Gentamicin sulfate: cov lus qhia rau kev siv, analogues thiab tshuaj xyuas

Ntau txoj kev sib kis thiab tshuaj hauv lub cev tsis tuaj yeem ua yam tsis siv tshuaj tua kab mob. Ib pawg ntawm cov tshuaj no tua cov teeb meem me me thiab kab mob. Ib qho ntawm cov tshuaj tiv thaiv kab mob uas paub zoo yog Gentamicin Sulfate. Nws suav hais tias yog tshuaj tua kab mob nrog kev siv dav thiab siv los kho tib neeg thiab tsiaj.

Lub Npe Tsis Muaj Npe International

Lub npe thoob ntiaj teb nonproprietary tshuaj yog Gentamicin (hauv Latin - Gentamycin lossis Gentamycinum).

Gentamicin Sulfate yog ib hom tshuaj tua kab mob ntau yam.

Gentamicin nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj yog raug muab cov anatomical-tshuaj-tshuaj (ATX) code J01GB03. Tsab ntawv J txhais tau tias cov tshuaj yog tshuaj tua kabmob thiab siv tshuaj tua kab mob thiab siv rau kev kho mob hauv nruab nrab, cov tsiaj ntawv G thiab B txhais tau tias nws yog pawg ntawm aminoglycosides.

Qhov ATX code rau cov qhov muag pom yog S01AA11. Tsab ntawv S txhais tau hais tias cov tshuaj no yog siv rau kev kho mob ntawm lub plab hnyuv siab ntsws, thiab cov tsiaj ntawv AA qhia tau tias cov tshuaj no yog rau siv tshuaj pleev thiab cuam tshuam rau cov metabolism.

Qhov ATX code ntawm tshuaj pleev Gentamicin yog D06AX07. Tsab ntawv D txhais tau tias cov tshuaj yog npaj rau kev siv hauv tshuaj dermatology, thiab cov tsiaj ntawv AX - tias nws yog tshuaj tua kab mob hauv siab.

Tso cov ntaub ntawv thiab cov nyob ua ke

Gentamicin muaj 4 daim ntawv tso tawm:

txhaj tshuaj siv
qhov muag dauv
tshuaj pleev
aerosol.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj.
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm lub qhov muag.Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj pleev.

Lub hauv paus ua haujlwm tseem ceeb hauv txhua 4 daim ntawv yog gentamicin sulfate. Cov tshuaj sib tov ntawm cov tshuaj txhaj suav nrog cov ntu ua ke:

sodium metabisulfite
disodium ntsev
dej rau kev txhaj tshuaj.

Cov tshuaj tau tawm hauv 2 ml ampoules, uas tau ntim hauv 5 pcs. hauv cov hlwv pob. Ib pob muaj 1 lossis 2 pob (5 lossis 10 ampoules) thiab cov lus qhia rau siv.

Ntu ntu ntawm cov tee qhov muag yog:

disodium ntsev
sodium tshuaj dawb
dej rau kev txhaj tshuaj.

Kev daws tau ntim rau hauv 1 ml hauv dropper cov hlab (1 ml muaj 3 mg ntawm cov tshuaj nquag). 1 pob tuaj yeem ntim 1 lossis 2 pob roj hmab.

Cov neeg tau txais txiaj ntsig ntawm cov tshuaj pleev yog cov paraffins:

Cov tshuaj raug muag hauv cov raj ntawm 15 mg.

Gentamicin nyob rau hauv daim ntawv ntawm aerosol ua ib ntu pabcuam muaj cov khoom siv aerosol ua npuas ncauj thiab tau ntim rau hauv 140 g hauv tshwj xeeb aerosol fwj nruab nrog tshuaj tsuag.

Pharmacological kev txiav txim

Gentamicin yog cov tshuaj tua kab mob uas siv los kho tshuaj (tawv nqaij) thiab muaj kabmob sab hauv. Cov tshuaj tua cov kab mob me, rhuav tshem lawv txoj haujlwm cuam tshuam. Cov tshuaj no tawm tsam cov kab mob xws li:

staphylococci,
streptococci (ib co leeg),
Ntxaug Yaj
salmonella
Pseudomonas aeruginosa,
enterobacter
Klebsiella
protea.

Cov tshuaj yog nquag tiv thaiv cov kab mob pawg xws li salmonella.
Cov tshuaj yog nquag tiv thaiv cov kab mob xws li streptococci.
Cov tshuaj yog nquag tiv thaiv cov kab mob pawg xws li Klebsiella.
Cov tshuaj yog nquag tawm tsam cov pawg kab mob xws li Shigella.
Cov tshuaj yog nquag tiv thaiv cov kab mob pab pawg xws li Pseudomonas aeruginosa.
Cov tshuaj yog nquag tiv thaiv cov kab mob xws li staphylococci.

Cov tshuaj tsis ua haujlwm:

treponema (tus neeg sawv cev ntawm tus mob syphilis),
on neiseria (mob rau daim npluag paj hlwb),
ntawm cov kab mob anaerobic,
rau kab mob, fungi thiab protozoa.

Cov Tshuaj Pharmacokinetics

Kev muaj txiaj ntsig zoo tshaj plaws ntawm lub cev yog muab los ntawm kev txhaj tshuaj rau cov leeg thiab intramuscular. Nrog kev txhaj tshuaj intramuscular, qhov siab tshaj plaws ntshav plasma concentration tom qab 30-60 feeb. Cov tshuaj yog txiav txim nyob rau hauv cov ntshav rau 12 teev. Ntxiv rau ntshav ntshav, Gentamicin nkag mus sai thiab tau txhais tau zoo hauv cov ntaub so ntswg ntawm lub ntsws, ob lub raum thiab mob siab, lub cev, ntxiv rau hauv hnoos qeev thiab kua dej xws li:

Qhov qis tshaj plaws ntawm cov tshuaj yog pom hauv cov kua tsib thiab cerebrospinal kua.

Cov tshuaj tsis tuaj yeem tsim nyob hauv lub cev: ntau dua 90% ntawm cov tshuaj siv tawm hauv lub raum. Tus nqi ntawm qhov ua tau zoo yog nce raws tus neeg mob lub hnub nyoog thiab kev ua kom muaj peev xwm tsim cov pa dej. Hauv cov neeg mob cov neeg laus uas muaj lub raum zoo, lub sijhawm ib nrab ntawm kev siv tshuaj yog 2-3 teev, hauv cov menyuam hnub nyoog 1 lub lis piam mus rau 6 hlis - 3-3,5 teev, nce txog 1 lub lis piam - 5.5 teev, yog tias tus me nyuam hnyav dua 2 kg , thiab ntau dua 8 teev yog tias nws qhov hnyav tsawg dua 2 kg.

Ib nrab-lub neej tuaj yeem nrawm nrog:

anemia
siab kub
kub nyhiab heev.

Ib nrab-lub neej ntawm cov tshuaj muaj peev xwm yuav nrawm nrog anemia.
Ib nrab-lub neej ntawm cov tshuaj yuav tau nrawm thaum nce mus txog qhov kub thiab txias.
Ib nrab-lub neej ntawm cov tshuaj muaj peev xwm yuav ua kom nrawm nrog kub hnyav.

Nrog rau cov kab mob hauv lub raum, ib nrab ntawm lub neej ntawm Gentamicin yog lengthened thiab nws txoj kev tshem tawm tej zaum yuav ua tsis tiav, uas yuav ua rau kev sib txuam ntawm cov tshuaj hauv lub cev thiab tshwm sim ntawm kev siv ntau dhau.

Nws siv rau dab tsi?

Cov tshuaj yog tawm rau kis kab mob thiab kis mob:

Mob txeeb zis. Xws li:
- pyelonephritis,
- txoj hlab zis
- cystitis
- prostatitis.
Kev nqus tau pa tsawg. Xws li:
- pleurisy
- mob ntsws
- mob ntsws
- empyema
- lub ntsws ua qog.
Plab plab. Xws li:
- mob peritonitis
- cholangitis
- mob hnoos qhuav.
Cov pob txha thiab pob qij txha.
Daim tawv nqaij integument. Xws li:
- trophic rwj
- hlawv
- mob ntsws,
- seborrheic dermatitis,
- pob txuv
- paronychia
- txiv yawg,
- mob caj dab.
Lub qhov muag. Xws li:
- pom mob pob txha
- blepharitis
- keratitis.
Nruab nrab hauv lub paj hlwb, nrog rau cov mob hlwb thiab vermiculitis.

Cov tshuaj yog tawm rau kis thiab kis mob ntawm kev sib koom tes thiab pob txha.
Cov tshuaj yog kws kho mob rau qhov mob txha cajqwm.
Cov tshuaj yog kws kho rau trophic rwj.
Cov tshuaj yog tshuaj rau pleurisy.
Cov tshuaj yog tshuaj rau tus mob peritonitis.
Cov tshuaj yog kws kho rau pyelonephritis.
Cov tshuaj tau sau tseg rau cov mob meningitis.

Gentamicin tseem tseem siv rau hauv cov mob sepsis los ntawm kev phais mob thiab kab mob septicemia.

Cov Yuav Tsum Tau Ua

Cov tshuaj tsis tau sau tseg yog tus neeg mob:

tsis zam cov tshuaj tua kab mob ntawm pawg antiglycoside lossis lwm cov khoom siv uas ua rau cov tshuaj,

suffers los ntawm neuritis ntawm auditory paj,
mob azotemia, uremia,
muaj mob raum lossis siab mob hnyav,
xeeb tub
yog ib tug niam tsev mob siab
mob nrog myasthenia
muaj mob los ntawm tus kab mob Parkinson,
muaj cov kab mob ntawm cov khoom siv vestibular (kiv taub hau, tinnitus),
nyob rau hauv 3 xyoos.

