Galvus - cov lus qhia rau kev siv, cov lus teb rau cov lus nquag nug txog cov tshuaj

Galvus yog ib tus neeg sawv cev hypoglycemic tsim los tswj glycemia hauv ntshav qab zib hom 2. Qhov pib ua haujlwm tseem ceeb ntawm cov tshuaj yog vildagliptin. Cov tshuaj tau tawm hauv cov qauv hauv cov ntsiav tshuaj. Ob tus kws kho mob thiab ntshav qab zib tau txais cov lus teb zoo los ntawm Galvus.

Nws muaj zog tswj cov metabolism hauv ntawm insulin thiab glucagon. Lub Koom Haum European Antidiabetic Association thov tias Galvus hauv kev kho mob ntshav siab tau qhia kom siv tsuas yog thaum metformin yog contraindicated rau tus neeg mob. Rau cov mob ntshav qab zib insulin-tiv thaiv cov mob ntshav qab zib hom 2, Galvus pab txo cov neeg yug tus naj npawb thiab cov tshuaj insulin txhaj ntau dua.

Cov yam ntxwv ntawm Pharmacological

Cov tshuaj hormones yog hu ua cov tshuaj hormones uas cov hnyuv tsim tawm thaum cov khoom noj nkag mus. Cov tshuaj hormones no yog insulinotropic, ntxias cov kua dej hauv lub zais, vim tias 60% ntawm nws cov khoom yog vim qhov tseeb ntawm cov nyhuv ntawm incretins. Qhov tshwm sim no tau pom hauv 1960, thaum lawv kawm los txiav txim siab qhov tawm ntawm cov tshuaj insulin hauv ntshav.

Glucan-zoo li peptide-1 (GLP-1) yog ib qho muaj npe nrov tshaj plaws, vim tias nws qhov kev kub siab yog txo qis hauv cov ntshav qab zib hom 2. Qhov no tau ua rau nce mus rau cov chav kawm tshiab ntawm cov tshuaj uas tsub ntxiv cov ntsiab lus ntawm cov tshuaj hormones xws li los ntawm kev txhaj tshuaj ntawm cov hluavtaws sib piv ntawm GLP-1 xws li Baeta lossis Victoza lossis los ntawm qhov ncauj txhais tau tias xws li Galvus lossis nws li analogue Januvia. DPP-4 cov tshuaj tiv thaiv tsis tsuas yog ua rau kom cov tshuaj lom ntawm ob hom tshuaj hormones, tab sis kuj tseem tiv thaiv lawv lub ntsej muag.

Leej twg nyiam Galvus

Rau cov ntshav qab zib muaj hom mob thib 2, tshuaj yuav siv tau:

Rau kev kho mob hlwb, ua ke nrog kev noj zaub mov kom tsawg thiab ua kom cov leeg mob txaus,
Hauv kev kho ua ke hauv kev sib txuam nrog metformin, yog tias qhov txiaj ntsig tau los ntawm ib qho kev kho tsis txaus,
Raws li lwm txoj hauv kev rau Galvus zoo li tshuaj raws li metformin thiab vildagliptin,
Raws li ib qho ntxiv rau lwm cov kab mob hypoglycemic, yog tias kev kho mob yav dhau los tsis muaj txiaj ntsig,
Raws li kev kho mob triple nrog insulin thiab metformin, yog tias kev noj zaub mov zoo, tawm dag zog thiab insulin nrog metformin tsis muaj tshuaj txaus.

Cov lus qhia rau kev siv

Qhov ntau thiab tsawg yog txiav txim los ntawm tus kws endocrinologist ib leeg zuj zus, noj mus rau theem tus kab mob thiab kev noj qab haus huv feem ntau ntawm cov ntshav qab zib. Kev siv cov ntsiav tshuaj tsis khi rau kev noj tshais thaum sawv ntxov, lub ntsiab yog haus cov tshuaj nrog dej txaus. Nyob rau hauv muaj qhov tshwm sim tsis pom tshwm sim rau txoj hnyuv plab, nws yog qhov zoo dua los siv tshuaj nrog zaub mov.

Yog tias hom ntshav qab zib hom 2 tau teeb tsa, Galvus tuaj yeem raug muab faib tam sim ntawd. Tsis hais txog ntawm kev kho mob kiag li (kev kho mob lossis kev xav tau tshuaj ntsuab), cov tshuaj noj tau noj tshuaj ntau npaum li 50-100g / hnub. Qhov siab tshaj plaws qhov siab tshaj plaws (100 mg / hnub) yog ntsuas nyob rau hauv theem hnyav ntawm ntshav qab zib. Thaum kho, ua ke nrog lwm cov kab mob hypoglycemic, 100 mg / hnub yog kho.

Ib feem ntawm 50 g / hnub. noj ib zaug, feem ntau sawv ntxov, qhov muab tshuaj ntawm 100 mg yuav tsum tau muab faib ua 2 koob tshuaj - sib npaug, thaum sawv ntxov thiab yav tsaus ntuj. Yog tias qhov tau txais tos ntawm Galvus ploj lawm, cov ntsiav tshuaj yuav tsum noj txhua lub sijhawm, tab sis cov ciam teb dav dav yuav tsum raug pom.

Yog tias nrog cov tshuaj monotherapy 100 mg / hnub tuaj yeem noj, tom qab ntawd nrog cov kev kho mob nyuaj, lawv pib nrog 50 mg / hnub, piv txwv li, nrog metformin: 50 mg / 500 mg, 50 mg / 850 mg, 50 mg / 100 mg.

Nrog cov mob ntshav qab zib tsis tiav, lwm cov tshuaj hypoglycemic (metformin, insulin, sulfonylurea derivatives, thiab lwm yam) tau raug tshaj tawm ntxiv.

Yog tias qhov mob ntshav qab zib hauv lub raum thiab lub siab twb ua haujlwm nrog qhov tsis sib haum, qhov ntau kawg yog txo rau 50 mg / hnub, txij li Galvus raug tawm los ntawm lub raum, tsim ib qho ntxiv rau lub zog ntawm qhov tsis txaus.

Tshaj tsos mob

Yog tias qhov kev cai txhua hnub tsis pub dhau 200 mg / hnub, Galvus cov kab mob ntshav qab zib tau pauv mus yam tsis muaj kev rau txim. Kev noj ntau dhau nrog cov tsos mob tsim nyog yog pom thaum noj ntau tshaj 400 mg / hnub. Feem ntau tshwm sim myalgia (mob leeg), tsawg dua - paresthesia (hauv cov ntawv me thiab transistor), o, kub taub hau, lipase qib nce ob zaug siab dua VGN.

Yog hais tias Galvus cov cai muaj peb zaug (600 mg / hnub), muaj kev pheej hmoo ntawm nqaj o, txhaws thiab nce ntxiv hauv ALT, CPK, myoglobin thiab C-reactive protein. Tag nrho cov ntawv sib tw, zoo li cov tsos mob ploj, ploj thaum Galvus tso tseg.

Galvus: analogues

Raws li lub hauv paus pib nquag, cov tshuaj Vildaglympin thiab Galvus Met yuav zoo ib yam rau Galvus, raws li ATX-4 code, Januvia thiab Onglisa coincide. Cov kev tshawb fawb txog kev siv tshuaj thiab cov neeg mob tshuaj xyuas tau pom tias cov tshuaj no sib hloov tau.

