Lantus - cov lus qhia rau kev siv, tshuaj xyuas, analogues thiab cov foos tso tawm (cov tshuaj insulin rau kev coj noj coj ua, hauv SoloStar, OptiSet thiab OptiKlik syringe cwj mem) tshuaj rau kev kho mob ntshav qab zib-insulin mellitus hauv cov laus, menyuam yaus thiab cev xeeb tub

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb Lauj TeebCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Lantus hauv lawv qhov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Lantus analogues pom muaj cov qauv txheej txheem zoo. Siv rau kev kho mob ntawm ntshav qab zib insulin-mellitus rau cov laus, menyuam yaus, nrog rau thaum lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Lauj Teeb - yog ib qho tshuaj noj ntawm tib neeg cov tshuaj insulin. Tau los ntawm kev rov ua kom zoo ntawm cov kab mob DNA ntawm hom Escherichia coli (E. coli) (K12 hom). Nws muaj cov qis qis solubility hauv qhov nruab nrab tsis zoo. Nyob rau hauv kev sib xyaw ntawm cov tshuaj Lantus, nws yog soluble kiag li, uas tau xyuas los ntawm acidic ib puag ncig ntawm kev daws rau kev txhaj tshuaj (pH = 4). Tom qab kev qhia txog cov roj ntsha subcutaneous, kev daws teeb meem, vim nws cov acidity, nkag mus rau hauv kev cuam tshuam qhov nruab nrab nrog kev tsim cov microprecipitates, los ntawm cov tshuaj insulin glargine me me (cov tshuaj nquag ntawm Lantus kev npaj) tau tas li tso tawm, muab qhov ncaj (tsis muaj peaks) profile ntawm qhov nkhaus-sijhawm nkhaus, nrog rau ntev lub sijhawm ua haujlwm ntawm cov tshuaj.

Qhov khi khi txuas rau cov tshuaj insulin rau ntawm insulin glargine thiab insulin tib neeg yog qhov zoo heev. Glulin insulin muaj cov roj ntsha zoo ib yam li cov insulin endogenous.

Qhov kev txiav txim siab tseem ceeb tshaj plaws ntawm insulin yog kev cai ntawm kev ua haujlwm ntawm cov piam thaj. Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib los ntawm kev ua kom cov piam thaj los ntawm qhov nqaij (tshwj xeeb cov leeg pob txha thiab cov nqaij mos), nrog rau qhov ua kom cov ntshav qabzib nyob hauv lub siab (gluconeogenesis). Cov tshuaj insulin inhibits adipocyte lipolysis thiab proteolysis, thaum ua kom cov protein synthesis zoo.

Lub sijhawm ncua ntev ntawm kev ua ntawm insulin glargine yog ncaj qha vim nws qhov qis qis nqus, uas tso cai rau cov tshuaj siv ib hnub ib zaug. Qhov pib ntawm kev ua ntawm qhov nruab nrab yog 1 teev tom qab sc tswj hwm. Qhov nruab nrab ntawm kev nqis tes yog 24 teev, qhov siab tshaj yog 29 teev. Qhov xwm ntawm kev ua ntawm insulin thiab nws cov analogues (piv txwv li, insulin glargine) dhau sijhawm tuaj yeem sib txawv ob leeg hauv cov neeg mob sib txawv thiab hauv tib tus neeg mob.

Lub sijhawm ntawm cov tshuaj Lantus yog vim nws qhov kev taw qhia rau hauv cov rog subcutaneous.

Muaj pes tsawg leeg

Insulin glargine + excipients.

Cov Tshuaj Pharmacokinetics

Kev sib piv kev kawm txog cov ntsiab lus ntawm cov tshuaj insulin glargine thiab insulin-isophan tom qab kev coj noj coj ua hauv ntshav cov ntshav hauv cov neeg noj qab haus huv thiab cov neeg mob ntshav qab zib mellitus qhia txog kev nqus qis dua thiab tseem ntev dua, nrog rau qhov tsis muaj lub siab tshaj plaws hauv insulin glargine piv nrog insulin-isofan.

Nrog s / c tswj hwm ntawm cov tshuaj 1 zaug hauv ib hnub, qhov nruab nrab ruaj khov ntawm cov tshuaj insulin glargine hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug.

Nrog kev tswj hwm intravenous, ib nrab-lub neej ntawm insulin glargine thiab tib neeg insulin yog qhov sib piv.

Hauv ib tus neeg nyob rau hauv cov roj ntsha subcutaneous, insulin glargine yog ib feem los ntawm carboxyl kawg (C-terminus) ntawm B saw (beta saw) tsim rau 21A-Gly-insulin thiab 21A-Gly-des-30B-Thr-insulin.Hauv ntshav, ob qho tib si tsis hloov pauv ntawm insulin glargine thiab nws cov khoom kom txav tau yooj yim.

Cov Khoom Qhia

mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj 6 xyoo,
mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj li 2 xyoos (rau SoloStar daim ntawv).

Tso Tawm Cov Ntawv

Kev daws rau kev tswj hwm subcutaneous (3 ml cartridges hauv OptiSet thiab OptiKlik syringe pens).

Ib qho kev daws teeb meem rau kev tswj hwm subcutaneous (3 ml cartridges hauv Lantus SoloStar syringe pens).

Cov lus qhia rau kev siv thiab tus qauv ntawm kev siv

Lantus OptiSet thiab OptiKlik

Qhov ntau npaum li cas ntawm cov tshuaj thiab lub sijhawm ntawm hnub rau nws cov kev tswj hwm tau teeb tsa ib leeg. Lantus siv tau subcutaneously ib hnub ib zaug, ib txwm nyob tib lub sijhawm. Lantus yuav tsum tau txhaj rau hauv cov roj hauv plab ntawm lub plab, xub pwg lossis ncej puab. Qhov chaw txhaj tshuaj yuav tsum tau hloov mus rau txhua txoj kev tswj hwm tshiab ntawm cov tshuaj hauv thaj chaw pom zoo rau kev tswj hwm sc ntawm cov tshuaj.

Cov tshuaj yuav siv tau ob qho tib si li monotherapy, thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic.

Thaum hloov mus rau tus neeg mob los ntawm insulins ntawm ntev lossis nruab nrab ntawm kev nqis tes ua rau Lantus, nws yuav tsim nyog los kho qhov tshuaj txhua hnub ntawm basal insulin lossis hloov cov tshuaj concomitant antidiabetic therapy (koob tshuaj thiab kev tswj hwm ntawm luv luv ua yeeb yam insulins lossis lawv cov analogues, nrog rau cov koob tshuaj ntawm qhov ncauj hypoglycemic).

Thaum hloov cov neeg mob los ntawm kev tswj hwm ob zaug ntawm insulin-isofan rau ib qho kev txhaj tshuaj ntawm Lantus, cov tshuaj txhua hnub ntawm basal insulin yuav tsum txo qis 20-30% hauv thawj lub lis piam ntawm kev kho mob kom txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab sawv ntxov. Nyob rau lub sijhawm no, qhov kev txo qis ntawm Lantus yuav tsum tau them nyiaj los ntawm kev nce ntxiv ntawm cov tshuaj insulin luv luv, tom qab ntawd los ntawm kev kho tus kheej rau cov koob tshuaj.

Ib yam li lwm yam tshuaj tiv thaiv kab mob rau tib neeg, cov neeg mob tau txais tshuaj ntau heev vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin tuaj yeem muaj qhov nce ntxiv ntawm cov lus teb rau insulin thaum hloov mus rau Lantus. Hauv cov txheej txheem hloov mus rau Lantus thiab hauv thawj lub lis piam tom qab nws, kev saib xyuas ntawm cov piam thaj hauv cov ntshav yog yuav tsum tau ua thiab, yog tias tsim nyog, kev kho ntawm kev tshaj tawm kev noj tshuaj ntawm insulin.

Nyob rau hauv cov ntaub ntawv ntawm kev txhim kho kev tswj ntawm cov metabolism thiab qhov tshwm sim ntau ntxiv hauv rhiab rau insulin, kev kho ntxiv ntawm kev siv tshuaj ntau dua tuaj yeem tsim nyog. Kev hloov kho koob tshuaj kuj tseem xav tau, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, lub sijhawm ntawm hnub rau kev tswj hwm tshuaj, lossis thaum muaj lwm yam tshwm sim uas ua rau muaj kev cuam tshuam rau kev txhim kho hypo- lossis hyperglycemia.

Cov tshuaj yuav tsum tsis txhob siv iv. Hauv / hauv kev qhia ntawm cov koob tshuaj ib txwm, npaj rau sc tswj hwm, tuaj yeem ua rau kev txhim kho ntshav nce siab ntau dhau.

Ua ntej kev tswj hwm, koj yuav tsum paub tseeb tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj.

Cov kev cai siv thiab tuav ntawm cov tshuaj

Ua ntej OptiSet syringe Cwjmem

Ua ntej siv, tshawb xyuas daim cartridge sab hauv daim ntawv xaum. Nws yuav tsum siv tsuas yog hais tias qhov kev daws teeb meem yog pob tshab, xim, tsis muaj qhov pom ntawm cov khoom thiab thiab zoo sib xws, cuam tshuam nrog dej. Lub khoob OptiSet syringe cwjmem tsis yog coj los siv thiab yuav tsum tau muab pov tseg.

Txhawm rau tiv thaiv kev sib kis, tus cwj mem uas muaj puv xaum xaum xaum siv los siv rau ib tus neeg mob nkaus xwb thiab tsis tuaj yeem xa mus rau lwm tus neeg.

Kev tuav cov OptiSet Syringe Cwj mem

Rau txhua zaus siv tom qab, ib txwm siv rab koob tshiab. Tsuas siv cov koob haum rau OptiSet koob txhaj tshuaj.

Ua ntej txhua txoj kev txhaj tshuaj, txoj kev kuaj kev nyab xeeb yuav tsum ua tas li.

Yog tias OptiSet koob txhaj tshuaj tshiab siv, kev npaj txhij rau kev siv yuav tsum tau nqa tawm uas siv 8 ntu ua ntej xaiv los ntawm cov khw.

Lub koob tshuaj xaiv tsuas tuaj yeem tig ib qho hauv ib qho kev taw qhia nkaus xwb.

Tsis txhob tig cov koob tshuaj xaiv (hloov cov tshuaj) tom qab nias lub pob tshuaj txhaj.

Yog tias lwm tus muab kev txhaj tshuaj rau tus neeg mob, yuav tsum tau saib xyuas tshwj xeeb kom tsis txhob raug mob rab koob thiab kev kis kab mob kis los ntawm kev kis kab mob.

Tsis txhob siv cov OptiSet koob txhaj tshuaj puas, zoo li yog muaj neeg tsis ntseeg.

Nws yog qhov tsim nyog kom muaj lub ntsej muag OptiSet syringe cwj mem thaum poob lossis puas tsuaj rau qhov siv.

Tom qab hle lub hau tawm los ntawm tus cwj mem syringe, kuaj cov cim ntawm tus pas dej insulin kom paub tseeb tias nws muaj cov tshuaj insulin txoj cai. Cov tsos ntawm cov tshuaj insulin kuj yuav tsum raug kuaj xyuas: cov kua dej hauv cov kua dej yuav tsum ua kom pom tseeb, xim, tsis pom cov khoom tawg thiab muaj qhov sib xws li dej. Tsis txhob siv OptiSet syringe cwj mem yog cov kua dej hauv cov kua dej khov, muaj xim lossis muaj cov txawv txawv.

Tom qab hle lub hau, ua tib zoo muab txoj hlua khi rau ntawm rab koob txhaj tshuaj.

Txheeb xyuas qhov kev npaj txhij ntawm cov xaum xaum xaum rau kev siv

Ua ntej txhua txoj kev txhaj tshuaj, nws yog qhov yuav tsum tau xyuas qhov npaj txhij ntawm rab koob xaum rau kev siv.

Rau tus cwj mem tsis siv tshiab thiab tsis siv, qhov ntsuas qhov ntsuas yuav tsum nyob rau tus lej 8, raws li tau teev tseg los ntawm cov khw.

Yog tias siv tus cwj mem syringe, lub tshuab xa tawm yuav tsum tig kom txog thaum lub ntsuas qhov ntsuas nres ntawm tus lej 2. Lub tshuab xa tawm yuav tig raws tsuas yog ib qho kev taw qhia.

Rub tawm lub pob pib lub taub hau nkaus rau qhov tshuaj. Tsis txhob tig cov koob xaiv rau tom qab lub khawm pib rub tawm.

Cov kaus mom uas siv sab nraud thiab sab hauv yuav tsum tau muab tshem tawm. Khaws lub hau npog sab hauv kom tshem tawm cov siv tau siv.

Tuav tus xaum xaum nrog rab koob taw tes sau taw sab saud, maj mam npuaj lub npuaj insulin nrog koj tus ntiv tes kom cua npuas sawv ntawm rab koob.

Tom qab ntawd, nias pib khawm pib ntua.

Yog tias qhov poob ntawm insulin raug tso tawm ntawm qhov taub ntawm rab koob, koob txhaj tshuaj thiab koob ua haujlwm kom raug.

Yog tias qhov poob ntawm cov tshuaj insulin tsis tshwm sim rau ntawm lub ntsis ntawm rab koob, koj yuav tsum rov ua qhov kev ntsuas tau npaj txhij ntawm rab koob xaum rau kev siv kom txog thaum cov insulin tshwm ntawm qhov taub ntawm rab koob.

Kev xaiv tshuaj insulin

Qhov koob tshuaj ntawm 2 units txog 40 units tuaj yeem tsim hauv nce ntxiv ntawm 2 units. Yog tias ib qho koob tshuaj ntau dua 40 units yuav tsum, nws yuav tsum raug txhaj nyob hauv ob lossis ntau dua kev txhaj tshuaj. Nco ntsoov tias koj muaj cov insulin txaus rau koj cov koob tshuaj.

Cov nplai ntawm cov tshuaj insulin nyob rau ntawm lub khob pob tshab rau cov tshuaj insulin qhia ntau npaum li cas cov tshuaj insulin nyob hauv OptiSet syringe cwj mem. Qhov ntsuas no tsis tuaj yeem siv los noj tshuaj insulin.

Yog hais tias lub piston dub yog thaum pib ntawm cov xim dawb lias, ces muaj kwv yees li 40 units ntawm insulin.

Yog hais tias lub qog dub yog qhov kawg ntawm cov kab dawb lias, tom qab ntawd muaj kwv yees li 20 units ntawm insulin.

Koob xaiv cov koob tshuaj yuav tsum tig kom txog rau thaum lub koob qhia tshuaj taw qhia yam xav tau.

Kev siv tshuaj insulin

Lub pob pib txhaj tshuaj yuav tsum tau rub mus rau hauv cov kev txwv sau cov insulin cwj mem.

Nws yuav tsum kuaj xyuas seb cov koob xav tau xav tau ntau ntau ntxiv. Lub pob pib hloov pauv raws li tus nqi ntawm cov tshuaj insulin seem hauv lub taub tshuaj insulin.

Lub pob pib tso cai rau koj los xyuas seb qhov tshuaj twg raug hu. Thaum qhov kev xeem, khawm pib yuav tsum tau ceev cia kom muaj zog. Qhov kawg pom ntawm cov kab dav ntawm lub khawm pib qhia txog tus nqi ntawm cov tshuaj insulin. Thaum pib khawm khawm, tsuas yog sab saum toj ntawm kab ntawv dav no pom.

Cov neeg qhia tshwj xeeb yuav tsum piav qhia txoj kev txhaj tshuaj rau tus neeg mob.

Lub koob txhaj yog txhaj subcutaneously. Lub pob pib txhaj tshuaj yuav tsum raug nias rau qhov txwv. Lub popping nyem yuav nres thaum txhaj pib pib nias rau txhua txoj kev. Tom qab ntawd, lub pob txhaj pib yuav tsum ceev rau hauv 10 vib nas this ua ntej rub rab koob tawm ntawm daim tawv nqaij. Qhov no yuav ua kom paub meej qhov pib ntawm tag nrho cov koob tshuaj insulin.

Tom qab txhua qhov kev txhaj tshuaj, rab koob yuav tsum tau muab tshem tawm ntawm koob txhaj tshuaj thiab muab pov tseg. Qhov no yuav tiv thaiv tus kab mob, nrog rau cov tshuaj insulin khiav tsis zoo, ua kom huab cua nkag tau thiab txhaws tau ntawm lub koob. Koob tsis tuaj yeem rov siv dua.

Tom qab ntawv, muab tso rau ntawm lub hau rau tus cwj mem syringe.

Cartridges yuav tsum tau siv ua ke nrog OptiPen Pro1 koob txhaj tshuaj, thiab raws li cov lus pom zoo los ntawm cov kws tsim khoom.

