Rosart: cov lus qhia rau kev siv, taw qhia, xyuas thiab analogues

Peb cov neeg nyeem tau siv Aterol ua tiav kom qis cov roj (cholesterol). Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Rosart - cov tshuaj cuam tshuam nrog statins, siv los txo cov roj hauv cov ntshav. Cov tshuaj Rosart ua cov khoom xyaw dhia ua ke muaj cov rosuvastatin. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm 5, 10, 20 thiab 40 mg ntsiav tshuaj nyob rau hauv daim ntawv ntawm Actavis pawg hauv Iceland. Rosart yog dav siv los kho hypercholisterinemia.

• Kev qhia rau kev siv tshuaj
• Kev noj haus thiab kev kho mob statin
• Rosart kev cai teem caij
• Thaum Twg Kuv Siv Tsis Tau Rosart?
• Cev xeeb tub thiab pub mis rau menyuam noj
• Siv Rosart nrog ceev faj
• Kev phiv tshuaj
• Analogues ntawm cov tshuaj

Rosart muaj cov tshuaj hauv qab no:

• txo qis roj - lipoproteins tsawg ntom,
• txos theem ntawm cov roj (cholesterol) A - lipoproteins tsawg kawg,
• txo tag nrho cov roj (cholesterol) thiab triglycerides hauv cov ntshav,
• txo qis roj - liproteins ntau ntom,
• lowers ntau qhov sib piv ntawm cov roj (cholesterol) - siab thiab qis ntawm cov lipoproteins,
• cuam ​​tshuam rau theem ntawm alipoproteins A thiab B.

Kev siv hypolipidemic ntawm Rosart ncaj qha nyob ntawm kev siv ntau npaum li cas. Tom qab pib ua haujlwm ntawm Rosart, txoj kev kho mob tshwm sim tom qab ib lub lim tiam, tom qab ob lub lis piam nws nce mus txog 90%, thiab tom qab plaub lub lis piam ntawm kev siv cov tshuaj siab tshaj plaws tau tiav thiab tseem nyob rau theem no. Cov tshuaj no yog nqus rau hauv lub plab zom mov, metabolized hauv daim siab thiab ua rau ntau dua los ntawm txoj hnyuv, thiab kom tsawg dua los ntawm lub raum.

Dab tsi pab Rosart?

Rosart, duab ntawm cov ntsiav tshuaj

Kev qhia rau kev siv tshuaj muaj xws li no:

• thawj hypercholesterolemia los yog ua ke hyperlipoproteinemia,
• kab mob hypercholesterolemia, tsis yog khoom noj rau txoj kev kho kev noj haus thiab lwm txoj kev siv tshuaj tsis yog,
• muaj zog concentration ntawm triglycerides,
• thiaj li yuav ua rau qeeb qhov muaj mob ntawm atherosclerosis,
• raws li thawj qhov kev tiv thaiv ntawm cov teeb meem feem ntau ntawm cov kab mob plawv (mob hlab ntsha tawg, mob plawv nres, ischemia).

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Rosart yog muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab-xim ntsiav tshuaj: biconvex, ntawm ib sab yog sau "ST 1" rau cov ntsiav tshuaj dawb puag ncig, "ST 2" thiab "ST 3" rau cov ntsiav tshuaj puag ncig liab, "ST 4" ntawm cov duab liab dawb zoo li tus kheej (hauv cov hlwv: 7 pcs., hauv daim duab cardboard 4 lub hlwv, 10 pcs., hauv duab los qhia 3 los yog 9 hlwv, 14 pcs., hauv daim duab los qhia 2 los yog 6 lub hlwv).

1 ntsiav tshuaj muaj:

• cov tshuaj nquag: rosuvastatin calcium - 5.21 mg, 10.42 mg, 20.84 mg lossis 41.68 mg, qhov no yog sib npaug nrog cov ntsiab lus 5 mg, 10 mg, 20 mg lossis 40 mg ntawm rosuvastatin, ntsig txog,
• Cov khoom siv pabcuam: lactose monohydrate, microcrystalline cellulose (hom 102), calcium hydrogen phosphate dihydrate, crospovidone (hom A), magnesium stearate,
• zaj duab xis txheej muaj pes tsawg leeg: cov ntsiav tshuaj dawb - Opadry dawb II 33G28435 (titanium dioxide, hypromellose-2910, lactose monohydrate, triacetin, macrogol-3350), cov ntsiav tshuaj xim liab - Opadray liab II 33G240007 (titanium dioxide, hypromellose-2910, lactose monohydrate, triacetin , macrogol-3350, zas xim carmine liab).

Cov lus qhia rau kev siv Rosart, haus ntau npaum

Rosart tuaj yeem nqa tau txhua lub sijhawm ntawm lub hnub, tsis hais cov zaub mov. Nws yog ib qho tseem ceeb rau tus neeg mob thaum kho mob kom ua raws li cov khoom noj nruj me ntsis, cov ntsiab lus ntawm uas yog qhov tsis txaus ntseeg ntawm cov khoom noj muaj roj.

Qhov ntau npaum yog xaiv nruj me ntsis thiab tag nrho nyob ntawm yam xws li kuaj ntsuas cov roj (cholesterol), cov kab mob plawv thiab cov kab mob lub plab.

Thaum pib ntawm kev kho mob hauv chav kawm, qhov tshuaj zoo rau txhua hnub yog 5 lossis 10 mg. Kev ntsuam xyuas ntawm kev kho mob yog nqa tawm plaub lub lis piam tom qab: yog tias theem ntawm "zoo" cov roj (cholesterol) tsis tau zoo li qub, ces cov tshuaj ntau ntxiv rau 20 mg, thiab yog tias tsim nyog, txog 40 mg.

Yog hais tias tus neeg mob siv ntau tshaj qhov tau tso cai, tom qab ntawd nws xav tau kev saib xyuas kev kho mob tas li, vim tias nws muaj qhov pheej hmoo loj ntawm kev tshwm sim tsis zoo.

Cov lus qhia rau kev siv Rosart tshwj xeeb tshaj yog kos sai sai rau kev sib cuam tshuam yeeb tshuaj nrog lwm cov tshuaj:

1. Yog tias tus neeg mob noj cov tshuaj tiv thaiv kab mob Cyclosporine, ces koob tshuaj Rosart yog 5 mg.

2. Cov tshuaj Hemofibrozil muaj cov tshuaj zoo sib xws nrog Rosar, yog li ob qho tshuaj yuav tsum noj tsawg lossis nruab nrab tshuaj.

3. Cov tshuaj tiv thaiv kab mob (cov tshuaj tiv thaiv kab mob rau cov tshuaj tiv thaiv kab mob, cov tshuaj tiv thaiv - Agenerase, Crixivan, Virasept, Aptivus) thaiv cov enzyme lub luag haujlwm rau kev tawg ntawm polyproteins. Yog li, yog tias tus neeg mob siv Rosart nrog txoj kev kho no, tom qab ntawd qhov kev ua tau zoo ntxiv rau peb zaug. Hauv qhov no, qhov ntau kawg ntawm cov tshuaj lipid-txo qis yuav tsum tsis pub ntau tshaj 10 mg.

Cov tshuaj yuav tsum tau muab ntxuav nrog qhov dej txaus, ntxo cov ntsiav tshuaj tsis pom zoo.

Contraindications thiab kev noj ntau dhau

Thaum lub raum ua mob hnyav, lub siab ua haujlwm kom mob siab thiab mob leeg, cov ntsiav tshuaj tsis yog kws kho mob. Rosart tseem tsis pom zoo rau cov poj niam npaj cev xeeb tub.

Lwm yam kev sib kis - txhua lub sijhawm ntawm cev xeeb tub, lactation (pub niam mis) thiab menyuam yaus hnub nyoog qis dua 18 xyoo.

Qhov ntau tshaj yog muab tsis tau yog tias tus neeg mob ua mob hypothyroidism (tsis muaj cov thyroid hormones txaus) lossis haus dej haus cawv tsis zoo (hauv qhov no, qhov tshuaj kho mob me me tau pom zoo lossis cov tshuaj tsis tau siv txhua). Cov ntsiav tshuaj tau sau ntawv nrog kev ceev faj hauv cov neeg mob uas ib tus ntawm cov txheeb ze muaj kev puas tsuaj los ntawm cov leeg nqaij. Rau cov neeg ntawm haiv neeg ntawm haiv neeg Moob hom, kev noj tshuaj tau sau tseg raug tshuaj tsawg kawg nkaus.

