Trazenta: tshuaj xyuas cov neeg mob ntshav qab zib, muaj pes tsawg leeg, cim thiab contraindications

Rau lub xyoo xya, ib qho tshuaj zoo rau kev kho mob ntshav qab zib tau tshwm sim rau ntawm kev ua lag luam, kev siv uas tsis dhau qhov kev mob nkeeg ntawm cov kab mob hlab plawv, ob lub raum thiab mob siab, cov ntshav qab zib tau hais. "Trazhenta", uas yog ua raws li lub blocker ntawm enzyme dipeptidyl peptidase-4 linagliptin, hais txog cov neeg ua hauj lwm hypoclycemic. Cov nyhuv pharmacological ntawm cov tshuaj yog tswj los txo cov synthesis ntawm cov tshuaj hormonal glucagon, ntxiv rau kev tsim cov tshuaj insulin ntau ntxiv. Cov hom tshuaj no tam sim no tau lees paub tias yog ib qho muaj txiaj ntsig zoo tshaj plaws rau kev tswj hwm tus mob phom sij - hom mob ntshav qab zib thib ob.

Mob ntshav qab zib yog dab tsi?

Qhov no yog cov kab mob ntawm cov tshuaj endocrine, vim qhov kev txiav txim siab ntawm cov piam thaj hauv tus neeg cov ntshav nce ntxiv, txij li lub cev poob lub peev xwm los nqus cov insulin. Qhov tshwm sim ntawm qhov kev mob no yog qhov loj heev - cov txheej txheem hauv lub cev tsis ua tiav, cov hlab ntsha, kabmob thiab cov tshuab muaj cuam tshuam. Ib qho txaus ntshai tshaj plaws thiab insidious yog ntshav qab zib ntawm hom thib ob. Tus kab mob no yog hu ua kev hem thawj rau tib neeg.

Ntawm qhov ua rau cov tib neeg kev tuag nyob rau ob xyoo dhau los, nws tau los ua ntej. Qhov tseem ceeb tshaj plaws hauv kev txhim kho tus kab mob yog suav tias yog kev ua tsis tiav ntawm kev tiv thaiv ntawm lub cev. Cov tshuaj tua kab mob yog tsim nyob rau hauv lub cev uas muaj kev puas tsuaj rau hlwb pancreatic. Raws li qhov tshwm sim, cov piam thaj hauv qhov ntau hauv cov ntshav dawb hauv lub cev, muaj cov txiaj ntsig tsis zoo rau cov kabmob thiab cov kab ke. Raws li qhov tsis txaus ntseeg, lub cev siv cov rog yog cov khoom siv lub zog, uas ua rau kom muaj ntau ntxiv ntawm lub cev ketone, uas yog cov tshuaj lom. Raws li qhov txiaj ntsig ntawm qhov no, txhua hom kev zom zaub mov uas tshwm sim hauv lub cev tau cuam tshuam.

Yog li, nws yog qhov tshwj xeeb tshaj yog thaum nrhiav kev mob siab rau xaiv txoj kev kho kom zoo thiab siv cov tshuaj muaj txiaj ntsig zoo, piv txwv li, "Trazhentu", tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob txog cov uas tuaj yeem pom hauv qab no. Kev phom sij ntawm cov ntshav qab zib yog tias ntev ntev los nws yuav tsis muab kev kuaj mob, thiab kuaj pom cov ntshav qab zib muaj txiaj ntsig ntau yog tshawb pom los ntawm kev muaj mob rau lwm qhov kev soj ntsuam tom ntej.

Qhov tshwm sim ntawm ntshav qab zib

Cov kws tshawb fawb thoob ntiaj teb niaj hnub ua qhov kev tshawb fawb uas niaj hnub ua kom pom cov qauv tshiab los tsim cov tshuaj uas tuaj yeem kov yeej cov kev mob uas txaus ntshai. Hauv xyoo 2012, ib lub tshuaj tshwj xeeb tau sau npe hauv peb lub teb chaws, uas qhov tseeb tsis ua rau muaj kev mob tshwm sim thiab muaj kev zam zoo rau cov neeg mob. Tsis tas li ntawd, nws raug tso cai rau lees txais cov tib neeg uas lub raum thiab hepatic tsis muaj txiaj ntsig - raws li tau sau rau hauv kev txheeb xyuas "Trazhent".

Kev phom sij loj yog cov mob ntshav qab zib hauv qab no:

txo nyob rau hauv kev pom tseeb mus txog rau nws ua tiav poob,
txoj haujlwm tsis ua haujlwm ntawm lub raum,
vascular thiab kab mob plawv - myocardial infarction, atherosclerosis, ischemic mob plawv,
ko taw cov kab mob - cov txheej txheem purulent-necrotic, mob txhab txhab,
qhov pom ntawm qhov mob txhab ntawm daim tawv nqaij,
fungal tawv txhab,
neuropathy, uas yog qhov pom los ntawm kev chua leeg, tev thiab ib qho txo qis ntawm qhov tsis hnov mob ntawm daim tawv nqaij,
coma
ua txhaum ntawm cov haujlwm ntawm cov qis qis.

