Cov tshuaj muaj nyob rau hauv daim ntawv ntawm qhov kev daws teeb meem. Nws yog cov kua ntshiab ntshiab nrog lub zas daj ntsuab.

Ib qho concentrate tseem muag, uas yog siv los npaj cov tshuaj. Nws yog cov tshuaj ntshiab lossis daj-ntsuab.

Ciprinol 250 mg ntsiav tshuaj yog biconvex, muaj cov duab puag ncig, xim dawb, beveled sawv. Lawv tau npog los ntawm cov ntaub xev zaj duab xis, ntawm ib sab ntawm cov ntsiav tshuaj muaj qhov cim tsis yog thais.

Ciprinol ntsiav tshuaj 500 mg yog biconvex, muaj oval duab, dawb xim. Cov ntsiav tshuaj yog them nrog ib zaj duab xis membrane, ntawm ib sab muaj ib qho nqis siab.

Ciprinol 750 mg ntsiav tshuaj yog oval zoo li tus, muaj ib txheej dawb zaj duab xis, thiab muaj cov cim tsis qab ntawm ob sab ntawm cov ntsiav tshuaj.

Pharmacological kev txiav txim

Ciprinol (ciprofloxacin) muaj cov nyhuv tshuaj rau lub cev. Qhov no yog tiam thib ob monofluorinated fluoroquinolone. Nyob rau hauv nws cov cawv, topoisomerase II, ib qho enzyme uas txiav txim qhov kev rov ua dua thiab biosynthesis ntawm cov kab mob deoxyribonucleic acid, yog inhibited. Nws koom nrog txoj hauv kev ntawm kev faib khoom ntawm tes ntawm cov kab mob thiab hauv biosynthesis ntawm cov protein.

Ciprinol muaj cov nyhuv bactericidal, nws yog qhov zoo tshaj tawm tsam cov kab mob gram-tsis zoo. Yog li, cov tshuaj siv rau hauv kev kho mob ntawm cov kab mob los ntawm cov kab mob no.

Tsis tas li, ntau tus kab mob gram-zoo nkag siab Ciprinol: Staphylococcus spp., Streptococcus spp. Nws cuam tshuam ntau cov kab mob sib kis.

Kev ua tau zoo ntawm cov tshuaj tau sau tseg hauv kev kho mob kis kab mob cuam tshuam los ntawm Pseudomonas aeruginosa. Ciprinol yog qhov tawm tsam tus mob chlamydia, anaerobes, mycoplasmas. Cov nceb, kab mob, tiv thaiv kab mob tsuas yog ua rau pom cov kev tawm tsam ntawm cov tshuaj.

Pharmacodynamics thiab pharmacokinetics

Ciprinol nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj yog nqus sai, tau mus rau hauv lub plab zom mov. Nws txoj kev nqus nws tsis cuam tshuam los ntawm kev noj zaub mov, nws txoj kev noj qab haus huv tsis txo. Bioavailability yog 50-85%. Qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw hauv tus neeg mob cov ntshav pom tau kwv yees li 1-1.5 teev tom qab noj cov ntsiav tshuaj. Tom qab nqus, cov tshuaj nquag tau muab faib rau hauv cov ntaub so ntswg ntawm cov genitourinary thiab ua pa, hauv cov kua nqaij synovial, cov leeg, tawv nqaij, cov nqaij rog, hauv cov qaub ncaug, hnoos qeev, kua cerebrospinal. Nws kuj nkag mus rau hauv cov kab mob hlwb (macrophages, neutrophils), uas txiav txim siab nws cov hauj lwm zoo los kho cov kab mob sib kis uas cov kab mob nyob hauv ib cheeb tsam intracellularly.

Raws li qhov tshwm sim ntawm biotransformation tshwm sim hauv daim siab, cov tshuaj tiv thaiv tsis tau pib tshwm sim. Cov tshuaj no tawm hauv lub cev los ntawm lub raum, nrog rau kev ua haujlwm ntawm cov txheej txheem ntxiv (nrog quav, nrog kua tsib). Ib nrab-lub neej ntawm cov tshuaj los ntawm lub cev yog los ntawm 5 mus rau 9 teev. Yog li, rau kev kho kom zoo, nws txaus los noj cov tshuaj ob zaug ib hnub.

Tom qab Txoj kev lis ntshav ntawm txoj kev daws teeb meem ntawm Ciprinol, qhov siab tshaj plaws yog mus txog tom qab 1 teev. Nrog kev qhia txog kev ua haujlwm ntawm cov leeg txhawm rau faib tawm cov nqaij hauv lub cev, nyob rau hauv uas muaj qhov siab dua ntawm cov tshuaj nquag hauv sib piv nrog cov ntshav ntshav, yog sau tseg. Ciprofloxacin nkag mus rau hauv cov hnoos qeev tau zoo.

Hauv cov neeg muaj lub raum zoo li qub, ib nrab-lub neej ntawm cov tshuaj yog los ntawm 3 txog 5 teev. Hauv cov neeg mob uas mob raum tsis ua haujlwm, kev tshem tawm ib nrab-lub neej nce mus txog 12 teev.

Tom qab Txoj kev lis ntshav, cov tshuaj yog tawm los ntawm lub raum. Li ntawm 50-70% ntawm cov tshuaj yog tawm hauv qhov hloov pauv tsis tau, lwm 10% yog tawm hauv cov qauv metabolites, cov tshuav ntxiv - los ntawm cov hnyuv zom zaub mov. Nrog rau niam cov kua mis, qhov feem pua me me ntawm cov tshuaj tseem hle tau.

Kev Qhia Txog Ciprinol

Ciprinol yog tus kws kho mob thaum nws tsim nyog los kho cov mob uas tau ua rau muaj mob los ntawm cov kab mob me me nrog kev paub txog ciprofloxacin ntau dhau los, ntawm ib tus neeg muaj qee yam kab mob. Yog li ntawd, qhov ntsuas yuav tsum tau siv ntawm cov tshuaj yog li nram no:

tus mob ua pa:mob ntswsmob ntsws, cystic fibrosis, bronchiectasis, thiab lwm yam.
kis tus kab mob ENT: otitis media, mastoiditis, mob ntsws,
tso zis thiab mob rau lub raum: cystitis, txoj hlab zispyelonephritis,
cov kab mob sib kis ntawm cov qau, thiab lwm qhov ntawm lub plab: prostatitis, epididymitis, endometritis, mob chlamydia, salpingitis, thiab lwm yam.
cov kab mob sib kis hauv nruab nrog plab: cholecystitischolangitis, mob plab intraperitoneal rwj, raws plab, tsim vim muaj mob, thiab lwm yam,
kis tau ntawm daim tawv nqaij thiab cov nqaij mos: mob rwj, kub nyhiab thiab qhov txhab ntawm ib hom mob sib kis, phlegmon, abscesses,
mob musculoskeletal: mob caj dab txha caj qaum, osteomyelitis,
kev txhim kho ntawm sepsis, kis tau rau hauv cov neeg muaj kev tsis taus tiv thaiv kab mob,
kev tiv thaiv kev tiv thaiv los tiv thaiv kev txhim kho kev mob kis thaum phais mob thiab orthopedic kev ua haujlwm,
kev kho thiab kev tiv thaiv ntawm anthrax mob ntsws.

Cov Yuav Tsum Tau Ua

Ciprinol yuav tsum tsis txhob raug tshuaj rau cov kab mob thiab kev mob hauv qab no:

qib siab ntawm kev nkag siab zoo rau ciprofloxacin, lwm yam tshuaj uas yog pawg ntawm fluoroquinolones lossis rau lwm qhov sib xyaw ntawm cov tshuaj.
cev xeeb tub thiab lub sijhawm pub mis,
muaj hnub nyoog txog 18 xyoo (tshwj tsis yog kev kho mob ntawm cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa hauv cov menyuam yaus hnub nyoog 5 txog 17 xyoo uas muaj kev mob ntsws ntsws mob ntsws, tseem siv rau kev kho mob thiab tiv thaiv anthrax hauv menyuam yaus),
tsis txhob siv cov tshuaj tib lub sijhawm Tizanidine.

Ciprinol yog tshuaj nrog kev ceev faj rau cov neeg mob uas muaj mob hnyav atherosclerosis hlab ntsha hauv lub hlwb, cov ntshav tsis txaus hauv lub hlwb, ntxiv rau cov neeg kev txom nyem qaug dab peg, mob hlwb, raum lossis mob siab. Kev mob ntawm cov neeg laus uas tau txais kev kho mob nrog rau cov tshuaj, nrog rau cov neeg uas muaj qhov tsis txaus cov piam thaj-6-phosphate dehydrogenase, yuav tsum tau saib xyuas kom meej meej.