Muaj qee kis, kev noj cov tshuaj tuaj yeem ua rau cov kev mob tshwm sim tsis zoo hauv qab no:

• kev ua xua ua rau daim tawv nqaij liab, ua pob khaus, ua pob khaus,
• kiv taub hau, mob taub hau, leeg tsis muaj zog,
• ua txhaum ntawm endocrine muaj nuj nqi, tshwm sim hauv kev txhim kho ntawm cov ntshav qab zib hom 1,
• nkees sai thiab qaug zog,
• ntxiv ntshav siab, palpitations.

Tus neeg mob tsis raug pom zoo los ntawm nws tus kheej kho cov tshuaj upward. Txwv tsis pub, tshaj tawm cov tsos mob tej zaum yuav pib:

• xeev siab, ntuav, tso quav tsis taus,
• mob plab
• pallor ntawm daim tawv nqaij, ploj mus rau hauv kev nco qab,
• ua txhaum ntawm kev ua pa thiab lub plawv dhia.

Yog tias cov xwm txheej no tshwm sim, yuav tsum tau saib xyuas sai, thiab ua ntej cov kws kho mob tuaj txog, yaug tus neeg mob lub plab.

Cov Tshuaj Hauv Tshuaj

Rosart yog cov tshuaj los ntawm cov pab pawg ntawm statins nrog lipid-txo qis kev ua si. Nws cov khoom xyaw ua haujlwm, rosuvastatin, yog qhov xaiv sib tw inhibitor ntawm 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), ib qho enzyme uas hloov HMG-CoA rau mevalonate, lub teeb tsa rau cov roj (cholesterol).

Los ntawm nce tus naj npawb ntawm qis lipoprotein receptors (LDL) nyob rau saum npoo ntawm hepatocytes, rosuvastatin ua rau kom muaj kev nce siab thiab catabolism ntawm LDL, inhibits kev sib txuas ntawm cov lipoproteins tsawg tsawg (VLDL) thiab txo tag nrho cov lej ntawm LDL thiab VLDL. Nws txo qis ntau ntawm cov roj (LDL) cov roj cholesterol, tag nrho cov roj (cholesterol), triglycerides (TG), VLDL cov roj (cholesterol), TG-VLDL, cov roj (tsis muaj HDL) (cov lipoproteins ntau ntom), apolipoprotein B (ApoV). Ua rau muaj kev nce ntxiv hauv cov kev xav ntawm HDL cov roj cholesterol thiab ApoA-I. Txo qhov feem pua ​​ntawm cov roj cholesterol-LDL rau cov roj cholesterol-HDL, cov roj (cholesterol) tag nrho cov roj (cholesterol)-HDL, cov roj (cholesterol) tsis-HDL rau roj HDL roj, apolipoprotein B (ApoB) rau apolipoprotein A-I (ApoA-I).

Kev siv tshuaj tiv thaiv hypolipidemic ntawm Rosart yog ncaj qha nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj tso cai. Cov txiaj ntsig kho tshwm sim tom qab thawj lub lim tiam ntawm kev kho, tom qab ob lub lis piam nws nce mus txog 90% ntawm cov nyhuv siab, thiab los ntawm lub lim tiam thib plaub - 100% thiab nyob tas mus li. Rosuvastatin yog qhia rau kev kho mob hypercholesterolemia tsis muaj / nrog hypertriglyceridemia, tsis hais tus tub lossis ntxhais, hnub nyoog lossis haiv neeg ntawm tus neeg mob, suav nrog cov neeg mob ntshav qab zib mellitus thiab tsev neeg hypercholesterolemia. Cov txiaj ntsig ntawm kev tshawb fawb pom tias thaum noj Rosart ntawm ib koob tshuaj 10 mg rau hom IIa thiab IIb hypercholesterolemia (Fredrickson kev faib tawm) nrog qhov nruab nrab qhov ntsuas LDL cov roj cholesterol ntawm 4.8 mmol / L, LDL cov roj cholesterol nce mus txog qhov tseem ceeb ntawm qis dua 3 mmol / L hauv 80 % ntawm cov neeg mob. Nrog homozygous tsev neeg hypercholesterolemia, qhov nruab nrab qis ntawm LDL cov qib roj cholesterol nrog rosuvastatin ntawm ib koob ntawm 20 mg thiab 40 mg yog 22%.

Ib qho txiaj ntsig zoo ntxiv hauv kev sib xyaw ntawm Rosart nrog nicotinic acid ntawm koob tshuaj ntawm 1000 mg lossis ntau dua ib hnub (hauv kev cuam tshuam rau qhov nce ntawm HDL cov roj cholesterol) thiab fenofibrate (hauv qhov sib piv rau qhov txo qis hauv cov concentration ntawm TG) tau sau tseg.

Cov Tshuaj Pharmacokinetics

Tom qab noj tshuaj C_max (qhov siab tshaj plaws) ntawm rosuvastatin hauv cov ntshav ntshav tau mus txog tom qab 5 teev. Nws lub cev kis raug nce nyob rau hauv cov feem thiab cov tshuaj noj. Kev tsis raug cai txog ntawm kev tsis raug cai yog txog 20%. Cov niaj hnub sib cav pharmacokinetic tsis hloov pauv.

Kev khi rau cov ntshav plasma protein (kom ntau dua li qub nrog albumin) yog kwv yees li 90%. Kev nqus tuaj yeem ntau tshwm sim hauv lub siab. V_d (ntim khoom ntim) - 134 l. Cov tshuaj tau dhau lub placental barrier.

Nws yog cov-txheej txheem tsis-rau rau isoenzymes ntawm cytochrome P system₄₅₀Cov. Li 10% ntawm rosuvastatin yog biotransformed hauv daim siab. Cov txheej txheem ntawm rosuvastatin uptake nyob rau hauv daim siab ua rau muaj kev koom tes nrog ib daim nyias muaj nyias daim nyias nyias - polypeptide, uas thauj cov organic anion (OATP) 1B1 thiab siv sij hawm tseem ceeb hauv nws cov kev ua rau mob hepatic. Isoenzyme CYP2C9 yog isoenzyme lub ntsiab ntawm cov metabolism hauv rosuvastatin, kom tsawg dua CYP3A4, CYP2C19 thiab CYP2D6.

Cov khoom noj hluav taws xob tseem ceeb ntawm rosuvastatin yog cov tshuaj tsis haum rau lactone metabolites thiab N-desmethyl, uas yog kwv yees li 50% tsis tshua muaj siab tshaj li rosuvastatin. Kev txwv tsis pub ntawm circulating HMG-CoA reductase tau lees paub los ntawm ntau dua 90% pharmacological kev ua si ntawm rosuvastatin, qhov seem

10% - kev ua si ntawm nws cov khoom noj khoom haus.

Hauv qhov tsis hloov pauv, kwv yees li 90% ntawm qhov koob tshuaj ntawm Rosart yog tawm los ntawm txoj hnyuv, thiab cov seem los ntawm lub raum. T_1/2 (ib nrab-lub neej) - txog 19 teev, nrog rau qhov nce ntxiv ntawm cov tshuaj, nws tsis hloov pauv. Plasma tshem tawm qhov ntau kawg 50 l / teev.

Nrog cov mob me thiab mob hnyav ntawm lub raum tsis ua haujlwm, qhov hloov pauv tseem ceeb ntawm qib siab ntawm rosuvastatin hauv cov ntshav ntshav lossis N-desmethyl tsis tshwm sim. Hauv kev mob tsis zoo hauv lub raum nrog creatinine tshem tawm (CC) tsawg dua 30 ml / min, cov ntsiab lus ntawm rosuvastatin hauv ntshav nce ntxiv 3 zaug, N-desmethyl - 9 zaug. Hauv cov neeg mob ntawm kev mob hemodialysis, kev nqus ntawm rosuvastatin hauv ntshav nce ntxiv txog li 1/2.

Ntawm ntau theem ntawm daim siab ua haujlwm (7 cov ntsiab lus thiab hauv qab ntawm Tus Menyuam - Pugh nplai), nce hauv T_1/2 tsis qhia npe. Elongation T_1/2 rosuvastatin yog 2 zaug pom hauv cov neeg mob uas lub siab tsis ua haujlwm ntawm 8 thiab 9 lub ntsiab lus ntawm qhov ntsuas Me-Pugh. Nrog rau ntau qhov qhia ua kom lub siab ua haujlwm tsis zoo, tsis muaj kev paub nrog kev siv tshuaj.

Cov tshuaj pharmacokinetics ntawm rosuvastatin tsis muaj kev cuam tshuam loj hauv kev kho mob rau poj niam txiv neej thiab hnub nyoog ntawm tus neeg mob.

