Sandostatin: hais txog kev siv rau pancreatitis

Kev piav qhia cuam tshuam rau 05.08.2015

Lub npe Latin: Sandostatin
ATX Code: H01CB02
Yam tshuaj muaj sia: Octreotide
Chaw tsim tshuaj paus: Novartis Pharma (Switzerland)

1 ml ntawm kev daws rau iv thiab s / c tswj hwm muaj 50, 100 lossis 500 μg ntawm cov tshuaj nquag octreotide.

1 vial ntawm microspheres rau kev npaj qhov ncua ntawv rau i / m tswj hwm Sandostatin Lar muaj 10 mg ntawm cov nquag tivthaiv hauv daim ntawv octreotide acetate.

Tsuas tshuaj thiab tswj hwm

Sandostatin yog tshuaj rau cov neeg mob tom qab phais mob pancreatic nrog exacerbation ntawm pancreatitis. Cov tshuaj kho mob txo qhov mob, vim tias qhov txo qis hauv kev tsim cov enzymes nres cov txheej txheem ntawm kev rhuav tshem cov ntaub so ntswg.

Hauv daim ntawv uas mob hlaws vwm, Sandostatin tswj xyuas tus mob ntawm cov neeg mob, pab txhawm rau txo cov qaug dab peg. Sandostatin hauv ampoules yog muab rau cov neeg mob subcutaneously, intramuscularly, mob ntshav los ntawm infusion 3 zaug hauv ib hnub. Droppers yog ua nyob nruab nrab ntawm cov zaub mov thiab ua ntej yuav mus pw. Cov lus qhia ntawm Sandostatin yog nqa tawm ib teev ua ntej kev ua haujlwm thiab tsis pub dhau 7 hnub tom qab nws. Cov koob tshuaj yog tshuaj los ntawm tus kws kho mob mus kawm ntawm tus kheej, nyob ntawm seb qhov xwm ntawm cov chav kawm ntawm tus kab mob. Cov tshuaj pib ua 5 feeb tom qab pib txoj kev lis ntshav.

Sab sij huam

Nrog Sandrostatin txoj kev kho, phiv tuaj yeem tshwm sim. Los ntawm kev mob plab zom mov, xeev siab, ntuav, tso quav tsis txaus, pom kev, ua paug, mob plab, cov tsos ntawm cov pob zeb hauv lub plab, qhov nce ntawm cov ntsiab lus ntawm bilirubin thiab daim siab enzymes hauv cov ntshav, thiab mob hauv plab yog tau. Muaj peev xwm txog hlab plawv, hlab ntsha hlwb thiab endocrine:

hypothyroidism (tsis txaus ntseeg lub qog ua haujlwm),
metabolic mob ntawm cov piam thaj hauv lub cev,
bradycardia (lub plawv dhia qeeb),
lub plawv dhia,
mob taub hau.

Nrog intolerance mus rau Cheebtsam ntawm Sandostatin, kev tsis haum tshuaj tuaj yeem tshwm sim.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog kev ceev faj, Sandostatin yuav tsum tau siv ua ke nrog beta-blockers thiab tshuaj diuretic. Thaum ua ke nrog cyclosporine, cov nyhuv ntawm tom kawg txo. Sandostatin nrog cov kua dej yog tshuaj nrog kev ceev faj. Hauv qhov no, nws yog ib qhov tsim nyog los tswj cov piam thaj hauv cov ntshav. Sandostatin txo qis kev nqus ntawm cimetidine. Cawv tsis pub sib hais. Cov tshuaj tsis cuam tshuam rau kev tsav tsheb.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj nquag ntawm cov tshuaj yog octreotide, uas yog ib qho hluavtaws sib piv ntawm cov tshuaj hormones somatostatin. Cov tshuaj tso tawm nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj (ampoules) lossis lyophilisate, los ntawm kev daws teeb meem.

Ib qho ampoule nrog qhov ntim ntawm 1 ml muaj ib koob tshuaj 0.05-0.1 mg ntawm qhov tshuaj nquag. Ntxiv nrog rau cov tshuaj tiav, cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm hmoov, uas yog diluted ua ntej siv nyob rau hauv qhov yuav tsum tau ua.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv tshuaj lub koob npe ntawm Sandostatin tso tawm yog kev daws teeb meem rau kev tswj hwm ntawm qhov quav thiab subcutaneous: tsis muaj xim, pob tshab (hauv ampoules ntawm 1 ml, hauv ib pob ntawv los ntawm 5 lossis 10 ampoules).

Cov lus sib xyaw ntawm 1 ml ntawm cov tshuaj:

cov tshuaj nquag: octreotide (raws li peptide pub dawb) - 50, 100 lossis 500 μg,
cov khoom siv ntxiv: sodium bicarbonate, lactic acid, mannitol, carbon dioxide, dej rau kev txhaj tshuaj.

Cov Tshuaj Hauv Tshuaj

Cov tshuaj nquag ntawm Sandostatin yog octreotide - ib qho hluavtaws octapeptide, ib qho analogue ntawm lub ntuj hormone somatostatin, uas muaj cov teebmeem zoo sib xws ntawm cov tshuaj, tab sis lub sijhawm ntev dua ntawm kev nqis tes ua.

Octreotide suppresses tso pa tawm ntawm kev loj hlob hormone (GH), ob qho tib si pathologically nce thiab tshwm sim los ntawm cov tshuaj insulin hypoglycemia, kev siv lub cev, thiab kis rau arginine. Sandostatin tseem ua rau cov tshuaj insulin tsis pub lwm tus, serotonin, gastrin thiab glucagon, nce pathologically lossis vim zaub mov noj. Txhawb nqa kev zais cia ntawm glucagon thiab insulin tsa los ntawm arginine, nrog rau kev zais thyrotropin tshwm sim los ntawm thyroliberin.

Tsis zoo li somatostatin, octreotide suppresses qhov zais cia ntawm GR rau ntau dua li insulin secretion. Cov tshuaj tsis ua rau kev txo qis ntawm cov tshuaj hormones (piv txwv, kev loj hlob hormone hauv cov neeg mob uas muaj acromegaly). Nrog acromegaly, Sandostatin txo cov ntshav plasma ntau npaum li GH thiab insulin-zoo li qhov kev loj hlob zoo (IGF-1). Hauv 90% ntawm cov neeg mob, muaj qhov txo qis ntawm cov ntsiab lus ntawm GH los ntawm tsawg kawg 50%, thaum qib GH qis dua 5 ng / ml tuaj yeem ua tiav nyob hauv thaj tsam li 50% ntawm tus neeg mob. Hauv feem ntau cov neeg mob uas muaj acromegaly, cov tshuaj txo qis o ntawm cov nqaij mos, qhov mob mob taub hau thiab hyperhidrosis, paresthesia thiab mob pob txha. Nrog rau cov nplais qog adenomas, Sandostatin tuaj yeem txo qhov me me ntawm cov qog loj.