Sab sij huam

Lub plab zom mov: ib txoj ntawm dyspeptic tshwm sim, kev tsis nco qab, kab mob hepatonecrosis, kab mob siab, mob cholestatic daj ntseg, pseudomembranous mob plab.
Cov leeg hauv nruab nrab:mob taub hau, mob taub hau, theem siab ntawm kev nkees thiab ntxhov siab, tsaus muag, cramps, tshee tshee, ntxhov siab, nce ICP, kev nyuaj siab, tsis nco qab, tsis meej pem, lwm yam kev xav.
Hnov kabmob siab:tsis pom kev, tsis hnov tsw, hnov lus, tsis muaj pob.
Kev kho plawv: teeb meem plawv tachycardia, tso tawm cov ntshav siab, hla tawm ntawm cov ntshav.
Hematopoietic system: anemia, leukopenia, thrombocytopenia, granulocytopenia, thrombocytosis, leukocytosis.
Cov kab mob zis: crystalluria, hematuria, glomerulonephritis, polyuria, dysuria, albuminuria, los ntshav, nephritis, poob qis nitrogen excretory ua haujlwm ntawm lub raum.
Cov tsos mob ua xua: urticaria, khaus ntawm daim tawv nqaij, hlwv thiab los ntshav, pom ntshav tawm, tshuaj kub cev, edema, vasculitis, erythema nodosum, exanthema, thiab lwm yam.
Musculoskeletal system: mob caj dab, mob caj dab, mob rau caj dab, caj dab txhaws, leeg txha ntshav txhaws, leeg ntshav.
Lwm yam kev qhia paub: candidiasis, rhiab heev rau lub teeb, tawm hws, lub xeev ntawm kev ua kom tsis muaj zog.
Raws li kev ntsuas ntsuas: nce kev ua haujlwm ntawm hepatic transaminases thiab alkaline phosphatase, hypoprothrombinemia, hyperuricemia, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
Thaum ua txhaum, cov kev tawm tsam hauv zos yuav tshwm sim.

Cov lus qhia rau kev siv Ciprinol (txoj kev thiab qhov ntau npaum li cas)

Ob leeg tswj hwm kev siv tshuaj ntawm Ciprinol thiab Ciprinol 500 mg (hauv cov ntsiav tshuaj) yog tshuaj ob zaug ib hnub. Hauv cov ntawv sib kis me ntawm kev kis tus kab mob ntawm lub tso zis lossis mob ntsws, thiab zawv plab ib koob tshuaj ib zaug yog tshuaj tso cai 250 mg. Hauv cov qauv mob loj lossis nrog cov mob hnyav, tus neeg mob yuav tsum noj 500 lossis 750 mg ntawm cov tshuaj.

Cov kev qhia rau Ciprinol 500 mg muab qhia tias nrog gonorrhea cov tshuaj tau tshwm sim ntawm qhov tshuaj no ib zaug. Yog hais tias kev tswj hwm qhov dej ntawm lub cev, yuav tsum tau siv tus lej sai, yog li ntawm 200-400 mg. Yog tias tus neeg mob yuav kuaj pom tus mob gonorrhea, 100 mg ntawm Ciprinol yog ib zaug txhaj tshuaj ua ke. Txhawm rau txhawm rau tiv thaiv kev kis mob tom qab, kwv yees li 1 teev ua ntej pib kev phais mob, 200-400 mg ntawm Ciprinol muab rau tus neeg mob.

Yog tias tus neeg mob tau ua txhaum lub raum, ces cov tshuaj txhua hnub rau kev tswj hwm qhov ncauj yog txo ib nrab.

Koj yuav tsum haus cov ntsiav tshuaj ua ntej noj mov, nws yog ib qho tseem ceeb kom haus cov tshuaj nrog dej kom ntau.

Noj ntau dhau

Nrog rau kev siv tshuaj ntau dhau, ib qho kev qhia ntawm ntau tus tsos mob tuaj yeem sau tseg: kiv taub haumob taub hau, ntuav, xeev siab, raws plab. Thaum muaj mob hnyav tshaj, ua rau tsis nco qab, tshee tshee, nriaj, ua kom pom kev txhaws siab.

Kev kho mob zoo li qub yog nqa tawm, nws yog ib qho tseem ceeb kom ntseeg tau tias tus neeg mob tau txais cov kua dej txaus, thiab ntxuav lub plab. Laxatives, cov pa roj carbon activated tseem raug xaj.

Kev sib txuam

Yog tias kho thaum tib lub sijhawm Ciprinol thiab Didanosine, ces muaj kev txo qis hauv kev nqus ntawm ciprofloxacin.

Hauv qab ntawm ciprofloxacin, cov concentration nce thiab ib nrab lub neej ntawm theophylline thiab lwm cov xanthines tau nce.

Nrog rau cov kev kho mob nrog rau ciprofloxacin thiab cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, nrog rau cov tshuaj tiv thaiv tsis tseem ceeb, prothrombin Performance index poob qis.

Tej zaum kev txhim kho ntawm qaug dab peg thaum noj ciprofloxacin thiab NSAIDs.

Kev nqus cov ciprofloxacin tuaj yeem txo qis nrog kev kho mob nrog tib neeg nrog tshuaj tiv thaiv kab mob, tshuaj uas muaj txhuas, hlau, zinc, thiab ions magnesium. Nws yog ib qho tseem ceeb kom paub meej tias qhov nyob nruab nrab ntawm kev noj cov tshuaj no yog tsawg kawg 4 teev.

Yog tias ciprofloxacin thiab cyclosporin siv tau ib txhij, tom qab ntawd cov nyhuv nephrotoxic ntawm tom kawg tau txhim kho.

Metoclopramide activates qhov kev nqus ntawm ciprofloxacin. Raws li qhov tshwm sim, lub sijhawm uas ncav cuag nws qhov siab tshaj plasma txo qis.

Hauv kev kho mob ntawm ciprofloxacin thiab tshuaj uricosuric, kev tshem tawm ntawm ciprofloxacin qeeb qeeb thiab nws cov peev xwm hauv plasma nce ntxiv.

Nrog rau kev tswj hwm thooj txhij nrog rau lwm cov tshuaj uas muaj cov tshuaj tua kab mob, synergism feem ntau tau sau tseg.

Cov lus qhia tshwj xeeb

Cov tib neeg muaj kev qaug dab peg, qaug dab peg, mob ntshav thiab cov kab mob hauv lub hlwb, ciprofloxacin tuaj yeem tsuas kho nyob rau ntawm qhov muaj cov cim tseem ceeb.

Yog tias muaj mob raws plab pom thaum lub sij hawm kho, daim ntawv qhia hnyav yuav tsum tau cais tawm.pseudomembranous mob plabCov. Thaum paub tseeb tias kev kuaj mob no, nws yog ib qho tsim nyog yuav tsum tshem tawm sai sai ntawm cov tshuaj thiab kho tus neeg mob.

Yog tias mob leeg caj npab raug sau tseg, nrog rau thawj cov cim ntawm tendovaginitis, cov chav kawm ntawm kev kho mob tau raug ncua, raws li muaj cov mob ntawm cov leeg mob thiab mob txhaws thaum kho nrog fluoroquinolones.

Kev siv lub cev nyhav yuav tsum tsis txhob xyaum thaum kho ciprofloxacin.

Kev siv tshuaj rau niaj hnub noj yuav tsum tsis pub dhau, vim tias qhov pheej hmoo ntawm crystalluria yog nce ntxiv. Txhawm rau kom muaj qhov tso zis zoo li qub, nws yog ib qho tseem ceeb uas yuav tsum haus dej txaus thaum kho.

Thaum kho nrog cov tshuaj, cov hluav taws xob muaj zog UV hluav taws xob yuav tsum tsis raug tso cai.

Hauv cov neeg muaj ntshav qabzib-6-phosphate dehydrogenase tsis txaus, hemolytic anemia yuav tshwm sim nrog kev tswj hwm ntawm Ciprinol.

Thaum kho nrog cov tshuaj tua kab mob, ib qho yuav tsum ua tib zoo tsav tsheb thiab ua lwm yam haujlwm cuam tshuam nrog kev nce siab.

Analogs nrog cov nyhuv zoo sib xws yog cov tshuaj Tsiprovin, Cyprrosan, Ciprolon, Cypropane, Cyproquin, Tariferid, Syflox, Pheej, Kho dua, Oflomak, Norilet, Oflocide, Negaflox, Norfacin thiab lwm yam. Tag nrho cov qauv tshuaj no tsuas yog tso cai tom qab tus kws kho mob pom zoo. Nws yuav tsum tau nug koj tus kws kho mob txog cov tshuaj uas tsim nyog xaiv, nrog rau seb nws puas yog tshuaj tua kab mob lossis tsis yog.

Nrog tshuaj tua kab mob

Kev sib xyaw ntawm ciprinol nrog ceftazidime thiab azlocillin kho mob rau cov kab mob los ntawm Pseudomonas spp. Hauv kev kho mob ntawm kab mob streptococcal, kev sib xyaw nrog meslocillin, azlocillin, thiab lwm yam tshuaj tua kab mob beta-lactam raug tso cai. Hauv kev kho mob ntawm tus mob staph, cov tshuaj no ua ke nrog vancomycin thiab isoxazolepenicillins. Hauv kev kho kab mob anaerobic, kev sib xyaw nrog metronidazole thiab clindamycin raug tso cai.

Nrog cawv

Nws yog txwv tsis pub haus dej cawv thaum kho nrog Ciprinol.

