txwv li, rau tetracyclines, cephalosporins, penicillins, aminoglycosides thiab lwm yam tshuaj tua kab mob.

Feem coob ntawm staphylococci uas tiv taus methicillin tiv taus ciprofloxacin. Qhov tsis kam ntawm cov kab mob sib kis pib qeeb heev, txij li ntawm ib sab tes, yuav luag tsis muaj cov kab mob nyob ntev tom qab tus ciprofloxacin, thiab ntawm qhov tod tes, tsis muaj cov enzymes hauv cov kab mob hlwb uas inactivate nws.

Kev taw qhia thiab contraindications

"Ciprofloxacin-Akos" yog siv rau:

• subacute thiab mob pob txha caj qaum,
• tom qab-thiab preoperative prophylaxis ntawm ophthalmic phais mob sib kis,
• blepharoconjunctivitis, blepharitis,
• kis mob ntawm cov plab hnyuv siab raum ntawm lub zeem muag tom qab nkag mus ntawm cov khoom txawv teb chaws lossis raug mob,
• keratoconjunctivitis, keratitis,
• meibomite
• mob dacryocystitis ntev
• lub qhov txhab ua mob rau lub qhov txhab ntawm lub cev.

• mob viral keratitis,
• nrog rau tus kheej rhiab rau cov khoom muaj pes tsawg leeg,
• cov me nyuam qis dua ib xyoos.

Cov lus qhia phau ntawv

"Ciprofloxacin-Akos" yog siv rau hauv zos, los ntawm kev khawb lawv rau hauv lub hnab ntim khoom sib txuas. Yog tias tus neeg mob tau mob qhov muag ntawm qhov mob me thiab mob hnyav, ib lossis ob tee yuav tsum nkag rau hauv qhov muag cuam tshuam txhua plaub teev. Yog hais tias tus kab mob yog mob heev, ces instillation yog nqa tawm txhua ob teev. Kev siv ntau zaus yog txo nrog qhov mob hloov kho. Txoj kev kho mob kav ntev li ntawm ib mus rau ob lub lis piam.

Nrog ib tug kab mob rwj

Kev siv "Ciprofloxacin-Akos" thaum muaj kab mob rau hauv lub cev: thawj hnub - tso tawm los ntawm txhua lub hlis ib teev rau rau 6 teev, tom qab ntawd txhua ib nrab teev poob los ntawm kev poob txog thaum pw tsaug zog thaum hmo ntuj, nyob rau hnub ob - poob ntawm poob los ntawm sawv ntxov mus rau yav tsaus ntuj nrog ib nrab ntawm ib teev, s nyob rau hnub peb ntawm plaub-plaub - txhua plaub teev nyob rau hauv lub qhov muag poob los ntawm poob. Yog tias qhov mob txhab tsis zoo, txoj kev kho mob tuaj yeem txuas ntxiv.

Nws yog ib qho tsim nyog yuav tsum kaw lub raj mis tom qab siv txhua zaus. Nws yog txwv tsis pub kov lub qhov muag nrog lub pob qhov taub.

Cov Cai Siv Tshuaj So

Lavxias Federation, 640008, Kurgan, Txoj Cai Lij Choj, 7.

tel / fax (3522) 48-16-89

Daim Ntawv Tso Npe Sau Npe

Synthesis OJSC, Lavxias Federation

Chaw nyob ntawm lub koom haum uas lees txais kev thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo nyob hauv thaj chaw ntawm lub koom pheej ntawm Kazakhstan thiab muaj lub luag haujlwm rau kev soj ntsuam tom qab kev saib xyuas kev nyab xeeb tshuaj hauv thaj chaw ntawm koom pheej ntawm Kazakhstan

Deсalog LLP, 050050, Koom pheej ntawm Kazakhstan,

Pharmacological kev txiav txim

Tus neeg sawv cev dav dav-antimicrobial tus sawv cev los ntawm pawg fluoroquinolones (ib pawg ntawm monofluoroquinolones) rau kev siv tshuaj pleev hauv ophthalmology. Nws rhuav tshem cov kab mob DNA gyrase (topoisomerases II thiab IV, lub luag haujlwm rau supercoiling ntawm chromosomal DNA nyob ib ncig ntawm nuclear RG, uas tsim nyog rau kev nyeem cov ntaub ntawv keeb kwm), cuam tshuam DNA synthesis, kab mob loj hlob thiab faib, thiab ua rau muaj kev hloov morphological (suav nrog cov xovtooj ntawm tes thiab daim nyias nyias) thiab kev tuag sai sai ntawm ib tus kab mob cell.