Octreotide tuaj yeem txhim kho cov kab mob ntawm tus neeg mob thaum tsis muaj txiaj ntsig ntawm txoj kev kho (hepatic artery embolism, phais, tshuaj kho mob, suav nrog 5-fluorouracil thiab streptozotocin) ntawm secretory endocrine hlav ntawm lub plab hnyuv thiab txiav. Yog li, nrog cov qog carcinoid, Sandostatin txo qhov mob ua kom mob plab zom mov thiab hnov zoo ntawm lub ntsej muag, uas feem ntau nrog los ntawm kev poob qis hauv plasma concentration ntawm serotonin thiab tsis ua haujlwm ntawm 5-hydroxyindoleacetic acid hauv cov zis. Nrog cov qog VIP nrog hyperproduction ntawm vasoactive plab hnyuv peptide (VIP), cov yeeb tshuaj hauv feem ntau txo cov ntaub ntawv tsis pub muaj mob plab zom mov thiab, yog li ntawd, txhim kho cov neeg mob lub neej zoo. Nyob rau tib lub sijhawm, kev cuam tshuam tsis sib haum xeeb hauv kev ntsuas hluav taws xob (piv txwv li, hypokalemia) yuav txo qis, uas ua rau nws tuaj yeem tshem tawm qhov kev tswj hwm ntawm niam txiv thiab nkag ntawm cov roj ntsha thiab kua dej. Hauv qee tus neeg mob, Sandostatin ua rau qeeb qeeb thiab txawm tias nres qhov kev mob qog, txo nws qhov loj me, ntxiv rau qhov loj me ntawm daim siab metastases. Cov chaw kho mob txhim kho, raws li txoj cai, nrog nrog txo qis lossis ib txwm ua ntawm lub plasma concentration ntawm VIP.

Nrog glucagonomas, octreotide txo erythema tsiv teb tsaws. Ntawm cov ntshav qab zib mellitus, cov tshuaj tsis cuam tshuam loj heev rau qhov mob siab rau hyperglycemia, yog li qhov xav tau rau cov neeg mob hypoglycemic lossis insulin feem ntau tseem tsis hloov. Vim tias txo qis raws plab, qhov nce hauv lub cev qhov hnyav yog ua tau. Thiab txawm hais tias qhov txo qis ntshav plasma concentration ntawm glucagon nyob rau hauv lub zog ntawm Sandostatin yog qhov hloov mus rau qhov xwm, qhov kev txhim kho hauv cov chaw kho mob tau ruaj khov nyob rau txhua lub sijhawm ntawm kev siv tshuaj.

Hauv kev mob plab gastrinomas / Zollinger-Ellison syndrome, kev siv octreotide ua ib yam tshuaj lossis ua ke nrog histamine H blockers₂-kev siv tshuaj lossis cov twj tso kua mis tshuaj tiv thaiv tuaj yeem ua rau txo qis qis ntawm hydrochloric acid nyob rau hauv lub plab, qhov txo qis ntawm cov tshuaj lom ntawm gastrin hauv cov ntshav plasma thiab qhov hnyav ntawm kub taub hau thiab raws plab.

Hauv cov neeg mob insulinomas, Sandostatin pab txo qis ntawm cov tshuaj tiv thaiv insulin hauv cov ntshav (cov nyhuv no tuaj yeem ua luv luv, txog 2 teev). Nyob rau hauv qhov muaj cov qog ua haujlwm, cov tshuaj tuaj yeem ua kom rov zoo thiab tswj hwm tus kabmob normoglycemia hauv lub sijhawm preoperative. Nrog kev mob loj tsis tuaj yeem thiab cov hlav qog, glycemic tswj tau zoo tuaj yeem tsis muaj lub sijhawm ua ke txo qis hauv insulin concentration hauv cov ntshav.

Hauv cov neeg mob uas tsis tshua muaj cov qog uas ua haujlwm dhau los ntawm kev loj hlob hormone tso qhov kev faib tawm (somatoliberinomas), Sandostatin txo qhov mob hnyav ntawm acromegaly cov tsos mob, vim nws inhibits kev zais ntawm kev loj hlob hormone tso qhov zoo tshaj tawm thiab kev loj hlob hormone nws tus kheej. Nyob rau hauv lub neej yav tom ntej, txo qis ntawm pituitary hypertrophy tseem muaj peev xwm ua tau.

Thaum los ntshav los ntawm ntau txoj hlab ntsha ntawm txoj hlab pas thiab lub plab hauv cov neeg mob qog mob ntshav, ntxiv rau octreotide mus rau ib qho kev kho mob tshwj xeeb (piv txwv, rau sclerotherapy) tuaj yeem cuam tshuam ntau dua los ntshav thiab tiv thaiv kev rov ua kom ntxov, txo qhov ntim ntawm kev hloov ntshav thiab txhim kho 5-hnub muaj sia nyob. Nws ntseeg tau tias cov txheej txheem ntawm kev nqis tes ua ntawm Sandostatin yog vim qhov txo qis hauv cov ntshav hloov khoom nruab nrog vim yog kev cuam tshuam ntawm vasoactive hormones xws li glucagon thiab VIP.

Hauv cov neeg mob uas tau qhia rau kev phais mob pancreatic, Sandostatin, siv thaum lub sijhawm thiab tom qab phais mob, txo qhov tshwm sim ntawm qhov mob tom qab (xws li, mob nraub qaum, mob caj pas hauv hlab ntsws, fistula, sepsis, mob qog nqaij hlav).

Nrog rau kev mob plab zawv plab hauv cov neeg mob uas Tau Txais Tshuaj Tiv Thaiv Kab Mob (AIDS), Sandostatin tag nrho lossis ib feem ntawm cov quav li ntawm 30% ntawm cov mob thaum mob plab tsis tuaj yeem tswj tau nrog kev tiv thaiv kabmob txaus thiab / lossis tshuaj tua kabmob txaus.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm subcutaneous, octreotide yog nrawm thiab ua kom tiav. Qhov siab tshaj plaws ntshav plasma nce mus txog hauv 30 feeb.

Nrog cov plasma protein khi rau 65%. Kev sib txuas lus nrog cov qe ntshav yog qhov tsis tshua lees ntseeg. Kev faib khoom ntim - 0.27 l / kg. Kev tshem tag nrho yog 160 ml / min.

Tom qab txhaj tshuaj subcutaneous, ib nrab-lub neej (T_½) - 100 feeb Kev tshem tawm cov tshuaj tom qab kev tswj hwm kev saib xyuas yog nqa tawm hauv ob ntu, T_½ yog 10 thiab 90 min, feem. Qhov ntau dua ntawm cov tshuaj tau tso rau hauv cov quav, txog 32% - nrog tso zis tsis hloov pauv.