Cov lus qhia rau kev siv OptiPen Pro1 koob txhaj tshuaj hais txog lub thawv cartridge, kev sib txuas ntawm rab koob, thiab kev txhaj tshuaj insulin yuav tsum tau ua raws nraim. Tshawb xyuas daim cartridge ua ntej siv. Nws yuav tsum tau siv tsuas yog daws tau qhov tseeb, tsis muaj xim thiab tsis muaj cov khoom pom zoo. Ua ntej kev txhim kho lub taub hauv ntawv hauv lub phwj hauv cov thawv, yuav tsum tau ua daim cartridge yuav tsum nyob ntawm chav sov li 1-2 teev. Ua ntej txhaj, tshem cov pa npuas los ntawm daim cartridge. Nws yog ib qho tsim nyog yuav tau nruj me ntsis raws li cov lus qhia. Lub pob txha mos tas tsis rov qab siv dua. Yog tias OptiPen Pro1 syringe mem yog puas lawm, koj yuav tsum tsis txhob siv nws.

Yog tias rab koob xaum hluav taws xob muaj qhov yuam kev, yog tias tsim nyog, tshuaj insulin tuaj yeem muab rau tus neeg mob los ntawm kev sau cov tshuaj los ntawm daim cartridge rau hauv cov yas koob txhaj tshuaj (tsim nyog rau cov tshuaj insulin ntawm qhov siab ntawm 100 IU / ml).

Txhawm rau tiv thaiv kev kis mob, tsuas yog ib tus neeg yuav tsum siv tus cwj mem uas siv rov siv tau.

Optical Nyem Cartridge System

Lub OptiClick cartridge system yog lub khob ntim uas muaj 3 ml ntawm insulin glargine tov, uas tau muab tso rau hauv cov pob tshab yas ntim nrog lub twj tso kua mis.

OptiClick cartridge system yuav tsum tau siv nrog OptiClick syringe cwj mem raws li cov lus qhia rau kev siv uas tuaj nrog nws.

Tag nrho cov lus pom zoo muaj nyob hauv cov lus qhia rau kev txhim kho lub taub ntim hauv OptiClick syringe mem, txuas cov koob, thiab txhaj tshuaj yuav tsum ua raws nraim li kev cai.

Yog tias OptiClick syringe cwj mem puas lawm, hloov nws nrog tus tshiab.

Ua ntej kev txhim kho lub thawv ntim hauv OptiClick syringe mem, nws yuav tsum nyob ntawm chav tsev li 1-2 teev. Lub cartridge system yuav tsum kuaj xyuas ua ntej kev teeb tsa. Nws yuav tsum tau siv tsuas yog daws tau qhov tseeb, tsis muaj xim thiab tsis muaj cov khoom pom zoo. Ua ntej txhaj tshuaj, tshem cov pa npuas los ntawm daim cartridge system (zoo li yog siv rab koob xwj). Lub cav ntim cov nplauv tsis tau rov qab siv dua.

Yog tias rab koob xaum hluav taws xob muaj qhov yuam kev, yog tias tsim nyog, tshuaj insulin tuaj yeem muab rau tus neeg mob los ntawm kev ntaus cov tshuaj los ntawm daim cartridge rau hauv cov yas koob txhaj tshuaj (haum rau cov tshuaj insulin ntawm qhov siab ntawm 100 IU / ml).

Txhawm rau tiv thaiv kev kis mob, tsuas yog ib tus neeg yuav tsum siv tus cwj mem uas siv rov siv tau.

Lantus SoloStar yuav tsum tau txhaj tshuaj subcutaneously ib zaug hauv ib hnub ntawm txhua lub sijhawm ntawm hnub, tab sis txhua hnub nyob rau tib lub sijhawm.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus SoloStar tuaj yeem siv ob qho tib si li monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic. Cov hom phiaj tseem ceeb ntawm cov piam thaj hauv cov ntshav, nrog rau cov koob tshuaj thiab lub sijhawm ntawm kev tswj hwm lossis kev tswj hwm ntawm cov tshuaj hypoglycemic yuav tsum txiav txim siab thiab kho tus kheej.

Kev hloov kho koob tshuaj kuj tseem yuav tsum tau ua, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, hloov lub sijhawm ntawm kev saib xyuas ntawm lub koob tshuaj insulin, lossis lwm qhov xwm txheej uas yuav ua rau muaj kev cuam tshuam rau kev txhim kho hypo- lossis hyperglycemia. Txhua qhov kev hloov pauv ntawm cov koob tshuaj insulin yuav tsum tau ua nrog ceev faj thiab kev saib xyuas mob.

Lantus SoloStar tsis yog cov insulin ntawm kev xaiv rau kev kho mob ntshav qab zib ketoacidosis. Hauv qhov no, kev nyiam yuav tsum tau muab rau hauv / hauv kev qhia luv luv ntawm kev ua yeeb yam insulin. Hauv cov txheej txheem kho mob suav nrog kev txhaj tshuaj insal basal thiab prandial insulin, 40-60% ntawm cov tshuaj insulin txhua hnub hauv daim ntawv ntawm insulin glargine feem ntau yog siv kom tau raws li qhov xav tau ntawm insulin basal.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus noj tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj, kev sib xyaw ua ke pib nrog ib koob tshuaj insulin glargine 10 PIECES 1 zaug hauv ib hnub thiab hauv kev kho mob tom ntej yog kho tus kheej.

Hauv txhua tus neeg mob ntshav qab zib, soj ntsuam cov ntshav qabzib hauv siab pom zoo.

Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic mus rau Lantus SoloStar

Thaum hloov cov neeg mob los ntawm cov txheej txheem kev kho mob uas siv cov tshuaj ntev nruab nrab lossis kev siv tshuaj ntev los rau kev kho mob uas siv Lantus SoloStar kev npaj, nws yuav tsim nyog kho tus naj npawb (koob tshuaj) thiab lub sijhawm ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin lossis nws cov tshuaj noj thaum nruab hnub lossis hloov cov tshuaj ntawm qhov ncauj hypoglycemic tshuaj.

Thaum hloov cov neeg mob los ntawm ib qho kev txhaj tshuaj ntawm cov tshuaj insulin-isofan nyob rau ib hnub rau ib txoj kev tswj hwm ntawm cov tshuaj thaum nruab hnub, Lantus SoloStar feem ntau tsis hloov pauv thawj zaug ntawm insulin (i.e., qhov ntau npaum li cas ntawm cov tshuaj Lantus SoloStar Cov Hnub ib hnub yog sib npaug nrog cov nyiaj ntawm ME insulin isofan ib hnub).

Thaum hloov cov neeg mob los ntawm kev siv tshuaj insulin-isophan ob zaug thaum nruab hnub rau ib qho kev txhaj tshuaj ntawm Lantus SoloStar ua ntej yuav mus pw kom txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab thaum sawv ntxov ntxov, qhov kev txhaj tshuaj insulin glargine txhua hnub feem ntau raug txo qis 20% (piv nrog qhov tshuaj ntawm txhua hnub ntawm insulin) isophane), thiab tom qab ntawd nws raug kho nyob ntawm lub teb ntawm tus neeg mob.

Lantus SoloStar yuav tsum tsis txhob sib xyaw lossis xyaw nrog lwm cov tshuaj insulin. Nco ntsoov tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj. Thaum muab sib xyaw los yog zom, qhov profile ntawm insulin glargine yuav hloov lub sijhawm.

Thaum hloov los ntawm tib neeg cov insulin rau Lantus SoloStar thiab thaum thawj lub lis piam tom qab nws, ua tib zoo saib xyuas kev ntsuas metabolic (saib xyuas cov ntshav qabzib hauv cov ntshav) nyob rau hauv kev saib xyuas mob tau pom zoo, nrog kev kho cov tshuaj ntau ntxiv ntawm cov insulin yog tias tsim nyog. Ib yam li lwm cov duab ntawm tib neeg cov tshuaj insulin, qhov no tshwj xeeb tshaj yog rau cov neeg mob, vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin, yuav tsum tau siv cov koob tshuaj ntau kawg ntawm tib neeg cov insulin. Hauv cov neeg mob no, thaum siv cov tshuaj insulin glargine, muaj kev txhim kho tseem ceeb rau cov tshuaj tiv thaiv kab mob insulin.

Nrog kev txhim kho metabolic kev tswj tau thiab qhov tshwm sim hauv kev hloov pauv nqaij hauv insulin mus rau insulin, nws yuav tsim nyog los kho qhov tshuaj ntau npaum li cas ntawm cov tshuaj insulin.

Kev sib xyaw thiab kev tsim tsiaj

Cov tshuaj Lantus SoloStar yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulins. Kev sib xyaw ua ke tuaj yeem hloov qhov sib piv ntawm lub sij hawm / siv cov tshuaj Lantus SoloStar, thiab tseem ua rau dej nag.

Cov pab pawg neeg tshwj xeeb

Cov tshuaj Lantus SoloStar tuaj yeem siv rau hauv cov menyuam yaus hnub nyoog ntau dua 2 xyoos. Siv rau cov menyuam yaus hnub nyoog qis dua 2 xyoos tsis tau kawm.

Hauv cov neeg laus cov neeg mob ntshav qab zib mellitus, nws raug nquahu kom siv cov koob tshuaj me ntsis, lawv qhov nce qeeb thiab siv cov koob tshuaj tiv thaiv mob pes tsawg.

Cov tshuaj Lantus SoloStar raug muab tshuaj ua ib qho sc txhaj tshuaj. Cov tshuaj Lantus SoloStar tsis yog tsim rau kev tswj hwm pob ntseg.

Lub sijhawm ntev ntawm kev ua ntawm insulin glargine yog pom tsuas yog thaum nws qhia rau hauv cov rog subcutaneous. Hauv / hauv kev qhia ntawm cov tshuaj subcutaneous li niaj zaus tuaj yeem ua rau mob ntshav qab zib heev. Lantus SoloStar yuav tsum tau nkag mus rau hauv cov roj ntsha hauv qab ntawm lub plab, xub pwg lossis lub duav. Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv nrog txhua qhov kev txhaj tshuaj tshiab hauv thaj chaw pom zoo rau kev tswj hwm sc ntawm cov tshuaj. Xws li lwm hom tshuaj insulin, qhov siab ntawm kev nqus, thiab, yog li ntawd, qhov pib thiab lub sijhawm ntawm nws qhov kev ua, tuaj yeem sib txawv raws li tus yam ntxwv ntawm lub cev thiab lwm yam kev hloov pauv ntawm tus neeg mob lub cev.

Lantus SoloStar yog cov kev daws teeb meem, tsis raug ncua. Yog li ntawd, rov kho dua ua ntej siv tsis tas. Yog tias cov koob txhaj tshuaj Lantus SoloStar ua haujlwm tsis zoo, cov tshuaj insulin glargine tuaj yeem tshem tawm los ntawm daim cartridge mus rau hauv cov koob txhaj tshuaj (haum rau cov tshuaj insulin 100 IU / ml) thiab ua kom tsim nyog txhaj.

Cov cai rau siv thiab tuav ntawm cov ntawv ua ntej ua tiav cov kua mem SoloStar

Ua ntej siv thawj zaug, rab koob xaum xaum yuav tsum khaws cia ntawm chav tsev li 1-2 teev.

Lub cev tsis siv SoloStar lub koob txhaj tshuaj yuav tsum tsis txhob siv thiab muab pov tseg.

Txhawm rau tiv thaiv kev kis mob, tus cwj mem uas muaj menyuam qhwv ua ntej tsuas yog siv los ntawm ib tus neeg mob thiab yuav tsum tsis txhob hloov mus rau lwm tus.

Ua ntej siv SoloStar koob txhaj tshuaj, ua tib zoo nyeem cov ntaub ntawv ntawm kev siv.

Ua ntej siv txhua qhov, ua tib zoo txuas lub koob tshiab rau daim duab xaum xaum thiab kev sim kev nyab xeeb. Tsuas siv cov koob uas txuam nrog SoloStar yuav tsum siv.

Cov kev tiv thaiv tshwj xeeb yuav tsum tau ceev faj kom tsis txhob muaj kev sib tsoo nrog kev siv koob thiab qhov kis tau ntawm kev kis tus kab mob.

Tsis muaj qhov xwm txheej twg yog koj yuav tsum siv SoloStar syringe cwj mem yog tias nws puas lawm lossis yog tias koj tsis paub meej tias nws yuav ua haujlwm tau zoo.

Koj yuav tsum nco ntsoov muaj SoloStar koob txhaj tshuaj muaj nyob rau hauv yog tias poob lossis puas rau ib tus cwj mem SoloStar uas twb muaj lawm.

Yog tias SoloStar syringe cwj mem tau muab cia rau hauv lub tub yees, nws yuav tsum tau ua tawm 1-2 teev ua ntej qhov kev txhaj tshuaj kom cov tshuaj ua kom sov hauv chav. Kev tswj hwm cov tshuaj chine chilled yog qhov mob ntau dua. Kev siv SoloStar syringe cwj mem yuav tsum tau muab pov tseg.

SoloStar syringe mem yuav tsum muaj kev tiv thaiv los ntawm hmoov av thiab av. Sab sab nraud ntawm SoloStar koob txhaj tshuaj tuaj yeem muab ntxuav los ntawm kev so nws nrog daim ntaub ntub dej. Tsis txhob raus dej hauv cov kua, yaug thiab ntub dej SoloStar syringe cwj mem, vim tias qhov no tuaj yeem ua rau nws puas.

SoloStar koob txhaj tshuaj yog txhaj tshuaj insulin kom raug thiab nyab xeeb siv. Nws tseem yuav tsum tau ua tib zoo saib xyuas. Zam cov xwm txheej uas ua puas rau SoloStar koob txhaj tshuaj yuav tshwm sim. Yog tias koj xav tias muaj kev puas tsuaj rau SoloStar syringe cwj mem uas twb muaj lawm, siv tus xaum xim tshiab.

Theem 1. Tshuaj Insulin

Koj yuav tsum kos cov ntawv lo rau ntawm SoloStar syringe cwj mem kom ntseeg tau tias nws muaj cov tshuaj insulin txoj cai. Rau Lantus, SoloStar koob txhaj tshuaj yog grey nrog lub khawm xiav rau txhaj. Tom qab hle lub hau ntawm rab koob txhaj tshuaj, cov tsos ntawm cov tshuaj insulin nyob hauv nws yog tswj: cov tshuaj insulin yuav tsum muaj pob tshab, tsis muaj xim, tsis muaj cov khoom ua kom pom thiab zoo li dej nyob hauv xwm yeem.

Theem 2. Txuas rab koob

Tsuas yog siv cov koob uas txuam nrog SoloStar koob txhaj tshuaj yuav tsum tau siv.Txog kev txhaj txhua zaus, yuav tsum siv rab koob tshiab tshiab uas tsis huv. Tom qab hle lub hau tawm, rab koob yuav tsum tau muab ntsia kom zoo ntawm daim duab syringe.

Theem 3. Ua qhov ntsuas kev nyab xeeb

Ua ntej txhua txoj kev txhaj tshuaj, nws yog qhov yuav tsum tau ua qhov kev ntsuas kev nyab xeeb thiab ua kom cov koob txhaj tshuaj ua haujlwm zoo thiab cua tshuab tau tshem tawm.

Ntsuas ib koob tshuaj sib npaug rau 2 ntsuas.

Cov kaus mom uas siv sab nraud thiab sab hauv yuav tsum tau muab tshem tawm.

Muab tus cwj mem ntim nrog rab koob tso tawm, maj mam coj mus rhaub cov insulin lub taub hau nrog koj tus ntiv tes kom txhua npuas pa mus rau rab koob.

Tag nrho nias lub pob txhaj.

Yog tias muaj cov tshuaj insulin rau ntawm qhov kawg ntawm rab koob, qhov no txhais tau tias rab koob xaum thiab rab koob ua hauj lwm zoo.

Yog tias cov tshuaj insulin tsis tshwm sim rau ntawm lub ntsis ntawm rab koob, tom qab ntawd cov kauj ruam 3 tuaj yeem rov ua dua kom txog thaum insulin tshwm ntawm lub taub ntawm rab koob.

Theem 4. Xaiv Xaiv

Cov koob tshuaj tuaj yeem tsim nrog qhov tseeb ntawm 1 unit los ntawm koob tshuaj yam tsawg kawg nkaus (1 units) txog qhov siab tshaj plaws (80 units). Yog tias nws yog qhov yuav tsum tau qhia qhov tshuaj tshaj li ntawm 80 units, yuav tsum txhaj 2 lossis ntau dua kev txhaj tshuaj.

Lub khob ntim tshuaj yuav tsum qhia "0" tom qab kev ntsuas kev nyab xeeb tiav. Tom qab ntawd, cov koob tshuaj tsim nyog tau tsim muaj.

Theem 5. Ceeb Toom

Tus neeg mob yuav tsum tau qhia rau cov txheej txheem txhaj tshuaj los ntawm tus kws kho mob paub.

Lub koob yuav tsum tau muab tso rau hauv qab daim tawv nqaij.

