Oxodoline (Oxodoline)

Thoob ntiaj teb lub npe:Oxodoline

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Ntsiav tshuaj 1 ntsiav tshuaj muaj 50 mg ntawm chlortalidone.

Hauv cov hlwv qhwv ntsej muag ntim ntawm 50 ntsiav tshuaj. Ntim rau hauv thawv ntawv thawv.

Cov chaw soj ntsuam thiab chaw muag tshuaj

Cov tshuaj pab pawg kho mob

Pharmacological kev txiav txim ntawm cov tshuaj Oxodolin

Thiazide-zoo li diuretic, muaj qhov ua kom ntev ntev. Nws cuam tshuam los ntawm kev tso dej rov qab los ntawm sodium ions, chlorine thiab qhov sib npaug ntawm cov dej hauv cov raj tub distal. Tsis tas li ntawd, nws tsub kom muaj kev nthuav dav ntawm cov poov tshuaj, magnesium, bicarbonate ions los ntawm lub cev, ncua kev tsim tawm ntawm uric acid, calcium ions. Belongs rau diuretics ntawm nruab nrab efficiency. Lub diuretic nyhuv pib tom qab 2 teev, nce mus txog qhov siab kawg tom qab 12 teev thiab kav ntev txog 72 teev. Nws ua rau txo qis ntshav siab. Cov nyhuv antihypertensive nthuav dav zuj zus, mus txog qhov siab kawg tom qab 2-4 lub lis piam. tom qab tau pib kho. Tsis tas li ntawd, chlortalidone ua rau txo qis polyuria nyob rau hauv cov neeg mob ntshav qab zib insipidus, txawm hais tias nws cov tshuab ntawm kev ua tsis tau elucidated.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, chlortalidone yog nqus los ntawm cov hnyuv. Kev nqus tsis ruaj khov. Nws khi rau cov qe ntshav liab kom txog qib siab, khi rau cov ntshav muaj protein ntau yog qhov tsawg tshaj tawm.

T 1/2 ntev, 40-60 teev.

Nws yog tawm hauv feem ntau hauv kev hloov pauv tsis tau nrog zis.

Hauv cov neeg mob laus, kev nthuav tawm qeeb qeeb, piv nrog cov neeg mob ntawm cov tub ntxhais hluas thiab hnub nyoog nruab nrab, kev nqus tsis hloov.

II theem CHF, mob ntshav siab, mob ntshav siab nrog portal hypertension, nephrosis, nephritis, lig gestosis (nephropathy, edema, eclampsia), kua dej cia nyob rau tom qab ntawm premenstrual syndrome, ntshav qab zib insipidus, dysproteinemic edema, rog rog.

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv tsis haum ntshav (suav nrog rau sulfonamide derivatives), hypokalemia, mob raum tsis ua haujlwm (mob hlwb), mob txhaws qa, mob siab, mob ntshav qab zib, ntshav qab zib mellitus (mob hnyav), gout, lactation Ceev faj. Mob raum thiab / lossis daim siab tsis ua haujlwm, kev phiv tshuaj, mob ntsws asthma, SLE.

Dosage regimen thiab cov qauv ntawm daim ntawv thov Oxodoline

Nruab ib tus zuj zus. Nrog kev mob ntshav arterial tawg - 25 mg 1 lub sijhawm / hnub. Yog tias tsim nyog, qhov koob tshuaj yuav raug nce ntxiv rau 50-100 mg / hnub. Thaum ncav qhov ua tau zoo, lawv hloov mus rau kev saib xyuas kev kho mob hauv qhov tsawg kawg. Nrog edematous syndrome, ib qho koob tshuaj ntawm 50-100 mg yog siv 1 zaug / hnub, yog tias tsim nyog, txog 200 mg, tom qab ua tiav cov nyhuv, lawv hloov mus rau kev kho kho.

Sab sij huam

Los ntawm lub plab zom mov: muaj peev xwm xeev siab, ntuav, raws plab, cem quav, tsis qab los.