Kev ntsuas rau siv

acromegaly: nrog kev ua haujlwm tsis txaus ntawm kev xoo hluav taws xob / kev kho mob txhawm rau txhawm rau tswj tau qhov tseem ceeb ntawm tus kabmob thiab qis dua GR (kev loj hlob hormone) thiab IGF-1 (insulin-zoo li kev loj hlob) hauv ntshav, yog tias tus neeg mob tsis kam ua haujlwm lossis yog muaj contraindications rau nws siv, luv kev kho mob hauv nruab nrab ntawm cov kev kawm ntawm kev kho hluav taws xob kom txog rau thaum lub sij hawm nws cov nyhuv raug tiav,
secreting endocrine hlav hlav ntawm lub plab hnyuv (lub plab zom mov) thiab tus kabmob (rau kev tswj hwm tus cwj pwm): VIPs, glucagonomas, carcinoid qog tshwm sim nrog carcinoid syndrome, insulinomas (rau kev kho txoj kev kho thiab rau kev tswj ntshav qab zib hauv lub sijhawm puag ncig), somatoliberin , uas yog pom los ntawm hyperproduction ntawm kev tso tawm GR), gastrinomas / Zollinger - Ellison syndrome (feem ntau ua ke nrog kev siv histamine H blockers₂receptors thiab proton twj tso kua mis inhibitors). Nws yuav tsum tau yug hauv siab tias Sandostatin tsis yog cov tshuaj antitumor, thiab nws txoj kev siv tsis ua rau kev kho mob ntawm pawg neeg no,
refractory raws plab hauv cov neeg mob AIDS (los tswj cov tsos mob),
muaj teeb meem tom qab phais mob pancreatic (rau kev tiv thaiv),
los ntshav los ntawm ntau txoj hlab ntaws ntawm lub plab thiab txoj hlab pas nrog rau lub siab ua mob rau daim siab (ua ke nrog qee cov kev kho mob tshwj xeeb (piv txwv, endoscopic sclerotherapy) kom tsis txhob los ntshav thiab tiv thaiv kom tsis txhob mob ntxiv).

Cov Yuav Tsum Tau Ua

Qhov tseeb contraindication rau kev kho mob yog qhov muaj lub siab tsis haum rau cov tshuaj ntawm cov tshuaj.

Raws li cov lus qhia, Sandostatin yuav tsum siv nrog ceev faj hauv cov xwm txheej hauv qab no:

mob cholelithiasis,
mob ntshav qab zib mellitus
cev xeeb tub
lub sijhawm pub niam mis.

Kho thaj chaw

Nqe: los ntawm 1750 txog 1875 rubles.

Cov tshuaj muaj cov nyhuv antithyroid rau lub cev, thaum tsim tawm ntawm cov tshuaj hormones xws li TSH thiab STH raug txo qis, uas muaj txiaj ntsig zoo rau kev nthuav tawm ntawm cov nyhuv antispasmodic. Sandostatin muaj qhov tshwj xeeb ua rau txoj hnyuv - nws txo qhov kom zoo thiab tsim cov kua txiv. Raws li cov tshuaj ntawm cov tshuaj no, kev txwv tsis pub muaj kev zais ntawm serototin thiab kev loj hlob hormone (kev tsim tawm ntawm cov uas ua haujlwm ncaj qha los ntawm endocrine system), nrog rau peptides, yog tau pom.

Cov tshuaj cuam tshuam rau kev sib txuas ntawm kev loj hlob hormone thaum insulin hypoglycemia, inhibits zais cia ntawm glucogan, gastrin, qee qhov peptides, nrog rau cov tshuaj insulin. Octreotide tshem tawm cov txheej txheem ntawm thyrotropin ntau lawm hauv qab ntawm thyroliberin. Tom qab kev tswj hwm ntawm cov tshuaj hauv qab daim tawv nqaij, qhov tshuaj tiv thaiv hormonal hypersecretion tsis tau sau cia.

Hauv cov neeg muaj kev txom nyem los ntawm acromegaly, cov tshuaj no txo tsis tau tsuas yog qhov ntsuas kev loj hlob hormone, tab sis kuj somatomedin A hauv cov ntshav. Ua los ntawm kev kho mob tuaj yeem kho qhov qub theem ntawm kev loj hlob hormone hauv 50% ntawm cov neeg mob.

Hauv cov neeg mob uas muaj cov qog nqaij hlav, qhov hnyav ntawm cov yam ntxwv ntawm tus yam ntxwv tau txo qis ntau dua, cov tshuaj tswj hwm qhov theem ntawm serotonin, lub plab zom mov normalizes, thiab "dej ntws" yog tshem tawm.

Nyob rau hauv pathologies cov yam ntxwv los ntawm kev tso pa tawm ntawm vasoactive plab hnyuv peptide, noj octreiotide txhim kho qhov zoo, thiab electrolyte tshuav rov zoo li qub nrog kev kho mob. Nws yog tsim nyog sau cia tias nyob rau qee qhov teeb meem kev loj hlob ntawm tus kab mob nres, qhov ntim ntawm neoplasm poob, qhov kev pheej hmoo ntawm kev sib kis metastases mus rau lub siab txo qis.

Cov neeg mob nyob nrog kev mob plab zawv pom tias qhov kev txo qis tseem ceeb rau nws vim qhov kev kho mob nrog octreotide. Ua tsaug rau qhov no, nws muaj peev xwm ua kom lub cev qhov hnyav, ua kom qhov qis ntawm glucagon hauv lub cev. Sandostatin feem ntau pom zoo kom siv ua ke nrog H2 receptor blockers, nrog rau cov tshuaj tiv thaiv proton twj tso kua mis, uas nyob rau hauv lem muaj qhov cuam tshuam zoo ntawm qhov mob ntawm ntau cov tsos mob thiab theem ntawm gastrin (ib qho kev txo qis tau pom).

Raws li tshuaj ntawm cov tshuaj, qhov txo qis ntawm cov tshuaj tiv thaiv kab mob insulin raug sau cia rau hauv cov neeg kuaj mob insulinoma (ib qho txiaj ntsig zoo tau pom nyob hauv 2 teev). Cov neeg muaj neoplasm khiav lag luam nco ntsoov cov txij nkawm ntawm normoglycemia tom qab kev phais.

Nrog kev tsim ntau dhau ntawm kev loj hlob hormone tso tawm yam, txo qis hauv qhov hnyav ntawm cov cim ntawm acromegaly raug kuaj. Cov nyhuv no tau tiav los ntawm inhibiting qhov kev loj hlob hormone, nrog rau nws tso tawm. Tom qab, qhov ntim ntawm hypertrophied pituitary caj pas txo.

Nrog kev kho mob Sandostatin, mob nkees raug tshem tawm, yav dhau los pom tias mob taub hau ploj, cov tsos mob ntawm hyperhidrosis, mob mob hauv cov pob txha thiab pob qij txha, nrog rau cov hlab ntsws txhaws ib nrab ploj.

Phiv thiab haus tshaj

Thaum kho, kev txhim kho kev mob plab, tawm tsam xeev siab, raws plab, ua kom haum plab, nce ntxiv ntawm qib microsomal enzymes, steatorrhea, alopecia tsis tau txiav txim siab. Ib qho mob tiv thaiv kab mob siab, kab mob siab, hyperbilirubinemia, qhov nce ntawm GGT index yuav raug kaw tseg.

Tom qab kev kho mob ntev ntev, kev tso kua nplaum tawm yuav txo qis, muaj teeb meem nrog pancreatitis, hypoglycemia, kev txhim kho ntawm cholelithiasis, kev ua xua, nrog rau qhov tshwm sim ntawm kev pheej tshwm sim hyperglycemia yog tau.

Nws yog tau tias qhov kev hnov mob hlawv, qhov tsos ntawm cov mob hauv zos, o ntawm qhov chaw txhaj tshuaj.

Plab tsis xis nyob
Cov kev tshwm sim ntawm "nthwv dej"
Bouts ntawm xeev siab
Txo lub plawv dhia
Mob pob txha caj dab.

Kev kho mob uas qhia tau yog qhia.

F-Synthesis, Russia

Nqi los ntawm 616 txog 23800 rub.

Octreotide yog cov tshuaj zoo ib yam li Sandostatin, uas muaj cov roj somatostatin zoo li lub cev. Nws yog qhia rau kev kho thiab tiv thaiv ntawm ntau yam kab mob endocrine. Nws yog tsim nyob rau hauv daim ntawv ntawm kev txhaj tshuaj.

Pros:

Yuav muab tshuaj rau tus mob pancreatitis uas tshwm sim tom qab phais
Tiv thaiv kev txhim kho ntawm postoperative sepsis
Tshem tawm cov mob raws plab hauv AIDS.

Cons:

Hyperbilirubinemia tej zaum yuav tsim thaum kho
Yuav tsis xyaw nrog cawv.
Tso tawm los ntawm kev kho mob.

Ntaub Ntawv Txog Tshuaj Yeeb

Sandostatin yog hluavtaws analogue ntawm tib neeg somatostatin. Hauv tib neeg lub cev, qhov khoom noj protein no yog tsim nyob rau hauv ob qho chaw: hypothalamus thiab hauv endocrine islets ntawm lub txiav. Cov tshuaj lom neeg lub cev no muaj lub zog txwv tsis pub tsim cov tshuaj hormones ntau ib zaug: thyrotropin thiab kev loj hlob hormone, thiab kuj tseem txo cov tshuaj insulin, cholecystokinin, gastrin, glucagon.

Cov tshuaj tseem ceeb ntawm cov tshuaj Sandostatin yog octreotide, qhov hluavtaws sib piv ntawm cov tshuaj no yog yam ntxwv ntev tshaj li ntuj somatostatin.

Sandostatin yog tsim nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj lossis lyophilisate rau nws txoj kev npaj. Ib qho ampoule nrog qhov ntim ntawm 1 ml tuaj yeem muaj koob tshuaj 0.05 mg lossis 0.1 mg ntawm cov tshuaj nquag.

Cov npe ntawm qhov ntsuas rau siv

Raws li cov lus qhia rau cov tshuaj, kev siv tshuaj Sandostatin yog tswj hwm los ntawm cov chaw tsim khoom hauv rooj plaub hauv qab no:

Acromegaly.
Cov qog endocrine-ua cov qog ntawm cov txiav thiab mob plab hnyuv (Zollinger-Ellison syndrome, cov qog nqaij hlav carcinoid nyob rau hauv muaj cov mob carcinoid syndrome, VIPoma, insulinoma, thiab lwm yam).
Los ntshav los ntawm varicose leeg ntawm txoj hlab pas (ua ib feem ntawm kev kho mob zoo).
Tiv thaiv kev cuam tshuam ntawm cov neeg mob nyob rau hauv kev tiv thaiv pancreatic.

Saib xyuas! Sandostatin tsis muaj cov khoom ntawm cov tshuaj antitumor thiab tsis tuaj yeem siv los ua kev kho mob rau cov mob oncological pathologies.

Kev cuam tshuam nrog lwm yam tshuaj

Txij li thaum Sandostatin muaj cov kab ke ua rau tus neeg mob lub cev, nws txoj kev siv yuav xav tau koob tshuaj hloov qee lwm yam tshuaj uas tus neeg mob tau txais tam sim no.

Vim muaj peev xwm ntawm cov tshuaj hormones rau cuam tshuam rau lub plawv dhia thiab lub suab vascular, kev txhim kho ntawm antiarrhythmics (beta blockers) thiab cov kab mob antihypertensive (calcium channel blockers, diuretics, thiab lwm yam) feem ntau xav tau.

Kev siv bromocriptine nyob rau hauv parallel nrog Sandostatin ua rau kev txhim kho hauv qhov kev nyab xeeb ntawm no ergot alkaloid. Tab sis piv rau lwm cov tshuaj ergot, cov nyhuv yog qhov sib txawv kiag li: kev sib xyaw ntawm Cyclosporin nrog Sandostatin ua rau txo qis ntawm kev nqus ntawm cytostatic.

Kuj tseem muaj kev hloov kho rau cov tshuaj uas txo cov ntshav qab zib, thiab yog tias tus neeg mob tau txais cov tshuaj insulin, ces yuav tsum rov qab txiav nws cov tshuaj noj kom tsawg.

Sandostatin ua rau lub cev tsis zoo rau qhov nqus cov cimetidine thiab txo qis cov teeb meem ntawm cov tshuaj hauv cov tshuaj uas tawm los ntawm cytochrome system.

Pancreatitis thiab nws cov kev kho mob

Pancreatitis (mob ua mob rau daim leeg) tshwm sim vim kev noj zaub mov tsis zoo, haus dej haus cawv thiab haus kas fes ntau, siv qee yam tshuaj, kab mob ntawm cov kab mob biliary, thiab lwm yam teeb meem. Qhov no nosology muaj ob hom kev sib txawv: mob hnyav thiab mob ntev, kev kho ntawm uas nws txawv ntau.

Lub ntsiab lus ntawm pancreatitis yog kev rhuav tshem ntawm lub txiav los ntawm zom cov enzymes, uas nws kuj ua tau. Feem ntau, kev txhim kho ntawm cov kev tsis sib haum xeeb no yog cuam tshuam nrog kev thaiv cov dej ntws ntawm cov kua txiv hmab txiv ntoo los ntawm cov kua dej mus rau hauv cov hnyuv, uas ua rau cov tsub zuj zuj ntawm cov enzymes hauv cov lobules uas ua rau lawv, ua haujlwm ua ntej ntawm lub zog thiab kev puas tsuaj ntawm cov ntaub so ntswg.

Sandostatin muaj qhov cuam tshuam uas ua rau lub zais tsis ua haujlwm ntawm cov txiav, yog li ntawd, cov kws phais mob feem ntau muab nws rau cov neeg mob hnyav uas tau txais kev phais mob rau tus mob ua kom tsis muaj qab hau.

Qhov no tso cai rau koj kom txo qis cov tsos mob mob, txij li txo qis ntawm kev tsim cov zom cov zaub mov ua rau lub zog txo qis ntawm cov txheej txheem ntawm kev rhuav tshem ntxiv ntawm cov ntaub so ntswg ntawm qhov hloov khoom nruab nrog.

Kev mob loj rau lub cev, tus kab mob ntawm kev puas tsuaj yog loj heev, xws li cov neeg mob yuav tsum tau mus pw hauv tsev kho mob sai rau kev txhoj puab heev, kev txuag thiab feem ntau phais mob. Yog hais tias cov chav kawm ntawm tus kab mob no hnyav dua, nrog lub sij hawm ntawm exacerbation thiab attenuation ntawm cov tsos mob, ces feem ntau peb tab tom hais txog mob txha caj dab. Nws tuaj yeem tsim kho rau ntau xyoo thiab ntau caum xyoo, txij li cov txheej txheem inflammatory cuam tshuam rau thaj chaw me me ntawm tus txiav. Nyob rau tib lub sijhawm, hauv kev mob caj dab ntev, kev rhuav tshem ntawm cov ntaub so ntswg yog tau txawm tias tsis muaj qhov ua rau pom tseeb ntawm tus kab mob.