Kev sib tw haiv neeg cuam tshuam rau qhov sib txawv ntawm pharmacokinetic ntawm Rosart. Lub plasma AUC (tag nrho qhov kev xav) ntawm rosuvastatin hauv Suav thiab Nyij Pooj yog 2 npaug ntau dua li cov neeg ntawm Tebchaws Europe thiab North Asmeskas. C_max thiab AUC hauv Isdias Asmesliskas thiab cov neeg sawv cev ntawm haiv neeg Mongoloid ntawm qhov nruab nrab nce li 1.3 npaug.

Kev ntsuas rau siv

• hypertriglyceridemia (hom IV raws li Fredrickson) - raws li kev txhawb rau kev noj zaub mov,
• thawj hypercholesterolemia (hom IIa raws li Fredrickson), suav nrog kev mob heterozygous kab mob hypercholesterolemia, lossis sib xyaw (sib xyaw) hyperlipidemia (hom IIb raws li Fredrickson) - raws li kev pabcuam rau kev noj zaub mov zoo, kev tawm dag zog thiab kev poob phaus,
• homozygous daim ntawv ntawm kev tiv thaiv kab mob hypercholesterolemia thaum tsis muaj lub txiaj ntsig ntawm kev noj zaub mov zoo thiab lwm yam kev kho mob txhawm rau txo qis ntawm lipid concentration (suav nrog LDL-apheresis) lossis nrog tus neeg tsis kam rau hom kev kho mob,
• kev tiv thaiv kab mob plawv mob plawv (mob plawv, mob hlab ntsha tawg, mob hlab ntsha tawg hauv hlab ntsha) hauv cov neeg laus uas tsis muaj cov cim kev mob plawv (CHD), tab sis nrog kev ntsuas ua ntej rau nws txoj kev txhim kho (hnub nyoog rau cov txiv neej laus dua 50 xyoo thiab rau cov poj niam laus dua 60 xyoo, concentration C -Cov protein tsis zoo 2 mg / l thiab ntau dua nyob rau ntawm qhov tsawg kawg ntawm ib qho kev pheej hmoo ntxiv: mob ntshav siab, ntshav roj HDL tsawg, pib mob ntshav siab hauv lub plawv hauv keeb kwm tsev neeg, haus luam yeeb).

Tsis tas li ntawd, Rosart yog tshuaj ntxiv rau kev noj haus rau cov neeg mob uas tau pom tias kev kho mob kom txo qis tag nrho cov roj (cholesterol) thiab LDL cov roj (cholesterol) hauv qhov txhaws txhawm rau kom qeeb ntawm cov mob atherosclerosis.

Rosart analogs, cov npe tshuaj

Cov tshuaj tiv thaiv kev puas tsuaj muaj ntau yam tshuaj tiv thaiv kab mob nrog cov khoom zoo sib xws. Txawm li cas los xij, nws tsis pom zoo kom hloov ib qho tshuaj nrog lwm tus ntawm nws tus kheej (piv txwv, vim muaj nqi sib txawv). Qhov no tuaj yeem ua rau qhov tseeb tias cov cuab yeej siv kho mob uas xaiv tau tuaj yeem muaj qhov tsis zoo rau lub cev, qhia kev phiv los sis tsis muaj cov kev kho kom zoo.

Cov qauv zoo sib xws ntawm Rosart:

1. Akorta. Qhov no yog qhov lipid-txo qis tus neeg sawv cev uas ua rau muaj qhov nce ntxiv ntawm cov neeg lipoprotein tsawg, uas ua rau txo qis hauv cov concentration ntawm cov teeb meem roj cholesterol.
2. Neeg Coob. Cov ntsiav tshuaj kuj tseem qhia lawv cov nyhuv hauv lub siab (muaj kev zom zaub mov tsis muaj ntshav lipoproteins nrog rau kev tsim cov roj cholesterol). Kev nce ntxiv ntawm cov neeg mob hepatic rau ntawm cov xoos ntawm tes ua rau lub ntsej muag muaj zog catabolism thiab ntes cov lipoproteins tsawg kawg.

Tsis tas li ntawd analogues suav nrog cov tshuaj - Rosucard, Rosistark, Tevastor.

Tseem Ceeb - Rosart cov lus qhia rau kev siv, tus nqi thiab tshuaj xyuas tsis cuam tshuam rau cov qauv (analogues) thiab tsis tuaj yeem siv los ua cov lus qhia rau kev siv tshuaj ntawm cov tshuaj zoo sib xws lossis siv tau. Txhua txhua teem sijhawm kho yuav tsum ua los ntawm kws kho mob. Thaum hloov Rosart nrog tshuaj tiv thaiv kab mob, nws yog qhov tseem ceeb kom tau txais kev pab tswv yim tshwj xeeb; koj yuav tsum tau pauv chav kho mob, noj tshuaj, thiab lwm yam. Tsis txhob noj tshuaj rau tus kheej!

Kev tshuaj xyuas ntawm cov kws kho mob txog Rosart yog sib xyaw. Ntawm qhov muaj qhov zoo, qhov kev ua tau zoo thiab kav ntev uas cov kev txhim kho hauv lub sijhawm luv luv tuaj yeem pom. Ntawm qhov tod tes, nws yuav nyuaj rau xaiv kev noj tshuaj rau ib tug neeg. Cov neeg mob kuj ntsib kev tsis yooj yim thaum kho, vim tias lawv yuav tsum tso cov nqaij kom tsw qab, kom paub zoo txawm tias muaj pes tsawg.

Sab sij huam

Cov kev mob tshwm sim muaj tsawg. Cov kev mob tshwm sim nram qab no yuav tsum tau qhia rau koj tus kws kho mob yog tias lawv mob siab lossis txhawm rau:

Cov kev mob tshwm sim tom qab no muaj ntau dua. Yog tias muaj, koj yuav tsum tsis txhob noj Rosart thiab sab laj tus kws kho mob tam sim ntawd. Tej kev phiv tshuaj suav nrog:

• mob leeg los yog tsis muaj zog
• npaws,
• mob hauv siab
• daj tawv nqaij lossis qhov muag,
• tsaus zis
• mob mob sab xis rau hauv plab sab xis,
• xeev siab
• nkees heev
• ntshav txawv lossis doog ntshav
• tsis qab los noj mov
• cov tsos mob khaub thuas zoo li mob khaub thuas,
• mob caj pas, ua daus no, los yog lwm yam cim ntawm kis.

Yog tias muaj ib qho kev txhaum ntawm kev fab yuas tshwm sim, koj yuav tsum hu rau kev kho mob ceev ceev:

• ua pob
• urticaria,
• khaus,
• ua pa nyuaj lossis nqos,
• o tuaj ntsej muag, caj pas, tus nplaig, daim di ncauj, qhov muag, tes, taw, pob taws lossis sab ceg qis,
• txhaws qa
• loog lossis tingling hauv cov ntiv tes thiab ntiv taw.

Cov lus qhia rau kev siv Rosart

Hauv cov lus qhia rau kev siv, Rosart 10 mg hais tias cov tshuaj no noj ntawm qhov ncauj tsis tas ua ntej sib tsoo. Haus cov tshuaj uas muaj kua txaus, nyiam haus dej. Kev noj tshuaj yog ywj pheej ntawm kev noj zaub mov.

Raws li Rosart cov lus qhia rau kev siv, 10 milligrams, cov tshuaj yuav tsum tau noj nrog qhov tsawg kawg yog 5 milligrams lossis 10 milligrams, txawm tias tau txais txiaj ntsig ntau ntawm lwm yam statins yav tas los. Qhov kev xaiv ntawm cov tshuaj thawj zaug nyob ntawm:

• theem roj
• theem ntawm kev pheej hmoo ntawm lub plawv nres lossis hlab ntsha tawg,
• ua kom yooj yim rau cov tshuaj ntawm cov tshuaj.

Nrog rau kev pib thawj zaug ntawm 5 milligrams, tus kws kho mob tuaj yeem muab ob npaug tshuaj ntxiv no rau 10 milligrams, thiab tom qab ntawd nce ntxiv rau 20 milligrams thiab 40 milligrams, yog tias tsim nyog.

Plaub lub lis piam yuav tsum ncua ntawm kev hloov kho koob tshuaj. Qhov tshuaj ntau ntau rau txhua hnub yog 40 milligrams. Cov koob tshuaj no tsuas yog kho rau cov neeg mob ntshav siab thiab muaj qhov pheej hmoo mob plawv lossis mob hlab ntsha tawg, qhov ntau npaum ntawm 20 milligrams txaus los txo cov ntshav roj hauv cov ntshav siab.

Thaum muab tshuaj rau kom txo qis plawv nresmob stroke lossis lawv
teeb meem kev noj qab haus huv, qhov pom zoo txhua hnub koob tshuaj yog 20 mg. Qhov ntau npaum li cas yuav raug txo tsawg dua yog tias tus neeg mob tau muaj cov tsos mob uas muaj nyob hauv daim ntawv teev npe ntawm contraindications.

