Yuav siv Cozaar li cas?

Cov tshuaj muaj sia yog kev thaiv kevlub txais angiotensin 2Cov. Cov tshuaj ua tiav tag nrho cov kev cuam tshuam. antiotensin, tsis hais leej twg txoj kev ntawd lub enzyme yog synthesized, lossis los ntawm qhov twg tau txais. Yeej paub tias angiotensin 2(haib dhau vasoconstrictor) yog qhov kev txhim kho tseem ceeb leeg ntshav siabCov. Ntxiv rau, cov tshuaj yeeb dej caw yam tsis ua angiotensin antagonist.

Lub chaw muaj kev xaiv koom nrog tej kev AT1 lub txaistsis muaj kev cuam tshuam cov receptors ntawm lwm tus ion raws thiab cov tshuaj hormonesCov. Losartan tsis muaj cov nyhuv ntawm kininase 2 thiab bradykininCov. Nws yog qhov tseeb tias cov tshuaj ua kom nquag plias ntawm cov tshuaj tsis yog tus ua edema.

Tom qab noj tshuaj, qhov kev sib txuam ntawm kev tsis sib haum ploj mus angiotensin 2 thiab kev zais reninkev ua si ARPnce.

Tom qab kho nrog cov tshuaj rau 6 lub lis piam, cov concentration angiotensin 2 nce 2-3 zaug ntxiv. Qhov kev cuam tshuam zoo ntawm cov receptors tshwj xeeb kuj tshwm sim, uas tag nrho ua tiav nws tus kheej twb tau 14-48 hnub tom qab pib siv tshuaj.

Nws yog qhov tseeb tias cov tshuaj muaj tsis cuam tshuam rau tej nroj tsuag n.s. thiab reflexes, qab zib concentration hauv ntshavCov. Losartan yog qhov ntau yam sib txawv ntawm cov khw muag tshuaj ACE inhibitorsnws thaiv cov teebmeem angiotensin 1 thiab 2yam tsis muaj kev cuam tshuam bradykinin(ACE inhibitors ua txoj hauv kev).

Nrog rau qhov nce hauv qhov ntau ntxiv ntawm cov tshuaj, nws cov nyhuv hypotensive nce.

Thaum ua qhov kev tshawb fawb nrog cov txiv neej noj qab haus huv, tom qab noj 100 mg ntawm yeeb tshuaj, raug rau cov ntsev qis lossis ntsev ntau cov pluas nojnrawm glomerular pom,pom feemthiab lub raum ua hauj lwm tag nrho tsis hloov. Txawm li cas los xij, nce urinary acid excretion los ntawm ob lub raum thiab cov zis urinary sodium nce ntxiv.

Cov poj niam nyob hauv lawm thiab lub sijhawm tom qab kev txom nyem los ntawm ntau ntxiv ntshav siabnrog rau kev noj tshuaj rau txhua hnub ntawm 50 mg ntawm kev muab tshuaj rau ib hlis qib PGtsis hloov.

Hauv kev sim tshuaj, lub hom phiaj ntawm uas yog txhawm rau soj ntsuam qhov tsis muaj kev noj qab nyob zoo, kev tuag thiab lub plawv tawg, rau cov neeg mob CNS los ntawm cov tshuaj txhua hnub losartan, Nws tau raug pov thawj tias cov tshuaj hauv qhov tshuaj ntawm 150 mg yog qhov ua tau zoo tshaj li 50 mg. Cov kev tshawb fawb tau ua rau 4 xyoo.

Tom qab cov ntsiav tshuaj nyob hauv Kev kho mob txoj hnyuv, qhov nquag ua haujlwm ntawm Cozaar yog qhov zoo thiab nrawm nrawm, nkag mus rau cov kab ke hauv nruab nrog thiab metabolized (14%) hauv cov ntaub so ntswg ntawm daim siab. Losartan cov ntaub ntawv nquag (carboxylated) thiab ua tsis tau zoo (N-2-tetrazole-glucuronide) metabolitesCov. Bioavailability yog li 30%. Qhov siab tshaj plaws ntawm losartan yog pom tom qab 60 feeb, nws cov khoom noj khoom haus - tom qab 3.5 teev. Pharmacokinetic cov kev ywj pheej yog tsis ywj pheej ntawm cov khoom noj.

Cov tshuaj muaj qib siab heev ntawm kev muab khi rau cov ntshav protein - txog 99%. Cov tshuaj yeeb dej caw tsis xebntshav-hlwb thaiv.

Cov tshuaj tau tawm hauv cov qauv ntawm cov tshuaj metabolites lossis hloov pauv los ntawm lub raum thiab quav, nyob rau hauv 120 feeb thiab 5-6 teev, ua ntu zus. Thaum noj 100 mg ntawm cov tshuaj rau ib hnub, nws tsis txuas rau kom khaws cia hauv lub cev.

Pharmacokinetic tsis tsis vam khom hnub nyoog. Txawm li cas los xij, hauv cov poj niam, lub plasma concentration ntawm cov khoom nquag yog 2 npaug siab dua li txiv neej.

Hauv cov neeg mob uas muaj kab mob siab (nrog mob ntsws) ntshav plasma concentration ntau dua ntau dua li cov neeg noj qab nyob zoo.

Ntawmkev tshem tawm tus kheej ntau dua 10 ml ib feeb twg, hauv cov neeg tsis hemodialysis, cov tshuaj ntsuas tsis tau sib txawv. Cov khoom tsis dhau ntawm lub sijhawm hemodialysis.

Kev ntsuas rau siv

• cov neeg kev txom nyem los ntawm leeg ntshav siab,
• los tiv thaiv ob lub raum thaum mob ntshav qab zib2 hom nrog tshuaj proteinuria,
• los txo cov kev pheej hmoo ntawm kev tsim lub plawv nres (mob hlab ntsha tawg, plawv nres) lossis tuag thaum tus neeg mob nrogsab laug ventricular hypertrophy thiab nce ntxiv HUAB TAIS,
• nrog mob plawv tsis ua hauj lwm, nrog thev tsis tau lossis tsis ua hauj lwm zoo ACE inhibitors,
• los txo cov xwm txheej ntawm txoj kev loj hlob Mob raum tsis ua hauj lwm (hauv theem davhlau ya nyob twg, yog tias yuav tsum tau hloov khoom siv lossis hemodialysis).

Cov Yuav Tsum Muaj

• ntawm ua xua ntawm nws lub Cheebtsam,
• nrog intolerance lactose,piam thaj galactose malabsorption syndromelossis nyiaj tsawg lactases,
• Cov neeg uas muaj mob rau daim siab mob hnyav
• tsis tau muaj 18 xyoo,
• txuam nrog Aliskiren,
• cev xeeb tub thiab lactating cov poj niam.