Nws ua cov kab mob ntawm cov kab mob gram-tsis zoo thaum lub sijhawm so thiab faib (vim nws cuam tshuam tsis tsuas yog DNA gyrase, tab sis kuj ua rau lysis ntawm phab ntsa cell), thiab cov kab mob gram-zoo tsuas yog nyob rau lub sijhawm faib. Nce permeability ntawm cov kab mob cell cell.

Thaum noj ciprofloxacin, tsis muaj kev sib txig ntawm kev tawm tsam cov tshuaj tua kab mob uas tsis koom nrog pawg ntawm gyrase inhibitors, uas ua rau nws muaj txiaj ntsig zoo tiv thaiv cov kab mob uas tiv taus aminoglycosides, penicillins, cephalosporins, tetracyclines thiab ntau lwm yam tshuaj tua kab mob.

Ciprofloxacin muaj invitro kev ua ub no tiv thaiv ntau hom kab mob gram-zoo thiab gram-tsis zoo. Cov kab mob ua haujlwm ntawm ciprofloxacin tshwm sim los ntawm kev cuam tshuam rau enzyme DNA gyrase, uas yog qhov tsim nyog rau kev ua ke ntawm DNA ntawm cov kab mob me me. Nws tau pom tias ciprofloxacin muaj cov txiaj ntsig ua ib qho invitro tiv thaiv cov kab mob feem ntau ntawm cov kab mob hauv qab no:

Gram-zoo:

• Staphylococcus aureus (suav nrog cov kab mob methicillin-rhiab thiab methicillin-tiv thaiv kab mob), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Viridans pab pawg).

Nyiaj Gram-negative:

• Haemophilus influenzae, Pseudomonas aeruginosa, Serratia marcescens.

Hauv kev tshawb fawb hauv vitro tau pom tias ciprofloxacin nquag tawm tsam feem ntau ntawm cov kab mob hauv qab no, txawm hais tias qhov tseem ceeb ntawm cov ntaub ntawv no tseem tsis tau txiav txim siab:

Gram-zoo:

• Enterococcusfaecalis (ntau hom kab mob tsuas yog mob pesnrab), Staphylococcushaemolyticus, Staphylococccushominis, Staphylococcussaprophytics, Staphylococcuspyogenes.

Nyiaj Gram-negative:

• Acinetobacter calcoaceticus subsp. anitratus, Aeromonas caviae, Aeromonas hydrophila, Brucella melitensis, Campylobacter coli, Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Edwardsiella tarda, Enterobacter aerogenes, Enterobacter cloacae, Escherichophella coliella Coliella Moraxella (Branhamella) catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Salmonella fibrero, Shigella fibrene , Yersinia enterocolitica.

Lwm yam kab mob me me:

• Tus mob chlamydia trachomatis (tsuas yog mob tau txaus) thiab Mycobacterium tuberculosis (tsuas yog mob tau hauj sim).

Feem ntau ntawm cov kab mob Pseudomonas cepacia thiab qee hom kab mob Pseudomonas maltophilia yuav tiv taus ciprofloxacin, zoo li feem ntau cov kab mob tsis muaj zog, suav nrog Bacteroides fragilis thiab Clostridium difficile.

Hauv cov tshuaj tiv thaiv vitro ciprofloxacin feem ntau yuav maj mam loj hlob zuj zus tuaj (kev hloov pauv ntawm kev sib tshooj).