Koob tshuaj rau cov menyuam yaus hnub nyoog kaum txog kaum xya xyoo - kev siv tshuaj ntau npaum li qub yog 5 milligrams, qhov tshuaj tiv thaiv txhua hnub yog 20 mg. Cov tshuaj yuav tsum tau noj ib hnub ib zaug.

Rosart tshuaj, raws li cov lus qhia rau kev siv, hauv qhov ntau npaum ntawm 40 mg tsis pom zoo rau menyuam yaus.

Kev cuam tshuam nrog lwm yam tshuaj

Rosart, thaum noj nrog qee yam tshuaj, tuaj yeem ua rau tsis txaus siab qhov kev tsis haum siab:

• Rosart txoj kev txais tos nrog Cyclosporine - Cov tshuaj kawg stimulates ntau nce nyob rau hauv lub cev raug rosuvastatin, vim li no, cov neeg mob uas tau muab tshuaj Cyclosporine kho yuav tsum siv Rosart kom tsawg li tsawg - tsis ntau tshaj 5 milligrams ib hnub.
• Hemofibrozil (Gemfibrozil) - ua rau muaj kev cov kabmob rosuvastatin ntau ntxiv. Vim tias pom muaj kev pheej hmoo ntawm myopathy / rhabdomyolysis, kev sib xyaw ua ke ntawm Rosart thiab Gemfibrozil yuav tsum zam. Qhov ntau kawg noj yuav tsum tsis pub tshaj 10 milligrams ib hnub.
• Protease inhibitors - kev siv sib xyaw ua ke ntawm Rosart nrog qee yam tshwj xeeb protease inhibitors hauv ritonavir muaj ntau yam cuam tshuam rau rosuvastatin, thiab ntau dua qhov tseeb ntawm cov nyhuv ntawm lub cev ntawm lub cev. Protease Inhibitionitors hauv kev sib txuas ua ke: lopinavir / ritonavir thiab atazanavir / ritonavir tuaj yeem ua rau kom muaj kev phom sij rau cov kab mob rosuvastatin mus txog peb zaug. Rau cov kev sib txuam no, cov tshuaj ntawm Rosart yuav tsum tsis pub tshaj 10 milligrams ib hnub ib zaug.

Kev qhia rau kev siv tshuaj

Rosart daim ntawv thov yog qhia nyob rau hauv cov xwm txheej hauv qab no:

• Kev nce qib hauv cov qib roj cholesterol thawj, suav nrog tus kab mob los ntawm caj ces, nrog rau daim ntawv sib xyaw.

• Txhawb triglycerides hauv cov ntshav.
• Nrog atherosclerosis - kom qeeb qhov muaj mob ntawm cov kab mob.
• Kev tiv thaiv ntawm ischemic cov teeb meem nyob rau hauv cov neeg kev txom nyem los ntawm kab mob plawv thiab leeg nrog txoj kev pheej hmoo ntawm kev loj hlob: kev haus luam yeeb, haus dej cawv, muaj hnub nyoog ntau dua 50 xyoo, muaj mob muaj keeb, muaj ntshav siab, qib C-reactive protein ntau.

Cov tshuaj siv dav hauv kev siv tshuaj rau kev kho mob thiab rau kev tiv thaiv ntawm cov teeb meem ntawm cov hlab plawv. Tam sim no, Rosart tshuaj thiab cov tshuaj analogues tau raug kho rau feem ntau cov neeg mob ntshav siab nrog cov roj uas tsis tau kho kom zoo.

Kev noj haus thiab kev kho mob statin

Kev noj zaub mov zoo thaum lub sijhawm kho hypercholesterolemia yuav tsum tsis txhob muaj cov calories ntau nyob rau hauv - los ntawm 2400 txog 2700 calories tauj ib hnub. Ib qho ntxiv, cov khoom noj yuav tsum tsis txhob muaj:

• rog, haus luam yeeb tais diav, nrog rau cov zaub mov npaj ntawm cov grill thiab grill,
• cov kaus poom zaub mov uas muaj roj thiab roj ntau,
• qe - ntau tshaj peb daim tauj ib lim tiam,
• butter
• muaj roj ntau thiab cov ntses,
• hnyuv ntxwm, sausages, jelly, aspic,
• tag nrho cov mis ntau dua 2.5%, qaub cream, qab zib,
• nqaij npuas kib, nqaij npuas kib

• rog yaug,
• Confectionery nrog butter cream thiab creamy fillers.

Kev noj haus uas muaj cov roj (cholesterol) siab yuav tsum muaj cov zaub thiab txiv hmab txiv ntoo ntau. Cov zaub yuav tsum noj cov zaub nyoos tshiab hauv zaub xam lav, noj zaub thiab ci, zaub ntsuab ntxiv. Zaub nyoos, compotes yog npaj los ntawm txiv hmab txiv ntoo, ci nrog zib ntab. Raws li cov khoom noj ntawm protein rau ua noj, tshiab lub tsev muaj roj tsawg cheese thiab cov nqaij ntshiv (nqaij qaib, nqaij tawv, luav, qaib ntxhw) yog siv. Kev siv cov khoom cog qoob loo yog kev txhawb nqa.

Cov khoom noj txhua hnub yuav tsum tau muab faib ua ntau pluas mov - ntawm plaub mus rau rau. Cov tais diav ntim tau ua ib daim ntawv sov. Koj yuav tsum tau haus tsawg kawg ib thiab ib nrab litres dej nyob rau hauv ib hnub, ntxiv rau kua zaub, kua txiv, tshuaj yej.

Rosart kev cai teem caij

Nyob rau hauv cov xwm txheej uas kev siv kev noj haus tsis muab qhov txiaj ntsig uas xav tau thiab cov cholesterol nyob hauv qib siab, Rosart ntsiav tshuaj lossis lwm yam statins yog tshuaj. Cov ntsiav tshuaj tuaj yeem qaug cawv txhua lub sijhawm ntawm hnub, tsis hais lub sijhawm noj mov. Cov tshuaj yuav tsum tau muab ntxuav nrog lub qhov dej dawb. Kev siv tshuaj hypolipidemic qhia saum toj no yuav tsum tau ua thaum kho cov tshuaj statin. Qhov ntau thiab tsawg ntawm cov tshuaj hauv txhua kis tau xaiv ib tus zuj zus. Raws li txoj cai, Rosart kho pib nrog qhov tsawg kawg nkaus ntawm 5 mg. Qee zaum, nrog cov lej hauv qib siab hauv cov roj cholesterol, cov pib yuav yog 10 mg ntawm cov tshuaj. Ob peb lub lis piam tom qab pib kho, nrog kev kho mob tsis ua haujlwm, cov koob tshuaj nce mus rau 20 mg. Kev siv cov tshuaj uas txo qis roj yeej txhaws ntev, qee zaum thaum lub sijhawm koj lub neej.

Noj ntau dhau

Cov tsos mob ntawm kev noj tshuaj tshaj ntawm rosuvastatin tsis tau muaj pov thawj. Qhov hno ntawm ob peb koob tshuaj txhua hnub ntawm Rosart tsis cuam tshuam rau qhov pharmacokinetics.

Kev Kho Mob: kev teem caij kho mob yam mob. Tswj kev ua si ntawm creatine phosphokinase (CPK) thiab kab mob siab yuav tsum ua kom ntseeg tau. Yog tias tsim nyog, kev ntsuas raug coj los tswj txoj haujlwm ntawm cov kabmob thiab cov tshuab.

Qhov ua tau zoo ntawm hemodialysis yog qhov tsis zoo.

Cov lus qhia tshwj xeeb

Txoj kev pheej hmoo ntawm kev tsim mob myopathy, suav nrog rhabdomyolysis tau nce ntxiv thaum noj rosuvastatin nrog cov tshuaj hauv qab no: cyclosporine, HIV tiv thaiv kab mob tiv thaiv, nrog rau kev sib xyaw ntawm ritonavir nrog atazanavir, tipranavir thiab / lossis lopinavir. Yog li, kev txiav txim siab yuav tsum tau muab rau kev teem sijhawm kho lwm txoj kev, thiab yog tias tsim nyog, kev siv cov nyiaj no - kev kho nrog rosuvastatin yuav tsum tau txiav tawm ib ntus.

Thaum siv Rosart ntawm ib koob ntawm 40 mg, nws yog ib qho tsim nyog yuav tau soj ntsuam cov ntsuas ntawm lub raum ua haujlwm tas li.