Ceev faj yuav tsum siv:

• ntawm ob sab stenosis lub raum mob ntshav lossis lub raum leeg mob stenosis (yog tias tus neeg mob muaj ib lub raum)
• mob nrog lub plawv dhia tsis zootshwj xeeb hauv kev ua ke thiab lub raum tsis ua hauj lwm,
• ntawmIschemic mob plawv lossis mob plawv dhia tsis xwm yeem,
• tom qab lub raum hloov,
• ntawm mitral lossis aortic stenosis,
• cov neeg mob nrog cerebrovascular tus kab mob, Quincke's edema, suav nrog keeb kwm ntawm
• ntawm txo Bcc.

Sab sij huam

Cov neeg mob tau nce HUAB TAIS cov tshuaj feem ntau zoo tiv thaiv. Kev phiv tshuaj yog kev hloov chaw, dhau caij nyoog, tshem tawm yeeb tshuaj tsis tas yuav.

Feem ntau cov manifested: kiv taub haudaim tawv nqaij ua pob orthostatic tshua.

• pw tsaug zog, mob taub hau, asthenia,
• palpitations, mob hauv siab, tsis muaj zog, qaug zog, peripheral edema,
• tachycardiamob hauv epigastric cheeb tsam,
• kem plabxeev siab zawv plab,
• mob leeg, mob nraub qaum,
• rhinitishnoos mob hlab ntsws, pharyngitis thiab lwm yam kab mob ntawm cov mob ua pa sab saud los ntawm kis kab mob.

Ntawm ntshav qab zib hom 2 feem ntau tsim: tsis muaj zog, kiv taub hau, hyperkalemia, arterial hypotension.

Qhov ntau zaus thiab xwm txheej ntawm cov nyom tshwm sim nyob ntawm kev siv tshuaj txhua hnub uas tus neeg mob noj. Yog li, thaum noj 150 MG ntawm Cozaar ib hnub ntau feem ntau tshwm sim: hyperkalemialub raum tsis ua hauj lwm, txo qis HUAB TAISqib nce neeg tsim tswvpoov tshuaj thiab urea hauv cov ntshav.

Hauv lub sijhawm tom qab sau npe ntawm cov tshuaj, cov kev mob tshwm sim hauv qab no tau txheeb xyuas:

• ntuav, mob siab, kab mob siab,
• thrombocytopenia, myalgia,
• mob plab thiab mob taub hau,
• anemia, arthralgia,
• txo qis libido thiab impotence,
• urticariadaim tawv liab thiab ua pob rau ntawm daim tawv nqaij, tawv ntxig rau lub teeb.

Cov lus qhia rau siv Cozaar (qauv thiab ntau npaum li cas)

Cov tshuaj tau sau tawm ntawm qhov ncauj, tsis hais noj zaub mov.

Qhov ntau npaum li cas thiab kev noj tshuaj yuav tsum yog txiav txim los ntawm tus kws kho mob koom nrog, thaum cov tshuaj tuaj yeem ua ke nrog lwm cov tshuaj rau kev mob ntshav siab.

Cov lus qhia rau siv Cozaar

Nrog rau cov ntshav siab nce ntxiv, cov tshuaj pib = 50 mg rau ib hnub.

Tom qab 21-42 hnub tom qab pib kev kho mob, cov tshuaj nce mus txog nws qhov kev ua haujlwm ntau tshaj plaws.

Yog tias tsim nyog, koob tshuaj yuav raug nce ntxiv rau 100 mg ib hnub twg.

Rau cov neeg mob muaj ntau zog HUAB TAIS nrog sab laug ventricular hypertrophy lossis ntshav qab zib hom 2 qhov kev siv tshuaj thawj zaug kuj yog = 50 mg ib hnub (tom qab ntawd nws nce rau 100 mg).

Tus neeg nrog CHF hauv thawj theem ntawm kev kho mob, koj tuaj yeem noj 12,5 mg ntawm cov tshuaj ib hnub ib zaug. Cov koob tshuaj tau nce txhua 7 hnub (25 mg, 50 mg, 100 mg thiab 150 mg) raws li tus neeg mob.

Nyob rau qis circulating cov ntshav ntim(tom qab noj tshuaj kho mob) Qhov tshuaj thawj zaug yog 25 mg rau ib hnub.

Tsis tas li, kev hloov kho tshuaj yog tsim nyog rau kab mob siab mob siab.

Noj ntau dhau

Tsis muaj pov thawj pom tias muaj neeg siv tshuaj ntau dhau. Nws tau kwv yees tias kev noj ntau ntawm cov tshuaj yuav ua rau poob qis HUAB TAISthiab tachycardia.

Raws li kev kho mob, ua cov tsos mob thiab txhawb kev kho mob. Hemodialysisua tsis tau zoo.

Kev sib txuam

Cov tshuaj tsis tuaj yeem ua ke nrog Aliskirenntawm mob ntshav qab zib lossis nrog rau lub raum tsis ua haujlwm.

Thaum muab sib xyaw xaiv COX-2 inhibitors, non-steroidal anti-inflammatory tshuaj tiv thaiv nrog Losartan cov kev ua tau zoo ntawm ob pab pawg ntawm cov tshuaj txo qis.

Kev sib xyaw ntawm cozaar nrog Spironolactone, Amiloride, Triamterenthiab lwm tus poov tshuaj-sparing diureticsua rau kom muaj protein ntau ntau ntxiv hauv cov ntshav.

Yeej paub tias Rifampicin tuaj yeem txo cov ntshav plasma concentration ntawm cov tshuaj no.

Losartan complicates txheej txheem ntawm kev tshem lithium tawm hauv lub cev.

Nrog kev kub ntxhov, cov tshuaj thiab PNVS, qhov no tuaj yeem ua tau (tshwj xeeb tshaj yog rau cov neeg laus, cov neeg mob lub cev qhuav dej) kom ua rau lub nra ntawm lub raum. Cov kev hloov pauv tau thim rov qab, feem ntau yuav ploj mus tom qab ib qho ntawm cov tshuaj raug muab tso tseg.

Cov lus qhia tshwj xeeb

Cov tshuaj tsis ua hauj lwm zoo hauv txo qis zaus uas muaj mob plawv rau cov neeg mob ntawm cov haiv neeg Negroid. Hauv qhov no, atenolol ua tau hauj lwm zoo dua. Qhov no ua rau qhov xaus ntawd ACE inhibitors thiab angiotensin antagoniststsis tshua muaj txiaj ntsig hauv cov neeg mob ntawm cov haiv neeg Negroid.