Lub pob txhaj tshuaj yuav tsum nias tag nrho. Nws tau tuav hauv txoj haujlwm no rau 10 feeb ntxiv kom txog thaum muab rab koob tshem tawm. Qhov no ua kom paub tseeb ntawm qhov kev xaiv ntawm xaiv koob tshuaj insulin kiag li.

Theem 6. Tshem thiab tshem tawm ntawm rab koob

Txhua qhov xwm txheej, rab koob tom qab txhua txoj kev txhaj tshuaj yuav tsum tau muab tshem tawm thiab muab pov tseg. Qhov no ua kom muaj kev tiv thaiv ntawm kev sib kis thiab / lossis kis tau tus mob, cua nkag mus rau hauv lub thawv rau tshuaj insulin thiab paim ntshav ntawm insulin.

Thaum hle thiab pov tseg lub koob, yuav tsum muaj kev tiv thaiv tshwj xeeb. Ua raws li kev tiv thaiv kev nyab xeeb pom zoo kom tshem tawm thiab ntuav tawm rab koob (piv txwv, cov txheej txheem tes ib leeg) txhawm rau txo kev pheej hmoo ntawm kev phom sij ntsig txog rab koob thiab tiv thaiv ua mob.

Tom qab hle rab koob, kaw lub SoloStar syringe cwj mem nrog lub hau.

Sab sij huam

hypoglycemia - muaj kev txhim kho feem ntau yog tias cov koob tshuaj insulin ntau dua qhov xav tau rau nws,
"twilight" nco qab lossis nws poob,
mob huam
kev tshaib kev nqhis
txob taus
hws no
tachycardia
pom kev pom
retinopathy
ua yeeb yaj kiab
mob siab,
myalgia
o tuaj
cov tshuaj tiv thaiv tam sim ntawd rau tshuaj insulin (suav nrog insulin glargine) lossis cov tshuaj tiv thaiv cov tshuaj: cov tawv nqaij tsis haum rau lub cev, cov tshuaj tiv thaiv mob hlwb, mob ntsws, mob ntsws, mob ntshav hauv lub plawv, poob siab,
liab, mob, khaus, khaus, o lossis o ntawm thaj chaw txhaj tshuaj.

Cov Yuav Tsum Tau Ua

cov me nyuam qis dua 6 xyoo rau Lantus OptiSet thiab OptiKlik (tam sim no tsis muaj cov ntaub ntawv tshawb fawb txog kev siv),
cov menyuam yaus lub hnub nyoog txog 2 xyoos rau Lantus SoloStar (tsis muaj cov ntaub ntawv tshawb fawb txog kev siv),
ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Nrog kev ceev faj, Lantus yuav tsum siv thaum cev xeeb tub.

Rau cov neeg mob uas muaj ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj cov kev cai metabolic txaus thoob plaws lub cev xeeb tub. Hauv lub caij nyoog thib ib ntawm cev xeeb tub, xav tau cov tshuaj insulin yuav txo qis, hauv kev txiav thib 2 thiab thib 3 nws yuav nce ntxiv. Tam sim ntawd tom qab yug menyuam tas, xav tau cov tshuaj insulin tsawg dua, thiab yog li qhov kev pheej hmoo ntawm kev mob ntshav qab zib nce ntxiv. Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Hauv kev sim tsiaj, tsis muaj cov ntaub ntawv ncaj qha los yog tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine.

Tseem tsis tau muaj kev tswj hwm qhov kev soj ntsuam ntawm kev nyab xeeb ntawm cov tshuaj Lantus thaum cev xeeb tub. Muaj pov thawj ntawm kev siv Lantus hauv 100 tus poj niam cev xeeb tub muaj ntshav qab zib. Cov chav kawm thiab kev tshwm sim ntawm cev xeeb tub hauv cov neeg mob no tsis txawv ntawm cov poj niam cev xeeb tub uas muaj ntshav qab zib uas tau txais lwm yam tshuaj insulin.

Rau cov poj niam thaum lub sijhawm pub niam mis, yuav tsum muaj kev kho mob ntawm cov tshuaj insulin kom zoo thiab kev noj zaub mov kom zoo.

Siv rau menyuam yaus

Tam sim no tsis muaj cov ntaub ntawv tshawb fawb txog kev siv hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Siv rau cov neeg mob laus

Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum ua haujlwm tuaj yeem ua rau cov insulin txuas ntxiv kom tsawg.

Cov lus qhia tshwj xeeb

Lantus tsis yog cov tshuaj ntawm kev xaiv rau kev kho mob ntshav qab zib ketoacidosis. Hauv cov xwm txheej zoo li no, kev pom zoo ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin.

Vim tias qhov kev siv tsawg nrog Lantus, nws tsis muaj peev xwm los soj ntsuam nws cov hauj lwm zoo thiab kev nyab xeeb hauv kev kho cov neeg mob uas lub siab tsis ua hauj lwm lossis cov neeg mob uas tsis txaus los yog lub raum tsis txaus.

Hauv cov neeg mob uas lub raum khiav tsis zoo, qhov xav tau cov tshuaj insulin tuaj yeem txo qis vim qhov ua kom tsis muaj zog ntawm nws cov txheej txheem tshem tawm. Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum ua haujlwm tuaj yeem ua rau cov insulin txuas ntxiv kom tsawg.

Hauv cov neeg mob uas muaj kev tiv thaiv kabmob hepatic txaus, qhov kev xav tau rau insulin tuaj yeem raug txo vim muaj kev txo qis hauv kev muaj peev xwm gluconeogenesis thiab biotransformation ntawm insulin.

Kev tswj hwm qhov tsis zoo ntawm cov theem ntawm cov piam thaj hauv cov ntshav, zoo li yog tias muaj kev nyiam los txhim kho hypo- lossis hyperglycemia, ua ntej taug kev nrog kev txhim kho ntawm kev noj tshuaj, nws yog qhov yuav tsum tau kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem kev kho mob, qhov chaw ntawm kev tswj hwm tshuaj thiab cov txheej txheem ntawm kev tsim nyog sc txhaj tshuaj. , xav txog txhua yam cuam tshuam rau nws.

Lub sijhawm ntawm kev txhim kho hypoglycemia yog nyob ntawm qhov profile ntawm kev ua ntawm kev siv tshuaj insulin thiab yuav, yog li ntawd, hloov nrog qhov hloov pauv ntawm kev kho mob. Vim tias qhov nce ntxiv hauv lub sijhawm nws yuav siv rau kev tswj hwm ntawm cov insulin ntev ntev thaum siv Lantus, ib qho yuav tsum cia siab tias yuav muaj qhov qis dua ntawm kev txhim kho nocturnal hypoglycemia, thaum ntxov thaum lub sijhawm sawv ntxov qhov kev cia siab yuav siab dua. Yog tias hypoglycemia tshwm sim hauv cov neeg mob tau txais Lantus, muaj peev xwm ua rau kev tawm qeeb los ntawm hypoglycemia vim yog lub sijhawm ntev ua ntawm insulin glargine yuav tsum raug txiav txim siab.

Hauv cov neeg mob uas ua rau lub sijhawm mob ntshav qab zib tsawg yuav muaj tej yam tseem ceeb hauv kev soj ntsuam, suav nrog nrog kev mob hnyav ntawm cov hlab ntshav ntawm lub plawv lossis cov hlab ntsha hauv hlab ntsha (muaj kev pheej hmoo ntawm kev mob plawv thiab cov ntshav ntawm lub qog ntshav qab zib), nrog rau cov neeg mob uas muaj kev phom sij loj dua, tshwj xeeb tshaj yog tias lawv tsis tau txais kev kho mob photocoagulation (muaj kev pheej hmoo tsis pom kev vim tias muaj ntshav qab zib), yuav tsum tau ceev faj tshwj xeeb ntshav qab zib.

Cov neeg mob yuav tsum tau ceeb toom txog cov xwm txheej uas cov tsos mob ua ntej ntawm lub qog ntshav qab zib yuav txo qis, tsis hais tawm los yog tsis tuaj rau hauv qee pawg muaj kev pheej hmoo, uas suav nrog:

cov neeg mob uas tau pom muaj kev hloov kho cov kev cai ntawm cov ntshav piam thaj,
cov neeg mob uas mob ntshav qab zib tsawg zuj zus
cov neeg laus laus
cov neeg mob neuropathy
cov neeg mob uas muaj ntshav qab zib ntev,
cov neeg mob mob hlwb
cov neeg mob hloov los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg insulin,
cov neeg mob tau txais kev kho mob nrog lwm yam tshuaj.

Cov xwm txheej zoo li no tuaj yeem ua rau muaj kev nce siab ntawm qhov mob ntshav qab zib tsawg (nrog rau qhov ua rau tsis nco qab) ua ntej tus neeg mob paub tseeb tias nws muaj kev mob ntshav qab zib tsawg.

Yog tias muaj qhov qis lossis qis glycated hemoglobin qib raug sau tseg, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus lej muaj peev xwm tsim rov tshwm sim tsis paub lub sijhawm ntawm hypoglycemia (tshwj xeeb tshaj yog thaum tsaus ntuj).

Cov neeg mob ua raws li kev noj tshuaj, kev noj haus, thiab kev noj haus, kev siv tshuaj insulin kom raug, thiab tswj kev pib ntawm cov tsos mob ntawm lub qog ntshav qab zib ua rau txo qis tseem ceeb ntawm qhov kev pheej hmoo ntawm hypoglycemia. Nyob rau hauv lub xub ntiag ntawm yam uas ua rau kom cov kev xav rau lub cev tsis zoo, tshwj xeeb tshaj yog saib xyuas yog qhov tsim nyog, vim hais tias Yuav tsum tau txhaj tshuaj insulin ntau npaum li cas. Tej yam no suav nrog:

hloov chaw ntawm kev tswj hwm ntawm insulin,
nce rhiab rau insulin (piv txwv li, thaum tshem tawm cov kev ntxhov siab),
txawv txav, nce lossis ntev heev ntawm kev ua lub cev,
cov kab mob sib xyaw nrog los ntuav, raws plab,
ua txhaum kev noj haus thiab kev noj haus,
hla kev noj haus
haus cawv
qee qhov ua tsis tiav ntawm cov tshuaj endocrine (piv txwv li, hypothyroidism, tsis txaus ntawm adenohypophysis lossis adrenal cortex),
muaj kev sib txuam nrog lwm yam tshuaj.

Hauv cov kabmob uas cuam tshuam, yuav tsum muaj kev tswjhwm ntau dua ntawm cov ntshav piam thaj. Feem ntau, kev txheeb xyuas yog ua rau muaj cov ketone lub cev nyob hauv cov zis, thiab kev kho ntawm cov tshuaj ntau npaum li cas ntawm cov tshuaj insulin kuj tseem xav tau. Qhov kev xav tau rau insulin feem ntau nce. Cov neeg mob ntshav qab zib hom 1 yuav tsum txuas ntxiv kev haus tsawg kawg, txawm tias noj tsawg tsawg txawm muaj tsawg los sis tsis muaj peev xwm noj, nrog rau ntuav. Cov neeg mob no yuav tsum tsis txhob tso tseg txoj kev siv tshuaj insulin.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj tiv thaiv kab mob rau hauv lub cev, ACE inhibitors, disopyramides, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, dextropropoxyphene, salicylates thiab sulfonamide antimicrobials tuaj yeem txhim kho hypoglycemic nyhuv ntawm insulin thiab nce qhov kev txhawb nqa rau kev txhim kho hypoglycemia. Nrog rau cov kev sib txuas ua ke no, yuav tsum tau muaj kev kho kom haum ntawm cov tshuaj insulin glargine.

Glucocorticosteroids (GCS), danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, phenothiazine derivatives, somatotropin, sympathomimetics (e.g. epinephrine, salbutamol, terbutaline), cov thyroid hormones, clintazepine inhibitors, qee yam ) tej zaum yuav txo cov nyhuv hypoglycemic ntawm insulin. Nrog rau cov kev sib txuas ua ke no, yuav tsum tau muaj kev kho kom haum ntawm cov tshuaj insulin glargine.

Nrog tib lub sijhawm siv cov tshuaj Lantus nrog cov beta-blockers, clonidine, lithium ntsev, ethanol (cawv), ob qho tib si ntxiv dag zog thiab qaug zog ntawm cov nyhuv hypoglycemic ntawm insulin yog ua tau. Pentamidine thaum ua ke nrog cov tshuaj insulin tuaj yeem ua rau hypoglycemia, uas yog qee zaum hloov los ntawm hyperglycemia.

Nrog rau kev siv ua ke nrog cov tshuaj nrog cov nyhuv sympatholytic, xws li beta-blockers, clonidine, guanfacine thiab reserpine, qhov txo qis lossis tsis muaj cov cim ntawm adrenergic counterregulation (kev ua kom zoo ntawm cov leeg hlwb) nrog kev txhim kho hypoglycemia yog ua tau.

Daim roj pleev tsis tas yuav tsum muab sib xyaw nrog lwm cov tshuaj insulin, nrog rau lwm yam tshuaj, lossis diluted. Thaum muab sib xyaw los yog zom, qhov profile ntawm nws qhov kev txiav txim siab yuav hloov zuj zus, ntxiv rau, kev sib xyaw nrog lwm cov insulins tuaj yeem ua rau nag lossis daus.

Cov tshuaj ntawm cov tshuaj Lantus

Cov qauv ntawm cov qauv ua haujlwm:

Tshuaj insulin glargine,
Xaus SoloStar.

Cov tshuaj piv rau qhov ua kom ua tau zoo (tshuaj rau kev kho mob ntawm cov tshuaj ntshav qab zib insulin mellitus):

Actrapid
Tus tub sab
Apidra
B. TshuajTus Kab
Berlinulin,
Biosulin
Glyformin
Glucobay,
Qov tshuaj insulin C,
Dibikor
Isofan Insulin Ntiaj Teb Khob,
Iletin
Tshuaj Insulin Isofanicum,
Cov ntaub thaiv insulin,
Tshuaj insulin Maxirapid B,
Insulin soluble nruab nrab
Insulin semilent,
Cov tshuaj Insulin Ultralente,
Cov tshuaj insulin ntev
Tshuaj insulin Ultralong,
Neeg tsis ntseeg xav
Mob siab
Siv cov tshuaj insulin C
Levemir Penfill,
Levemir Flexpen,
Metformin
Mikstard
Monosuinsulin MK,
Monotard
NovoMiks,
NovoRapid,
Pensulin,
Protafan
Rinsulin
Tshuaj Stylamine
Torvacard
Tricor
Ntshaw Txiv Neej
Neej Neeg,
Neeg lim hiam
Cigapan
Erbisol.

Pharmacological kev txiav txim

Cov tshuaj insulin glargine yog cov tshuaj insulin ntev ntev tau los ntawm kev rov ua kom zoo ntawm DNA cov kab mob ntawm cov hom Escherichia coli (hom K12). Nws muaj cov qis qis solubility hauv qhov nruab nrab tsis zoo. Raws li ib feem ntawm Lantuso SoloStar ® kev npaj, nws yog kev ua kom tiav, uas yog ua kom muaj cov kua qaub-paug ib puag ncig ntawm cov tshuaj txhaj (pH = 4). Tom qab kev qhia txog cov roj ntsha subcutaneous, txoj kev daws teeb meem, vim nws cov acidity, nkag mus rau hauv kev cuam tshuam nruab nrab nrog kev tsim cov microprecipitates, los ntawm cov tshuaj insulin glargine tso tawm tas li, muab ib qho ncaj (tsis muaj peaks) profile ntawm qhov siab-lub sijhawm nkhaus, nrog rau lub sijhawm ntev ntawm cov tshuaj.

Qhov kev khi khi rau cov kab mob insulin txais ntawm insulin glargine thiab insulin tib neeg yog qhov zoo heev, yog li ntawd, insulin glargine muaj cov roj ntsha zoo ib yam li cov insulin endogenous.

Lub sijhawm ua haujlwm ntev ntawm insulin glargine yog ncaj qha vim qhov txo qis ntawm nws txoj kev nqus, uas tso cai rau koj siv cov tshuaj 1 lub sijhawm / Tom qab kev tswj hwm sc, qhov pib ntawm nws qhov kev ua haujlwm raug soj ntsuam, nyob rau nruab nrab, tom qab 1 teev. Lub sijhawm nruab nrab ntawm kev ua yog 24 teev, qhov siab tshaj plaws yog 29 teev. thiab nws cov analogues (piv txwv li, insulin glargine) tuaj yeem sib txawv hauv ob qho tib si rau cov neeg mob sib txawv thiab hauv tib tus neeg mob.

Cov Tshuaj Pharmacokinetics

Kev sib piv kev kawm txog cov ntsiab lus ntawm cov tshuaj insulin glargine thiab insulin-isofan tom qab cov thawj coj hauv cov ntshav ntawm cov neeg noj qab haus huv thiab cov neeg mob ntshav qab zib tau qhia qeeb dua thiab qeeb dua ntev dua, nrog rau qhov tsis muaj lub siab tshaj plaws hauv insulin glargine piv rau insulin-isofan.