Kev noj tshuaj ntxiv

Cov koob tshuaj pom zoo rau kev kho mob rau cov pob txha caj dab yog raws li nram no:

• ob lub tee hauv qhov mob qhov muag txhua 15 feeb rau thawj 6 teev, thiab tom qab ntawd ob tee hauv qhov mob qhov muag txhua 30 feeb hauv lub sijhawm tseem tshuav ntawm thawj hnub. On thib ob hnub, instill ob tee nyob rau hauv lub qhov muag mob txhua txhua teev. On thib peb hnub thiab mus txog 14 hnub, hno ob tee mus rau hauv qhov muag mob txhua plaub teev. Yog tias 14 hnub tom qab kev kho mob, qhov rov qab kho tus pob txha tseem tsis tshwm sim, kev kho mob tuaj yeem txuas ntxiv.

Kev pom zoo txog kev kho mob rau kab mob pob txha:

• ib lossis ob tee rau hauv hnab ntawv / hnab looj tes ua ke txhua ob teev nyob rau thawj hnub. Tom qab ntawd tsib hnub tom ntej, ib lossis ob tee txhua plaub teev.

Lub sijhawm kho mob ntev tshaj plaws rau ib qho ntawm kev kuaj pom yog 21 hnub.

Yeeb tshuaj sib cuam tshuam

Tsis muaj cov kev tshawb fawb tshwj xeeb txog kev cuam tshuam ntawm ciprofloxacin nrog lub qhov muag nrog rau lwm cov tshuaj. Txawm li cas los xij, qhov kev siv quab yuam ntawm qee cov quinolones ua rau muaj kev nce ntxiv ntawm theophylline concentration hauv ntshav, muaj kev cuam tshuam ntawm cov metabolism ntawm caffeine, thiab qhov nce ntawm cov txiaj ntsig ntawm qhov ncauj anticoagulants, warfarin thiab nws cov neeg siv. Ib qho kev hloov zuj zus hauv cov ntshiab si creatinine kuj tau sau tseg yog tias tus neeg mob tau noj cyclosporine tib lub sijhawm.

Yog tias kev siv lwm yam tshuaj ophthalmic yog npaj siab, lawv txoj kev siv yuav tsum tau faib ua lub sijhawm los ntawm 15-feeb so.

Cov tshuaj noj uas muaj qhov tsim kev pheej hmoo rau ncua sijhawm QT luv:

Ciprofloxacin, zoo li lwm yam fluoroquinolones, yuav tsum tau siv nrog ceev faj hauv cov neeg mob tau txais tshuaj uas muaj kev paub txog kev pheej hmoo ntev rau QT ntu (piv txwv, chav kawm IA thiab III tshuaj thuv rov qab, tricyclic antidepressants, macrolides, antipsychotics).

Hu rau lo ntsiab muag

Nws tsis raug nquahu los hnav cov iav lo ntsiab muag thaum lub sijhawm kho cov tshuaj. Yog tias siv lo ntsiab muag tawv, tom qab ntawd koj yuav tsum tau tshem lawv tawm ua ntej txheej txheem thiab muab tso dua 15-20 feeb tom qab kev tswj hwm tshuaj.

Qhov cuam tshuam rau kev muaj peev xwm ntawm cov neeg mob los tswj cov txheej txheem thiab tsav tsheb: cov neeg uas tau poob lawv qhov pom tseeb ntawm lub zeem muag tom qab siv Ciprofloxacin-Akos tsis raug tso cai ua haujlwm nrog cov tshuab loj, khoom siv lossis tshuab, lossis tsav lub tsheb, vim tias kev pom tseeb ntawm lub zeem muag xav tau tam sim tom qab cov txheej txheem.

Cia rau cov neeg mob thiab txee lub neej

Cov tshuaj tua kab mob yuav tsum tau muab cia rau hauv qhov chaw tiv thaiv los ntawm lub teeb, raug rau qhov kub ntawm +15 txog +25 ° C. Cov tshuaj yuav tsum tsis txhob khov. Kev nkag mus rau kev siv tshuaj rau cov menyuam yaus thiab tsiaj nyob hauv tsev yuav tsum tsis suav nrog.