Phiv Txheej Xwm

Kev siv sijhawm ntev ntawm Galvus tuaj yeem txuas nrog cov kev mob tshwm sim:

Mob taub hau thiab poob ntawm kev sib koom tes,
Tsov rog ntawm caj npab thiab txhais ceg,
Dyspeptic mob
Tev, hlwv thiab tawv nqaij ua pob ntawm keeb kwm ua xua,
Ua txhaum ntawm cov lus sib dhos ntawm lub plab hnyuv,
Kev tiv thaiv tsis muaj zog
Ib qho kev rhuav tshem thiab neeg ua haujlwm dhau
Kab mob siab, mob rau leeg thiab lwm yam kab mob ntawm daim siab thiab tus leeg txiav,
Ua daus no thiab o.

Rau leej twg Galvus yog contraindicated

Cov kev txwv tsis pub siv rau Galvus yuav yog tus lej ntawm cov kabmob thiab cov mob.

Kev tsis qaug rau tus neeg ntawm cov tshuaj, kev tsis haum tshuaj,
Renal thiab excretory system ua haujlwm tsis zoo,
Cov xwm txheej ua rau lub raum tsis ua haujlwm ntawm lub raum (ua npaws, kis mob, mob plab, ntuav),
Kev mob plawv thiab leeg ntshav
Cov teeb meem ua pa
Tus kab mob ntshav qab zib ketoacidosis, coma, thiab poj koob yawm txwv, thaum cov ntshav qab zib tau txhais rau hauv insulin,
Cov kab mob lactic acidosis, cov tshuaj lactic acid ntau ntxiv,
Cev xeeb tub thiab lactation
Yam 1 ntshav qab zib
Raug kev tsim txom lossis haus cawv,
Kev noj haus nruj heev nrog cov ntsiab lus ntawm calorie ntawm 1000 Kcal / hnub,
Lub hnub nyoog txwv: txog 18 xyoo, lub cev tshuaj tsis tau kho, tom qab 60 xyoo - nrog kev ceeb toom,
Ua ntej kev ua haujlwm (2 hnub ua ntej thiab tom qab), nyob rau Hmo ua ntej ntawm kev qhia ntawm cov neeg sawv cev sib piv lossis kev ntsuas radiographic,
Ib qho ntawm qhov hnyav contraindications rau Galvus yog lactic acidosis, yog li ntawd, nrog daim siab lossis lub raum tsis ua haujlwm, cov tshuaj tsis raug sau tseg.

Hauv cov neeg mob ntshav qab zib ntawm lub hnub nyoog tiav, kev quav rau metformin yog ua tau, qhov no nce qhov feem pua ntawm cov teeb meem, yog li Galvus yog tsuas yog nyob hauv kev saib xyuas kev kho mob nruj.

Nta ntawm Galvus kho mob ntawm qee pawg ntawm cov ntshav qab zib

Tsis muaj cov ntaub ntawv txaus ntseeg ntawm cov nyhuv ntawm cov tshuaj rau ntawm kev noj qab haus huv ntawm leej niam thiab tus menyuam hauv plab, yog li ntawd, thaum cev xeeb tub nws tsis yog kws kho mob. Kev muaj piam thaj ntau ntxiv hauv ib tus poj niam cev xeeb tub muaj feem ua rau muaj kev pheej hmoo ua mob rau lub cev thiab txawm tias tus menyuam yaus tuag. Ntawm cov ntshav qab zib hauv cov poj niam cev xeeb tub, glycemia feem ntau yog li ib txwm muaj los ntawm insulin.

Cov kev tshawb fawb pom tau tias txawm tias ib koob tshuaj Galvus, tshaj li tus cai los ntawm 200 zaug, tsis tau ua rau muaj kev hloov pauv hauv txoj kev noj qab haus huv ntawm tus poj niam cev xeeb tub lossis tus menyuam hauv plab. Qhov zoo sib xws tau kaw nrog kev siv cov metformin thiab Galvus hauv qhov sib piv ntawm 10: 1.

Cov lus nug txog kev muaj peev xwm ntawm cov tshuaj metabolite tau nkag mus rau niam mis tsis tau kawm, yog li ntawd, nrog kev pub niam mis, Galvus kuj tsis yog kws kho.

Cov kev paub ntawm Galvus kho mob ntshav qab zib cov me nyuam nrog tus mob thib 2 (tus naj npawb ntawm cov neeg mob tau nce nrawm dua hnub no), tshwj xeeb, qhov piv ntawm nws cov hauj lwm zoo thiab tsis zoo, tsis tau kawm txaus.

Yog li, nce ntxiv hauv hom 2 mob ntshav qab zib yog tsim los ntawm lub hnub nyoog 18 xyoo.

Tus mob ntshav qab zib ntawm lub hnub nyoog paub tab (tom qab 60 xyoo) yuav tsum nruj tswj hwm ob qho tshuaj ntawm Galvus thiab lawv qhov tseem ceeb, yog li yog tias koj qhov mob ntxiv, qhia rau tus kws kho mob tam sim ntawd. Thaum lub hnub nyoog no, txoj kev pheej hmoo ntawm cov teeb meem thiab qhov tsis xav tau nce ntxiv, vim tias qhov cuam tshuam ntxiv tau pib.

Cov lus pom zoo tshwj xeeb

Tus neeg mob ntshav qab zib yuav tsum tau qhia txog txhua yam yuav tshwm sim los ntawm kev kho mob tshiab rau nws.

Galvus yog ib qho tshuaj tiv thaiv kab mob, tab sis nws tsis yog ib qho tshuaj noj ntawm cov tshuaj insulin. Yog li, nws qhov kev siv yuav tsum muaj kev saib xyuas lub siab ua haujlwm tas li. Qhov no tuaj yeem piav qhia los ntawm qhov tseeb tias lub ntsiab tseem ceeb ntawm Galvus txhim kho cov haujlwm ntawm aminotransferases. Sab nraud, qhov no tsis tau hais tawm hauv cov tsos mob tshwj xeeb, tab sis kev hloov pauv ntawm lub xeev kev ua haujlwm ntawm daim siab mus txog rau kev loj hlob ntawm daim siab yog yam tsis tuaj yeem. Nyob rau hauv txhua rooj plaub, mob ntshav qab zib ua haujlwm pab dawb los ntawm pab pawg tswj tau pom cia li qhov tshwm sim. Nyob rau ntawm thawj cov tsos mob ntawm tus mob pancreatitis (txuas ntxiv mob plab hauv siab), cov tshuaj yuav tsum tau muab tshem tawm sai. Txawm tias tom qab kev kho mob ntawm daim siab mob, Galvus tsis tau hais dua ntxiv.

Cov kws kho ntshav qab zib Insulin-tiv thaiv nrog hom 2 Tus kab mob Galvus tsuas yog ua ke nrog kev npaj tshuaj insulin.

Nquag muaj kev ntxhov siab thiab tshee sai dhau txo qhov ua haujlwm ntawm Galvus. Raws li cov neeg mob ntshav qab zib, feem ntau feem ntau lawv lub cev muaj kev cuam tshuam nrog kev ua kom tsis muaj kev sib koom tes thiab xeev siab. Yog li, kev tsav tsheb los yog ua haujlwm tsis muaj xwm txheej nyob rau hauv cov xwm txheej zoo li no tsis tau pom zoo.