Nrog saib xyuas

Cov tshuaj no yog siv nrog kev ceev faj, yog tias muaj keeb kwm muaj qhov qhia txog qhov ua rau fab tshuaj tsis haum, thiab tseem yog tias tus neeg mob muaj mob:

Cov tshuaj tau noj nrog ceev faj heev yog tias tus neeg mob mob tus kab mob botulism.
Cov tshuaj yog noj nrog ceev faj heev yog tias tus neeg mob mob nrog hypocalcemia.
Cov tshuaj yog noj nrog ceev faj heev yog tias tus neeg mob mob lub cev qhuav dej.

Yuav ua li cas noj gentamicin sulfate?

Rau cov neeg mob uas muaj hnub nyoog 14 xyoos nrog cov kab mob ntawm lub tso zis, txoj kev kho mob yog 0.4 mg thiab muab 2-3 zaug ib hnub intramuscularly, nrog cov mob hnyav thiab sepsis, cov tshuaj tau txhaj 3-4 zaug hauv ib hnub, 0.8-1 mg. Qhov kev siv ntau tshaj yuav tsum tsis pub tshaj 5 mg ib hnub. Lub sijhawm tiv thaiv yog 7-10 hnub. Hauv cov xwm txheej loj, hauv 2-3 hnub dhau los, Gentamicin raug muab tshuaj rau hauv qhov quav, tom qab ntawd tus neeg mob hloov mus rau kev txhaj tshuaj intramuscular.

Rau kev tswj hwm kev siv tshuaj, tsuas yog cov tshuaj tiv thaiv tau npaj hauv ampoules yog siv; rau kev txhaj tshuaj rau cov leeg, cov tshuaj tau npaj ua ntej kev tswj hwm, yaj lub hmoov nrog dej rau kev txhaj tshuaj.

Gentamicin tuaj yeem raug coj los ua kev nqus tshuaj los kho kab mob ua pa.

Purulent o ntawm daim tawv nqaij, cov hauv paus plaub hau, mob ntsws thiab lwm yam kab mob ntawm daim tawv qhuav yog kho nrog tshuaj pleev. Ua ntej, cov cheeb tsam cuam tshuam tau kho nrog Furatsilin txoj kev daws teeb meem kom tshem tawm cov paug paug thiab cov tshuaj tua tuag, thiab tom qab ntawd txheej txheej ntawm cov tshuaj pleev pleev tau thov 2-3 zaug hauv ib hnub rau 7-10 hnub (ntaub qhwv tuaj yeem siv). Cov koob tshuaj pleev rau txhua hnub rau cov neeg laus yuav tsum tsis pub ntau tshaj 200 mg.

Cov kab mob qhov muag tau kho nrog tee, sau lawv rau hauv hnab looj tes sib luag 3-4 zaug hauv ib hnub.
Purulent o ntawm daim tawv nqaij, cov hauv paus plaub hau, mob ntsws thiab lwm yam kab mob ntawm daim tawv qhuav yog kho nrog tshuaj pleev.
Gentamicin tuaj yeem raug coj los ua kev nqus tshuaj los kho kab mob ua pa.
Txog kev txhaj tshuaj intramuscular, cov tshuaj tau npaj ua ntej kev tswj hwm, yaj lub hmoov nrog dej rau kev txhaj tshuaj.
Rau kev tswj hwm intravenous, tsuas yog npaj-qhov tshuaj nyob rau hauv ampoules yog siv.

Aerosol yog siv los kho cov kab mob ntawm daim tawv nqaij, tab sis cov txheej txheem ntawm kev siv yog tib yam li rau cov tshuaj pleev. Aerosol yuav tsum tau muab tshuaj los tiv thaiv los ntawm ib nrug deb txog 10 cm los ntawm saum npoo ntawm cov tawv nqaij.

Cov kab mob qhov muag tau kho nrog tee, sau lawv rau hauv hnab looj tes sib luag 3-4 zaug hauv ib hnub.

Kev phiv los ntawm Gentamicin Sulfate

Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj thiab tuaj yeem tshwm sim hauv daim ntawv ntawm:

ua tsaug zog, kiv taub hau, mob taub hau,
tsis qab los noj mov, nce dej salivation, xeev siab, ntuav, poob phaus,
mob leeg, sib ntswg, cramps, loog, mob caj dab,
muaj kev cuam tshuam los ntawm cov ntsaws tsho khuam,
hnov lus
lub raum tsis ua hauj lwm
kev tsis txaus siab ntawm cov kab mob ntawm txoj hlab zis (oliguria, microhematuria, proteinuria),
urticaria, ua npaws, khaus, tawv nqaij ua pob,
txo cov qe ntshav dawb, platelet, potassium, magnesium thiab calcium hauv cov ntshav,
txhawb kev kuaj ntshav siab kom nce siab.

Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj tshwm sim thiab tuaj yeem tshwm sim rau daim ntawv chua leeg.Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj tshwm sim thiab tuaj yeem tshwm sim hauv kev hnov lus.
Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj thiab tuaj yeem tshwm sim li oliguria.
Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj thiab tuaj yeem tshwm sim rau hauv txoj kev tsaug zog.
Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj thiab tuaj yeem tshwm sim yog lub raum tsis ua haujlwm.Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin tsis tshua muaj tshwm sim thiab tuaj yeem tshwm sim hauv daim ntawv ntawm urticaria.
Kev phiv tshuaj uas tshwm sim los ntawm kev noj cov tshuaj Gentamicin yog qhov tsis tshua muaj thiab tuaj yeem tshwm sim rau hauv txoj kev uas tsis xav noj.

Tsis tshua muaj neeg ua tau:

mob intramuscular,
phlebitis lossis thrombophlebitis hauv kev saib xyuas ntawm kev tso tshuaj,
tubular necrosis,
kev tsim kho superinfection,
anaphylactic poob siab.

Cov lus qhia tshwj xeeb

Thaum kho nrog Gentamicin, nws yog ib qhov tsim nyog los soj qab saib lub luag haujlwm ntawm lub raum, vestibular thiab pob ntseg hnov.
Nws yog ib qho tsim nyog yuav tsum soj ntsuam qib theem ntawm poov tshuaj, magnesium thiab calcium hauv cov ntshav.
Rau cov neeg mob raum tsis ua hauj lwm zoo, kev tswj hwm tus kheej muaj tsim nyog.
Ib tug neeg mob uas tau mob hnyav los yog mob hnyav ntawm lub chaw tso zis (nyob rau theem ntawm exacerbation) yuav tsum siv dej ntau dua thaum kho nrog Gentamicin.
Kev siv dej cawv thiab cawv muaj yees thaum lub sij hawm kho nrog Gentamicin yog txwv tsis pub.
Vim hais tias cov tshuaj ua rau txo qis qis hauv lub cev, kiv taub hau, txo qis ntawm qhov muag pom, nws yog qhov yuav tsum tso tseg cov tsav tsheb thaum lub sijhawm kho.

Kev siv dej cawv thiab cawv muaj yees thaum lub sij hawm kho nrog Gentamicin yog txwv tsis pub.
Thaum kho nrog Gentamicin, nws yog qhov yuav tsum tau soj ntsuam txhua theem ntawm cov poov tshuaj, magnesium thiab calcium hauv cov ntshav.
Vim hais tias cov tshuaj ua rau poob qis hauv kev mloog zoo, nws yog ib qho tsim nyog yuav tsum tso tseg kev tsav tsheb rau lub sijhawm kho.
Ib tug neeg mob uas tau mob hnyav los yog mob hnyav ntawm lub chaw tso zis (nyob rau theem ntawm exacerbation) yuav tsum siv dej ntau dua thaum kho nrog Gentamicin.

Siv rau lub sijhawm qub

Gentamicin yuav tsum siv nrog ceev faj hauv cov neeg laus. Cov tshuaj muaj qhov ua rau lub ntsej muag tsis zoo thiab ua rau lub ntsej muag, lub raum kev ua haujlwm, thiab hauv cov neeg laus, cov kab ke no, ua rau muaj kev hloov pauv hauv hnub nyoog, feem ntau twb ua haujlwm nrog tsis meej. Yog tias kev txiav txim siab txiav txim siab tawm tshuaj, tom qab ntawd thaum kho mob thiab qee lub sijhawm tom qab ua tiav, tus neeg mob yuav tsum soj ntsuam kom tshem tawm creatinine thiab pom los ntawm tus kws kho mob otolaryngologist.

Khaws cov tshuaj Gentamicin Sulfate rau Cov Menyuam

Rau cov menyuam yaus hnub nyoog qis dua 14 xyoos, kev tswj hwm ntawm cov tshuaj yog raug txiav txim tsuas yog nyob rau kis tseem ceeb xav tau. Koob tshuaj ib zaug yog xam raws lub hnub nyoog thiab qhov hnyav ntawm tus menyuam: rau cov menyuam hnub nyoog 6 txog 14 xyoos - 3 mg / kg, los ntawm 1 txog 6 - 1.5 mg / kg, tsawg dua 1 xyoos - 1.5-2 mg / kg. Qhov koob tshuaj ntau tshaj plaws rau txhua tus neeg mob hnub nyoog qis dua 14 xyoos yuav tsum tsis pub tshaj 5 mg / kg. Cov tshuaj yog muab 2-3 zaug ib hnub rau 7-10 hnub.