Thaum txiav txim siab kev ua ntawm CPK, nws yog qhov yuav tsum tau ua kom tsis txhob muaj qhov xwm txheej uas tuaj yeem ua txhaum kev ntseeg siab ntawm cov txiaj ntsig, suav nrog kev ua haujlwm ntawm lub cev. Cov neeg mob uas muaj qhov nce siab hauv thawj cov dej num ntawm CPK yuav tsum rov kuaj dua tom qab 5-7 hnub. Nyob rau hauv rooj plaub ntawm kev pom zoo ntawm tsib-npaug dhau ntawm cov cai ntawm KFK kev ua si, kev siv cov tshuaj yog contraindicated.

Kev saib xyuas tshwj xeeb yuav tsum tau saib xyuas thaum sau ntawv Rosart rau cov neeg mob uas muaj kev pheej hmoo rau kev txhim kho myopathy lossis rhabdomyolysis, ua tib zoo ntsuas kev ntsuas ntawm cov txiaj ntsig tau txais thiab cov kev pheej hmoo txaus los ntawm kev kho. Soj ntsuam kev kho mob yuav tsum tau muab rau pawg no ntawm cov neeg mob thoob plaws hauv kev kho mob. Koj tsis tuaj yeem pib noj cov ntsiav tshuaj nrog kev pib ua haujlwm ntawm CPK 5 zaug siab dua li cov kev txwv sab sauv.

Tus kws kho mob yuav tsum qhia rau tus neeg mob txog qhov yuav tshwm sim ntawm cov leeg mob, kub cev, kub cev, mob leeg tsis muaj zog lossis mob plab thaum kho, thiab yuav tsum nrhiav kev kho mob tam sim ntawd. Nrog kev nce ntxiv hauv KFK cov haujlwm lossis cov tsos mob hauv lub cev, kev kho yuav tsum tsis ua ntxiv. Nrog rau ploj ntawm cov tsos mob thiab rov qab ua dua ntawm KFK qhov taw qhia kev ua haujlwm, nws yog qhov ua tau kom rov ua tshuaj rau hauv cov tshuaj me dua.

1-2 zaug hauv ib hlis, cov lipid profile yuav tsum tau saib xyuas thiab cov koob tshuaj Rosart hloov kho raws li nws cov txiaj ntsig.

Nrog keeb kwm ntawm daim siab mob siab thiab hauv cov neeg mob uas quav cawv, nws tau pom zoo tias ua ntej pib kev kho thiab tom qab peb lub hlis ntawm kev siv tshuaj, kab mob siab ua haujlwm tau txiav txim siab. Yog tias qhov kev ua si ntawm hepatic enzymes hauv cov ntshav cov ntshav yog 3 zaug siab dua li cov kev txwv sab sauv ntawm qhov ib txwm, koj yuav tsum txo qhov koob tshuaj lossis tsum tsis noj Rosart.

Vim tias kev sib xyaw ntawm HIV tiv thaiv cov tshuaj tiv thaiv kab mob nrog ritonavir ua rau muaj kev nce ntxiv ntawm cov kab mob rosuvastatin, qhov kev txo qis hauv cov ntshav lipid yuav tsum ua tib zoo ntsuas, qhov yuav tsum tau nce ntxiv ntawm cov tshuaj loog ntawm rosuvastatin nyob rau hauv cov ntshav ntshav yuav tsum tau suav nrog ob qho tib si thaum pib ntawm kev kho mob thiab thaum lub sijhawm nce ntxiv ntawm cov tshuaj,

Yuav tsum tshem tawm Rosart yog tias muaj kev ua haujlwm tsis txaus ntseeg los ntawm kev mob ntsws, uas yuav ua rau siav, ua pa hnoos, tsis muaj zog, poob ceeb thawj, thiab kub ib ce.

Cev xeeb tub thiab lactation

Raws li cov lus qhia, Rosart yog contraindicated nyob rau hauv lub sijhawm ntawm tus poj niam cev xeeb tub thiab pub niam mis.

Teem tseg cov tshuaj rau cov poj niam uas muaj hnub nyoog yug me nyuam yuav tsum tau ua tsuas yog thaum lawv siv txoj kev tiv thaiv kom ntseeg tau.

Tus neeg mob yuav tsum tau txais kev ceeb toom txog cov kev pheej hmoo rau tus me nyuam hauv plab thaum muaj kev xeeb tub thaum lub sijhawm kho.

Yog tias nws yuav tsum tau coj Rosart thaum lactation, pub mis rau menyuam yuav tsum nres.

Nrog lub raum tsis ua haujlwm

Kev siv Rosart yog contraindicated nyob rau hauv ib qho ntawm koob tshuaj rau kev mob raum tsis zoo nrog CC tsawg dua 30 ml / min, ntawm ib koob ntawm 40 mg - nrog CC los ntawm 30 txog 60 ml / min.

Nrog rau cov qog ua lub ntsej muag lossis lub qog ua kom lub raum tsis ua haujlwm, tsis tas yuav hloov kho qhov tshuaj, kev txhaj tshuaj thawj zaug nrog CC tsawg dua 60 ml / min yuav tsum yog 5 mg.

Nrog lub siab ua haujlwm tsis zoo

Hloov cov koob tshuaj rosuvastatin tsis tas yuav ua rau daim siab ua haujlwm ntawm 7 cov ntsiab lus lossis qis dua ntawm Child-Pugh nplai, nrog 8 thiab 9 cov ntsiab lus ntawm Child-Pugh nplai, kev teem caij yuav tsum tau ua tom qab ntsuas ua ntej ntawm kev ua haujlwm ntawm lub raum.

Cov kev paub dhau los nrog Rosart hauv daim siab ua haujlwm siab tshaj 9 cov ntsiab lus ntawm Child-Pugh nplai tsis muaj.

Yeeb tshuaj sib cuam tshuam

Nrog kev siv tib lub Rosart:

• cov tshuaj uas inhibit thauj cov protein, cov substrate ntawm uas yog rosuvastatin, ua rau muaj kev pheej hmoo ntawm kev txhim kho myopathy,
• cyclosporine ua rau muaj kev cuam tshuam tseem ceeb hauv cov nyhuv ntawm rosuvastatin, nce nws qhov siab tshaj plaws hauv cov ntshav ntshav los ntawm 11 zaug,
• erythromycin tsub kom ntau C_max los ntawm 30% thiab txo qis hauv AUC ntawm rosuvastatin los ntawm 20%,
• warfarin thiab lwm qhov kev tiv thaiv kabmob tsis txaus ntseeg tuaj yeem ua rau MHO hloov pauv (qhov hloov pauv thoob ntiaj teb uas tau siv los txiav txim qhov ntsuas ntawm cov ntshav coagulation system): thaum pib siv thiab nrog qhov nce ntawm rosuvastatin, kev nce hauv MHO, thiab thaum koj tso tseg lossis txo qhov koob tshuaj rosuvastatin, qhov txo qis hauv INR, yog li kev soj ntsuam pom zoo. MHO
• lipid-txo cov tshuaj, suav nrog gemfibrozil, ua rau muaj kev nce ntxiv hauv AUC thiab C_max 2 zaug rosuvastatin,
• cov tshuaj tiv thaiv kab mob uas muaj txhuas thiab magnesium hydroxide txo cov ntshav plasma concentration ntawm cov tshuaj los ntawm 2 zaug,
• qhov ncauj tshuaj tiv thaiv nce AUC ntawm ethinyl estradiol los ntawm 26% thiab norgestrel los ntawm 34%,
• fluconazole, ketoconazole thiab lwm yam tshuaj uas yog cov tshuaj tiv thaiv ntawm isoenzymes CYP2A6, CYP3A4 thiab CYP2C9 tsis ua rau muaj kev cuam tshuam loj hauv chaw kho mob.
• ezetimibe (ntawm koob tshuaj 10 mg) hauv cov neeg mob hypercholesterolemia nce AUC ntawm rosuvastatin (ntawm koob tshuaj 10 mg) los ntawm 1.2 npaug, qhov kev txhim kho ntawm cov xwm txheej tsis zoo yog tau,
• HIV protease inhibitors tuaj yeem ua rau kom muaj qhov nce ntawm rosuvastatin,
• Digoxin tsis ua rau muaj kev sib txuam hauv tsev kho mob loj.

Thaum lub sijhawm siv cov rosuvastatin, koj yuav tsum sab laj nrog kws kho mob yog tias nws yuav tsum sib xyaw nws nrog lwm cov tshuaj.

Rosart's analogs yog: Akorta, Actalipid, Vasilip, Lipostat, Mertenil, Medostatin, Zokor, Simvakol, Rosuvastatin, Krestor, Rosucard, Rosistark, Rosulip, Torvazin, Tevastor, Kholetar.