Ua ntej kev kuaj mob ntawm ib hom, Galvus thiab nws cov analogues tau nres rau ob hnub. Cov tshuaj sib piv siv hauv kev kuaj mob feem ntau muaj iodine. Sib cuag vildagliptin, nws tsim kev thauj khoom ntxiv rau lub siab thiab tso rau lub cev. Tawm tsam keeb kwm ntawm qhov tsis zoo hauv lawv qhov kev ua tau zoo, cov kab mob lactic acidosis yuav tshwm sim.

Thawj chav kawm ntawm lub plawv tsis ua haujlwm (NYHA kev faib tawm) nrog cov leeg pob txheem tsis xav tau koob tshuaj kho Galvus. Chav kawm thib ob suav nrog kev txwv cov leeg ua si kom tiv thaiv ua pa luv, ua tsis taus pa thiab tachycardia, vim tias nyob hauv lub xeev tsis muaj xwm txheej tsis muaj qhov mob zoo ib yam.

Txhawm rau kom tsis txhob muaj kev phom sij ntawm lub qog ntshav qab zib, nrog kev sib koom ua ke nrog kev kho mob sulfonylurea, cov tshuaj tiv thaiv kab mob tsawg kawg nkaus yog xaiv.

Qhia Txog Tshuaj Yeeb

Hauv txoj kev kho mob nyuaj nrog ntxiv ntawm metformin, glibenclamide, pioglitazone, ramipril, amlodipine, digoxin, valsartan, simvastatin, warfarin mus rau Galvus, tsis muaj qhov tseem ceeb hauv kev kho mob tau tshwm sim los ntawm lawv cov kev cuam tshuam.

Kev sib koom tes nrog cov thiazides, glucocorticosteroids, sympathomimetics, cov thyroid hormones txo qis hypoglycemic muaj peev xwm ntawm vildagliptin.

Cov tshuaj tiv thaiv ntawm angiotensin-hloov mus rau enzyme nrog kev siv thaum sib luag nce cov kev pheej hmoo ntawm angioedema.

Galvus nrog cov tsos mob zoo li no tsis tso tseg, txij li thaum edema hla nws tus kheej.

Cov tshuaj tsis hloov pauv ntawm cov metabolism hauv cov tshuaj nrog rau cov tib neeg siv cov enzymes CYP3A4, CYP1A2, CYP2C8, CYP3A5, CYP2C9, CYP2C19, CYP2D6, CYP2E1.

Cov cai cia

Hauv cov khw muag tshuaj network, Galvus yog muag los ntawm cov tshuaj noj. Lawv tuaj yeem paub qhov txawv ntawm ib qho beveled ntug thiab ob-sided npav: abbreviations FB thiab NVR. Ntawm lub phaj tuaj yeem yog 7 lossis 14 ntsiav tshuaj ntawm 50 mg. Hauv cardboard ntim muaj los ntawm ob txog kaum ob lub hlwv.

Qhov muab tshuaj yog khaws cia rau hauv qhov kub txog 30 ° C hauv qhov chaw tsaus, tsis muaj nkag rau cov menyuam yaus. Txee lub neej ntawm Galvus txog li 3 xyoos. Cov ntsiav tshuaj uas tas sij hawm yuav tsum muab pov tseg.

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob

Tus neeg sawv cev rau tus mob ntshav qab zib ntau qhov ncauj yog feem ntau tau sau tseg ua ntej rau cov neeg mob ntshav qab zib tam sim ntawd tom qab kuaj mob. Yog li, hauv kev txheeb xyuas ntawm cov ntsiab lus sib tham muaj ntau cov lus nug rau tus kws kho qhov mob endocrinologist tshaj li cov lus teb

Tawm tswv yim txog cov lus ceeb toom no, cov kws kho mob tau hais tias mob ntshav qab zib yog qhov muaj sia nyob ntev heev. Tsis yog Galvus, lossis lwm tus neeg sawv cev rau cov tshuaj tua kab mob tuaj yeem kho qhov ntsuas dej qabzib nyob ntawm tus lej nyob mus ib txhis. Kev noj qab haus huv ntawm tus mob ntshav qab zib yog tas li txuas ntxiv mus, qhov feem pua ntawm cov kev hloov pauv ncaj qha nyob ntawm cov neeg mob ntshav qab zib. Tsis muaj ib yam txuj ci tseem ceeb rau cov neeg mob ntshav qab zib. Tsuas yog kho cov khoom noj khoom haus, kev tsim kho dua tshiab ntawm tag nrho kev ua neej nrog kev kho kho tuaj yeem ua rau qeeb kev loj hlob ntawm cov teeb meem thiab tswj lub neej muaj ntshav qab zib muaj ntshav qab zib nyob rau hauv ib qib.

Tsis yog txhua tus so haujlwm tau txais Galvus ntawm tus nqi ntawm 800 rubles. rau 28 pcs., yog li ntau tau nrhiav qhov hloov rau nws, txawm hais tias Januvia (1400 rubles) lossis Onglisa (1700 rubles) kuj tsis haum rau txhua tus. Thiab cov neeg uas txuas ntxiv siv tsab ntawv ceeb toom tias maj mam qab zib qab zib kom pib tawm ntawm txoj kev tswj hwm thiab qhov ua tau zoo ntawm kev kho mob txo qis.

Pharmacodynamics thiab pharmacokinetics

Caj Yeeb vildagliptin yog lub zog tsim ntawm cov islet apparatus ntawm lub txiav, muaj peev xwm xaiv yam inhibiting enzyme dipeptidyl peptidase-4. Qhov tseem ceeb ntawm cov txheej txheem no nce lub hauv paus pib thiab zaub mov-zais pa tawm ntawm cov hom 1 glucagon-zoo li peptide thiab glucose-cuam tshuam insulinotropic polypeptide los ntawm cov hnyuv mus rau hauv cov kab ke. Qhov no nce qhov kev tsuam ntxiv ntawm cov feem no thiab kev nkag siab ntawm pancreatic cells-hlwb rau cov piam thaj, uas ua kom cov piam thaj tsis muaj qab hau tshuaj insulin

Kev nce qib ntawm glucagon-zoo li peptide ntawm yam thib 1 tuaj yeem ua rau qeeb qeeb ntawm lub plab zom mov, tab sis nrog kev khovildagliptin tsis muaj zoo li ntawd tau sau tseg.

Kev kho mob ntshav qab zib nrog Galvus lossis ua ke nrog metformin, thiazolidinedionederivatives sulfonylureas lossis tshuaj insulin rau lub sijhawm ntev txo qis dua qhov uas muaj glycated hemoglobin thiab piam thaj ntshav. Ntxiv thiab, xws li kev kho mob minimizes qhov tshwm sim ntawm ntshav qog.

Kev nqus tau nqus vildagliptin mus nrawm txaus. Lub peev xwm tsis pub tiag tiag ntawm 85%. Qhov kub siab ntawm cov nquag ua haujlwm hauv cov ntshav yog nyob ntawm cov kws kho mob tau siv.

Tom qab noj cov tshuaj rau ntawm lub plab khoob, nws muaj nyob hauv ntshav cov ntshav tau pom tom qab 1 h 45 min. Noj mov muaj qhov tsis lees paub cov nyhuv ntawm cov tshuaj. Sab hauv lub cev, ntu tseem ceeb ntawm Galvus hloov dua siab tshiab rau hauv metabolitesKev tshem tawm ntawm uas yog tsuas yog nqa tawm siv lub raum.