"Trazhenta": lus piav qhia, muaj pes tsawg leeg

Ib qho tshuaj yog tsim hauv cov ntawv ntim tshuaj. Muab cov tshuaj biconvex puag ncig nrog cov npoo beveled muaj lub plhaub liab lub teeb. Ntawm ib sab muaj lub cim ntawm cov chaw tsim khoom, nthuav tawm hauv daim ntawv ntawm kev txua, ntawm sab tod - cov ntawv cim alphanumeric D5.

Cov tshuaj phiv yog linagliptin, vim tias nws cov txiaj ntsig zoo rau ib koob tshuaj, tsib milligrams txaus. Qhov kev tivthaiv no, nce insulin ntau lawm, txo glucagon synthesis. Cov nyhuv tshwm sim ib puas thiab nees nkaum feeb tom qab kev tswj hwm - nws yog tom qab lub sijhawm no uas nws qhov siab tshaj nyob rau hauv cov ntshav tau pom. Excipients tsim nyog rau kev tsim cov ntsiav tshuaj:

magnesium stearate,
pregelatinized thiab pob kws hmoov txhuv nplej siab,
mannitol yog ib tug diuretic,
copovidone yog ib qho tshuaj.

Lub plhaub muaj cov hypromellose, talc, xim liab (hlau oxide), macrogol, titanium dioxide.

Cov yam ntxwv ntawm cov tshuaj

Raws li kws kho mob, "Trazhenta" hauv kev kho mob tau ua pov thawj tau txais txiaj ntsig hauv kev kho mob thib ob hom ntshav qab zib mellitus hauv tsib caug lub tebchaws hauv ntiaj teb, suav nrog Russia. Cov kev tshawb fawb tau ua nyob rau nees nkaum-ob lub teb chaws nyob rau hauv uas ntau txhiab tus neeg mob uas muaj hom mob ntshav qab zib thib ob koom nrog kev sim tshuaj.

Vim tias qhov tseeb tias cov tshuaj tawm hauv lub cev los ntawm tus neeg dhau los ntawm kev mob plab, thiab tsis yog los ntawm lub raum, nrog kev tsis zoo hauv lawv txoj haujlwm, kev hloov kho tshuaj tsis tas yuav tsum. Qhov no yog ib qho ntawm qhov sib txawv tseem ceeb ntawm Trazenti thiab lwm cov tshuaj tiv thaiv kab mob kev nkeeg. Cov kev ua tau zoo hauv qab no yog cov hauv qab no: tus neeg mob tsis muaj ntshav qab zib thaum noj cov ntsiav tshuaj, ob qho tag nrho nrog Metformin, thiab nrog monotherapy.

Hais txog lub chaw tsim khoom ntawm cov tshuaj

Kev tsim cov tshuaj Trazhenta, tshuaj xyuas cov uas muaj kev ywj pheej, yog nqa los ntawm ob lub tuam txhab tshuaj.

"Eli Lilly" - rau 85 xyoo yog ib qho ntawm lub ntiaj teb cov thawj coj hauv kev ua haujlwm ntawm cov kev txiav txim siab tshiab uas txhawb rau cov neeg mob uas muaj mob ntshav qab zib. Lub tuam txhab txuas ntxiv nthuav dav nws cov ntau yam siv cov kev tshawb fawb zaum kawg.
"Beringer Ingelheim" - ua nws cov keeb kwm txij li xyoo 1885. Nws koom nrog kev tshawb fawb, kev tsim kho, kev tsim khoom, nrog rau kev muag tshuaj. Lub tuam txhab no yog ib qho ntawm nees nkaum lub ntiaj teb cov thawj coj hauv kev lag luam kws tshuaj.

Thaum pib ntawm xyoo 2011, ob lub tuam txhab tau kos npe rau kev pom zoo rau kev koom tes hauv kev tiv thaiv mob ntshav qab zib, ua tsaug uas kev txhim kho tseem ceeb tau txais hauv kev kho kab mob insidious. Lub hom phiaj ntawm kev sib txuam nrog yog kawm txog kev sib txuam ntawm plaub yam tshuaj tshiab uas yog ib feem ntawm cov tshuaj tsim los tshem tawm cov tsos mob ntawm tus kabmob.

Kev ntsuas rau siv

Raws li kev tshuaj xyuas thiab cov lus qhia rau kev siv, "Trazhenta" pom zoo rau kev siv rau kev kho mob thib ob hom mob ntshav qab zib mellitus ob leeg nrog kev kho mob monotherapy thiab koom tes nrog lwm cov ntsiav tshuaj hypoglycemic tus neeg sawv cev, nrog rau tshuaj insulin npaj. Hauv thawj kis, nws yog kws kho rau:

contraindications kom noj Metformin los yog lub raum puas,
kev tswj tsis tau glycemic tiv thaiv keeb kwm ntawm kev kawm lub cev thiab kev noj zaub mov tshwj xeeb.

Nrog rau qhov tsis muaj txiaj ntsig ntawm kev kho mob monotherapy nrog cov tshuaj hauv qab no, nrog rau kev pab ntawm kev noj haus thiab kev tawm dag zog, kev kho mob nyuaj yog qhia.