Los ntawm ob sab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb peripheral: mob taub hau, tsis muaj zog, caj dab tes taw, kiv taub hau yog ua tau.

Los ntawm cov dej-electrolyte tshuav: hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypercalcemia yog ua tau.

Los ntawm sab ntawm cov metabolism: tau hyperuricemia, hyperglycemia.

Los ntawm cov kab ke hemopoietic: tsis tshua muaj - thrombocytopenia, leukopenia.

Kev kho kom haum Dermatological: daim tawv nqaij ua pob xoos tuaj yeem ua tau.

Cev xeeb tub thiab lactation

Nkag tau los ntawm thaj chaw siab. Thaum cev xeeb tub yog contraindicated nyob rau hauv txoj hlab ntshav tawg. Hauv lwm qhov xwm txheej, kev siv yog ua tau tsuas yog ua raws li cov lus qhia nruj me ntsis ntawm qhov kev siv tshuaj tsawg kawg nkaus thiab thaum xav tias yuav muaj txiaj ntsig ntawm txoj kev kho rau leej niam outweighs qhov kev pheej hmoo rau tus me nyuam hauv plab.

Chlortalidone ua rau hauv niam cov kua mis. Yog tias tsim nyog, siv thaum lactation, pub mis niam yuav tsum tsis ua mus ntxiv.

Daim ntawv thov rau lub siab ua haujlwm tsis zoo Ua rau lub siab ua haujlwm tsis zoo hauv lub siab ua rau lub raum tsis ua haujlwm. Siv cov kev ceev faj thaum muaj qhov ua tsis taus lub zog raum rov ua haujlwm.

Siv rau cov neeg mob laus

Siv nrog ceev faj hauv cov neeg laus.

Cov lus qhia tshwj xeeb rau kev txais neeg kawm Oxodoline

Thaum lub sijhawm kev kho mob, nws yog ib qho tsim nyog los txiav txim siab cov ntshav electrolytes, tshwj xeeb tshaj yog nyob rau cov neeg mob noj digitalis npaj. Nws tsis pom zoo kom sau cov zaub mov ntsev kom nruj rau cov neeg mob. Yog tias muaj cov tsos mob ntawm tus mob hypokalemia (myasthenia gravis, lub suab tsis sib xws) lossis yog tias cov neeg mob muaj qhov tseem ceeb ntawm K + poob (nrog ntuav, raws plab, tsis muaj teeb meem noj zaub mov, mob ntsws, hyperaldosteronism, ACTH txoj kev kho, GCS), kev hloov kho nrog K + tshuaj yog qhia. Hauv cov neeg mob hyperlipidemia, cov lipids ntshiab yuav tsum tau saib xyuas tas li (yog tias lawv qhov kev nce siab ntxiv, kev kho yuav tsum tsis ua ntxiv). Nrog thiazide diuretics, hais txog qhov tsis zoo ntawm SLE tau sau tseg. Txawm hais tias cov xwm txheej zoo li no tsis tau pom muaj chlortalidone, kev ceeb toom yuav tsum tau siv thaum kho nws rau cov neeg mob SLE.

Kev sib cuam tshuam nrog Lwm Yam Tshuaj

Nrog rau kev siv ua ke nrog corticosteroids, amphotericin B, carbenoxolone, qhov pheej hmoo ntawm kev loj hlob hypokalemia nce ntxiv.

Nrog rau kev siv nrog NSAIDs, kev txo qis ntawm diuretic thiab antihypertensive cuam tshuam ntawm chlortalidone yog ua tau.

Nrog rau kev siv digitalis npaj txhij, nws muaj peev xwm nce kev pheej hmoo ntawm kev phiv tshuaj lom neeg ntawm kev npaj digitalis vim yog hypokalemia vim kev ua ntawm chlortalidone.