Cov tshuaj tuaj yeem raug kho rau kev kho mob rau menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo tsuas yog tias txoj kev kho thiab prophylaxis ntawm anthrax yog qhov tsim nyog, nrog rau kev kho mob ntawm cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa hauv cov menyuam yaus mob ntsws ntsig.

Ciprofloxacin

Ciprofloxacin: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Ciprofloxacinum

ATX Code: S03AA07

Cov khoom xyaw nquag: Ciprofloxacin (Ciprofloxacinum)

Tus tsim khoom: PJSC Farmak, PJSC Technolog, OJSC Kyivmedpreparat (Ukraine), LLC Ozon, OJSC Veropharm, OJSC Synthesis (Russia), C.O. Tuam txhab Rompharm S.R.L. (Romania)

Qhia kho cov lus piav qhia thiab yees duab: 04/30/2018

Cov nqi hauv khw muag tshuaj: los ntawm 6 rubles.

Ciprofloxacin yog cov tshuaj tua kabmob uas muaj ntau qhov kev ua haujlwm ntawm cov kabmob kev ua haujlwm los ntawm cov pab pawg ntawm fluoroquinolones.

Kev tshuaj xyuas txog Ciprinol

Kev tshuaj xyuas tus neeg mob tau qhia tias nrog kev pab Ciprinol lawv tuaj yeem kov yeej txoj kev kis kab mob uas ua rau tus kabmob ploj. Txawm li cas los xij, muaj ntau qhov kev txheeb xyuas txog qhov kev tshwm sim ntawm cov kev mob tshwm sim thaum kho. Tshwj xeeb, dysbacteriosis, kab mob fungal, thiab qhov tsis zoo ntawm lub chaw kuaj ntshav suav tau hais tseg. Nws raug sau tseg tias qhov tshuaj tiv thaiv yuav tsum tau noj nyob rau lub sijhawm uas tus kws kho mob tau hais tseg.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj yog txiav txim los ntawm tus kws kho mob, nyob ntawm qhov mob hnyav, hom mob, tus mob lub cev, hnub nyoog (qis dua 18 lossis 60 xyoo), hnyav thiab lub raum ua haujlwm.

Kev ntsuas rau siv

Ib koob tshuaj / ib hnub rau cov neeg laus

Tas nrho lub sijhawm kho

(suav txog kev kho mob nrog cov ntaub ntawv ntawm niam txiv ciprofloxacin)

Kev nqus tau kab mob tsawg dua

Sab sauv ntawm kab mob ua pa

Exacerbation ntawm kev mob caj dab ntev

Ntev li mob otitis media

Malignant otitis sab nraud

Mob txeeb zig

Cov poj niam menopausal - ib zaug 500 mg

Mob cystitis, mob tsis yooj yim rau pyelonephritis

Tsawg kawg 10 hnub, nyob hauv qee kis (piv txwv, muaj kev mob tshwm sim) - txog 21 hnub

2-4 lub lis piam (mob)

4-6 lub lis piam (mob)

Chaw mos kis tau tus mob

Gonococcal mob rau txoj hlab zis thiab lub ncauj tsev menyuam

Ib koob tshuaj 500 mg

Orchoepididymitis thiab mob txha caj qaum ntawm cov plab hnyuv siab raum

Tsis pub tsawg tshaj 14 hnub

Mob plab hnyuv thiab mob rau sab hauv plab

Kev mob plab zawv los ntawm kev kis tus kab mob, suav nrog Shigella spp, tsuas yog Shigella dysenteriae hom I thiab kev kho mob zoo kawg nkaus ntawm cov neeg mob lub cev zawv plab heev

Zawv plab los ntawm Shigella dysenteriae hom I

Vibrio chlera raws plab

Gram-negative tso leeg mob plab

Cov tawv nqaij thiab cov nqaij mos kis tau tus mob

Sib koom tes thiab pob txha mob

Kev tiv thaiv thiab kho kab mob hauv cov neeg mob neutropenia. Pom zoo teem caij nrog lwm cov tshuaj

Kev kho mus txuas ntxiv kom txog rau thaum kawg ntawm lub sijhawm neutropenia.

Kev tiv thaiv kev kis mob tsis nco qab uas tshwm sim los ntawm Neisseria meningitides

Postexposure prophylaxis thiab kho mob ntawm anthrax. Txoj kev kho yuav tsum tau pib kho sai li sai tau tom qab xav tias yog tus mob.

60 hnub txij li kev paub tseeb

Rau cov neeg mob laus, cov koob tshuaj tau raug txo los ntawm 30%.

Cov neeg mob uas muaj lub siab ua haujlwm tsis txaus: koob tshuaj yuav tsis tas kho.

Cov neeg mob uas lub raum tsis zoo: lub koob tau hloov kho raws li rooj:

250-500 mg ib zaug txhua 24 teev

250-500 mg ib zaug txhua 24 teev tom qab lim ntshav

Sab sij huam

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: erythema multiforme thiab nodosum.

Los ntawm cov kab mob plawv: lub caij nyoog ntev ntawm QT ncua, ventricular arrhythmias (suav nrog pirouette hom), vasculitis, kub muag ceev, migraine, tsaus muag.

Los ntawm lub plab zom mov thiab lub siab: flatulence, tsis nco qab.

Los ntawm sab ntawm lub paj hlwb thiab paj hlwb: kev mob ntshav siab intracranial, insomnia, ntxhov siab, tshee, nyob rau hauv cov xwm txheej tsis tshua muaj, kev ntxhov siab ntawm lub siab tsis hnov tsw, tawm hws, kab ntsig thiab dysesthesia, kev tsis sib haum, tsis hnov qab, qaug dab peg, kev ntshai thiab tsis meej pem, npau suav phem, kev ntxhov siab, tsis meej, tsis hnov qab thiab hnov tsw pom kev tsis txaus ntseeg (diplopia, chromatopsia), tinnitus, hnov lus tsis txaus. Yog tias cov kev cuam tshuam no tshwm sim, tsum tam sim ntawd tsum tsis haus tshuaj thiab qhia tus kws kho mob uas koom nrog.

Los ntawm cov kab ke hemopoietic: thrombocytopenia, tsis tshua muaj tshwm sim - leukocytosis, thrombocytosis, hemolytic anemia, anemia, agranulocytosis, pancytopenia (tuag taus), mob hlwb pob txha (tuag taus).

Kev ua xua thiab immunopathological: tshuaj kub taub hau, nrog rau photosensitization, tsis tshua muaj bronchospasm, tsis tshua muaj qhov tsis nco qab ceeb, myalgia, Lyell's syndrome, interstitial nephritis, mob siab.

Musculoskeletal system: mob caj dab, mob nqaij nruj thiab mob plab. Tsis tshua muaj heev - cov leeg tsis muaj zog, leeg mob hlwb, mob leeg (feem ntau Achilles leeg), exacerbation ntawm cov tsos mob ntawm myasthenia gravis.

Mob ntsws plab hnyuv siab raum: txog siav ua pa (suav nrog rau tus mob hawb pob).

General mob: asthenia, kub taub hau, o, tawm hws (hyperhidrosis).

Cawv rau ntsuas ntsuas: hyperglycemia, kev hloov pauv hauv qhov kev txiav txim ntawm prothrombin, kev nce hauv amylase kev ua ub no.

Daim ntawv thov nta

Ua ntej pib txoj kev kho mob, sab laj nrog koj tus kws kho mob!

Yog tias mob raws plab thiab mob ntev dhau los thaum lub caij lossis tom qab kho tas, nrog kws kho mob tham tam sim ntawd.

Yog tias muaj mob ntawm nqaij pob txha, koj yuav tsum tsis txhob noj tshuaj thiab sab laj nrog kws kho mob.

Cawv rau ntawm kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog cov tshuab

Thaum kho, ib qho yuav tsum tsis txhob koom nrog kev ua haujlwm uas muaj kev phom sij uas xav tau kev saib xyuas ntxiv thiab ceev ntawm lub hlwb thiab lub cev kev hloov.

Kev tiv thaiv kev nyab xeeb

Mob atherosclerosis ntawm cov hlab ntsha hlwb, cov kab mob hlab ntsha tawg, mob hlwb, mob vwm, mob vwm, mob raum thiab lub siab ua haujlwm tsis zoo, ua kom lub hnub nyoog dhau los.

Lub siab tsis zooCov. Ciprofloxacin yuav tsum tau siv nrog kev ceev faj hauv kev sib xyaw nrog cov tshuaj uas txuas ntxiv QT ntu sij hawm (piv txwv, cov chav kawm I thiab III tshuaj tiv thaiv kab mob), lossis hauv cov neeg mob uas muaj kev pheej hmoo loj ntawm pirouette hom arrhythmias (piv txwv li, nrog paub txog kev ncua ntev ntawm QT luv, kho hypokalemia).

Musculoskeletal system.Ntawm thawj cov tsos mob ntawm leeg (mob o nyob rau hauv kev sib koom tes, mob), siv cov ciprofloxacin yuav tsum nres, kev ua haujlwm ntawm lub cev yuav tsum raug txiav txim siab, vim tias muaj kev pheej hmoo ntawm kev tawg ntawm cov leeg, thiab sab laj kws kho mob. Ciprofloxacin yuav tsum siv nrog kev ceev faj hauv cov neeg mob noj tshuaj steroids nrog keeb kwm ntawm cov leeg mob muaj feem nrog quinolones.