Lub txee lub neej ntawm kev daws teeb meem ophthalmic hauv lub vial kaw yog 2 xyoos. Tom qab lub thawv ntim nrog cov tshuaj tau qhib, nws cov ntsiab lus yuav tsum tau siv rau nws lub hom phiaj rau 28 hnub.

Txhawm rau hloov cov khoom qub, cov lus hauv qab no thov:

• Athenoxine.
• Betaciprol.
• Vero-Ciprofloxacin.
• Ciprinol.
• Microflox.
• Quintor.
• Oftocipro.
• Nircip.

Cov khoom lag luam tau sau yog sib txuam nrog cov kev daws teeb meem, muaj qhov sib txuam, kev kho thiab cov cim taw qhia rau kev siv. Cov tshuaj zoo sib xws kuj muaj nyob rau hauv daim ntawv ntawm cov tshuaj pleev qhov muag thiab tau tsim los ua instillations.

Ciprofloxacin-AKOS yog tshuaj tua kab mob uas tsis muaj txiaj ntsig zoo uas pab tiv thaiv ntau yam mob ntawm qhov muag. Cov tshuaj muaj tus nqi pheej yig, muaj txij li 23-36 rubles. Nws tau muag hauv khw muag tshuaj nrog cov tshuaj noj. Ua ntej siv cov cuab yeej no, nws yog qhov yuav tsum tau soj ntsuam ophthalmic thiab tau txais tshuaj ntawm kws kho mob.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, 0.25 g 2-3 zaug hauv ib hnub, nrog muaj cov mob hnyav - 0.5-0.75 g 2-3 zaug ib hnub.

Yog tias muaj mob txeeb zig - 0.25-0,5 g 2 zaug ib hnub, tau txais kev kho mob - 7-10 hnub.

Nrog tus kab mob gonorrhea tsis yooj yim - 0.25-0.5 g ib zaug, nrog kev sib xyaw gonococcal muaj chlamydial thiab mycoplasma - 0.75 g txhua 12 teev rau 7-10 hnub.

Nrog chancroid - 0.5 g 2 zaug ib hnub rau ob peb hnub.

Nrog meningococcal carriage hauv nasopharynx - ib zaug, 0.5 lossis 0.75 g.

Hauv kev mob lub cev ntev ntawm Salmonella, los ntawm qhov ncauj, 0.25 g 4 zaug, kev kho mob mus txog 4 lub lis piam. Yog tias tsim nyog, ntau npaum li cas ntxiv tau ntxiv rau 0.5 g 3 zaug ib hnub.

Nrog mob ntsws, osteomyelitis - sab hauv, 0.75 g 2 zaug ib hnub. Lub sijhawm kho mob ntawm osteomyelitis tuaj yeem mus txog li 2 hli.

Txog kev mob plab hnyuv tshwm sim los ntawm Staphylococcus aureus, 0.75 g txhua 12 teev rau 7-28 hnub.

Kev kho yuav tsum txuas ntxiv tsawg kawg yog 3 hnub tom qab ua haujlwm ntawm lub cev kub los yog ploj ntawm cov tsos mob hauv chaw kho mob.

Hauv qhov ntsuas pom ntawm glomerular (CC 31-60 ml / min / 1,73 sq.m lossis cov ntshav creatinine concentration ntawm 1,4 txog 1,9 mg / 100 ml), qhov siab tshaj plaws niaj hnub noj yog 1 g .Thaum tus nqi glomerular pom qis dua 30 ml / min / 1,73 sq. m los yog cov ntshav creatinine siab tshaj 2 mg / 100 ml; qhov siab tshaj plaws niaj hnub noj tshuaj - 0.5 g.

Yog tias tus neeg mob tau mob hemodialysis lossis peritoneal lim ntshav - 0.25-0,5 g / hnub, tab sis cov tshuaj yuav tsum tau noj tom qab kev kho mob hemodialysis.

