Amoxicillin Clavulanic acid (Amoxicillin Clavulanic acid)

Kev piav qhia cuam tshuam rau 15.05.2015

• Lub npe Latin: Amoxicillin + Clavulanic ac>

Cov sib xyaw ua ke ntawm kev npaj muaj cov khoom xyaw nquag amoxicillin + clavulanic acid, ntxiv rau ntxiv cov khoom siv ntxiv.

Pharmacodynamics thiab pharmacokinetics

Cov tshuaj sib xyaw ua ke Amoxicillin + Clavulanic acid yog beta-lactamase inhibitor uas muaj cov kab mob bactericidal uas cuam tshuam cov kev sib txuas ntawm cov kab mob phab ntsa. Ntxiv mus, kev ua haujlwm ntawm cov tshuaj muaj tshwm sim cuam tshuam nrog ntau yam kab mob aerobic gram-zoo, suav nrog cov kab mob tsim cov beta-lactamases, piv txwv li: Staphylococcus aureus, qee cov kab mob aerobic gram-tsis zoo: Haemophilus influenzae, Enterobacter spp., Escherichia coli, Klebsiella spp. thiab lwm cov kab mob rhiab, kab mob anaerobic gram-zoo, cov kab mob anaerobic thiab aerobic gram-tsis zoo, thiab lwm yam.

Clavulanic acid muaj peev xwm txwv qhov II-V hom beta-lactamases yam tsis muaj kev tawm tsam 1 hom beta-lactamases uas Pseudomonas aeruginosa, Acinetobacter spp thiab Serratia spp tsim. Tsis tas li, cov khoom siv no yog tsiag ntawv los ntawm lub siab tropism rau penicillinases, uas ua rau thaj chaw ruaj khov nrog enzyme thiab tiv thaiv qhov enzymatic degradation ntawm amoxicillin los ntawm beta-lactamases.

Sab hauv lub cev, txhua yam ntawm cov khoom sib txuam ua kom nrawm nrawm rau hauv cov hnyuv. Txoj kev kho kom zoo yog tsom hauv 45 feeb. Ntxiv mus, hauv ntau cov kev npaj, clavulanic acid, qhov sib piv nrog amoxicillin yog tib koob tshuaj ntawm 125 txog 250, 500 thiab 850 mg hauv ntsiav tshuaj.

Cov tshuaj yog me ntsis khi rau cov ntshav plasma protein: clavulanic acid los ntawm 22-30%, amoxicillin los ntawm 17-20%. Kev zom zaub mov ntawm cov tshuaj no yog nqa tawm hauv lub siab: clavulanic acid los ntawm yuav luag 50%, thiab amoxicillin los ntawm 10% ntawm qhov koob tshuaj uas tau txais.

Cov tshuaj yog tawm tsis tau hloov pauv qhov tseem ceeb los ntawm lub raum tsis pub dhau 6 teev txij li lub sijhawm siv.

Kev ntsuas rau siv

Cov tshuaj no yog sau tseg hauv kev kho mob ntawm ntau yam kab mob:

• txoj hlab pa hauv qab -mob ntsws, mob ntsws, empyema ntawm pleura, mob ntsws o,
• Piv txwv li cov kabmob sinusitis, otitis media, tonsillitis,
• genitourinary system thiab lwm yam kabmob hu ua pelvic plab hnyuv siab raum nrog pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, endometritis, kab mob vaginitis thiab yog li ntawd
• daim tawv nqaij thiab cov ntaub mos muag, piv txwv li, nrog erysipelas, impetigo, kis tus mob thib ob dermatoses, abscesses, phlegmon,
• xyab ntawv thiabosteomyelitis, postoperative mob,kev tiv thaiv tus kab mob hauv kev phais mob.

Cov Yuav Tsum Muaj

Cov tshuaj tsis tau sau tseg rau:

• kev tiv thaiv tsis haum
• mononucleosis mob sib kis,
• phenylketonuria, lub sijhawm uas nws dajntoolossis lub siab ua rau lub siab ua haujlwm los ntawm kev noj cov tshuaj no lossis cov tshuaj zoo sib xws.

Ceev faj yuav tsum tau tawm dag zog thaum kho lactating thiab poj niam cev xeeb tub, cov neeg mob lub siab tsis ua haujlwm, mob plab hnyuv.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Muab cov ntawv Amoxicillin + Clavulanic acid:

• thaij yeeb yaj kiab: oval, biconvex, yuav luag dawb lossis dawb, kos "A" ntawm ib sab, "63" ntawm lwm sab (250 mg + 125 mg ntsiav tshuaj), lossis "64" (500 mg + 125 mg ntsiav tshuaj) ), lossis sau nrog lub ntsej muag pheej hmoo - "6 | 5" (875 mg + 125 ntsiav tshuaj mg), hauv ntu hla ntawv koj tuaj yeem pom lub teeb xim daj ib puag ncig los ntawm lub plhaub dawb lossis yuav luag dawb (7 pcs hauv blisters, 2 blisters hauv cardboard lub thawv) ),
• hmoov rau lub qhov ncauj ncua kev kawm (strawberry): ntau, yuav luag dawb lossis dawb hauv xim (ntawm kev siv ntau npaum li 125 mg + 31.25 mg / 5 ml - 7.35 g txhua qhov hauv cov lam hwj dej ntawm 150 ml, ntawm ib koob tshuaj ntawm 250 mg + 62 5 mg / 5 ml - 14.7 g txhua tus hauv qhov pom zoo 150 ml fwj, txhua lub raj mis hauv lub thawv ntawv thawv),
• hmoov rau qhov kev npaj daws teeb meem rau cov tshuaj (iv) kev tswj hwm: los ntawm dawb mus rau dawb nrog lub xim daj (hauv 10 ml fwj, 1 lossis 10 lub khob hauv lub thawv ntawv thawv, ntim rau tsev kho mob - los ntawm 1 txog 50 lub raj mis hauv lub thawv ntawv) Cov.

Composition 1 ntsiav tshuaj:

• cov tshuaj nquag: amoxicillin (hauv daim ntawv ntawm trihydrate) - 250 mg, lossis 500 mg, lossis 875 mg, clavulanic acid (hauv daim ntawv ntawm potassium clavulanate) - 125 mg,
• Cov khoom siv pabcuam (tsis muaj zog): sodium carboxymethyl hmoov txhuv nplej siab, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, dawb opadra 06V58855 (titanium dioxide, macrogol, hypromellose-15cP, hypromellose-5cP).

Kev sib xyaw ntawm 5 ml ntawm kev ncua (ua los ntawm hmoov rau kev ncua):

• cov khoom xyaw tseem ceeb: amoxicillin (hauv daim ntawv ntawm trihydrate) - 125 mg thiab clavulanic acid (nyob rau hauv cov qauv ntawm potassium clavulanate) - 31.25 mg, lossis amoxicillin - 250 mg thiab clavulanic acid - 62,5 mg,
• Cov khoom siv pabcuam: xanthan ntawm cov pos hniav, silicon dioxide, hypromellose, aspartame, succinic acid, colloidal silicon dioxide, tsw qab.

Cov khoom xyaw nquag nyob rau hauv 1 lub raj mis hmoov rau kev npaj qhov kev daws rau iv kev tswj hwm: amoxicillin - 500 mg thiab clavulanic acid - 100 mg, lossis amoxicillin - 1000 mg thiab clavulanic acid - 200 mg.

Cov Tshuaj Pharmacokinetics

Tom qab noj Amoxicillin + Clavulanic acid sab hauv, cov tshuaj yeeb dej caw sai thiab nqus tawm ntawm txoj hnyuv plab. Qhov siab tshaj plaws yog mus txog tom qab 1-2 teev. Pom zoo nqus tau pom thaum noj cov tshuaj thaum pib noj mov.

Thaum noj ntawm qhov ncauj thiab tso ntshav, cov tshuaj yeeb dej caw muaj ib theem nrab ntawm kev khi rau cov ntshav plasma: amoxicillin - 17-20%, clavulanic acid - 22-30%.

Ob qhov sib xyaw ua ke nrog cov ntim zoo hauv kev faib tawm hauv lub cev thiab cov nqaij. Pom nyob rau hauv lub ntsws, mob pob ntseg hauv nruab nrab, txhaws thiab kua paug ntawm lub cev, lub tsev menyuam, zes qe menyuam. Cov hlab ntshav ua pa, palatine tonsils, kua dej synovial, lub zais pa tawm, cov leeg nqaij, prostate, tsib lub zais zis thiab lub siab ua rau lub zais zais ntawm qhov ua txhaum. Amoxicillin tuaj yeem hla mus rau niam mis, zoo li ntawm penicillins feem ntau. Ib co kua nplaum ntawm clavulanic acid kuj tau pom nyob rau hauv niam mis.

Amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv hniav. Tsis txhob hla cov ntshav-lub hlwb thaiv, muab tias lub meninges tsis kub.

Ob qho kev sib xyaw ua ke hauv lub siab: amoxicillin - kwv yees li 10% ntawm koob tshuaj, clavulanic acid - thaj tsam li 50% ntawm koob tshuaj.

Amoxicillin (50–78% ntawm qhov koob tshuaj) yog tas yuav luag tsis hloov pauv ntawm lub raum los ntawm kev txhaws thiab lub qog ua pa. Clavulanic acid (25–40% ntawm qhov koob tshuaj) yog tawm los ntawm glomerular pom los ntawm lub raum qee qhov nyob rau hauv daim ntawv ntawm metabolites thiab tsis hloov pauv. Ob lub Cheebtsam yog tshem tawm thaum thawj 6 teev. Cov zaub mov me me tuaj yeem tawm ntawm lub ntsws thiab cov hnyuv.

Hauv kev mob raum tsis ua haujlwm, kev tshem tawm ib nrab-lub neej nce: rau amoxicillin - txog 7,5 teev, rau clavulanic acid - txog 4 teev.

Ob lub tshuaj tua kab mob uas siv tau raug tshem tawm thaum lub sijhawm tshuaj lom neeg me, hauv ib qho me me uas siv peritoneal lim ntshav.

Zaj duab xis-coated ntsiav tshuaj

Hauv cov ntsiav tshuaj daim ntawv, cov tshuaj tau qhia rau kev siv qhov ncauj. Rau kev pom zoo thiab txo kev pheej hmoo ntawm phiv los ntawm lub plab zom mov, noj cov ntsiav tshuaj pom zoo thaum pib noj mov.

Tus kws kho mob txiav txim muab cov tshuaj ntau npaum li cas raws tus txheej txheem sib kis, cov hnub nyoog ntawm tus neeg mob, nws lub cev hnyav thiab lub raum kev ua haujlwm.

Yog tias tsim nyog, ua tawm cov kauj ruam kev kho: ua ntej, cov tshuaj Amoxicillin + Clavulanic acid yog tso tshuaj rau tom qab, tom qab uas lawv noj ntawm qhov ncauj.

Cov koob tshuaj pom zoo rau cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav tshaj lub cev ntau dua 40 kg:

• mob mentsis txog rau mob mentsis: 250 mg + 125 mg txhua 8 teev lossis 500 mg + 125 mg txhua 12 teev,
• mob hnyav, mob ua pa: 500 mg + 125 mg 3 zaug hauv ib hnub lossis 875 mg + 125 mg 2 zaug ib hnub.

Qhov siab tshaj plaws txhua hnub koob tshuaj amoxicillin yuav tsum tsis pub tshaj 6000 mg, clavulanic acid - 600 mg.

Kev kho mob tsawg kawg nkaus yog 5 hnub, qhov ntau yog 14 hnub.2 lub lis piam tom qab pib kawm kho, tus kws kho mob ntsuas qhov xwm txheej hauv tsev kho mob thiab, yog tias tsim nyog, txiav txim siab ntawm kev kho mob txuas ntxiv. Lub sijhawm ntawm kev kho rau tsis mob sib luag rau qhov mob otitis yog 5-7 hnub.

Nws yog ib qho tseem ceeb kom nco ntsoov tias 2 ntsiav tshuaj ntawm 250 mg + 125 mg nyob rau hauv cov ntsiab lus ntawm clavulanic acid tsis sib npaug rau 1 ntsiav tshuaj ntawm 500 mg + 125 mg.