Txawm hais tias qhov tseeb hais tias kev siv Sandostatin rau kev mob caj dab ntev tsis tau piav qhia hauv kev qhia rau kev siv, qee zaum nws raug hais qhia rau cov neeg mob thaum mob hnyav. Xws li kev kho kom zoo tso cai rau tus neeg mob kom sai sai sai, tab sis kev coj ua tsis cuam tshuam qhov nquag thiab lub sijhawm ntawm exacerbations yav tom ntej. Txawm li cas los xij, feem ntau cov kws kho mob nyiam tsis siv Sandostatin hauv kev kho mob ntawm cov neeg mob ntev, vim nws yuav tsum xaiv txoj kev ntau npaum li cas thiab muaj tus lej ntawm cov lus tsis sib haum thiab tsis zoo lub neej.

Cov tshuaj noj

Sandostatin yog cov tshuaj noj tshuaj thiab yuav tsum tau saib xyuas kom zoo. Ua ntej pib txoj kev kho mob, nws raug nquahu kom kuaj ntshav ib zaug, nrog rau kev kuaj mob ultrasound ntawm lub plab thiab lub ntsws. Hauv lub neej yav tom ntej, cov kev sim no yuav tsum tau rov ua dua kom ntsuas cov txiaj ntsig ntawm Sandostatin ua rau lub cev.

Sandostatin muab cov tshuaj subcutaneously, intramuscularly lossis raws li cov leeg ntshav 3 zaug hauv ib hnub, nws raug tso cai rau tshuaj yaj yeeb nrog dej rau kev txhaj tshuaj, tab sis tsis muaj qhov tshwj xeeb nrog kua qab zib. Cov lus qhia yuav tsum yog daim ntawv qhia ntawm cov zaub mov noj, nrog rau ua ntej yuav mus pw, yog li txo qhov muaj feem ntawm kev txhim kho feem ntawm kev phiv.

Cov koob tshuaj ntawm cov tshuaj raug xaiv nruj me ntsis ntawm tus kheej, nyob ntawm tus kab mob thiab qhov mob hnyav ntawm nws cov chav kawm.

Lub sijhawm sijhawm ntawm kev kho mob nrog Sandostatin nyob ntawm nosology thiab tuaj yeem nyob li 5 txog 7 hnub txog rau ntau lub hlis. Yog li txhawm rau tiv thaiv kom tsis txhob muaj kev phom sij rau cov neeg mob uas mob hnyav ua rau tus kws phais mob txiav tawm ntawm tus txiav, Sandostatin yuav tsum tau yam tsawg ib teev ua ntej kev phais thiab tsis pub dhau xya hnub tom qab nws.

Cov vis dis aus tham txog lub mechanism ntawm kev ua ntawm Sandostatin:

Cov lus qhia tshwj xeeb

Cov mob rov huam mob tshwm sim tsis yooj yim hauv kev kho mob ntawm cov neeg mob gastroentero-pancreatic endocrine neoplasms.

Nrog kev kuaj xyuas cov leeg txha caj qaum, yuav tsum ua tib zoo saib xyuas cov neeg mob kom raws sij hawm txhawm rau nrhiav kev mob qog thiab nqaim pom teb.

Hauv cov neeg mob kuaj mob tshuaj insulinomas cim nce rau qhov loj thiab ntev ntshav qogCov. Nrog cov lus qhia ntawm Sandostatin hauv nruab nrab ntawm ntu ntawm pluas noj, nrog rau thaum yuav mus pw, nws muaj peev xwm txo qhov feem ntau ntawm kev phiv los ntawm cov hnyuv.

Nrog kev kho mob ntev ntawm acromegaly, ib qho kev kuaj mob ultrasound ntawm kev mob yog qhov yuav tsum tau ua gall zais zis rau kev kuaj mob raws sij hawm ntawm tus mob gallstone. Nws tsis pom zoo kom muab kev txhaj tshuaj thaum lub sijhawm luv ntawm tib qho chaw.

Sandostatin thaum pub mis niam thiab xeeb menyuam hauv plab yog tsim raws li kev qhia tseeb.

Nrog rau kev tswj hwm ntau dua ntawm cov koob tshuaj me me, muaj kev cuam tshuam txawv hauv cov piam thaj hauv qab no yuav zam tau. Thaum kho, kev saib xyuas cov ntshav qab zib tsis tu ncua yuav tsum muaj.

Sandostatin LAR tsis tuaj yeem muab cov tshuaj pleev ib ce, nws yog siv cov tshuaj intramuscularly (zoo dua li gluteus maximus). Yog tias nkag mus rau hauv cov hlab ntsha, yuav tsum hloov cov rab koob thiab thaj chaw txhaj tshuaj.

Yam tshuaj dab tsi kho tau lub plab mob

Ib qho ntawm feem nrov thiab ntev siv pab pawg ntawm cov tshuaj yog antacids. Cov tshuaj no suav nrog cov tshuaj ua kom lub cev tsis xws li ua kom lub plab cov kua qaub ntau dhau. Qhov no suav nrog sodium bicarbonate, lossis ci dej qab zib. Qhov kom zoo ntawm cov tshuaj yog nyob rau hauv kev cuam tshuam tam sim ntawd ntawm cov kua qaub, qhov tsis zoo yog nyob rau hauv provocation ntawm alkaline kev hloov pauv hauv lub cev yog los ntawm kev nqus ntawm cov dej qab tsis hnov qab.

Calcium carbonate yog ib qho tshuaj muaj zog dua li cov tshuaj tau piav saum toj no, tab sis nws muaj cov nyhuv zoo sib xws. Cov tshuaj noj nrog siv ntev ntev ua rau cem quav thiab zaum ob.

Cov tshuaj tiv thaiv kab mob rau lub plab mob tseem muaj cov hlau oxide, magnesium trisilicate, aluminium hydroxide. Cov tshuaj yeeb dej caw no muaj cov nqus thiab ua kom zoo. Alkalizing ntsiab lus muaj nyob hauv cov tshuaj xws li Vicalin, Bellgin, Bekarbon, Vikair, Almagel, Fosfalugel, Maaloks.

Qhov txiaj ntsig antacid yog los txo lub siab thiab mob, tshwm sim los ntawm qhov txo qis hauv acidity ntawm cov ntsiab lus ntawm lub plab. Cov nyhuv ntawm cov tshuaj no nyob ntawm lawv cov peev xwm alkalizing thiab kav ntev li 20 mus rau 60 feeb. Cov tshuaj zoo tshaj plaws hauv cov tshuaj me me txog 6 zaug hauv ib hnub ua ntej noj mov thiab thaum tsaus ntuj. Txo cov tsos mob ntawm tus kab mob, antacids ua rau lub cev tsis muaj zog pab kho qhov mob rwj thiab tsis cuam tshuam rau qhov ua rau muaj tus mob.

Lub plab zais pa blockers

Cov tshuaj tawm tsam lub plab mob ntawm pab pawg no muaj cov tshuaj cimetidine. Nws thaiv cov hlab ntsha reflex thiab cov tshuaj hormones hormonal uas ua rau cov tsim muaj cov kua roj hydrochloric acid. Raws li cov cimetidine, Ranitidine, Nizotidine, Famotidine thiab ntau lwm yam analogues yog tsim.

Hauv qab ntawm cov tshuaj no, kev tsim cov pepsin thiab hydrochloric acid muaj kev ntseeg siab, thiab mob thiab mob plab yog tshem tawm. Qhov kev txiav txim pib tam sim ntawd tom qab siv cov tshuaj, qhov mob ploj tom qab 5 hnub, ntuav thiab kub siab - tom qab ib lim tiam. Cov qog nqaij hlav pib kho zoo nyob rau 4-6 lub lis piam, uas nrawm dua li thaum siv lwm yam tshuaj. Cov kev mob tshwm sim me.