Ciprofloxacin txhim kho cov leeg tsis muaj zog hauv cov neeg mob uas myasthenia gravis.

Siv nrog ceev faj yog tias muaj keeb kwm ntawm mob hlab ntsha tawg, mob hlwb (kev nyuaj siab, mob hlwb), lub raum tsis ua haujlwm (tseem nrog daim siab tsis ua haujlwm). Hauv qee qhov xwm txheej tsawg, kev mob hlwb hauv lub siab los ntawm kev tua tus kheej. Hauv cov rooj plaub no, koj yuav tsum tam sim ntawd tsum tsis txhob noj ciprofloxacin thiab qhia koj tus kws kho mob.

Thaum noj ciprofloxacin, qhov kev tawm tsam qhov pom kev tsis haum xeeb tuaj yeem tshwm sim, yog li cov neeg mob yuav tsum tsis txhob kov cov hnub ncaj qha thiab UV teeb. Kev kho mob hauv qhov no yuav tsum tau txiav.

Kev ceev faj yuav tsum tau siv thaum siv ciprofloxacin thiab theophylline, methylxanthine, caffeine, duloxetine, clozapine, vim tias kev nce siab ntawm cov tshuaj no hauv cov ntshav tuaj yeem ua rau muaj kev phiv tshuaj tsis zoo.

Txhawm rau kom tsis txhob muaj kev txhim kho crystalluria, qhov kev pom zoo txhua hnub yuav tsum tsis pub dhau, kev haus dej txaus thiab kev saib xyuas cov kua qaub ua kua tseem ceeb heev.

Cov Tshuaj Pharmacokinetics

Thaum noj ntawm qhov ncauj, ciprofloxacin yuav luag tag thiab nqus sai los ntawm cov hnyuv (feem ntau hauv cov jejunum thiab duodenum). Noj yooj yim rau kev nqus, tab sis tsis cuam tshuam rau bioavailability thiab qhov siab tshaj plaws. Bioavailability yog 50-85%, thiab qhov ntim ntawm kev faib tawm yog 2-3 txog l / kg. Ciprofloxacin khi rau cov ntshav plasma ntau npaum li kwv yees li 20-40%. Qhov qib siab tshaj plaws ntawm lub zog hauv lub cev thaum noj ntawm qhov ncauj yog mus txog tom qab kwv yees li 60-90 feeb. Qhov siab tshaj plaws tau tso cia yog kab ntsig ntsig txog koob tshuaj thiab koob tshuaj ntawm 1000, 750, 500 thiab 250 mg yog 5.4, 4.3, 2.4 thiab 1.2 μg / ml, feem. 12 teev tom qab noj 750, 500 thiab 250 mg, cov ntsiab lus ntawm ciprofloxacin hauv plasma yog txo rau 0.4, 0.2 thiab 0.1 μg / ml, feem.

Cov tshuaj muaj peev xwm faib tau zoo hauv cov ntaub so ntswg ntawm lub cev (tsis suav nrog cov ntaub so ntswg enriched hauv cov rog, piv txwv li, cov ntaub so ntswg hlab ntsha). Nws cov ntsiab lus hauv cov nqaij yog 2-12 lub sijhawm siab dua hauv ntshav ntshav. Cov tshuaj kho mob muaj nyob rau ntawm daim tawv nqaij, qaub ncaug, kua dej peritoneal, tonsils, pob txha mos thiab cov kua dej synovial, pob txha thiab cov leeg nqaij, plab hnyuv, nplooj siab, tsib lub plab, tsib lub zais zis, lub raum thiab lub plab, kab mob hauv lub plab thiab lub plab me me (tsev menyuam, zes qe menyuam thiab qe ntshav). hlab ntshav, endometrium), cov ntaub so ntswg ntawm lub qog prostate, kua dej ua kua, zais pa ntawm lub ntsws, daim ntaub ntsws.

Ciprofloxacin nkag mus rau hauv cov kua dej ntawm cerebrospinal hauv ntau qhov me me, qhov twg nws cov ntsiab lus hauv qhov tsis muaj txheej txheem nyob rau hauv daim npluag qhwv yog 6-10% ntawm qhov ntawd hauv cov ntshav ntshav, thiab nrog foci uas twb muaj lawm, nws yog 14-37%.

Ciprofloxacin tseem nkag mus rau hauv cov qog ntshav, pleura, kua dej o, peritoneum thiab dhau ntawm cov txiaj ntsig. Nws cov kev mob siab hauv cov ntshav neutrophils yog 2-7 zaug siab dua hauv ntshav dej. Cov tshuaj sib xyaw ua ke yog cov tshuaj tiv thaiv hauv lub siab txog thaj tsam li 15-30%, ua rau lub cev tsis muaj zog (formylcycrofloxacin, diethylcycrofloxacin, oxociprofloxacin, sulfociprofloxacin).

Ib nrab-lub neej ntawm ciprofloxacin yog li 4 teev, nrog mob raum tsis ua haujlwm nce mus txog 12 teev. Nws yog tsuas yog tawm los ntawm lub raum los ntawm kev ua pa rau tubular kev ua kom tiav thiab tubular pom nyob rau hauv daim ntawv tsis hloov pauv (40-50%) thiab hauv daim ntawv ntawm metabolites (15%), qhov seem yog dhau los ntawm kev mob plab hnyuv. Qhov me me ntawm ciprofloxacin yog tawm hauv niam cov kua mis. Lub raum tshem tawm yog 3-5 ml / min / kg, thiab tag nrho kev tshem tawm yog 8-10 ml / min / kg.

Hauv kev mob raum tsis ua haujlwm (CC ntau dua 20 ml / min), qib ntawm kev nthuav dav ntawm ciprofloxacin los ntawm ob lub raum poob, tab sis nws tsis tuaj yeem nkag mus hauv lub cev vim tias muaj kev kho mob ntxiv nyob rau hauv cov metabolism ntawm cov tshuaj no thiab nws cov kev nthuav tawm los ntawm txoj hnyuv hauv lub plab.

Thaum nqa tawm qhov tso dej ntawm cov tshuaj nyob rau hauv ib koob ntawm 200 mg, qhov siab tshaj plaws ntawm ciprofloxacin ntawm 2.1 μg / ml tau mus txog tom qab 60 feeb. Tom qab kev tswj hwm ntshav, cov ntsiab lus ntawm ciprofloxacin hauv cov zis thaum thawj 2 teev tom qab Txoj kev lis ntshav muaj yuav luag 100 zaus ntau dua hauv cov ntshav ntshav, uas ntau tshaj qhov tsawg tshaj plaws inhibitory concentration rau feem ntau cov kab mob ntawm cov mob txeeb zig.

Thaum ua ntawv thov saum toj no, ciprofloxacin nkag mus rau hauv cov ntaub so ntswg ntawm lub qhov muag: chav ntxig rau sab hauv thiab lub qhov muag, tshwj xeeb tshaj yog nrog kev puas tsuaj rau lub corneal epithelium. Thaum nws puas ntsoog, cov tshuaj muaj ntau nyob hauv nws ntau qhov uas tuaj yeem rhuav tshem feem ntau ntawm cov neeg ua hauj lwm ua rau mob ua paug.

Tom qab ib qho kev tawm tsam, cov ntsiab lus ntawm ciprofloxacin hauv cov dej noo ntawm anterior chav ntawm lub qhov muag tau txiav txim siab tom qab 10 feeb thiab yog 100 μg / ml. Qhov siab tshaj plaws ntawm qhov sib xyaw nyob hauv cov dej noo ntawm chav tsev anterior tau mus txog tom qab 1 teev thiab tau sib npaug li 190 μg / ml. Tom qab 2 teev, kev ua kom lub siab ntawm ciprofloxacin pib txo qis, tab sis nws cov nyhuv hauv cov tshuaj tiv thaiv corneal ntev ntev thiab kav ntev li 6 teev, nyob rau hauv qhov chaw noo ntawm chav tsev anterior - txog 4 teev.

Tom qab instillation, soj ntsuam systemic ntawm ciprofloxacin tej zaum yuav pom. Thaum siv nyob rau hauv daim ntawv ntawm lub qhov muag poob 4 zaug hauv ib hnub nyob rau hauv ob lub qhov muag rau 7 hnub, qhov nruab nrab ntawm cov tshuaj yeeb hauv cov ntshav plasma tsis dhau 2-2.5 ng / ml, thiab qhov siab tshaj yog tsawg dua 5 ng / ml.