Hauv kev kis mob hnyav (piv txwv li, kev mob tshwm sim ntawm lub plab, mob ntawm lub plab, pob txha thiab pob qij txha) los ntawm Pseudomonas lossis staphylococci, mob ntsws txhawm rau los ntawm Streptococcus pneumoniae, thiab mob chlamydial ntawm lub genitourinary tus mob, qhov koob tshuaj yuav tsum tau nce rau 0.75 g txhua 12 teev.

Cov ntsiav tshuaj yuav tsum nqos tag nrho nrog cov kua hauv qab me me tom qab noj mov. Thaum noj cov tshuaj rau ntawm lub plab khoob, cov tshuaj nquag yuav nqus tau sai dua.

Kev tso dej nrog kua: qhov kev tso tawm ntev yog 30 feeb ntawm koob tshuaj 0.2 g thiab 60 feeb ntawm koob tshuaj 0.4 g. Kev daws teeb meem, npaj siv, tuaj yeem ua ke nrog 0.9% NaCl daws, Lub suab lub tshuaj thiab Ringer-lactate, 5 thiab 10% kev daws dextrose, 10% kev daws teeb meem fructose, nrog rau cov tshuaj muaj 5% dextrose tov nrog 0.225-0.45% NaCl tov.

Nrog rau cov mob tso zis yooj yim, txo cov hlab ntsws ua pa, ib koob tsuas yog 0.2 g, nrog cov mob hnyav ntawm cov mob txeeb zig sab saud, nrog rau kis mob hnyav (nrog rau mob ntsws, mob txha), ib koob tshuaj yog 0.4 g. Yog tias tsim nyog, / Hauv kev kho mob tshwj xeeb tshaj yog mob hnyav, tuag taus lossis rov kis dua los ntawm Pseudomonas, staphylococci lossis Streptococcus pneumoniae, cov koob tshuaj yuav raug nce rau 0.4 g nrog ntau zaus ntawm kev tswj kom txog 3 zaug hauv ib hnub. Lub sijhawm kho mob osteomyelitis tuaj yeem ncav cuag ntev txog 2 hlis.

Nrog kev mob plab ntev ntawm Salmonella - 0.2 g 2 zaug hauv ib hnub, muaj kev kho mob - txog 4 lub lis piam. Yog tias tsim nyog, ntau npaum li cas ntxiv tau ntxiv rau 0.5 g 3 zaug ib hnub.

Hauv kev mob gonorrhea mob - 0.1 g ib zaug.

Txog kev tiv thaiv kev kis kab mob thaum tab tom phais mob - 0.2-0.4 g rau 0.5-1 teev ua ntej phais, nrog sijhawm ntev tshaj 4 teev, rov siv tshuaj rau tib lub koob tshuaj.

Lub sijhawm nruab nrab ntawm kev kho mob: 1 hnub - nrog tus mob tsis haum thiab mob cystitis, ntev txog 7 hnub - nrog rau mob ntawm lub raum, mob txeeb zig thiab mob plab, thoob plaws lub sijhawm ntawm neutropenic theem - hauv cov neeg mob uas lub cev tsis muaj zog tiv thaiv, tab sis tsis ntau tshaj 2 hlis - nrog osteomyelitis thiab 7-14 hnub - nrog rau lwm yam kev kis mob. Nrog rau tus mob streptococcal vim qhov txaus ntshai ntawm qhov mob lig, nrog rau mob chlamydial, kev kho mob yuav tsum nyob ntev li 10 hnub. Hauv cov neeg mob uas siv tshuaj tiv thaiv kab mob, kev kho mob yog nqa tawm thaum lub sijhawm tag nrho ntawm neutropenia.

Kev kho yuav tsum tau nqa tawm tsawg kawg yog 3 hnub tom qab ua kom lub cev tsis sov lossis ploj ntawm cov tsos mob hauv chaw kho mob.

Ntawm qhov ntsuas pom ntawm glomerular (CC 31-60 ml / min / 1,73 sq. M lossis cov ntshav creatinine concentration ntawm 1.4 txog 1.9 mg / 100 ml), qhov siab tshaj plaws niaj hnub noj yog 0.8 g.