Pharmacological pawg secretion blockers

Cov tshuaj no rau lub plab zom mov muaj qhov tsis tseem ceeb. Ntxiv nrog rau kev thaiv cov hlab zais, lawv cuam tshuam rau lwm qhov system thiab kabmob. Cov tshuaj yog pab nyob rau hauv kev kho mob rau sab hauv. Lub ntuj tso tshuaj ntsuab yog belladonna extract, uas muaj atropine. Cov khoom siv no tsis tsuas yog txo cov khoom tsim muaj cov kua roj hydrochloric acid, tab sis kuj txo lub cev muaj zog kev ua haujlwm ntawm lub plab. Belladonna extract yog ib feem ntawm kev npaj xws li Bellalgin, Bellastesin, Bekarbon.

Cov tshuaj platifillin, nrog rau cov metacin, cais tawm los ntawm nplooj snowdrop, muaj cov nyhuv tsawg dua. Lawv daws cov mob plab zom mov thiab maj mam txo qis nws lub zais.

Gastrocepin lossis pirenzepine pab tiv thaiv kom rov zoo thiab kho qhov mob. Qhov khoom siv no ua tau zoo, ntev ntev txo kev ua kom muaj kua qaub, muaj kev cuam tshuam zoo rau lub plab zom mov.

Kev tsim cov kua qaub nyob rau hauv cov qe ntshav hauv qhov ncauj yog qhov tsis zoo los ntawm kev kho mob tshiab rau lub plab mob - Omeprazole. Nws tsim cov nyhuv ntev, yog siv rau kev kho kho. Cov tshuaj hormones tshiab "Sandostatin", "Octreotide", nrog rau cov diuretic "Diakarb" ua rau txo qis kev zais cia.

Lub plab zom mov: kho nrog cytoprotective siv yeeb siv tshuaj

Pab pawg no suav cov tshuaj noj uas tiv thaiv lub hlwb ntawm lub plab ua zaub mov. Lawv tshwj xeeb tshaj yog siv rau mob voos, thaum tiv thaiv thaj chaw ntawm lub hnoos qeev txha tsawg. Muaj ntau ntau ntawm cytoprotectoral hom. Ib txhia ntawm lawv tsuas yog pab txhawb kev nthuav tawm ntawm kev tiv thaiv cov hnoos qeev. Cov no yog cov tshuaj raws li cov licorice hauv paus (Flacarbin granules, kev rho tawm, kua txiv licorice, Likvirshpon ntsiav tshuaj) thiab calamus rhizomes (Vikalin thiab Vikair npaj). Lwm tus ntxiv cov khoom tiv thaiv ntawm hnoos qeev. Qhov no yog lub decoction los ntawm cov hauv paus hniav ntawm elecampane (Alantoin ntsiav tshuaj), kua txiv ntawm cov zaub qhwv nyoos.

Nrog rau qhov mob txhab tob tob, tso ntshav tawm sai, siv tshuaj kho mob rau lub plab yog qhia - cov neeg ua yeeb yaj kiab (cov tshuaj "Ulkogant", "Carafate", "Ke").

Kev npaj ua Bismuth

Cov tshuaj kho mob rau qhov txhab ua txhab raws li lub cev no muaj qhov sib xyaw ua ke. Lawv envelop lub flaws ntawm mucosa, tsim kom muaj kev tiv thaiv kev tiv thaiv. Ntxiv rau, lawv inhibit qhov kev ua ntawm cov kua qaub ntawm lub plab, tua cov microbes uas ua rau mob kiav txhab (Helicobacter pylori). Cov tshuaj siv ntau hom yog De-nol.

Hauv kev xyaum kho mob, muaj kev kuaj mob uas xav tau kev tsuj tawm ntawm qee lub cev ua haujlwm: lub zais pa ntawm cov enzymes, cov tshuaj hormones. Qhov no yog qhov tsim nyog rau tag nrho lub neej lossis thaum phais kev ua haujlwm rau kev rov qab zoo nyob rau lub sijhawm postoperative. Xws li cov chaw kuaj mob muaj xws li acromegaly, mob qog nqaij hlav, tsim nyob rau hauv endocrine system, kev tsis yooj yim ntawm cov qauv kev kho mob (kev kho hluav taws xob, kev phais mob).

Cov lus qhia rau kev siv Octreotide

Cov tshuaj no hais txog cov tshuaj tiv thaiv kab mob sib xws los yog cov keeb ntawm cov tshuaj hormones ntawm tib neeg lub cev. Cov tshuaj nquag hloov hloov somatostatin, nws muaj tib qhov zoo ntawm pharmacological, tab sis muaj cov nyhuv ntev dua. Cov tshuaj Octreotide inhibits kev tsim tawm ntawm kev loj hlob hormone, insulin, serotonin, glucagon, gastrin, uas ntau dhau lawm vim yog pathology lossis tom qab noj mov.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj yog cov neeg sawv cev hauv kev tiv thaiv kev tsim cov tshuaj hormones, yog li ntawd, ib qho kev hloov ywj siab hauv kev noj tshuaj lossis tshuaj tsis muaj kws kho mob los ntawm kws kho mob tsis tso cai. Qhov tsis tsim nyog ntawm kev siv cov tshuaj ua rau txoj kev loj hlob ntawm cov kabmob tseem ceeb, lossis rau kev tsim cov tshiab vim tias tsis txaus cov tshuaj hormones. Cov koob tshuaj thiab daim ntawv ntawm kev txhaj tshuaj yog kho nkaus xwb coj mus rau hauv qhov kev kuaj mob thiab tus mob ntawm qee tus neeg mob. Cov Ntawv Pov Tseg thiab Daim Ntawv Ntev yog muab tshwj rau cov leeg khov.

Kev siv tshuaj rau cov qauv rau ntau yam kabmob muaj raws li hauv qab no:

octreotide rau pancreatitis (mob siab) - 100 mcg 3 zaug hauv ib hnub rau 5 hnub subcutaneously (s / c) (nws muaj peev xwm nce qhov koob tshuaj rau 1200 mcg / hnub los ntawm kev txhaj tshuaj rau hauv txoj hlab ntshav (iv)),
nres qhov mob txhab ntshav - 25-50 mcg / teev iv rau 5 hnub,
cheem venous (varicose) los ntshav txoj hlab pas - 25-50 mcg / teev iv rau 5 hnub,
prophylactic koob tshuaj thaum lub sijhawm ua haujlwm - 100-200 mcg s / c 1-2 teev ua ntej kev phais mob, 100-200 s / c 3 zaug / hnub - tom qab phais mob 5-7 hnub,
acromegaly lossis gastroenteropancreotic hlav - 50-100 mcg 1-2 hno txhua hnub.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj maj mam txo qis qhov nqus ntawm cimetidine thiab txo qhov nqus ntawm cyclosporine. Nyob rau hauv cov ntsiab lus nrog diuretics, beta-blockers, insulin, qhov ncauj tshuaj hypoglycemic, blockers ntawm "qeeb" calcium channel, yuav tsum tau hloov kho koob tshuaj. Lub bioavailability ntawm bromocriptine yog nce zuj zus. Cov tshuaj uas raug rau metabolization ntawm cov enzymes ntawm cytochrome P450 system tau sau tseg nyob rau hauv kev saib xyuas nruj ntawm tus kws tshaj lij.