Kev ntsuas rau siv

Qhov taw qhia tseem ceeb rau kev teem caij Galvus yog kev kho mob mob ntshav qab zib mellitushom 2 hauv mono - lossis ntau hom kev sib xyaw ua ke, piv txwv li, nrog Metformin, Thiazolidinedione derivatives sulfonylureas lossis insulin hauv kev hloov pauv uas tsim los ntawm tus kws kho mob uas koom nrog.

Cov Yuav Tsum Muaj

Cov tshuaj no tsis pom zoo siv nrog:

rhiab rhiab rau vildagliptin thiab lwm yam tshuaj ntawm cov tshuaj,
roj ntsha galactose intolerance, lactase tsis muaj peev xwmpiam thaj galactose malabsorption,
qee zaum muaj mob ntev lub plawv tsis ua hauj lwm
tsis tau muaj hnub nyoog 18 xyoo.

Nrog kev ceev faj, kev kho mob yog kho rau cov neeg mob uas ua rau lub siab ua haujlwm hnyav thiab lub raum tsis ua hauj lwm.

Sab sij huam

Feem ntau, nrog kev kho nrog Galvus, tsis muaj qhov tshwm sim tsis zoo tshwm sim uas yuav tsum tsis ua txuas ntxiv ntawm cov tshuaj.

Txawm li cas los xij, kev txhim kho kev ua xua, tshwj xeeb tshaj yog nyob rau hauv daim ntawv ntawm o, yuav tsum tsis txhob kav tawm. Tej zaum muaj kev ua txhaum ntawm lub siab, kev hloov pauv hauv qhov ntsuas ntawm cov kev ua haujlwm ib txwm muaj ntawm no. Qhov ntxim nyiam ntawm qhov tshwm sim hypoglycemia, mob taub hau, kiv taub hau,lub plab zom mov thiab qhov teeb meem dav dav ntawm lub cev.

Cov lus qhia rau Galvus (Txujci thiab ntau npaum li cas)

Cov tshuaj no yog npaj rau lub qhov ncauj thiab tsis nyob ntawm kev siv khoom noj. Cov tshuaj ntawm cov tshuaj yog xaiv ntawm tus kheej, noj mus rau hauv tus account qhov ua tau zoo thiab cov yam ntxwv ntawm lub cev.

Raws li cov lus qhia rau kev siv Galvus, thaum lub sij hawm monotherapy, zoo li nyob rau hauv ob lub sib xyaw ua ke kev kho nrog thiazolidinedione, metformin lossis tshuaj insulin sau ntawv rau ib koob tshuaj txhua hnub ntawm 50-100 mg. Hauv cov neeg mob hnyav mob ntshav qab zib mellitushom 2txais tshuaj insulin, cov tshuaj txhua hnub ntawm Galvus ntsiav tshuaj yog 100 mg.

Lub hom phiaj ntawm txoj kev kho ua ke peb zaug, uas yog: vildagliptin + metformin+ sulfonylurea derivatives koom nrog kev noj 100 mg ib hnub. Hauv qhov no, feem ntau noj 50 mg - thaum sawv ntxov thiab yav tsaus ntuj.

Ob qho kev sib xyaw ua ke nrog kev kho nrog sulfonylureas suav nrog qhov tshuaj rau txhua hnub ntawm 50 mg ntawm Galvus, uas yog noj thaum sawv ntxov. Nws yog tau nce qhov koob tshuaj txhua hnub rau 100 mg, tab sis feem ntau qhov no tsis xav tau.

Yog tias muaj qhov tsis txaus ntseeg siv thaum muaj kev siv tshuaj ntau tshaj txhua hnub ntawm 100 mg, tom qab ntawd txhawm rau tswj hwm kev txhim kho glycemia ntxiv rau, koj tuaj yeem siv lwm tus neeg sawv cev hypoglycemic, piv txwv li: metformin, thiazolidinedione, sulfonylurea derivativeslossistshuaj insulin.

Noj ntau dhau

Raws li txoj cai, cov neeg mob zam rau Galvus zoo thaum sau tshuaj rau ib hnub noj tshuaj ntau npaum li 200 mg.

Nrog kev teem sijhawm ntawm ib koob tshuaj txhua hnub ntawm 400 mg, kev tsim kho muaj peev xwm ua tau mob taub hau kub taub hauo thiab lwm cov tsos mob uas tsis xav tau.

Kev nce ntxiv ntawm qhov koob tshuaj txhua hnub rau 600 mg tuaj yeem ua rau qhov kev txhim kho ntawm o tuaj, qhov nce ntawm qhov nce ntawm ALT, CPK, C-reactive protein thiab myoglobinCov. Feem ntau, tom qab tsum tsis noj cov tshuaj, tag nrho cov tsos mob ntawm kev noj haus dhau yog tshem tawm.

Kev sib txuam

Nws yog tsim los qhia tias Galvus yog tus yam ntxwv tsis tshua muaj rau kev cuam tshuam nrog tshuaj yeeb. Yog li ntawd, nws raug tso cai kom coj nws ib txhij nrog substrates, inhibitors, inductors cytochrome P450 thiab ntau yam cov enzymes.

Tej zaum muaj kev cuam tshuam tseem ceeb ntawm cov tshuaj no nrog cov tshuaj kuj tau hais tseg rau ntshav qab zib hom 2Piv txwv: Glibenclamide, Metformin, PioglitazoneCov. Cov txiaj ntsig ntawm kev sib txig nrog kev siv tshuaj uas muaj qhov nqaim kho ntau -Amlodipine, Digoxin, Ramipril, Simvastatin, Valsartan, Warfarin tsis teeb tsa, yog li ntawd, kev sib koom ua ke yuav tsum tau ua nrog ceev faj.

Yuav xaiv dab tsi: Galvus lossis Galvus Met? Dab tsi yog qhov txawv?

Galvus yog cov tshuaj raws vildagliptin, thiab Galvus Met yog cov tshuaj sib txuam ua ke uas ntxiv nrog metformin. Ua ke nrog cov metformin, vildagliptin ntau dua txo cov ntshav qab zib. Txawm li cas los xij, nws tsuas yog siv tau yog tias tus neeg mob tsis muaj contraindications rau noj cov tshuaj metformin. Cov kev mob tshwm sim tsis zoo ntawm cov tshuaj no yog: zawv plab, mob plab thiab lwm yam kev cuam tshuam ntawm lub plab zom mov. Tsis txhob tsum kho tam sim ntawd. Raws li txoj cai, cov kev tsis txaus siab no tsuas yog tshwm sim thaum ntxov thaum pib ntawm txoj kev kho, thiab tom qab ntawd lawv dhau los.

Dab tsi los xaiv Galvus Met lossis Yanumet?

Yanumet thiab Galvus Met yog ob qho tshuaj uas muaj kev cuam tshuam zoo ib yam. Ob qho tib si raug tsim los txo cov ntshav qab zib kom tsawg. Txij ntawm lub sijhawm no, nws tsis tuaj yeem teb qhov tshuaj twg zoo dua, vim tias tsis muaj kev tshawb fawb tau tshawb fawb txog cov ncauj lus no.

Tus nqi ntawm cov tshuaj yog tib yam. Koj yuav tsum tau them ntau dua rau kev ntim Yanumet, tab sis cov naj npawb ntawm cov ntsiav tshuaj hauv nws kuj yuav ntau dua.