Nrog kev tswj hwm ntawm cov tshuaj subcutaneous 1 zaug nyob rau ib hnub, qhov nruab nrab ruaj khov ntawm cov tshuaj insulin glargine hauv cov ntshav tau tiav tom qab 2-4 hnub ntawm kev tswj hwm txhua hnub.

Nrog rau / hauv cov lus qhia ntawm T1 / 2 insulin glargine thiab insulin tib neeg yog qhov sib piv.

Hauv ib tus neeg nyob rau hauv cov roj ntsha subcutaneous, insulin glargine yog ib feem los ntawm carboxyl kawg (C-terminus) ntawm B saw (beta saw) tsim rau 21A-Gly-insulin thiab 21A-Gly-des-30B-Thr-insulin. Hauv ntshav, ob qho tib si tsis hloov pauv ntawm insulin glargine thiab nws cov khoom kom txav tau yooj yim.

Kev noj tshuaj ntxiv

Rau cov neeg laus thiab menyuam yaus hnub nyoog dhau 6 xyoo, cov tshuaj tau txhaj tshuaj tsawg dua 1 zaug hauv ib hnub, ib txwm tib lub sijhawm. Lantus® SoloStar® yuav tsum tau txhaj rau cov roj hauv qab plab, xub pwg lossis ncej puab. Qhov chaw txhaj tshuaj yuav tsum tau hloov mus rau txhua txoj kev tswj hwm tshiab ntawm cov tshuaj hauv thaj chaw pom zoo rau kev tswj hwm ntawm cov tshuaj.

Qhov ntau npaum li cas ntawm cov tshuaj thiab lub sijhawm ntawm hnub rau nws cov kev tswj hwm tau teeb tsa ib leeg.Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus® SoloStar® tuaj yeem siv ob qho tib si li monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic.

Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic rau Lantus® SoloStar®

Thaum hloov mus rau tus neeg mob los ntawm kev ntev ntev lossis nruab nrab ntawm cov insulins rau Lantus® SoloStar®, nws yuav tsum tau kho cov tshuaj txhua hnub ntawm cov tshuaj insalin los yog hloov cov tshuaj tiv thaiv kab mob tsis haum tshuaj (koob tshuaj thiab kev tswj hwm ntawm luv luv ua yeeb yam insulins lossis lawv cov analogues, nrog rau cov tshuaj ntawm qhov ncauj hypoglycemic).

Thaum hloov cov neeg mob los ntawm ob-lub sijhawm tswj hwm cov tshuaj insulin-isofan rau ib qho kev tswj hwm ntawm Lantus® SoloStar®, cov tshuaj txhua hnub ntawm cov tshuaj insal hauv ib hnub yuav tsum tau txo 20-30% hauv thawj lub limtiam ntawm kev kho mob kom txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab sawv ntxov. Nyob rau lub sijhawm no, qhov kev txo qis ntawm Lantus yuav tsum tau them nyiaj los ntawm kev nce ntxiv ntawm cov tshuaj insulin luv luv, tom qab ntawd los ntawm kev kho tus kheej rau cov koob tshuaj.

Ib yam li lwm yam tshuaj tiv thaiv kab mob rau tib neeg, cov neeg mob tau txais kev siv tshuaj ntau heev vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin tuaj yeem ntsib kev nce ntxiv rau cov lus teb rau insulin thaum hloov mus rau Lantus® SoloStar®. Hauv kev hloov pauv mus rau Lantus® SoloStar® thiab hauv thawj lub lis piam tom qab nws, yuav tsum ua tib zoo saib xyuas ntshav qabzib thiab yuav tsum tau ua, yog tias tsim nyog, kev kho ntawm insulin dosing regimen.

Cov tshuaj yuav tsum tsis txhob muab tshuaj rau qhov leeg. Hauv / hauv kev qhia ntawm cov tshuaj ib txwm muaj rau kev tswj hwm ntawm subcutaneous, tuaj yeem ua rau kev txhim kho ntawm cov ntshav khov qis.

Lantus® SoloStar® yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulin los yog ua kom sib xyaw. Nco ntsoov tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj. Thaum muab sib xyaw los yog zom, qhov profile ntawm insulin glargine yuav hloov lub sijhawm. Kev sib xyaw nrog lwm cov insulins tuaj yeem ua rau dej nag.

Lub sijhawm tiv thaiv ntawm cov tshuaj Lantus® SoloStar® nyob ntawm kev ua kom thaj tsam ntawm thaj chaw ntawm nws lub chaw tswj hwm sc.

Cov kev cai rau siv thiab tuav ntawm cov ntawv ua ntej ua tiav cov kua txob SoloStar®

Ua ntej siv thawj zaug, rab koob xaum xaum yuav tsum khaws cia ntawm chav tsev li 1-2 teev.

Lub cev tsis siv SoloStar ® cov koob txhaj tshuaj yuav tsum tsis tau siv thiab muab pov tseg.

Txhawm rau tiv thaiv kev kis mob, tus cwj mem uas muaj menyuam qhwv ua ntej tsuas yog siv los ntawm ib tus neeg mob thiab yuav tsum tsis txhob hloov mus rau lwm tus.

Ua ntej siv SoloStar® Syringe Cwj mem, ua tib zoo nyeem cov lus qhia siv.

Ua ntej siv txhua qhov, ua tib zoo txuas lub koob tshiab rau daim duab xaum xaum thiab kev sim kev nyab xeeb. Tsuas siv cov koob uas txuam nrog SoloStar ® yuav tsum siv.

Cov kev tiv thaiv tshwj xeeb yuav tsum tau ceev faj kom tsis txhob muaj kev sib tsoo nrog kev siv koob thiab qhov kis tau ntawm kev kis tus kab mob.

Txawm li cas los xij koj yuav tsum siv SoloStar® koob txhaj tshuaj yog tias nws puas ntsoog lossis yog koj tsis paub tseeb tias nws yuav ua haujlwm tau zoo.

Txhua lub sijhawm muaj SoloStar® koob txhaj tshuaj nyob hauv tes yog tias koj poob lossis puas ib daim ntawv ntawm SoloStar® koob txhaj tshuaj.

Yog tias SoloStar® koob txhaj tshuaj yuav tsum tau muab cia rau hauv tub yees, nws yuav tsum tau ua tawm 1-2 teev ua ntej qhov kev npaj txhaj tshuaj kom daws tau qhov chaw sov. Kev tswj hwm cov tshuaj chine chilled yog qhov mob ntau dua. Kev siv SoloStar® Syringe Pen yuav tsum tau muab rhuav pov tseg.

SoloStar® koob txhaj tshuaj yuav tsum tiv thaiv cov plua tshauv thiab av. Sab nraud ntawm SoloStar® Syringe Pen tuaj yeem ntxuav los ntawm kev so nws nrog daim ntaub noo. Tsis txhob pleev dej rau hauv dej, yaug thiab roj SoloStar® koob txhaj tshuaj, vim qhov no tuaj yeem ua rau nws puas.

SoloStar ® Syringe Pen siv cov tshuaj insulin kom raug thiab nyab xeeb siv. Nws tseem yuav tsum tau ua tib zoo saib xyuas. Zam zam cov xwm txheej uas ua rau SoloStar ® koob txhaj tshuaj yuav tshwm sim. Yog tias koj xav hais tias kev puas tsuaj rau ib qho piv txwv ntawm SoloStar® koob txhaj tshuaj, siv tus cwj mem tshiab.

Theem 1. Tshuaj Insulin

Koj yuav tsum kos daim ntawv lo rau ntawm SoloStar® Syringe Cwj mem kom paub tseeb tias nws muaj cov insulin tseeb. Rau Lantus, SoloStar® koob txhaj tshuaj yog grey nrog lub khawm xiav rau txhaj. Tom qab hle lub hau ntawm rab koob txhaj tshuaj, cov tsos ntawm cov tshuaj insulin nyob hauv nws yog tswj: cov tshuaj insulin yuav tsum muaj pob tshab, tsis muaj xim, tsis muaj cov khoom ua kom pom thiab zoo li dej nyob hauv xwm yeem.

Theem 2. Txuas rab koob

Tsuas yog siv cov koob uas txuam nrog SoloStar® koob txhaj tshuaj xwb yuav tsum tau siv. Txog kev txhaj txhua zaus, yuav tsum siv rab koob tshiab tshiab uas tsis huv. Tom qab hle lub hau tawm, rab koob yuav tsum tau muab ntsia kom zoo ntawm daim duab syringe.

Theem 3. Ua qhov ntsuas kev nyab xeeb

Ua ntej txhua txoj kev txhaj tshuaj, nws yog qhov yuav tsum tau ua qhov kev ntsuas kev nyab xeeb thiab ua kom cov koob txhaj tshuaj ua haujlwm zoo thiab cua tshuab tau tshem tawm.

Ntsuas ib koob tshuaj sib npaug rau 2 ntsuas.

Cov kaus mom uas siv sab nraud thiab sab hauv yuav tsum tau muab tshem tawm.

Muab tus cwj mem ntim nrog rab koob tso tawm, maj mam coj mus rhaub cov insulin lub taub hau nrog koj tus ntiv tes kom txhua npuas pa mus rau rab koob.

Tag nrho nias lub pob txhaj.

Yog tias muaj cov tshuaj insulin rau ntawm qhov kawg ntawm rab koob, qhov no txhais tau tias rab koob xaum thiab rab koob ua hauj lwm zoo.

Yog tias cov tshuaj insulin tsis tshwm sim rau ntawm lub ntsis ntawm rab koob, tom qab ntawd cov kauj ruam 3 tuaj yeem rov ua dua kom txog thaum insulin tshwm ntawm lub taub ntawm rab koob.

Theem 4. Xaiv Xaiv

Lub khob ntim tshuaj yuav tsum qhia "0" tom qab kev ntsuas kev nyab xeeb tiav. Tom qab ntawd, cov koob tshuaj tsim nyog tau tsim muaj.

Theem 5. Ceeb Toom

Tus neeg mob yuav tsum tau qhia rau cov txheej txheem txhaj tshuaj los ntawm tus kws kho mob paub.

Lub koob yuav tsum tau muab tso rau hauv qab daim tawv nqaij.

Theem 6. Tshem thiab tshem tawm ntawm rab koob

Tom qab tshem rab koob, kaw SoloStar® koob txhaj tshuaj nrog lub hau.

Analogs hauv kev muaj pes tsawg leeg thiab qhia txog kev siv

Npe	Nqe hauv Lavxias	Nqe hauv Ukraine
Lantus SoloStar cov tshuaj insulin glargine	45 rub	250 UAH
Tujeo SoloStar cov tshuaj insulin glargine	30 RUB	--
Levemir Penfill cov tshuaj insulin	167 tshiav	--

Cov npe saum toj no ntawm cov yeeb tshuaj analogues, uas qhia Lantus hloov chaw, yog qhov tsim nyog tshaj plaws vim tias lawv muaj tib cov tshuaj sib luag thiab sib luag ua ke raws li kev taw qhia rau kev siv

Sib txawv muaj pes tsawg leeg, tuaj yeem ua ke nyob rau hauv kev taw qhia thiab cov qauv ntawm daim ntawv thov

Npe	Nqe hauv Lavxias	Nqe hauv Ukraine
Cov tshuaj insulin	178 RUB	133 UAH
Actrapid	35 txhuam	115 UAH
Actrapid nm	35 txhuam	115 UAH
Actrapid nm mem tes	469 rub	115 UAH
Biosulin P	175 rub	--
Insuman Ceev Heev Tib Neeg Insulin	1082 txhuam	100 UAH
Humodar p100r tib neeg cov insulin	--	--
Tib neeg cov insulin tsis tu ncua	28 RUB	1133 UAH
Yawg Hlob	--	79 UAH
Gensulin P tib neeg cov tshuaj insulin	--	104 UAH
Insugen-R (Tsis tu ncua) tib neeg cov kua dej	--	--
Rinsulin P tib neeg cov tshuaj insulin	433 plhaw	--
Farmasulin N tib neeg cov tshuaj insulin	--	88 UAH
Tshuaj insulin Cov tib neeg cov tshuaj insulin	--	593 UAH
Monodar insulin (nqaij npuas)	--	80 UAH
Kev ntsuas cov tshuaj insulin lispro	57 rub	221 UAH
Lispro insulin recombinant Lispro	--	--
NovoRapid Flexpen Cwj mem Insulin Aspart	28 RUB	249 UAH
NovoRapid Penfill tshuaj insulin aspart	1601 rub	1643 UAH
Epidera Insulin Glulisin	--	146 UAH
Apidra SoloStar Glulisin	449 RUB	2250 UAH
Biosulin N	200 txhuam	--
Insuman basal tib neeg insulin	1170 RUB	100 UAH
Protafan	26 RUB	116 UAH
Humodar b100r tib neeg cov insulin	--	--
Humulin nph tib neeg insulin	166 RUB	205 UAH
Gensulin N tib neeg cov insulin	--	123 UAH
Insugen-N (NPH) tib neeg cov tshuaj insulin	--	--
Protafan NM neeg insulin	356 rub	116 UAH
Protafan NM Penfill insulin tib neeg	857 rub	590 UAH
Rinsulin NPH tib neeg cov tshuaj insulin	372 RUB	--
Farmasulin N NP tib neeg cov kua dej	--	88 UAH
Cov Tshuaj Insulin Stabiliser Cov Tib Neeg Ua Reinbinant Insulin	--	692 UAH
Insulin-B Berlin-Chemie Insulin	--	--
Monodar B insulin (nqaij npuas)	--	80 UAH
Humodar k25 100r tib neeg cov insulin	--	--
Gensulin M30 tib neeg cov insulin	--	123 UAH
Insugen-30/70 (Bifazik) insulin tib neeg	--	--
Insuman Comb insulin tib neeg	--	119 UAH
Mikstard tib neeg cov kua dej	--	116 UAH
Mixtard Penfill Insulin Tib Neeg	--	--
Farmasulin N 30/70 tib neeg cov tshuaj insulin	--	101 UAH
Tib neeg cov insulin Mulin	212 RUB	--
Cov Pwm Ua Sib xyaw ua kua insulin lispro	57 rub	221 UAH
Novomax Flekspen insulin aspart	--	--
Ryzodeg Flextach insulin aspart, insulin degludec	6 699 tshiav	2 UAH

Yuav ua li cas thiaj nrhiav tau qhov pheej yig tshuaj ntawm cov tshuaj kim?

Txhawm rau kom pom qhov pheej yig cov khoom sib piv rau cov tshuaj, cov dav dav lossis cov lus sau, ua ntej txhua yam peb pom zoo kom them sai sai rau qhov muaj pes tsawg leeg, uas yog rau tib cov tshuaj nquag thiab qhia tau rau kev siv. Cov tshuaj sib xyaw zoo ib yam ntawm cov tshuaj yuav qhia tau tias cov tshuaj cuam tshuam nrog cov tshuaj, kws tshuaj sib npaug lossis chaw muag tshuaj. Txawm li cas los xij, tsis txhob hnov qab txog qhov ua tsis muaj zog ntawm cov tshuaj uas zoo sib xws, uas tuaj yeem cuam tshuam kev nyab xeeb thiab ua haujlwm. Tsis txhob hnov qab txog cov lus qhia ntawm cov kws kho mob, kev noj tshuaj rau nws tus kheej tuaj yeem tsim kev puas tsuaj rau koj kev noj qab haus huv, yog li nco ntsoov sab laj nrog koj tus kws kho mob ua ntej siv cov tshuaj.

Kev qhia teeb npe

Sawv cev ntawm Sanofi-aventis Pab Pawg Sib Koom Tes Cov Chaw Lag Luam (Fabkis)

subcutaneous tov 100 IU / ml, 3 ml cartridge, Optiklik 5 cartridge system, cardboard pob 1, EAN code: 4030685479170, No. P N014855 / 01, 2006-07-21 los ntawm Aventis Pharma Deutschland GmbH (Lub Teb Chaws Yelemees), Lub Sij Hawm sijhawm kawg rau hnub 2009-01-28

Cov Tshuaj Hauv Tshuaj

Cov tshuaj insulin glargine yog ib qho piv txwv ntawm tib neeg cov tshuaj insulin, tus cwj pwm los ntawm solubility qis hauv qhov nruab nrab tsis zoo. Ua ib feem ntawm qhov npaj Lantus, nws yog soluble kiag li, uas tau ua kom muaj cov acidic ib puag ncig ntawm cov tshuaj txhaj (pH4). Tom qab qhia txog cov roj ntsha subcutaneous, txoj kev daws teeb meem, vim nws cov acidity, nkag mus rau hauv kev cuam tshuam nruab nrab nrog kev tsim cov microprecipitate, los ntawm cov tshuaj insulin glargine tso tawm tas li, muab qhov ua kom pom tseeb, du (tsis muaj peaks) profile ntawm qhov nkhaus-sijhawm nkhaus, nrog rau lub sijhawm ua haujlwm ntev dua.