Rosart Xyuas

Kev txheeb xyuas txog Rosarte feem ntau zoo. Cov neeg mob qhia tau hais tias qhov kev kho mob sai sai, hais tias cov roj (cholesterol) ua rau zoo thaum pib ntsiav tshuaj, tab sis kev siv cov tshuaj yog ib qho tsim nyog yuav tsum ua kom nws cov nqi tsis pub dhau.

Qee tus neeg mob tau ceeb toom tias muaj qhov tsis zoo tshwm sim ua pob khaus thiab tawm pob, txo cov ntshav siab, qhov tshwm ntawm mob taub hau thiab mob plab yog ua tau. Tab sis feem ntau, nws tau sau tseg tias Rosart muab cov kev mob tshwm sim tsawg kawg hauv kev sib piv nrog lwm cov tshuaj zoo sib xws. Rau ntau, tus nqi ntawm cov tshuaj yog heev.

Rosart tus nqi hauv cov khw muag tshuaj

Rosart nqi nyob ntawm ntau npaum:

• Rosart 5 mg rau ib pob ntawm 30 ntsiav tshuaj - los ntawm 400 rubles, 90 ntsiav tshuaj - los ntawm 1009 rubles,
• Rosart 10 mg rau ib pob ntawm 30 ntsiav tshuaj - los ntawm 569 rubles, 90 ntsiav tshuaj - los ntawm 1297 rubles,
• Rosart 20 mg rau pob ntawm 30 ntsiav tshuaj - los ntawm 754 rubles, 90 ntsiav tshuaj - los ntawm 1954 rubles,
• Rosart 40 mg rau pob ntawm 30 ntsiav tshuaj - los ntawm 1038 rubles, 90 ntsiav tshuaj - los ntawm 2580 rubles.

Cov hau kev thov qauv

Kev piav qhia txog kev siv tshuaj los ntawm lub siab cov roj (index) cov roj (cholesterol) siab nrog lub ntsiab lus tseem ceeb ntawm rosuvastatin - Rosart:

• Kev pib ntawm kev siv tshuaj kho mob nrog Rosart tshuaj pib nrog kev noj zaub mov zoo roj, uas ua tiav cov kev kawm tag nrho ntawm kev kho nrog statins,
• Tus kws kho mob uas tuaj koom yuav qhia yuav ua li cas noj Rosart, nrog rau cov koob tshuaj yog tus kheej xaiv los ntawm tus kws kho mob raws li kev ntsuas ntawm biochemistry nrog lipid spectrum (lipograms),
• Cov ntsiav tshuaj Rosart yuav tsum haus tag nrho thiab tsis zom, thiab ntxuav nrog dej kom ntau. Tsis tas yuav khi cov tshuaj rau ib pluas noj, koj tsuas yog xav saib lub sijhawm ntawm kev noj mov txhua hnub. Nws raug nquahu kom coj Rosart nyob rau yav tsaus ntuj ua ntej yuav mus pw, thiab qhov no yog vim los ntawm bioprocesses hauv tib neeg lub cev, thiab txij li lub sijhawm los ua ke ua ke ntawm cov roj cholesterol los ntawm lub siab ua haujlwm,
• Rosart thawj koob ntawm 5.0 lossis 10.0 milligrams, ib hnub ib zaug,
• Tsuas yog tus kws kho mob uas tuaj koom tuaj yeem ntxiv qhov ntau npaum lossis hloov cov tshuaj nrog cov tshuaj analogue, tab sis tsis ntxov dua tom qab ib hlis ntawm kev kho Rosart. Kev nce ntxiv tsuas yog tshwm sim raws li kev tshwm sim ntawm biochemical kuaj thiab thaum txhaj tsawg kawg tsis muaj txiaj ntsig,
• Qhov ntau kawg noj ib hnub twg - 40.0 milligrams, raug kho rau cov neeg mob uas muaj kev pheej hmoo siab los ntawm kev ua rau lub plawv mob lossis cov kab mob ntawm cov ntshav ncig, tab sis tsuas yog yog tias Rosart cov tshuaj noj nrog qhov tshuaj 20.0 milligrams tsis coj ua rau txo qis hauv qhov ntsuas cov roj (nrog hypercholesterolemia ntawm kev tshuaj ntsuam genetic lossis non-family-etiology). Kev kho mob nrog tshuaj ntawm Rosart hauv 40.0 milligrams tsuas yog nqa tawm hauv tsev kho mob raws li kev saib xyuas tas li los ntawm kws kho mob,
• Qhov ntau tshaj yog muab rau cov neeg mob uas muaj mob hnyav ntawm lub cev atherosclerosis,
• Nrog rau kev kho nrog qhov ntau npaum li 10.0 milligrams, saib xyuas tus roj (cholesterol) thiab ntsuas qhov qis tau - tom qab 14 hnub ua haujlwm,
• Nrog cov kawm tiav ntawm kev loj hlob ntawm cov kab mob pathologies ntawm lub raum hloov tshiab, tsis tas yuav muaj kev kho kom haum rau koob tshuaj, thiab cov koob tshuaj tsis raug hloov kho thaum muaj hnub nyoog nce - laus dua 70 xyoo, tab sis kev kho yuav tsum pib nrog 5.0 milligrams ib hnub,
• Kev noj tshuaj ntau kawg nkaus ntawm 40.0 milligrams ib hnub twg, ib txwm saib xyuas cov yeeb yaj kiab creatine phosphokinase index,
• Yog hais tias tus neeg mob muaj keeb kwm mob myopathy, ces kev kho mob yuav tsum tau nqa nrog ib koob tshuaj Rosart ntawm 5.0 milligrams,
• Cov neeg mob uas muaj cov kab mob siab ntawm lub siab ua haujlwm rau Child-Pugh nplai, nce txog 7.0 cov ntsiab lus, ua ntej kev teem caij mus ua qhov kev kuaj mob kom zoo thiab tsis txhob sau ntawv ntau dua 5,0 milligrams ib hnub.

Qhov siab dua ntau dua ntawm cov tshuaj nquag hauv cov ntsiav tshuaj, ntau qhov cuam tshuam tsis zoo rau lub cev los ntawm nws txoj kev tswj hwm.

Cov lus qhia rau kev teem caij

Rosart yog kho rau kev kho mob ntawm cov pathologies:

• Tus thawj mob heterozygous tsis muaj keeb thiab tsev neeg hom hypercholesterolemia (hom 2A raws li Fredrickson) ntxiv rau kev noj zaub mov roj, nrog rau cov tsis muaj caj ces hypercholesterolemia, nrog rau kev noj zaub mov zoo, ua kom muaj kev ntxhov siab rau lub cev, nrog rau kev kho mob rog,
• Nrog homozygous hom hypercholesterolemia hauv kev sib xyaw nrog kev noj haus, yog tias kev noj zaub mov ib leeg tsis pab txo qis cov roj (cholesterol),
• Hom tshuaj hyperlipidemia (2B yam raws li Fredrickson), nrog cov khoom noj muaj roj cholesterol,
• Lub pathology ntawm dysbetalipoproteinemia (hom 3 raws li Fredrickson), ua ke nrog zaub mov noj,
• Tsev neeg etiology ntawm hypertriglyceridemia (Fredrickson yam 4) yog qhov tseem ceeb ntxiv rau cov roj (cholesterol),
• Txhawm rau nres qhov ua tau mob ntawm cov kab mob atherosclerosis nrog rau kev noj zaub mov zoo, kev ua kom lub cev, nrog rau poob phaus.

Thawj qhov kev tiv thaiv ntawm Rosart tshuaj yog nqa tawm nrog cov pathologies:

• Nrog hom arterial ntawm revascularization,
• Mob ischemia,
• Myocardial infarction thiab mob hlwb tawg,
• Nrog lub hnub nyoog ntawm tus txiv neej lub cev 50 xyoo thiab 55 xyoo hauv cov poj niam,
• Kev ua haujlwm siab ntawm C protein
• Nrog ntshav siab
• Nrog rau kev txo HDL cov roj cholesterol ntu ntsuas,
• Nrog kev tso tshuaj nicotine thiab cawv ntxiv.

Thaum Twg Kuv Siv Tsis Tau Rosart?

Cov lus qhia rau kev siv Rosart suav nrog ib qho kev piav qhia txog ntawm cov tshuaj uas tsis tuaj yeem siv tshuaj. Rosart nyob rau hauv cov tshuaj ntawm 5, 10, 20 mg yog contraindicated nyob rau hauv cov mob hauv qab no:

1. Cov ntxhais hluas uas tsis siv txoj hauv kev los tiv thaiv kev xeeb tub.
2. Lub siab ua mob rau daim siab.
3. Kom siab li ntawm hepatic transaminases (enzymes) uas tsis paub keeb kwm.
4. Kab mob rau lub raum, tus yam ntxwv cuam tshuam tsis zoo ntawm kev ua haujlwm.
5. Qee hom teeb meem ntawm kev zom zaub mov tsis txaus.
6. Cov menyuam hnub nyoog qis dua 18 xyoo.
7. Cov txheej txheem myopathic.
8. Lub sijhawm kho nrog cyclosporine.
9. Lub caij nyoog ntawm kev xeeb tub thiab kev pub niam mis.