Ob Galvus Met thiab Yanumet muaj kev tiv thaiv patent, lawv tsis tshua muaj kev phiv thiab yog cov tshuaj nyab xeeb. Koj tuaj yeem pom cov kev txheeb xyuas zoo txog ob qho tib si thiab lwm cov tshuaj.

Galvus lossis metformin - dab tsi los xaiv?

Hauv cov tshuaj Galvus Met, vildagliptin ua yeeb yam tseem ceeb, metformin yog ib qho kev tivthaiv kev pabcuam. Muaj kev xav tias qhov txo qis hauv ntshav qab zib tshwm sim muaj txiaj ntsig vim qhov cuam tshuam ua tau zoo ntawm ob yam no.

Txawm hais tias Galvus Met yog kim dua li cov tshuaj raws li tsuas yog ib qho metformin, nws ua nws txoj haujlwm zoo dua. Yog li ntawd, yog tias cov khoom siv ntawm tus neeg mob tso cai rau nws siv tshuaj yeeb-tshuaj rau kev kho, ces nws yog qhov zoo dua los muab kev nyiam rau nws. Yog tias qhov no ua tsis tau, tom qab ntawd koj yuav tsum xaiv rau kev npaj tshuaj metformin (Glucofage lossis Siofor). Nws yog tsim nyog sau cia tias ob qho Glucofage thiab Siofor yog siv tshuaj yeeb tshuaj. Koj tseem tuaj yeem yuav lawv cov pheej ywg pheej yig uas tsim nyob hauv Russia, tab sis yuav tsis muaj ntau qhov sib txawv ntawm tus nqi.

Raws li rau cov tshuaj Galvus, nws tsis tuaj yeem raug hu ua lub zog tshaj plaws los txo cov ntshav qab zib. Galvus Met rau kev kho mob ntshav qab zib yog qhov zoo tshaj plaws los siv. Galvus yog tau sau tseg tsuas yog tias tus neeg mob tau contraindications rau noj cov tshuaj metformin. Yog tias kev kho mob tsis coj qhov tshwm sim xav tau, tom qab ntawd yuav tsum pib kho cov tshuaj insulin.

Cov yam ntxwv ntawm cov tshuaj Galvus Met

Txhawm rau kom tsis txhob kem plab hauv daim ntawv ntawm kev zawv plab thiab flatulence, nws yog qhov yuav tsum tau coj Galvus Met kom raug. Qhov pib koob tshuaj yuav tsum muaj tsawg heev, nce nws kom zoo. Cov txheej txheem kev kho mob no ua rau lub cev yoog thiab yooj yim nqus cov tshuaj tshiab rau nws. Nws yog metformin uas ua kom mob plab zom mov, tsis yog vildagliptin.

Yuav tiv thaiv cov mob tshwm sim li cas?

Txhawm rau tiv thaiv qhov tshwm sim ntawm kev mob tshwm sim, koj yuav tsum pib kho nrog kev txhaj tshuaj me me ntawm cov tshuaj. Nws raug nquahu kom yuav ib pob ntawm Galvus Met ntsiav tshuaj nrog ntau npaum ntawm 50 + 500 mg thiab noj 1 lub tshuaj ib hnub ib zaug. Yog hais tias lub cev teb tau zoo rau kev kho mob, tom qab ntawd ib lub lis piam lossis 10 hnub, koj yuav tsum noj 2 lub tshuaj ntawm cov tshuaj - thaum sawv ntxov thiab ua ntej yuav mus pw. Thaum lub ntim tiav lawm, koj yuav tsum tau yuav ib cov tshuaj nrog qhov tshuaj ntawm 50 + 850 mg. Siv cov tshuaj no 2 zaug ib hnub. Qhov theem peb ntawm kev kho yog hloov mus rau ib cov tshuaj nrog qhov ntau npaum ntawm 50 + 1000 mg. Cov ntsiav tshuaj kuj haus cawv 2 zaug hauv ib hnub. Cov tshuaj txhua hnub kawg ntawm cov tshuaj yog 100 mg ntawm vildagliptin thiab 2000 mg ntawm metformin.

Yog tias, ntxiv rau cov ntshav qab zib, tus neeg mob tau kuaj pom tias kev rog dhau, ces niaj hnub noj tshuaj metformin tuaj yeem nce ntxiv txog 3000 mg. Rau qhov no, nruab nrab ntawm ib hnub, thaum noj mov, tus neeg mob yuav tau ntxiv tshuaj metformin hauv qhov ntau npaum 850 lossis 1000 mg. Koj tuaj yeem siv cov tshuaj Glucofage lossis Siofor rau qhov no. Qhov no tuaj yeem ua rau qee qhov tsis yooj yim rau ib tus neeg, vim tias siv ib cov tshuaj nws yuav tsum tau noj ob yam tshuaj sib txawv. Txawm li cas los xij, kom txo qis tshaj qhov hnyav yuav tau tuaj rau qhov teeb meem nrog qhov tseeb no.

Galvus Met yog qaug cawv thaum noj mov, qhov no yog vim muaj cov ntsiab lus ntawm metformin hauv nws. Hauv cov tshuaj, Galvus metformin tsis yog, yog li ntawd, nws tuaj yeem noj ob qho tib si ua ntej noj mov thiab tom qab noj mov. Nws tsis muaj nqi.

Galvus yuav luag 2 zaug pheej yig dua li Galvus Met. Yog tias koj xav txuag, tom qab ntawd koj tuaj yeem yuav cov tshuaj Galvus thiab cov tshuaj metformin cais (Glucofage lossis Siofor). Txawm li cas los xij, koj yuav tsum ua raws li txhua qhov kev pom zoo rau kev noj cov tshuaj no, uas yuav tsum muaj kev qhuab qhia ntau dua ntawm cov neeg mob.

Yog tias tus neeg mob tau nce siab hauv cov ntshav qab zib kom meej meej thaum sawv ntxov, tom qab ntawd koj yuav tsum noj 1 lub tshuaj ntawm Galvus thaum sawv ntxov thiab yav tsaus ntuj, thiab ua ntej mus pw, ntxiv rau haus cov tshuaj raws li metformin, nrog tshuaj ntau dua 2000 mg (Glucofage Ntev). Nws lub sijhawm ntev dhau los tso cai rau peb kom ntseeg tau tias thaum sawv ntxov cov suab thaj tsis nce siab mus rau qib tseem ceeb.

Kuv puas tuaj yeem haus cawv?

Tom qab kawm cov lus qhia, koj yuav tsis nkag siab tias haus dej cawv puas tso cai thaum kho nrog Galvus thiab Galvus Met. Kev haus dej haus cawv ntau yog txwv kom meej meej, vim tias qhov no yuav ua rau muaj kev puas siab ntsws, muaj mob rau daim siab, txo cov ntshav qab zib kom tsawg. Ib tug neeg yuav mus nyob hauv tsev kho mob lossis tuag taus.

Txog ntawm cov cawv me me, tsis muaj ib qho meej meej tag. Cov lus qhia tsis cia ncaj qha los yog txwv tsis pub cov tshuaj sib xyaw nrog cawv. Yog li ntawd, ib tug neeg tuaj yeem haus, tab sis tsuas yog ntawm koj tus kheej txoj kev phom sij thiab kev pheej hmoo. Yog tias tom qab haus cawv muaj peev xwm tswj hwm tus kheej ploj, ces koj yuav tsum tso tseg nws txoj kev haus dej haus cawv.