Yog tias thaum lub raum tsis zoo ua haujlwm, lub koob tshuaj amoxicillin hloov kho nyob ntawm creatinine tshem tawm (CC):

• QC> 30 ml / min: tsis muaj qhov yuav tsum tau kho
• KK 10-30 ml / feeb: 2 zaug hauv ib hnub, 1 ntsiav tshuaj 250 mg (rau mob me thiab mob qis) lossis 1 ntsiav tshuaj 500 mg,
• QA 30 ml / min.

Cov laus ntawm hemodialysis yog 1 lub tshuaj 500 mg + 125 mg lossis 2 ntsiav tshuaj ntawm 250 mg + 125 mg ib hnub ib zaug. Ib qho ntxiv, ib koob tau raug muab tshuaj rau lub sijhawm lim ntshav thiab lwm qhov tshuaj nyob rau thaum xaus kev sib ntsib.

Hmoov rau kev tshem tawm ntawm qhov ncauj

Ncua Kev Kawm Tawm Amoxicillin + Clavulanic acid feem ntau yog rau cov menyuam yaus hnub nyoog qis dua 12 xyoos.

Hauv daim ntawv ntau npaum li cas, cov tshuaj yog npaj rau hauv lub qhov ncauj. Ib qho kev ncua yog npaj los ntawm cov hmoov: hau thiab txias rau chav sov haus cov dej yog nchuav rau hauv 2/3 lub thauv, shaken zoo, ces lub ntim tau kho rau qhov cim (100 ml) thiab rov tsuj dua los cuam tshuam. Ua ntej txhua tus txais tos, lub vial yuav tsum tau co.

Txhawm rau kev noj tshuaj kom raug, cov khoom siv suav nrog lub hau ntsuas nrog qhov txaus ntshai ntawm 2.5 ml, 5 ml thiab 10 ml. Nws yuav tsum ntxuav nrog dej huv tom qab siv txhua.

Tus kws kho mob txiav txim muab cov tshuaj ntau npaum li cas raws tus txheej txheem sib kis, cov hnub nyoog ntawm tus neeg mob, nws lub cev hnyav thiab lub raum kev ua haujlwm.

Txhawm rau kom zoo rau nqus cov tshuaj nquag thiab txo qhov kev pheej hmoo ntawm phiv los ntawm lub plab zom mov, nws raug nquahu kom tshem tawm Amoxicillin + Clavulanic acid thaum pib noj mov.

Lub sijhawm kho yog tsawg kawg 5 hnub, tabsis tsis tshaj 14 hnub. 2 lub lis piam tom qab pib kawm kho, tus kws kho mob ntsuas qhov xwm txheej hauv tsev kho mob thiab, yog tias tsim nyog, txiav txim siab ntawm kev kho mob txuas ntxiv.

Rau cov menyuam yaus txij li 3 hlis txog 12 xyoos lossis hnyav txog 40 kg, kev ncua sijhawm yog raug saib xyuas los ntawm koob tshuaj 125 mg + 31.25 mg rau 5 ml lossis 250 mg + 62.5 mg rau 5 ml peb zaug ib hnub ntawm 8 teev.

Qhov koob tshuaj txhua hnub rau amoxicillin yog 20 mg / kg, qhov siab tshaj plaws yog 40 mg / kg. Hauv kev txhaj tshuaj qis, cov tshuaj siv rau cov mob tonsillitis, mob ntawm daim tawv nqaij thiab cov nqaij mos. Hauv kev txhaj tshuaj ntau - nrog sinusitis, otitis media, mob kis qis dua ntawm txoj hlab pa, mob txeeb zig, pob txha thiab pob qij txha.

Rau cov menyuam yaus txij thaum yug mus txog 3 hlis, koob tshuaj txhua hnub 30 mg / kg ntawm amoxicillin raug pom zoo. Nws yuav tsum tau muab faib ua 2 koob.

Tsis muaj lus pom zoo hais txog kev noj ntau npaum li cas rau cov menyuam mos thaum yug ntxov.

Thaum lub raum lub raum khiav tsis zoo, qhov tshuaj ntawm amoxicillin yog kho raws QC:

• QC> 30 ml / min: tsis muaj qhov yuav tsum tau kho
• KK 10-30 ml / feeb: 15 mg + 3.75 mg rau ib hlis twg lub cev hnyav ob zaug ib hnub, tab sis tsis ntau tshaj 500 mg + 125 mg ob zaug ib hnub,
• QC

Sab sij huam

Hauv kev kho mob nrog Amoxicillin + Clavualanic acid, ntau qhov kev cuam tshuam yuav tshwm sim uas cuam tshuam rau kev zom zaub mov, ntshav tsim, hlab ntsha hauv lub cev, thiab lwm yam.

Yog li, cov kev mob tshwm sim tuaj yeem tshwm sim: xeev siab, ntuav, raws plab, gastritis, stomatitis, glossitis, cholestatic daj ntseg, kab mob siab, mob thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, kiv taub hau, mob taub hau, hyperactivity, ntxhov siab vim thiab lwm cov tsos mob.

Kev tsim kho hauv zos thiab kev fab tshuaj tsis haum thiab lwm yam tsis tsim nyog xav tau.

Qauv Khoos Kas-Kho Mob Tshooj 1

Ua liaj ua teb. Kev npaj ua ke ntawm amoxicillin thiab clavulanic acid, beta-lactamase inhibitor. Nws ua cov kab mob bactericidal, inhibits kev sib txuas ntawm cov kab mob hauv phab ntsa. Nquag los tawm tsam cov kab mob aerobic gram (nrog rau cov kab mob ua ke-lactamase ua rau cov leeg txawv): Dab Neeg Mus Plob Tsov Cuam Los Hem, aerobic gram-cov kab mob tsis zoo: Tus kab mob Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis. Cov pathogens hauv qab no tsuas yog rhiab. hauv vitro : Staphylococcus epidermidis,Tus kab mob Streptococcus pyogenes, Kab mob Streptococcus anthracis, Streptococcus mob ntsws, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes, anaerobic gram-cov kab mob zoo: Clostridium spp., Peptococcus spp., Peptostreptococcus spp., anaerobic Clostridium spp., Peptococcus spp., Peptostreptococcus spp., aerobic gram-cov kab mob tsis zoo (suav nrog beta-lactamase ua cov leeg tawm): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus ducreyi, Yersinia multocida (yav tas los Pasteurella), Campylobacter jejuni, anaerobic gram-cov kab mob tsis zoo (nrog rau cov kab mob tawm los tsim cov beta-lactamases): Cov ntsiab lus Bacteroides spp., suav nrog Bacteroides fragilis. Clavulanic acid suppresses hom II, III, IV thiab V hom beta-lactamase, tsis tawm tsam tiv thaiv hom I beta-lactamases ua Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid muaj lub siab tropism rau penicillinases, vim tias nws tsim cov chaw ruaj khov nrog cov enzyme, uas tiv thaiv qhov enzymatic degradation ntawm amoxicillin nyob rau hauv kev cuam tshuam ntawm beta-lactamases.

Cov Tshuaj Pharmacokinetics Tom qab lub qhov ncauj tswj hwm, ob qho sib xyaw ua kom nrawm hauv cov hnyuv. Kev noj ib txhij tsis cuam tshuam rau kev nqus. T c_max - 45 feeb Tom qab cov neeg siv qhov ncauj tawm hauv qhov tshuaj 250/125 mg txhua 8 teev C_max amoxicillin - 2.18-4.5 μg / ml, clavulanic acid - 0.8-2.2 μg / ml, ntawm 500/125 mg rau txhua 12 teev C_max amoxicillin - 5.09–7.91 μg / ml, clavulanic acid - 1.19–2.41 μg / ml, ntawm koob tshuaj 500/125 mg txhua 8 teev C_max amoxicillin - 4.94–9.46 μg / ml, clavulanic acid - 1.57–3.23 μg / ml, ntawm ib koob 875/125 mg C_max amoxicillin - 8.82-14.38 μg / ml, clavulanic acid - 1.21–3.19 μg / ml. Tom qab iv coj hauv koob tshuaj 1000/200 thiab 500/100 mg C_max amoxicillin - 105.4 thiab 32.2 μg / ml, ntsig txog, thiab clavulanic acid - 28.5 thiab 10.5 μg / ml. Lub sijhawm nce mus txog qhov siab tshaj plaws cuam tshuam ntawm 1 μg / ml rau amoxicillin zoo ib yam thaum siv tom qab 12 teev thiab 8 teev rau ob leeg rau cov neeg laus thiab menyuam yaus. Kev sib txuas lus nrog ntshav protein: amoxicillin - 17-20%, clavulanic acid - 22-30%. Ob qhov sib xyaw hauv daim siab yog metabolized: amoxicillin - los ntawm 10% ntawm kev muab tshuaj, clavulanic acid - los ntawm 50%. T_1/2 tom qab muab tshuaj ntawm 375 thiab 625 mg, 1 thiab 1.3 teev rau amoxicillin, 1.2 thiab 0.8 teev rau clavulanic acid, ntsig txog. T_1/2 tom qab iv kev tswj hwm ntawm ib koob tshuaj 1200 thiab 600 mg, 0.9 thiab 1.07 h rau amoxicillin, 0.9 thiab 1.12 h rau clavulanic acid, ntsig txog. Nws yog raug tshem tawm feem ntau los ntawm lub raum (glomerular pom thiab tubular tso zis): 50–78 thiab 25 %40% ntawm kev muab tshuaj ntawm amoxicillin thiab clavulanic acid yog tawm tsis hloov, feem, thaum thawj 6 teev tom qab kev tswj hwm.

Cov Khoom Qhia. Cov kab mob kis tau los ntawm cov kab mob rhiab: txo qis ua pa ua pa (mob ntsws, mob ntsws, pleural empyema, mob ntsws ua paug), kis tus kab mob ENT kabmob (sinusitis, tonsillitis, otitis media), kis kab mob rau cov kab mob genitourinary thiab pelvic plab hnyuv (pyelonephritis, pyelitis, cystitis,) urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, kab mob vaginitis, septic rho menyuam, postpartum sepsis, pelvioperitonitis, mos chancre, gonorrhea), mob ntawm daim tawv nqaij thiab cov nqaij mos (erysipelas, impetigo, secondary) tab sis tus kab mob dermatoses, ua paug, cellulitis, mob kab mob), osteomyelitis, postoperative kab mob, kev tiv thaiv ntawm tus kab mob nyob rau hauv kev phais.

Cov Yuav Tsum Muaj Cov tshuaj tiv thaiv tsis haum ntshav (suav nrog rau cephalosporins thiab lwm yam tshuaj tua kab mob beta-lactam), mob mononucleosis (suav nrog cov tsos mob zoo li mob qhua pias), phenylketonuria, lub sijhawm mob daj ntseg lossis lub siab ua tsis zoo vim kev siv tshuaj amoxicillin / clavulanic acid hauv keeb kwm CC tsawg dua 30 ml / min (rau cov ntsiav tshuaj 875 mg / 125 mg).

Nrog ceev faj. Cev xeeb tub, lactation, mob siab rau lub siab ua haujlwm tsis zoo, muaj kab mob plab (nrog rau keeb kwm ntawm colitis cuam tshuam nrog kev siv penicillins), mob raum tsis ua haujlwm.

Qeb ntawm qhov kev txiav txim ntawm tus me nyuam. B

Tsuas tshuaj Sab hauv, hauv / hauv.

Koob tshuaj yog xam los ntawm amoxicillin. Qhov ntau npaum li cas cov tshuaj yog teem ib lub zuj zus nyob ntawm qhov mob hnyav ntawm qhov kawm thiab qhov chaw kis tus kab mob, qhov rhiab ntawm cov kab mob.

Cov menyuam yaus hnub nyoog qis dua 12 xyoos - nyob rau hauv daim ntawv ntawm ncua kev kawm, kua pauj los yog tee rau kev tswj hwm qhov ncauj.