Kho cov tawv nqaij hauv qhov muag lossis tawv muag nrog aerosol, tshuaj pleev, lossis tshuaj pleev qhov muag yog qhov muaj mob tsawg dua thiab tuaj yeem kho rau cov neeg mob hnub nyoog qis dua 14 xyoos. Cov txheej txheem kho zoo tib yam li rau cov neeg laus. Kev noj tshuaj txhua hnub ntawm cov tshuaj pleev yuav tsum tsis pub ntau tshaj 60 mg.

Siv thaum cev xeeb tub thiab lactation

Cov tshuaj tau yooj yim kis tawm ntawm cov txiaj ntsig thiab mus rau niam mis, yog li ntawd, cov tshuaj tiv thaiv kab mob tau txwv tsis pub rau cov poj niam cev xeeb tub thiab lactating. Ib zaug hauv tus menyuam lub cev, cov tshuaj ua rau ua txhaum lub plab zom mov thiab tuaj yeem ua rau lub cim ntawm ototoxicity. Ib qho kev zam yog qhov xwm txheej uas yuav ua rau muaj txiaj ntsig zoo rau leej niam yuav dhau qhov kev phom sij rau tus menyuam.

Cov tshuaj yoojyim nkag rau hauv lub tsho me nyuam, yog li ntawd, cov poj niam cev xeeb tub tsis pub noj tshuaj tiv thaiv.
Cov tshuaj yooj yim kis mus rau niam mis, yog li kev siv tshuaj tiv thaiv kab mob yog txwv rau cov poj niam uas pub niam mis.
Rau cov menyuam yaus hnub nyoog qis dua 14 xyoos, kev tswj hwm ntawm cov tshuaj yog raug txiav txim tsuas yog nyob rau kis tseem ceeb xav tau.

Kev noj tshuaj ntawm Gentamicin Sulfate

Kev siv tshuaj ntau dhau tsuas yog tshwm sim los ntawm kev txhaj tshuaj gentamicin. Tshuaj pleev, qhov muag tawm thiab aerosol tsis muab cov nyhuv zoo li. Cov tsos mob ntawm kev haus ib ce muaj xws li:

xeev siab thiab ntuav
tsaug zog thiab mob taub hau
tawv nqaij ua pob, khaus,
npaws
tsis paub kev lag ntseg
ua txhaum ntawm txoj haujlwm ntawm vestibular apparatus,
lub raum tsis ua hauj lwm
ua txhaum ntawm txoj kev tso zis,
Quincke's edema (tsis tshua muaj).

Cov kev kho mob cuam tshuam nrog kev tshem tawm tshuaj tam sim thiab ntxuav ntshav nrog hemodialysis lossis lim ntshav.

Kev cuam tshuam nrog lwm yam tshuaj

Ua tsis tiav nrog gentamicin yog:

Amphotericin
Heparin
Tshuaj tua kab mob beta-lactam.

Gentamicin txuam nrog ethacrylic acid thiab furosemide tuaj yeem txhim kho lub txiaj ntsig tsis zoo rau lub raum thiab pob ntseg tsis hnov lus.

Kev txhim kho ntawm kev ua pa ntawm kev ntes thiab ua rau cov leeg nqaij tuaj yeem ua rau tib lub sijhawm siv Gentamicin nrog cov tshuaj xws li:

Nws tsis pom zoo kom ua ke nrog Gentamicin nrog cov tshuaj hauv qab no:

Viomycin,
Vancomycin
Tobramycin,
Streptomycin,
Paromomycin,
Amikacin
Kanamycin,
Cephaloridin.

Nws tsis pom zoo kom ua ke nrog Gentamicin nrog Vancomycin.
Nws tsis pom zoo kom ua ke nrog Gentamicin nrog Amikacin.
Nws tsis pom zoo kom ua ke nrog Gentamicin nrog Streptomycin.
Nws tsis pom zoo kom ua ke nrog Gentamicin nrog Kanamycin.
Nws tsis pom zoo kom ua ke nrog Gentamicin nrog Tobramycin.

Cov qauv ntawm cov tshuaj txhaj yog:

Gentamicin Sandoz (Poland, Slovenia),
Gentamicin-K (Slovenia),
Gentamicin-Kev Noj Qab Haus Huv (Ukraine).

Cov tshuaj tiv thaiv qhov tshuaj nyob rau hauv daim ntawv ntawm lub qhov muag pom yog:

Lwm Haiv Neeg (Belarus),
Dexon (Is Nrias teb),
Dexamethasons (Russia, Slovenia, Finland, Romania, Ukraine).

Cov tshuaj pleev cov tshuaj pleev Gentamicin yog:

Candiderm (Is Nrias teb),
Garamycin (Belgium),
Celestroderm (Belgium, Russia).

Cov Lus Qhia Dex-Gentamicin Dexamethasone cov lus qhia Candiderm cov lus qhia Celestoderm-B cov lus qhia

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage daim ntawv ntawm Gentamicin sulfate - txhaj tshuaj: ntshiab, nrog me ntsis daj lossis zas xim hauv 2 ml iav ampoules, hauv lub thawv yas ntawm 5 lossis 10 ampoules lossis hauv cov thawv ntawv cardboard 1 pob ntawm 10 ampoules lossis 2 pob ntawm 5 ampoules (nyob ntawm los ntawm cov khw).

Cov lus sib xyaw ntawm 1 ml ntawm cov tshuaj:

cov tshuaj nquag: gentamicin (hauv daim ntawv ntawm gentamicin sulfate) - 40 mg,
kev tshem tawm (nyob ntawm tus tsim khoom): sodium metabisulfite, disodium ntsev ntawm ethylenediaminetetraacetic acid, dej rau txhaj, lossis anhydrous sodium sulfite thiab dej rau kev txhaj tshuaj.

Cia rau cov neeg mob rau cov tshuaj

Tshuaj yuav tsum muab khaws cia kom deb ntawm cov menyuam yaus. Cia qhov kub thiab txias rau kev txhaj tshuaj thiab qhov muag yuav tsum yog + 15 ... + 25 ° С, rau aerosol thiab tshuaj pleev - + 8 ... + 15 ° С.

Tshuaj yuav tsum muab khaws cia kom deb ntawm cov menyuam yaus.

Dosage daim ntawv

Kev daws rau kev txhaj 4%, 2 ml

2 ml ntawm kev daws

cov tshuaj nquag - gentamicin sulfate (hauv hais txog

gentamicin) - 80.0 mg,

tus zam: sodium metabisulfite, disodium edetate, dej rau kev txhaj tshuaj.

Pob tshab, tsis muaj kob los sis kua me ntsis

Kev tshuaj xyuas dua ntawm Gentamicin Sulfate

Maria, 25 xyoo, Voronezh: “Tau ob peb lub lis piam dhau los, muaj qee yam tau nkag mus rau hauv lub qhov muag. Qhov muag tau mob ib hnub, o (yuav luag kaw) thiab qhov mob uas tsis nco qab lawm tau tshwm sim. Tus kws kho mob qhia Gentamicin ua rau kuv tso. txhua txhua lwm hnub, thiab txog rau hnub thib 3 - cov tsos mob ntxiv dhau mus, tab sis kuv dripped tag nrho 7 hnub. "

Vladimir, hnub nyoog 40 xyoo, Kursk: “Kuv tau hlawv kuv txhais caj npab thaum ua haujlwm hnyav. Thaum yav tsaus ntuj pom lub ntsej muag tawm, ob peb hnub tom qab ntawd lub qhov txhab pib zoo thiab mob heev. qhov mob ntawd tsis tu lawm thiab pib zoo hlo. "

Andrei, 38 xyoo, Moscow: "Xyoo dhau los kuv tau mob ntsws. Kuv tsis tau pib kho mob tam sim ntawd, yog li thaum kuv mus rau hauv tsev kho mob tus kab mob tau mob los ntawm kev kub taub hau thiab hnoos heev.

Daim ntawv thiab cov qauv ntawm cov tshuaj

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm 4% daws rau kev txhaj tshuaj thiab qhov muag. Cov tshuaj tseem ceeb hauv cov tshuaj muaj pes tsawg leeg yog gentamicin sulfate ntawm ib koob ntawm 4 mg rau ib milliliter. Nws zwm rau cov pab pawg ntawm aminoglycosides thiab suav hais tias yog cov tshuaj tua kab mob ntau.

Cov tshuaj yog tawm rau kis thiab kis kev hauv lub cev uas tshwm sim los ntawm cov tshuaj tua kab mob-rhiab rau cov kab mob me me. Txog kev tswj hwm hauv niam txiv:

cystitis
mob hnoos qhuav
purulent txhab ntawm daim tawv nqaij,
hlawv ntawm ntau qib,
pyelonephritis,
cystitis
kab mob ntawm cov pob qij txha thiab pob txha ntawm ib qho kev sib kis,
sepsis
mob peritonitis
mob ntsws.

Thaum ua ntawv thov sab nrauv:

mob ntsws,
mob caj dab
seborrheic dermatitis,
mob kub tuag
mob qhov chaw ntawm ntau etiologies,
mob sycosis.

blepharitis
blepharoconjunctivitis,
dacryocystitis
pom mob pob txha
keratitis.

Nrog rau cov kev tawm tshiab, "Gentamicin sulfate" yog siv. Cov lus qhia rau kev siv yog nyob nruab nrab ntawm lub tsev muag tshuaj ntim nrog tshuaj.

muaj tshuaj tiv thaiv kom txo tau cov tshuaj tua kab mob,
mob nyhav ntawm lub raum thiab mob siab,
ua txhaum ntawm cov hlab auditory,
yoj tes
pub niam mis.

Tsis tas li, cov tshuaj tua kab mob Gentamicin Sulfate tsis tau raug sau tseg hauv ampoules rau uremia.

Cov tshuaj yog sau tseg ib tus zuj zus rau txhua tus neeg mob. Dosage nyob ntawm tus heev ntawm cov txheej txheem thiab hypersensitivity rau yeeb tshuaj. Txij li 1 txog 1.7 mg rau ib hlis twg ntawm lub cev hnyav yog muab rau ib zaug. Cov tshuaj yog txhaj rau hauv txoj hlab ntshav los yog intramuscularly. Cov tshuaj yog siv ob mus rau plaub zaug hauv ib hnub. Kev noj tshuaj ntau kawg hauv ib hnub yuav tsis ntau tshaj 5 mg. Lub chav kawm ntawm kev kho mob yog 1.5 lub lis piam.

Rau kev siv tshuaj pleev, qhov muag dauv nrog 1 poob txhua txhua ob teev. Rau kev siv sab nraud, cov tshuaj tau sau tseg txog peb zaug hauv ib hnub. Rau cov neeg muaj lub raum tsis zoo ua haujlwm, nyob ntawm seb lub chaw kuaj mob, kho cov tshuaj "Gentamicin Sulfate" tau ua. Cov tshuaj rau qhov muag tau tso ncaj qha rau lub hnab muag ntawm lub qhov muag mob.

Sib cuam tshuam nrog lwm txoj kev

Kev sib koom tes nrog cov tshuaj hauv qab no tsis pom zoo:

Vancomycin
Cephalosporin
"Ethacrylic acid",
Indomethacin
tshuaj loog,
analgesics
voj diuretics.

Ua ntej npaj kev kho mob, nws yog qhov yuav tsum tau ua tib zoo kawm txog kev cuam tshuam ntawm lwm cov tshuaj thiab cov tshuaj tua kab mob Gentamicin Sulfate.

xeev siab
ntuav
nce bilirubin nyob rau hauv cov ntshav,
anemia
thrombocytopenia
mob leukemia
mob taub hau
kiv taub hau
proteinuria
kev puas tsuaj ntawm cov khoom siv vestibular.

Nws kuj tseem tuaj yeem ua rau muaj kev tsis haum tshuaj "Gentamicin sulfate." Ncos thiab tshuaj hauv cov tsis tshua muaj tshwm sim tuaj yeem ua rau Quincke's edema lossis anaphylactic kev poob siab, uas yog fraught nrog cov kev mob hnyav. Thaum siv cov tshuaj tua kab mob, nws yog qhov tsim nyog los tswj lub luag haujlwm ntawm lub raum, pob ntseg thiab cov khoom siv vestibular.

"Gentamicin sulfate" - tshuaj tua kab mob rau tsiaj

Cov tsiaj kuj tseem tuaj yeem cuam tshuam los ntawm kev kis kab mob. Rau kev kho mob ntawm tus tsiaj muaj mob, tshwj xeeb pawg ntawm tshuaj tua kab mob yog siv. Cov tshuaj no suav nrog Gentamicin Sulfate. Nws yog rau pawg aminoglycosides thiab yog kev sib xyaw ntawm gentamicins C1, C2 thiab C1a. Cov tshuaj muaj pes tsawg leeg suav nrog gentamicin hauv ib koob 40 thiab 50 mg hauv ib milliliter ntawm kev daws. Cov khoom lag luam yog khaws cia hauv qhov kub tsis tshaj 25 degrees, nyob hauv qhov chaw qhuav tsis muaj menyuam yaus. Ob xyoos - lub txee lub neej ntawm cov tshuaj "Gentamicin sulfate." Cov lus qhia rau kev siv rau tsiaj yuav qhia koj hauv kev nthuav dav hais txog kev ntsuas thiab ntau npaum li cas ntawm cov tshuaj.

Cov tshuaj muaj qhov pom dav ntawm cov teebmeem thiab muaj kev ua haujlwm tiv thaiv cov kab mob gram-positive thiab gram-tsis zoo. Tom qab tswj hwm tshuaj, nws nkag mus rau tag nrho cov plab hnyuv siab raum thiab cov kab ke hauv lub sijhawm luv. Tom qab ib teev, nws qhov kev ua haujlwm siab tshaj plaws raug saib thiab kav rau 8 teev. Nws yog tawm hauv feem ntau hauv cov zis thiab hauv cov concentration me me nrog tsiaj quav.

Txog kev kho mob ntawm tus nees, ib qho tshuaj tua kab mob raug muab rau tshuaj intramuscularly ntawm ib koob ntawm 2.5 mg rau ib phaus ntawm qhov hnyav. Lub sijhawm kho yog los ntawm 3 txog 5 hnub. Rau cov nyuj, koob tshuaj yog muab rau ntawm tus nqi ntawm 3 mg rau ib phaus ntawm lub cev hnyav rau 5 hnub. Tsis tas li, cov tshuaj tuaj yeem siv rau qhov ncauj ntawm qhov ntau ntawm 8 mg rau ib phaus ntawm qhov hnyav.

Kev daws yog muab rau npua ua intramuscularly ntawm tus nqi ntawm 4 mg rau 1 kilogram ntawm qhov hnyav. Lub sijhawm kho mob yuav tsum tsis pub tshaj peb hnub. Cov tshuaj yog muab noj ntawm qhov ncauj ntawm ib koob ntawm 4 mg rau ib phaus ntawm lub cev hnyav rau 5 hnub. Cov dev thiab tus miv tau muab rau hauv intramuscularly 2.5 mg ntawm kev daws rau ib kilogram ntawm qhov hnyav. Txoj kev kho mob yuav siv sijhawm txog xya hnub.

Thaum siv sab hauv, cov tshuaj tsis nqus rau hauv plab, tab sis tsuas yog tom qab 12 teev hauv cov hnyuv. Tsuas yog tus kws kho tsiaj muaj peev xwm siv cov tshuaj tua kab mob Gentamicin Sulfate intramuscularly. Cov lus qhia rau cov tsiaj piav qhia txog yuav ua li cas tswj cov tshuaj.

Cov tshuaj "Gentamicin"

Cov tshuaj yog tshuaj tua kabmob los ntawm pawg aminoglycosides, uas tau siv dav los kho ntau yam kabmob. Cov cuab yeej muaj qhov tsis zoo hauv qab no ntawm lub cev:

tua kab mob
anti-inflammatory
muaj lub siab ua haujlwm tawm tsam cov kab mob gram-zoo thiab gram-tsis zoo.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm kev daws. Tom qab kev tswj hwm intramuscular, cov tshuaj tau sai sai rau hauv cov ntaub so ntswg ntawm tag nrho lub cev. Qhov siab tshaj plaws kev nyab xeeb yog pom tom qab ib nrab ib teev. Ib nrab ntawm cov tshuaj tom qab 3 teev yog tawm hauv cov zis. Ua kom dhau ntawm cov txiaj ntsig, yog li ntawd, nws tsis pom zoo kom sau cov tshuaj "Gentamicin" thiab nws cov tshuaj sib ntxiv "Gentamicin sulfate" thaum cev xeeb tub. Cov lus qhia rau kev siv cov nyiaj no muaj cov ntaub ntawv muaj txiaj ntsig zoo thiab cov lus piav qhia txog tshuaj tua kab mob.

Kev taw qhia thiab contraindications

Kev kho mob ntawm kev kis mob thiab kev mob uas tshwm sim los ntawm cov kab mob me me uas nkag mus rau cov khoom nquag tuaj yeem nqa tawm los ntawm tus neeg sawv cev ntawm Gentamicin. Cov tshuaj yog siv rau cov niam txiv, kev siv sab nraud thiab hauv nroog.

kev tiv thaiv kab mob rau pab pawg aminoglycoside,
yoj tes
kev pub mis
mob raum tsis ua haujlwm,

Ua ntej pib txoj kev kho mob, nws tsim nyog los ua tib zoo kawm tag nrho cov contraindications rau kev siv ntawm cov tshuaj tua kab mob Gentamicin thiab Gentamicin Sulfate.

Cov tshuaj yog raug sau tseg ntawm tus kheej, qhov koob tshuaj yog nyob ntawm qhov mob hnyav ntawm tus kab mob. Txog rau kev tswj hwm intramuscular thiab leeg, tshuaj tau raug suav ntawm ib koob tshuaj 1 txog 1.7 mg rau ib phaus ntawm lub cev hnyav ntawm ib zaug. Cov tshuaj raug tswj ob lossis peb zaug ib hnub. Kev tso cai ntau tshaj plaws rau ib tus neeg laus yuav tsum tsis pub tshaj 5 mg / kg, thiab rau cov menyuam yaus - 3 mg rau ib phaus ntawm qhov hnyav. Cov tshuaj raug muab tshuaj rau 7 hnub. Cov tee qhov muag tau siv peb zaug ib hnub thiab muaj kev tso ib qho ntsaws ncaj qha rau hauv lub qhov muag cuam tshuam. Cov tshuaj tua kab mob yog siv rau sab nraud plaub zaug hauv ib hnub. Hauv kev mob raum rov qab, cov tshuaj tau raug raws li cov duab hauv chaw kuaj mob, thiab cov koob tshuaj tuaj yeem hloov kho. Rau cov menyuam yaus, txoj cai niaj hnub nyob ntawm lub hnub nyoog thiab mob ntawm lub cev.