Kuv tuaj yeem yuag tawm thaum kho mob?

Cov kev tshawb fawb ntawm cov ncauj lus no qhia tias Galvus thiab Galvus Met tsis cuam tshuam rau lub cev qhov hnyav. Txawm li cas los xij, raws li kev coj ua tiag tiag nrog kev siv cov metformin qhia, nws tseem muaj peev xwm los tua rog rog. Yog li ntawd, qhov ntxim nyiam uas tus neeg mob yuav poob ceeb thawj tseem nyob siab.

Yuav hloov cov tshuaj Galvus Met li cas?

Cov xwm txheej uas Galvus Met yuav xav kom hloov:

Cov tshuaj tsis txo cov ntshav qab zib hauv cov ntshav, uas khaws cia hauv theem siab.

Cov tshuaj txo cov ntshav qab zib, tab sis nws qib tsis txo qis dua 6 mmol / l.

Ib tug neeg tsis tuaj yeem them nyiaj txuas mus ntxiv nrog cov tshuaj no vim yog peev nyiaj txiag.

Yog tias Galvus Met tsis ua haujlwm, ces qhov no tuaj yeem tsuas yog tshwm sim los ntawm qhov tseeb tias cov peev txheej ntawm tus txiav ua tiav tag nrho. Hauv qhov xwm txheej no, tsis muaj lwm yam tshuaj yuav pab, tus neeg mob xav tau cov tshuaj insulin sai. Txwv tsis pub, nws yuav sai sai no tsim cov kev mob hnyav ntawm tus mob.

Nquag, cov piam thaj hauv ntshav yuav tsum tsis pub tshaj 5.5 mmol / L. Cov kev tsim nuj no yuav tsum nyob ruaj khov thiab tsis hloov thaum nruab hnub. Yog tias noj Galvus Met tso cai rau koj nqa cov ntshav qab zib kom txog qib ntawm 6,5-8 mmol / l, tom qab ntawd koj yuav tsum txuas cov tshuaj insulin hauv kev txhaj tshuaj me. Cov txheej txheem yog xaiv raws li tus neeg cov yam ntxwv ntawm kev muaj mob ntshav qab zib hauv ib tus neeg mob. Tsis tas li, tus neeg mob yuav tsum ua raws kev noj haus thiab tawm dag zog. Ib tus neeg yuav tsum nkag siab tias nrog ntshav qab zib hauv 6.0 mmol / L, cov kab mob sib kis txuas ntxiv mus, tab sis ntawm kev qeeb qeeb.

Yog tias tsis muaj txoj hauv kev yuav cov tshuaj Galvus Met?

Yog tias Galvus thiab Galvus Met tshuaj yuav kim rau tus neeg mob, thiab nws tsis tuaj yeem yuav lawv, koj yuav tsum siv tshuaj metformin rau hauv nws daim ntawv purest. Qhov no tej zaum yuav tau txais cov tshuaj Glucofage lossis Siofor. Lawv tau ua txawv teb chaws. Lawv cov Lavxias teb sab koom nrog txawm tias txawm pheej yig dua.

Nco ntsoov tias ua raws li kev noj zaub mov kom tsawg-carb. Txwv tsis pub, tus kabmob no yuav vam meej tuaj.

Hais txog tus kws kho mob: Txij xyoo 2010 txog 2016 Tus kws kho mob kho mob hauv tsev kho mob ntawm lub hauv paus chav noj qab haus huv naj npawb 21, lub nroog ntawm elektrostal. Txij li xyoo 2016, nws tau ua haujlwm hauv chaw kuaj mob tus lej 3.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage form - ntsiav tshuaj: los ntawm lub teeb daj mus rau dawb, puag ncig, nrog cov ntug beveled, nrog rau qhov chaw du thiab NVR luam tawm ntawm ib sab, FB - nyob rau lwm qhov (7 pcs. Los yog 14 pcs. Hauv pob blister, hauv ib lub thawv ntawv) , 4, 8 lossis 12 lub hlwv thiab cov lus qhia rau kev siv Galvus).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: vildagliptin - 50 mg,
Lub cev ntu: sodium carboxymethyl hmoov txhuv nplej siab, anhydrous lactose, microcrystalline cellulose, magnesium stearate.

Cov Tshuaj Pharmacokinetics

Vildagliptin thaum noj ntawm qhov ncauj ntawm lub plab khoob sai sai, C_max (qhov siab tshaj plaws ntawm ib yam khoom) nyob rau hauv cov ntshav ntshav tau mus txog hauv 1.75 teev. Thaum muaj kev sib xyaw nrog kev noj zaub mov, tus nqi ntawm kev nqus ntawm vildagliptin tsawg dua: qhov txo qis hauv C_max los ntawm 19%, thaum lub sijhawm ua kom tiav nws nce li ntawm 2.5 teev. Txawm li cas los xij, kev noj zaub mov nyob rau qib ntawm kev nqus thiab AUC (thaj chaw hauv qab nkhaus "concentration - sijhawm") tsis muaj kev cuam tshuam.

Vildagliptin yog nqus tau sai, thiab nws qhov tseeb txog kev txheeb tsis taus yog 85%. C qhov tseem ceeb_max thiab AUC hauv kev kho mob ntau ntxiv nce ntxiv kwv yees qhov sib npaug ntawm cov koob tshuaj.

Cov tshuaj yog tus cwj pwm ntawm cov neeg tsis muaj kev khi ntawm cov ntshav plasma protein (ntawm qib 9.3%). Vildagliptin tau muab faib ncaj nruab nrab ntawm cov ntshav liab thiab ntshav ntshav. Kev faib tawm cov khoom tshwm sim, txawm tias, raug mob ntxiv, V_ss (qhov ntim ntawm kev faib tawm hauv qhov sib npaug) tom qab kev tswj hwm dej yog 71 litres.

Qhov tseem ceeb ntawm kev tshem tawm vildagliptin yog biotransformation, uas yog nthuav tawm rau 69% ntawm koob tshuaj. Lub ntsiab tshuaj tivthaiv yog LAY151 (57% ntawm koob tshuaj). Nws tsis ua rau pom kev ua lag luam pharmacological thiab yog cov khoom ntawm hydrolysis ntawm cyano tivthaiv. Txog li 4% ntawm cov koob tshuaj tiv thaiv amide hydrolysis.

Thaum lub sij hawm kawm preclinical, ib qho txiaj ntsig zoo ntawm DPP-4 ntawm hydrolysis ntawm vildagliptin tau tsim. Hauv cov metabolism hauv ib yam khoom, cytochrome P isoenzymes₄₅₀ tsis txhob koom nrog. Vildagliptin substrate isoenzyme P₄₅₀ (CYP) tsis yog, cytochrome P isoenzymes₄₅₀ tsis inhibit thiab tsis ntxias.

Tom qab noj cov vildagliptin sab hauv, kwv yees li 85% ntawm cov koob tshuaj yog tawm los ntawm lub raum, los ntawm txoj hnyuv - thaj tsam li 15%. Cov quav tsis ntxiv ntawm cov tshuaj tsis hloov pauv yog 23%. Nruab Nrab T_1/2 (ib nrab-lub neej) thaum muab cov khoom siv dej khov yog 2 teev, lub raum ntxuav thiab tag nrho cov ntshav ua kom huv ntawm vildagliptin yog 13 thiab 41 l / h, feem. T_1/2 tom qab lub qhov ncauj tswj hwm, tsis hais txog ntawm qhov koob tshuaj, yog li 3 teev.