Ntawm tus nqi glomerular pom (CC hauv qab 30 ml / min / 1.73 sq. M lossis cov ntshav creatinine siab tshaj 2 mg / 100 ml), qhov siab tshaj plaws niaj hnub noj yog 0.4 g.

Rau cov neeg mob laus, cov koob tshuaj tau raug txo los ntawm 30%.

Nrog rau tus mob peritonitis, nws raug tso cai siv kev tswjhwm intraperitoneal ntawm kev saib xyuas infusion nyob rau hauv ib koob ntawm 50 mg 4 zaug hauv ib hnub rau 1 liter ntawm dialysate.

Tom qab kev tswj hwm iv, kev kho mob tuaj yeem txuas ntxiv ntawm qhov ncauj.

Kev sib txuam

Vim tias txo qis hauv cov haujlwm ntawm microsomal oxidation kev ua haujlwm hauv hepatocytes, nws nce qhov siab thiab ntev ntev T1 / 2 ntawm theophylline (thiab lwm yam xanthines, piv txwv li caffeine), tshuaj tiv thaiv kab mob hypoglycemic, thiab qhov tsis ncaj ntawm anticoagulants, thiab pab txo qis prothrombin index.

Thaum ua ke nrog lwm cov tshuaj tua kab mob (beta-lactam tshuaj tua kab mob, aminoglycosides, clindamycin, metronidazole), synergism feem ntau pom, tuaj yeem siv ua ke nrog azlocillin thiab ceftazidime rau kev kis mob los ntawm Pseudomonas spp., Nrog meslocillin, azlocillin lactam thiab lwm yam. cov tshuaj tua kab mob - rau kev tiv thaiv kab mob streptococcal, nrog isoxazolepenicillins thiab vancomycin - rau cov mob staphylococcal, nrog metronidazole thiab clindamycin - rau mob anaerobic.

Txhim kho cov txiaj ntsig nephrotoxic ntawm cyclosporine, ib qho kev nce ntawm serum creatinine tau sau tseg, hauv cov neeg mob zoo li no, kev tswj hwm ntawm qhov ntsuas no 2 zaug hauv ib lub lim tiam yog tsim nyog.

Nyob rau tib lub sijhawm, nws ua kom muaj txiaj ntsig zoo ntawm cov nqi tiv thaiv tsis tau.

Kev tswj hwm hauv qhov ncauj ua ke nrog Fe-muaj cov tshuaj, cov tshuaj ua tsis tau zoo thiab cov tshuaj tiv thaiv antacid uas muaj Mg2 +, Ca2 + thiab Al3 + ua rau txo qis ntawm kev nqus ntawm ciprofloxacin, yog li nws yuav tsum tau siv tshuaj 1-2 teev ua ntej lossis 4 teev tom qab noj cov tshuaj saum toj no.

NSAIDs (tsis suav nrog ASA) nce kev pheej hmoo ntawm qaug dab peg.

Didanosine txo qis kev nqus ntawm ciprofloxacin vim yog kev tsim cov nyom nrog nws muaj Al3 + thiab Mg2 + muaj nyob hauv didanosine.

Metoclopramide nrawm kev nqus, uas ua rau txo qis hauv lub sijhawm nws ncav cuag Cmax.

Qhov kev sib koom tes ntawm kev siv tshuaj uricosuric ua rau kev txo qis ntawm kev tshem tawm (nce txog 50%) thiab nce ntxiv ntawm cov ntshav plasma concentration ntawm ciprofloxacin.

Txoj kev lis ntshav yog tshuaj tsis haum nrog txhua txoj kev lis ntshav thiab tshuaj uas lub cev thiab tshuaj tsis zoo nyob rau hauv ib puag ncig acidic (pH ntawm ciprofloxacin infusion daws yog 3.9-4.5). Tsis txhob sib tov rau kev tswj hwm iv nrog kev daws teeb meem muaj pH ntawm ntau dua 7.

Cov lus nug, lus teb, tshuaj xyuas ntawm tshuaj Ciprofloxacin-AKOS

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.