Kev siv cov kab ke (ntsiav tshuaj, tov rau Txoj kev lis ntshav, mloog zoo rau kev npaj ntawm tov rau Txoj kev lis ntshav)

Hauv cov neeg mob cov neeg laus, ciprofloxacin yog siv rau kev kho mob thiab tiv thaiv kev kis mob thiab kis mob los ntawm cov kab mob ntxim nyiam:

mob ntsws (mob ntsws ib theem thiab mob hnyav), mob ntsws, mob ntsws, mob ntsws, cystic fibrosis thiab lwm yam mob ua pa,
frontitis, sinusitis, pharyngitis, otitis media, sinusitis, tonsillitis, mastoiditis thiab lwm yam kev kis mob ntawm cov kabmob ENT,
pyelonephritis, cystitis thiab lwm yam mob ntawm lub raum thiab mob txeeb zig,
adnexitis, kab mob gonorrhea, prostatitis, mob chlamydia thiab lwm yam mob ntawm pelvic plab hnyuv siab raum thiab caj,
cov kab mob ntawm lub plab voos hauv lub plab (lub plab zom plab), tsib lub plab, lub plab hauv plab, thiab lwm yam kev kis mob ntawm lub plab zom mov,
mob voos, mob kub hnyiab, ua paug, mob txhab, phlegmon thiab lwm yam kev kis mob ntawm cov tawv nqaij thiab cov nqaij mos.
septic mob caj dab, osteomyelitis thiab lwm yam mob ntawm cov pob txha thiab pob qij txha,
kev phais mob (txhawm rau tiv thaiv mob),
Mob ntsws pulmonary anthrax (rau kev tiv thaiv thiab kho mob),
kis kab mob tiv thaiv keeb kwm ntawm kev txhaj tshuaj tiv thaiv kab mob tshwm sim los ntawm kev kho mob nrog cov tshuaj tiv thaiv kab mob los yog nrog neutropenia.

Rau cov menyuam yaus hnub nyoog 5 txog 17 xyoo, Ciprofloxacin yog qhov ua haujlwm rau kev mob ntsws rau txoj kev mob ntsws rau kev kho mob ntawm cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa, nrog rau kev tiv thaiv thiab kho mob ntsws ntsws (Bacillus anthracis).

Ib qho kev daws teeb meem rau Txoj kev lis ntshav thiab mloog zoo rau kev npaj ntawm kev daws rau Txoj kev lis ntshav kuj tseem siv rau kev kis kab mob ntawm qhov muag thiab kev kis tus kab mob ntawm lub cev - sepsis.

Cov ntsiav tshuaj tau muab rau KFOR (xaiv cov hnyuv ua paug) rau cov neeg mob uas tsis muaj zog tiv thaiv kab mob tsawg.

Cov tshuaj pleev (qhov muag qhov muag, qhov muag thiab pob ntseg pob ntseg)

Ciprofloxacin tee siv rau kev kho mob thiab tiv thaiv kev tiv thaiv kev sib kis hauv qab no los ntawm cov kab mob me me uas nkag rau ciprofloxacin:

ophthalmology (mob qhov muag, mob qhov muag thiab pob ntseg): blepharitis, subacute thiab mob pob txha mos, mob blepharoconjunctivitis, keratitis, keratoconjunctivitis, meibomite (barley), mob dacryocystitis, kab mob sib kis ntawm cov pob txha, kab mob sib kis ntawm cov pob txha, thiab mob ntawm qhov muag vim mob. ophthalmic phais,
otorhinolaryngology (mob qhov muag thiab pob ntseg pob ntseg): kev tshaj tawm sab nraud otitis, kev kho mob ntawm cov teeb meem sib kis hauv lub sijhawm postoperative.

Zaj duab xis-coated ntsiav tshuaj

Ciprofloxacin ntsiav tshuaj noj tom qab noj mov, nqos tag nrho, nrog kua me me. Kev noj cov ntsiav tshuaj ntawm lub plab khoob ua rau nrawm nrawm ntawm kev nqus ntawm cov khoom nquag.

Cov tshuaj pom zoo: 250 mg 2-3 zaug hauv ib hnub, nrog rau muaj mob hnyav - 500-750 mg 2 zaug ib hnub (1 zaug hauv 12 teev).

Dosage raws li tus kab mob / mob:

mob txeeb zig: ib hnub ob zaug, 250-500 mg nyob rau ib chav li 7 txog 10 hnub,
prostatitis mob ntsws: ob zaug ib hnub ntawm 500 mg rau 28 hnub,
kuaj tsis tau tus kab mob gonorrhea: 250-500 mg ib zaug,
gonococcal kis mob sib xyaw nrog tus mob chlamydia thiab mycoplasmosis: ob zaug ib hnub (1 zaug hauv 12 teev) 750 mg hauv ib chav kawm txij li 7 txog 10 hnub,
chancroid: ib hnub ob zaug, 500 mg rau ob peb hnub,
meningococcal carriage hauv nasopharynx: 500-750 mg ib zaug,
tus kab mob salmonella mob ntev: ob zaug ib hnub, 500 mg ib qho (yog tias tsim nyog, nce txog 750 mg) hauv chav kawm txog 28 hnub,
mob hnyav (mob cystic fibrosis, ua mob rau lub plab, pob txha, pob qij txha) los ntawm pseudomonads lossis staphylococci, mob ntsws zoo los ntawm tus kab mob streptococci, mob chlamydial ntawm cov mob genitourinary: ob zaug ib hnub (1 zaug hauv 12 teev) ntawm koob tshuaj 750 mg (kev kho mob rau osteomyelitis tuaj yeem ntev txog 60 hnub)
kev kis mob ntawm tus mob plab hnyuv tshwm sim los ntawm Staphylococcus aureus: ob zaug ib hnub (1 zaug hauv 12 teev) ntawm kev noj tshuaj ntawm 750 mg hauv ib chav ntawm 7 txog 28 hnub,
cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa rau cov menyuam yaus hnub nyoog 5-17 xyoo nrog mob ntsws pulmonary cystic fibrosis: ob zaug ib hnub twg ntawm 20 mg / kg (qhov siab tshaj plaws ib hnub - 1500 mg) hauv ib chav ntawm 10 txog 14 hnub,
Mob ntsws pulmonary anthrax (kev kho mob thiab kev tiv thaiv): ob zaug ib hnub rau cov menyuam 15 mg / kg, cov neeg laus 500 mg (cov koob tshuaj ntau tshaj: ib leeg - 500 mg, txhua hnub - 1000 mg), chav kawm ntawm kev kho mob - txog 60 hnub, pib noj tshuaj Nws yuav tsum yog kiag tom qab kis tau tus kab mob (xav tias lossis paub tseeb).

Qhov siab tshaj plaws niaj hnub noj ntawm ciprofloxacin hauv lub raum tsis ua haujlwm:

kev tshem tawm creatinine (CC) 31-60 ml / min / 1.73 m 2 los yog cov ntshav creatinine ntawm 1.4-1.9 mg / 100 ml - 1000 mg,
KK 2 lossis ua kom cov ntshav creatinine concentration> 2 mg / 100 ml - 500 mg.

Cov neeg mob uas mob ntshav qab zib - lossis mob plab lim ntshav yuav tsum noj cov ntsiav tshuaj tom qab lub lim ntshav tas li.

Cov neeg laus yuav tsum tau txhaj tshuaj kom tsawg dua 30%.

Kev daws rau Txoj kev lis ntshav, mloog zoo rau kev npaj ntawm ib qho kev daws rau infusion

Cov tshuaj yog muab rau cov leeg, maj mam, mus rau hauv txoj hlab ntshav loj, qhov no txo txoj kev pheej hmoo ntawm cov teeb meem ntawm qhov chaw txhaj tshuaj. Nrog kev qhia txog 200 mg ntawm ciprofloxacin, Txoj kev lis ntshav kav ntev li 30 feeb, 400 mg - 60 feeb.

Ua ntej siv, mloog zoo rau kev npaj ntawm kev daws teeb meem yuav tsum tau diluted rau qhov ntim tsawg tshaj plaws ntawm 50 ml hauv kev daws teeb meem hauv qab no: 0.9% sodium chloride tov, Ringer tov, 5% lossis 10% dextrose tov, 10% kev daws teeb meem, 5% dextrose daws nrog 0.225 –0.45% kev daws sodium chloride.

Txoj kev daws teeb meem yog muab rau ib leeg los yog ua ke nrog kev daws teeb meem sib xws: 0.9% sodium chloride tov, Ringer thiab Ringer Lactate tov, 5% lossis 10% dextrose tov, 10% kev daws teeb meem, 5% dextrose kev daws teeb meem los ntawm 0.225–0.45 % daws ntawm sodium chloride. Txoj kev hais daws tau tom qab sib tov yuav tsum tau siv kom nrawm li nrawm txhawm rau txhawm rau tuav nws cov kev tsis haum xeeb.

Yog tias muaj qhov tsis lees paub tseeb ntxiv nrog lwm qhov kev daws / tshuaj, ciprofloxacin Txoj kev lis ntshav yog muab tshuaj cais rau nyias. Pom cov cim ntawm kev tsis sib haum yog cov nag lossis daus, ua kom huab lossis tshem tawm ntawm cov kua. Qhov ntsuas ntawm hydrogen (pH) ntawm ciprofloxacin infusion daws yog 3.5-4.6, yog li nws tsis sib haum nrog txhua qhov kev daws teeb meem / kev npaj uas lub cev lossis tshuaj tsis zoo ntawm cov pH qhov tseem ceeb (kev kho teeb meem heparin, penicillins), tshwj xeeb nrog cov tshuaj pH-hloov kho mus rau alkaline sab. Vim tias cia ntawm txoj kev daws teeb meem ntawm qhov kub tsawg, qhov tsim ntawm ib lub cev sai sai ntawm chav sov yog ua tau. Nws tsis pom zoo kom muab cov kua roj tov rau hauv lub tub yees thiab kom nws khov, vim tias tsuas yog cov tshuaj ntxuav thiab pob tshab tsim nyog siv.