Koob tshuaj ib zaug tau tsim nyob ntawm lub hnub nyoog: menyuam muaj txog 3 hlis - 30 mg / kg / hnub hauv 2 koob tshuaj faib, 3 hlis thiab laus dua - rau kev sib kis mob sib khuav me - 25 mg / kg / hnub hauv 2 faib koob tshuaj lossis 20 mg / kg / hnub hauv 3 koob tshuaj, nrog cov mob hnyav - 45 mg / kg / hnub hauv 2 koob lossis 40 mg / kg / hnub hauv 3 koob.

Cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua: 500 mg 2 zaug / hnub lossis 250 mg 3 zaug / hnub. Hauv kev kis mob hnyav thiab mob ua pa - 875 mg 2 zaug / hnub lossis 500 mg 3 zaug / hnub.

Qhov koob tshuaj txhua hnub ntawm amoxicillin rau cov laus thiab cov menyuam hnub nyoog 12 xyoos yog 6 g, rau cov menyuam hnub nyoog qis dua 12 xyoos - 45 mg / kg lub cev hnyav.

Qhov siab tshaj plaws niaj hnub noj ntawm clavulanic acid rau cov laus thiab cov menyuam hnub nyoog dhau 12 xyoos yog 600 mg, rau cov menyuam hnub nyoog qis dua 12 xyoos - 10 mg / kg lub cev hnyav.

Nrog rau qhov teeb meem nyuaj nqos rau cov neeg laus, siv cov kev ncua raug pom zoo.

Thaum npaj kev ncua, kua thiab tee, dej yuav tsum siv los ua cov kuab tshuaj.

Thaum muab rau cov leeg, cov neeg laus thiab cov hluas uas muaj hnub nyoog tshaj 12 xyoos tau muab 1 g (rau amoxicillin) 3 zaug hauv ib hnub, yog tias tsim nyog 4 zaug hauv ib hnub. Qhov tshuaj tiv thaiv ntau tshaj plaws txhua hnub yog 6 g. Rau cov menyuam muaj 3 hlis txog 12 xyoos - 25 mg / kg 3 zaug hauv ib hnub, muaj mob hnyav - 4 zaug hauv ib hnub, rau cov menyuam muaj txog 3 hlis: lub sijhawm ntxov thiab lub sijhawm tso pw - 25 mg / kg 2 ib zaug ib hnub, nyob rau hauv lub sijhawm postperinatal - 25 mg / kg 3 zaug ib hnub.

Lub sijhawm ntawm kev kho yog txog 14 hnub, mob otitis tawm - txog 10 hnub.

Txog kev tiv thaiv cov kab mob tom qab lub sijhawm ua haujlwm ntev dua 1 teev, ib koob tshuaj 1 g iv yog muab thaum lub sijhawm ua kom loog. Rau kev ua haujlwm ntev dua - 1 g txhua 6 teev rau ib hnub. Hauv kev pheej hmoo siab ntawm kev kis tus kab mob, kev tswj hwm tuaj yeem txuas ntxiv rau ob peb hnub.

Thaum mob raum tsis ua haujlwm, qhov koob tshuaj thiab zaus ntawm kev tswj hwm raug hloov kho nyob ntawm CC: rau CC ntau dua 30 ml / min, tsis tas yuav hloov cov tshuaj, rau CC 10-30 ml / min: sab hauv - 250-500 mg / hnub txhua 12 teev, iv 1 g, tom qab ntawd 500 mg iv, nrog CC tsawg dua 10 ml / min - 1 g, tom qab ntawd 500 mg / hnub iv lossis 250-500 mg / hnub noj hauv ib qho mus. Rau cov menyuam yaus, qhov tshuaj yuav tsum raug txo kom sib npaug.

Cov neeg mob ntawm hemodialysis - 250 mg lossis 500 mg ntawm qhov ncauj hauv ib koob lossis 500 mg iv, ntxiv 1 koob tshuaj thaum lub sijhawm lim ntshav thiab lwm 1 koob tshuaj thaum kawg lim ntshav.

Sab sij huam. Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, gastritis, stomatitis, glossitis, nce kev ua si ntawm "mob siab" transaminases, hauv cov kis mob sib cais - cholestatic jaundice, mob siab, mob siab ua haujlwm (feem ntau yog cov neeg laus, txiv neej, nrog kev kho mob ntev), pseudomembranous thiab hemorrhagic mob plab (tuaj yeem txhim kho tom qab kev kho mob), tus mob enterocolitis, tus nplaig "plaub hau" dub, tsaus nti txha hniav laus.

Hematopoietic plab hnyuv siab raum: ib qho kev hloov rov qab los ntawm prothrombin lub sijhawm thiab los ntshav, lub sijhawm thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

Los ntawm lub paj hlwb: kiv taub hau, mob taub hau, hyperactivity, ntxhov siab vim, hloov tus cwj pwm, nriaj.

Cov tshuaj tiv thaiv hauv zos: qee kis, phlebitis ntawm qhov chaw ntawm iv txhaj.

Kev tsis haum tshuaj: urticaria, ua pob liab liab, tsis tshua muaj - multiforme exudative erythema, anaphylactic shock, angioedema, tsis tshua muaj tshwm sim - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), kev tsis haum vasculitis, mob siab, mob piv txwv tsis tseem ceeb osteoarthritis Cov.

Lwm yam: candidiasis, kev loj hlob ntawm superinfection, interstitial nephritis, crystalluria, hematuria.

Noj ntau dhau. Cov tsos mob: ua txhaum ntawm lub plab thiab cov dej-electrolyte tshuav.

Kev Kho Mob: tsos mob. Hemodialysis siv tau.

Kev sib txuam. Antacids, glucosamine, laxatives, aminoglycosides qeeb thiab txo qhov nqus, ascorbic acid nce ntxiv kev nqus.

Cov kab mob Bacteriostatic (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) muaj cov nyhuv antagonistic.

Tsub kom muaj txiaj ntsig ntawm qhov tsis ncaj ntawm anticoagulants (suppressing lub plab hnyuv microflora, txo cov synthesis ntawm vitamin K thiab prothrombin index). Nrog rau kev tswj hwm tib lub sij hawm ntawm anticoagulants, nws yog ib qho tsim nyog los soj ntsuam cov ntsuas ntawm cov ntshav coagulability.

Txo qhov ua tau zoo ntawm kev tiv thaiv qhov ncauj, tshuaj, thaum lub cev zom zaub mov uas PABA tsim, ethinyl estradiol - txoj kev pheej hmoo ntawm los ntshav "hla kev".

Diuretics, allopurinol, phenylbutazone, NSAIDs thiab lwm yam tshuaj thaiv cov hlab zais pa zais ua rau muaj kev cia siab ntawm amoxicillin (clavulanic acid raug cais tawm tshwj xeeb los ntawm glomerular pom).

Allopurinol ua rau muaj kev pheej hmoo ntawm kev tsim pob khaus tawv nqaij.

Cov lus qhia tshwj xeeb. Nrog chav kawm ntawm txoj kev kho mob, nws yog ib qhov tsim nyog los saib xyuas lub xeev ntawm txoj haujlwm ntawm cov ntshav, daim siab thiab lub raum.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj nrog pluas noj.

Nws muaj peev xwm los tsim superinfection vim kev loj hlob ntawm microflora tsis raug rau nws, uas yuav tsum muaj kev hloov pauv hauv kev siv tshuaj tua kab mob.

Tej zaum yuav muab cov txiaj ntsig tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis. Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis.

Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Hauv cov neeg mob uas muaj lub siab ntsws ua rau penicillins, hla kev tsis haum nrog tshuaj tua kab mob cephalosporin yog ua tau.

Cov kab mob ntawm kev loj hlob ntawm necrotizing colitis hauv cov menyuam tshiab thiab hauv cov poj niam cev xeeb tub nrog lub sijhawm ua ntej ntawm daim nyias nyias tau pom.

Txij li thaum cov ntsiav tshuaj muaj qhov sib npaug ntawm clavulanic acid (125 mg), nws yuav tsum tau yug hauv siab tias 2 ntsiav tshuaj ntawm 250 mg (rau amoxicillin) tsis sib npaug rau 1 ntsiav tshuaj rau 500 mg (rau amoxicillin).

Lub xeev tso npe ntawm cov tshuaj. Daim ntawv tshaj tawm raug cai: hauv 2 ntim. M: Medical Council, 2009. - Feem 2, ntu 1 - 568 s., Tshooj 2 - 560 s.

Dosage Cov Ntawv

Amoxicillin + Clavulanic acid yog tsim nyob rau hauv daim ntawv ntawm:

• coated ntsiav tshuaj nrog ntau cov tshuaj,
• clavulanic acid yog ib txwm 0.125 g,
• amoxicillin
  • 250,
  • 500,
  • 875,
• hmoov rau kev ncua - 156 mg / 5 ml, 312 mg / 5 ml,
• hmoov rau kev txhaj tshuaj nrog ib koob tshuaj 600 mg / 1200 mg.

Hauv kev npaj ua cov nyom, clavulanic acid tau pom muaj cov ntsev potassium - poov tshuaj clavulanate.

Amoxicillin + Clavulanate ntsiav tshuaj muaj qhov khoob khoob khoob pob bongvex, dawb hauv xim nrog kev pheej hmoo. Ntxiv nrog rau cov khoom xyaw nquag, cov muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog:

• cov ntsaws - cov kab mob silicon dioxide, magnesium stearate, microcrystalline cellulose,
• nyob rau hauv plhaub - polyethylene glycol, hypromellose, titanium dioxide.

Amoxicillin + Clavualanic acid, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Kev npaj tsim tau los ntawm cov tshuaj yeeb dej caw no tuaj yeem siv rau kev tswj hwm qhov ncauj, tso ntshav lossis tso ntshav. Hauv qhov no, ntau npaum li cas, kev teem sijhawm thiab sijhawm ntev ntawm kev kho mob yog tsim los xav txog qhov nyuaj ntawm tus kabmob, qhov rhiab ntawm cov kab mob, qhov chaw nyob ntawm tus kab mob thiab cov yam ntxwv ntawm tus neeg mob.

Piv txwv li, cov neeg mob uas muaj hnub nyoog qis dua 12 xyoos raug qhia kom siv cov tshuaj nyob hauv daim ntawv uas muaj kua, ncua kev kawm lossis tso dej, uas yog npaj rau siv sab hauv. Kev noj tshuaj ib zaug yog tsim raws li qhov hnyav thiab hnub nyoog ntawm tus neeg mob.

Kev noj tshuaj ntau kawg txhua hnub ntawm amoxicillin rau cov menyuam yaus txij li 12 xyoos thiab cov neeg mob laus yog 6 g, thiab rau cov neeg mob me uas muaj hnub nyoog qis dua 12 xyoos, nws raug nquahu kom laij ib koob 45 mg rau ib qhov hnyav.

Qhov siab tshaj plaws uas tau tso cai ntawm cov tshuaj clavulanic acid rau cov menyuam yaus txij 12 xyoo thiab cov neeg laus yog 600 mg, thiab rau cov menyuam muaj hnub nyoog qis dua 12 xyoos ntawm tus nqi ntawm 10 mg rau ib kg ntawm qhov hnyav.

Qhov nruab nrab ntawm kev kho mob tuaj yeem yog 10-14 hnub.

Antimicrobial Kev Ua Si Spectrum

Amoxicillin / Clavulanic acid muaj cov kab mob bactericidal, muaj kev tiv thaiv zoo rau cov kab mob thiab protozoa rhiab rau amoxicillin, suav nrog beta-lactamase ua lim ntshav tawm.

Cov kab mob Bicicidal ua tiav tau los ntawm kev cuam tshuam kev coj los ua ke ntawm cov kab mob peptidoglycan tsim nyog rau cov kab mob ntawm phab ntsa.

Ib qho kev pom dav ntawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob amoxicillin nrog clavulanic acid suav nrog:

• aerobes gram-zoo:
  • Staphylococcus sp., Xws li hom mob mesophylline ntawm Staphylococcus aureus,
  • streptococci, pneumococci, hemolytic streptococcus,
  • enterococci,
  • Listeria
• Gram-negative aerobes - Escherichia coli, Haemophilus influenzae, Enterobacter, Klebsiella, Moxarell, Neisseria, Helicobacter pylori,
• gram-zoo anaerobes - clastridia, peptococci,
• gram-negative anaerobes - bacteroids, fusobacteria.