Nrog sulfonylurea derivatives, Metformin, thiazolidinedione.
Nrog cov tshuaj insulin lossis Metformin, pioglitazone, sulfonylureas thiab cov tshuaj insulin.
Nrog Metformin thiab sulfonylurea derivatives.

Cov Yuav Tsum Muaj

Raws li kev txheeb xyuas thiab cov lus qhia, “txwv tsis pub noj” yog txwv tsis pub noj thaum tus me nyuam tseem tos, nrog rau lub sijhawm pub mis. Hauv cov kev tshawb fawb preclinical, nws tau pom tias cov tshuaj ua kom nquag plias (linagliptin) thiab nws cov khoom metabolites kis mus rau niam mis. Yog li, nws yog tsis yooj yim sua kom cais tawm qhov tsis zoo rau ntawm tus me nyuam hauv plab thiab cov khoom noj tawg uas nyob ntawm kev pub mis niam. Yog tias nws tsis tuaj yeem tshem tawm cov tshuaj thiab hloov nws nrog cov zoo sib xws, cov kws kho mob hais kom hloov ntawm ntuj mus rau kev pub mis.

Kev siv cov ntsiav tshuaj yog contraindicated hauv qab no:

hnub nyoog rau kaum yim,
mob ketoacidosis,
ntshav qab zib hom 1
tus kheej tsis kam rau cov khoom xyaw uas ua rau "Trazenti".

Hauv kev tshuaj xyuas ntawm cov kws kho mob, ntxiv rau hauv cov lus qhia rau kev siv cov tshuaj no, muaj cov ntaub ntawv hais tias nws yuav tsum tau siv nrog kev ceev faj rau cov neeg muaj hnub nyoog yim caum xyoo thaum noj nws nrog insulin thiab (lossis) sulfonylurea-based tshuaj. Cov kev tshawb fawb ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav lub tshuab thiab tsheb tsis tau ua. Txawm li cas los xij, vim tias qhov tshwm sim uas yuav tshwm sim ntawm kev txo qis, tshwj xeeb tshaj yog thaum tau txais kev kho mob sib xyaw, yuav tsum ceev faj. Yog kuaj pom muaj kab mob pancreatitis, cov tshuaj yuav tsum raug txiav mus ntxiv. Hauv qhov no, tus kws kho mob yuav xaiv txoj kev kho tshiab.

Cov lus qhia tshwj xeeb

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias rau kev kho mob ketoacidosis ntawm type 1 ntshav qab zib mellitus, Trazenti yog qhov txwv tsis pub. Hauv kev kuaj mob ntshav qab zib, xws li cov lus ceeb toom yog qhov ntau. Ntxiv rau, nws tau sau tseg tias qhov kev pheej hmoo ntawm pathologies ntawm cov hlab plawv tsis nce ntxiv. Cov neeg uas muaj lub siab tsis ua haujlwm ntawm lub siab thiab lub raum tuaj yeem coj cov tshuaj kom tsis muaj teeb meem li niaj zaus, nws txoj kev kho kom haum yog tsis xav tau.

Hauv pawg hnub nyoog txij li xya caum mus rau yim xyoo, kev siv ntawm linagliptin qhia tau tias tshwm sim zoo. Tau pom qhov txo qis:

glycosylated hemoglobin,
ntshav muaj piam thaj ntau ntawm ib plab khoob.

Kev noj tshuaj los ntawm cov neeg uas tau hla yim yim xyoo lub neej yav dhau los yuav tsum tau nqa nrog kev ceev faj heev, vim qhov kev paub hauv chav kho mob nrog pab pawg no muaj tsawg heev.

Qhov xwm txheej ntawm tus mob ntshav qab zib tsawg tsawg heev thaum noj ib qho "Trazenta". Tus neeg mob tshuaj xyuas kuj lees paub qhov tseeb no. Tsis tas li ntawd, hauv lawv cov lus pom, lawv nco ntsoov tias hauv kev sib xyaw nrog lwm cov tshuaj rau ntshav qab zib, txoj kev loj hlob ntawm glycemia yog qhov tsis lees paub. Hauv cov xwm txheej no, yog tias tsim nyog, tus kws kho mob tuaj yeem txo qhov koob tshuaj insulin lossis sulfonylurea derivatives. Txais tos "Trazhenty" tsis nce rau kev pheej hmoo ntawm lub plawv lossis hlab ntsha tawg, uas yog qhov tseem ceeb thaum noj nws thaum hnub nyoog laus dua.

Kev phiv tshuaj

Ntau cov tshuaj siv los kho ntshav qab zib tuaj yeem ua rau lub hauv paus pathological uas nyob rau theem ntawm cov piam thaj hauv cov ntshav poob qis, uas ua rau muaj kev phom sij rau tus neeg. "Trazhenta", hauv kev txheeb xyuas cov uas nws tau hais tias kev noj nws tsis ua rau cov ntshav qog ntshav, yog kev zam rau txoj cai. Qhov no yog suav tias yog qhov muaj txiaj ntsig tseem ceeb dua lwm cov chav kawm ntawm cov kab mob hypoglycemic. Ntawm qhov tshwm sim tsis zoo uas tuaj yeem tshwm sim thaum lub sijhawm kho "Trazentoy", cov hauv qab no:

pancreatitis
hnoos haum
nasopharyngitis,
kev tiv thaiv tsis haum
nce rau hauv ntshav amylase,
ua pob
thiab lwm tus.