Pharmacokinetic nta hauv cov neeg mob uas lub siab ua tsis tau zoo:

mob hnyav thiab mob hnyav (6–9 ntsiab lus ntawm Child-Pugh nplai): tom qab siv ib leeg vildagliptin, nws txoj kev noj qab haus huv raug txo qis li 20% thiab 8%, feem,
mob hnyav (10-12 cov ntsiab lus ntawm Me-Pugh nplai): kev siv tsis tau ntawm vildagliptin nce ntxiv txog 22%.

Cov kev hloov pauv (nce lossis txo qis) hauv qhov siab tshaj plaws ntawm qhov khoom ntawd tshaj li 30% yog suav tias yog kev kho mob tseem ceeb. Tsis muaj kev cuam tshuam rau ntawm nruab nrab ntawm kev txiav txim plaub ntawm vildagliptin thiab qhov hnyav ntawm lub siab ua haujlwm tsis zoo.

Pharmacokinetic cov yam ntxwv hauv cov neeg mob uas lub raum tsis ua haujlwm tsis muaj qhov txawv, qib nruab nrab lossis mob hnyav (hauv kev sib piv nrog cov neeg pab dawb):

AUC ntawm vildagliptin: nce 1.4, 1.7 thiab 2 zaug, ua ntu zus,
AUC ntawm metabolite LAY151: nce los ntawm 1.6, 3.2 thiab 7.3 npaug, ntsig txog
AUC ntawm cov khoom siv metabolite BQS867: nce 1.4, 2.7 thiab 7.3 npaug, ntsig txog.

Cov ntaub ntawv tsis tshua muaj nyob hauv theem pib ntawm CKD (mob raum tsis zoo) qhia tias qhov ntsuas ntawm pawg no zoo ib yam li cov neeg mob uas muaj mob raum tsis zoo. Qhov kev sib zog ntawm LAY151 metabolite hauv lub davhlau ya nyob twg ntawm CKD nce li 2-3 zaug piv nrog qhov kev suav ntawm cov neeg mob uas muaj mob raum tsis zoo.

Nrog rau qhov mob hemodialysis, vildagliptin kev tshem tawm tsuas yog muaj tsawg (4 teev tom qab ib koob yog 3% nrog sijhawm ntev dua 3-4 teev).

Hauv cov neeg mob laus (tshaj 65-70 xyoo), qhov siab tshaj plaws ntawm kev noj qab haus huv ntawm vildagliptin los ntawm 32%, C_max - 18% tsis cuam tshuam rau DPP-4 kev cuam tshuam thiab tsis yog qhov tseem ceeb hauv tsev kho mob.

Cov tshuaj Pharmacokinetic tseem ceeb hauv cov neeg mob uas muaj hnub nyoog qis dua 18 xyoo tsis tau tsim.

Galvus, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Galvus ntsiav tshuaj noj ntawm qhov ncauj, tsis hais txog ntawm kev ua zaub mov.

Cov koob tshuaj yuav tsum raug xaiv coj mus rau hauv tus kheej qhov kev ua tau zoo thiab kev tiv taus ntawm cov tshuaj.

monotherapy lossis sib xyaw nrog thiazolidinedione, metformin lossis insulin: 50 mg 1-2 zaug ib hnub, tab sis tsis ntau tshaj 100 mg,
ob chav sib xyaw nrog kev kho mob sulfonylurea: 50 mg ib hnub ib zaug, thaum sawv ntxov. Hauv cov neeg mob ntawm cov qeb no, kev kho mob ntawm kev noj Galvus hauv ib koob tshuaj 100 mg txhua hnub zoo ib yam li cov tshuaj ntawm 50 mg rau ib hnub,
kho peb zaug ua ke nrog kev tswj hwm tib txhij ntawm sulfonylurea thiab metformin derivatives: 100 mg rau ib hnub.

Yog tias qhov koob tshuaj txhua hnub yog 50 mg, nws tau noj ib zaug, thaum sawv ntxov, yog 100 mg - 50 mg thaum sawv ntxov thiab yav tsaus ntuj. Yog tias koj hla qhov kev siv tshuaj ntxiv lawm, koj yuav tsum noj sai li sai tau thaum nruab hnub. Koj tsis tuaj yeem tso cai noj Galvus hauv ib koob tshuaj uas tshaj li tus neeg niaj hnub.

Thaum tsis muaj glycemic txaus tswj thaum lub sij hawm monotherapy ntawm qhov siab tshaj plaws txhua hnub 100 mg, kev kho yuav tsum tau ntxiv los ntawm kev teem sij hawm ntawm sulfonylurea, metformin, thiazolidinedione lossis insulin derivatives.

Nrog cov mob me me mus rau lub raum ua rau lub raum tsis zoo, creatinine tshem tawm (CC) siab dua 50 ml / min tsis hloov pauv ntawm Galvus.

Nrog mob pes tsawg (CC 30–50 ml / min) thiab mob hnyav (CC tsawg dua 30 ml / min) lub raum tsis ua haujlwm, suav nrog lub davhlau ya nyob twg ntawm cov mob raum (cov neeg mob los yog cov neeg mob hemodialysis), koob tshuaj Galvus noj ib zaug, thiab nws tsis yuav tsum ntau tshaj 50 mg.

Hauv cov neeg mob laus (tshaj 65 xyoo), kev kho ntawm kev muab tshuaj ntau npaum li ntawm Galvus tsis yog yuav tsum tau ua.

Sab sij huam

Kev tsim kho ntawm qhov tsis xav tau thaum lub sij hawm monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg sawv cev hauv feem ntau yog mob me, ib ntus thiab tsis xav tau kev tshem tawm ntawm Galvus.

Cov tsos mob ntawm cov mob angioedema feem ntau pom thaum ua ke nrog angiotensin-hloov enzyme inhibitors. Feem ntau nws yog mob hnyav, hla ntawm nws tus kheej tawm tsam ntawm keeb kwm ntawm kev kho mob tsis tu ncua.

Tsis tshua muaj txiaj ntsig, kev siv Galvus ua rau mob siab thiab lwm yam kev cuam tshuam ntawm daim siab ua haujlwm ntawm chav kawm asymptomatic. Feem ntau, cov xwm txheej no tsis tas yuav muaj kev kho mob, thiab tom qab kev tshem tawm ntawm Galvus, lub siab ua haujlwm tau rov qab.

Kev nce siab ntawm daim siab enzymes ntawm koob tshuaj vildagliptin 50 mg 1-2 zaug hauv ib hnub hauv feem ntau yog asymptomatic, tsis nce zuj zus thiab tsis ua rau cholestasis lossis jaundice.

Nrog rau cov tshuaj monotherapy nyob rau hauv ib koob ntawm 50 mg 1-2 zaug hauv ib hnub, cov kev tsis zoo hauv qab no yuav tsim:

los ntawm cov leeg hlwb: feem ntau - kiv taub hau, tsis xws luag - mob taub hau,
cab thiab kis kab mob: muaj tsawg - nasopharyngitis, mob hlab pas sab sauv,
los ntawm cov hlab ntsha: ncaw - peripheral edema,
los ntawm kev mob plab hnyuv: ua haujlwm dhau los - cem quav.