Rosart ntsiav tshuaj muaj 40 mg ntawm Rosuvastatin kuj tseem sib xyaw cov kabmob thiab cov kev mob hauv nruab nrog sab saum toj. Ntxiv rau, Rosart 40 mg tsis tuaj yeem siv nrog:

1. Kev kho mob nrog cov tshuaj cuam tshuam nrog fibrates.
2. Mob qog (hypothyroidism).
3. Cawv kev quav cawv.
4. Myopathies yav dhau los tau los ntawm kev siv statins thiab fibrates.
5. Cov xwm txheej uas tuaj yeem ua rau kom ntshav nce ntxiv ntawm rosuvastatin.
6. Burdened tus kab mob rau cov kab mob ntawm cov leeg ua ke.
7. Muaj feem nrog rau haiv neeg Mongoloid.

Cev xeeb tub thiab pub mis rau menyuam noj

Txij li Rosart muaj peev xwm hla dhau qhov teeb meem placental, kev siv cov tshuaj thaum lub caij cev xeeb tub yog contraindicated.

Yog tias cev xeeb tub tshwm sim thaum lub sijhawm ua haujlwm ntawm Rosart, kev kho mob statin yuav tsum nres tam sim ntawd.

Thaum sau tshuaj Rosuvastatin rau cov poj niam ntawm kev yug menyuam uas tsis siv txoj hauv kev tiv thaiv kom muaj txiaj ntsig thiab muaj kev pheej hmoo siab ntawm cev xeeb tub, nws yog qhov yuav tsum tau piav qhia txog qhov ua tsis xav tau ntawm Rosuvastatin tshuaj rau ntawm tus menyuam hauv plab. Lub peev xwm ntawm Rosuvastatin kom dhau mus rau hauv niam cov kua mis tseem tsis tau pom tseeb, tab sis tsis tau muab cais. Yog li ntawd, Rosart tsis tau siv thaum pub mis.

Siv Rosart nrog ceev faj

Ntxiv rau, muaj cov mob uas Rosart siv, tab sis nrog ceev faj. Cov ntsiav tshuaj uas muaj 5, 10 thiab 20 mg ntawm Rosuvastatin tau sau tseg nrog ceev faj hauv:

1. Txoj kev pheej hmoo ntawm myopathy.
2. Cov sawv cev ntawm haiv neeg Moob.
3. Hla 70 xyoo lawm.
4. Kev Hypothyroidism
5. Cov kab mob tsis haum rau kev tsim cov txheej txheem myopathic.
6. Lub xub ntiag ntawm cov xwm txheej uas qhov ntsuas ntawm Rosuvastatin hauv cov ntshav ntshav tuaj yeem nce ntxiv.

Thaum xaiv Rosart, ib qho yuav tsum ua tib zoo xav txog qhov kev tiv thaiv uas twb muaj lawm kom thiaj li tiv thaiv kev txhim kho ntawm qhov tsis xav tau los ntawm cov kabmob thiab cov kab ke. Cov kev mob tshwm sim yog cov yam ntxwv ntawm txhua yam statins thiab tshuaj muaj rosuvastatin tsis muaj qhov tshwj xeeb.

Kev phiv tshuaj

• Lub cev tsis muaj zog thiab lub siab: mob taub hau, ntxhov siab, pw tsaug zog, tsis meej tshuaj, kiv taub hau, mob plab, kev txhim kho asthenic syndrome.

• Kev zom plab system: cem quav, nquag tso quav xoob, mob plab, duav, xeev siab, kub siab, mob ntawm tus txiav, kab mob siab.
• Metabolism: mob ntshav qab zib.
• Kab mob ntsws: ua pa los ntswg, pharyngitis, mob ntsws o, hnoos, mob ntsws, ua tsis taus pa.
• Cov leeg cev: myalgia (mob leeg), mob leeg nqaij, mob pob qij txha thiab mob nraub qaum, mob pob txha.
• Kev ua xua tuaj yeem tshwm sim nrog daim tawv nqaij ua pob, ua xua thiab o ntawm lub ntsej muag thiab caj dab, kev txhim kho anaphylaxis.
• Lwm qhov tsis xav tau.

Raws li txoj cai, qhov pom ntawm qhov tsis tsim nyog cuam tshuam yog ncaj qha ntsig txog qhov ntau ntawm cov tshuaj. Feem ntau nrog kev hloov kho koob tshuaj, cov tsos mob poob qis lossis ploj tag nrho.

Txawm li cas los xij, nrog kev txhim kho cov cim ntawm myopathy thiab kev fab tshuaj tsis haum, koj yuav tsum tam sim ntawd tsis txhob siv Rosart thiab nrhiav kev pab kho mob.

Tus kws kho mob yuav sau ntawv yuav cov txheej txheem thiab tshuaj uas txhawm rau tshem tawm qhov tsis xav tawm thiab xaiv cov tshuaj hloov.

Analogues ntawm cov tshuaj

Hauv kev lag luam tshuaj Lavxias muaj ntau cov tshuaj uas muaj cov rosuvastatin. Rosart cov lus piv txwv yog tsim los ntawm ob lub tuam txhab Lavxias thiab txawv teb chaws. Cov tshuaj yuav nrov heev: Rosucard, Rosulip, Rosuvastain-SZ, Roxer, Rosufast, Rustor, Rosustark, Tevastor, Mertenil. Tag nrho cov tshuaj no cov luam tawm ua qauv - generics. Tus thawj cov tshuaj muaj Rosuvastatin yog Krestor, tsim nyob hauv UK los ntawm Astra Zeneca. Tus nqi ntawm cov tshuaj uas muaj cov rosuvastatin yog qhov txawv thiab nyob ntawm tus neeg tsim khoom lag luam tus nqi, qhov ntau thiab ntau npaum li cas ntawm cov tshuaj hauv pob.

Thaum xaiv cov tshuaj kom txo qis cov roj cholesterol, koj yuav tsum tau ua kev paub, ua ntej txhua yam, los ntawm cov lus pom zoo ntawm koj tus kws kho mob.

Nws yog nruj me ntsis txwv tsis pub sau tshuaj rau statin kho koj tus kheej!

Tsuas yog tus kws kho mob tuaj yeem xaiv cov tshuaj kom raug thiab nws ntau npaum li cas, coj mus rau hauv tus lej ntsuas thiab contraindications. Nws yog qhov tseem ceeb uas koj qhia rau koj tus kws kho mob ntawm txhua yam tshuaj koj noj kom tsis txhob muaj kev sib cuam tshuam ntawm kev sib txuam pharmacological.

Cov roj hauv cov tshuaj roj ntshav Rosart: cov tshuaj xyuas thiab qhia txog kev siv

• Stabilizes qib qab zib kom ntev
• Rov kho cov tshuaj insulin pancreatic

Ib qho ntawm cov tseem ceeb thiab tseem ceeb tshaj plaws rau tib neeg lub cev yog roj (cholesterol). Nws yog ib qho tseem ceeb heev uas nws qhov ntsuas tau ua raws li tus txheej txheem, txij li lub cev tsis muaj peev xwm lossis them nyiaj tshaj yuav muaj kev cuam tshuam tsis zoo rau kev noj qab haus huv. Kev nce hauv LDL hauv cov ntshav pab txhawb qhov tshwm sim ntawm atherosclerosis, uas yog tus cwj pwm los ntawm cov kev hloov pauv ntawm kev luag tus kheej ntawm cov hlab ntsha thiab qhov txo qis hauv lawv qhov kev ywj pheej.

Tam sim no, lub hauv paus rau kev tiv thaiv ntau yam kab mob ntawm cov hlab plawv yog cov tshuaj uas koom nrog kev tswj hwm cov roj ntsha hauv cov ntshav hauv tib neeg lub cev. Lawv nyob muaj ntau yam ncaj ncees. Ib qho zoo tshaj plaws, muaj txiaj ntsig zoo thiab muaj kev nyab xeeb zoo lipid-txo tshuaj yog Rosart.

Hais txog qhov ua tau zoo, Rosart ua txoj haujlwm ua rau cov pab pawg statins, ua tiav cov ntsuas ntawm "tsis zoo" (lipoproteins uas tsis muaj roj) thiab nce qib ntawm cov roj "zoo".