Semi-hluavtaws penicillins, cov yam ntxwv ntawm cov uas tuaj yeem pom ntawm Penicillin Series nplooj ntawv, tau tsim kho tsis kam hauv ntau hom kab mob.

Tau txais cov tshuaj tiv thaiv semisynthetic penicillin amoxicillin yog sau tseg hauv qee qhov kab ntawm Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterococcus, Corynebacter. Tsis muaj kev haum rau amoxicillin / clavulanate chlamydia thiab mycoplasma.

Clavulanic acid tsis ua raws li beta-lactamases, uas yog ua:

• Pseudomonas aeruginosa, muaj "kev xav hauv pawg" uas tso cai rau koj kom yoog sai rau cov tshuaj tua kab mob, txhim kho cov kab mob tiv taus lawv,
• kev ua haujlwm - cov kab mob uas ua rau mob plab hnyuv, mob txeeb zig, ua kom tawv nqaij,
• Acinetobacter (Acinetobacter) - lub txim ntawm septicemia, mob rau daim npluag paj hlwb, uas tau teev nyob rau hauv cov npe ntawm kev muaj kev phom sij tshaj plaws los ntawm WHO lub koom haum xyoo 2017.

Pharmacological kev txiav txim

Cov tshuaj ua haujlwm ntawm cov tshuaj yog nqus sai sai thaum noj ntawm qhov ncauj, thiab thaum twg cov tshuaj tau txhaj rau cov tshuaj ntsiag to. Qhov kev sib xyaw ua ke ntawm kev npaj ua ke Amoxicillin / Clavulanate hauv cov ntshav, tsim nyog rau kev kho mob, yog tsim tom qab 45 feeb.

Cov feem ntawm cov tshuaj khi me ntsis rau cov ntshav protein, thiab 70-80% ntawm cov tshuaj tau txais hauv cov ntshav yog nyob hauv daim ntawv pub dawb.

Metabolize cov tshuaj rau hauv lub siab:

• amoxicillin - 10% ntawm cov tshuaj tua kab mob tau hloov pauv,
• clavulanic rau - uas sib cais 50% ntawm kev nkag los.

Amoxicillin ua rau lub cev tso zis. Ib nrab-lub neej ntawm cov tshuaj ua ke, nyob ntawm lub koob tshuaj, yog 1.3 teev.

Cov tshuaj yog thim tawm thaum noj cov tshuaj raws li cov lus qhia, kwv yees li hauv 6 teev.

Amoxicillin + Clavulanic acid yog tsim rau cov menyuam yaus thiab cov neeg laus hauv daim ntawv ntawm cov ntsiav tshuaj, ncua kev kawm, txhaj tshuaj rau qhov mob hauv qhov koob tshuaj uas tau teev nyob rau hauv cov lus qhia rau kev siv.

Cov lus qhia rau kev tswj hwm ntawm amoxicillin / clavulanate yog kab mob:

• tus kab mob ua pa:
  • zej zog nrhiav cov hlab ntsws, mob ntsws paum,
  • pleurisy
  • mob ntsws
• Cov mob ENT:
  • mob hlab ntsws
  • tonsillitis, tonsillitis,
  • otitis media
• cov plab hnyuv siab raum:
  • pyelonephritis, cystitis,
  • cov hlwv ntawm txoj hlab qe menyuam, endometritis, ncauj tsev menyuam, prostatitis,
  • chancre, kab mob gonorrhea,
• daim tawv nqaij:
  • erysipelas
  • phlegmon
  • impetigo
  • cellulite
  • tsiaj tom
• osteomyelitis
• rau kev tiv thaiv thiab kev kho mob tom qab kis tas.

Cov lus qhia rau kev siv

Lub sijhawm siv tshuaj nrog amoxicillin thiab clavulanic acid yuav tsum tsis pub ntau tshaj 2 lub lis piam. Kev kho mob ntawm otitis media yuav tsum ntev li 10 hnub.

Cov tshuaj hauv cov ntsiav tshuaj yog ntxuav nrog dej thaum noj nrog zaub mov. Lub hmoov rau kev ncua yog diluted nrog dej npau npau, qhov tsawg kawg yog ib nrab ib khob.

Kev ncua yog raug pom zoo rau kev kho mob ntawm menyuam yaus nrog rau cov neeg laus uas muaj teeb meem nqos nyuaj.

Kev noj tshuaj ntau yog xam los ntawm amoxicillin.

Tus kws kho mob rub tawm ib qho kev kho mob ib leeg zuj zus raws li lub hnub nyoog, qhov hnyav, kev ua haujlwm ntawm lub tso zis, thiab thaj chaw mob ntawm qhov chaw txhab.

Nws yuav tsum tau yug los hauv lub siab tias 0.5 g ntawm amoxicillin / 125 mg ntawm clavulanic rau-koj tsis tuaj yeem hloov nrog 2 koob ntawm 250 mg / 125 mg.

Tag nrho tus nqi ntawm clavulanate nyob rau hauv rooj plaub tom kawg yuav muaj ntau dua, uas yuav txo qis qhov mob sib piv ntawm cov tshuaj tua kab mob hauv cov tshuaj.

Cov koob tshuaj txhua hnub yuav tsum tsis pub ntau tshaj:

• amoxicillin:
  • tom qab 12 l - 6 g
  • hauv qab 12 litres - tsis tshaj 45 mg / kg,
• clavulanic rau:
  • dhau 12 l. - 600 mg
  • hluas dua 12 litres - 10 mg / kg.

Cov ntsiav tshuaj rau cov neeg laus, kev qhia

Cov neeg laus, cov menyuam yaus tshaj 40 kg tau sau tseg yog Amoxicillin / Clavulanate raws li cov lus qhia rau kev siv:

• mob sib khuav xwb
  • thrice / d. 0.25 g
  • ob zaug ib hnub. 500 mg
• nrog mob ntsws, mob hnyav:
  • thrice / hnub. 0.5 g
  • ob zaug ib hnub. 0.875 g.

Hmoov rau kev ncua rau menyuam yaus

Cov qauv tseem ceeb rau kev xam cov koob tshuaj ntawm cov tshuaj raws li cov lus qhia yog qhov hnyav thiab hnub nyoog. Amoxicillin / Clavulanic acid yog muab tshuaj rau ib hnub:

• los ntawm yug rau 3 lub hlis. - haus 30 mg / kg thaum sawv ntxov / yav tsaus ntuj,
• 3 hli mus txog 12 l.:
  • mob sib khuav xwb
    • kho nrog 25 mg / kg ob zaug / d.,
    • haus 20 mg / kg 3 r. hauv 24 teev,
  • mob o:
    • haus 45 mg / kg 2 p. / 24 teev.,
    • noj 40 mg / kg 3 p. / 24 teev

Cov menyuam tsis tau muaj 12 xyoos yuav tsum raug tshem tawm peb zaug / hnub. Ib koob tshuaj tib zaug ntawm qhov kev ncua ntawv tiav yog:

• 9 hlis - 2 xyoos - 62,5 mg ntawm amoxicillin,
• los ntawm 2 l. txog li 7 litres - 125,
• 7 l txog 12 litres - 250 mg.

Tus kws kho mob paum tuaj yeem nce lossis txo cov tshuaj ntau npaum li cas nyob ntawm qhov hnyav, hnub nyoog ntawm tus menyuam thiab qhov mob hnyav kis tau.

Kev sib txuam

Hauv kev kho nrog cov tshuaj nyob hauv nrogtshuaj tiv thaiv kab mob, Glucosamine, mob plab thiab aminoglycosides muaj kev ua kom qeeb thiab txo qis hauv kev nqus, thiab ascorbic acid ntawm qhov tsis tooj, nce ntxiv.

Qee cov tshuaj bacteriostatic, xws li: macrolides, lincosamides, chloramphenicol, tetracyclines thiab sulfonamidesua kom pom cov nyhuv antagonistic.

Cov tshuaj muaj peev xwm nce qhov kev ua tau zoo ntawm qhov tsis ncaj ntawm anticoagulants, uas yog nrog los ntawm kev tsuj ntawm plab hnyuv microflora, qhov txo qis hauv qhov kev coj los ua ke ntawm vitamin K thiab prothrombin index. Ua ke nrog anticoagulants yuav tsum ua tib zoo saib xyuas ntawm coagulation ntshav.

Kev txiav txim yog txo qhov ncauj tiv thaiv kev sib deev, ethinyl estradiol, ntxiv rau cov tshuaj uas metabolize PABA, uas ua rau muaj kev pheej hmoo los ntshav. Diuretics, Phenylbutazone, Allopurinol, cov neeg ua hauj lwm thaiv cov tubular tso pa tawm - tuaj yeem nce qhov siab ntawm amoxicillin.

Cov lus qhia tshwj xeeb

Cov kev kho mob hauv chav kawm yuav tsum tau ua raws kev tswj hwm ntawm txoj haujlwm ntawm ntshav, ob lub raum thiab mob siab. Txo txoj kev pheej hmoo ntawm qhov tsis xav ua nyob rau hauv cov zom zaub mov, cov tshuaj yuav tsum noj nrog zaub mov.

Nrog rau kev loj hlob ntawm cov tshuaj-insensitive microflora, superinfection tuaj yeem txhim kho, xav tau kev kho mob kom tsim nyog. Cov txiaj ntsig tsis raug yog qee zaum pom thaum muaj kev txiav txim siab ntawm cov piam thaj hauv cov zis. Cov piam thaj oxidant concentration teeb tsa kev pom zoo.piam thajnyob rau hauv cov muaj pes tsawg leeg zis.

Lub diluted raug muab tshem tawm tuaj yeem khaws cia hauv tub yees, tab sis tsis ntau tshaj 7 hnub, yam tsis muaj khov. Hauv cov neeg mob uas tsis nkag siab tshuaj penicillinsHla kev fab tshuaj ua ke nrog cephalosporin tshuaj tua kab mob.

Cov tshuaj sib xyaw nrog cov ntsiav tshuaj muaj xws li cov nqi ntawm clavulanic acid, uas yog 125 mg, yog li nws yuav tsum tau yug hauv siab tias hauv 2 ntsiav tshuaj ntawm 250 mg txhua tus muaj cov ntsiab lus sib txawv ntawm cov tshuaj, piv rau 500 mg.

Hnub tas sij hawm

Cov analogues loj yog sawv cev los ntawm cov tshuaj: Amovicomb, Amoxivan, Amoxiclav, Quicktab, Amoxicillin trihydrate + Potassium clavulanate, Arlet, Augmentin, Baktoklav, Verklav, Klamosar, Liklav, Medoklav, Panclav, Ranklav, Rapiklav, Taromentin, Fibell, Flemoklav Solutab thiab Lub Ecoclave.

Thaum kho nrog ib qho tshuaj tua kab mob, haus dej cawv yog sib txuam, vim tias qhov no tuaj yeem txo qhov kev ua tau zoo ntawm kev kho thiab nce qhov mob hnyav ntawm kev phiv.

Kev tshuaj xyuas ntawm Amoxicillin + Clavualanic Acid

Raws li koj paub, cov tshuaj tua kab mob yog cov tshuaj sib tham hauv ntau qhov chaw sib tham. Cov neeg mob yuav luag sib npaug txhawj xeeb txog ob qho tib si kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj no. Tib lub sijhawm, kev tshuaj xyuas txog Amoxicillin + Clavualanic acid kev npaj muaj feem ntau zoo.

Tsis muaj leej twg tsis ntseeg qhov ua tau zoo ntawm cov tshuaj tua kab mob no, yog li nws tau raug kho nyob rau hauv kev kho mob ntawm txawm tias cov hom mob uas cuam tshuam ntau tshaj. Txawm li cas los xij, feem ntau cov neeg mob txaus siab clavulanic acid, nws yog dab tsi thiab nws sib xyaw nrog amoxicillin, uas yog, txhim kho lossis muag nws cov nyhuv. Nws yuav tsum raug sau tseg tias qhov khoom no muaj nws tus kheej ua haujlwm tua kabmob.