Kev sib txuas lus nrog insulin receptors: cov lus sib khi rau cov insulin glargine thiab tib neeg cov insulin receptors yog qhov sib ze heev, thiab nws muaj peev xwm los tawm kev lom neeg uas zoo ib yam li insulin endogenous.

Qhov kev txiav txim siab tseem ceeb tshaj plaws ntawm insulin, thiab vim li no insulin glargine, yog kev cai ntawm cov metabolism hauv cov piam thaj. Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib los ntawm kev ua kom cov piam thaj los ntawm qhov nqaij (tshwj xeeb cov leeg pob txha thiab cov nqaij mos), nrog rau qhov ua kom cov ntshav qabzib nyob hauv lub siab (gluconeogenesis). Cov tshuaj insulin inhibits adipocyte lipolysis thiab proteolysis, thaum ua kom cov protein synthesis zoo.

Lub sijhawm ntev ntawm kev ua ntawm insulin glargine yog ncaj qha ntsig txog qhov txo tus nqi ntawm nws qhov nqus, uas tso cai rau cov tshuaj no siv ib hnub ib zaug. Tom qab kev tswj hwm sc, qhov pib ntawm kev tshwm sim tshwm sim, nyob rau nruab nrab, tom qab 1 teev Lub sijhawm nruab nrab ntawm kev ua yog 24 teev, qhov siab tshaj yog 29 teev.

Cev xeeb tub thiab lactation

Hauv cov kev tshawb fawb tsiaj, tsis muaj cov ntaub ntawv ncaj qha lossis tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine.

Txog tam sim no, tsis muaj txheeb cais hais txog kev siv cov tshuaj thaum cev xeeb tub. Muaj pov thawj ntawm kev siv Lantus hauv 100 tus poj niam cev xeeb tub muaj ntshav qab zib. Cov chav kawm thiab kev tshwm sim ntawm cev xeeb tub hauv cov neeg mob no tsis txawv ntawm cov poj niam cev xeeb tub uas muaj ntshav qab zib uas tau txais lwm yam tshuaj insulin.

Kev teem caij ntawm Lantus hauv cov poj niam cev xeeb tub yuav tsum tau ua nrog ceev faj. Rau cov neeg mob uas muaj kab mob ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj kev cai tsim nyog ntawm cov khoom noj hauv lub cev thoob plaws lub cev xeeb tub. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntxiv thaum lub sijhawm thib ob thiab thib peb. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Hauv cov pojniam muaj menyuam, kev txhaj tshuaj thiab noj zaub mov kom haum.

Sab sij huam

Kev ntshav siab - qhov tshwm sim uas tsis xav tau tshaj plaws ntawm kev kho mob insulin tuaj yeem tshwm sim yog tias cov koob tshuaj insulin ntau dhau los piv rau qhov xav tau. Kev tawm tsam ntawm kev mob ntshav qab zib siab heev, tshwj xeeb yog kev rov ua dua, tuaj yeem ua rau kev puas tsuaj rau cov hlab ntshav ntawm lub paj hlwb. Kev mob ntshav qog ntshav ntev thiab mob ntshav qab zib tsawg tuaj yeem tsim kev puas tsuaj rau cov neeg mob lub neej. Cov tsos mob ntawm adrenergic txee-kev tswj hwm (ua kom lub cev sympathoadrenal ua teb rau cov ntshav qab zib) feem ntau ua ntej cov leeg mob neuropsychiatric mob vim muaj ntshav qab zib tsawg (nco qab los yog nws ploj, ua kom mob huam): kev tshaib kev nqhis, ua tsis taus pa, hws txias, tachycardia (sai ntawm kev txhim kho hypoglycemia thiab tsawg dua nws yog qhov tseem ceeb, qhov tseeb tshaj tawm cov tsos mob ntawm adrenergic counterregulation).

Cov xwm txheej tsis zoo ntawm lub qhov muag. Cov kev hloov pauv tseem ceeb hauv cov kev cai ntawm cov piam thaj hauv cov ntshav tuaj yeem ua rau tsis pom kev ib ntus vim yog qhov hloov ntawm cov nqaij mos thiab qhov ntsuas qhov ntsuas ntawm lub lens ntawm lub qhov muag. Lub sijhawm ntev ua haujlwm ntawm cov ntshav qabzib txo cov kev pheej hmoo ntawm kev kho mob ntawm cov ntshav qab zib retinopathy. Insulin kho, nrog cov kev hloov pauv hauv cov ntshav qabzib, tuaj yeem ua rau muaj kev phom sij dua ib ntus dhau ntawm qhov mob ntshav qab zib. Hauv cov neeg mob uas muaj kev tu ncua sai, tshwj xeeb tshaj yog cov uas tsis tau txais kev kho mob photocoagulation, kev mob ntshav qab zib ntau tuaj yeem ua rau txoj kev txhim kho tsis pom kev hauv lub cev.

Lipodystrophy. Ib yam li lwm yam tshuaj insulin, lipodystrophy thiab ncua hauv zos hauv kev nqus / nqus ntawm insulin tuaj yeem txhim kho ntawm thaj chaw txhaj tshuaj.Hauv kev soj ntsuam hauv chaw kho mob thaum lub sij hawm kho insulin nrog Lantus, lipodystrophy tau pom nyob rau hauv 1-2% ntawm cov neeg mob, thaum lipoatrophy feem ntau tsis xav pom. Kev hloov pauv tsis tu ncua ntawm cov chaw txhaj tshuaj hauv thaj chaw thaj tsam uas tau pom zoo rau kev tswj fwm ntawm cov tshuaj insulin tuaj yeem pab txo qis qhov hnyav ntawm cov tshuaj tiv thaiv no lossis tiv thaiv nws qhov kev txhim kho.

Cov kev tawm tsam hauv cheeb tsam hauv thaj tsam ntawm kev tswj hwm thiab kev fab tshuaj. Thaum kuaj mob thaum siv tshuaj tua kab mob siv Lantus, qhov tshuaj tiv thaiv nyob rau ntawm qhov chaw txhaj tshuaj tau pom nyob hauv 3-4% ntawm cov neeg mob. Xws li suav cov xim liab, mob, khaus, ua xua, o, lossis o. Feem ntau cov kev tshwm sim me me nyob ntawm thaj chaw ntawm cov tshuaj insulin feem ntau daws nyob rau ib ntus ntawm ob peb hnub mus rau ntau lub lis piam. Kev ua xua ntawm cov yam ua kom mob sai rau cov tshuaj insulin yog qhov tsawg. Cov kev xav zoo rau cov tshuaj insulin (suav nrog insulin glargine) lossis cov neeg excipients tuaj yeem ua raws li cov tawv nqaij sawv cev dav dav, angioedema, bronchospasm, arterial hypotension lossis poob siab, thiab yog li yuav tsim kev hem thawj rau tus neeg mob lub neej.

Lwm yam tshuaj tiv thaiv. Kev siv cov insulin tuaj yeem ua rau tsim cov tshuaj tiv thaiv rau nws. Thaum kuaj mob hauv cov pab pawg ntawm cov neeg mob kho nrog insulin-isofan thiab insulin glargine, kev tsim cov tshuaj tiv thaiv kev tiv thaiv nrog tib neeg cov tshuaj insulin tau pom nrog tib zaus. Tsawg tsawg zaus, qhov kuaj pom cov tshuaj tiv thaiv kab mob rau insulin tuaj yeem xav tau qhov kev kho ntau npaum li cas los txhawm rau tshem tawm qhov nyiam los txhim kho hypo- lossis hyperglycemia. Tsis tshua muaj, insulin tuaj yeem ua rau kev ncua ntawm kev ncua ntawm sodium thiab kev tsim ntawm edema, tshwj xeeb tshaj yog yog tias muaj zog los kho cov tshuaj insulin ua rau muaj kev txhim kho yav dhau los tsis muaj txiaj ntsig ntawm kev ua tiav ntawm cov txheej txheem metabolic.

Kev sib txuam

Ib tug xov tooj ntawm cov tshuaj cuam tshuam rau cov metabolism hauv cov piam thaj, uas yuav xav tau kev kho kom haum rau cov tshuaj insulin glargine.

Kev npaj uas tuaj yeem txhim kho hypoglycemic ua haujlwm ntawm cov tshuaj insulin thiab nce lub ntsiab lus rau kev txhim kho hypoglycemia suav nrog cov tshuaj hypoglycemic hauv qhov ncauj, ACE inhibitors, disopyramides, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates thiab sulfonamide antimicrobials. Cov tshuaj uas tuaj yeem txo cov nyhuv hypoglycemic ntawm insulin suav nrog cov tshuaj corticosteroids, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, gestagens, phenothiazine derivatives, somatotropin, sympathomimetics xws li epinephrine (adrenaline), salbutamolum, terbutoidin thiab cov tshuaj hormones. proteases, qee cov tshuaj tiv thaiv kev ua haujlwm (piv txwv li olanzapine lossis clozapine).

Beta-blockers, clonidine, lithium ntsev thiab dej cawv tuaj yeem txhim kho thiab ua kom cov nyhuv tsis muaj zog tsis txaus ntawm cov kua dej.

Pentamidine tuaj yeem ua rau hypoglycemia, uas qee zaum hloov los ntawm hyperglycemia.

Tsis tas li ntawd, nyob rau hauv kev cuam tshuam ntawm cov tshuaj sympatholytic xws li beta-blockers, clonidine, guanfacine thiab reserpine, cov cim ntawm adrenergic counter-txoj cai yuav raug txo lossis ploj.

Noj ntau dhau

Cov tsos mob Mob ntshav qis thiab qee zaum ua rau muaj ntshav nce siab ntau, hem tus neeg mob lub neej.

Kev Kho Mob: Lub sijhawm mob ntshav qab zib tsawg kawg feem ntau tso tseg los ntawm kev noj zaub mov zom zaub mov kom yooj yim. Nws yog qhov tsim nyog yuav tsum hloov pauv kev noj tshuaj, tshuaj noj lossis ua haujlwm rau lub cev. Kev mob tshwm sim ntawm kev mob ntshav siab tshaj, nrog rau kev tsis nco qab, ua kom mob hlwb lossis mob hlwb, yuav tsum tso ntshav tshuaj lossis ntshav qab zib ntawm glucagon, ntxiv rau kev tswj hwm ntawm cov tshuaj dextrose tov. Lub sijhawm ntev kom tau cov carbohydrate thiab kev saib xyuas tshwj xeeb yuav tsum tau ua, raws li Kev mob ntshav qog ntshav qab zib tuaj yeem rov tshwm sim tom qab pom kev txhim kho hauv chaw kho mob.

Cov lus qhia tshwj xeeb

Lantus tsis yog cov tshuaj ntawm kev xaiv rau kev kho mob ntshav qab zib ketoacidosis. Hauv cov xwm txheej zoo li no, iv kev tswj hwm ntawm kev ua yeeb yam luv luv yog kev pom zoo. Vim tias kev ua haujlwm nrog Lantus tsawg tsawg, nws tsis tuaj yeem txheeb xyuas nws qhov ua tau zoo thiab kev nyab xeeb hauv kev kho cov neeg mob uas lub siab tsis ua haujlwm lossis cov neeg mob uas muaj mob me lossis mob raum tsis ua haujlwm. Hauv cov neeg mob uas lub raum khiav tsis zoo, qhov xav tau cov tshuaj insulin tuaj yeem txo qis vim qhov ua kom tsis muaj zog ntawm nws cov txheej txheem tshem tawm. Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum ua haujlwm tuaj yeem ua rau cov insulin txuas ntxiv kom tsawg. Hauv cov neeg mob uas muaj kev tiv thaiv kabmob hepatic txaus, qhov kev xav tau rau insulin tuaj yeem raug txo vim muaj kev txo qis hauv kev muaj peev xwm gluconeogenesis thiab biotransformation ntawm insulin. Kev tswj hwm qhov tsis muaj txiaj ntsig nyob rau qib ntawm cov piam thaj hauv cov ntshav, nrog rau yog tias muaj tus cwj pwm ntawm kev txhim kho hypo- lossis hyperglycemia, ua ntej kev taug ua ntawm kev kho cov tshuaj ntau, nws yog qhov yuav tsum tau kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem kev kho mob, qhov chaw ntawm kev tswj hwm tshuaj thiab cov txheej txheem ntawm kev tsim nyog sc txhaj tshuaj, xav txog txhua yam cuam tshuam rau cov teeb meem.

Kev ntshav siab. Lub sijhawm ntawm kev txhim kho hypoglycemia yog nyob ntawm qhov profile ntawm kev ua ntawm kev siv tshuaj insulin thiab yuav, yog li ntawd, hloov nrog qhov hloov pauv ntawm kev kho mob. Vim tias qhov nce ntxiv hauv lub sijhawm nws yuav siv sijhawm ntev rau insulin tuaj rau hauv lub cev thaum siv Lantus, qhov ntxim nyiam ntawm kev txhim kho nocturnal hypoglycemia tsawg zuj zus, thaum sawv ntxov tej zaum yuav muaj ntau ntxiv. Cov neeg mob uas cov neeg mob ntshav qab zib tsawg yuav muaj tej yam tseem ceeb hauv kev kho mob, xws li cov neeg mob uas mob hlab ntsha hauv cov hlab ntshav lossis cov hlab ntsha hlwb tsis zoo (muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb ntawm hypoglycemia), nrog rau cov neeg mob uas muaj hlwb ntau dua, tshwj xeeb yog tias lawv tsis tau txais kev kho mob nrog photocoagulation (muaj kev pheej hmoo transient poob ntawm lub zeem muag vim yog txo ntshav qab zib), yuav tsum muaj kev tshwj xeeb yuav tsum tau saib xyuas, thiab nws kuj tseem pom zoo kom mob siab saib xyuas cov ntshav qabzib. Cov neeg mob yuav tsum paub txog cov xwm txheej uas ua ntej ntawm cov qog ntshav qab zib yuav hloov, ua tus neeg hais tsis tshua pom zoo lossis tsis tuaj koom nrog qee pab pawg muaj kev pheej hmoo. Cov pab pawg no suav nrog:

- cov neeg mob uas tau txhim kho txoj cai ntawm cov ntshav piam thaj,

- cov neeg mob uas tus mob ntshav qab zib tsawg zuj zus,

- Cov neeg laus laus,

- cov neeg mob neuropathy,

- cov neeg mob mob ntshav qab zib,

- cov neeg mob ntsib mob hlwb,

- cov neeg mob tau txais kev kho mob concomitant nrog lwm cov tshuaj (saib "Kev sib cuam tshuam").

Thaum muaj xwm txheej lossis qis dua glycosylated hemoglobin qib raug sau tseg, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus lej muaj peev xwm tsim rov tshwm sim tsis paub lub sijhawm ntawm hypoglycemia (tshwj xeeb tshaj yog thaum tsaus ntuj).

Cov neeg mob ua raws li lub caij teem tseg, kev noj haus thiab kev noj haus, kev siv tshuaj insulin kom zoo thiab tswj kev pib ntawm cov tsos mob ntawm tus mob ntshav qab zib tsawg ua rau muaj kev txo qis hauv kev pheej hmoo ntawm lub qog ntshav qab zib. Qhov tseeb uas ua rau kom qhov mob ntshav siab tsis txaus txog qhov yuav tsum tau saib xyuas tshwj xeeb, raws li tej zaum yuav siv tshuaj kho cov tshuaj insulin. Tej yam no suav nrog:

- kev hloov chaw ntawm cov thawj coj ntawm insulin,

- kev rhiab ntxiv rau insulin (piv txwv li, thaum tshem tawm cov kev ntxhov siab),

- txawv txav, nce lossis lub sijhawm ua haujlwm lub cev ntev,

- cov kab mob sib xyaw nrog ntuav, zawv plab,

- ua txhaum kev noj haus thiab kev noj haus,

- skipped noj mov

- qee qhov tsis cuam tshuam ntawm cov tshuaj endocrine (piv txwv li hypothyroidism, tsis muaj txiaj ntsig ntawm adenohypophysis lossis adrenal cortex),

- concomitant kev kho mob nrog rau lwm yam tshuaj.

Cov kab mob sib kis. Hauv cov kab mob sib cuam tshuam, yuav tsum muaj kev saib xyuas ntshav qabzib ntau dua. Feem ntau, kev txheeb xyuas yog ua rau muaj cov ketone lub cev nyob hauv cov zis, thiab kev kho ntawm cov tshuaj ntau npaum li cas ntawm cov tshuaj insulin kuj tseem xav tau. Qhov kev xav tau rau insulin feem ntau nce. Cov neeg mob ntshav qab zib hom 1 yuav tsum txuas ntxiv kev haus tsawg kawg yog ib qho me me ntawm carbohydrates, txawm tias lawv tsuas tuaj yeem haus tau me me ntawm cov zaub mov lossis tsis tuaj yeem noj tsis txhua, yog tias lawv ntuav, thiab lwm yam. Cov neeg mob no yuav tsum tsis txhob tso tseg txoj kev siv tshuaj insulin.