Yeeb tshuaj sib cuam tshuam

Gentamicin tsis pom zoo rau kev siv ua ke nrog cov tshuaj hauv qab no:

Vancomycin
Cephalosporin
"Ethacrylic acid",
Indomethacin
analgesics
tshuaj rau tshuaj loog,
tshuaj kho mob.

Cov tshuaj "Gentamicin" thiab cov tshuaj "Gentamicin sulfate 4%" muaj tib cov tshuaj sib tov thiab taw qhia rau kev siv. Ob qho tshuaj muaj tshuaj tiv thaiv kab mob ntau ntxiv thiab tiv thaiv.

Cov tshuaj "Gentamicin-Ferein"

Cov tshuaj yog rau cov pab pawg ntawm aminoglycosides thiab dav siv los kho ntau yam plab hnyuv siab raum thiab cov kab ke. Nws tau nce kev ua si rau cov kab mob gram-positive thiab gram-negative anaerobic. Nws muaj cov nyhuv bactericidal. Tom qab ua haujlwm, cov tshuaj tua kab mob yog nqus tau intramuscularly thiab mob siab rau txhua qhov plab hnyuv siab raum thiab cov ntaub so ntswg ntawm lub cev.

Dosage ntawm cov tshuaj "Gentamicin-Ferein"

Rau cov neeg laus, cov tshuaj raug muab rau hauv qhov ntau tsis ntau tshaj 5 mg rau ib kilogram ntawm lub cev qhov hnyav hauv ib hnub. Ntawm ib koob, koob tshuaj yog los ntawm 1 txog 1.7 mg rau 1 kilus ntawm tus neeg mob qhov hnyav. Lub chav kawm ntawm kev kho mob yog nyob ntawm qhov mob hnyav ntawm cov txheej txheem thiab thaj tsam li 7 txog 10 hnub. Cov tshuaj no tau pom ob lossis peb zaug hauv ib hnub

Rau cov menyuam yaus, qhov tshuaj yog 3 mg rau ib phaus ntawm lub cev hnyav hauv ib qhov kev saib xyuas. Cov tshuaj yog txhaj ob zaug ib hnub. Rau cov neeg mob raum tsis ua haujlwm, qhov ntau npaum li cas ntawm cov tshuaj tua kab mob tau hloov kho tas li thiab nyob ntawm qhov ntsuas kev kuaj mob.

Cov tee qhov muag tau siv txhua 4 teev thiab muaj qhov ntsaws qhov muag rau ib qho zuj zus. Outwardly, cov tshuaj yog kws kho peb lossis plaub zaug ib hnub.

Cov tshuaj phiv:

xeev siab
ntuav
nce bilirubin,
anemia
leukopenia
tsaug zog
mob taub hau
kev puas tsuaj ntawm cov khoom siv vestibular,
lag ntseg
kev tsis haum tshuaj, mus txog Quincke's edema.

Cov kev mob tshwm sim zoo ib yam yuav muaj kev daws teeb meem ntawm "Gentamicin Sulfate 4%" thaum kho cov mob sib kis thiab mob hauv lub cev.

Kev tshuaj xyuas khoom raws li gentamicin sulfate

Cov tshuaj tsis yog nyob rau tiam tshiab ntawm cov tshuaj tua kab mob, tab sis lawv siv tau zoo heev hauv peb lub sijhawm los kho cov kab mob microbial. Yog li, lub khw muag tshuaj muaj ntau cov khoom uas suav nrog gentamicin. Qhov no tsis yog tsuas yog tov rau kev txhaj tshuaj xwb, tab sis kuj tseem pleev, tshuaj pleev, pleev qhov muag. Cov tshuaj cuam tshuam rau cov ntaub ntawv caj ces uas nyob hauv cov hlwb ntawm lub cev. Cov nquag ua haujlwm yog nqus tau mus rau hauv lub cev cov ntaub so ntswg hauv lub sijhawm luv luv thiab pib nws cov nyhuv antibacterial.

Feem ntau, cov tshuaj tau pom zoo zoo, tab sis tuaj yeem ua rau muaj kev tsis haum. Tsis tas li, ib qho tshuaj tua kab mob tuaj yeem nqa los ntawm hnub yug. Muaj ib lub tswv yim tshwj xeeb muab xam rau qhov no. Cov tshuaj tua kab mob no yog siv dav hauv cov tsiaj kho tsiaj. Nws pab cov tsiaj tua kab mob thiab ua haujlwm zoo rau lub plab thiab txoj hnyuv.

Qee zaum cov tshuaj "Gentamicin" tuaj yeem ua rau tsis hnov lus, thiab qhov no yog nws qhov ua tsis tau zoo. Txheeb xyuas txhua qhov kev tshuaj xyuas, tshwj xeeb yog cov kws kho mob, koj tuaj yeem nkag siab tias hom tshuaj tua kab mob no muaj zog npaum li cas. Nws muaj lub siab ua haujlwm tiv thaiv gram-zoo thiab gram-negative anaerobic yam muaj sia. Tsis tas li ntawd nyob rau hauv cov nyuaj tau sau tseg rau kev kho mob mob ntsws thiab mob daim npluag paj hlwb. Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam nruj ntawm cov tshuaj ntawm kom tsis txhob phiv. Raws li cov kws tshaj lij txoj cai, cov tshuaj "Gentamicin sulfate" yog lom. Nws siv tas li tuaj yeem cuam tshuam kev ua haujlwm ntawm txhua lub cev. Cov tshuaj tua kab mob yuav tsum tsis txhob siv yam tsis tau sab laj nrog tus kws tshaj lij.

Pharmacological thaj chaw ntawm cov tshuaj Gentamicin sulfate

Cov Tshuaj Hauv Tshuaj Gentamicin yog ib qhov tshuaj tua kab mob ntau yam ntawm aminoglycoside pawg. Lub tshuab kev ua haujlwm tau txuam nrog kev txwv tsis pub ntawm 30S ribosomal subunits. Kev Xeem n vitro paub meej tias nws cov haujlwm nrog kev sib txawv ntawm cov kab mob gram-zoo thiab gram-tsis zoo: Escherichia coli, Proteus spp. (indole zoo thiab indole tsis zoo), Pseudomonas aeruginosa, Klebsiella spp., Enterobacter spp., Citrobacter spp., Salmonella spp., Shigella spp. thiab Dab Tsi Staphylococcus sppCov. (suav nrog rau cov leeg penicillin thiab methicillin tiv thaiv lim).
Cov kab mob me hauv qab no feem ntau tiv taus gentamicin: Kab mob ntsws dej liab, feem ntau lwm hom streptococci, enterococci, Neisseria meningitides, Treponema pallidum thiab anaerobic cov kab mob me me xws li Bacteroides sppCov. lossis Clostridium spp.
Cov Tshuaj PharmacokineticsCov. Gentamicin nkag tau yooj yim, nce mus txog qhov ntshav siab tshaj plaws 30-60 feeb tom qab i / m tswj hwm.
Kev kho ntshav cov ntshav muaj ntau nyob rau 6-8 teev.
Nrog iv nrog kua, qhov kev xav ntawm cov tshuaj tua kab mob hauv cov ntshav ntshav thaum thawj teev dhau ntawm kev saib xyuas uas tau ua tiav tom qab IM tswj hwm ntawm cov tshuaj. Kev khi rau cov ntshav plasma protein yog 0-10%.
Hauv kev kho ntau, nws yog txiav txim siab hauv cov nqaij ntawm ob lub raum, mob ntsws, hauv pleural thiab peritoneal exudates. Nquag, nrog rau kev tswj hwm hauv tsoomfwv, gentamicin nkag mus rau qhov tsis zoo los ntawm BBB, tab sis nrog kev mob rau daim npluag paj hlwb, qhov siab nyob hauv CSF nce siab. Cov tshuaj kis tau rau niam mis.
Kwv yees li 70% ntawm gentamicin yog cov tsis hloov pauv hauv cov zis thaum nruab hnub los ntawm kev lim dej ntawm glomerular. Ib nrab-lub neej los ntawm cov ntshav ntshav yog kwv yees li 2 teev.

Kev taw qhia rau kev siv cov tshuaj Gentamicin sulfate

Muab thaj tsam ntawm thaj tsam ntawm kev kho kab mob gentamicin, nws yuav tsum siv rau hauv cov kis mob uas muaj kab mob me tiv taus lwm cov tshuaj tua kab mob. Gentamicin sulfate raug kho rau kev kho mob los ntawm kev kis los ntawm cov kab mob nkag rau nws, suav nrog:

sepsis
mob txeeb zig
cov kab mob ntawm cov pa hauv theem qis,
kis kab mob ntawm daim tawv nqaij, pob txha, cov nqaij mos,
mob kub hnyiab txhab,
CNS kis mob (mob hlwb) ua ke nrog cov tshuaj tua kab mob beta-lactam,
mob plab (peritonitis).

Kev siv cov tshuaj Gentamicin sulfate

Gentamicin sulfate tuaj yeem siv IM lossis IV.
Qhov koob tshuaj, txoj kev ntawm kev tswj hwm thiab ncua sij hawm ntawm koob tshuaj yog nyob ntawm qhov mob hnyav ntawm tus kab mob thiab tus mob ntawm tus neeg mob.
Kev noj tshuaj ntxiv
Cov neeg lausCov. Kev noj tshuaj ib txwm niaj hnub rau cov neeg mob uas muaj kev mob nyhav thiab hnyav ntawm kev kis tus kab mob yog 3 mg / kg lub cev hnyav IM lossis IV hauv 2-3 qhov kev qhia.Qhov koob tshuaj txhua hnub rau cov neeg laus yog 5 mg / kg lub cev qhov hnyav hauv 3-4 hno.
Lub sijhawm ib txwm siv ntawm cov tshuaj rau txhua tus neeg mob yog 7-10 hnub.
Yog tias tsim nyog, thaum muaj mob hnyav thiab mob hnyav, lub chav kawm kev kho mob tuaj yeem txuas ntxiv. Hauv cov xwm txheej zoo li no, nws raug nquahu kom saib xyuas txoj haujlwm ntawm lub raum, kev tshuaj xyuas thiab lub tshuab ua pa, txij li qhov ua kom tsis zoo ntawm cov tshuaj tshwm sim tom qab nws siv tom qab ntau tshaj 10 hnub.
Muab xam los ntawm lub cev nyhav uas gentamicin yuav tsum yog kws kho.
Qhov muab tshuaj yog xam raws qhov tseeb ntawm lub cev qhov hnyav (BMI) yog tias tus neeg mob tsis muaj qhov hnyav tshaj (uas yog, ib qho ntxiv tsis ntau tshaj 20% ntawm qhov zoo tshaj lub cev qhov hnyav (BMI)). Yog tias tus neeg mob hnyav tshaj lub cev qhov hnyav, qhov koob tshuaj yog txiav txim siab los ntawm qhov hnyav ntawm lub cev (DMT) raws li cov mis:
DMT = BMI + 0.4 (FMT - BMI).
Cov menyuamCov. Rau cov menyuam yaus hnub nyoog qis dua 3 xyoos, gentamicin sulfate raug kho tsuas yog rau kev mob nkeeg. Qhov koob tshuaj txhua hnub yog: hauv cov menyuam mos yug tshiab thiab cov menyuam mos - 2-5 mg / kg, hauv cov menyuam hnub nyoog 1-5 xyoos - 1.5–3 mg / kg, 6–14 xyoo - 3 mg / kg. Qhov tshuaj ntau tshaj rau cov me nyuam txhua hnub yog 5 mg / kg. Cov tshuaj raug muab tshuaj 2-3 zaug nyob rau ib hnub.
Thaum lub cev tsis ua haujlwm ntawm lub raum, nws yog qhov yuav tsum hloov cov kev noj tshuaj ntau npaum li cas kom nws tuaj yeem lav tau ntawm qhov ua kom zoo ntawm kev kho mob. Nws yog ib qho tsim nyog los tswj kev xav ntawm gentamicin hauv cov ntshav cov ntshav. 30-60 feeb tom qab iv lossis kev tswj hwm intramuscular, qhov kev nqus ntawm cov tshuaj hauv cov ntshav cov ntshav yuav tsum yog 5-10 μg / ml. Thawj koob tshuaj gentamicin rau cov neeg mob uas muaj kev ruaj khov ntawm kev mob raum ua kom tsis zoo yog 1-1.5 mg / kg lub cev hnyav, ntxiv cov koob tshuaj thiab lub sij hawm nruab nrab ntawm kev tswj hwm yog txiav txim siab nyob ntawm creatinine tshem tawm.

Qev ntawm kev tswj hwm (h)

Cov neeg mob loj uas muaj cov kab mob uas yuav tsum tau lim ntshav yog tso 1-1.5 mg ntawm gentamicin rau 1 kg ntawm lub cev qhov hnyav ntawm qhov kawg ntawm txhua lub lim ntshav.
Nrog peritoneal lim ntshav hauv cov neeg laus, 1 mg ntawm gentamicin ntxiv rau 2 l ntawm kev lim ntshav.
Nrog rau / hauv cov lus qhia ntawm cov ntim ntawm ib txwm muaj kuab tshuaj (0.9% ntawm cov tshuaj sodium chloride lossis 5% ntawm cov dej qabzib) yog 50-300 ml rau cov neeg laus, rau cov menyuam yaus, qhov ntim ntawm cov kuab tshuaj yuav tsum txo kom tsawg. Lub sijhawm ntawm on / nyob rau hauv Txoj kev lis ntshav yog 1-2 teev, yeeb tshuaj yog muab nyob rau ntawm tus nqi ntawm 60-80 tee nyob rau hauv 1 min.
Qhov kub siab ntawm gentamicin hauv kev daws yuav tsum tsis txhob ntau dua 1 mg / ml - 0.1%.
Hauv / hauv kev qhia ntawm cov tshuaj yog nqa tawm rau 2-3 hnub, tom qab ntawd lawv hloov mus rau a / m txhaj tshuaj.

Cov Tshuaj Hauv Tshuaj

Gentamicin sulfate yog cov tshuaj tua kab mob aminoglycoside nrog rau kev ua kom dav. Los ntawm kev nkag mus rau cov kab mob hauv cov cell membrane thiab rov qab tsis tau los ua kom cov kab mob sib kis mus rau 30S subunits, nws cuam tshuam cov synthesis ntawm cov protein pathogen. Gentamicin tiv thaiv kev tsim cov txheej txheem ntawm tRNA (thauj ribonucleic acid) thiab mRNA (matrix ribonucleic acid), yog li ntawd, nyeem tsis raug ntawm cov caj ces ntawm mRNA thiab kev tsim cov protein tsis ua haujlwm tshwm sim.

Tshuaj tua kab mob hauv cov siab zoo yuav pab txo cov teeb meem thaiv kab mob ntawm cov ntshav ua pa nyob rau hauv cov kab mob ntawm cov kab mob me, ua rau lawv tuag. Qhov no ua rau cov nyhuv bactericidal ntawm gentamicin.

Hauv kev tshuaj ntsuam hauv vitro paub meej tias kev ua haujlwm ntawm gentamicin sulfate tawm tsam cov kab mob gram-negative thiab cov kab mob gram-zoo: Proteus spp. (indolegative thiab indolpositive), Escherichia coli, Salmonella spp., Klebsiella spp., Campylobacter spp., Shigella spp., Staphylococcus spp. (suav nrog rau penicillin- thiab kab mob methicillin-tiv taus kab mob), Pseudomonas spp. (suav nrog Pseudomonas aeruginosa), Serratia spp., Providencia spp., Citrobacter spp., Acinetobacter spp.

Cov kab mob me me hauv qab no feem ntau tiv taus gentamicin: Streptococcus pneumoniae, feem ntau lwm yam kabmob streptococci, enterococci, Neisseria meningitides, Treponema pallidum thiab anaerobic microorganisms xws li Clostridium spp., Bacteroides spp., Providencia rettgeri.

Gentamicin txuam nrog penicillins (suav nrog benzylpenicillin, ampicillin, oxacillin, carbenicillin), uas cuam tshuam rau lub cell phab ntsa ntawm microorganisms, yog nquag tiv thaiv Enterococcus faecium, Enterococcus faecalis, Enterococcus avium, Enterococcus durans, yuav luag txhua yam Streptococcus dawm, thiab txhua yam ntawm Streptococcus straptococcus faecalis zymogenes, Streptococcus faecalis liquefaciens), Streptococcus durans, Streptococcus faecium.

Kev loj hlob ntawm cov microorganism tsis kam rau gentamicin yog qeeb. Vim tsis tiav qhov ua tsis taus tus ntoo khaub lig-tiv thaiv, kev tawm tsam pom tias qhov ua rau kanamycin thiab neomycin yuav tiv thaiv gentamicin. Cov tshuaj tua kab mob kuj tseem tsis ua rau cov kab mob hu ua fungi, fungi, protozoa.

Tom qab tso tshuaj (i / v) lossis tshuaj intramuscular (i / m), kev kho tshuaj ntau ntawm gentamicin hauv cov ntshav tau mus txog kwv yees li 0.5-1.5 teev thiab kav ntev txog 8 txog 12 teev.

Kev phiv los ntawm cov tshuaj Gentamicin sulfate

Totoxicity (kev puas tsuaj rau VIII khub ntawm cranial qab haus huv): kev hnov lus tsis zoo thiab kev puas tsuaj rau lub tsho khuam ntawm lub cev yuav tsim muaj (nrog rau kev puas tsuaj rau lub vestibular lub tshuab, cov teeb meem no hauv qee kis yuav txawm tsis paub txog hauv thawj qib). Ntawm kev pheej hmoo tshwj xeeb tuaj yeem ua rau ncua ntev kev kho mob nrog gentamicin - 2-3 lub lis piam.
Nephrotoxicity: qhov ntau zaus thiab mob hnyav ntawm lub raum puas yog nyob ntawm qhov loj ntawm koob tshuaj ib zaug, lub sijhawm kho mob thiab tus yam ntxwv ntawm tus neeg mob, qhov zoo ntawm kev tswj kev kho thiab kev siv tib lub sijhawm tshuaj nephrotoxic.
Lub raum puas tsuaj yog tshwm sim los ntawm proteinuria, azotemia, tsawg zaus - oliguria, thiab, raws li txoj cai, yog qhov thim rov qab.
Lwm cov kev mob tshwm sim uas tsis tshua muaj yog: txhawb siab cov ntshav hloov pauv (ALAT, ASAT), bilirubin, reticulocytes, nrog rau thrombocytopenia, granulocytopenia, ua rau lub cev tsis muaj ntshav ntau, txo cov ntshav calcium, cov tawv nqaij ua pob, urticaria, mob pruritus, kub taub hau, mob taub hau, ntuav mob leeg.
Tsis tshua muaj, kev mob tshwm sim tshwm sim: xeev siab, nce ntxiv salivation, tsis qab los, poob ceeb thawj, purpura, laryngeal edema, mob pob qij txha, mob ntshav khov thiab tsaug zog, txhaws ntawm neuromuscular conduction thiab ua pa nyuaj siab tau.
Ntawm thaj chaw ntawm i / m tswj hwm ntawm gentamicin, mob hnyav yog ua tau, nrog / / hauv cov lus qhia - kev txhim kho phlebitis thiab periphlebitis.

Kev sib cuam tshuam yeeb tshuaj Gentamicin sulfate

Kev sib txig nrog kev tswj hwm nrog lub zog tshuaj loog (furosemide, ethacrylic acid) yuav tsum zam, vim tias tom kawg tuaj yeem txhim kho cov nyhuv ototoxic thiab nephrotoxic. Muaj peev xwm ua tsis taus pa ntawm lub cev vim tias cov hlab hlwb ua rau cov neeg mob uas ib txhij kho cov leeg ua si (succinylcholine, tubocurarine, decamethonium), ua kom loog, lossis yav dhau los cov ntshav sib ntxiv uas yog siv cov citrate anticoagulant tau sau tseg hauv keeb kwm. Kev siv cov ntsev calcium thiab cov tshuaj tiv thaiv anticholinesterase tuaj yeem tshem tawm cov kev cuam tshuam ntawm kev thaiv neuromuscular.
Kev sib txig sib law liag thiab / los sis siv cov kev ua tau zoo los yog siv cov tshuaj lwm yam neuro- thiab / los yog nephrotoxic cov neeg sawv cev xws li cisplatin, cephaloridin, tshuaj tua kab mob aminoglycoside, polymyxin B, colistin, vancomycin yuav tsum zam.
Txoj kev pheej hmoo ntawm lub cev tsis zoo ua kom nce ntxiv nrog kev siv tib lub sijhawm ua ke nrog gentamicin, indomethacin thiab lwm yam NSAIDs, zoo li quinidine, cyclophosphamide, ganglion blockers, verapamil, polyglucin. Gentamicin tsub kom lom ntau dua ntawm digoxin.
Nrog rau kev tswj hwm tib lub sijhawm ntawm aminoglycosides thiab penicillins, kev tshem tawm ib nrab ntawm lub neej txo qis thiab lawv cov ntsiab lus hauv cov ntshav cov ntshav tsawg zuj zus.
Ib nrab-lub neej txo qis hauv cov neeg mob uas lub raum tsis zoo nrog kev siv cov carbenicillin nrog gentamicin.
Thaum muab sib xyaw hauv ib qho ntim ntawm cov tshuaj tua kab mob ntawm aminoglycoside pawg nrog cov tshuaj tua kab mob ntawm pawg beta-lactam (penicillins, cephalosporins), kev sib nrig sib ua tsis tau. Gentamicin tseem yog cov tshuaj pharmacologically tsis haum nrog amphotericin, heparin.

Gentamicin sulfate noj ntau tshaj, cov tsos mob thiab kev kho mob

Yog hais tias haus dej ntau dhau los yog thaum muaj tshuaj lom cov tshuaj lom nrog cov cim lossis cov tsos mob ntawm tus mob nephrotoxicity lossis ototoxicity thiab neuromuscular thaiv nrog kev ua pa tsis ua haujlwm, hemodialysis tuaj yeem pab txhawb kev tshem tawm gentamicin los ntawm ntshav ntshav, nrog peritoneal dialysis, tus nqi ntawm kev tshem tawm cov tshuaj muaj qis dua. Menyuam mos yug tshiab, hloov pauv ntshav yuav ua tau.
Txoj kev kho yog mob.

Tsuas tshuaj thiab tswj hwm

Hauv / m, hauv / nrog dej 2-3 zaug hauv ib hnub.

Thaum muaj mob txeeb zig, tso ib zaug tshuaj yog 0.4 mg / kg, ib hnub - txog 1.2 mg / kg.

Nrog rau sepsis thiab lwm yam kev kis mob hnyav, ib koob tshuaj yog 0.8-1 mg / kg. Qhov pom zoo txhua hnub yog 2.4-3.2 mg / kg, thiab qhov nyiaj pab ntau tshaj plaws yog 5 mg / kg. Qhov kev kawm yog 7-8 hnub.

Cov koob tshuaj txhua hnub rau cov menyuam mos thiab menyuam mos yog 2-5 mg / kg, 1–5 xyoos –– 1.5–3 mg / kg, 6–14 xyoo –– 3 mg / kg.

Cov lus qhia rau kev siv Gentamicin sulfate: txoj kev thiab ntau npaum li cas

Gentamicin sulfate tau qhia rau hauv / m lossis / hauv.

Rau iv kev lis ntshav, koob tshuaj ntawm cov tshuaj yog diluted nrog cov kuab tshuaj (cov tshuaj tsw qab los yog 5% piam thaj tov). Rau cov neeg laus, cov niaj zaus ntim hnyav yog 50-300 ml, rau cov menyuam nws yuav tsum raug txo kom tsawg. Hauv kev daws, qhov tseem ceeb ntawm gentamicin yuav tsum tsis pub ntau tshaj 0.1% (1 mg / ml). Lub sijhawm ntawm iv Txoj kev lis ntshav ntawm Gentamicin sulfate yog 1-2 teev.

Txoj kev ntawm cov thawj coj thiab kev noj ntau npaum li cas ntawm gentamicin sulfate nyob ntawm seb tus mob ntawm tus neeg mob thiab qhov mob hnyav npaum li cas. Cov koob tshuaj yog suav raws li qhov hnyav ntawm tus neeg mob.

Vim tias qhov tseeb tias gentamicin tau faib rau hauv cov kua dej ntxiv thiab tsis tuaj yeem nkag rau hauv cov ntaub so ntswg adipose, nws cov koob tshuaj yuav tsum raug txo qis thaum rog dhau los. Qhov tshuaj yuav tsum tau muab xam rau ntawm FMT (qhov hnyav ntawm lub cev), yog tias tus neeg mob tsis rog dhau, uas yog, tsis tshaj 20% ntawm BMI (zoo tshaj lub cev qhov hnyav). Yog tias nyhav dhau ntawm 20% lossis ntau dua rau BMI, qhov koob tshuaj rau lub cev qhov hnyav (DMT) yog xam los ntawm cov mis: DMT = BMI + 0.4 (FMT - BMI).

Cov tshuaj pom zoo:

rau cov laus thiab menyuam yaus hnub nyoog dhau 14 xyoos: rau kev sib kis mob hnyav thiab mob hnyav, kev noj tshuaj ib txwm ib hnub ntawm gentamicin yog 3 mg / kg hnyav, muab faib ua 2-3 koob. Qhov koob tshuaj txhua hnub yog 5 mg / kg, muab faib ua 3-4 hno,
rau cov menyuam yaus: txog li 3 xyoo muaj hnub nyoog Gentamicin sulfate raug kho tsuas yog rau kev mob nkeeg. Qhov koob tshuaj txhua hnub rau cov menyuam mos thiab menyuam mos yog 2-5 mg / kg, rau cov menyuam yaus txij 1 txog 5 xyoos - 1.5-3 mg / kg, rau cov menyuam muaj hnub nyoog 6 txog 14 xyoo - 3 mg / kg. Qhov koob tshuaj txhua hnub rau cov menyuam yaus ntawm txhua pawg hnub nyoog yog 5 mg / kg. Cov tshuaj raug muab tshuaj 2-3 zaug nyob rau ib hnub. Hauv txhua tus menyuam yaus, tsis hais hnub nyoog li cas, nws raug nquahu kom kuaj xyuas qhov gentamicin hauv cov ntshav ntshav txhua hnub (1 teev tom qab txhaj, nws yuav tsum kwv yees li 4 μg / ml),
rau cov neeg mob uas lub raum tsis ua hauj lwm: qhov ntau dua kev noj tshuaj yuav tsum tau xaiv kom nws thiaj li paub meej tias qhov ua kom zoo ntawm kev siv tshuaj tua kab mob. Ua ntej thiab thaum lub sijhawm kho tag nrho, nws yog ib qho tsim nyog yuav tsum tswj hwm qhov ntsuas ntawm gentamicin. Thawj koob tshuaj rau cov neeg mob uas lub raum tsis ua haujlwm ntev yog 1-1.5 mg / kg. 30-60 feeb tom qab i / m tswj hwm, kev saib xyuas ntawm cov tshuaj hauv cov ntshav cov ntshav yuav tsum yog 5-10 μg / ml. Yav tom ntej, cov koob tshuaj thiab lub sijhawm nruab nrab ntawm kev txhaj tshuaj yog txiav txim siab nyob ntawm QC (creatinine tshem tawm).

Lub sijhawm ib txwm muaj los ntawm kev kho nrog Gentamicin sulfate rau txhua tus neeg mob yog li ntawm 7 txog 10 hnub. Yog tias tsim nyog, thaum muaj mob hnyav thiab ua rau kis sib kis, txoj kev kho tuaj yeem txuas ntxiv. Txij li thaum lub cev muaj tshuaj lom ntawm cov tshuaj tua kab mob tshwm sim tom qab 10 hnub ntawm kev siv, nws raug nquahu kom soj ntsuam kev ua haujlwm ntawm lub raum, vestibular apparatus thiab lub rooj sib hais nrog kev kawm ntev dua.

Yog tias nws yuav tsum tau ua tus txheej txheem lim ntshav, cov neeg laus cov neeg mob uas tau kis tus kab mob tau sau tseg 1-1.5 mg / kg gentamicin tom kawg ntawm txhua tus txheej txheem.

Cev xeeb tub thiab lactation

Cov tshuaj yog contraindicated rau kev siv thaum cev xeeb tub, txij li gentamicin hla lub plab placental thiab tej zaum yuav muaj cov nyhuv nephrotoxic rau tus me nyuam hauv plab.

Gentamicin sulfate muaj cov khoom ntiag tug ntawm kev nkag mus rau niam mis, yog li yog tias yuav tsum tau siv nws nyob rau hauv tus poj niam thaum lactation, kev pub mis niam yuav tsum tsis ua haujlwm.

Thaum tsis ua haujlwm lub raum

Hauv cov neeg mob uas muaj mob tsis haum lub raum ua haujlwm nrog uremia thiab azotemia, zoo li hauv cov neeg mob uas mob raum tsis zoo, kev siv cov tshuaj yog contraindicated.

Txoj kev pheej hmoo ntawm kev tsim cov kev mob tshwm sim nephrotoxic thaum kho nrog gentamicin nce nrog kev ua haujlwm tsis zoo hauv lub raum. Yog li, ua ntej thiab nyob rau thaum tag nrho cov kev kho mob, nws yog ib qho tsim nyog los saib xyuas cov concentration ntawm gentamicin hauv cov ntshav, ntxiv rau tshuaj xyuas cov haujlwm ntawm lub raum.

Gentamicin sulfate yuav tsum tau siv rau kev mob raum tsis ua haujlwm raws li kev muab tshuaj.

Gentamicin sulfate tus nqi hauv cov chaw muag tshuaj

Tus nqi nruab nrab ntawm Gentamicin sulfate yog kwv yees li 33 rubles rau ib pob ntawm 10 ampoules.

Kev Kawm: Rostov State Medical University, tshwj xeeb "General Tshuaj".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Raws li kev tshawb fawb los ntawm WHO, kev sib tham ib nrab hnub nyob rau ntawm lub xov tooj ntawm tes tau qhov feem ntau ntawm kev txhim kho lub hlwb lub hlwb los ntawm 40%.

Hauv kev mob siab kom tau tus neeg mob tawm, cov kws kho mob feem ntau mus deb dhau. Yog li, piv txwv li, qee yam Charles Jensen nyob rau lub sijhawm txij xyoo 1954 txog 1994. muaj sia nyob ntau dua 900 lub neoplasm tshem tawm txoj haujlwm.

Thaum lub sijhawm ua haujlwm, peb lub hlwb siv ntau npaum li cas ntawm lub zog sib npaug rau 10-watt lub teeb lub teeb. Yog li cov duab ntawm lub teeb txawb saum koj lub taub hau thaum lub sijhawm pom ntawm qhov kev xav zoo nkauj tsis yog deb ntawm qhov tseeb.

Raws li kev txheeb cais, nyob rau hnub Monday, kev pheej hmoo ntawm nraub qaum nce ntxiv li 25%, thiab kev pheej hmoo ntawm mob plawv - los ntawm 33%. Kom ceev faj.

Txawm hais tias ib tug neeg lub siab tsis yeej, tam sim no nws tseem tuaj yeem nyob rau lub sijhawm ntev, zoo li tus neeg nuv ntses neeg Norwegian Jan Revsdal tau ua rau peb pom. Nws "lub cev muaj zog" nres rau 4 xuab moos tom qab tus neeg nuv ntses tau ploj thiab tsaug zog hauv cov daus.

Ntxiv rau tib neeg, tsuas yog ib tus tsiaj muaj sia nyob ntawm ntiaj chaw ntiaj teb - dev, raug kev txom nyem los ntawm prostatitis. Cov no yog peb cov phooj ywg ncaj ncees tshaj plaws.

Hauv 5% ntawm cov neeg mob, antidepressant clomipramine ua rau lub orgasm.

Nws tau siv los ua yawning enriches lub cev nrog oxygen. Txawm li cas los xij, lub tswv yim no tau sib kis. Cov kws tshawb fawb tau ua pov thawj tias yawning, ib tus neeg ua kom lub hlwb txias thiab txhim kho kev ua haujlwm.

Muaj 74 xyoo nyob hauv tebchaws Australian yawg James Harrison tau los ua neeg muab ntshav li 1,000 zaus. Nws muaj ib hom ntshav uas tsis tshua muaj, cov tshuaj tiv thaiv uas pab cov menyuam mos liab uas muaj ntshav tsawg txaus kom ciaj sia taus. Yog li, Australian thiaj cawm tau ntau txog ob lab tus menyuam.

Tib neeg cov ntshav "khiav" los ntawm cov hlab ntsha hauv qab qhov siab thiab, yog tias nws txoj kev ncaj ncees tau ua txhaum, tuaj yeem tua mus txog 10 meters.

Caries yog hom kis tau yooj yim tshaj plaws hauv ntiaj teb uas txawm tias tus mob npaws tsis tuaj yeem sib tw nrog.

Muaj ntau cov kev kho mob nthuav tawm heev, xws li kev siv khoom tsis nco qab ntawm cov khoom. Hauv plab ntawm ib tus neeg mob uas tau mob los ntawm tus txiv neej no, 2500 cov khoom txawv teb chaws tau pom.

Cov kws tshawb fawb los ntawm Oxford University tau ua cov kev tshawb fawb, thaum lub sijhawm lawv tau los txiav txim siab tias kev tsis noj zaub ua rau muaj kev puas tsuaj rau tib neeg lub hlwb, vim tias nws ua rau nws txo qis hauv nws qhov loj. Yog li cov kws tshawb fawb pom zoo kom tsis txhob cais cov ntses thiab nqaij los ntawm lawv cov kev noj haus.

Cov tshuaj hnoos "Terpincode" yog ib tus thawj coj hauv kev muag, tsis muaj vim tias nws muaj tshuaj.

Cov tshuaj muaj npe zoo "Viagra" tau tsim thaum chiv thawj los kho kev mob ntshav siab los ntawm arterial tawg.

Ib nrab ntawm cov hniav tsis txaus los yog ua tiav adentia tuaj yeem yog qhov tshwm sim ntawm kev raug mob, caries lossis kab mob pos hniav. Txawm li cas los xij, hniav ploj tuaj yeem hloov nrog cov hniav cuav.

Cov tshuaj sib cuam tshuam

Lub caij nyoog ntawm kev tsim neuromuscular blockade thiab ua pa tuag tes tuag taw yuav tsum tau coj mus rau hauv txhua txoj kev tswj hwm ntawm aminoglycosides hauv cov neeg mob tau txais cov tshuaj loog lossis tshuaj uas ua rau neuromuscular blockade, xws li succinylcholine, tubocurarine, decametonium, zoo li hauv cov neeg mob ua rau muaj kev cuam tshuam loj heev rau kev hloov ntshav. ntshav. Thaum neuromuscular blockade tshwm sim, muaj ntsev ntsev muab tshuaj.

Kev siv ib txhij los yog txuas rau cov kab ke lossis cov tshuaj siv lwm cov tshuaj neurotoxic lossis tshuaj nephrotoxic, xws li cisplatin, cephaloridin, kanamycin, amikacin, neomycin, polymyxin-B, colistin, paromyomycin, streptomycin, tobramycin, vancomycin thiab viomycin.

Nrog rau kev siv hydrocortisone thiab indomethacin ib txhij, cov nyhuv nephrotoxic ntawm gentamicin yuav kho kom zoo dua.

Nws yuav tsum tsis txhob siv ib txhij nrog furosemide thiab ethacrylic acid vim qhov tseeb tias muaj qhov nce ntawm ototoxic thiab nephrotoxic teebmeem yog tau. Tsis tas li ntawd, nrog kev siv tshuaj tso ntshav ntau, kev hloov pauv ntawm cov tshuaj tua kab mob hauv cov ntshav thiab cov nqaij mos yog qhov ua tau, uas ua rau muaj kev nce ntxiv hauv tshuaj lom tshwm sim los ntawm aminoglycosides.

Hauv cov neeg mob uas mob raum tsis zoo uas tau txais ob qho carbenicillin thiab gentamicin, qhov kev txo qis ntawm ib nrab ntawm lub neej gentamicin los ntawm ntshav tau pom.

Cov tshuaj tsis sib haum nrog tshuaj tua kab mob beta-lactam, heparins, amphotericin.

Daim ntawv tso tawm thiab ntim khoom

2 ml yog nchuav rau hauv ampoules ntawm koob txhaj tshuaj ntawm nruab nrab iav nrog lub taw tes lossis ntiv nplhaib ntawm qhov tsis to.

Daim ntawv lo los ntawm daim ntawv lo lossis daim ntawv sau sau yog lo rau txhua lub ampoule.

5 lossis 10 ampoules tau ntim rau hauv blister sawb ntim ua los ntawm cov yeeb yaj kiab ntawm polyvinyl chloride thiab aluminium ntawv ci.

Contour cov xov tooj ntawm tes ua ke nrog cov lus qhia pom zoo rau kev siv kho mob hauv lub xeev thiab Lavxias lus yog muab tso rau hauv cov thawv ntawv thawv rau cov neeg siv khoom ntim lossis corrugated.