Cov tshuaj tsis pom zoo thaum coj mus kho thawj hyperaldosteronism, nws tsis txoHUAB TAIS.

Vim tias qhov tseeb ntawm qee qhov kev mob tshwm sim tuaj yeem cuam tshuam rau qhov nrawm thiab raug ntawm psychomotor cov tshuaj tiv thaiv, nws raug nquahu kom tsis txhob tsav tsheb thaum siv cov tshuaj.

Cov qauv ntawm Cozaar

Tus thawj cov tshuaj muaj ntau ntawm cov yeeb yaj kiab nrog cov pab pawg zoo sib xws ntawm cov nquag:Angizar, Cardomin-Sanovel, Giperzar, Ksartan, Lozap, Closart, Lozartin, Lorista, Losar, Presartan, Pulsar, Erinorm.

Tsis tas li ntawd analogues ntawm cov tshuaj yog: Advantan, Votum, Aprovel, Vasar, Valsacor, Vanatex, Diovan, Diocor, Irbetan, Candesar, Cantab, Kasark, Mikardis, Teveten, Firmasta, Hizart, Edarbi.

Pharmacological thaj chaw ntawm cov tshuaj Cozaar

Cov Tshuaj Hauv Tshuaj
Angiotensin II yog vasoconstrictor muaj zog, yog ib yam tshuaj lom ntawm lub cev renin-angiotensin thiab ib qho tseem ceeb tshaj plaws hauv pathophysiology ntawm kub siab. Angiotensin II khi rau AT1 receptor pom nyob rau hauv ntau cov ntaub so ntswg (piv txwv li, vascular du leeg, qog adrenal, lub raum, thiab lub siab), thiab txiav txim siab qhov teeb meem ntawm cov roj ntsha tseem ceeb, suav nrog vasoconstriction thiab aldosterone tso tawm. Angiotensin II tseem muaj kev cuam tshuam cov kev loj hlob ntawm cov leeg hlwb muaj zog. Hauv cov xwm txheej hauv vitro thiab hauv vivo losartan thiab nws cov tshuaj pharmacologically nquag metabolite - carboxylic acid (E-3174) thaiv tag nrho cov kev mob ntawm lub cev anigotensin II tsis hais qhov twg los ntawm txoj kev los yog kev coj los ua ke. Losartan xaiv zoo khi rau AT1 receptor, tsis khi los yog thaiv lwm cov tshuaj receptors thiab ion channels. Losartan tsis inhibit ACE (kininase II), ib qho enzyme uas txhawb nqa kom tawg ntawm bradykinin. Raws li qhov tshwm sim, cov teebmeem tsis cuam tshuam ncaj qha rau kev thaiv ntawm AT1 receptor (piv txwv li, qhov nce ntawm qhov cuam tshuam loj ntawm cov teebmeem ntawm bradykinin) tsis cuam tshuam nrog kev siv losartan.
Kev siv losartan tuaj yeem txo qhov kev phom sij tag nrho los ntawm cov kab mob plawv, muaj pes tsawg tus neeg mob hlab ntsha tawg thiab myocardial infarction hauv cov neeg mob ntshav siab (tawg) thiab sab laug ventricular hypertrophy, muaj cov nyhuv nephroprotective hauv cov neeg mob uas muaj ntshav qab zib II mellitus nrog proteinuria.
Cov Tshuaj Pharmacokinetics
Kev Tsis Txaus Siab
Tom qab kev tswj hwm ntawm qhov ncauj, losartan yog qhov zoo thiab yauv ua rau thawj cov kab mob metabolism nrog kev tsim cov metabolite ntawm carboxylic acid thiab lub cev tsis muaj zog. Cov kab ke ntawm qhov ncauj ntawm qhov ncauj ntawm losartan yog li 33%. Qhov nruab nrab ntawm cov tshuaj tiv thaiv ntawm losartan thiab nws cov metabolite nquag tau mus txog tom qab 1 teev thiab 3-4 teev, ua ntu zus. Kev siv tshuaj nrog cov zaub mov tsis cuam tshuam rau qhov concentration ntawm losartan hauv cov ntshav ntshav.
Kev xa Khoom
Kev khi ntawm losartan thiab nws cov metabolite nrog plasma protein, feem ntau nrog albumin, yog ntau dua 99%. Kev faib khoom ntim - 34 l. Txoj kev tshawb no pom tias losartan tsis zoo rau lub cev BBB lossis tsis nkag rau txhua qhov.
Kev Ntaus Tawm
Plasma tshem tawm rau losartan thiab nws cov nquag metabolite yog li 600 thiab 50 ml / min, feem. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite nquag yog li ntawm 74 thiab 26 ml / min, feem. Tom qab cov tshuaj noj ntawm qhov ncauj, yuav luag 4% ntawm cov koob tshuaj tau pom tias tsis hloov pauv hauv cov zis thiab txog 6% ntawm cov koob tshuaj raws li cov tshuaj metabolite. Nrog rau qhov ncauj tswj hwm ntawm losartan poov tshuaj hauv qhov siab txog 200 mg, tus kws tshuaj ntawm cov tshuaj thiab nws cov nquag metabolite yog tawm.
Tom qab lub qhov ncauj tswj hwm, cov tshuaj ntawm cov tshuaj thiab nws lub zog metabolite hauv cov ntshav ntshav tsawg zuj zus nrog qhov kawg ntawm lub neej ntawm 2 teev rau losartan thiab 6-9 teev rau lub zog metabolite. Tom qab qhov ncauj tswj hwm ntawm C14-daim ntawv loartan los ntawm lub cev, kwv yees li 35% ntawm xov tooj cua tau tshawb pom nyob hauv cov zis, 58% hauv cov quav.
Pharmacokinetics hauv cov pab pawg neeg mob tshwj xeeb
Cov neeg laus cov neeg mob
Qhov siab ntawm losartan thiab nws cov metabolite hauv cov ntshav ntshav ntawm cov neeg laus cov neeg mob ntshav siab (mob ntshav tsis txaus) tsis txawv ntawm qhov ntawd hauv cov neeg mob ntshav siab (arterial hypertension) ntawm cov hnub nyoog yau.
Tub los ntxhais
Qhov siab ntawm losartan hauv cov ntshav ntshav yog 2 npaug ntau dua rau cov neeg mob ntshav siab (poj niam tawg) poj niam. Qhov kev mob siab ntawm cov nquag metabolite hauv cov ntshav ntshav hauv cov poj niam thiab txiv neej tus txiv neej tsis txawv. Qhov sib txawv ntawm pharmacokinetic no tsis yog qhov tseem ceeb hauv tsev kho mob.
Cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm
Thaum noj ntawm lub qhov ncauj rau cov neeg mob uas mob sib khuav xws li mob cawv mus txog rau tus neeg mob ntshav siab, lub siab ntawm losartan thiab cov metabolite hauv ntshav plasma tau txiav txim siab 5-1.7 zaus, piv, piv nrog txiv neej hluas tuaj yeem pab dawb.
Qhov siab ntawm losartan nyob rau hauv cov ntshav ntshav hauv cov neeg mob nrog kev tsim lub peev xwm tshem tawm ntau dua 10 ml / min tsis txawv ntawm qhov ntawd hauv cov tib neeg uas lub raum tsis ua haujlwm. AUC hauv cov neeg mob ua rau mob hemodialysis tau nce 2 npaug piv nrog cov neeg mob uas lub raum tsis ua haujlwm. Qhov kev sib zog ntawm cov nquag metabolite hauv cov ntshav ntshav tsis hloov pauv hauv cov neeg mob uas lub raum tsis ua haujlwm lossis hauv cov neeg mob ua rau mob hemodialysis. Losartan thiab nws cov metabolite nquag tsis raug tshem tawm los ntawm hemodialysis.