Cev xeeb tub thiab lactation

Cov ntaub ntawv kho mob hais txog kev siv tshuaj insulin glargine rau cov poj niam cev xeeb tub, tau txais thaum tswj kev soj ntsuam, tsis tuaj. Txwv tsawg
cev xeeb tub, nrog rau lub xeev ntawm kev noj qab haus huv ntawm lub cev xeeb tub thiab cov menyuam tshiab. Tam sim no tsis muaj lwm cov ntaub ntawv tseem ceeb txog kabmob sib kis.

Hauv cov kev tshawb fawb tsiaj, tsis muaj cov ntaub ntawv ncaj qha lossis tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine. Kev siv ntawm Lantus thaum cev xeeb tub tuaj yeem txiav txim siab yog tias tsim nyog.

Rau cov neeg mob uas muaj ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj kev tswj hwm kev mob ntshav qab zib thoob plaws hauv lub cev xeeb tub. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab, feem ntau, nce ntxiv thaum txiav thib ob thiab peb feem plaub. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Kuj tsis paub meej tias insulin glargine kis mus rau niam mis tau licas. Tsis muaj teebmeem hauv metabolic thaum noj insulin glargine hauv tus menyuam mos tsis tau xav txog, txij li, yog cov protein, insulin glargine tau tawg rau hauv cov amino acids hauv tib neeg lub plab zom mov.

Hauv kev ua poj niam mis, nws yuav tsim nyog kho qhov tshuaj ntau npaum li cas ntawm cov tshuaj insulin thiab kev noj haus.

Lantus thiab Tujeo: qhov sib txawv thiab zoo sib xws

Ib qho ntawm cov qauv tseem ceeb thaum xaiv tib neeg cov tshuaj insulin yog qhov muaj feem cuam tshuam txog qhov nrawm ntawm nws cov nyhuv ntawm lub cev. Piv txwv, muaj cov uas ua tawm sai heev thiab kev txhaj tshuaj yuav tsum tau ua kom tiav peb caug lossis plaub caug feeb ua ntej noj mov.

Tab sis muaj cov neeg uas, ntawm qhov tsis sib xws, muaj qhov cuam tshuam ntev heev, lub sijhawm no tuaj yeem mus txog kaum ob teev. Nyob rau hauv rooj plaub tom kawg, hom kev ua no tuaj yeem ua rau kev txhim kho ntshav qab zib hauv ntshav qab zib mellitus.

Yuav luag txhua tus neeg niaj hnub insulin analogues sai sai. Qhov nrov tshaj plaws yog haiv neeg insulin, nws ua nyob rau hauv plaub lossis tsib feeb tom qab txhaj tshuaj.

Hauv qhov dav dav, nws yog qhov yuav tsum tau hais txog qhov zoo hauv qab no ntawm cov analogues niaj hnub:

Nruab nrab cov ntsiab lus.
Cov tshuaj tau los ntawm kev siv cov thev naus laus zis DNA thev naus laus zis niaj hnub.
Qhov tshiab cov tshuaj insulin niaj hnub muaj cov khoom tshiab pharmacological.

Ua tsaug rau txhua yam ntawm cov khoom tau hais los saum toj no, nws muaj peev xwm ua kom tiav qhov sib txig sib luag ntawm kev pheej hmoo ntawm kev tsim dheev hauv cov suab thaj thiab tau txais cov phiaj glycemic.

Ntawm cov tshuaj muaj npe zoo niaj hnub tuaj yeem txheeb tau:

Qhov ntsuas ntawm ultrashort insulin, uas yog Apidra, Humalog, Novorapid.
Lub sijhawm ntev - Levemir, Lantus.

Yog tias tus neeg mob tau muaj qhov tsis zoo tom qab siv tshuaj, tus kws kho mob pom zoo kom hloov cov tshuaj insulin.

Tab sis koj yuav tsum tau ua qhov no tsuas yog nyob ntawm kev saib xyuas ntawm tus kws tshaj lij thiab soj ntsuam tus neeg mob kom zoo thaum lub sijhawm hloov tus txheej txheem.

Dab tsi yog nws qhov sib txawv ntawm Lantus, uas tau paub dav thiab tshaj tawm ua ntej? Ib yam li Lantus, cov tshuaj tshiab muaj nyob rau hauv cov raj tshuaj leeg tau yooj yim.

Txhua lub raj muaj ib koob tshuaj, thiab rau nws siv nws yog qhov txaus los qhib thiab tshem lub hau thiab nyem qhov poob ntawm cov ntsiab lus los ntawm koob tsim. Kev rov qab siv lub nqus dej ntawm lub raj tuaj yeem ua tau tsuas yog ua ntej nws raug tshem tawm los ntawm lub koob txhaj tshuaj.

Ib yam li hauv Lantus npaj, hauv Tujeo cov tshuaj nquag yog glargine - ib qho khoom sib txig ntawm cov kua dej tsim hauv tib neeg lub cev. Cov syntarized glargine yog tsim los ntawm txoj kev ntawm DNA rov ua kom muaj kev txawv txav ntawm Escherichia coli.

Qhov ua rau lub ntsej muag tsis zoo yog yam ua kom pom kev tsis sib xws thiab lub sijhawm ua haujlwm ntev, uas yog ua tiav vim yog cov haujlwm ntawm cov kev coj ua ntawm tib neeg lub cev. Cov tshuaj ua kom nquag ntawm cov tshuaj yog qhia rau hauv tib neeg cov roj ntsha ua haujlwm, hauv qab daim tawv nqaij.

Ua tsaug rau qhov no, kev txhaj tshuaj yog yuav luag tsis muaj kev mob siab thiab yooj yim heev rau kev ua.

Cov tshuaj acidic yog neutralized, uas ua rau kev tsim ntawm micro-reagents muaj peev xwm maj mam tso tawm cov tshuaj nquag.

Raws li qhov tshwm sim, insulin concentration nce siab tus, yam tsis muaj peaks thiab ntse dauv, thiab ntev rau ntev. Qhov pib ntawm kev ua yog pom 1 teev tom qab txhaj ntawm subcutaneous rog. Qhov kev txiav txim kav mus txog tsawg kawg 24 teev txij li lub sijhawm tswj hwm.

Hauv qee kis, muaj kev txuas ntxiv ntawm Tujeo rau 29 - 30 teev. Nyob rau tib lub sijhawm, qhov txo qis hauv qabzib yog tiav tom qab 3-4 koob, uas yog, tsis pub dhau peb hnub tom qab pib siv tshuaj.

Ib yam li Lantus, ib feem ntawm cov tshuaj insulin tau tawg txawm tias ua ntej nws nkag rau hauv cov ntshav, hauv cov roj ntsha, nyob hauv qab ntawm cov kua qaub nyob rau ntawd. Yog li ntawd, thaum lub sijhawm tshuaj ntsuam, cov ntaub ntawv tuaj yeem tau txais ntawm qhov muaj zog ntxiv ntawm cov tshuaj insulin cov khoom hauv cov ntshav.

Lub ntsiab sib txawv los ntawm Lantus yog qhov sib xyaw ntawm cov hluavtaws insulin hauv ib zaug xwb ntawm Tujeo. Hauv kev npaj tshiab, nws yog peb zaug ntau dua thiab cov nqi rau 300 IU / ml. Vim tias qhov no, txo qis qhov tseem ceeb ntawm txhua hnub ntawm kev txhaj tshuaj tau tiav.

Tsis tas li ntawd, raws li Sanofi, kev nce ntxiv rau hauv cov tshuaj muaj qhov cuam tshuam rau "kev ncaj ncees" ntawm cov tshuaj.

Vim tias lub sijhawm nce ntxiv ntawm cov kev tswj hwm, ib qho tseem ceeb txo qis ntawm qhov qis tshaj tawm ntawm glargine tso tawm tau tiav.

Thaum siv kom raug, cov ntshav qog ntshav qab zib feem ntau pom tsuas yog thaum hloov los ntawm lwm cov tshuaj insulin-rau hauv Tujeo. 7-10 hnub tom qab pib noj cov tshuaj hypoglycemia dhau los ua qhov tsis tshua muaj tshwm sim thiab atypical tshwm sim thiab tuaj yeem qhia qhov xaiv tsis raug ntawm lub sijhawm sib txawv rau kev siv tshuaj.

Muaj tseeb, qhov kev nce siab peb-zaug hauv kev ua rau cov tshuaj ua kom tsis tshua nyiam. Yog tias Lantus tuaj yeem siv rau cov ntshav qab zib hauv cov menyuam yaus thiab cov hluas, ces kev siv Tujeo raug txwv. Cov neeg tsim khoom lag luam pom zoo kom siv cov tshuaj no tshwj xeeb ntawm lub hnub nyoog 18 xyoo.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj yog npaj rau subcutaneous thawj coj.

Cov tshuaj yuav tsum tsis txhob muab tshuaj rau qhov leeg. Lub sijhawm ua haujlwm ntawm Lantus yog vim nws qhov kev taw qhia rau hauv cov rog subcutaneous. Kev tswj hwm ntawm ib qho subcutaneous koob tshuaj tuaj yeem ua rau mob ntshav qab zib ntshav ntau heev.

Tsis muaj qhov sib txawv hauv cov ntshiab insum lossis cov piam thaj tom qab kev tswj hwm ntawm Lantus mus rau ntawm lub cev subcutaneous rog ntawm lub plab, xub pwg, lossis ncej puab. Hauv tib thaj chaw ntawm kev tswj hwm tshuaj, nws yog qhov tsim nyog yuav tsum hloov chaw txhaj tshuaj txhua zaus.

Lantus muaj cov insulin glargine, uas yog lub cev ntaj ntev ntev ntawm tib neeg cov insulin. Cov tshuaj yuav tsum tau noj 1 zaug ib hnub ib txwm nyob rau tib lub sijhawm.

Cov koob tshuaj ntawm Lantus thiab lub sijhawm ntawm hnub rau nws cov kev taw qhia tau xaiv ib tus zuj zus.Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus tuaj yeem siv los ua kev kho mob monotherapy lossis sib xyaw nrog lwm cov tshuaj hypoglycemic.

Cov kev ua ntawm cov tshuaj no yog qhia hauv cov koog (UNITS). Cov koog no tau siv rau Lantus nkaus xwb: qhov no tsis zoo ib yam li cov khoom siv uas siv los nthuav qhia kev ua ub no ntawm lwm cov tshuaj insulin (saib Pharmacodynamics).

Cov Neeg Laus (tshaj 65 xyoo)

Hauv cov neeg laus neeg mob, lub raum tsis ua haujlwm tuaj yeem ua rau txo qis qis ntawm cov tshuaj insulin.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Hauv cov neeg mob uas lub raum khiav tsis zoo, qhov xav tau cov tshuaj insulin tuaj yeem txo vim yog txo qis hauv cov tshuaj insulin metabolism.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Hauv cov neeg mob uas muaj lub siab ua haujlwm tsis txaus, xav tau cov tshuaj insulin tuaj yeem txo qis vim qhov txo qis hauv lub peev xwm gluconeogenesis thiab insulin metabolism.

Kev nyab xeeb thiab ua tau zoo ntawm Lantus® tau tsim rau cov neeg hluas thiab menyuam yaus hnub nyoog ntau dua 2 xyoos. Kev tshawb fawb ntawm cov me nyuam yaus uas hnub nyoog qis dua 2 xyoos tsis tau ua.

Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic mus rau Lantus

Thaum hloov cov tshuaj nruab nrab lossis ntev ntev rau kev kho cov tshuaj insulin nrog cov tshuaj tua kab mob Lantus, nws yuav tsum tau hloov kho cov tshuaj txhua hnub ntawm cov tshuaj insal basal, zoo li nws yuav tsim nyog hloov cov tshuaj concomitant antidiabetic therapy (koob tshuaj thiab kev tswj hwm ntawm kev siv tshuaj insulins luv luv lossis lawv cov tshuaj sib piv lossis koob tshuaj txo cov ntshav qab zib )

Thaum hloov cov neeg mob los ntawm kev tswj hwm NPH-insulin ob zaug thaum nruab hnub rau ib qho kev tswj hwm ntawm Lantus hauv kev txiav txim siab txhawm rau txo cov ntshav qog ntshav siab thaum hmo ntuj thiab sawv ntxov ntxov, qhov kev noj tshuaj txhua hnub ntawm basal insulin yuav tsum txo 20-30% hauv thawj lub lis piam ntawm kev kho mob.

Hauv cov neeg mob uas tau txais koob tshuaj NPH-insulin ntau heev, vim tias muaj cov tshuaj tiv thaiv rau tib neeg insulin thaum hloov mus rau Lantus, muaj kev txhim kho zoo hauv cov lus teb tau.

Thaum lub sijhawm hloov mus thiab hauv thawj lub lis piam tom qab nws, kev saib xyuas kev ntsuas ntshav qabzib yog qhov tsim nyog.

Nyob rau hauv cov ntaub ntawv ntawm kev txhim kho kev tswj ntawm cov metabolism thiab qhov tshwm sim ntau ntxiv hauv rhiab rau insulin, kev kho ntxiv ntawm kev siv tshuaj ntau dua tuaj yeem tsim nyog. Kev hloov kho koob tshuaj kuj tseem xav tau, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, lub sijhawm ntawm hnub rau kev tswj hwm tshuaj, lossis thaum muaj lwm yam tshwm sim uas ua rau muaj qhov cuam tshuam ntau ntxiv rau kev txhim kho hypo- lossis hyperglycemia (saib cov lus qhia tshwj xeeb thiab kev ceev faj txog kev siv).

Cov tshuaj no yuav tsum tsis txhob xyaw nrog lwm cov tshuaj insulin los yog diluted. Thaum muab sib xyaw los yog zom, qhov profile ntawm nws qhov kev txiav txim siab yuav hloov zuj zus, ntxiv rau, kev sib xyaw nrog lwm cov insulins tuaj yeem ua rau nag lossis daus.

Ua ntej siv SoloStar® koob txhaj tshuaj, koj yuav tsum ua tib zoo nyeem cov lus qhia rau nws siv.

Thaum yuav siv cov tshuaj

Ib cov tshuaj yog siv rau cov ntshav qab zib, uas yuav tsum tau kho nrog insulin. Ntau zaus nws yog ntshav qab zib hom 1. Qhov tshuaj hormone no tuaj yeem kho rau txhua tus neeg mob uas muaj hnub nyoog 6 xyoo.

Kev siv tshuaj insulin ntev ntev yog qhov tsim nyog los tswj lub cev ceev ceev hauv cov ntshav cov neeg mob cov ntshav. Tus neeg noj qab haus huv hauv cov hlab ntshav yeej ib txwm muaj qee qhov ntawm no, xws li cov ntsiab lus hauv cov ntshav yog hu ua theem pib.

Hauv cov neeg mob uas muaj ntshav qab zib mellitus nyob rau hauv rooj plaub ntawm pancreatic kawg, xav tau cov tshuaj insulin, uas yuav tsum tau txhaj tshuaj tsis tu ncua.

Lwm qhov kev xaiv rau kev tso tawm cov tshuaj hormone hauv ntshav tau hu ua bolus. Nws cuam tshuam nrog kev noj mov - hauv kev teb rau kev nce siab hauv cov ntshav qab zib, qee qhov ntshav ntawm insulin raug tso tawm kom sai glycemia li qub.

Hauv cov ntshav qab zib mellitus, insulins luv luv tau siv rau qhov no.Hauv qhov no, tus neeg mob yuav tsum txhaj nws tus kheej nrog rab koob txhaj tshuaj txhua lub sijhawm tom qab noj mov, nws muaj cov khoom tsim nyog ntawm cov tshuaj hormones.

Hauv cov tsev muag tshuaj, coob tus muab tshuaj sib txawv rau kev kho mob ntshav qab zib tau muag. Yog tias tus neeg mob xav tau siv lub cev ntev ua cov tshuaj hormones, tom qab ntawd dab tsi yog qhov zoo siv - Lantus lossis Levemir? Ntau txoj hauv kev, cov tshuaj no zoo sib xws - ob qho tib si yog qhov pib, yog qhov ua kwv yees thiab ruaj khov nyob rau hauv kev siv.

Peb yuav xyuas seb cov tshuaj hormones no txawv li cas. Nws ntseeg tias Levemir muaj lub neej ua haujlwm ntev dua li Lantus Solostar - txog 6 lub lim tiam tiv thaiv ib hlis. Yog li no, Levemir pom tau tias yooj yim dua rau kis uas koj xav tau nkag rau qhov qis ntawm cov tshuaj, piv txwv li, ua raws li cov zaub mov uas tsis muaj cov carb qis.