Nrog kev sib xyaw ntawm Galvus hauv ib koob li 50 mg 1-2 zaug hauv ib hnub nrog metformin, qhov pom ntawm kev phiv yog muaj peev xwm ua tau:

los ntawm cov leeg hlwb: feem ntau - mob taub hau, tshee hnyo, kiv taub hau,
los ntawm kev mob plab hnyuv: feem ntau - xeev siab.

Kev sib xyaw ua ke nrog metformin tsis cuam tshuam rau tus neeg mob lub cev qhov hnyav.

Thaum ua ntawv thov Galvus hauv ib koob tshuaj 50 mg txhua hnub nrog sulfonylurea derivatives, cov kab mob hauv qab no tuaj yeem pom hauv tus neeg mob:

cab thiab kis kab mob: muaj tsawg - nasopharyngitis,
los ntawm lub plab zom mov: tshwm sim - cem quav,
los ntawm cov leeg hlwb: feem ntau - mob taub hau, tshee hnyo, kiv taub hau, asthenia.

Qhov hnyav ntawm tus neeg mob tsis nce ntxiv thaum ua ke nrog glimepiride.

Kev siv Galvus hauv ib koob ntawm 50 mg 1-2 zaug ib hnub hauv kev sib xyaw nrog thiazolidinedione derivatives tuaj yeem ua rau cov kev xav tsis zoo hauv qab no:

los ntawm cov hlab ntsha: feem ntau - peripheral edema,
los ntawm sab ntawm cov metabolism thiab khoom noj khoom haus: feem ntau - kev nce hauv lub cev hnyav.

Noj Galvus hauv ib koob li 50 mg 2 zaug hauv ib hnub nrog cov tshuaj insulin tuaj yeem ua rau:

los ntawm cov leeg hlwb: feem ntau - mob taub hau, nrog ib tus tsis paub tseeb - asthenia,
los ntawm lub plab zom mov: feem ntau - lub plab hnyuv plab zom mov, xeev siab, ua tsis xws luag - nrawm, raws plab,
los ntawm ib sab ntawm cov metabolism thiab khoom noj khoom haus: feem ntau - hypoglycemia,
cov teeb meem dav dav: feem ntau - ua daus no.

Qhov hnyav ntawm tus neeg mob hauv qhov kev sib txuam no tsis nce ntxiv.

Kev siv ntawm Galvus 50 mg 2 zaug hauv ib hnub nyob rau hauv ua ke nrog metformin thiab sulfonylurea npaj tuaj yeem ua rau kev txhim kho cov kev mob tshwm sim hauv qab no:

los ntawm ib sab ntawm cov metabolism thiab khoom noj khoom haus: feem ntau - hypoglycemia,
los ntawm cov leeg hlwb: feem ntau - tshee, kiv taub hau, asthenia,
dermatological tshua: feem ntau - hyperhidrosis.

Kev kho ua ke nrog peb zaug tsis cuam tshuam rau tus neeg mob lub cev qhov hnyav.

Tsis tas li ntawd, cov kev tshwm sim tsis zoo hauv qab no tau muab sau rau hauv cov kev tshawb fawb tom qab sau npe: urticaria, nce kev ua si ntawm daim siab enzymes, kab mob siab, kab mob ntsws, mob tawv nqaij ntawm tawv nqaij lossis exfoliative etiology, myalgia, arthralgia.

Cov lus qhia tshwj xeeb

Tus neeg mob yuav tsum tau qhia txog qhov yuav tsum tau mus ntsib tus kws kho mob thaum muaj kev nyuaj siab txog cov kev mob tshwm sim los yog cov tsos mob ntawm lwm qhov kev tsis txaus ntseeg nyob hauv keeb kwm yav dhau los ntawm kev siv cov ntsiav tshuaj.

Cov tshuaj tsis ua rau lub cev tsis muaj zog.

Hauv cov neeg mob tshuaj insulin, Galvus tsuas yog siv los ua ke nrog cov tshuaj insulin.

Hauv kev mob plawv tsis ua hauj lwm hauv chav kawm Kuv ua haujlwm kev faib tawm NYHA tshuaj muaj peev xwm ua yam tsis muaj kev txwv nyob rau hauv cov kev tawm dag zog lub cev.

Hauv kev mob plawv tsis ua hauj lwm hauv chav kawm II, yuav tsum tau txwv qee yam ntawm lub cev, vim tias lub nra ib txwm ua rau tus neeg mob plawv, tsis muaj zog, ua pa luv, nkees. Thaum so, cov tsos mob no tsis tuaj.

Yog tias cov tsos mob ntawm tus mob pancreatitis tshwm sim, vildagliptin yuav tsum tsis ua mus ntxiv.

Ua ntej pib siv thiab tom qab ntawd ua ntu zus txhua 3 lub hlis nyob rau thawj xyoo ntawm kev kho, nws raug nquahu kom ua kev tshawb nrhiav biochemical ntawm lub siab ua haujlwm ntsuas, txij li kev coj ua ntawm Galvus hauv qee qhov xwm txheej tsawg tuaj yeem ua rau muaj kev cuam tshuam ntawm aminotransferases. Yog tias thaum lub sijhawm kawm thib ob, cov haujlwm kev ua ntawm alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST) tshaj li kev txwv sab sauv ntawm qhov kev ntsuas los ntawm 3 zaug lossis ntau dua, cov tshuaj yuav tsum tau txiav tawm.

Nrog rau kev txhim kho cov cim ntawm lub siab ua haujlwm tsis zoo (suav nrog jaundice) thaum noj Galvus, kev txiav tawm tam sim ntawd ntawm cov tshuaj yog qhov xav tau, nws tsis tuaj yeem rov qab noj tom qab kho dua ntawm lub siab ua haujlwm ntsuas.

Txo cov kev pheej hmoo ntawm hypoglycemia thaum sib xyaw nrog sulfonylurea kev npaj, nws raug nquahu kom siv lawv hauv qhov tsawg kawg.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tib lub sijhawm Galvus nrog glibenclamide, metformin, pioglitazone, amlodipine, ramipril, digoxin, valsartan, simvastatin, warfarin, tsis muaj kev sib txuam tseem ceeb hauv tsev kho mob.

Cov nyhuv ntshav hypoglycemic ntawm vildagliptin tej zaum yuav raug txo qis thaum ua ke nrog thiazides, glucocorticosteroids, sympathomimetics, thiab cov thyroid hormones npaj.

Qhov ntxim nyiam ntawm kev txhim kho angioedema nce nrog concomitant kho nrog angiotensin hloov enzyme inhibitors. Nws yuav tsum raug sau tseg tias vildagliptin yuav tsum txuas mus ntxiv nrog cov tsos mob ntawm tus mob angioedema, vim nws dhau mus zuj zus, ntawm nws tus kheej thiab tsis tas yuav tsum tsis ua rau kev kho mob.

Kev sib cuam tshuam ntawm Galvus nrog cov tshuaj uas yog cov quav, ua kom pom tseeb lossis inhibitors ntawm cytochrome P yuav tsis zoo li₄₅₀ (CYP).

Galvus tsis muaj kev cuam tshuam rau cov tshuaj metabolic npaum li cas uas yog cov roj ntsha hloov pauv ntawm cov enzymes CYP1A2, CYP3A4, CYP3A5, CYP2C8, CYP2C9, CYP2D6, CYP2C19, CYP2E1.

Cov qauv ntawm Galvus yog: Vildagliptin, Galvus Met.