Thaum cev xeeb tub thiab lactation

Cov tshuaj yog nruj me ntsis txwv tsis pub noj thaum lub sijhawm cev xeeb tubCov. Nws yuav tsum tau hloov mus rau lwm cov tshuaj tiv thaiv kabmob.

Seb cov tshuaj tawm hauv niam cov kua mis tsis paub meej. Yog li no, thaum tab tom kho nrog Cozaar pub niam mis pom zoo kom txhob ua ntxiv.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cozaar dosage daim foos-cov tshuaj pleev xim rau cov yeeb yaj kiab: dawb, lub ntsej muag kheej kheej cov ntsiav tshuaj muaj qhov sib cais tsis zoo rau ntawm ib sab thiab kos duab "952" ntawm lwm qhov, cov ntawv xa hluav taws xob tsis zoo - engraving "960" ntawm ib sab thiab ib qhov chaw zoo rau sab nraud (raws li 50 mg rau 14 pcs., 100 mg rau 7 lossis 14 pcs. Hauv cov hlwv, hauv pob ntawv qhwv ntawm 1 lossis 2 blisters).

Cov tshuaj phiv tshuaj yog losartan potassium, hauv 1 ntsiav tshuaj - 50 lossis 100 mg.

Ntu cov khoom siv: pregelatinized pob kws hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, magnesium stearate.

Lub plhaub muaj pes tsawg leeg: hypromellose, hyprolose (nrog 0.3% silicon dioxide), carnauba siv quav ciab, titanium dioxide.

Kev siv cov tshuaj Cozaar

Cozaar tuaj yeem noj tau yam tsis xav txog zaub mov noj. Cozaar tuaj yeem raug txiav txim ib txhij nrog lwm cov tshuaj tiv thaiv kabmob.
AH (kev mob ntshav siab)
Qhov ib txwm xub pib thiab kev saib xyuas cov tshuaj rau feem ntau ntawm cov neeg mob yog 50 mg 1 zaug hauv ib hnub. Qhov siab tshaj plaws antihypertensive nyhuv tiav nyob rau hauv 3-6 lub lis piam los ntawm kev pib kho. Hauv qee tus neeg mob, kom ua tiav cov lus tshaj tawm, nws yuav tsim nyog nce qhov koob tshuaj kom txog li 100 mg ib hnub ib zaug.
Thaum muab tshuaj rau cov neeg mob uas txo qis BCC (piv txwv, vim yog kev kho mob siab nrog kev tso tshuaj ntau dhau), thawj zaug yuav tsum yog 25 mg ib hnub ib zaug (saib TSHUAJ TSHWJ XEEB).
Tsis tas yuav xaiv cov koob tshuaj pib rau cov neeg laus lossis cov neeg mob raum tsis ua haujlwm, suav nrog cov neeg mob ntawm hemodialysis. Cov neeg mob uas muaj keeb kwm muaj kab mob siab yuav raug muab qis dua li kev noj tshuaj ib txwm muaj.
Txo qhov kev pheej hmoo ntawm cov teeb meem thiab lub neej tuag vim yog mob plawv rau cov neeg mob ntshav siab (ntshav siab) thiab laug ventricular hypertrophy.
Qhov ib txwm xub pib ntawm Cozaar yog 50 mg 1 zaug nyob rau ib hnub. Ua raws li qhov hloov pauv ntawm cov ntshav siab, ib qho ntxiv koob tshuaj hydrochlorothiazide siv thiab / lossis koob tshuaj Cozaar tau nce txog 100 mg ib zaug ib hnub.
Cov mob kheesxaws hauv cov neeg mob uas muaj ntshav qab zib hom II mellitus nrog proteinuria
Qhov kev pib noj ib txwm ib txwm yog 50 mg ib hnub ib zaug. Qhov kev txhaj tshuaj tuaj yeem nce ntxiv txog 100 mg ib hnub ib zaug, nyob ntawm kev hloov pauv ntawm cov ntshav siab. Cozaar tuaj yeem muaj kev sib txig sib xyaw nrog lwm cov tshuaj tiv thaiv kabmob (diuretics, calcium channel blockers, α- lossis β-adrenoreceptor blockers thiab hauv nruab nrab cov tshuaj), nrog rau cov tshuaj insulin thiab lwm cov tshuaj tiv thaiv kab mob ntshav siab (xws li sulfonylureas, glitazones thiab glucosidase inhibitors).

Kev sib cuam tshuam ntawm cov tshuaj Cozaar

Hauv cov kev tshawb fawb pharmacokinetic, tsis muaj kev sib cuam tshuam hauv kev kho mob ntawm losartan nrog hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole thiab erythromycin tau sau tseg. Warfarin thiab fluconazole tau tshaj tawm xov xwm los txo qis dua ntawm cov tshuaj tua kab mob nquag ntawm losartan. Cov kev mob tshwm sim los ntawm cov kev sib txuam tsis tau soj ntsuam.
Ib yam li lwm yam angiotensin II inhibitors, kev siv cov tshuaj potassium-sparing diuretics (spirinolactone, triamteren, amiloride), poov tshuaj uas muaj cov tshuaj ntxiv los yog ntsev ntsev tuaj yeem ua rau hyperkalemia.
NSAIDs, nrog rau xaiv COX-2 inhibitors, tuaj yeem txo cov nyhuv ntawm diuretics thiab lwm cov tshuaj tiv thaiv kev tiv thaiv. Yog li, cov nyhuv tshuaj tiv thaiv kev tsis haum tshuaj - angiotensin II receptor antagonists yuav txo qis nrog kev siv NSAIDs tib lub sijhawm, suav nrog COX-2 inhibitors.
Hauv qee tus neeg mob uas lub raum ua haujlwm tsis zoo hauv kev kho NSAIDs (suav nrog COX-2 inhibitors), kev tswj hwm ntawm angiotensin II receptor antagonists tuaj yeem ua rau txo qis dua ntawm lub raum kev ua haujlwm. Cov teebmeem no feem ntau yuav thim rov qab.

Kev txheeb xyuas txog Cozaar

Hauv cov ntawv sau npe hauv Is Taws Nem txog cov tshuaj hais lus zoo heev. Nrog kev tswj hwm zoo, cov tshuaj no ua rau cov ntshav siab thiab tsis tshua muaj kev phiv. Qhov yooj yim, nws qhov kev nkag tsawg tsis cuam tshuam nrog qhov khoom noj.

Xyuas txog Cozaar:

"Cov tshuaj ib txwm muaj, tab sis nws tsis pab tam sim ntawd, tab sis tsuas yog qee qhov puag ncig lub lim tiam thib 3 ntawm kev tswj hwm",

“Tom qab phais, Kuv tau noj Cozaar rau ib lub lim tiam. Lub siab tshem tawm ntawm 220 116 txog 130 87. Ib sab tshwm sim yog qhov tsis muaj zog, tab sis kuv ua txhaum rau tshuaj loog. Ua ntej kuv tau sim lwm cov tshuaj - lawv tsis pab kuv. "

Cov Tshuaj Pharmacokinetics

Thaum noj ntawm qhov ncauj, losartan yog qhov yaim thiab metabolized zoo heev. Nws yog qhov cim los ntawm cov nyhuv ntawm "thawj kev tso cai" los ntawm lub siab nrog kev tsim cov carboxylated metabolite nrog kev ua haujlwm pharmacological, thiab kev siv lub cev tsis muaj zog. Cov kab ke ua haujlwm ntawm lub cev hauv nruab nrog cev hauv cov tshuaj ntsiav yog kwv yees li 33%. Qhov siab tshaj plaws ntawm losartan thiab nws cov metabolite nquag tau kaw nyob rau nruab nrab tom qab 1 teev thiab 3-4 teev tom qab kev tswj hwm, ntsig txog. Thaum noj Cozaar thaum lub caij noj mov, cov ntsiab lus tsis sib haum ntawm cov nquag muaj feem hauv cov ntshav ntshav tseem tsis tau hloov pauv.

Qhov qib ntawm khi ntawm losartan thiab nws cov nquag metabolite nrog plasma protein (mas nrog albumin) nce mus txog 99%. Qhov ntim ntawm kev faib tawm ntawm losartan yog 34 litres. Kev sim ntawm cov nas ua pov thawj tias qhov kev tiv thaiv cov ntshav-lub hlwb tsis zoo rau qhov khoom seem ntawd.

Kwv yees li 14% ntawm kev txhaj tshuaj ntawm Cozaar, thaum noj ntawm qhov ncauj lossis leeg ntshav, dhau mus rau nws cov tshuaj metabolite. Ntxiv rau nws, pharmacologically tsis muaj zog metabolites tau txheeb xyuas, ntawm cov uas 2 lub ntsiab metabolites dominate, uas tau tsim vim los ntawm hydroxylation ntawm sab butyl saw, thiab ib theem pib metabolite - N-2-tetrazole-glucuronide.

Lub plasma tshem tawm ntawm cov tshuaj nquag ntawm Cozaar thiab nws cov nquag metabolite yog kwv yees li 600 ml / min thiab 50 ml / min, feem. Lub raum tshem tawm ntawm cov sib txuas yog kwv yees li 74 ml / min thiab 26 ml / min, feem. Nrog rau kev tswj hwm ntawm qhov ncauj ntawm losartan, kwv yees li 4% ntawm cov koob tshuaj tau tawm yog tsis hloov pauv hauv cov zis thiab txog 6% ntawm cov koob tshuaj tau tawm hauv tib txoj kev ntawm kev siv tshuaj tiv thaiv metabolite. Rau losartan thiab nws cov metabolite nquag, lub linearity ntawm pharmacokinetic tsis muaj qhov ncauj tswj ntawm Cozaar hauv koob tshuaj txog 200 mg yog cov yam ntxwv.

Tom qab kev tswj hwm ntawm qhov ncauj, cov ntsiab lus ntawm losartan thiab nws cov metabolite hauv plasma txo qis tshaj tawm, nrog kawg lub neej ib nrab ntawm kwv yees li 2 thiab 6-9 teev, feem. Thaum noj Cozaar hauv ib qho tshuaj ntawm 100 mg ib hnub ib zaug, kev loj hlob ntawm losartan lossis nws cov metabolite nquag tsis pom nyob hauv lub cev. Kev zam ntawm losartan thiab nws cov metabolites nquag nqa tawm los ntawm ob lub raum, nrog rau hauv cov hnyuv nrog cov kua tsib. Tom qab qhov ncauj tswj hwm ntawm losartan sau nrog 14 C atoms, hauv cov neeg mob txiv neej, kwv yees li 35% ntawm lub xov tooj cua isotope nyob hauv cov zis, thiab 58% hauv cov quav. Nrog kev tswj hwm ntawm 14 C ntawm losartan, kwv yees li 43% ntawm lub xov tooj cua tau txiav txim siab tso zis thiab 50% hauv cov quav.

Plasma losartan ntau ntau hauv cov poj niam uas mob ntshav tawm los yog 2 npaug ntau dua rau cov txiv neej uas mob ib yam. Qhov kev cia siab ntawm cov nquag metabolite hauv cov neeg mob ntawm ob tus poj niam txiv neej yuav luag tsis txawv. Txawm li cas los xij, qhov tshwm sim no tau xyaum tsis muaj qhov tseem ceeb hauv kev kho mob.

Hauv cov neeg mob uas mob sib khuav xws li cawv me ntsis mus rau lub siab nrog kev tswj hwm qhov ncauj ntawm Cozaar, cov ntsiab lus ntawm losartan thiab nws cov tshuaj tiv thaiv kab mob hauv ntshav plasma yog 5 thiab 1.7 npaug siab dua, feem ntau, ntau dua li cov txiv neej hluas noj qab haus huv uas txaus siab koom nrog kev sim.