Cov tshuaj pom zoo kom noj tshuaj rau ciprofloxacin rau cov neeg mob laus:

mob ntsws ua pa: nyob ntawm tus mob ntawm tus neeg mob thiab qhov hnyav ntawm cov chav kawm ntawm kev kis mob - 2 lossis 3 zaug hauv ib hnub, 400 mg txhua,
cov kab mob sib kis ntawm cov kab mob genitourinary: mob hnyav, tsis mob - 2 zaug hauv ib hnub los ntawm 200 txog 400 mg, nyuaj - 2 lossis 3 zaug hauv ib hnub, 400 mg,
adnexitis, mob hlwv ntev, mob hlab ntsws, mob ntsws sib kis: 2 lossis 3 zaug ib hnub, 400 mg ib zaug,
raws plab: 2 zaug ib hnub, 400 mg ib,
lwm yam mob muaj nyob hauv seem "Cov ntsiab lus qhia rau Siv": 2 zaug hauv ib hnub, 400 mg txhua,
muaj mob hnyav rau lub neej, tshwj xeeb yog cov mob los ntawm Staphylococcus spp., pseudomonas spp., Streptococcus spp., nrog rau mob ntsws uas tshwm sim los ntawm Streptococcus spp., mob peritonitis, kis mob ntawm pob txha thiab pob qij txha, septicemia, kev rov kis mob nrog cystic fibrosis: 400 mg 3 zaug ib hnub ,
mob ntsws (nqus tau pa) daim ntawv ntawm anthrax: 2 zaug hauv ib hnub, 400 mg hauv 60 hnub (rau kev kho thiab kev tiv thaiv).

Kev kho qhov koob tshuaj ciprofloxacin hauv cov neeg mob laus yog coj los nqis qis, nyob ntawm qhov mob hnyav thiab qhov ntsuas ntawm QC.

Txog kev kho mob rau cov menyuam yaus hnub nyoog 5-17 xyoo, cov teeb meem ntawm Pseudomonas aeruginosa los ntawm pulmonary cystic fibrosis pom zoo 3 zaug hauv ib hnub ntawm 10 mg / kg (siab tshaj plaws ib hnub - 1200 mg) rau 10-14 hnub. Txog kev kho thiab tiv thaiv kab mob ntsws anthrax, 2 hnoos ib hnub ntawm 10 mg / kg ntawm ciprofloxacin raug pom zoo (ntau tshaj ib leeg - 400 mg, txhua hnub - 800 mg), chav kawm - 60 hnub.

Qhov siab tshaj plaws niaj hnub noj ntawm ciprofloxacin hauv lub raum tsis ua haujlwm:

kev tshem tawm creatinine (CC) 31-60 ml / min / 1.73 m 2 los yog cov ntshav creatinine ntawm 1.4-1.9 mg / 100 ml - 800 mg,
KK 2 lossis ua kom cov ntshav creatinine concentration> 2 mg / 100 ml - 400 mg.

Rau cov neeg mob ntawm hemodialysis, ciprofloxacin yog muab tam sim ntawd tom qab kev sib kho.

Qhov nruab nrab ntawm kev kho mob ntev:

mob ncauj plab tsis yooj yim - 1 hnub,
kis kab mob ntawm lub raum, tso zis thiab mob plab - txog 7 hnub,
osteomyelitis - tsis pub dhau 60 hnub,
mob ntsws streptococcal (vim tias qhov txaus ntshai ntawm qhov mob tshwm sim qeeb) - tsawg kawg 10 hnub,
mob tawm tsam keeb kwm ntawm kev txhaj tshuaj tiv thaiv kab mob los ntawm kev kho mob nrog cov tshuaj tiv thaiv kab mob - thaum lub sijhawm tag nrho ntawm neutropenia,
lwm yam mob - 7-14 hnub.

Qhov muag dauv, qhov muag thiab pob ntseg poob

Hauv kev xyaum ophthalmic, tee ntawm ciprofloxacin (ophthalmic, ophthalmic thiab pob ntseg) tau nkag rau hauv lub hnab ntim ua ke.

Instillation regimen nyob ntawm seb hom mob thiab qhov mob loj npaum li cas:

mob pob txuv ua ke, mob blepharitis (yooj yim, teev thiab mob), meibomites: 1-2 ncos 4-8 zaug ib hnub rau 5-14 hnub,
keratitis: 1 poob ntawm 6 zaug hauv ib hnub rau 14-28 hnub,
cov kab mob ua paug rau lub ntsej muag: 1 hnub - 1 poob txhua 15 feeb rau thawj 6 teev ntawm kev kho mob, tom qab ntawd 1 poob txhua 30 feeb thaum lub sijhawm sov so, hnub thib 2 - 1 poob txhua teev thaum lub sijhawm tsim, 3 txog 14th hnub - thaum lub sijhawm tsim sijhawm, 1 poob txhua 4 teev. Yog hais tias epithelization tsis tau tshwm sim tom qab 14 hnub ntawm kev kho mob, kev kho mob raug tso cai mus txuas ntxiv rau 7 hnub ntxiv,
dacryocystitis mob: 1 poob 6-12 zaug hauv ib hnub nrog ib chav kawm tsis ntau tshaj 14 hnub,
qhov muag raug mob, suav nrog lub cev txawv teb chaws (kev tiv thaiv ntawm cov teeb meem sib kis): 1 poob 4-8 zaug hauv ib hnub rau 7-14 hnub,
preoperative kev npaj: 1 poob 4 zaug hauv ib hnub rau 2 hnub ua ntej kev ua haujlwm, 1 poob 5 zaug nrog rau kev sib nrug ntawm 10 feeb ua ntej ua haujlwm,
lub sijhawm tom qab (tiv thaiv kev kis mob): 1 poob 4-6 zaug hauv ib hnub rau tag nrho lub sijhawm, feem ntau li ntawm 5 txog 30 hnub.

Hauv otorhinolaryngology, cov tshuaj (lub qhov muag thiab pob ntseg pob ntseg) yog instilled rau sab nraud cov kav dej sab nraud, muaj yav tas los ua tib zoo ntxuav nws.

Pom zoo kom noj raws txoj cai: 2-4 zaug hauv ib hnub (lossis ntau dua, raws li tsim nyog) rau 3-4 tee. Lub sijhawm ntawm kev kho mob yuav tsum tsis pub tshaj 5-10 hnub, tshwj tsis yog thaum cov ntoo hauv zos yog qhov nkag siab, tom qab ntawd kev txuas ntxiv mus yog qhov raug tso cai.

Rau cov txheej txheem, nws raug nquahu kom nqa tshuaj tov rau chav tsev kub lossis qhov kub hauv lub cev kom tsis txhob xeb lub ntsej muag. Tus neeg mob yuav tsum pw ntawm nws ib sab, tawm tsam pob ntseg uas cuam tshuam, thiab nyob twj ywm hauv txoj haujlwm no li 5-10 feeb tom qab kev txhim kho.

Qee zaum, tom qab ua kom huv hauv zos ntawm cov kav dej sab nraud, nws raug tso cai rau muab cov paj rwb hle rau hauv cov tshuaj Ciprofloxacin rau hauv pob ntseg thiab khaws cia rau ntawd kom txog rau thaum txoj kev txhim kho tom ntej.

Yeeb tshuaj sib cuam tshuam

Vim tias qhov kev ua haujlwm siab ntawm Ciprofloxacin ntau dua thiab muaj qhov pheej hmoo tsis zoo ntawm kev sib cuam tshuam nrog tshuaj, qhov kev txiav txim siab txog kev sib koom tes nrog lwm cov tshuaj / yeeb tshuaj yog tsim los ntawm tus kws kho mob tuaj koom.

Analogues ntawm Ciprofloxacin nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj: Quintor, Procipro, Ceprova, Ciprinol, Ciprobay, Ciprobid, Ciprodox, Ciprolet, Cipropan, Cifran, thiab lwm yam.

Analogues ntawm kev daws rau kev lis ntshav thiab mloog zoo rau kev npaj ntawm kev daws rau kev lis ntshav ntawm Ciprofloxacin: Basigen, Ififpro, Quintor, Procipro, Tseprova, Ciprinol, Tsiprobid, thiab lwm yam.

Kev ntsuas ntawm ophthalmic / ocular thiab pob ntseg tee Ciprofloxacin: Betaciprol, Rocip, Ciprolet, Ciprolon, Cipromed, Ciprofloxacin-AKOS.

Cov lus thiab cov xwm txheej ntawm kev cia

Khaws rau hauv qhov chaw qhuav, tsaus ntawm qhov kub txog li 25 ° C, kev daws rau Txoj kev lis ntshav, mloog zoo thiab poob qis - tsis txhob cia kom khov. Khaws tsis ncav cuag ntawm cov menyuam yaus.