Nrog rau kev siv lithium carbonate tib lub sijhawm, kev ua siab loj ntawm lithium hauv cov ntshav ntshav thiab cov kev pheej hmoo ntawm lithium intoxication nce.

Kev siv cov tshuaj Oxodolin tsuas yog raws li kws kho mob tau hais tseg, qhov lus qhia tau muab rau siv!

Cov cim qhia dab tsi kom nkag siab tias tus neeg muaj kev puas siab puas ntsws?

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, chlortalidone yog nqus los ntawm cov hnyuv. Kev nqus tsis ruaj khov. Nws khi rau cov qe ntshav liab kom txog qib siab, khi rau cov ntshav muaj protein ntau yog qhov tsawg tshaj tawm.

T 1/2 ntev, 40-60 teev.

Nws yog tawm hauv feem ntau hauv kev hloov pauv tsis tau nrog zis.

Hauv cov neeg mob laus, kev nthuav tawm qeeb qeeb, piv nrog cov neeg mob ntawm cov tub ntxhais hluas thiab hnub nyoog nruab nrab, kev nqus tsis hloov.

Tshuaj los qhia

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, cem quav, poob qab los yog qhov ua tau.

Los ntawm sab hauv nruab nrab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb txhaws: mob taub hau, tsis muaj zog, plab caj dab, kiv taub hau yog ua tau.

Ntawm ib feem ntawm cov dej-electrolyte sib npaug: hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypercalcemia yog ua tau.

Los ntawm ib sab ntawm cov metabolism: muaj peev xwm ua hyperuricemia, hyperglycemia.

Los ntawm cov kab mob hemopoietic: tsis tshua muaj - thrombocytopenia, leukopenia.

Kev mob tshwm sim hauv daim tawv nqaij: ua pob rau daim tawv nqaij ua tau.

Cev xeeb tub thiab lactation

Nkag tau los ntawm thaj chaw siab. Thaum cev xeeb tub yog contraindicated nyob rau hauv txoj hlab ntshav tawg. Hauv lwm qhov xwm txheej, kev siv yog ua tau tsuas yog ua raws li cov lus qhia nruj me ntsis ntawm qhov kev siv tshuaj tsawg kawg nkaus thiab thaum xav tias yuav muaj txiaj ntsig ntawm txoj kev kho rau leej niam outweighs qhov kev pheej hmoo rau tus me nyuam hauv plab.

Chlortalidone ua rau hauv niam cov kua mis. Yog tias tsim nyog, siv thaum lactation, pub mis niam yuav tsum tsis ua mus ntxiv.

Cov lus qhia tshwj xeeb

Nws yog siv nrog ceev faj hauv cov neeg mob ntshav qab zib mellitus, nrog gout, mob hnyav atherosclerosis ntawm cov hlab ntshav thiab cov hlab ntsha hauv lub cev, cov leeg tsis ua haujlwm lub raum tsis ua haujlwm, hauv cov neeg laus.

Hauv cov txheej txheem kev kho mob, nws yog ib qhov tsim nyog los tswj cov ntshav ntshav, cov ntshav electrolyte muaj pes tsawg leeg ntawm cov ntshav, theem ntawm uric acid, cov piam thaj hauv cov ntshav.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Chlortalidone, tshwj xeeb tshaj yog thaum pib kho, tej zaum yuav cuam tshuam lub peev xwm los tsav tsheb thiab siv tshuab ua haujlwm.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv ua ke nrog corticosteroids, amphotericin B, carbenoxolone, qhov pheej hmoo ntawm kev loj hlob hypokalemia nce ntxiv.

Nrog rau kev siv nrog NSAIDs, kev txo qis ntawm diuretic thiab antihypertensive cuam tshuam ntawm chlortalidone yog ua tau.

Nrog rau kev siv digitalis npaj txhij, nws muaj peev xwm nce kev pheej hmoo ntawm kev phiv tshuaj lom neeg ntawm kev npaj digitalis vim yog hypokalemia vim kev ua ntawm chlortalidone.