Cov lus qhia rau kev siv Cozaar: txoj kev thiab qhov ntau npaum li cas

Cozaar ntsiav tshuaj noj ntawm qhov ncauj ib zaug ib hnub, thaum lub sijhawm yooj yim, tsis hais noj zaub mov dab tsi.

Cov koob tshuaj ntawm cov tshuaj yog cov kws kho mob sau tseg raws li kev qhia txog kev kho mob.

Pom zoo ntau npaum ntawm Cozaar:

• Arterial hypertension: 50 mg ua thawj zaug thiab thawj zaug koob tshuaj, yog tias tsim nyog, kom ua tiav cov nyhuv ntau dua, 100 mg tuaj yeem noj tau. Cov nyhuv hypotensive ruaj khov tshwm sim tom qab 3-6 lub lis piam ntawm kev kho. Rau cov neeg mob uas muaj BCC txo, qhov pib ntawm cov tshuaj yog raug txiav txim hauv 25 mg. Yog tias muaj keeb kwm ntawm daim siab pathology tau qhia, koob tshuaj yuav tsum raug txo kom tsawg. Cov neeg mob lub hnub nyoog qib siab thiab lub raum tsis ua haujlwm, suav nrog cov neeg mob lim ntshav, tsis tas yuav pib hloov kho tshuaj,
• Mob plawv tsis zoo: qhov hno thawj zaug yog 12.5 mg, titration pom zoo ib hlis ib zaug, nqa mus rau ib qho tshuaj txij nkawm (12.5 mg, 25 mg lossis 50 mg),
• Hom 2 mob ntshav qab zib mellitus nrog proteinuria: thawj koob yog 50 mg, coj mus rau hauv tus account txo qis ntshav siab (BP), qhov koob tshuaj yuav tsum maj mam nce mus txog 100 mg. Kev siv tshuaj ua ke nrog cov tshuaj diuretics, alpha thiab beta adrenoblockers, calcium channel blockers, centrally acting drugs, lwm cov kab mob hypoglycemic (glitazones, sulfonylureas, glucosidase inhibitors) thiab cov tshuaj insulin tau qhia,
• Arterial hypertension thiab sab laug ventricular hypertrophy: Thawj qhov kev txiav txim siab txo qis txoj kev pheej hmoo ntawm kev txhim kho cov kab mob ntsig txog lub plawv thiab kev tuag yog 50 mg. Muab qib ntawm kev txo qis hauv cov ntshav siab, kev kho ntxiv nrog kev nce siab ntawm kev txhaj tshuaj kom 100 mg lossis muab tshuaj tsawg kawg ntawm hydrochlorothiazide.

Sab sij huam

Hauv kev tswj xyuas cov kab mob kev nkeeg ntawm kev siv Cozaar, cov kev mob tshwm sim hauv qab no tau sau tseg:

• Los ntawm cov hlab plawv system: tachycardia, palpitations,
• Los ntawm cov txheej txheem ua pa: o ntawm lub qhov ntswg ntswg, hnoos, mob ntsws sab sauv, pharyngitis, mob ntsws,
• Los ntawm lub plab zom mov: xeev siab, dyspepsia, raws plab,
• Los ntawm cov hlab ntsha: insomnia, mob taub hau, kiv taub hau,
• Los ntawm cov leeg ua haujlwm: mob leeg, mob nraub qaum,
• Los ntawm lub cev tag nrho: qaug zog thiab tsis muaj zog, mob hauv siab thiab / lossis plab, o,
• Ntawm ib feem ntawm cov kev kuaj sim: hyperkalemia (ua kom nce siab ntawm alanine aminotransferase tom qab kev tshem tawm yeeb tshuaj feem ntau rov qab ua li qub).

Kev phiv tshuaj nrog Cozaar cov thawj coj tau sau tseg hauv kev soj ntsuam dav dav:

• Lub plab zom mov: ua rau lub siab ua haujlwm tsis zoo, tsis tshua muaj kab mob siab,
• Hematopoietic system: thrombocytopenia, ntshav liab,
• Musculoskeletal system: arthralgia, myalgia, tsis tshua muaj - rhabdomyolysis,
• Cov kab mob hauv lub cev: mob taub hau, tsis tshua muaj mob dysgeusia,
• Kab mob ntsws: hnoos,
• Kev ua kom tawv nqaij: khaus, urticaria, yaug ntawm daim tawv nqaij,
• Ua xua: tsis tshua muaj - vasculitis, Shenlein-Genoch kab mob, mob hlwb, nrog rau o ntawm lub ntsej muag txhaws qa, lub ntsej muag txhaws, nrog rau qhov cuam tshuam ntawm txoj hlab ua pa, thiab / lossis o ntawm daim di ncauj, ntsej muag, nplaig thiab / lossis pharynx (qee tus neeg mob tau tiv thaiv hypersensitivity nrog lub koob tshuaj dhau los. ACE inhibitors).

Feem ntau, Cozaar muaj kev zam zoo, cov kev mob tshwm sim yog hloov thiab nthuav tawm hauv cov qauv me uas tsis tas yuav tsum tsis txiav tawm cov tshuaj.

Pharmacological kev txiav txim siab ntawm Cozaar

Cov lus qhia rau Cozaar qhia tau hais tias cov tshuaj no muaj peev xwm txo qis peripheral vascular resistance, siab nyob rau hauv lub voj voog me me ntawm cov ntshav khiav, cov ntshav siab, tom qab ua haujlwm, thiab tseem muaj cov diuretic nyhuv.

Tsis tas li ntawd, raws li kev txheeb xyuas rau Cozaar qhia, cov tshuaj no tsis tso cai rau qhov tshwm sim ntawm myocardial hypertrophy. Rau cov neeg mob uas lub plawv tsis ua haujlwm, Cozaar yog qhov tsim tawm rau kev hloov chaw lub cev zoo dua.

Raws li kev txheeb xyuas txog Cozaar, noj cov tshuaj tsuas yog 1 zaug, tom qab 6 teev, systolic thiab diastolic ntshav siab poob qis. Cov nyhuv zoo sib xws kav ntev txog 24 teev. Txoj kev dav dav ntawm kev kho nrog rau cov tshuaj kom tau txais txiaj ntsig zoo tshaj plaws yuav tsum tsis pub tsawg dua 3-6 lub lis piam.

Tsuas tshuaj thiab tswj hwm

Raws li tau hais hauv cov lus qhia rau Cozaar, cov tshuaj yog coj ua ntej, thaum lossis tom qab noj mov. Rau kev kho kab mob tshwj xeeb, tsuas yog siv Cozaar tuaj yeem siv lossis nws tuaj yeem ua ke nrog lwm cov tshuaj uas tawm tsam kub siab.

Yog tias tus neeg mob tau mob kub siab, Cozaar kev kho mob yuav tsum tau pib nrog kev noj tshuaj ntau npaum li 50 mg tsis pub tshaj 1 zaug hauv ib hnub. Cov txiaj ntsig zoo tshaj plaws ntawm kev noj cov tshuaj no tshwm sim 3-6 lub lis piam tom qab thawj zaug kev siv tshuaj. Yog tias tsim nyog, tus kws kho mob tuaj yeem nce qhov tshuaj rau txhua hnub rau 100 mg (1 zaug hauv 24 teev).

Hauv kev tshuaj xyuas ntawm Cozaar, nws tau qhia tias cov neeg mob uas txo qis cov ntshav ncig yuav tsum pib kho nrog qhov ntau kawg ntawm 25 mg tsuas yog 1 zaug ib hnub.

Cov neeg laus, nrog rau cov neeg mob lub raum tsis txaus, uas tseem muaj lub cev lim ntshav, tsis tas yuav muaj kev hloov kho rau cov tshuaj uas qhia hauv cov lus qhia rau Cozaar.

Cov neeg mob uas muaj daim siab tsis txaus yuav tsum tau tua tus nqi txhua hnub ntawm Cozaar.

Txo qhov tshwm sim ntawm cov kab mob ntsig txog lub plawv, nrog rau kev txo qis kev tuag hauv cov neeg muaj mob laug ventricular hypertrophy thiab leeg ntshav siab, rau txhua tus neeg mob, tsis muaj kev zam, kev noj tshuaj pib ntawm 50 mg ntawm Cozaar yog tus kws kho mob tsis pub tshaj 1 zaug hauv 24 teev. Kev txheeb xyuas txog Cozaar qhia tau tias tom qab lub sijhawm ib lub sijhawm, tus kws kho mob ntxiv ib qho tshuaj me me ntawm hydrochlorothiazide, lossis koj tuaj yeem nce ntxiv Cozaar kev noj (txog li 100 mg ib hnub ib zaug). Hauv qhov no, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv tus lej ntsuas ntawm qhov txo cov ntshav siab.

Txhawm rau pab txhawb raum kev ua haujlwm nyob hauv cov neeg mob ntshav qab zib hom 2 thiab proteinuria, kev kho yuav tsum tau pib nrog tshuaj 50 mg ib hnub ib zaug. Tom qab qhov no, kev siv txhua hnub ntawm Cozaar tau nce siab txog 100 mg, thaum soj ntsuam qhov txo qis hauv cov ntshav siab. Cov tshuaj yeeb yaj kiab tuaj yeem ua ke nrog cov tshuaj insulin, diuretics, tus neeg sawv cev hauv nruab nrab, nrog rau ntau yam tshuaj tiv thaiv hypoglycemic.

Yog tias tus neeg mob tau mob plawv tsis txaus, thawj koob tshuaj Cozaar tsis pub dhau 12,5 mg thaum nruab hnub, uas txuas ntxiv txhua hnub thaum thawj lub lim tiam ntawm kev kho mob. Hauv lub lim tiam thib ob, ntau npaum li cas ntxiv rau 25 mg rau ib hnub, hauv peb - ​​txog li 50 mg rau ib hnub.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Muab 25 muaj qhov sib npaug ntawm 25 mg ntawm losartan potassium. Txhua lub ntsiav tshuaj dawb yog oval, coated nrog zaj duab xis, cim 951 ntawm ib sab.

Cov tshuaj noj nrog qhov ntau npaum ntawm 50 qhov txawv ntawm qhov tsis muaj zog 25 ntsiav tshuaj los ntawm daim ntawv lo thiab cov tshuaj muaj zog hauv 50 mg ntawm potassium losartan. Txhua lub thauv tshuaj dawb muaj oval, zaj duab xis-txheej, cim 952

Cov ntsiav tshuaj nrog qhov siab tshaj plaws ntawm 100 mg losartan potassium muaj cov tsos mob ntawm cov ntsiav tshuaj dawb hauv daim ntawv ntawm ib qho poob nrog cov cim ntawm 960

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov kev tshawb fawb los soj ntsuam qhov cuam tshuam ntawm Cozaar ntawm kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem nyuaj tsis tau coj los ua. Txawm li cas los xij, thaum noj ib chav kawm ntawm kev kho mob tiv thaiv kab mob siab, ceeb toom yog qhia thaum tsav tsheb lossis ua haujlwm uas muaj kev phom sij uas yuav tsum muaj kev xav ntau ntxiv thiab cov kev cuam tshuam ntawm lub hlwb tam sim ntawd. Qhov no cuam tshuam nrog kev pheej hmoo ntawm kiv taub hau thiab qaug zog thaum noj cov tshuaj, tshwj xeeb tshaj yog thaum pib kho lossis nrog qhov nce ntxiv ntawm koob tshuaj.

Txujci thiab kev thov nta

Cozaar yog siv tsis hais txog ntawm lub sijhawm noj zaub mov, nws tsuas yog ib qho tseem ceeb kom ua raws li txoj kev xaiv ntawm kev noj cov tshuaj txhua hnub. Cov kev qhia tau pom zoo kom nqos tau cov tshuaj yam tsis tau ntxo nrog dej haus.

Nyob ntawm seb tus neeg mob mob li cas, kev xav siv cov tshuaj nyob hauv ib hnub yog xaiv. Cov theem pib koom nrog kev siv cov koob tshuaj ntawm 50 lossis 100 mg ntawm Cozaar hauv 24 teev. Cov kab mob ntawm kev muab tshuaj txo qis qis ntawm cov tshuaj ntawm 25 mg rau ib hnub yog paub. Nruj me ntsis ua raws li cov lus qhia rau kev siv thiab tsis pub dhau ib koob tshuaj 100 mg hauv 24 teev. Tus nqi tshuaj ntawm cov tshuaj yog txiav txim los ntawm tus kws khomob tuaj koom.

Cov qauv kev cai rau cov neeg mob 6 mus txog 16 xyoo yog xam raws li lub cev qhov hnyav ntawm tus menyuam.