Rau statins, tshwj xeeb, Rosart, kev kho mob hauv qab no yog cov yam ntxwv:

• Nws inhibits qhov kev txiav txim ntawm cov enzymes uas koom nrog hauv kev sib txuas ntawm cov cholesterol hauv hepatocytes. Vim tias qhov no, txo qis cov ntshav roj hauv plasma yog qhov pom muaj,
• Pab txo LDL hauv cov neeg mob uas raug kev txom nyem los ntawm cov roj ntsha hypercholisterinemia. Qhov no yog cov cuab yeej tseem ceeb ntawm statins, vim tias cov kab mob no tsis kho nrog kev siv tshuaj ntawm lwm pab pawg tshuaj,
• Nws muaj cov txiaj ntsig zoo ntawm kev ua haujlwm ntawm cov hlab plawv, txo qhov kev pheej hmoo ntawm cov teeb meem hauv nws txoj haujlwm thiab cuam tshuam cov kab mob,
• Kev siv cov tshuaj tiv thaiv no ua rau txo qis cov roj (cholesterol) tag nrho los ntawm ntau dua 30%, thiab LDL - txog 50%,
• Muaj ntau HDL hauv ntshav,
• Nws tsis ntxias qhov ua rau pom ntawm neoplasms thiab tsis muaj kev cuam tshuam ntawm lub cev ua rau cov nqaij hauv lub cev.

Rosart Nqe

Qhov sib txawv ntawm tus nqi ntawm cov tshuaj Rosart tshuaj yog nyob ntawm cov ntsiab lus ntawm cov tshuaj nquag hauv lawv (mg) thiab cov ntsiav tshuaj lawv tus kheej hauv pob.

Tus nqi ntawm Rosart 10 milligrams ntawm 30 daim hauv ib pob yuav kwv yees li 509 rubles, tab sis tus nqi ntawm Rosart nrog tib cov ntsiab lus ntawm cov tshuaj nquag, tab sis 90 daim hauv ib pob yog ob zaug siab - txog 1190 rubles.

Rosart 20 mg 90 pieces rau ib pob raug nqi txog 1,500 rubles.

Koj tuaj yeem yuav cov tshuaj hauv cov khw muag tshuaj los ntawm cov tshuaj noj. Nws yuav tsum nco ntsoov tias ua ntej pib kev kho mob, koj yuav tsum mus ntsib tus kws kho mob tshwj xeeb, tau kuaj mob tag thiab ua lub neej noj qab haus huv kom ua tiav cov txiaj ntsig siab kawg.

Yuav ua li cas coj statins cov kws tshaj lij yuav qhia hauv cov yeeb yaj kiab hauv tsab xov xwm no.

• Stabilizes qib qab zib kom ntev
• Rov kho cov tshuaj insulin pancreatic

Kev cuam tshuam nrog lwm yam tshuaj

• Cov tshuaj tiv thaiv Antacid txo qhov kev xav ntawm Rosart hauv cov hlab ntshav li ntawm 35.0%,
• Thaum noj nrog Digoxin, muaj kev pheej hmoo ntawm kev txhim kho pathologies, myopathy thiab rhabdomyolysis,
• Tshuaj tua kab mob ntawm cov pawg erythromycin thiab clarithromycin, nce lub plasma qhov ntau ntawm cov tshuaj Rosart nyob rau hauv kev sib xyaw ua ke ntawm cov ntshav ntshav,
• Hauv kev kho ntawm cyclosporin. Qhov kev nkag siab ntawm rosuvastatin nce siab ntau dua 7 zaug,
• Thaum siv Rosart thiab inhibitors, qhov concentration ntawm rosuvastatin ntau zog, uas yog fraught nrog txoj kev txhim kho myopathy,
• Thaum kho nrog warfavir, nws yog ib qho tsim nyog los saib xyuas lub sijhawm prothrombin,
• Cov tshuaj niacin provokes qhov txaus ntshai ntawm rhabdomyolysis.

Cov lus pom zoo rau kev teem caij

Rosart tshuaj yog tshuaj tsuas yog los ntawm tus kws kho mob mus kawm raws li cov txiaj ntsig ntawm qhov ntsuas thiab kuaj kev kuaj pom.

Ua ntej pib txoj kev kho mob, txhua tus neeg mob yuav tsum qhia rau tus kws kho mob txog qhov tshwm sim tsis zoo uas yog siv tshuaj Rosart.

Kev qhia tshwj xeeb yuav tsum muab tso rau qhov ua tau ntawm qhov mob nqaij thiab kev txhim kho pathology myopathy:

• Lub sijhawm Rosart txoj kev kho nyob rau ntawm 20.0 thiab 40.0 milligrams ntawm cov khoom xyaw dhia, kev ua si ntawm creatine phosphokinase index nyob rau hauv cov ntshav ntshav tau soj ntsuam tas li, ntxiv rau kev ua haujlwm ntawm cov leeg nqaij thiab lub raum. Kev nce ntxiv hauv cov kev ua ntawm creatine phosphokinase yog qhov cim ntawm txoj kev loj hlob ntawm pathology myopathy hauv cov leeg nqaij. Kev kho yuav tsum nres, lossis cov muab tshuaj hloov mus rau qhov tsawg kawg nkaus,
• Nrog rau txhua qhov sib zog ntawm qhov mob hauv cov leeg pob txha los yog pob txha, tus neeg mob yuav tsum mus ntsib kws kho mob. Feem ntau los ntawm kev noj tshuaj Rosart, cov leeg tsis muaj zog tshwm sim, thiab autoantibodies tau tsim hauv lawv,
• Yog tias tus poj niam raug kuaj mob thaum cev xeeb tub thaum lub sijhawm Rosart kho nrog cov tshuaj, tom qab ntawd cov tshuaj yuav tsum tau muab tshem tawm sai, thiab tus poj niam cev xeeb tub yuav tsum kuaj xyuas, thiab tus me nyuam hauv plab yuav tsum tau kuaj
• Yog tias muaj kev noj tshuaj ntau dhau ntawm Rosart tshuaj tshwm sim, ces koj yuav tsum tau sab laj nrog kws kho mob sai. Tus kws kho mob yuav sau ntawv kho cov tsos mob kom zoo; hemodialysis yog tias muaj kev noj ntau dhau ntawm Rosart yuav tsis ua hauj lwm.

Cov qauv tshiab

Txawv tebchaws piv txwv

Xaus

Kev siv cov tshuaj Rosart los txo cov roj (cholesterol) kom qis dua tsuas yog tso cai tau nrog kev teem caij cov koob tshuaj nkaus xwb los ntawm tus kws kho mob tuaj koom. Hloov cov tshuaj rau koj tus kheej yog txwv.

Yog tias koj ua raws li txhua qhov kev pom zoo ntawm tus kws kho mob thiab ua raws li kev noj haus, ces koj tuaj yeem kho qhov txheej txheem ntawm txoj kev kho.

Txoj kev kho yog nqa nrog kev soj ntsuam tas li ntawm cov roj (cholesterol).

Vitaliy, 60 xyoo: Kuv tau coj Rosart tau yuav luag ib xyoos. Cov roj (cholesterol) yuav ua rau nws nyob li qub tom qab noj tshuaj rau ib hlis.

Tus kws kho mob pom zoo rau kuv kom siv cov tshuaj hauv qhov sib faib, vim tias kuv yuav tsum ua kom kuv cov roj (cholesterol) nyob li qub.

Ua ntej noj cov tshuaj, Kuv tau mus dhau los ntawm kev noj haus hypolipidemic, tab sis cov roj (cholesterol) tsis tau txo.

Tsuas yog nrog kev teem caij Rosart thiab kev noj haus, Kuv muaj peev xwm qis dua, thiab tam sim no ua rau kuv cov roj (cholesterol) nyob tsis zoo. Cov kev mob tshwm sim yog thaum pib ntawm txoj kev kho nyob rau hauv daim ntawv ntawm daim tawv nqaij ua pob thiab mob plab, tab sis tom qab 2 lub lis piam ntawm kev tswj hwm lawv dhau.

Hnub Valentine, 51 xyoo: Tus kws kho mob tau hais kom Rosart rau kuv ntxiv rau kev noj haus, vim kuv qhov hnyav dhau thiab cov roj (9.0 mmol / L).

Rau 3 lub hlis ntawm kev noj tshuaj thiab kev noj haus, Kuv tswj kom poob 12 phaus, thiab cov roj cholesterol poob rau 6.0 mmol / L.

Kuv txaus siab rau qhov tshwm sim, tab sis nws yog qhov yuav tsum tau mus txuas ntxiv kev kho mob nrog Rosart ntsiav tshuaj, kom txog rau thaum tsim khov kho kuv cov roj uas txhaws taus ntawm tus qauv. Kuv tsis xav tias muaj kev phiv los ntawm cov tshuaj thaum kho cov tshuaj.