Tsis tas li, cov tshuaj no feem ntau pom hauv kev sib tham txog kev kho mob ntawm poj niam cev xeeb tub. Tab sis ntau tus kws tshaj lij qhia kom noj cov tshuaj rau lub sijhawm no. AmoxiclavCov. Qhov no kuj tau muaj tseeb los ntawm cov poj niam uas tau kho nrog cov tshuaj no ntau zaug. ntawm cev xeeb tubCov. Raws li txoj cai, kev kho mob ib txwm pab tshem tawm qhov kev ua txhaum yam tsis muaj kev cuam tshuam rau tus neeg mob lossis tus menyuam hauv plab.

Cov tshuaj tua kab mob yog ib feem ntawm ntau txoj kev kho mob cuam tshuam nrog kev kho mob ntawm cov kab mob. Nws yuav tsum nco ntsoov tias kev noj cov tshuaj tsuas yog ua tau tsuas yog qhia los ntawm kws kho mob. Tab sis ua ntej koj yuav tsum txiav txim siab qhov rhiab ntawm lub pathogen rau cov tshuaj no. Tsuas yog tom qab ntawd thiaj li tuaj yeem ua kom muaj txiaj ntsig zoo ntawm kev kho yuav tsum tsis muaj kev phom sij ntxiv rau lub cev.

IV kev txhaj tshuaj, cov lus qhia rau cov laus

Amoxicillin / clavulanic acid yog muab tshuaj rau tom qab 12 xyoos peb zaug hauv ib hnub lossis 4 r. / Hnub hauv ib qho tshuaj:

• nrog mob me ntawm cov kab mob - 1 g,
• Thaum muaj mob hnyav - 1200 mg.

IV txhaj tshuaj rau cov menyuam yaus, cov lus qhia

Ib tug menyuam yaus hnub nyoog qis dua 12 xyoos raug samfwm kom noj tshuaj:

• 3 hlis., Cov menyuam mos uas tsis tau qoos txij li 22 lub lis piam - ob zaug / hnub. 25 mg / kg
• 3 hli mus txog 12 l.:
  • yooj yim txaus - peb zaug hauv ib hnub 25 mg / kg,
  • hauv kev muaj mob hnyav - 4 zaug / hnub. 25 mg / kg.

Kev kho kho yog nqa tawm ntawm qhov tsis tshua muaj creatinine tshem tawm, uas yog ntsuas hauv ml / min.:

• tsawg dua 30 tab sis ntau dua 10:
  • qhov ntau npaum li cas hauv cov ntsiav tshuaj yog 0.25 g –0.5 g tom qab 12 teev.
  • nyob rau hauv / hauv - ob zaug hauv ib hnub, thawj 1 g, tom qab - 0, 5 g,
• tsawg dua 10:
  • hais lus - 0, 25 g lossis 0, 5 g,
  • hauv / hauv - 1 g, tom qab 0.5 g.

Tsuas yog tus kws kho mob tuaj yeem kho qhov ntau npaum li cas raws li cov txiaj ntsig tau los ntawm kev kawm txog kev ua ub no.

Amoxicillin / Clavulanic acid tau tso cai rau kho cov neeg mob hemodialysis. Tsuas tshuaj tom qab 12 l .:

• ntsiav tshuaj - 250 mg / 0.5 g
• hno iv - 0.5 g - 1 lub sijhawm.

Thaum lub sijhawm ua tus txheej txheem hemodialysis thaum pib thiab thaum kawg ntawm kev sib kho, cov tshuaj yuav siv ntxiv rau hauv ib qho tshuaj.

Cov tshuaj sib cuam tshuam

Qhov nqus ntawm Amoxicillin / Clavulanate cuam tshuam thaum siv nrog cov tshuaj:

• antacids - cov tshuaj uas neutralize lub acidity ntawm lub plab,
• aminoglycoside tshuaj tua kab mob,
• mob plab
• glucosamine.

Qhov kev nqus ntawm cov tshuaj vitamin C ntxiv kom zoo dua qub, thaum kev tswj hwm tib lub sijhawm ntawm allopurinol, NSAIDs, calcium channel blockers nce nws cov ntsiab lus hauv cov ntshav, txo cov ntshav siab txhaws rau hauv lub raum.

Amoxicillin / Clavulanate nrog cov tshuaj tua kab mob nrog cov nyhuv bacteriostatic - macrolides, lincosamines, tetracyclines, chloramphenicol - tsis yog kho mob thooj txhij.

Hauv kev kho ntawm Amoxicillin + Clavulanic acid, kev ua haujlwm ntawm kev hloov pauv tau:

• anticoagulants - nce, vim hais tias ntawm cov uas tswj ntshav coagulability yuav tsum,
• qhov ncauj tshuaj tiv thaiv - txo qis.

Kev siv dej cawv tsis pom zoo hauv cov lus qhia rau kev siv Amoxicillin / Clavulanate hauv kev kho mob ntawm cov tshuaj, vim tias qhov no nce lub nra rau daim siab thiab ua rau muaj kev pheej hmoo ntawm phiv.

Cev xeeb tub

Amoxicillin / Clavulanate yog teratogenic hauv chav kawm B. Qhov no txhais tau hais tias txawm hais tias kev tshawb fawb ntawm cov tshuaj tsis qhia txog qhov tshwm sim tsis zoo rau kev tsim tus me nyuam hauv plab, muaj cov ntaub ntawv tsis txaus ntseeg txog kev ua tiav kev nyab xeeb ntawm cov tshuaj.

Amoxillin + Clavulanate yuav tsum siv nruj me ntsis raws li cov lus qhia rau kev siv thiab txheej txheem uas tus kws kho mob sau tseg. Tshaj tawm kev kho mob ntawm Amoxicillin + Clavulanic acid rau cov poj niam cev xeeb tub yog ua tau tsuas yog ua raws li kev taw qhia, suav txog cov txiaj ntsig zoo ntawm cov tshuaj thiab nws cov nyhuv ntawm cov menyuam hauv plab.

Arlet, Amoxiclav, Panclave, Ranklav, Augmentin, Flemoklav Solutab, Quicktab, Klavocin, Moksiklav.

Kev sib piv Amoxicillin clavulanic acid

Analogues ntawm amoxicillin clavulanic acid yog cov kev npaj ua ke uas muaj ntau yam tshuaj tseem ceeb - amoxicillin thiab clavulanic acid, nrog rau ntau tus lej pabcuam, uas yuav txawv rau cov tshuaj sib txawv.

Amoxiclav

Amoxiclav yog cov tshuaj siv tshuaj tua kab mob nrog qhov tshwm sim ntau yam. Nws muaj ob lub ntsiab:

• Amoxicillin - cov tshuaj nquag, tshuaj tua kab mob nws tus kheej,
• Clavulanic acid - muaj cov tshuaj tua kabmob me. Nws lub luag haujlwm tseem ceeb yog tiv thaiv amoxicillin los ntawm cov kev ua phem rau cov tib neeg sab hauv.

Ua raws li daim ntawv tso tawm, ntau cov tshuaj pabcuam ntxiv rau cov tshuaj, ntau npaum ntawm cov khoom tseem ceeb kuj txawv:

• Cov ntsiav tshuaj muaj 250 mg, 875 mg lossis 500 mg ntawm cov tshuaj tua kab mob thiab 125 mg ntawm kua qaub. Cov kev zam: suav nrog cov tshuaj silicon dioxide, triethyl citrate, titanium dioxide, cellulose thiab talc,
• Kev Raug Ncua 5 ml ntawm cov kua tau npaj muaj 125 mg ntawm amoxicillin thiab 31 mg ntawm cov tshuaj tiv thaiv. Txhawm rau cov tshuaj kom nws cov duab thiab saj zoo, citric acid, cellulose, sodium benzoate thiab ntau yam tshuaj tsw qab kuj ntxiv rau nws.

Amoxiclav yog ib qho lus piv txwv ntawm amoxicillin clavulanate, uas tsis txawv hauv nws cov muaj pes tsawg leeg. Nws yog siv rau tib lub pathologies li lwm cov tshuaj tiv thaiv kab mob uas muaj amoxicillin thiab clavulanic acid. Tus nqi ntawm cov tshuaj no yog qis dua me ntsis txoj cai nqe ntawm nws cov analogues. Tab sis ntawm qhov nruab nrab, qhov sib txawv yog qhov tsis txaus ntseeg (50-100 rubles).

• 500 mg ntsiav tshuaj yuav raug nqi 340-360 rubles rau 15 daim,
• Hmoov rau kev tsim khoom ntawm 100 ml ntawm kev ncua yuav raug nqi kwv yees li 300 rubles,
• Ib qho kev daws teeb meem rau kev tswj hwm ntawm niam txiv - 850-900 rubles rau 5 vials uas muaj 1 g ntawm amoxicillin ib qho.

Flemoklav Solutab

Qhov pheej yig dua ntawm cov tshuaj Amoxicillin yog Flemoklav Solutab. Nws muaj pes tsawg leeg tsis txawv ntawm cov ntsiab lus ntawm Amoxiclav, tab sis nws tsuas muaj nyob hauv ntsiav tshuaj daim ntawv xwb. Hauv qhov no, nws tsuas yog tsim nyog rau kev kho mob ntawm cov menyuam laus zog thiab cov laus.

20 ntsiav tshuaj, uas muaj 125 mg ntawm amoxicillin thiab 31 ml ntawm clavulanic acid, tuaj yeem muas ntawm cov khw muag tshuaj rau 300-320 rubles. Cov ntsiab lus siab dua ntawm cov tshuaj tseem ceeb yuav raug nqi ntau dua - 500-520 rubles rau 14 ntsiav tshuaj ntawm 875 mg txhua.

Augmentin yog yeeb tshuaj uas yog ib qho tshuaj noj ntawm amoxicillin clavulanic acid. Lawv cov kev sib xyaw yog cov zoo sib xws - ob lub ntsiab lus, ntxiv rau cellulose, potassium, silicon thiab lwm yam. Txoj cai tswj hwm tus nqi yog kwv yees li qhov ntau ntawm lwm cov cuab yeej zoo sib xws.

Cov Ntawv Tso Tawm:

• Hmoov rau kev ncua,
• Ntsiav tshuaj
• Kev daws rau kev txhaj tshuaj.

Cov qhov txhab kws kho mob loj heev tso cai rau koj xaiv cov tshuaj zoo tshaj plaws. Koj tuaj yeem xaiv lub chaw tsim khoom txawv teb chaws lossis Lavxias, cov tshuaj uas xav tau thiab daim ntawv tso tawm zoo tshaj plaws.

Yog tias koj ntseeg tias cov kev txheeb xyuas, kev hloov pauv rau Amoxicillin clavulanic acid kho zoo nrog txhua qhov kev tiv thaiv kab mob los ntawm daim ntawv teev cov kab mob tau qhia hauv cov lus qhia rau kev siv tshuaj.

Pom yuam kev lawm? Xaiv nws thiab nias Ctrl + Enter

Sib piv cov lus

Analogues ntawm cov tshuaj Amoxicillin + Clavulanic acid

Amoxicillin + Clavulanic acid
Sau cov npe tawm
Amoxicillin + Clavulanic acid (Amoxicillin + Clavulanic acid) Antibiotic-penicillin semi-hluavtaws + beta-lactamase inhibitor Coated ntsiav tshuaj, lyophilisate rau kev npaj ntawm cov tshuaj tov, hmoov rau kev npaj ntawm qhov ncauj ncua, ntsiav tshuaj, hmoov rau kev npaj ntawm cov tshuaj ua kom haum, ntsiav tshuaj ntsiav tshuaj dispersible

Kev npaj ua ke ntawm amoxicillin thiab clavulanic acid, beta-lactamase inhibitor. Nws ua cov kab mob bactericidal, inhibits kev sib txuas ntawm cov kab mob hauv phab ntsa.

Nquag los tawm tsam cov kab mob aerobic gram (nrog rau cov kab mob ua ke-lactamase ua rau cov leeg txawv): Staphylococcus aureus,

Cov kab mob aerobic gram-tsis zoo: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis.

Cov kab mob hauv qab no tsuas yog tiv thiav hauv vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Corynebacterium spp., Listeria monocytogenes, anaerobic pepp.

aerobic gram-cov kab mob tsis zoo (suav nrog beta-lactamase tsim cov kab mob): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseriaioriiferiferiferiferiferiferifer ), Campylobacter jejuni,

anaerobic gram-cov kab mob tsis zoo (suav nrog beta-lactamase ua kev lim tawm): Bacteroides spp., suav nrog Bacteroides fragilis.