Lub txee lub neej ntawm cov ntsiav tshuaj yog los ntawm 2 txog 5 xyoos (nyob ntawm tus tsim khoom lag luam), kev daws teeb meem thiab mloog zoo - 2 xyoo, qhov muag / qhov muag thiab pob ntseg pob ntseg - 3 xyoos.

Tom qab qhib lub raj mis, khaws lub qhov muag thiab pob ntseg tsis pub ntev tshaj 28 hnub, tso kua muag tawm tsis pub ntev tshaj 14 hnub.

250 lossis 500 mg ntsiav tshuaj

Cov ntsiav tshuaj yuav tsum tau noj rau ntawm lub plab khoob, tsis txhob zom thiab haus nrog dej. Tus txheej txheem koob tshuaj yog 250 mg 2-3 zaug ib hnub. Hauv kev kis mob hnyav, nws raug nquahu kom noj 500-750 mg ntawm cov tshuaj txhua 12 teev (2 zaug hauv ib hnub).

Kev pom zoo koob tshuaj ciprofloxacin nyob ntawm seb hom mob, mob hnyav, tus mob, lub cev, lub raum ua haujlwm, qhov hnyav thiab lub hnub nyoog ntawm tus neeg mob.

Hauv txoj kev kho mob tsis yooj yim cuam tshuam ntawm lub raum thiab mob txeeb zig, 250 mg ntawm Ciprinol yuav tsum noj 2 zaug ib hnub rau 7-10 hnub, nrog cov mob hnyav - 500 mg 2 zaug hauv ib hnub rau 3 hnub.

Hauv cov kab mob prostatitis ntev, 500 mg ntawm cov tshuaj yog tawm 2 zaug hauv ib hnub rau 28 hnub.

Txog kev kho mob kis thiab kab mob ntawm cov pa hauv qis ntawm qhov mob nyhav, nws pom zoo kom noj 250-500 mg ntawm Ciprinol 2 zaug hauv ib hnub. Hauv kev kho cov mob hnyav dua, cov koob tshuaj tau nce rau 750 mg 2 zaug ib hnub.

Hauv kev mob gonorrhea, ib koob tshuaj 250-500 mg ntawm ciprofloxacin yog kho. Yog hais tias muaj mob gonococcal nrog cov mob mycoplasma thiab chlamydia, tom qab ntawd qhov kev pom zoo yog 750 mg ntawm cov tshuaj txhua 12 teev (sijhawm tswj hwm yog 7 txog 10 hnub).

Nrog chancroid, nws raug nquahu kom noj 500 Ciprinol 2 zaug hauv ib hnub rau ob peb hnub.

Ib koob tshuaj ciprofloxacin nrog tus neeg nqa tshuaj ntawm Salmonellatyphi yog 250 mg, txawm li cas los xij, yog tias tsim nyog, nws tuaj yeem raug nce ntxiv txog 500 lossis 750 mg. Qhov ntau zaus ntawm kev tswj hwm yog 2 zaug hauv ib hnub, lub sijhawm ua haujlwm ntawm kev kho mob yog 4 lub lis piam.

Hauv kev kis mob ntawm lub plab pob txha, osteomyelitis thiab lwm yam kev kis mob hnyav, 750 mg ntawm cov tshuaj yog kws kho 2 zaug hauv ib hnub. Lub sijhawm ntawm kev kho tus mob osteomyelitis tuaj yeem mob txog li 2 hlis.

Txhawm rau kho mob plab hnyuv los ntawm Staphylococcus aureus, 750 mg ntawm Ciprinol yuav tsum noj txhua 12 teev rau 7-28 hnub.

Nrog cov neeg mob hauv plab zom mov, 500 mg ntawm ciprofloxacin yog kho 2 zaug hauv ib hnub rau 5-7 hnub (qee kis txog 14 hnub).

Hauv kev kis mob ntawm lub pob ntseg, lub caj pas thiab lub qhov ntswg, qhov koob tshuaj yog nyob ntawm qhov mob hnyav ntawm cov kab mob: mob nruab nrab - ntawm 250 txog 500 mg, mob hnyav - los ntawm 500 txog 750 mg. Cov tshuaj tau coj 2 zaug hauv ib hnub.

Txog kev kho mob ntawm cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa hauv cov menyuam yaus mob ntsws ntsig txog 5 txog 17 xyoo, nws raug nquahu kom siv ciprofloxacin ntawm kev noj tshuaj ntawm 20 mg rau 1 kg ntawm qhov hnyav (ntau kawg yog 1500 mg). Thaum zoo li no, Ciprinol noj 2 zaug hauv ib hnub rau 10-14 hnub.

Hauv kev tiv thaiv kev kis tus kab mob thaum phais mob, 500-750 mg ntawm Ciprinol raug xaj 1-1.5 teev ua ntej kev phais mob.

Txog kev tiv thaiv thiab kho cov mob anthrax, cov neeg mob laus tau hais tseg 500 mg ntawm ciprinol 2 zaug hauv ib hnub, cov menyuam yaus - 15 mg ntawm ciprofloxacin rau 1 kg ntawm lub cev hnyav 2 zaug hauv ib hnub. Nws yog ib qho tsim nyog yuav tsum pib noj cov tshuaj tam sim ntawd tom qab kis tau tus kab mob (xav tias lossis paub tseeb). Thaum pib theem ntawm kev kho, Nws raug nquahu kom siv cov ntawv foos niam txiv. Lub sijhawm tag nrho ntawm kev kho mob yog 60 hnub.

Feem ntau, chav kawm ntawm kev kho nrog tshuaj yog li ntawm 7 mus rau 10 hnub, txawm li cas los xij, tom qab ua kom qhov kub tsis txias, nws yog ib txwm tsim nyog yuav tsum siv Ciprinol rau lwm 3 hnub.

Cov neeg mob uas mob hnyav heev ntawm lub raum lub raum yuav tsum tau txais ib nrab koob tshuaj. Hauv kev kho mob rau cov neeg mob uas mob raum tsis ua haujlwm, kev noj tshuaj hauv qab no yog kev pom zoo:

KK ntau dua 50 ml / min - qhov ib txwm muab,
CC los ntawm 30 txog 50 ml / min - los ntawm 250 txog 500 mg ntawm Ciprinol ib zaug txhua 12 teev,
KK txij li 5 mus rau 29 ml / min - los ntawm 250 txog 500 mg ntawm qhov tshuaj ib zaug txhua 18 teev,
cov neeg mob ua mob rau peritoneal lim ntshav lossis hemodialysis - ntawm 250 txog 500 mg ntawm ciprofloxacin 1 zaug hauv 24 teev

750 mg ntsiav tshuaj

Cov ntsiav tshuaj yuav tsum tau noj tom qab noj mov, tsis txhob zom thiab haus nrog dej. Kev pom zoo koob tshuaj ciprofloxacin nyob ntawm seb hom mob, mob hnyav, tus mob, lub cev, lub raum ua haujlwm, qhov hnyav thiab lub hnub nyoog ntawm tus neeg mob.

Thaum kis thiab kis kab mob ntawm cov pa hauv qis ntawm qhov mob hnyav 2 zaug hauv ib hnub, 750 mg ntawm cov tshuaj yog kws kho.

Nrog cov kab mob pyelonephritis nyuaj, nws pom zoo kom noj 750 mg 2 zaug ib hnub. Lub sij hawm ntawm kev kho mob yog los ntawm 10 hnub, thiab hauv cov xwm txheej tshwj xeeb (piv txwv, nrog lub raum ua qog), lub sijhawm kho yuav ntau dua 21 hnub.

Hauv kev kis mob hnyav ntawm cov tawv nqaij thiab cov nqaij mos, cov tshuaj noj 2 zaug ib hnub rau 750 mg. Lub chav kawm ntawm kev kho mob yog 7-14 hnub.

Hauv cov qauv mob hnyav ntawm pob txha thiab mob sib koom tes (mob pob txha caj dab, txha nqaj qaum), 750 mg ntawm Ciprinol raug xaj 2 zaug ib hnub. Lub sijhawm kho mob osteomyelitis yog li 2 lub hlis.

Rau kev kis mob ntawm qhov chaw mos thiab pelvic plab hnyuv siab raum, cov tshuaj tau pom zoo kom noj 2 zaug hauv ib hnub, 750 mg ib zaug.

Txog rau kev kis mob ntawm lub plab ua rau muaj kab mob gram-tsis zoo, qhov ntau zaus noj ciprofloxacin yog 2 zaug hauv ib hnub ntawm 750 mg.

Thaum kis mob rau cov keeb kwm yav dhau los ntawm kev tiv thaiv kab mob, cov tshuaj tau sau nrog lwm cov tshuaj tua kab mob 2 zaug hauv ib hnub, 750 mg txhua.

Txog kev tiv thaiv kev kis thaum kis mob, 1-1.5 teev ua ntej kev cuam tshuam, kev siv 500-750 mg ntawm ciprofloxacin yog qhia.

Qhov mob hnyav heev cuam tshuam lub sijhawm ntawm kev kho mob, txawm li cas los xij, tom qab qhov ntsuas kub tsis zoo, txoj kev kho yuav tsum txuas ntxiv tsawg kawg peb hnub ntxiv. Lub sijhawm ib txwm siv los kho yog 7-10 hnub.