• 20-49 kg cov cai ntawm kev noj tshuaj yog 25 mg rau ib hnub, tuaj yeem nce rau 50 mg rau ib koob tshuaj ib hnub.
• 50 kg thiab ntau dua - 50 mg ib hnub twg, tuaj yeem nce txog 100 mg rau ib hnub.

Tsis tas yuav hloov pauv lub koob tshuaj pib rau cov neeg mob raum tsis ua haujlwm thiab cov uas mob hemodialysis.

Yog tias muaj kev ua txhaum ntawm daim siab ua haujlwm ntawm lub siab hauv tus neeg mob lub keeb kwm kho mob, ib qho koob tshuaj qis dua yuav tsum raug txiav txim.Clinically kev paub dhau los hauv kev siv tau zoo thiab muaj kev nyab xeeb ntawm Cozaar tshuaj hauv cov neeg mob uas mob raum tsis zoo, yog li ntawd, nws cov sijhawm teem rau pawg neeg mob no tau sib kis.

Hauv cov neeg mob uas muaj hnub nyoog ntau dua 75 xyoos, qhov yuav tsum tau txhaj 25 mg thawj zaug, txawm hais tias yuav tsum tau kho ntau npaum li cas los tsis tas rau cov neeg mob no.

Cev xeeb tub thiab lactation

Raws li cov lus qhia, Cozaar yog txwv tsis pub sau ntawv thaum cev xeeb tub. Kev siv tshuaj hauv II thiab III txiav tawm cev xeeb tub uas muaj kev cuam tshuam cov kab mob renin-angiotensin tuaj yeem ua rau muaj mob tsis txaus los yog tuag taus ntawm kev xeeb tub hauv plab, yog li ntawd, cov tshuaj tau muab tshem tawm tam sim ntawd tom qab tsim qhov tseeb ntawm cev xeeb tub. Cov hlwv hlaws muaj feem cuam tshuam nrog kev txhim kho ntawm cov renin - angiotensin system tshwm sim hauv tus me nyuam hauv lub hlis thib ob. Txoj kev pheej hmoo rau tus me nyuam hauv plab tau nce ntxiv yog tias Cozaar raug noj nyob rau zaum ob lossis thib peb ntawm cev xeeb tub.

Tsis txhob pom zoo kev kho mob thaum lub sijhawm lactation. Cov kev paub ntawm kev siv losartan hauv pawg no ntawm cov neeg mob yog qhov tsis txaus, thiab nws tseem tsis tau paub tseeb tias cov tshuaj mus rau hauv niam mis. Yog li, nws yog ib qho tsim nyog yuav tsum cuam tshuam nrog cov txiaj ntsig zoo ntawm kev kho mob rau leej niam thiab cov kev pheej hmoo rau tus menyuam thiab txiav txim siab txog kev txiav kev pub mis niam lossis kev rho tawm ntawm Cozaar.

Yeeb tshuaj sib cuam tshuam

Cov chaw muaj kab mob tseem ceeb ntawm Cozaar nrog digoxin, warfarin, hydrochlorothiazide, cimetidine, ketoconazole, phenobarbital, erythromycin tsis tau tsim.

Cov nyhuv ntawm qhov txo qis hauv qib ntawm cov tshuaj lom neeg lub cev nquag thaum noj fluconazole thiab rifampicin ntawm kev soj ntsuam cov tshuaj tsis tau kawm txog.

Kev tswj hwm tib lub sijhawm ntawm cov tshuaj potassium, triamteren, spironolactone, amiloride thiab lwm yam tshuaj uas tiv thaiv kev tsim cov tshuaj angiotensin II, cov tshuaj ntsev muaj cov poov tshuaj, tuaj yeem pab txhawb kev nce ntxiv hauv cov qib potassium hauv cov ntshav.

Thaum ua ke nrog cov roj ntsha lithium, losartan txo qis kev nthuav dav thiab nce nws cov ntshav dej siab.

Cov tshuaj tsis-steroidal anti-inflammatory (NSAIDs), xaiv COX-2 cyclooxygenase inhibitors txo cov nyhuv hypotensive ntawm cov tshuaj.

Hauv cov neeg mob uas lub raum tsis zoo lub ntsws, kev siv tshuaj thiab NSAIDs ntau, nrog rau xaiv COX-2 inhibitors, tuaj yeem txuas ntxiv mus rau lub raum. Cov nyhuv ntawm qhov kev sib txuam no yog qhov thim rov qab.

Ib qho kev txo qis hauv plasma qhov ntau ntawm cov metabolite nquag thaum siv fluconazole thaum ua ke nrog Cozaar ua rau kom cov concentration ntawm losartan hauv ntshav plasma nce ntxiv.

Cozaar's analogues yog: Blocktran, Lozap, Losartan, Lorista, Angizar, Kardomin-Sanovel, Giperzar, Ksartan, Klosart, Lozartin, Losar, Presartan, Pulsar, Erinorm, Advantan, Votum, Aprovel, Vazar, Valsacor, Vanatex, Vanatex Irbetan, Candesar, Cantab, Kasark, Mikardis, Teveten, Firmasta, Hizart, Edarbi.

Cev xeeb tub Siv

Cov poj niam cev xeeb tub yuav tsum tsis txhob noj Cozaar vim tias kev noj tshuaj yuav muaj kev phom sij rau tus menyuam hauv plab. Yog tias koj npaj yuav cev xeeb tub, tham nrog koj tus kws kho mob lwm yam tshuaj uas koj tuaj yeem siv los tswj koj cov ntshav siab. Yog tias kev xeeb tub tshwm sim thaum noj cov tshuaj, tsum tsis ua qhov kev kho tam sim ntawd thiab nrhiav tswv yim kho mob.

Kuj tsis paub meej tias losartan yuav kis mus rau leej niam mis li cas. Muab qhov txaus ntshai ntawm cuam tshuam rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, koj yuav tsum nres kev pub mis rau lub sijhawm ntawm kev siv tshuaj.

Cia rau cov neeg mob

Khaws cov tshuaj kom deb ntawm kev tshav ntuj ntawm qhov kub tsis tshaj 30 degrees Celsius hauv qhov chaw me nyuam yaus thiab tsiaj txav tsis tau.

Txhua ntsiav tshuaj tuav ntsig txog 25, 50, lossis 100 mg ntawm poov tshuaj losartan nquag khoom xyaw. Raws li cov khoom xyaw ntxiv, microcrystalline cellulose thiab hydrated lactose, pregelatinized hmoov txhuv nplej siab, magnesium stearate thiab hydroxyproxy cellulose thiab hydroxyproxy methyl cellulose, titanium dioxide, carnauba siv quav ciab.