Clavulanic acid suppresses hom II, III, IV thiab V beta-lactamases, tsis muaj zog tiv thaiv hom I beta-lactamases, ua los ntawm Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid muaj lub siab tropism rau penicillinases, vim tias nws tsim cov chaw ruaj khov nrog cov enzyme, uas tiv thaiv qhov enzymatic degradation ntawm amoxicillin nyob rau hauv kev cuam tshuam ntawm beta-lactamases.

Cov kab mob kis tau los ntawm cov kab mob rhiab: txo qis ua pa ua pa (mob ntsws, mob ntsws, pleural empyema, mob ntsws ua paug), kis tus kab mob ENT kabmob (sinusitis, tonsillitis, otitis media), kis kab mob rau cov kab mob genitourinary thiab pelvic plab hnyuv (pyelonephritis, pyelitis, cystitis,) urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, kab mob vaginitis, septic rho menyuam, postpartum sepsis, pelvioperitonitis, mos chancre, gonorrhea), mob ntawm daim tawv nqaij thiab cov nqaij mos (erysipelas, impetigo, secondary) tab sis tus kab mob dermatoses, ua paug, cellulitis, mob kab mob), osteomyelitis, postoperative kab mob, kev tiv thaiv ntawm tus kab mob nyob rau hauv kev phais.

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, gastritis, stomatitis, glossitis, nce kev ua si ntawm "mob siab" transaminases, nyob rau hauv cov xwm txheej tsawg - mob siab daj ntseg, mob siab, mob siab (feem ntau hauv cov neeg laus, txiv neej, nrog kev kho mob ntev), pseudomembranous thiab hemorrhagic mob plab (tuaj yeem txhim kho tom qab kev kho), tus mob enterocolitis, tus nplaig "plaub" dub, tsaus ntawm txha hniav laus.

Hematopoietic plab hnyuv siab raum: ib qho kev hloov rov qab los ntawm prothrombin lub sijhawm thiab los ntshav, lub sijhawm thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

Los ntawm lub paj hlwb: kiv taub hau, mob taub hau, hyperactivity, ntxhov siab vim, hloov tus cwj pwm, nriaj.

Cov tshuaj tiv thaiv hauv zos: qee kis, phlebitis nyob ntawm thaj chaw tswj hwm.

Kev tsis haum tshuaj: urticaria, erythematous ua pob, tsis tshua muaj - multiforme exudative erythema, anaphylactic shock, angioedema, tsis tshua muaj mob - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), kev tsis haum tshuaj vasculitis, mob siab, mob piv txwv tsis tseem ceeb osteoarthritis Cov.

Lwm yam: candidiasis, kev loj hlob ntawm superinfection, interstitial nephritis, crystalluria, hematuria.

Daim ntawv thov thiab qhov ntau npaum li cas

Koob tshuaj yog xam los ntawm amoxicillin. Qhov ntau npaum li cas cov tshuaj yog teem ib lub zuj zus nyob ntawm qhov mob hnyav ntawm qhov kawm thiab qhov chaw kis tus kab mob, qhov rhiab ntawm cov kab mob.

Cov menyuam yaus hnub nyoog qis dua 12 xyoos - nyob rau hauv daim ntawv ntawm ncua kev kawm, phoov los yog tee rau kev tswj hwm qhov ncauj.Koob tshuaj ib zaug tau tsim nyob ntawm lub hnub nyoog: menyuam muaj txog 3 hlis - 30 mg / kg / hnub hauv 2 koob tshuaj faib, 3 hlis thiab laus dua - rau kev sib kis mob sib khuav me - 25 mg / kg / hnub hauv 2 faib koob tshuaj lossis 20 mg / kg / hnub hauv 3 koob tshuaj, nrog cov mob hnyav - 45 mg / kg / hnub hauv 2 koob lossis 40 mg / kg / hnub hauv 3 koob.

Cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua: 500 mg 2 zaug / hnub lossis 250 mg 3 zaug / hnub. Hauv kev kis mob hnyav thiab mob ua pa - 875 mg 2 zaug / hnub lossis 500 mg 3 zaug / hnub.

Qhov koob tshuaj txhua hnub ntawm amoxicillin rau cov laus thiab cov menyuam hnub nyoog 12 xyoos yog 6 g, rau cov menyuam hnub nyoog qis dua 12 xyoos - 45 mg / kg lub cev hnyav.

Qhov siab tshaj plaws niaj hnub noj ntawm clavulanic acid rau cov neeg laus thiab cov menyuam hnub nyoog dhau 12 xyoos yog 600 mg, rau cov menyuam hnub nyoog qis dua 12 xyoos - 10 mg / kg lub cev hnyav.

Nrog rau qhov teeb meem nyuaj nqos rau cov neeg laus, siv cov kev ncua raug pom zoo.

Thaum npaj kev ncua, kua thiab tee, dej yuav tsum siv los ua cov kuab tshuaj.

Thaum muab rau cov leeg, cov neeg laus thiab cov hluas uas muaj hnub nyoog tshaj 12 xyoos tau muab 1 g (rau amoxicillin) 3 zaug hauv ib hnub, yog tias tsim nyog 4 zaug hauv ib hnub. Qhov tshuaj tiv thaiv qhov ntau tshaj txhua hnub yog 6 g.

Rau cov menyuam muaj 3 hlis-12 xyoos - 25 mg / kg 3 zaug hauv ib hnub, hauv cov kis hnyav - 4 zaug hauv ib hnub, rau cov menyuam muaj hnub nyoog txog 3 hlis: lub sijhawm ntxov thiab lub sijhawm tso sijhawm - 25 mg / kg 2 zaug hauv ib hnub, hauv lub sijhawm postperinatal - 25 mg / kg 3 zaug ib hnub.

Lub sijhawm ntawm kev kho yog txog 14 hnub, mob otitis tawm - txog 10 hnub.

Txog kev tiv thaiv cov kab mob tom qab lub sijhawm ua haujlwm ntev dua 1 teev, ib koob tshuaj 1 g iv yog siv thaum lub sijhawm tshuaj loog. Rau kev ua haujlwm ntev dua - 1 g txhua 6 teev rau ib hnub. Hauv kev pheej hmoo siab ntawm kev kis tus kab mob, kev tswj hwm tuaj yeem txuas ntxiv rau ob peb hnub.

Thaum mob raum tsis ua haujlwm, koob tshuaj thiab ntau npaum li cas tau kho nyob rau CC: rau CC ntau dua 30 ml / min, tsis tas yuav hloov cov tshuaj, rau CC 10-30 ml / min: sab hauv - 250-500 mg / hnub txhua 12 teev, iv - 1 g, tom qab ntawd 500 mg iv, nrog CC ntau dua 10 ml / min - 1 g, tom qab ntawd 500 mg / hnub iv lossis 250-500 mg / hnub ntawm qhov ncauj ib zaug. Rau cov menyuam yaus, qhov tshuaj yuav tsum raug txo kom sib npaug.

Cov neeg mob rau ntawm qhov mob hemodialysis - 250 mg lossis 500 mg ntawm qhov ncauj hauv ib koob lossis 500 mg iv, ntxiv 1 koob tshuaj thaum lub sijhawm lim ntshav thiab lwm 1 koob tshuaj thaum kawg ntawm kev lim ntshav.

Amoxicillin + Clavulanic acid: cov lus qhia rau kev siv

Kev noj tshuaj rau tus kheej tuaj yeem tsim kev phom sij rau koj kev noj qab haus huv.
Nws yog ib qho tsim nyog yuav tsum sab laj tus kws kho mob, nrog rau nyeem cov lus qhia ua ntej siv.

Hmoov rau cov tshuaj rau kev tswj hwm dej khov

0.5 g + 0.1 g, 1.0 g +0.2 g.

Ib fwj muaj

cov tshuaj nquag: amoxicillin sodium hauv amoxicillin - 0.5 g, 1.0 g

poov tshuaj clavulanate nyob rau hauv cov nqe lus ntawm clavulanic acid - 0.1 g, 0.2 g

Hmoov los ntawm dawb dawb mus nrog daj ib zas.

Cov chaw muag tshuaj

Tom qab tso cov tshuaj ntawm cov tshuaj nyob rau hauv koob tshuaj ntawm 1.2 thiab 0.6 g, tus nqi nruab nrab ntawm qhov siab tshaj plaws ntshav plasma concentration (Cmax) ntawm amoxicillin yog 105.4 thiab 32.2 μg / ml, clavulanic acid - 28.5 thiab 10.5 μg / ml, ntsig txog.

Ob qhov sib xyaw ua ke los ntawm cov ntim zoo hauv kev faib tawm hauv lub cev thiab cov nqaij (lub ntsws, nruab nrab pob ntseg, dej pleural thiab peritoneal, lub tsev me nyuam, zes qe menyuam).

Amoxicillin tseem nkag mus rau hauv cov kua ntshav synovial, mob siab, lub caj pas prostate, palatine tonsils, cov leeg nqaij, lub zais zis, lub zais ntawm cov hlab ntshav, zais pa tawm. Amoxicillin thiab clavulanic acid tsis hla cov ntshav-hlwb teeb meem hauv kev tsis txaus ntshai.

Cov khoom muaj zog hla qhov chaw tiv thaiv qhov ncauj thiab nyob rau hauv cov kab mob ntau yog raug nthuav tawm hauv niam cov kua mis.

Kev khi rau cov ntshav plasma protein rau amoxicillin yog 17-20%, rau clavulanic acid - 22-30%.

Ob feem hauv lub siab yog metabolized. Amoxicillin yog qee cov tshuaj tiv thaiv - 10% ntawm kev muab koob tshuaj, clavulanic acid raug kev mob hnyav metabolism - 50% ntawm kev muab koob tshuaj.

Tom qab kev tso tshuaj ntawm cov tshuaj amoxicillin + clavulanic acid nyob rau hauv koob tshuaj ntawm 1.2 thiab 0.6 g, ib nrab-lub neej (T1 / 2) rau amoxicillin yog 0.9 thiab 1.07 teev, rau clavulanic acid 0.9 thiab 1.12 teev.

Amoxicillin ua tawm los ntawm lub raum (50-78% ntawm qhov muab tshuaj) yuav luag tsis hloov pauv los ntawm tubular tso pa tawm thiab glomerular pom. Clavulanic acid yog tawm los ntawm lub raum los ntawm glomerular pom kev hloov pauv tsis txawv, qee qhov ntawm daim ntawv tshuaj metabolites (25-40% ntawm kev muab tshuaj) tsis pub dhau 6 teev tom qab siv tshuaj.

Cov zaub mov me me tuaj yeem tawm ntawm txoj hnyuv thiab lub ntsws.

Cov tshuaj yog ua ke ntawm semisynthetic penicillin amoxicillin thiab beta-lactamase inhibitor - clavulanic acid. Nws ua cov kab mob bactericidal, inhibits kev sib txuas ntawm cov kab mob hauv phab ntsa.

Siv tawm tsam:

Cov kab mob aerobic gram-zoo (nrog rau cov kab mob beta-lactamase ua rau cov leeg nqaij): Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus spp, Corynebacterium spp., Listeria monocyt

anaerobic gram-cov kab mob zoo: Clostridium spp., Peptococcus spp., Peptostreptococcus spp.,

aerobic gram-cov kab mob tsis zoo (nrog rau cov uas tsim cov tshuaj beta-lactamases): Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella spp., Salmonella spp., Shigella spp.

, Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Haemophilus influenzae, Haemophilus ducreyi, Yersinia multocida (yav tas los Pasteurella), jejunl

anaerobic gram-cov kab mob tsis zoo (suav nrog beta-lactamase ua kev lim tawm): Bacteroides spp., suav nrog Bacteroides fragilis.

Clavulanic acid suppresses hom II, III, IV thiab V hom beta-lactamases, tsis muaj zog tiv thaiv hom I beta-lactamases uas ua los ntawm Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

Clavulanic acid muaj lub siab tropism rau penicillinases, vim tias nws tsim cov chaw ruaj khov nrog cov enzyme, uas tiv thaiv qhov enzymatic degradation ntawm amoxicillin nyob rau hauv kev cuam tshuam ntawm beta-lactamases.

Kab mob sib kis thiab mob kis los ntawm cov kab mob me me nkag siab rau cov tshuaj:

- kis mob ntawm cov pa hauv siab (suav nrog rau ENT kabmob):

Mob Siab Tshaj Plaws thiab mob ntsws, mob hlwb thiab mob txha ntev,

pharyngeal abscess, tonsillitis, pharyngitis

- txo qis mob ntsws ua pa: mob ntsws zoo nrog tus kab mob superinfection, mob ntsws txhaws ntev, mob ntsws

- kis kab mob ntawm cov genitourinary system: pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, chancre me me, kab mob gonorrhea

- kev kis mob rau mob gynecology: mob ncauj tsev menyuam, salpingitis, salpingoophoritis, tubo-ovarian paum, endometritis, kab mob vaginitis, septic rho menyuam

- kis kab mob ntawm cov tawv nqaij thiab cov nqaij mos: erysipelas, impetigo, kis tus kab mob thib ob, dermatoses, qog, phlegmon, mob voos

- kis kab mob ntawm cov pob txha thiab cov nqaij mob sib kis

- biliary huam mob: cholecystitis, cholangitis

- cov kab mob odontogenic, tiv thaiv tom qab phais mob, tiv thaiv kev kis kab mob los ntawm cov kab mob tshwm sim hauv kev phais mob ntawm pathologies ntawm lub plab zom mov

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj rau tshuaj yog teem ib lub zuj zus nyob ntawm lub hnub nyoog, lub cev nyhav, lub raum kev ua haujlwm, thiab tseem nyob ntawm qhov mob hnyav sib kis. Txoj kev kho yuav tsum tsis txhob txuas ntxiv rau 14 hnub yam tsis rov ntsuas nws tus mob.

Cov neeg laus thiab cov menyuam muaj hnub nyoog tshaj 12 xyoos: cov tshuaj tau sau tseg nyob rau hauv ib koob ntawm 1.2 g txhua 8 teev 3 zaug hauv ib hnub, yog kis mob hnyav - txhua 6 teev, 4 zaug ib hnub. Qhov tshuaj tiv thaiv qhov ntau tshaj txhua hnub yog 6 g.

Hauv cov menyuam yaus lub cev tsawg dua 40 kg, koob tshuaj yog siv raws qhov hnyav ntawm lub cev. Nws raug nquahu kom muaj kev ncua sijhawm 4-teev nyob nruab nrab ntawm kev txhaj tshuaj ntawm Amoxicillin + Clavulanic acid txhawm rau txhawm rau txhawm rau txhawm rau tiv thaiv ntau dhau ntawm clavulanic acid.

Cov me nyuam qis dua 3 hli

Cov menyuam yaus hnyav dua 4 kg: 50/5 mg / kg txhua 12 teev

Cov menyuam yaus lub cev hnyav dua 4 kg: 50/5 mg / kg txhua 8 teev, nyob ntawm seb muaj mob ntau npaum li cas

Cov menyuam muaj 3 hlis txog 12 xyoos

50 / 5mg / kg txhua 6–8 teev, nyob ntawm seb tus kab mob loj npaum li cas

Rau cov neeg mob uas lub raum tsis txaus, qhov koob tshuaj thiab / lossis qhov luv nruab nrab ntawm kev txhaj tshuaj yuav tsum tau kho raws li cov neeg kawm ntawv ntawm kev tsis txaus: thaum kev tsim tawm muaj peev xwm ntau tshaj 30 ml / min, qhov kev txo koob tshuaj tsis tas, thaum tsim creatinine tshem tawm yog 10-30 ml / min, kev kho mob pib nrog 1.2 g , tom qab ntawd 0.6 g txhua 12 teev, nrog creatinine tshem tawm tsawg dua 10 ml / min - 1.2 g, tom qab ntawd 0.6 g / hnub.

Rau cov menyuam yaus uas muaj qhov creatinine tsawg dua 30 ml / min, kev siv daim foos ntawm Amoxicillin + Clavulanic acid tsis pom zoo.Txij li 85% ntawm cov tshuaj raug tshem tawm los ntawm hemodialysis, qhov kawg ntawm txhua tus txheej txheem hemodialysis, koj yuav tsum nkag mus rau kev siv ib txwm ntawm cov tshuaj.

Nrog peritoneal lim ntshav, kev hloov kho koob tsis tas yuav tsum.

Kev npaj thiab kev coj ua ntawm cov kev daws teeb meem rau kev txhaj tshuaj: yaj tawm cov ntsiab lus ntawm lub vial 0.6 g (0.5 g + 0.1 g) hauv 10 ml dej rau kev txhaj tshuaj lossis 1.2 g (1.0 g + 0.2 g) hauv 20 ml dej rau kev txhaj tshuaj.

Hauv / hauv nkag mus nkag qeeb (hauv 3-4 feeb.)

Kev npaj thiab kev qhia txog kev daws teeb meem rau txoj kev lis ntshav: tau npaj cov tshuaj rau cov tshuaj txhaj uas muaj 0.6 g (0.5 g + 0.1 g) lossis 1.2 g (1.0 g + 0.2 g) ntawm cov tshuaj yuav tsum tau diluted hauv 50 ml lossis 100 ml ntawm kev daws rau Txoj kev lis ntshav, feem. Lub sijhawm ntawm kev lis ntshav yog 30-40 feeb.

Thaum siv cov lus qhia hauv kev lis ntshav hauv qab ntim hauv cov ntawv pom zoo, cov tshuaj tua kab mob tsim nyog yuav tau muab khaws cia hauv lawv.

Raws li kev daws teeb meem rau kev ua haujlwm ntawm qhov dej qab zib, Txoj kev lis ntshav muaj peev xwm siv tau: ib qho kev daws teeb meem ntawm sodium chloride 0.9%, Ringer txoj kev daws teeb meem, kev daws teeb meem ntawm potassium chloride.

Amoxicillin nrog clavulanic acid - kev kho mob tshuaj ntawm soluble cov ntaub ntawv ntawm cov tshuaj tua kab mob

Nrog kev tawm tsam nyob rau hauv Russia ntawm soluble tshuaj tua kab mob xws li amoxicillin clavulanic acid, peb tau txais qhov peb tau tos ntev - qhov tshuaj kho nrog qhov tsis tshua muaj tshwm sim, nrog kev cia siab ntau dua ntawm kev rov zoo.

Lub sijhawm no, yog tias koj saib ntawm daim duab tiag tiag ntawm kev sau cov tshuaj antimicrobial (txuas ntxiv - PL) hauv peb lub teb chaws, nws tuaj yeem raug sau tseg tias, txawm hais tias kev mob siab ua kom tshem tawm qee cov tshuaj tua kab mob los ntawm cov kws kho mob tau siv, qhov xwm txheej tseem nyob deb ntawm qhov zoo tshaj Cov.

Txawm li cas los xij, peb sau tseg txog ib qho kev hloov los ntawm kev siv tshuaj ntau nrog kev ua tau zoo. Yog tias peb tham txog kev kho mob ntsws ua pa, peb tuaj yeem sau cov lus qhia tseem ceeb hauv kev kho peb cov neeg mob - qhov no yog kev tawm tsam Str.pneumoniae, H.influenzae thiab Moraxella catarrbalis.

Xws li cov tshuaj antimicrobial li amoxicillin tuav txoj haujlwm tseem ceeb hauv peb lub tebchaws. Nws qhov kev ua haujlwm siab tiv thaiv beta-hemolytic pawg A streptococci, pneumococci, hemophilic bacillus (tsis tsim cov beta-lactamase) tau lees tias.

Kev npaj ua ke ntawm amoxicillin + clavulanic acid yog tus yam ntxwv ntawm kev muaj peev ntau dua thiab nqus tau ntau dua li ntawm ampicillin, muaj qhov siab ntawm kev nkag mus rau tonsils, maxillary sinuses, nruab nrab pob ntseg kab noj hniav, bronchopulmonary system.

Piv nrog rau cov tshuaj ampicillin trihydrate, amoxicillin nrog clavulanic acid muaj qhov txiaj ntsig zoo - cov roj me me loj, uas ua rau nws nkag mus rau hauv lub microbial cell, ntau dua bioavailability, uas yog ywj siab ntawm kev noj zaub mov, uas yog tshwj xeeb tshaj yog cov cim rau cov tshuaj soluble dos ntawm cov tshuaj no tsim siv cov tshuab Solutab ”(Flemoxin Solutab). High bioavailability nyob rau hauv cov ntaub ntawv ntawm cov tshuaj antimicrobial yog ib qho tseem ceeb tsis tsuas yog nyob rau hauv cov nqe lus ntawm cov nyhuv ntawm cov tshuaj, tab sis kuj hais txog kev pheej hmoo ntawm kev mob plab hnyuv dysbiosis. Tom qab tag nrho, cov tshuaj tua kab mob uas tsis tau nqus rau hauv cov kab mob system yuav nyob rau hauv plab hnyuv lumen, uas ua rau muaj kev muaj peev xwm ntawm dysbiotic lesions thiab raws plab.

Cov ntsiab lus ntawm peb cov kev sib tham yog kev sib xyaw ntawm amoxicillin thiab clavulanic acid hauv cov tshuaj soluble dos (hereinafter - LF).

Nws tsim nyog teev tias kev tsim cov tshuaj soluble tseem cuam tshuam los ntawm qhov pom ntawm kev ua raws: txawm tias qhov tseeb hais tias cov tshuaj ua kua rau cov menyuam yaus, thiab cov khoom siv tshuaj khov (tsiav tshuaj thiab ntsiav tshuaj) yog rau cov laus, ntau tus neeg laus vim kev nyiam tus kheej lossis lwm yam (neeg laus, txaj) tus neeg mob) xav siv cov kua LF. Cov kua tshuaj ib txwm muaj, piv txwv li cov dej cawv, muaj cov kev txwv nyob rau hauv kev ua siab ntev ntawm cov tshuaj cuam tshuam nrog solubility ntawm cov tshuaj nws tus kheej, ncua kev kawm - qhov zoo tshaj ntawm cov tshuaj tua kab mob / stabilizer.Kev daws qhov teeb meem no tau tshwm sim ntawm cov thev naus laus zis "Solutab", nyob rau hauv uas cov tshuaj yeeb dej caw yog muab tso rau hauv microgranules, txhua qhov ntawm cov ntawd yog nrog cov daim nyias nyias uas yaj nyob rau hauv thaj chaw alkaline ntawm txoj hnyuv.

Amoxicillin hauv microspheres tswj kev ruaj khov hauv thaj chaw acidic. Thaum noj cov tshuaj amoxicillin tsis tu ncua, qee qhov nws yaj hauv lub plab, yog li peb poob qee qhov feem pua ​​ntawm cov tshuaj.

Thaum noj, kev sib cais ntawm cov tshuaj tshwm sim nyob rau sab qaum kev ntawm txoj hnyuv, uas ua rau kom nrawm dua, ua kom tiav qhov siab thiab qhov tsawg tshaj plaws tsis zoo ntawm lub plab.

"Solutab" kws kho mob thev naus laus zis ua rau muaj kev noj qab haus huv ntxiv, tsis tsuas yog amoxicillin, tab sis kuj tseem muaj clavulanic acid.

Raws li cov ntaub ntawv hauv daim duab hauv qab no, nws muaj peev xwm txheeb xyuas tau tias cov LFs uas tau tawg lawm muaj qhov zoo dua li cov tshuaj sib txawv, tsis yog hais txog cov tshuaj noj, tab sis kuj ua raws cai: muaj peev xwm noj "cov neeg mob txaj" tsis muaj kev pheej hmoo ntawm "daig" tsiav tshuaj lossis ntsiav tshuaj hauv cov quav ntawm txoj hlab pas, ib LF rau cov neeg laus thiab tus me nyuam, qhov kev xaiv yog kom yaj lub ntsiav tshuaj lossis ua kom tag nrho. Nws yog tsis yooj yim sua kom tsis txhob nco qab cov txiaj ntsig tsawg ntawm Flemoklav Solutab ntawm lub plab hnyuv microflora, uas tau ua los ntawm kev ua kom tsis tshua muaj siab tshaj plaws ntawm cov tshuaj nyob rau hauv cov hnyuv.