Noj ntau dhau

Thaum kho, kev saib xyuas ntau dhau lawm tuaj yeem pom hauv qhov kev mob tshwm sim: xeev siab, liab ntsej muag, zoo li tsis muaj plab, txo lub plawv dhia, mob plawv. Yog tias muaj cov cim no tshwm sim, nres kev kho mob thiab sab laj nrog kws kho mob.

Cia rau cov neeg mob

Khaws cov tshuaj rau hauv lub tub yees txias ntawm + 2 ... + 8ºC.Tsis txhob khov cov tshuaj. Txav deb ntawm tshav ntuj.

Hnub tas sij hawm

Lub sijhawm ntawm cia - 3 xyoos.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj tseem ceeb yog okreotide. Daim ntawv tso tawm yog ampoules nrog kev daws rau subcutaneous thiab kev tso dej khov thiab microspheres rau kev tsim khoom ntawm kev ncua rau kev tswj hwm intramuscularly.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub thiab pub niam mis, cov tshuaj tsis raug txwv.

Siv rau thaum yau

Tsis muaj ntaub ntawv hais txog kev siv cov tshuaj rau menyuam yaus.

Cov Cai Siv Tshuaj So

Hauv cov khw muag tshuaj, cov tshuaj yog muag los ntawm cov tshuaj noj.

Hauv qab plab ntu yog to taub qhov tsim ntawm ib qho laj kab hauv lub cev ntawm phab ntsa ntawm ib qho khoom nruab nrog. Ntxiv mus, cov txheej txheem tsis zoo cuam tshuam feem ntau ntawm cov mucous membrane. Ua ntej koj xaiv cov tshuaj rau cov mob rwj, koj yuav tsum paub me ntsis txog kab mob.

Ntau hom mob txhab

Raws li qhov tob ntawm lub qhov txhab, mob txhab yog tsis meej, cuam tshuam tsuas yog cov leeg ntawm lub cev, thiab tob, ntes cov leeg thiab cov leeg nqaij ntawm lub plab. Nrog rau los ntawm kev puas tsuaj ntawm phab ntsa ntawm cov khoom hauv nruab nrog, lawv hais txog nws cov perforation, lossis perforation. Hauv qhov no, cov ntsiab lus ntawm lub plab yog hliv rau hauv qhov mob plab. Nrog lub caij nyoog ntev ntawm tus kab mob, cov neeg nyob sib ze tuaj yeem lo rau ntawm phab ntsa ntawm qhov khoom nruab nrog los ntawm sab nraud, thiab cov nyhuv mob tshwm tuaj yeem kis mus rau lawv. Nyob rau hauv qhov xwm txheej zoo sib xws, peb tab tom tham txog kev nkag mus, nkag mus rau qhov mob txhab.

Yam tshuaj dab tsi kho tau lub plab mob

Calcium carbonate yog ib qho tshuaj muaj zog dua li cov tshuaj tau piav saum toj no, tab sis nws muaj cov nyhuv zoo sib xws. Cov tshuaj noj nrog siv ntev ntev ua rau cem quav thiab zaum ob.

Lub plab zais pa blockers

Pharmacological pawg secretion blockers

Cov tshuaj platifillin, nrog rau cov metacin, cais tawm los ntawm nplooj snowdrop, muaj cov nyhuv tsawg dua. Lawv daws cov mob plab zom mov thiab maj mam txo qis nws lub zais.

Gastrocepin lossis pirenzepine pab tiv thaiv kom rov zoo thiab kho qhov mob. Qhov khoom siv no ua tau zoo, ntev ntev txo kev ua kom muaj kua qaub, muaj kev cuam tshuam zoo rau lub plab zom mov.

Lub plab zom mov: kho nrog cytoprotective siv yeeb siv tshuaj

Nrog rau qhov mob txhab tob tob, tso ntshav tawm sai, siv tshuaj kho mob rau lub plab yog qhia - cov neeg ua yeeb yaj kiab (cov tshuaj "Ulkogant", "Carafate", "Ke").

Kev npaj ua Bismuth

Cov lus qhia rau kev siv Octreotide

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Octreotide muaj tshwj xeeb rau hauv kev daws teeb meem rau kev tswj hwm intramuscular thiab subcutaneous. Qhov ntim ntawm ampoules yog 1 thiab 5 ml. Qhov ntau npaum li cas nyob hauv lub ntsiab ntawm cov tshuaj nquag rau 1 ml ntawm kev daws: 50, 100, 300, 600 mcg. Cov kua ua rau tsis muaj xim thiab ntxhiab. Cov tshuaj no tau muab kaw hauv cov thawv contour cardboard. Octreotide-Depot thiab Octreotide-Ntev yog cov tshuaj lyophilized rau cov roj ntsha (nyob rau hauv qee yam qauv, nias rau ib ntsiav tshuaj) ua kom tiav nrog cov kuab tshuaj, rov ua kom raug ncua, tshwj xeeb koob txhaj tshuaj thiab koob txhaj tshuaj intramuscular.

Tshuaj yeeb hauv kev npaj

Dej rau kev txhaj tshuaj

Octreotide-Depot muaj cov ntawv luam ntawm dl-lactic thiab glycolic acids, polysorbate-80, dej rau txhaj, D-mannitol, sodium ntsev ntawm carboxymethyl cellulose. Rau cov tshuaj Octreotide-Ntev, carmellose sodium, D-mannitol yog siv. Qhov sib txawv ntawm peb daim ntawv ntawm cov tshuaj yog:

hauv kev nrawm nrawm,
lub sijhawm mus nrhiav kev kho tshuaj ntawm cov tshuaj nquag hauv lub cev,
kev taw qhia ntawm kev cuam tshuam.

Pharmacodynamics thiab pharmacokinetics

Cov tshuaj yog tsim los tswj kev zais cia cov tshuaj hormones uas tsim tawm ntau dhau los ntawm tus neeg mob lub cev vim yog pathologies thiab tom qab noj mov. Qhov no siv rau glucagon, insulin, gastrin, serotonin, insulin. Octreotide txo qis ntau lawm kev loj hlob hormone tshwm sim los ntawm kev tawm dag lub cev ntau dhau, arginine, lossis insulin hypoglycemia. Thyrotropin secretion tseem tseem suppressed.

Cov tshuaj yog siv los txo cov kev pheej hmoo ntawm kev tom qab ua haujlwm tom qab kev phais mob ntawm kev txiav (txiav pob txha, fistula, mob leeg mob tom qab kev phais mob, sepsis, qog ntshav). Octreotide yog siv, ua ke nrog lwm yam tshuaj, txhawm rau kom tsis txhob los ntshav thiab nws rov qab los ntawm cov leeg ntshav ntawm lub plab thiab lub plab zom mov hauv cov neeg mob uas ua rau mob qog.

Nrog rau kev coj ua subcutaneous, cov tshuaj yog nqus sai sai li sai tau: qhov siab tshaj plaws ntawm cov tshuaj nquag tau mus txog tom qab 30 feeb. Cov tshuaj khi rau cov ntshav plasma protein li ntawm 65%. Cov tshuaj no tau tawm ntawm lub cev tom qab 100 feeb nrog kev tswj hwm subcutaneous. Nrog kev txhaj tshuaj rau hauv lub cev, kev tso tawm octreotide los ntawm lub cev yog nqa hauv 2 qib: tom qab 10 thiab 90 feeb. Feem ntau ntawm cov tshuaj tau dhau los ntawm txoj hnyuv, 32% yog tshem tawm los ntawm lub raum tsis hloov.