Nrog rau kev siv lithium carbonate tib lub sijhawm, kev ua siab loj ntawm lithium hauv cov ntshav ntshav thiab cov kev pheej hmoo ntawm lithium intoxication nce.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

nyob rau hauv ib lub blister ntim ntawm 10 pcs., nyob rau hauv ib pob ntawm cardboard 5 pob los yog nyob rau hauv lub khob tsaus tsaus ntawm 50 pcs., nyob rau hauv ib pob ntawm cardboard 1 hub.

Cov Tshuaj Hauv Tshuaj

Nws inhibits active reabsorption ntawm sodium ions (Na +), feem ntau nyob rau hauv peripheral raum tubules (cortical ntu ntawm Henle voj), nce ntxiv kev tsis haum ntawm sodium ions (Na +), chlorine ions (Cl -) thiab dej. Kev nthuav tawm ntawm cov calcium ions (K +) thiab magnesium ions (Mg 2+) los ntawm ob lub raum nce ntxiv, thaum lub caij nyoog ntawm cov calcium ions (Ca 2+) tsawg dua.

Nws ua rau txo qis ntshav siab, qhov hnyav ntawm cov nyhuv hypotensive maj mam nce thiab tau pom meej meej 2-4 lub lis piam tom qab pib kho.

Thaum pib ntawm txoj kev kho, nws ua rau muaj qhov txo qis hauv cov dej ntawm cov kua dej ntxiv, BCC, thiab feeb cov ntshav ntawm cov ntshav, txawm li cas los xij, tom qab siv ntau lub lis piam, cov ntsuas no rov qab mus rau ib theem ze rau qhov pib ib.

Zoo li thiazide diuretics, nws ua rau txo qis polyuria nyob rau hauv cov neeg mob uas mob raum ntshav qab zib insipidus.

Qhov pib ntawm kev ua yog 2-4 teev tom qab noj, qhov siab tshaj plaws ua haujlwm yog tom qab 12 teev, lub sijhawm ua ntawm 2-3 hnub.

Cov Yuav Tsum Muaj

mob siab tsis haum (suav nrog rau sulfonamide derivatives),

cov hom phiaj loj zuj zus ntawm tsis muaj tus mob nephrosis thiab nephritis nrog kev txo qis ntawm cov txha caj qaum glomerular,

mob raum tsis ua hauj lwm nrog anuria,

mob hepatic coma, mob siab,

mob ntshav qab zib mellitus (cov ntawv hnyav),

kev ntxhov siab hauv cov dej-electrolyte tshuav,

cov menyuam yaus hnub nyoog qis dua 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis pom zoo).

lub raum thiab / lossis daim siab ua haujlwm,

mauj lupus erythematosus,

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, gastrospasm, cem quav los yog raws plab, mob cholestasis, mob daj ntseg, txha nqaj liab.

Los ntawm lub paj hlwb: kiv taub hau, mob caj dab, ua tsis haum ntshav (txawv txawv lossis qaug zog), tsis meej pem, tsis quav ntsej.

Ntawm qhov txhia chaw: lub qhov muag pom tsis zoo (suav nrog xanthopsia).

Ntawm ib feem ntawm cov ntshav thiab cov ntshav tsim cov kabmob: thrombocytopenia, leukopenia, agranulocytosis, eosinophilia, mob ntshav tsis txaus.

Los ntawm cov kab mob plawv: orthostatic hypotension (yuav nce nyob rau hauv kev cuam tshuam ntawm ethanol, tshuaj loog, tshuaj tuag sedative), arrhythmia (vim hypokalemia).

Kev ntsuas ntsuas: hypokalemia, hyponatremia (suav nrog nrog cov tsos mob neurological - xeev siab), hypomagnesemia, hypochloremic alkalosis, hypercalcemia, hyperuricemia (gout), hyperglycemia, glucosuria, hyperlipidemia.

Kev tsis haum tshuaj: urticaria, photosensitivity.

Lwm yam: leeg nruj, txo qis potency.

Kev sib txuam

Nws tsub kom cov concentration ntawm lithium ions (Li +) hauv cov ntshav (nyob rau hauv rooj plaub thaum Li + ua rau polyuria, nws tuaj yeem muaj antidiuretic nyhuv) thiab, yog li, nce qhov kev pheej hmoo nrog intoxication nrog Li + tshuaj.

Txhim kho cov txiaj ntsig ntawm curariform cov leeg ua kom mob thiab cov tshuaj tiv thaiv kabmob (nrog rau guanethidine, methyldopa, beta-blockers, vasodilators, BKK), MAO inhibitors.

Thaum noj cov tshuaj glycosides, nws tuaj yeem ua rau mob plawv dhia tsis txaus uas ua los ntawm digitalis intoxication.

Kev ua haujlwm hypokalemic ntawm cov tshuaj yog txhim kho nrog kev tswj hwm ntawm GCS, amphotericin, carbenoxolone.

NSAIDs ua rau lub zog hypotensive thiab diuretic nyhuv ntawm cov tshuaj.

Tawm tsam keeb kwm yav dhau los ntawm kev siv chlortalidone, ib qho kev kho (nce los yog txo qis) hauv koob tshuaj insulin lossis nce qhov ntau ntawm cov tshuaj ntawm qhov ncauj hypoglycemic yuav tsum tau

Tsuas tshuaj thiab tswj hwm

Sab hauv (feem ntau thaum sawv ntxov, ua ntej noj tshais). Cov koob tshuaj raug xaiv ib tus zuj zus, nyob ntawm qhov mob hnyav thiab qhov ntawm tus kab mob thiab cov txiaj ntsig tau txais. Nrog rau kev kho kom ntev, nws raug nquahu kom kho cov tshuaj qis qis qis kom txaus kom tswj tau qhov pom kev zoo (tshwj xeeb tshaj yog nyob rau cov neeg laus laus).

Nrog kev mob me me ntawm kev kub siab - 50 mg ib hnub ib zaug 3 zaug hauv ib lub lis piam.

Nrog edematous syndrome: qhov pib koob tshuaj yog 100 mg txhua hnub nyob rau lwm hnub (koob tshuaj ntau dua 100 mg feem ntau tsis ua rau muaj kev nce ntxiv hauv cov diuretic nyhuv), kev saib xyuas txij nkawm yog 100-120 mg ib hnub 3 zaug hauv ib lub lis piam.

Nrog lub raum daim ntawv ntawm cov ntshav qab zib insipidus: thawj koob tshuaj yog 100 mg 2 zaug nyob rau ib hnub, kev saib xyuas txij nkawm yog 50 mg rau ib hnub.

Noj ntau dhau

Cov tsos mob kiv taub hau, xeev siab, tsaug zog dhau lawm, hypovolemia, muaj ntshav siab ntau, ntshav tsis txaus, ua kom qaug dab peg.

Kev Kho Mob: pais plab lav, kev teem sij hawm ntawm tshuab hluav ncaig hluav taws xob, kev kho mob uas tsis pom kev (nrog rau iv kev ua kom muaj cov ntsev ua kom rov qab los kho cov roj hauv ntshav).

Pharmacological kev txiav txim

Nws ua rau kev tsuj ntawm kev rov ua haujlwm ntawm cov dej qab ntsev ntawm cov sodium ions, feem ntau nyob rau hauv cov hlab pas hlab, ua rau muaj kev cuam tshuam ntau ntawm chlorine, sodium thiab dej ions. Kev nthuav tawm ntawm cov calcium ions los ntawm ob lub raum poob, thiab ions ntawm magnesium thiab potassium ntxiv.

Ua rau lub siab me ntsis hauv qhov siab. Qhov mob hnyav ntawm cov nyhuv hypotensive nce nce zuj zus, thiab tag nrho tshwm sim nws tus kheej tsuas yog ob mus rau plaub lub lis piam tom qab pib kho.

Nws ua rau muaj zog txo qis hauv cov ntshav feeb, BCC thiab cov kua dej ntxiv, tab sis cov nyhuv no tsuas pom thaum pib kho. Tom qab ob peb lub lis piam, cov ntsuas coj los ua tus nqi ze rau qhov qub.

Zoo li thiazide diuretics, nws pab txo cov polyuria hauv cov neeg mob uas mob ntshav qab zib raum insipidus.

Cov tshuaj pib ua yeeb yam ob mus rau plaub teev tom qab kev tswj hwm ntawm qhov ncauj. Qhov siab tshaj plaws tau tiav tom qab kaum ob teev. Lub sijhawm ua ntawm txawv txav ntawm ob txog peb hnub.

Kev nqus - 50 feem pua ​​hauv 2.6 teev. Bioavailability yog 64 feem pua. Plasma protein khi yog 76 feem pua. Tom qab noj cov tshuaj ntawm 100 los sis 50 mg, Cmax tau mus txog tom qab 12 teev thiab yog 16.5 thiab 9.4 mmol / L, ntsig txog.

Qhov kev tshem tawm ib nrab-lub neej txawv ntawm 40 mus rau 50 teev. Nws yog tawm tawm tsis hloov pauv los ntawm ob lub raum. Nws kis tau rau hauv niam cov kua mis. Tej zaum yuav ntau zuj zus nyob rau hauv lub raum tsis ua hauj lwm.

Kev ntsuas rau siv

Oxodolin yog tseg rau:

• jade, nephrosis,
• leeg ntshav siab
• mob siab mob ntsws nrog portal tawg,
• mob plawv tsis ua hauj lwm qib II,
• dysproteinemic edema,
• raum daim ntawv mob ntshav qab zib insipidus,
• rog dhau.

Kev Sau ua ke, daim foos tso tawm

Muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj dawb. Lub ntsej muag daj tuaj yeem tso cai. Cov ntsiav tshuaj tau muab tso rau hauv cov thawv dub khob lossis hauv qhov ua hlwv, thiab tom qab ntawd hauv cov thawv ntawv thawv.

Tus nquag ua hauj lwm hauv oxodoline yog chlortalidone. Cov khoom xyaw pabcuam muaj xws li: qos yaj ywm hmoov txhuv nplej siab, mis qab zib (lactose), calcium stearic acid (calcium stearate), cov roj ntshav hnyav polyvinylpyrrolidone.

Cov lus cog tseg, sijhawm khaws cia

Nyob rau hauv qhov chaw txias, tiv thaiv los ntawm lub teeb.

Niaj hnub no nws nyuaj rau nrhiav Oxodolin hauv cov chaw muag tshuaj Lavxias, yog li nws tsis tuaj yeem kos cov lus xaus ntawm tus nqi ntawm cov tshuaj.

Lub tsev muag tshuaj Ukrainian tshuaj Oksodolin tsis paub txog.

Cov tshuaj hauv qab no yog txhais rau cov tshuaj: Gigroton, Urandil, Edemdal, Hydronal, Isoren, Oradil, Renon, Urofinil, Apochlortalidon, Chlortalidone, Chlorphthalidolone, Famolin, Igroton, Natriuran, Phthalamidine, Saluretin, Zambezil.

Raws li kev txheeb xyuas, ib tus tuaj yeem txiav txim siab tau txais txiaj ntsig ntawm Oxodoline. Cov neeg mob siab kub siab txog tshuaj kho kom zoo.

Kev tshuaj xyuas ntawm cov kws kho mob uas tau sau cov tshuaj rau lawv cov neeg mob paub meej txog qhov tseeb no.

Cov kev tsis haum lub ntsej muag tshwm sim tsis xws luag, yog tus cwj pwm tsis muaj qhov hnyav. Raws li cov kws kho mob, Oxodolin yog qhov tsim nyog rau kev kho mob ntev.

Txheeb xyuas qhov tshuaj ntsuam xyuas tshuaj tiag tom kawg ntawm qhov taub. Qhia tawm koj cov kev xav txog Oxodoline yog tias koj tau coj nws lossis kho nws.

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj
Diuretic tus neeg sawv cev. Nws inhibits active reabsorption ntawm sodium ions (Na +), mas nyob rau hauv peripheral raum tubules (cortical ntu ntawm lub Henle voj), ua rau kev nthuav dav ntawm Na +, chlorine ions (SG) thiab dej. Kev nthuav tawm ntawm cov calcium ions (K +) thiab magnesium ions (Mg 2+) los ntawm ob lub raum nce ntxiv, thaum muaj kev zam rau cov calcium ions (Ca 2+) poob qis. Nws ua rau txo qis ntshav siab (BP), qhov hnyav ntawm cov nyhuv hypotensive maj mam nce thiab muaj qhov cuam tshuam tag nrho 2-4 lub lis piam tom qab pib kho.
Thaum pib ntawm txoj kev kho, nws ua rau muaj qhov txo qis ntawm cov kua dej ntxiv, qhov ntim ntawm cov ntshav thiab cov feeb ntshav, txawm li cas los xij, tom qab ob peb lub lis piam ntawm kev siv, cov ntsuas no rov qab mus rau ib qib ze rau qhov qub.
Zoo li thiazide diuretics, nws ua rau txo qis polyuria nyob rau hauv cov neeg mob uas mob raum ntshav qab zib insipidus.
Qhov pib ntawm kev ua yog 2-4 teev tom qab noj, cov nyhuv siab tshaj plaws yog tom qab 12 teev, lub sijhawm ua ntawm 2-3 hnub.

Cov Tshuaj Pharmacokinetics
Kev Nqa - 50% rau 2.6 teev. Bioavailability yog 64%. Tom qab qhov ncauj tswj hwm ntawm 50 mg thiab 100 mg, qhov siab tshaj plaws tau mus txog tom qab 12 teev thiab yog 9.4 thiab 16.5 mmol / L, raws. Kev sib txuas lus nrog cov protein plasma - 76%.
Kev tshem tawm ib nrab-lub neej yog 40-50 teev .Nws yog tawm los ntawm lub raum tsis hloov pauv. Ua kom muaj kua mis. Hauv mob raum tsis ua haujlwm, nws tuaj yeem khaws ntau ntxiv.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Nrog rau kev kho kom ntev, nws raug nquahu kom kho cov tshuaj qis qis qis kom txaus kom tswj tau qhov pom kev zoo, tshwj xeeb tshaj yog nyob rau cov neeg laus.

Nrog rau qhov kev mob sib khuav xwb ntawm cov ntshav tawm - 25 mg ib hnub ib zaug lossis 50 mg 3 zaug hauv ib lub lis piam, yog tias tsim nyog, qhov kev txhim kho ntau ntxiv txog 50 mg / hnub yog ua tau.

Hauv cov tsos mob edematous, qhov pib koob tshuaj yog 100-120 mg txhua lwm hnub, nyob rau hauv cov mob hnyav, 100-120 mg / hnub rau thawj ob peb hnub (koob tshuaj saum toj no 120 mg feem ntau tsis ua rau muaj kev nce ntxiv ntawm cov nyhuv diuretic), tom qab ntawd nws yog qhov yuav tsum hloov mus rau kev saib xyuas txij nkawm ntawm 100- 50-25 mg / hnub 3 zaug hauv ib lub lis piam.

Cov ntshav qab zib raum insipidus (rau cov neeg laus): thawj koob - 100 mg 2 zaug ib hnub, koob tshuaj txij nkawm - 50 mg rau ib hnub.

Qhov nruab nrab txhua hnub rau cov menyuam yog 2 mg / kg.