Thaum muaj ib qho kev noj ntau dhau, cov kev coj ua niaj hnub qhia tau hais txog kev tshem tawm ib qho tshuaj uas tsis tuaj yeem hauv lub plab thiab cov kev kho mob.

"Trazhenta": tshuaj xyuas cov neeg mob ntshav qab zib thiab cov kws kho mob

Qhov ua tau zoo ntawm cov tshuaj tau rov qab tau lees paub dua los ntawm kev kho mob thiab cov kev tshawb fawb thoob ntiaj teb. Endocrinologist nyob rau hauv lawv cov lus pom zoo kom siv nws hauv kev kho mob sib txuas los yog ua thawj txoj kev kho. Yog tias tus neeg muaj lub siab tsis zoo rau cov ntshav qab zib, uas ua rau cov khoom noj tsis zoo thiab kev siv lub cev, nws raug nquahu kom muab "Trazent" hloov ntawm sulfonylurea derivatives. Nws tsis yog ib txwm ua tau los soj ntsuam qhov ua tau zoo ntawm cov tshuaj yog tias nws raug coj los ua ke nrog kev kho, tab sis feem ntau cov txiaj ntsig yog qhov zoo, uas tseem sau tseg los ntawm cov neeg mob. Muaj kev txheeb xyuas txog cov tshuaj "Trazhenta" thaum nws tau pom zoo rau kev rog thiab insulin tsis kam.

Qhov zoo ntawm cov tshuaj tiv thaiv kab mob tsis zoo yog tias lawv tsis pab txhawb kom yuag, tsis txhob txhawm rau txhim kho hypoglycemia, thiab kuj tsis ua teeb meem rau lub raum. Trazhenta tau nce kev nyab xeeb, uas yog qhov tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib. Yog li ntawd, muaj qhov ncaj ncees ntawm kev soj ntsuam zoo txog cov cuab yeej no tshwj xeeb. Ntawm cov minuses nco ntsoov tus nqi siab thiab tus kheej tsis kam.

Cov tshuaj analog "Trazhenty"

Kev tshuaj xyuas rov los ntawm cov neeg mob noj cov tshuaj no feem ntau zoo. Txawm li cas los xij, rau qee cov tib neeg, vim muaj qhov tsis txaus siab lossis tsis ua haujlwm, cov kws kho mob pom zoo kom siv cov tshuaj zoo sib xws. Cov no suav nrog:

"Sitagliptin", "Januvia" - cov neeg mob noj cov tshuaj no ntxiv rau kev tawm dag zog, kev noj zaub mov kom zoo dua qub, los txhim kho kev tswj hwm ntawm lub xeev glycemic, ntxiv rau, cov tshuaj siv rau hauv kev kho ua ke,
"Alogliptin", "Vipidia" - feem ntau cov tshuaj no raug pom zoo nyob rau hauv qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo, kev tawm dag zog thiab kho mob monotherapy,
"Saksagliptin" - yog tsim nyob rau hauv cov npe lag luam "Ongliza" rau kev kho hom mob ntshav qab zib thib ob, nws yog siv ob qho tib si hauv monotherapy thiab nrog lwm cov ntsiav tshuaj thiab tshuaj inulin.

Kev xaiv ntawm ib qho tshuaj tiv thaiv kab mob yog ua los ntawm kev kho tus mob endocrinologist nkaus xwb, kev hloov pauv tshuaj ywj siab yog txwv tsis pub muaj.

Cov neeg mob raum tsis ua haujlwm

"Zoo heev tshuaj" - xws li lo lus feem ntau pib rave xyuas txog "Trazhent". Qhov kev txhawj xeeb loj heev thaum noj tshuaj tiv thaiv kab mob siab yeej ib txwm muaj kev paub los ntawm cov tib neeg uas muaj lub raum tsis ua haujlwm ntawm lub raum, tshwj xeeb tshaj yog cov uas muaj kab mob hemodialysis. Nrog kev tawm tsam ntawm cov tshuaj no hauv lub khw muag tshuaj network, cov neeg mob raum pathologies qhuas nws, txawm tias tus nqi siab.

Vim yog qhov tshwj xeeb ntawm kev txiav txim tshuaj, cov txiaj ntsig ntawm cov piam thaj tau txo qis thaum noj cov tshuaj tsuas yog ib zaug ib hnub ntawm kev kho mob ntawm tsib milligrams. Thiab nws tsis muaj teeb meem lub sijhawm ntawm kev noj cov ntsiav tshuaj. Cov tshuaj yog nqus sai sai tom qab nkag mus rau hauv lub zom zaub mov, qhov siab tshaj plaws tau pom tom qab ib thiab ib nrab lossis ob teev tom qab kev tswj hwm. Nws tawm hauv cov quav, uas yog, ob lub raum thiab lub siab tsis koom nrog txoj kev no.