Siv rau thaum yau

Hauv kev tiv thaiv thiab kho mob ntsig txog mob ntsws anthrax hauv cov menyuam yaus hnub nyoog 5-17 xyoo, 10 mg ntawm ciprofloxacin rau 1 kg ntawm lub cev hnyav tau sau tseg 2 zaug hauv ib hnub. Qhov tshuaj tiv thaiv ntau tshaj txhua hnub rau kev tswj hwm tso dej yog 800 mg (koob tshuaj ntau tshaj yog 400 mg).

Hauv cov neeg mob uas mob ntsws ntsig ntawm cov menyuam hnub nyoog 5-17 xyoo, nyob rau hauv kev kho mob ntawm cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa, 10 mg ntawm ciprofloxacin rau 1 lub cev qhov hnyav kg tau sau tseg rau txhua 8 teev (thaum muab tshuaj rau txhua lub sijhawm 8 teev, qhov ntau kawg yuav tsum tsis pub tshaj 400 mg). Lub chav kawm ntawm kev kho mob yog los ntawm 10 mus rau 14 hnub.

Thaum tsis ua haujlwm lub raum

Cov neeg mob uas tshaj tawm cov kab mob ntawm lub raum ua haujlwm yuav tsum tau txais ib nrab koob ntawm cov tshuaj (saib "Dosage thiab Administration: 250 thiab 500 mg ntsiav tshuaj").

Nrog rau cov ntshiab creatinine cov tshuaj lom ntawm 1.4 / 100 ml thiab 1.9 mg / 100 ml los yog creatinine tshem tawm ntawm 31 ml / min / 1.73 sq. m txog 60 ml / min / 1.73 sq. m, qhov siab tshaj plaws niaj hnub noj tshuaj yog 800 mg.

Rau kev kho mob ntawm cov neeg mob uas muaj lub raum tsis ua haujlwm zoo (kev tshem tawm ntawm creatinine - txog 30 ml / min / 1,73 sq. M, creatinine concentration - ntau dua 2 mg / 100 ml), ib nrab ib koob tshuaj txhua hnub (tsis ntau tshaj 400 mg ib hnub) yog tshuaj. Nrog rau tus mob peritonitis hauv tus neeg mob lub cev tawm ntawm tus mob peritoneal lim ntshav, nws yog ua tau los tswj hwm ciprofloxacin intraperitoneally 4 zaug hauv ib hnub, 50 mg rau 1 liter ntawm lim ntshav.

Kev txheeb xyuas ntawm Ciprinol

Kev tshuaj xyuas ntawm Ciprinol qhia tau hais tias qhov zoo ntawm cov tshuaj no - nws pab kom kov yeej tus kab mob uas ua rau muaj tus kabmob. Nyob rau tib lub sijhawm, ntau cov neeg siv qhia txog kev txhim kho kev phiv (cuam tshuam hauv lub chaw kuaj ntshav, kab mob fungal, dysbiosis). Nws raug sau tseg tias cov tshuaj yuav tsum noj tshwj xeeb thaum lub sijhawm tus kws kho mob tau hais tseg.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj muaj nyob rau hauv ntau hom - qhov muag thiab pob ntseg pob, ntsiav tshuaj, txhaj tshuaj, tshuaj pleev qhov muag. Raws li cov lus qhia, lub hauv paus ntawm lawv txhua tus yog ciprofloxacin hydrochloride. Tsuas yog cov ntau npaum ntawm cov tshuaj thiab cov ntu pabcuam sib txawv. Cov tshuaj muaj sib xyaw ua ke tau piav qhia hauv lub rooj:

Daim ntawv tso tawm Ciprofloxacin (Latin npe - ciprofloxacin)

Ntsiav tshuaj rau qhov ncauj siv

250, 500 lossis 750 mg

Them nrog ib cov xim thaij, cov tsos yog nyob ntawm qhov chaw tsim khoom thiab ntau npaum.

silica colloidal anhydrous,

Qhov muag thiab pob ntseg poob 0.3%

Tsis muaj kob, pob tshab lossis kua dej daj me ntsis. Muag hauv polymer dropper fwj 1 daim hauv thawv.

Txoj kev lis ntshav ampoule tov rau droppers

Cov xim tsis muaj pob tshab lossis cov kua pleev xim me ntsis hauv 100 ml vials.

dilute hydrochloric acid,

Muaj nyob hauv cov hlab hluav taws xob me, ntim hauv cov ntawv los qhia.

Mloog zoo rau kev daws rau infusion

Tsawg me ntsis ntsuab-daj los yog tsis muaj kob uas muaj kua ntshiab li 10 ml hauv lub raj mis. Lawv muab muag ua 5 daim ib pob.

disodium edetate dihydrate,

dej rau kev txhaj tshuaj

Cov chaw muag tshuaj

Raws li cov lus qhia, txhua hom tshuaj muaj cov tshuaj tiv thaiv kab mob loj dav dav ntawm kev ua tawm tsam gram-positive thiab gram-negative aerobic thiab anaerobic cov kab mob, xws li:

Mycobacterium mob ntsws qhuav,
Pob Tsuas Xyooj spp.,
Listeria monocytogenes,
Mycobacterium kansasii,
Chlamydia trachomatis,
Legionella pneumophila,
Mycobacterium avium-intracellulare.

Staphylococci tiv taus methicillin tsis rhiab rau ciprofloxacin. Tsis ntxim rau Treponema pallidum. Tus kab mob Streptococcus pneumoniae thiab tus kab mob Enterococcus faecalis mob siab rau kev haus yeeb tshuaj. Cov tshuaj ua rau cov kab mob me me no los ntawm kev thaiv lawv cov DNA thiab tswj hwm DNA gyrase. Cov tshuaj nquag nkag mus rau hauv lub qhov muag, nqaij, nqaij, tawv nqaij, ntshav, lymph. Tom qab siv sab hauv, bioavailability yog 70%. Qhov nqus ntawm Cheebtsam yog me ntsis cuam tshuam los ntawm kev ua zaub mov noj.

Tsuas tshuaj thiab tswj hwm

Cov txheej txheem kev kho mob yog txiav txim siab los ntawm hom thiab qhov mob sib kis tau. Ciprofloxacin - cov lus qhia rau nws siv qhia 3 txoj kev siv. Cov tshuaj tuaj yeem siv sab nraud, sab hauv lossis los ua kev txhaj tshuaj. Cov haujlwm raum tseem cuam tshuam rau qhov ntau npaum, thiab qee zaum muaj hnub nyoog thiab lub cev hnyav. Rau cov neeg laus dua thiab cov menyuam yaus, nws tau qis dua. Sab hauv tshuaj noj, nws raug nquahu kom ua nws ntawm lub plab khoob. Qhov kev txhaj tshuaj yog siv rau hauv ntau qhov mob hnyav, kom cov tshuaj ua haujlwm sai dua. Raws li cov lus qhia ua ntej lub sijhawm teem tseg, ib qho kev sim ua rau kev nkag siab ntawm cov kab mob coj mus rau cov tshuaj.

Kev phiv thiab tshuaj sib daug

Qhov zoo ntawm txhua hom tshuaj yog kev kam rau ua zoo, tab sis qee tus neeg mob tseem muaj kev phiv tshuaj, xws li:

mob taub hau
tshee hnyo
kiv taub hau
nkees
arousal.

Qhov no feem ntau muaj qhov tshwm sim tsis zoo rau kev siv ciprofloxacin. Cov kev qhia tseem qhia txog cov kev mob tshwm sim tsawg tsawg. Muaj qee kis, cov neeg mob yuav ntsib:

kev mob ntshav siab intracranial,
dej ntas
hws
mob plab
xeev ntuav lossis ntuav
kab mob siab
tachycardia
kev nyuaj siab
khaus tawv
flatulence.

Kev txiav txim los ntawm kev tshuaj xyuas, tshwj tsis yog cov neeg mob, cov neeg mob tau txhim kho bronchospasm, anaphylactic ceeb, Lyell syndrome, creatinine, vasculitis. thaum siv hauv otology, cov tshuaj yuav ua rau tinnitus, dermatitis, mob taub hau. Siv cov tshuaj los kho qhov muag, koj tuaj yeem xav:

txawv teb chaws lub cev kev xav nyob rau hauv lub qhov muag, tsis xis nyob thiab tingling,
cov ntsej muag dawb ntawm lub pob muag,
txuas hyperemia,
lacrimation
txo nyob rau hauv kev pom tseeb tseeb,
photophobia
o ntawm daim tawv muag,
staining ntawm lub qhov muag.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Txhua daim foos uas tso tawm cov tshuaj tawm yog xa tawm los ntawm kws kho mob sau.Ib qhov chaw rau lawv qhov chaw cia khoom yuav tsum nyuaj rau ncav cuag rau cov menyuam yaus thiab qhov teeb meem tsis zoo. Raws li cov lus qhia, kev pom zoo kom sov yog chav sov. Txee lub neej nyob ntawm daim ntawv tso tawm thiab yog: