Ciprofloxacin 250 thiab 500 mg ntsiav tshuaj

Kev piav qhia cuam tshuam rau 20.08.2015

• Lub npe Latin: Ciprofloxacinum
• ATX Code: S03AA07
• Yam tshuaj muaj sia: Ciprofloxacin (Ciprofloxacinum)
• Chaw tsim tshuaj paus: PJSC “Farmak”, PJSC “Tus Kws Tshaj Lij”, OJSC “Kyivmedpreparat” (Ukraine), LLC “Ozon”, OJSC “Veropharm”, OJSC “Kev Sib Tham” (Russia), C.O. Tuam txhab Rompharm S.R.L. (Romania)

Pob ntseg thiab qhov muag tee ciprofloxacin muaj ciprofloxacin hydrochloride ntawm kev saib xyuas ntawm 3 mg / ml (hauv qhov tseeb ntawm cov tshuaj ntshiab), Trilon B, benzalkonium chloride, sodium chloride, dej lim.

Hauv cov tshuaj pleev qhov muag, cov tshuaj yeeb dej cawv kuj tseem muaj nyob hauv ib qho concentration ntawm 3 mg / ml.

Cov tshuaj Ciprofloxacin: 250, 500 lossis 750 mg ntawm ciprofloxacin, MCC, qos yaj ywm hmoov txhuv, pob kws nplej siab, hypromellose, croscarmellose sodium, talc, magnesium stearate, colloidal anhydrous silicon dioxide, macrogol 6000, ntxiv tshuaj E171 (titanium dioxide), polysorbate 80.

Txoj kev lis ntshav daws muaj cov tshuaj nquag ntawm qhov chaw siab ntawm 2 mg / ml. Cov muaj mob: sodium chloride, edetate disodium, lactic acid, diluted hydrochloric aciddej d / thiab.

Cov Tshuaj Hauv Tshuaj

Lub tshuab kev ua haujlwm ntawm cov tshuaj yog vim muaj peev xwm los tiv thaiv DNA gyrase (ib qho enzyme ntawm cov kab mob hlwb) nrog kev tsis haum DNA ua ke, kev faib thiab kev loj hlob ntawm cov kab mob me me.

Wikipedia qhia tias, tiv thaiv keeb kwm yav dhau los ntawm kev siv yeeb tshuaj, kev tawm tsam lwm cov tshuaj tiv thaiv kev tsis haum tshuaj tsis txhim kho, tshuaj tua kab mobCov. Qhov no ua rau ciprofloxacin ua tau zoo tiv thaiv cov kab mob tiv thaiv kev ua haujlwm. tshuaj penicillins, chaw rauv taws, tetracycline, cephalosporins thiab ib tug lej ntawm lwm tus tshuaj tua kab mob.

Kev nquag tshaj tawm ntawm Gram (-) thiab Gram (+) aerobes: H. influenzae, N. gonorrhoeae, Salmonella spp., P. aeruginosa, N. meningitidis, E. coli, Shigella spp.

Ua tau zoo nyob rau hauv kev kis mob tshwm sim los ntawm: lim staphylococcus (suav nrog cov tsim cov tshuaj penicillinase), muaj cov leeg ntshav enterococcus, legionella, pw tom hav zoov, mob chlamydia, mycoplasma, mycobacteria.

Nquag ua haujlwm tiv thaiv beta-lactamase-ua microflora.

Anaerobes muaj ntsis sib xyaw lossis tshuaj tiv thaiv. Yog li ntawd, cov neeg mob nrog kev sib xyaw tus kab mob anaerobic thiab aerobic ciprofloxacin kev kho mob yuav tsum tau ntxiv cov tshuaj noj lincosamides lossis Metronidazole.

Ruaj tiv dhau tshuaj tua kab mob yog: Ureaplasma urealyticum, Streptococcus faecium, Treponema pallidum, Nocardia asteroides.

Cov tshuaj tiv thaiv ntawm cov kab mob me me rau cov tshuaj yog tsim maj mam.

Cov Tshuaj Pharmacokinetics

Tom qab noj cov tshuaj, cov tshuaj sai thiab nrawm rau hauv plab zom mov.

Lub ntsiab pharmacokinetic ntsuas:

• bioavailability - 70%,
• TCmax hauv cov ntshav ntshav - 1-2 teev tom qab kev tswj hwm,
• T½ - 4 teev

Ntawm 20 thiab 40% ntawm cov khoom txuas rau cov protein ntshav. Ciprofloxacin tau txais kev faib tawm zoo hauv cov kua nruab nrog cev thiab cov nqaij hauv lub cev, thiab nws cov concentration hauv cov ntaub so ntswg thiab cov kua dej ua tau ntau dua plasma ntshav.

Nws kis tau los ntawm cov placenta mus rau hauv cov kua dej hauv cerebrospinal, tawm hauv cov kua mis, thiab cov ntsiab lus siab tau tsau hauv cov kua tsib. Txog li 40% ntawm cov koob tshuaj uas tau muab tshem tawm hauv 24 teev tsis hloov pauv los ntawm ob lub raum, ib feem ntawm cov koob tshuaj tawm hauv cov kua tsib.

Dab tsi yog qhov tshuaj rau hauv daim ntawv ntawm qhov muag / pob ntseg pob?

Hauv ophthalmology yog siv rau superficial kab mob kis tau ntawm lub qhov muag (lub qhov muag) thiab nws cov appendages, nrog rau nrog mob txhab keratitis.

Cov lus qhia rau kev siv ciprofloxacin hauv otology: mob kab mob otitis sab nraud zoo heev thiab cov mob otitis ua mob ntawm nruab nrab pob ntseg hauv cov neeg mob nrog tympanostomy raj.

Cov Yuav Tsum Muaj

Cov Txheej Txheem Tshaj Tawm rau kev siv system:

• kev tiv thaiv tsis haum
• cev xeeb tub
• kev pub mis
• cov lus hais raum / mob siab ua hauj lwm,
• kev qhia txog keeb kwm ntawm kev mob kaum hauv tus kab mob los ntawm kev siv quinolones.

Ncos rau qhov muag thiab pob ntseg yog contraindicated hauv fungal thiab kis mob ntawm lub qhov muag / pob ntseg, nrog kev tsis nkag siab rau ciprofloxacin (lossis lwm yam quinolones), thaum cev xeeb tub thiab lactation.

Rau cov menyuam yaus, ntsiav tshuaj thiab ib qho kev daws teeb meem rau kev tswj hwm yuav tuaj yeem tsim los ntawm 12 xyoo, qhov muag thiab pob ntseg poob los ntawm 15 xyoo.

Sab sij huam

Cov tshuaj zoo rau. Feem ntau cov kev mob tshwm sim nrog rau / hauv cov lus qhia thiab kev noj haus:

• kiv taub hau
• nkees
• mob taub hau
• tshee hnyo
• arousal.

Hauv phau ntawv qhia Vidal, nws tau tshaj tawm tias nyob rau hauv qee qhov xwm txheej, cov neeg mob sau cia:

• hws
• gait tsis zoo
• teeb meem txawv txav ntawm rhiab heev,
• dej ntas,
• intracranial tawg,
• kev nyuaj siab,
• kev ntshai ntawm kev ntshai
• pom kev pom
• flatulence,
• mob plab
• kem plab,
• xeev siab / ntuav
• zawv plab,
• kab mob siab,
• hepatocyte necrosis,
• tachycardia,
• leeg ntshav siab(tsis tshua muaj)
• khaus tawv
• cov tsos ntawm pob nyob ntawm daim tawv nqaij.

Tsis tshua muaj kev phiv: bronchospasm, anaphylactic poob siab, Quincke's edema, arthralgia, petechiae, malignant exudative erythema, vasculitis, Lyell cov tsos mob, mob leukemia thiab thrombocytopenia, eosinophilia, anemia, hemolytic anemia, mob ntsws vwm los yog mob leukocytosis, nce ntshav ntau ntau ntawm LDH, bilirubin, alkaline phosphatase, daim siab hloov chaw, creatinine.

Daim ntawv thov hauv ophthalmology yog nrog los ntawm:

• feem ntau - zoo nkaus li tsis xis nyob thiab / lossis muaj lub cev txawv teb chaws nyob rau hauv lub qhov muag, cov tsos ntawm cov quav hniav dawb (feem ntau hauv cov neeg mob nrogmob txhab keratitis thiab nrog rau kev siv ntau zaus siv rau tee), kev tsim cov muaju / plaub ya ri, ua ke sib tshooj thiab hyperemia, tingling thiab hlawv,
• nyob rau hauv raug mob cais - keratitis/keratopathy, tawv muag daj, staining ntawm lub qhov muag, kev tsis nco qab lub cev, lacrimation, qhov muag pom tsis meej, photophobia, mob rau lub ntsej muag.

Cov kev mob tshwm sim los cuam tshuam nrog lossis cuam tshuam txog kev siv cov tshuaj feem ntau me me, ua rau tsis muaj kev hem thawj thiab ploj mus yam tsis tau kho.

Hauv cov neeg mob nrog mob txhab keratitis cov tsos ntawm cov xim dawb tsis cuam tshuam loj heev rau kev kho mob thiab cov ciaj ciam ntawm lub zeem muag thiab ploj ntawm nws tus kheej. Raws li txoj cai, nws tshwm nyob rau hauv lub sijhawm txij li 1-7 hnub tom qab pib lub sijhawm ntawm kev siv cov tshuaj thiab ploj mus sai lossis lossis 13 hnub tom qab nws txiav.

Neophthalmic ntshawv siab thaum siv cov tee: qhov pom ntawm tsis kaj siab tom qab lub qhov ncauj, nyob rau hauv cov neeg mob tsawg - xeev siab, dermatitis.

Thaum siv rau hauv otology, cov hauv qab no yog ua tau:

• feem ntau - sib zog hauv pob ntseg,
• hauv qee kis - tinnitus, mob taub hau, dermatitis.

Kev siv cov ampoules

Ciprofloxacin hauv ampoules raug pom zoo kom muab tshuaj rau hauv cov ntawv uas tsis muaj qhov txau ntshav. Qhov koob tshuaj rau ib tus neeg laus yog 200-800 mg / hnub. Lub sijhawm ua haujlwm ntawm thaj tsam yog li ntawm 1 lub lis piam txog 10 hnub.

Ntawm urogenital mob, sib koom tes puasthiabpob txha lossis Cov kabmob tus neeg mob tau txhaj 200-400 mg ob zaug ib hnub. Ntawm ua pa ntawm kab mob, kev kis tus mob ntawm leeg, septicemia, cov nqaij mos thiab cov tawv nqaij mob koob tshuaj ib zaug nrog tib zaus siv yog 400 mg.

Ntawm raum tsis ua hauj lwm qhov pib koob tshuaj yog 200 mg, tom qab nws tau kho kho rau hauv tus account Clcr.

Hauv kev siv tshuaj ampoules hauv ib koob tshuaj 200 mg, Txoj kev lis ntshav yog 30 feeb, nrog kev qhia ntawm cov tshuaj hauv ib koob ntawm 400 mg - 1 teev.

Kev txhaj tshuaj Ciprofloxacin tsis raug sau tseg.

Yeem

Tsis muaj qhov sib txawv ntawm txoj kev yuav siv tshuaj los ntawm cov tuam txhab sib txawv: cov lus qhia rau kev siv Ciprofloxacin-AKOS zoo ib yam li cov lus qhia nyob rau hauv Ciprofloxacin-FPO, Ciprofloxacin-Txhawb, Vero-Ciprofloxacinlossis Ciprofloxacin-teva.

Rau cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo, cov tshuaj tau pom zoo kom raug tsuas yog tias cov kab mob tseem tiv taus lwm cov tshuaj tua kab mob.

Noj ntau dhau

Tsis muaj cov tsos mob tshwj xeeb nrog kev noj ntau tshaj ciprofloxacin. Tus neeg mob tau qhia lub plab zom mov, noj tshuaj emetic, tsim cov tshuaj tiv thaiv tso kua qaub, thiab qhia kom muaj kua ntau. Txhua yam haujlwm yuav tsum tau ua thaum tswj lub luag haujlwm ntawm cov tseem ceeb thiab cov kabmob.

Peritoneal lim ntshav tawm thiab hemodialysis pab txhawb rau kev tshem tawm 10% ntawm cov koob tshuaj tau noj.

Cov tshuaj tsis muaj cov tshuaj tshwj xeeb.

Kev sib txuam

Siv hauv nrog nrog Theophylline pab txhawb kev nce ntshav ntau ntxiv thiab ib qho nce ntxiv ntawm T1 / 2 ntawm tom kawg.

Al / Mg-muaj cov tshuaj tua kab mob pab ua kom qeeb ntawm kev nqus ntawm ciprofloxacin thiab yog li txo nws cov tshuaj lom neeg hauv cov zis thiab ntshav. Nyob nruab nrab ntawm cov tshuaj ntawm cov tshuaj no yuav tsum tswj kev ncua sij hawm tsawg kawg 4 teev.

Ciprofloxacin txhim kho cov nyhuv coumarin anticoagulants.

Kev sib cuam tshuam ntawm ciprofloxacin rau kev siv rau hauv otology thiab ophthalmology nrog lwm cov tshuaj tsis tau kawm.

Cov lus qhia tshwj xeeb

Vim tias qhov tshwm sim ntawm cov kev mob tshwm sim los ntawm lub hauv nruab nrab lub paj hlwb hauv cov neeg mob uas muaj keeb kwm ntawm nws cov kab mob pathology, cov tshuaj yuav siv tsuas yog kho mob.

Ciprofloxacin yog tshuaj nrog kev ceev faj thaum txo qis tshaj plaws rau qhov kev npaj tos qhua, qaug dab peg, mob hlwb, mob hlwb cerebrosclerosis heev (nce zoo yuav muaj cov ntshav tsis txaus thiab mob stroke), ntawm mob siab rau lub siab / raum kev ua haujlwmthaum laus.

Nyob rau lub sijhawm kho, nws raug nquahu kom tsis txhob UV thiab hnub ci thiab lub cev ua haujlwm ntau ntxiv, tswj lub acidity ntawm cov zis thiab haus dej haus kev nyab xeeb.

Hauv cov neeg mob uas muaj tshuaj alkaline muaj zis, cov kab mob tau sau tseg crystalluriaCov. Txhawm rau kom zam nws txoj kev txhim kho, nws tsis tuaj yeem lees txais dhau qhov kev kho mob ntawm cov tshuaj. Ntxiv rau, tus neeg mob yuav tsum haus dej kom ntau thiab kev saib xyuas cov tshuaj tiv thaiv tso kua qaub.

Tendon mob thiab cov paib tenosynovitis yog lub teeb liab ua kom tsis txhob kho mob, vim tias qhov yuav ua rau mob ntshav / caj dab ntawm txoj leeg yuav tsis raug txwv.

Ciprofloxacin tuaj yeem thaiv kev nrawm ntawm cov tshuaj tiv thaiv psychomotor (tshwj xeeb yog tiv thaiv tom qab cawv), uas yuav tsum nco ntsoov los ntawm cov neeg mob ua haujlwm nrog cov khoom siv phom sij.

Nrog txoj kev loj hlob raws plab heevyuav tsum tau muab tshem tawmpseudomembranous mob plabvim Tus kab mob no yog contraindication rau kev siv tshuaj.

Yog tias tsim nyog, kev sib txig iv kev tswj hwm ntawm barbiturates yuav tsum saib xyuas qhov haujlwm ntawm CCC: tshwj xeeb, ECG, lub plawv dhia, ntshav siab.

Cov kua ophthalmic daim ntawv ntawm cov tshuaj tsis yog npaj rau kev txhaj tshuaj rau intraocular.