Xaus

Raws li kev kuaj xyuas ntshav qab zib, Trazhent tuaj yeem siv sijhawm twg los tau yooj yim, tsis hais noj zaub mov thiab tsuas pub noj ib hnub ib zaug, uas suav tias yog ib qho loj ntxiv. Qhov tsuas yog qhov yuav tsum nco ntsoov: koj tsis tuaj yeem noj tshuaj rau ob zaug hauv ib hnub. Hauv kev ua ke nrog txoj kev kho, qhov noj ntau npaum "Trazhenty" tsis hloov. Tsis tas li ntawd, nws txoj kev kho tsis tas yuav tsum muaj teeb meem nrog lub raum. Cov ntsiav tshuaj tau zoo zam, qhov ua tsis taus yog qhov tsis tshua muaj. "Trazhenta", kev txheeb xyuas ntawm cov uas txaus siab heev, muaj cov khoom tshwj xeeb nrog kev ua haujlwm siab. Ntawm tsis muaj qhov tseem ceeb me me yog qhov tseeb tias cov tshuaj muaj nyob hauv cov npe tshuaj uas raug rho hauv cov khw muag tshuaj rau cov tshuaj dawb.

Trazhenta - muaj pes tsawg leeg thiab daim ntawv noj tshuaj

Cov chaw tsim khoom, BOEHRINGER INGELHEIM PHARMA (Lub Tebchaws Yelemees) thiab BOEHRINGER INGELHEIM ROXANE (USA), tso tawm cov tshuaj nyob rau hauv daim ntawv ntawm convex round liab ntsiav tshuaj. Ntawm ib sab yog lub cim engraved ntawm lub chaw tsim khoom lag luam uas tiv thaiv tshuaj los ntawm fakes, nyob rau lwm qhov - cim "D5".

Lawv txhua tus muaj 5 mg ntawm cov nquag muaj cov khoom xyaw linagliptin thiab ntau yam xws li hmoov txhuv nplej siab, zas xim, hypromellose, magnesium stearate, copovidone, macrogol.

Txhua lub ntsej muag txhuas blaig pob 7 lossis 10 ntsiav tshuaj ntawm cov tshuaj Trazhenta, yees duab uas tuaj yeem pom hauv tshooj no. Hauv lub thawv lawv tuaj yeem yog tus lej sib txawv - los ntawm ob txog yim daim phiaj. Yog tias lub blister muaj 10 lub hlwb nrog cov ntsiav tshuaj, tom qab ntawd hauv lub npov yuav muaj 3 daim phiaj ntawd.

Kws Tshuaj

Cov peev xwm ntawm cov tshuaj tau muaj kev vam meej yog vim muaj qhov thaiv ntawm kev ua ntawm dipeptidyl peptidase (DPP-4). Qhov enzyme no yog kev puas tsuaj

ntawm cov tshuaj hormones HIP thiab GLP-1, uas yog lub luag haujlwm tseem ceeb hauv kev saib xyuas cov ntshav qab zib kom sib npaug. Lub incretins txhim kho insulin ntau lawm, pab tswj glycemia, thiab inhibit qhov tsis zais ntawm glucagon. Lawv cov haujlwm yog luv-nyob ntev; tom qab, HIP thiab GLP-1 zom cov enzymes. Trazhenta thim rov qab cuam tshuam nrog DPP-4, qhov no tso cai rau koj los tswj kev noj qab haus huv ntawm incretins thiab txawm tias nce qib lawv.

Lub tshuab ntawm cawv ntawm Trazhenty yog zoo ib yam li cov qauv ntawm kev ua haujlwm ntawm lwm yam tshuaj tiv thaiv - Januvius, Galvus, Ongliza. HIP thiab GLP-1 yog tsim thaum khoom noj khoom haus nkag mus rau hauv lub cev. Qhov ua tau zoo ntawm cov tshuaj tsis cuam tshuam nrog kev tsa ntawm lawv cov ntau lawm, cov tshuaj tsuas yog nce lub sijhawm ntawm lawv kis. Vim tias cov yam ntxwv zoo li no, Trazhenta, zoo li lwm yam nce ntxiv, tsis cuam tshuam kev txhim kho ntawm hypoglycemia thiab qhov no yog qhov muaj txiaj ntsig tseem ceeb dua lwm cov chav kawm ntawm cov tshuaj hypoglycemic.

Yog tias cov piam thaj hauv cov ntshav qab zib tsis txaus, ntau zog, kev pab ntau ntxiv pab txhawm rau tsim cov tshuaj endogenous los ntawm β-hlwb. Qhov tshuaj hormones GLP-1, uas muaj cov npe tseem ceeb ntau dua piv rau GUI, txwv cov khoom ntawm glucagon hauv cov qog hlwb. Tag nrho cov txheej txheem no pab kom ruaj khov kho glycemia nyob rau hauv qib kom zoo - kom txo qis glycosylated hemoglobin, yoo mov qab zib thiab ntshav qab zib tom qab kev qoj ib ce nrog ob-teev sib nrug. Hauv kev kho ua ke nrog metformin thiab sulfonylurea kev npaj, glycemic tsis txhim kho yam tsis muaj qhov hnyav hnyav.

Cov Tshuaj Pharmacokinetics

Tom qab nkag mus rau hauv lub plab zom mov, cov tshuaj tau nrawm nrawm, Cmax muaj kev pom tom qab ib teev thiab ib nrab. Qhov kev txiav txim siab poob qis ua ob ntu.

Kev siv cov ntsiav tshuaj nrog zaub mov noj lossis cais ntawm tus kws kho mob ntawm cov tshuaj tsis muaj kev cuam tshuam. Lub bioavailability ntawm cov tshuaj yog li 30%. Qhov feem pua me me yog metabolized, 5% ua tawm los ntawm lub raum, 85% nrog quav ua quav. Ib qho kab ke ntawm lub raum tsis tas yuav tshem tshuaj lossis hloov koob tshuaj. Cov yam ntxwv ntawm pharmacokinetics thaum yau tseem tsis tau kawm.

Yog leej twg noj tshuaj rau

Kev siv tshuaj yog tus kws kho mob thawj zaug los sis ua ke nrog lwm cov tshuaj txo suab thaj.

Kev Kho Mob Kho Mob. Yog tias tus mob ntshav qab zib tsis kam ua cov tshuaj ntawm cov chav kawm ntawm bigudins xws li metformin (piv txwv li, nrog lub raum pathologies lossis tus neeg tsis haum rau nws cov khoom siv), thiab kev hloov kho hauv lub neej tsis coj cov txiaj ntsig xav tau.
Ob-tivthaiv Circuit Court. Trazent yog tshuaj ua ke nrog sulfonylurea npaj, metformin, thiazolidinediones. Yog tias tus neeg mob tau tshuaj insulin, incretinomimetic tuaj yeem pab ntxiv nws.
Peb-tivthaiv xaiv. Yog tias qhov kev kho mob dhau los ua tsis tau zoo, Trazhenta ua ke nrog cov tshuaj insulin thiab qee yam tshuaj tiv thaiv kab mob uas muaj kev sib txawv ntawm cov tshuaj.

Uas tsis tau muab rau Trazhent

Linagliptin yog contraindicated rau cov pawg ntawm cov ntshav qab zib:

Yam 1 ntshav qab zib
Ketoacidosis provoked los ntawm ntshav qab zib,
Cev xeeb tub thiab lactating
Cov menyuam yaus thiab cov hluas
Kev ua haujlwm tsis haum xeeb rau cov khoom xyaw ntawm cov mis.

Yam tsis tau xav txog

Ntawm keeb kwm ntawm kev noj cov tshuaj linagliptin, cov kev mob tshwm sim tuaj yeem tsim:

Nasopharyngitis (ib tug mob kis)
Kev hnoos hnoos
Kev ua haujlwm tsis zoo
Kev mob caj dab
Kev nce hauv triglycerol (thaum ua ke nrog sulfonylurea chav tshuaj),
Nce LDL ntau dua (nrog rau kev tswj hwm ntawm pioglitazone),
Lub cev hnyav
Cov tsos mob hypoglycemic (tawm tsam keeb kwm yav dhau los ntawm ob - thiab peb-txheej kev kho).

Qhov ntau zaus thiab cov lej ntawm cov nyom uas tshwm sim tom qab siv Trazhenta zoo ib yam li cov lej ntawm cov nyom tsis zoo tom qab siv cov placebo. Feem ntau, cov kev mob tshwm sim nrog triple ua txoj kev kho ntawm Trazhenta nrog metformin thiab sulfonylurea derivatives.

Cov tshuaj yuav ua rau muaj kev sib koom ua ke, nws yog ib qho tseem ceeb uas yuav tsum xav txog qhov no thaum tsav tsheb thiab cov txheej txheem nyuaj.

Noj ntau dhau

Cov neeg koom tau muab 120 ntsiav tshuaj (600 mg) ib zaug. Ib qho kev noj qab haus huv ib zaug tsis muaj kev cuam tshuam txog kev noj qab haus huv ntawm cov neeg ua haujlwm pab dawb los ntawm cov pab pawg noj qab haus huv. Ntawm cov neeg mob ntshav qab zib, kev haus dej cawv ntau dhau tsis tau sau tseg los ntawm kev kho mob. Thiab tsis tas li ntawd, yog tias muaj xwm txheej los yog txhob txwm siv ntau lub koob tshuaj tib lub sijhawm, tus neeg mob yuav tsum yaug lub plab thiab cov hnyuv kom tshem tawm ib feem ntawm cov tshuaj noj, muab sorbents thiab lwm yam tshuaj raws li cov tsos mob, qhia tus kws kho mob.

Yuav ua li cas thiaj yuav siv cov tshuaj

Ua raws li cov lus qhia rau kev siv, kev siv tshuaj yuav tsum noj 1 ntsiav tshuaj (5 mg) peb zaug ib hnub. Yog tias cov tshuaj siv rau hauv cov kev kho mob hauv kev sib txuam nrog metformin, tom qab ntawd cov tshuaj ntawm qhov kawg yog tswj tau.

Cov neeg mob ntshav qab zib uas mob raum lossis mob siab tsis xav tau hloov kho qhov koob. Cov cai tsis txawv rau cov neeg mob hnub nyoog tiav. Hauv senile (los ntawm 80 xyoo) hnub nyoog, Trazhenta tsis yog kws kho mob vim tias tsis muaj kev kuaj mob hauv cov qeb no.

Yog tias lub sijhawm noj tshuaj tsis zoo, koj yuav tsum haus ib lub ntsiav tshuaj sai li sai tau. Nws yog tsis yooj yim sua ob npaug rau cov cai. Kev siv cov tshuaj tsis khi rau lub sijhawm noj mov.

Cawv ntawm trazhenti rau cev xeeb tub thiab lactation

Cov txiaj ntsig ntawm kev siv tshuaj los ntawm cov poj niam cev xeeb tub tsis tau luam tawm. Txog tam sim no, cov kev tshawb fawb tau tsuas yog ua rau cov tsiaj, thiab tsis muaj cov tsos mob ntawm kev muaj me nyuam muaj mob lom. Thiab tsis tau, thaum cev xeeb tub, cov poj niam tsis tau sau tshuaj siv.

Hauv kev sim coj cov tsiaj, nws pom tias cov tshuaj muaj peev xwm nkag mus rau leej niam cov kua mis ntawm tus poj niam. Yog li no, thaum lub sijhawm pub mis, pojniam tsis raug tso rau Trazhent. Yog tias lub xeev kev noj qab haus huv xav tau cov kev kho mob, tus menyuam pauv mus rau khoom noj khoom haus khoom neeg tsim.

Cov kev sim rau kev cuam tshuam ntawm cov tshuaj ntawm kev muaj peev xwm xeeb tub hauv tus menyuam tsis tau ua tiav. Cov kev sim zoo sib xws ntawm cov tsiaj tsis qhia txog kev phom sij ntawm sab no.

Yeeb tshuaj sib cuam tshuam

Kev siv ib txhij ntawm Trazhenta thiab Metformin, txawm tias cov koob tshuaj ntau dua li cov qauv, tsis ua rau muaj qhov sib txawv tseem ceeb hauv cov khw muag tshuaj ntawm cov tshuaj.

Kev siv tam sim no ntawm Pioglitazone kuj tsis hloov pauv ntawm pharmacokinetic peev ntawm ob qho tshuaj.

Cov kev kho mob nyuaj nrog Glibenclamide tsis txaus ntshai rau Trazhenta, rau tom kawg, Cmax qis me ntsis (los ntawm 14%).

Qhov tshwm sim zoo sib xws hauv kev sib cuam tshuam yog qhia los ntawm lwm cov tshuaj ntawm chav kawm sulfonylurea.

Kev sib xyaw ntawm ritonavir + linagliptin nce Cmax los ntawm 3 zaug, xws li kev hloov pauv tsis tas yuav tsum kho ntau npaum li cas.

Kev sib xyaw nrog Rifampicin provoke ib qho kev poob qis hauv Cmax Trazenti. Qee feem, cov chaw kuaj mob tau khaws cia, tab sis cov tshuaj tsis ua haujlwm 100%.

Nws tsis yog qhov txaus ntshai yuav tau sau ntawv Digoxin tib lub sijhawm uas lynagliptin: lub chaw muag tshuaj ntawm ob qho tshuaj tsis hloov.

Trazhent tsis cuam tshuam rau lub peev xwm ntawm Varfavin.

Cov kev hloov pauv me tau pom nrog txoj kev siv sib txig sib xyaw ntawm linagliptin nrog simvastatin, tab sis cov lej me me tsis cuam tshuam loj heev rau nws tus yam ntxwv.

Tawm tsam keeb kwm ntawm kev kho mob nrog Trazhenta, tshuaj tiv thaiv qhov ncauj tuaj yeem siv dawb do.

Cov lus pom zoo ntxiv

Kev siv tshuaj tsis zoo yog siv rau kev mob ntshav qab zib hom 1 thiab rau ketoacidosis, uas ua rau mob ntshav qab zib.

Qhov tshwm sim ntawm hypoglycemic qhov xwm txheej tom qab kho nrog linagliptin, siv los kho mob monotherapy, yog qhov txaus rau tus lej ntawm cov mob no nrog cov placebo.

Cov kev sim tshuaj tau pom tias qhov ntau zaus ntawm kev tshwm sim ntawm kev mob ntshav qab zib thaum siv Trezhenta hauv kev sib xyaw ua ke tsis suav nrog, vim tias qhov mob tseem ceeb tsis yog vim linagliptin, tab sis los ntawm metformin thiab tshuaj ntawm thiazolidinedione pab pawg.

Kev ceeb toom yuav tsum tau pom thaum sau ntawv ntawm Trazhenta txuam nrog sulfonylurea cov tshuaj hauv chav kawm, vim nws yog lawv uas ua rau cov ntshav qab zib tsis txaus. Hauv kev pheej hmoo siab, nws yog qhov tsim nyog yuav tau kho cov tshuaj ntau npaum li cas ntawm sulfonylurea pawg.

Linagliptin tsis cuam tshuam qhov tshwm sim ntawm kev txhim kho pathologies ntawm lub plawv thiab cov hlab ntshav.

Hauv kev kho ua ke, Trazhent yuav siv tau txawm tias muaj qhov ua rau lub raum tsis zoo ua haujlwm.

Hauv cov neeg mob ntawm cov neeg laus (ntau dua 70 xyoo), Trezenta kho tau pom tias HbA1c zoo: qhov pib glycosylated hemoglobin yog 7.8%, zaum kawg - 7.2%.

Cov tshuaj tsis ua rau muaj kev cuam tshuam txog kev mob plawv hauv lub plawv ntau dua. Thawj qhov kawg ntawm lub cev muaj pes tsawg zaus thiab lub sijhawm tshwm sim ntawm kev tuag, lub plawv nres, mob hlab ntsha tawg, mob qog ntshav siab tsis txaus uas yuav tsum tau mus pw hauv tsev kho mob, cov neeg mob ntshav qab zib uas tau noj linagliptin tsawg dua thiab tom qab tshaj cov neeg pab dawb hauv pawg tswj hwm uas tau txais cov tshuaj placebo lossis kev sib piv cov tshuaj.

Qee qhov xwm txheej, kev siv cov linagliptin ua rau muaj kev tawm tsam ntawm kev mob caj dab.

Yog tias muaj cov cim (mob hnyav hauv lub phaus mob, mob plab tsis txaus, ua kom tsis muaj zog dav dav), cov tshuaj yuav tsum nres thiab sab laj nrog koj tus kws kho mob.

Kev kawm txog kev cuam tshuam ntawm Trazhenta ntawm kev muaj peev xwm tsav tsheb thiab cov cuab yeej siv tsis yooj yim tseem tsis tau ua, tab sis vim yog muaj kev cuam tshuam tsis zoo, siv cov tshuaj yog tias tsim nyog, muaj qhov kub siab ntawm kev saib xyuas thiab cov tshuaj tiv thaiv sai nrog ceev faj.

Kev ntsuas thiab tus nqi ntawm cov tshuaj

Rau cov tshuaj Trazhenta, tus nqi yog li ntawm 1500-1800 rubles rau 30 ntsiav tshuaj nrog qhov ntau npaum ntawm 5 mg. Cov tshuaj kws kho mob muab tawm.

Cov tshuaj tawm qauv ntawm tib chav kawm ntawm DPP-4 inhibitors muaj xws li Januvia raws li synagliptin, Ongliz raws li saxagliptin thiab Galvus nrog lub vildagliptin nquag tivthaiv. Cov tshuaj no sib phim nrog ATX Qib 4 code.

Ib qho kev cuam tshuam zoo sib xws yog siv cov tshuaj Sitagliptin, Alogliptin, Saksagliptin, Vildagliptin.

Tsis muaj cov kev cai tshwj xeeb rau kev khaws cia ntawm Trazenti hauv cov lus qhia. Rau peb lub xyoo (raws li lub sijhawm tas sijhawm), cov ntsiav tshuaj yog khaws cia hauv chav kub (txog +25 degrees) hauv qhov chaw tsaus uas tsis muaj menyuam nkag mus. Cov tshuaj uas tas sij hawm tuaj yeem siv tsis tau, lawv yuav tsum muab pov tseg.

Tus mob ntshav qab zib thiab kws kho mob hais txog Trazhent

High efficiency Trazhenty nyob rau hauv ntau cov kev sib txuas ua pov thawj los ntawm cov kev tshawb fawb thoob ntiaj teb thiab kev kho mob. Endocrinologist nyiam siv linagliptin ua thawj cov tshuaj lossis hauv kev kho ua ke. Nrog ib qho kev nyiam ntawm cov ntshav qog ntshav (kev tawm dag zog lub cev, khoom noj tsis zoo), es tsis txhob sulfonylurea cov tshuaj hauv chav kawm, lawv tau muab rau Trazhent, muaj kev tshuaj xyuas txog cov tshuaj ntawm cov tshuaj rau cov tshuaj tiv thaiv insulin thiab kev rog dhau. Ntau tus neeg mob ntshav qab zib tau txais cov tshuaj ua ib feem ntawm txoj kev kho mob kom zoo, yog li nws tsis yooj yim los soj ntsuam nws cov txiaj ntsig, tab sis feem ntau, txhua tus neeg zoo siab nrog qhov tshwm sim.

DPP-4 cov tshuaj tiv thaiv kab mob, uas Trazhenta belongs, yog qhov txawv tsis yog los ntawm kev muaj peev xwm tiv thaiv kab mob, tab sis kuj los ntawm kev muaj kev nyab xeeb ntau ntxiv, vim tias lawv tsis ua rau cov nyhuv hypoglycemic, tsis pab txhawb rau qhov hnyav nce, thiab tsis txhob ua kom lub raum tsis ua haujlwm. Txog hnub no, cov hom tshuaj no suav hais tias yog ib qho muaj peev xwm tshaj plaws rau kev tswj hwm ntawm tus mob ntshav qab zib hom 2.