Tam sim no, muaj kev nce siab ntawm kev pom ntawm cov kab mob tshwm sim ntawm cov kab mob pathogenic uas ua rau beta-lactamases. Cov enzymes no tsim tau cov tshuaj tua kab mob ntawm txoj hlab ua pa: H.influenzae, Moraxella catarrbalis, E. coli. Kev siv cov tshuaj tiv thaiv-tiv thaiv penicillins yog ib qho ntawm kev cog lus tshaj plaws los mus kov yeej qhov kev cuam tshuam nrog kev tsim cov beta-lactamases.

Cov tshuaj khuam tsis tseem ceeb khi khi rau beta-lactamases (sib hu ua cov nyhuv tua tus kheej) ob qho tib si sab nraum lub cell (hauv cov kab mob gram-zoo) thiab sab hauv nws (hauv gram-negative), thiab muaj peev xwm ua kom cov tshuaj tua kab mob muaj cov nyhuv antimicrobial.

Qhov tshwm sim ntawm kev siv tshuaj tiv thaiv kab mob yog qhov txo qis hauv qhov tsawg kawg nkaus ntawm qhov tshuaj tiv thaiv tsis haum (MIC) ntawm cov tshuaj tua kab mob thiab, yog li ntawd, qhov kev nce ntawm cov tshuaj, uas pom meej meej los ntawm kev sib piv cov kev ua ntawm amoxicillin thiab nws txoj kev sib xyaw nrog clavulanic acid.

Clavulanic acid txhim kho qhov kev txiav txim ntawm cov tshuaj tiv thaiv tsis tsuas yog vim qhov thaiv ntawm cov enzymes, tab sis kuj vim muaj cov nyhuv los tiv thaiv kab mob (txo qis hauv kev tso tawm ntawm cov kab mob me me hauv ib chav ntim), nrog rau cov txiaj ntsig tom qab beta-lactamase-inhibitory tiv thaiv qee cov kab mob.

Lub ntsiab lus ntawm tom kawg yog tias nyob rau hauv kev cuam tshuam ntawm clavulanate, lub microbial cell nres ua cov beta-lactamase ib pliag, uas muab amoxicillin ntxiv "qib ntawm kev ywj pheej". Cov post-beta-lactamase-inhibitory effect tseem tsawg kawg 5 teev.

tom qab cov kua qaub pib ua haujlwm, thiab yog tias lub microbial cell tsis tsim beta-lactamase tsis pub dhau 5 teev, ib txwm muaj, kev ua haujlwm ntawm amoxicillin nce ntxiv.

Amoxicillin xyaw nrog clavulanic acid ua pov thawj muaj txiaj ntsig tseem ceeb ntawm cov nyhuv. Qhov sib ntxiv ntawm beta-lactamase inhibitor tseem tsim cov kev ua los tiv thaiv anaerobic, uas yog qhov tseem ceeb rau kev kho mob sib xyaw sib kis, uas feem ntau pom, piv txwv li, hauv kev tawm suab thiab kev kho mob gynecological.

Cia peb rov qab mus rau lub pharmacokinetics ntawm cov tshuaj hauv cov lus nug. Muaj lub hom phiaj sib txawv ntawm qhov nqus ntawm amoxicillin thiab clavulanic acid vim qhov sib txawv hauv cov kua qaub-puag lub zog ntawm cov tshuaj no.

Amoxicillin yog lub hauv paus tsis muaj zog, thiab clavulanate yog cov kua qaub ua kom tsis muaj zog. Raws li qhov tshwm sim, cov tshuaj no muaj qhov sib txawv kev nqus hluav taws xob sib txawv, thiab cov xwm txheej tau tsim rau qhov ua tsis tiav ntawm clavulanate.

Raws li, muaj qhov sib txawv ntawm lub sijhawm nqus - nqus tau tshwm sim tsis tsuas yog nrog ntau qhov sib txawv, tab sis kuj nyob rau lub zog sib txawv.

Qhov no yog qhov xwm txheej thib ob vim tias clavulanic acid "lags" nrog kev nqus thiab tswj cov tshuaj khib nyiab hauv txoj hnyuv, uas tsim kom muaj qhov ua kom tau qhov tsis zoo ntawm cov kua qaub rau lub plab hnyuv - 20-25% ntawm cov neeg mob tau txais LF ntawm cov tshuaj uas teb rau kev kho mob raws plab, ua rau lawv tsis kam noj tshuaj.

Yuav ua li cas theem sib txawv ntawm kev nqus? Tom qab tag nrho, cov kua qaub ntau ntxiv nyob rau hauv txoj hnyuv, qhov tsawg dua yog nws cov kuab tshuaj lom ua rau lub plab hnyuv mucosa.

Cov kev tsis zoo muaj feem cuam tshuam nrog kev nqus tsis tau ntawm ib qho beta-lactamase inhibitor yog zawv plab, pseudomembranous colitis, xeev siab, thiab cov kev hloov pauv hauv saj.

Lub Solyutab thev naus laus zis los ntawm kev siv daim ntawv microencapsulated tso cai rau koj kom tsis txhob muaj qhov nqus ntawm qhov muaj zog tas li, thaum kev nqus ntawm cov tshuaj tua kab mob nce ntxiv me ntsis (tsuas yog 5%). Thaum siv Flemoklav Solutab, tsawg dua cov kev mob tshwm sim los xav.

Tam sim no, piv txwv li, ib qho kev tshawb fawb tau ua nyob rau hauv Lavxias Lavxias, kev soj ntsuam ua ntej ntawm kev uas pom tias tsis muaj cov kev xav tsis zoo no, uas tau pom rau thawj zaug cuam tshuam nrog amoxicillin / clavulanate, tib lub sijhawm muaj pov thawj ntawm cov kab mob microbiological ntawm kev ua ntawm cov tshuaj no, kev txhim kho thiab rov ua haujlwm.

Tseem muaj qhov sib txawv ntawm cov permeability ntawm qhov sib txawv LF amoxycillini + acidi clavulanici muaj cov tes taw hnyav li molecular. Daim duab piav qhia no qhia tseeb txog kev ua lub zog rau kev npaj tshuaj rau ib txwm muaj cov cev nyhav ntawm 600-800 g / mol txawv ntawm Flemoklav Solutab (200-400 g / mol).

Nws tau pom tias qhov ntau zaus ntawm raws plab thaum nkag mus ncaj qha nyob ntawm kev hloov pauv ntawm clavulanate. Thaum siv cov ntsiav tshuaj zoo li LF amoxicillin nrog clavulanate, suav nrog cov tshuaj qub, nws tsis tuaj yeem kom ua tiav cov teeb meem sib luag thiab kev nqus ntawm cov kua qaub.

Hauv Flemoklav Solutab, peb tau txais qhov txiaj ntsig zoo dua ntxiv: kev sib txawv ntawm qhov nqus ntawm clavulanate los ntawm ib ntsiav tshuaj noj tag nrho lossis yav tas los yaj tsis tseem ceeb.

Nyob rau tib lub sijhawm, peb tuaj yeem soj ntsuam qhov nce ntawm qhov muaj ntau ntawm clavulanate hauv cov ntshav cov ntshav - siv cov LF uas yooj yim, koj tuaj yeem ua tiav qhov kev xav ntawm ntau tshaj li 2 μg / ml, siv Flemoklav - yuav luag 3 μg / ml.

Kev tsim kho niaj hnub hauv thaj chaw ntawm lub tsev muag tshuaj, uas cuam tshuam rau lub zog pharmacokinetic ntawm antimicrobials, tuaj yeem txhim kho cov tshuaj kho cov tshuaj tua kab mob kom zoo ib yam nrog kev txo qis tus naj npawb thiab qhov tsis zoo ntawm cov kev mob tshwm sim.

Cov tshiab soluble LF amoxycillinum / acidum clavulanicum - Flemoklav Solutab - yog qhov tseem ceeb tshiab ntawm qhov ua tau zoo hauv kev siv tshuaj yeeb tshuab.

Kev nqus ntawm acidi clavulanici ntau ntxiv kev tiv thaiv thiab muaj txiaj ntsig ntawm amoxycillini thiab tib lub sijhawm txo cov kev muaj feem ntawm kev cuam tshuam nrog clavulanic acid, tshwj xeeb tshaj yog tom qab tshuaj tua kab mob zawv plab.

LF tshwj xeeb muab kev nce ntxiv rau "kev kho mob chaw muag tshuaj" ntawm cov kab mob ntawm cov kis kab mob, uas ua rau kom muaj kev sib tua ntau dua thiab, vim li ntawd, kev tiv thaiv ntawm cov tshuaj tua kab mob siab nrog kev pheej hmoo ntawm kev tsim cov kab mob tiv thaiv kab mob. Nyob rau tib lub sijhawm, LF "Solyutab" nws yooj yim heev rau ob tus neeg mob laus uas nyiam cov ntsiav tshuaj ncua kev kawm thiab rau menyuam yaus.

Daim ntawv tso tawm, ntim thiab muaj pes tsawg leeg Amoxicillin + Clavulanic acid - Vial

fwj (1) - pob ntawm cardboard.
fwj (10) - pob khoom los ntawm thawv ntawv (12) - thawv ntawv thawv.
fwj (10) - pob khoom los ntawm cardboard (50) - thawv ntawm duab los qhia.
fwj (10) - pob khoom ntawm cardboard (60) - thawv ntawv thawv.

Kev Qhia Txog Amoxicillin + Clavulanic Acid - Vial

Cov kab mob kis tau los ntawm cov tshuaj lom neeg lub cev tsawg:

• kev kis mob ntawm txoj hlab pa hauv qis (exacerbation ntawm mob ntsws, ua rau mob ntsws thiab mob ntsws),
• kev kis mob ntawm cov mob ENT (kev tiv thaiv kab mob otitis, sinusitis, tonsillitis),
• mob txeeb zig (suav nrog cystitis, mob hlab hlwb, pyelonephritis),
• mob ntawm pelvic plab hnyuv siab raum (suav nrog salpingitis, salpingoophoritis, endometritis, septic rho menyuam, pelvioperitonitis, postpartum sepsis),
• kis kab mob ntawm cov tawv nqaij thiab cov nqaij mos (phlegmon, mob voos, erysipelas, impetigo, abscesses),
• kis kab mob ntawm cov pob txha thiab pob qij txha (suav nrog mob txha osteomyelitis),
• kis kab mob sib deev (kab mob gonorrhea, mob sib chwv me me),
• lwm yam kab mob sib kis: septicemia, peritonitis, intraabdominal sepsis, postoperative kis tau.

Kev tiv thaiv kab mob tom qab phais mob thaum phais mob rau txoj hnyuv, plab hnyuv plab hnyuv, mob taub hau thiab caj dab, plawv, raum, mob plab, nrog rau kev cog cov pob txha mos.

Kev noj tshuaj ntxiv

Cov tshuaj siv iv.

Kev noj tshuaj ntau npaum li cas yog nyob ntawm lub hnub nyoog, lub cev qhov hnyav thiab lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub. Qhov siab kawg ntawm kev kho mob yuav yog 14 hnub, tom qab ntawd nws cov hauj lwm zoo thiab kam rau ua yuav tsum tau ntsuas.

Koob tshuaj yog xam raws li cov ntsiab lus ntawm amoxicillin / clavulanic acid.

Cov neeg laus thiab cov menyuam yaus hnub nyoog 12 xyoos nrog lub cev hnyav dua 40 kg

Cov koob tshuaj txheem: 1000 mg / 200 mg txhua 8 teev.

Cov mob hnyav: 1000 mg / 200 mg txhua 4-6 teev.

Kev Tiv Thaiv Kev Kho Mob

Cov kev cuam tshuam ntev dua tsawg dua 1 teev: 1000 mg / 200 mg thaum lub sij hawm inest ntawm lub tshuaj loog

Cov kev cuam tshuam ntev dua li 1 teev: txog 4 koob ntawm 1000 mg / 200 mg rau 24 teev.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov xav tau ntau tshaj ntawm amoxicillin.