Cov kws txawj hais tias Lantus Solostar yuav ua rau muaj kev pheej hmoo mob qog noj ntshav, tab sis tsis muaj ntaub ntawv txaus ntseeg ntawm qhov no tseem.

Qhov txawv ntawm cov tshuaj yog dab tsi?

Qee cov tshuaj tuaj yeem cuam tshuam cov kua nplaum los ntawm insulin, uas yuav xav tau hloov kho rau kev kho mob thiab hloov pauv ntawm Lantus insulin.

Cov kev npaj tshuaj hauv qab no tuaj yeem txhim kho cov nyhuv ntawm insulin glargine:

Tshuaj tiv thaiv qhov ncauj:
tshuaj uas inhibit ACE kev ua si,
Disopyramide - cov tshuaj uas ua rau lub plawv dhia,
Fluoxetine - cov tshuaj siv rau hauv hom mob siab heev,
kev npaj ua rau lub hauv paus ntawm fibroic acid,
tshuaj uas thaiv cov kev ua ntawm monoamine oxidase,
Pentoxifylline - cov tshuaj nyob rau hauv pab pawg ntawm angioprotectors,
Propoxifene yog ib hom tshuaj uas muaj cov tshuaj loog,
salicylates thiab sulfonamides.

Cov tshuaj hauv qab no tuaj yeem ua kom tsis muaj zog ntawm kev ua haujlwm ntawm insulin glargine:

tshuaj los tiv thaiv cov tshuaj hormones uas tiv thaiv kom tsis muaj zog,
Danazol - ib hom tshuaj nyob rau hauv pawg pawg hluavtaws sib piv ntawm androgens,
Diazoxide
tshuaj diuretic
npaj muaj analogues ntawm estrogen thiab progesterone,
npaj tau raws ntawm phenothiazine,
tshuaj uas ua rau kom muaj zog ntawm norepinephrine,
hluavtaws analogues ntawm cov thyroid hormones,
kev npaj muaj lub ntuj lossis khoom cuav ntawm kev loj hlob hormone,
tshuaj tiv thaiv kev puas tsuaj
protease inhibitors.

Kuj tseem muaj qee cov tshuaj uas nws cov teebmeem tshwm sim tsis tau. Lawv tuaj yeem ob leeg ua rau cov nyhuv ntawm insulin glargine thiab txhim kho nws. Cov tshuaj no suav nrog cov hauv qab no:

B-blockers
qee cov ntshav siab txo cov tshuaj
lithium ntsev
cawv

Txawm li cas los xij, tsis txhob hnov qab txog qhov ua tsis muaj zog ntawm cov tshuaj uas zoo sib xws, uas tuaj yeem cuam tshuam kev nyab xeeb thiab ua haujlwm. Tsis txhob hnov qab txog cov lus qhia ntawm cov kws kho mob, kev noj tshuaj rau nws tus kheej tuaj yeem tsim kev puas tsuaj rau koj kev noj qab haus huv, yog li nco ntsoov sab laj nrog koj tus kws kho mob ua ntej siv cov tshuaj.

Peb yuav txheeb xyuas seb yuav siv Lantus li cas - cov lus qhia rau kev siv hais tias nws yuav tsum tau txhaj tshuaj rau hauv cov ntaub so ntswg ntawm lub plab phab ntsa sab xub ntiag, thiab nws tsis tuaj yeem siv tshuaj ntxau. Qhov qauv ntawm cov tshuaj saib xyuas yeeb tshuaj no yuav ua rau txo qis cov ntshav qabzib hauv lub ntsej muag thiab kev txhim kho ntawm lub ntsej muag hypoglycemic.

Ntxiv nrog rau fiber ntau ntawm lub plab, muaj lwm qhov chaw rau qhov kev qhia tau ntawm Lantus - cov pob txha hauv plab, cov leeg nqaij deltoid. Qhov sib txawv hauv cov nyhuv hauv cov xwm txheej no tsis txaus ntseeg lossis tsis tuaj kiag li.

Qhov tshuaj tsis tuaj yeem ua ke ua ke nrog lwm cov tshuaj insulin, nws tsis tuaj yeem xeb ua ntej siv, vim qhov no txo nws cov hauj lwm zoo. Yog tias sib xyaw nrog lwm cov tshuaj pharmacological, dej nag yog tau.

Txhawm rau kom ua tau zoo kho mob, Lantus yuav tsum tau siv txuas ntxiv, txhua txhua hnub nyob rau tib lub sijhawm.

Yuav siv hom tshuaj insulin li cas rau cov ntshav qab zib, kws kho mob endocrinologist yuav qhia koj. Muaj qee kis, kev siv yeeb-tshuaj luv luv tuaj yeem muaj peev xwm kis nrog qee zaum; qee zaum yuav tsum tau muab ob qho tshuaj insulins luv thiab ntev ntev. Ib qho piv txwv ntawm kev sib koom ua ke no yog kev sib koom ua ke ntawm Lantus thiab Apidra, lossis kev sib txuam xws li Lantus thiab Novorapid.

Hauv cov xwm txheej ntawd thaum, rau qee qhov laj thawj, nws yuav tsum hloov cov tshuaj Lantus Solostar hloov mus rau lwm qhov (piv txwv, rau Tujeo), qee cov cai yuav tsum tau ua raws. Qhov tseem ceeb tshaj plaws, kev hloov pauv yuav tsum tsis txhob muaj kev nyuaj siab loj rau lub cev, yog li koj tsis tuaj yeem txo qis dua ntawm cov tshuaj raws li cov lej ntawm qhov kev txiav txim.

Ntawm qhov tsis sib xws, hauv thawj hnub ntawm kev tswj hwm, kev nce ntxiv ntawm cov tshuaj insulin yog qhov ua tau kom thiaj li yuav zam tau hyperglycemia. Thaum txhua lub cev hloov mus rau txoj kev siv tshuaj tshiab zoo tshaj plaws, koj tuaj yeem txo qhov koob tshuaj rau tus nqi ib txwm.

Txhua yam kev hloov pauv hauv txoj kev kho, tshwj xeeb yog cov cuam tshuam nrog kev hloov cov tshuaj nrog cov tshuaj tiv thaiv kab mob analogues, yuav tsum pom zoo nrog cov kws kho mob koom nrog, uas paub tias ib hom tshuaj txawv ntawm lwm thiab qhov twg zoo dua.

Kev ntsuas rau siv

Lantus thawj zaug tshwm sim hauv 2003 thiab txij thaum ntawd los suav hais tias yog ib qho ntawm cov duab zoo tshaj plaws ntawm tib neeg cov tshuaj insulin thiab tib lub sijhawm, qee qhov zoo tshaj yog qhov tseem ceeb dua.

Cov tshuaj nquag yog insulin glargine.

Cov txheej txheem ntim ntawm cov tshuaj suav nrog fwj nrog daws ntawm 10 ml (100 PIECES). Yog tias cov tshuaj tau nthuav tawm hauv daim cartridges, tom qab ntawd hauv ib pob muaj 5 daim cartridges ntawm 3 ml txhua.

Cov lus qhia rau kev siv

Lantus yog ib qho insulin ua ntev ntev, qhia rau kev siv hauv ntshav qab zib hom 1 thiab ntshav qab zib hom 2, thaum muaj peev xwm tiv thaiv lwm cov tshuaj insulin.

Qhov insulin no yog tsim los ntawm kev tsim kho caj ces thiab vim li ntawd, cov tshuaj molecule txais cov khoom uas tau tso tawm zuj zus, uas txiav txim siab cov khoom ntiag tug ntawm cov tshuaj tsis muaj qhov ua haujlwm siab tshaj, muab qhov cuam tshuam zoo thiab qeeb ntawm insulin thiab ua lub sijhawm ntev dua txhua yam ntawm insulin.

Cov tshuaj muaj lub sijhawm ntev ntawm qhov kev txiav txim vim qhov tseeb tias acidity ntawm txoj kev daws teeb meem tsawg thiab qhov no ua rau muaj kev cuam tshuam tsawg dua ntawm cov tshuaj hormones hauv cov nqaij mos. Raws li txoj cai, Lantus siv tau rau ib hnub, thiab qee kis txog 29 teev.

Nws yog ib qho tseem ceeb kom paub: Lantus yuav tsum tsis txhob tov nrog dej distilled, ntsev.

Cov tshuaj muaj qhov ua haujlwm ruaj khov.

Thawj qhov tshuaj thawj zaug rau cov tshuaj yog suav nrog tus kheej. Cov tshuaj yog ib txwm siv tshuaj subcutaneously 1 zaug hauv ib hnub, nyiam dua tib lub sijhawm, hauv lub xub pwg, plab lossis hauv tus ncej puab, thiab thaj chaw txhaj tshuaj yuav tsum hloov tas li.

Ntawm no koj yuav nyeem txog tag nrho cov nuances ntawm kev kho tshuaj insulin rau hom 1 thiab hom ntshav qab zib hom 2. Hom insulin zoo li cas rau lub sijhawm ua? Cov lus teb hauv peb tsab xov xwm.

Yog tias Lantus raug samfwm rau tus neeg mob uas muaj ntshav qab zib hom 1, tom qab ntawd cov tshuaj siv yog cov tshuaj tseem ceeb.

Ntawm ntshav qab zib hom 2, tus neeg mob yuav raug kho monotherapy lossis kev kho mob nyuaj nrog lwm cov tshuaj insulin.

Thaum tus neeg mob ntshav qab zib yuav tsum tau hloov los ntawm lwm hom tshuaj insulin rau Lantus, nws yuav tsum tau soj ntsuam xyuas cov piam thaj ntau ntau hnub kom thiaj kho tau thiab txiav txim siab tias nws xav tau cov tshuaj ntau npaum li cas.

Cov kev txwv tsis pub siv rau qhov tshuaj:

Tus neeg tsis qaug rau yeeb tshuaj,
Cov menyuam hnub nyoog (tsis pom zoo rau cov menyuam hnub nyoog qis dua 6 xyoo),
Kev Ntshav Qab Zib,
Cev xeeb tub thiab sijhawm tom qab lactation.

Raws li txoj cai, tag nrho cov tshuaj insulin ntawm tib neeg cov tshuaj hormones ua rau muaj kev phiv nkaus thaum pib kho thiab qhov no yog vim tus neeg mob ntshav qab zib tsis tuaj yeem suav txoj kev noj tshuaj uas nws xav tau thiab txhaj ntau dua qhov tsim nyog lossis tsawg dua. Hauv ob peb hnub, thaum ib tug neeg ua tib zoo saib xyuas cov koob tshuaj, kev hloov kho insulin, txhua yam kev qhia tsis zoo ploj mus:

Neeg tsis muaj zog
Xeev siab thiab ntuav
Mob taub hau
Hauv cov xwm txheej hnyav, thaum lub koob tau zoo dhau - kev nco qab, tsis nco qab.

Nws yog ib qho tseem ceeb kom paub: qee qhov teeb meem ntawm tus neeg mob ntshav qab zib tuaj yeem tsis zoo "teb" rau Kev Kho Mob Lantus. Yog li, ua ntej sau cov tshuaj, tus kws kho mob yuav tsum ua txhua qhov kev soj ntsuam uas tsim nyog txhawm rau txheeb xyuas kev txhim kho cov nyom.

Koj kuj yuav tsum tau ceev faj txog cov tshuaj rau cov neeg mob uas twb muaj keeb kwm ntawm lub raum, vim tias Niaj hnub no, cov nyhuv ntawm cov tshuaj rau ntawm kev ua haujlwm ntawm cov kabmob sab hauv tsis tau txiav txim siab.

Qee lub sijhawm tus neeg mob ntshav qab zib noj Lantus tuaj yeem pom tias nws li kev noj tshuaj insulin dheev pib pib muab cov txiaj ntsig tsis zoo thiab nws yuav tsum hloov kho cov koob tshuaj ntxiv dua. Tej yam no suav nrog:

Hloov chaw txhaj tshuaj
Theem siab ntawm cov tshuaj insulin rhiab heev,
Kev siv dag zog ntau dhau (tej zaum yuav ntev thiab nce ntxiv),
Lwm yam kab mob
Kev cuam tshuam ntawm cov zaub mov tsis zoo thiab noj cov zaub mov tsis raug cai,
Lub hwj chim kis tau tus mob,
Haus cawv
Mob raum
Kev phiv los sis cov tshuaj uas siv los kho lwm yam (uas tsis yog ntshav qab zib).

Cov tshuaj no yog qhia rau kev siv rau qee yam hauv qab no:

yog tias tus neeg kuaj mob ntshav qab zib hom 1 mob ntshav qab zib mellitus (insulin-dependant),
yog tias tus neeg kuaj mob ntshav qab zib hom 2 mob ntshav qab zib mellitus (non-insulin-dependant),

Nws yuav tsum raug sau tseg tias rau kev kho mob hom 2 mob ntshav qab zib mellitus, tshuaj tiv thaiv kab mob ntshav qab zib tau noj ntawm qhov ncauj. Txawm li cas los xij, hauv qee kis xwm txheej, cov neeg mob pib tiv thaiv lawv cov teebmeem. Thiab tom qab ntawd tus kws kho mob tau sau ntawv rau kev tswj hwm ntawm insulin subcutaneously.

Cov tshuaj Insulin Lantus tuaj yeem tsim kho rau cov neeg mob uas tsis muaj cov kab mob ntshav qab zib tsis yog insulin-tiv thaiv yog tias muaj mob lwm yam uas xav tau kev kho mob sai sai tau koom nrog qhov mob hauv qab.

Ua ntej siv cov insulin Lantus, cov lus qhia rau kev siv yuav tsum tau ua tib zoo kawm. Nws yuav tsum nco ntsoov tias cov tshuaj no yog txwv tsis pub txhaj tshuaj, vim tias nws tuaj yeem tsim kev txhim kho ntawm cov kev mob hnyav ntawm hypoglycemia.

Koj tuaj yeem hno cov tshuaj hauv qab no ntawm lub cev:

nyob rau hauv cov phab ntsa ntawm lub plab,
rau hauv cov nqaij deltoid
rau hauv cov leeg leeg pob tw.

Thaum ua kev tshawb fawb, tsis muaj qhov txawv txav ntawm lub siab ntawm cov tshuaj insulin txhaj rau hauv qhov sib txawv ntawm lub cev.

Cov tshuaj Insulin Lantus SoloStar muaj nyob rau hauv daim ntawv ntawm rab koob txhaj tshuaj, uas muaj cov roj hauv thawv nrog cov tshuaj insulin. Nws yuav siv tau tam sim ntawd. Hauv qhov no, tom qab kev daws teeb meem tiav lawm, tus kov yuav tsum tau muab pov tseg.

Cov tshuaj Insulin Lantus OptiKlik yog rab koob txhaj tshuaj uas haum rau rov siv dua tom qab hloov daim cartridge qub nrog tus tshiab.

Tujeo thiab Lantus yog cov tshuaj insulin hauv cov qauv ua kua rau kev txhaj tshuaj.

Ob qho tshuaj no yog siv rau hom ntshav qab zib hom 1 thiab ntshav qab zib hom 2, thaum cov normalization ntawm cov piam thaj tsis tuaj yeem ua tiav yam tsis muaj kev siv tshuaj insulin.

Yog tias cov tshuaj insulin, kev noj zaub mov tshwj xeeb, thiab nruj rau txhua tus txheej txheem tsis tuaj yeem pab ua kom cov ntshav qab zib nyob qis dua qhov tau tso cai, kev siv ntawm Lantus thiab Tujeo yog cov tshuaj noj. Raws li kev tshawb fawb hauv tsev kho mob tau pom tias, cov tshuaj no yog cov txiaj ntsig zoo ntawm kev saib xyuas cov ntshav qab zib kom qis.

Hauv cov kev tshawb fawb los ntawm kev ua cov tshuaj, Lub tuam txhab German Sanofi, kev tshawb fawb koom nrog 3,500 tus neeg tuaj yeem pab dawb.Txhua tus tau raug mob los ntawm kev tswj tsis tau tus mob ntshav qab zib ntawm ob hom.

Hauv rau lub hlis ntawm kev tshawb fawb hauv chav kho mob, plaub theem kev sim tau ua.

Hauv thawj theem thiab theem peb, tus yam ntxwv ntawm Tujeo txog kev noj qab haus huv ntawm hom 2 ntshav qab zib tau kawm.

Qeb plaub tau mob siab rau cawv ntawm Tujeo rau cov neeg mob ntshav qab zib hom 1. Raws li cov txiaj ntsig ntawm kev tshawb fawb, Tujeo lub siab ua haujlwm tau raug qhia.

Cov Yuav Tsum Tau Ua

Nws yog txwv tsis pub siv rau hauv cov neeg mob uas tsis nkag siab rau insulin glargine lossis ntu sib xyaw.
Kev ntshav siab.
Kev kho mob ntawm cov ntshav qab zib ketoacidosis.
Cov me nyuam qis dua 2 xyoos.

Ua tau qhov tsis zoo tshwm sim tsawg tsawg, cov lus qhia tau hais tias tej zaum yuav muaj:

lipoatrophy los yog lipohypertrophy,
kev ua xua (Quincke's edema, kev tsis haum, tshuaj bronchospasm),
mob nqaij thiab mob qeeb hauv lub cev ntawm sodium ions,
mob plab thiab qhov muag tsis pom kev.

Kev Hloov mus rau Lantus los ntawm lwm yam insulin

Yog hais tias tus mob ntshav qab zib tau siv cov tshuaj insulins-nruab nrab, tom qab ntawd thaum hloov mus rau Lantus, qhov ntau thiab kev hloov ntawm cov tshuaj tau hloov pauv. Kev hloov pauv cov kua dej yuav tsum tau nqa tawm hauv tsev kho mob nkaus xwb.

Hauv lub neej yav tom ntej, tus kws kho mob saib cov piam thaj, tus neeg mob lub neej, qhov hnyav thiab kho rau ntau pawg uas tau tswj hwm. Tom qab peb lub hlis, cov hauj lwm zoo ntawm cov tshuaj kho tau tuaj yeem tshawb xyuas los ntawm kev soj ntsuam ntawm glycated hemoglobin.

Kev qhia video:

Lub npe Kev Lag Luam	Yam khoom muaj sia	Chaw tsim tshuaj paus
Tujeo	insulin glargine	Lub teb chaws Yelemees, Sanofi Aventis
Levemire	tshuaj insulin	Lub Tebchaws Denmark, Novo Nordisk A / S
Islar	insulin glargine	Is Nrias teb, Biocon Txwv PAT "Ua Teb"

Hauv tebchaws Lavxias, txhua tus mob ntshav qab zib insulin-tau raug tshem tawm ntawm Lantus mus rau Tujeo. Raws li kev tshawb nrhiav, cov tshuaj tshiab muaj qhov txo qis ntawm kev noj qab haus huv hypoglycemia, tab sis hauv kev coj ua, cov neeg feem ntau yws tias tom qab hloov mus rau Tujeo lawv cov piam thaj tau dhia heev, yog li lawv raug yuam yuav Lantus Solostar insulin ntawm lawv tus kheej.

Levemir yog cov tshuaj zoo heev, tab sis nws muaj cov tshuaj sib txawv, txawm tias lub sijhawm ua haujlwm kuj yog 24 teev.

Aylar tsis ntsib insulin, cov lus qhia hais tias qhov no yog tib qho Lantus, tab sis cov chaw tsim khoom pheej pheej yig dua.

Insulin Lantus thaum cev xeeb tub

Cov kev tshawb fawb soj ntsuam ntawm Lantus nrog cov poj niam cev xeeb tub tsis tau ua. Raws li cov ntaub ntawv tsis raug cai, cov tshuaj tsis cuam tshuam loj heev hauv chav kawm ntawm cev xeeb tub thiab tus menyuam nws tus kheej.

Cov kev sim tau nrhiav rau ntawm cov tsiaj, thaum lub sijhawm nws tau ua pov thawj tias insulin glargine tsis muaj qhov phiv rau ntawm kev ua me nyuam.

Cev xeeb tub Lantus Solostar tuaj yeem siv tshuaj yog tias tsis muaj zog tiv thaiv NPH. Cov niam yav tom ntej yuav tsum saib xyuas lawv cov suab thaj, vim tias nyob rau thawj peb lub hlis, xav tau cov tshuaj insulin tuaj yeem txo qis, thiab hauv lub hlis thib ob thiab peb lub hlis.

Tsis txhob ntshai tsam pub niam mis rau tus menyuam noj, cov lus qhia tsis muaj cov ntaub ntawv uas Lantus tuaj yeem nkag mus rau niam mis tau.

Khaws cia li cas

Daim ntawv tso cai rau lub sijhawm Lantus yog 3 xyoos. Koj yuav tsum muab cia rau hauv qhov chaw tsaus tiv thaiv los ntawm tshav ntuj ntawm qhov kub ntawm 2 txog 8 degrees. Feem ntau qhov chaw zoo tshaj plaws yog tub yees. Hauv qhov no, nco ntsoov saib cov txheej txheem kub, vim tias qhov txias khov ntawm cov tshuaj insulin Lantus yog txwv!

Txij li thaum siv thawj zaug, cov tshuaj yuav khaws cia rau ib hlis nyob rau hauv qhov chaw tsaus ntawm qhov kub ntawm tsis ntau tshaj 25 degrees (tsis nyob hauv tub yees). Tsis txhob siv cov tshuaj insulin uas tas sijhawm.

Qhov twg yuav, nqe

Lantus Solostar yog tshuaj dawb los ntawm kev kho mob los ntawm kev kho mob endocrinologist. Tab sis nws tseem tshwm sim uas tus mob ntshav qab zib yuav tsum yuav cov tshuaj no ntawm nws tus kheej ntawm lub tsev muag tshuaj. Tus nqi nruab nrab ntawm cov tshuaj insulin yog 3300 rubles. Hauv Ukraine, Lantus tuaj yeem yuav rau 1200 UAH.

Tus kws kho ntshav qab zib hais tias nws yog ib qho zoo heev insulin, hais tias lawv qab zib yog khaws cia nyob rau hauv ib txwm txwv. Ntawm no yog cov neeg yuav hais dab tsi txog Lantus:

Feem ntau sab laug tsuas yog cov tshuaj xyuas qhov zoo.Ob peb cov neeg hais tias Levemir lossis Tresiba zoo dua rau lawv.

Sab sij huam

Yog tias muaj cov tsos mob zoo ib yam li cov lus tau hais hauv qab no, thov hu rau koj tus kws kho mob tam sim ntawd!

Kev mob ntshav qab zib tsawg tshaj, feem ntau tshaj qhov tsis xav tau ntawm kev kho mob insulin, tuaj yeem tshwm sim yog tias qhov koob tshuaj insulin ntau dhau piv rau qhov xav tau.

Cov kev tshwm sim tsis zoo hauv qab no los cuam tshuam nrog kev siv yeeb tshuaj uas tau pom thaum soj ntsuam kev soj ntsuam tau qhia hauv qab no rau cov chav kawm ntawm cov kab mob hauv kev ua kom tsawg zuj zus (feem ntau:> 1/10, feem ntau> 1/100 txog 1/1000 txog 1/10000 rau

Daim ntawv thov nta

Lantus tsis pom zoo rau kev kho mob ketoacidosis. Hauv cov xwm txheej zoo li no, kev pom zoo ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin.

Kev tswj hwm qhov tsis muaj txiaj ntsig nyob rau theem ntawm cov piam thaj hauv cov ntshav, zoo li yog tias muaj kev nyiam los txhim kho hypo- lossis hyperglycemia, ua ntej taug kev nrog kev kho ntawm cov tshuaj ntau npaum li cas, nws yog qhov yuav tsum tau kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem kev kho mob, qhov chaw ntawm kev saib xyuas ntawm cov tshuaj thiab cov txheej txheem ntawm kev txhaj tshuaj subcutaneous kom tsim nyog, muab txhua yam cuam tshuam nrog qhov teeb meem. Yog li ntawd, ua tib zoo saib xyuas tus kheej thiab khaws cov ntawv qhia nws tus kheej.

Hloov mus rau lwm hom lossis hom tshuaj insulin yuav tsum tau ua nyob ntawm kev saib xyuas mob nkeeg nruj me ntsis. Hloov pauv ntawm cov tshuaj, cov chaw tsim khoom, hom (NPH, ua yeeb yam luv luv, ua yeeb yam ntev, thiab lwm yam), keeb kwm (tsiaj, tib neeg, tib neeg insulin analogue) thiab / lossis cov txheej txheem ntau lawm yuav tsum tau hloov kho koob tshuaj.

Cov neeg mob uas cov neeg mob ntshav qab zib tsawg yuav muaj tej yam tseem ceeb hauv kev kho mob, xws li cov neeg mob uas mob hlab ntsha hauv cov hlab ntshav lossis cov hlab ntsha hlwb tsis zoo (muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb ntawm hypoglycemia), nrog rau cov neeg mob uas muaj hlwb ntau dua, tshwj xeeb yog tias lawv tsis tau txais kev kho mob nrog photocoagulation (muaj kev pheej hmoo dhau mus los ntawm qhov tsis pom kev vim yog ntshav tsis txaus), yuav tsum tau saib xyuas tshwjxeeb, thiab yuav tsum tau saib xyuas ntau dua thiab saib xyuas cov ntshav qabzib kom zoo.

Nco ntsoov tias hauv qee kis xwm txheej uas cov tsos mob ntawm lub zam ua ntej hypoglycemia tuaj yeem hloov pauv, dhau los ua suab tsawg lossis tsis tuaj rau hauv:

- cov neeg mob uas tau txhim kho txoj cai ntawm cov ntshav piam thaj,

- cov neeg mob uas tus mob ntshav qab zib tsawg zuj zus,

- Cov neeg laus laus,

- cov neeg mob tom qab hloov los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg insulin,

- cov neeg mob neuropathy,

- cov neeg mob mob ntshav qab zib,

- cov neeg mob ntsib mob hlwb,

cov neeg mob tau txais kev kho mob nrog lwm yam tshuaj (saib Kev Sib Koom Nrog nrog lwm cov tshuaj).

Lub sijhawm ntev ua haujlwm ntawm subcutaneous tswj hwm ntawm insulin glargine tuaj yeem qeeb qeeb tom qab kev txhim kho hypoglycemia.

Yog hais tias ib txwm los qis qis glycosylated hemoglobin qib raug sau tseg, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus lej muaj peev xwm tsim kev tshwm sim tsis nco qab txog kev mob ntshav qab zib (tshwj xeeb tshaj yog thaum tsaus ntuj).

Cov neeg mob ua raws li lub caij teem tseg, kev noj haus thiab kev noj haus, kev siv tshuaj insulin kom zoo thiab tswj kev pib ntawm cov tsos mob ntawm tus mob ntshav qab zib tsawg ua rau muaj kev txo qis hauv kev pheej hmoo ntawm lub qog ntshav qab zib.Qhov tseeb uas ua rau kom qhov mob ntshav siab tsis txaus txog qhov yuav tsum tau saib xyuas tshwj xeeb, raws li tej zaum yuav siv tshuaj kho cov tshuaj insulin. Tej yam no suav nrog:

- kev hloov chaw ntawm cov thawj coj ntawm insulin,

- kev rhiab ntxiv rau insulin (piv txwv li, thaum tshem tawm cov kev ntxhov siab),

- txawv txav, nce lossis lub sijhawm ua haujlwm lub cev ntev,

- cov kab mob sib xyaw nrog ntuav, zawv plab,

- ua txhaum kev noj haus thiab kev noj haus,

- skipped noj mov

- qee qhov kev cuam tshuam ntawm endocrine tsis zoo (piv txwv li, hypothyroidism, tsis muaj txiaj ntsig ntawm adenohypophysis lossis adrenal cortex),

- concomitant kev kho mob nrog lwm yam tshuaj (saib Kev sib cuam tshuam nrog lwm yam tshuaj).

Hauv cov kab mob sib kis, yuav tsum muaj kev saib xyuas ntshav qabzib ntau dua. Feem ntau, kev txheeb xyuas yog ua rau muaj cov ketone lub cev nyob hauv cov zis, thiab kev kho ntawm cov tshuaj ntau npaum li cas ntawm cov tshuaj insulin kuj tseem xav tau. Qhov kev xav tau rau insulin feem ntau nce. Cov neeg mob ntshav qab zib hom 1 yuav tsum txuas ntxiv kev haus tsawg kawg yog ib qho me me ntawm carbohydrates, txawm tias lawv muaj peev xwm noj zaub mov ntau hauv tsawg los yog noj tsis tau txhua yam yog tias lawv ntuav, thiab lwm yam. Cov neeg mob no yuav tsum tsis txhob tso tseg txoj kev siv tshuaj insulin.

Kev kho mob yuam kev tau tshaj tawm thaum lwm cov insulins, tshwj xeeb tshaj yog cov insulins luv luv, tau raug yuam cai siv es tsis txhob siv cov glargine insulin. Daim paib insulin yuav tsum tau kuaj xyuas txhua zaus ua ntej txhaj tshuaj kom tsis txhob muaj qhov ua yuam kev kho mob ntawm insulin glargine thiab lwm yam insulins.

Kev sib xyaw ntawm Lantus thiab pioglitazone

Cov neeg muaj lub plawv tsis nco qab tau qhia thaum pioglitazone siv nrog kev siv tshuaj insulin, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kev pheej hmoo rau lub plawv tsis ua haujlwm. Qhov no yuav tsum tau coj mus rau hauv tus account thaum sau ntawv ntawm kev sib xyaw ntawm pioglitazone thiab Lantus. Thaum noj tshuaj ua ke nrog cov tshuaj no, nws yog ib qhov tsim nyog los saib xyuas cov neeg mob hauv kev sib piv nrog cov tsos mob tshwm sim thiab cov tsos mob ntawm lub plawv tsis ua hauj lwm, hnyav ntxiv thiab edema.

Pioglitazone yuav tsum tsis ua mus ntxiv yog tias muaj qhov tsis txaus ntseeg ntawm cov tsos mob ntawm lub plawv tsis ua haujlwm.

Kev cuam tshuam rau kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog cov txheej txheem nyuaj

Tus neeg mob lub peev xwm mloog zoo thiab teb sai sai rau lwm qhov sab nraud tuaj yeem ua tsis tau zoo vim qhov kev txhim kho ntawm hypoglycemia lossis hyperglycemia, lossis, piv txwv li los ntawm qhov muag tsis pom kev. Qhov no tuaj yeem ua kev pheej hmoo nyob rau qee qhov xwm txheej uas qhov peev xwm no yog qhov tseem ceeb tshwj xeeb (piv txwv, thaum tsav tsheb lossis thaum ua haujlwm nrog cov txheej txheem nyuaj).

Tus neeg mob yuav tsum tau txais kev ceeb toom qhia txog kev ceev faj kom tsis txhob muaj kev txhim kho hypoglycemia thaum tsav tsheb. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov neeg mob uas tau txo qis lossis tsis paub txog cov kev hem thawj ntawm tus mob ntshav qab zib tsawg, nrog rau cov neeg mob uas feem ntau muaj kev mob ntshav qab zib. Kev ua tib zoo saib xyuas yuav tsum tau muab rau kev muaj peev xwm ntawm kev tsav tsheb los yog ua haujlwm nrog cov txheej txheem nyuaj hauv cov xwm txheej no.

Daim ntawv tso tawm

10 ml hauv ib lub raj mis pob tshab, tsis muaj kob (hom I). Lub raj mis tau ntim nrog lub chlorobutyl nres, khij nrog lub hau txhuas thiab npog nrog lub hau tiv thaiv uas ua los ntawm polypropylene. 1 lub raj mis tau muab tso ua ke nrog cov lus qhia rau kev siv rau hauv lub thawv ntawv thawv.

3 ml ib daim cartridge ntawm cov iav ntshiab, tsis muaj kob (hom I). Lub pob txha taub tau ntim rau ntawm ib sab nrog lub bromobutyl nres thiab crimped nrog txhuas hau, ntawm qhov tod tes nrog bromobutyl plunger. 5 daim cartridges rau qhov hlwv pob ntawm PVC zaj duab xis thiab txhuas ntawv ci.1 blister sawb ntim tau muab tso ua ke nrog cov lus qhia rau kev siv rau hauv thawv ntawv thawv.

3 ml txhua qhov hauv ib qho ntshiab, iav iav cartridge (hom I). Lub pob txha taub tau ntim rau ntawm ib sab nrog lub bromobutyl nres thiab crimped nrog txhuas hau, ntawm qhov tod tes nrog bromobutyl plunger. Lub pob txha taub hau yog mounted hauv rab koob uas siv pov tseg

Cia rau cov neeg mob

Khaws ntawm qhov kub ntawm + 2 ° C rau + 8 ° C hauv qhov chaw tsaus.

Khaws tsis ncav cuag ntawm cov menyuam yaus.

Tsis khov! Tsis txhob cia lub ntim ntim rau hauv lub chwv khov thiab cov khoom khov.

Tom qab pib siv, khaws cia hauv qhov kub tsis dhau + 25 ° C hauv pob ntawv cardboard (tab sis tsis nyob hauv tub yees).

Hnub tas sij hawm

Kev daws ntawm cov tshuaj rau hauv hwj yog 2 xyoos.

Kev daws ntawm cov tshuaj hauv daim cartridges thiab hauv SoloStarSt koob txhaj tshuaj yog 3 xyoos.

Tom qab hnub tas sijhawm, cov tshuaj tsis tuaj yeem siv.

Lus Cim: lub txee lub neej ntawm cov tshuaj los ntawm lub sijhawm siv thawj zaug yog 4 lub lis piam. Nws raug nquahu kom khij hnub ntawm thawj zaug tshem tawm cov tshuaj ntawm daim ntawv lo.