Kev ntsuas rau kev siv Octreotide

Cov tshuaj yog tsom rau kev txwv tsis pub muaj kev cia siab ntawm cov tshuaj hormones nrog cov kab mob loj. Tsis tas li ntawd, cov tshuaj yeeb yog siv los tiv thaiv kev mob tom qab ntawm lub plab. Cov cuab yeej raug pom zoo rau kev siv ua ke nrog qee hom kev kho mob (piv txwv, endoscopic sclerotherapy). Cov lus qhia tseem ceeb ntawm kev siv Octreotide:

mob leeg txhaj leeg
Tso tseg los ntshav nrog mob peptic rwj ntawm duodenum thiab lub plab,
kev tiv thaiv thiab nres ntawm cov leeg ntshav nrog rau daim siab ua mob rau lub siab,
kev kho thiab kev tiv thaiv ntawm cov teeb meem plab hauv plab tom qab kev phais,
acromegaly, nrog qhov tsis muaj txiaj ntsig ntawm dopamine agonists, tsis muaj peev xwm los ua kev phais mob, kev kho hluav taws xob,
lub plab endocrine mob qog ntawm lub plab hnyuv plab zom mov plab,
glucagonoma
mob ncauj plab
mob ntshav qab zib (refractory) tiv thaiv kab mob hauv cov neeg mob AIDS.

Tsuas tshuaj thiab tswj hwm

Kev siv tshuaj rau cov qauv rau ntau yam kabmob muaj raws li hauv qab no:

octreotide rau pancreatitis (mob siab) - 100 mcg 3 zaug hauv ib hnub rau 5 hnub subcutaneously (s / c) (nws muaj peev xwm nce qhov koob tshuaj rau 1200 mcg / hnub los ntawm kev txhaj tshuaj rau hauv txoj hlab ntshav (iv)),
nres qhov mob txhab ntshav - 25-50 mcg / teev iv rau 5 hnub,
cheem venous (varicose) los ntshav txoj hlab pas - 25-50 mcg / teev iv rau 5 hnub,
prophylactic koob tshuaj thaum lub sijhawm ua haujlwm - 100-200 mcg s / c 1-2 teev ua ntej kev phais mob, 100-200 s / c 3 zaug / hnub - tom qab phais mob 5-7 hnub,
acromegaly lossis gastroenteropancreotic hlav - 50-100 mcg 1-2 hno txhua hnub.

Yeeb tshuaj sib cuam tshuam

Sab sij huam

Lub sijhawm ntev siv ntawm cov tshuaj provokes tsim ntawm pob zeb nyob hauv lub gallbladder. Ntxiv nrog rau kev fab tshuaj thiab alopecia thaum siv tshuaj, ntau yam kev phiv tuaj yeem tshwm sim. Lawv cov tsos ncaj qha nyob ntawm qhov mob hnyav, tus mob ntawm tus neeg mob, thiab kev sib cuam tshuam tshuaj. Kev saib xyuas yuav tsum tau nqis tes rau kev noj haus vim yog qhov hloov pauv ntawm kev zais ntawm insulin thiab lwm yam tshuaj hormones. Cov tshuaj phiv:

kev tsis nco qab
xeev siab, ntuav, tsam plab, mob plab, raws plab, tiv thaiv qog, mob ib ce,
hnyuv ob leeg (muaj tsawg)
Kab mob siab tsis muaj cholestasis,
arrhythmia,
bradycardia
hyperbilirubinemia,
hyperglycemia
tsis hnov lus qabzib zoo,
kev txhim kho ntawm kev pheej hmoo hypoglycemia,
khaus, hlawv, liab, o ntawm daim tawv nqaij lossis cov leeg ntawm qhov chaw txhaj tshuaj.

Noj ntau dhau

Kev siv cov tshuaj Octreotide nyob rau hauv ntau dhau qhov tseeb ua rau lub ntsej muag txo qis qis rau lub plawv ntev, qhov hnov ntawm ntshav khiav mus rau lub taub hau thiab lub ntsej muag. Cais, kev noj ntau dhau tuaj yeem tshwm sim nws tus kheej hauv kev ua txhaum ntawm txoj haujlwm ntawm lub plab zom mov: xeev siab, raws plab, zoo nkaus li lub plab khoob (kev tshaib plab sai sai), mob leeg. Tus mob yog kho tus yam ntxwv, tsis tas yuav tsum tu ncua kev kho mob (tshwj tsis yog mob nyav).

Cov Lus Qhia Txog Octreotide

Cov tshuaj pauv hloov tshuaj tau raug muab rau kev tsis txaus siab rau tus neeg saib xyuas lub hauv paus lossis nws qhov nkag tsis tau. Analogs kuj tseem muaj nyob ntawm daim ntawv yuav tshuaj, yog li ntawm kev siv lawv txoj kev ywj pheej siv Octreotide yog tsis yooj yim sua. Nws yuav tsum nco ntsoov tias qhov hloov pauv ntawm qhov kev kho mob yog coj los ntawm tus kws kho mob tshwj xeeb rau cov hauv paus ntawm tus neeg mob lub cev ib leeg rau txoj kev kho. Lub analogues lub ntsiab ntawm Octreotide:

cov tshuaj Sandostatin yog hmoov hmoov rau kev tsim cov kev daws rau iv thiab SC txhaj tshuaj, cov tshuaj nquag yog octreotide, cov nyhuv ntawm lub cev yog zoo ib yam,
Somatostatin - cov tshuaj raws li cov tshuaj ntshiab uas txwv tsis pub tsim cov tshuaj hormones kev loj hlob, ib qho inhibitor ntawm serotonin, qee yam peptides,
Diferelin, ib qho analogue rau subcutaneous tswj hwm raws li triptorelin acetate, yog siv rau hauv kev kho mob ntawm poj niam tsis muaj zog, IVF rau kev txwv cov tshuaj hormones thiab tshuaj zoo ib yam thaum tsis tuaj yeem siv octreotide,
Sermorelin siv tshuaj - siv los kuaj kev ua lub cev tsis ua haujlwm thiab kev muaj peev xwm ntawm kev loj hlob cov tshuaj hormones (kuaj xyuas seb puas muaj peev xwm ua rau cov tshuaj hormones tsis txaus nyob rau hauv cov menyuam yaus tsis tuaj yeem).

Vim tias qhov tshwj xeeb ntawm kev tsim tawm, cov tshuaj muaj nqis (cov qauv siv tshuaj tsis sib txawv ntau ntawm cov nqi thiab muaj lawv tus kheej tshwj xeeb ntawm kev siv). Tus nqi nruab nrab hauv cov khw muag tshuaj hauv Moscow yog 1300 rubles. Tus nqi sib txawv raws li hom tshuaj, nws cov concentration, lub teb chaws kev tsim khoom. Hauv cov cheeb tsam, cov khoom lag luam qee zaum raug nqi 15-30% kim dua vim nws tsawg qhov xav tau. Tus nqi nruab nrab hauv Moscow thiab thaj av peev: