Cov tshuaj Amoxiclav: cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

Cov muaj pes tsawg leeg ntsiav tshuaj 250 mg / 125 mg lub Cheebtsam nrog amoxicillin (daim ntawv ntawm trihydrate) thiab clavulanic acid (potassium ntsev daim ntawv). Cov ntsiav tshuaj kuj tseem muaj tus pabcuam: MCC sodium croscarmellose.

Amoxiclav ntsiav tshuaj 2X 625 mg thiab 1000 mg muaj lub ntsiab lus amoxicillin thiab clavulanic acid, ntxiv rau cov khoom siv ntxiv: anhydrous colloidal silicon dioxide, flavors, aspartame, daj hlau oxide, talc, roj nplua nyeem roj, MCC silicate.

Tsim ntawm ntsiav tshuaj Amoxiclav Quicktab 500 mg thiab 875 mg muaj cov khoom xyaw nquag amoxicillin thiab clavulanic acid, ntxiv rau cov khoom siv ntxiv: anhydrous colloidal silicon dioxide, flavings, aspartame, daj hlau oxide, talc, hydrogen castor roj, MCC silicate.

Tsim ntawm cov hmoov los ntawm qhov kev ncua ntawv yog npaj Amoxiclavkuj tseem muaj amoxicillin thiab clavulanic acid, thiab kuj yog cov khoom siv tsis muaj zog suav nrog sodium citrate, MCC, sodium benzoate, mannitol, sodium saccharin.

Tsim ntawm hmoov rau qhov kev npaj infusion Amoxiclav iv muaj amoxicillin thiab clavulanic acid.

Daim ntawv tso tawm

Cov tshuaj yog nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Amoxiclav 250 mg / 125 mg - cov ntsiav tshuaj xim, pob muaj 15 pcs.

Amoxiclav 2X (500 mg / 125 mg, 875 mg / 125 mg) - ntsiav tshuaj, uas tau coated, tej zaum yuav muaj 10 lossis 14 pcs.

Amoxiclav Quicktab (500 mg / 125 mg, 875 mg / 125 mg) muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj tawg, hauv pob ntawv - 10 xws li cov ntsiav tshuaj.

Tsis tas li, cov khoom lag luam yog tsim los ntawm cov hmoov uas qhov kev rho tawm tau ua; lub raj mis muaj cov hmoov ntim rau kev npaj 100 ml ntawm cov khoom.

Hmoov kuj tsim tawm, los ntawm cov tshuaj uas tau tsim, uas tau tswj kav dej kom tiav. Lub raj mis muaj 600 mg ntawm cov tshuaj (amoxicillin 500 mg, clavulanic acid 100 mg), 1.2 g lub raj mis tseem muaj (amoxicillin 1000 mg, clavulanic acid 200 mg), 5 fl.

Pharmacological kev txiav txim

Cov Lus qhia muab cov ntaub ntawv uas tshuaj tua kab mob Amoxiclav (INN Amoksiklav) yog ib tus neeg sawv cev dav dav. Tshuaj tua kab mob pab pawg: qhov dav-spectrum penicillins. Cov tshuaj sib xyaw ua ke muaj cov tshuaj amoxicillin (penicillin ib nrab hluavtaws) thiab clavulanic acid (β-lactamase inhibitor). Muaj cov clavulanic acid nyob rau hauv kev npaj ua tiav kom muaj kev tawm tsam ntawm amoxicillin rau kev ua ntawm β-lactamases, uas yog tsim los ntawm cov kab mob me me.

Cov qauv ntawm clavulanic acid zoo ib yam li cov tshuaj tua kab mob beta-lactam, cov tshuaj yeeb tshuaj no tseem muaj cov nyhuv tua tshuaj. Amoxiclav tawm tsam tawm tsam cov kab mob uas nthuav tawm rhiab heev rau amoxicillin. Nov yog kab kab mob gram-zoo, aerobic gram-cov kab mob tsis zoo, gram-zoo thiab gram-negative anaerobes.

Pharmacokinetics thiab cov chaw muag tshuaj

Raws li phau ntawv qhia kev siv tshuaj Vidal, tom qab kev tswj hwm ntawm qhov ncauj, ob qho tshuaj lom tawm ntawm lub plab zom mov, kev nqus ntawm cov khoom tsis cuam tshuam los ntawm kev noj zaub mov, yog li nws tsis muaj teeb meem yuav noj nws li cas ua ntej lossis tom qab noj mov. Kev siab tshaj plaws hauv ntshav pom ib teev tom qab siv tshuaj. Ob lub tshuaj ua haujlwm nquag ntawm cov tshuaj tau muab faib rau hauv dej thiab cov ntaub so ntswg. Amoxicillin tseem nkag mus rau hauv lub siab, kua dej synovial, prostate, tonsils, gall zais zis, cov leeg nqaij, qaub ncaug, lub ntsej muag tawm.

Yog tias daim nyias nyias ntawm lub paj hlwb tsis kub, ob qho khoom ua ke tsis nqus los ntawm BBB. Nyob rau tib lub sijhawm, cov cuab yeej ua kom zoo siab hla tus txheej txheem placental, lawv cov khoom siv yog txiav txim siab hauv niam mis. Lawv khi rau cov ntshav cov ntshav kom tsawg.

Hauv lub cev, amoxicillin yauv nyob ib nrab metabolism hauv, clavulanic acid yog metabolized sib zog. Nws yog tawm hauv lub cev los ntawm lub raum, cov kab mob tsis txaus ntseeg ntawm cov tshuaj ua kom muaj zog yog tawm ntawm txoj hnyuv thiab lub ntsws. Ib nrab-lub neej ntawm amoxicillin thiab clavulanic acid yog 1-1.5 teev.

Kev taw qhia txog kev siv Amoxiclav

Amoxiclav raug samfwm rau kev kis kabmob thiab mob kis kabmob vim tias muaj kev cuam tshuam ntawm cov tsiaj mob me me rau cov tshuaj no. Qhov taw qhia hauv qab no rau kev siv cov tshuaj no tau txiav txim siab:

kis kab mob ntawm ENT plab hnyuv siab raum, nrog rau cov kab mob sib kis ntawm cov pa ntawm sab saud (otitis mediapharyngeal rwj, mob hlab ntsws, pharyngitistonsillitis)
mob txeeb zig (nrog cystitisntawm prostate lwm yam)
cov kab mob sib kis ntawm cov pa hauv txoj hlab ntsws qis (mob ntsws, mob ntswsmob thiab mob raum)
gynecological kab mob ntawm kev kis tus kab mob,
kis kab mob ntawm cov kab mob sib txuas thiab pob txha,
kis kab mob ntawm cov nqaij mos, tawv nqaij (nrog rau qhov tshwm sim ntawm kev tom),
biliary huam mob (cholangitis, cholecystitis),
odontogenic tau tus kab mob.

Dab tsi ntxiv pab Amoxiclav, koj yuav tsum nug tus kws kho mob tshwj xeeb rau kev sab laj tus kheej.

Cov Yuav Tsum Muaj

Kev txiav txim siab vim li cas tshuaj ntsuab thiab lwm cov kev pab cuam ntawm cov tshuaj, ib qho kuj yuav tsum coj mus rau hauv tus account contraindications uas twb muaj lawm:

mononucleosis mob sib kis,
kab mob siab yav dhau los lossis mob siab daj ntseg thaum noj clavulanic acid lossis amoxicillin,
lymphocytic leukemia,
siab rhiab heev rau cov tshuaj tua kab mob los ntawm pab pawg ntawm cephalosporins, penicillins, thiab lwm yam tshuaj tua kab mob beta-lactam,
siab rhiab heev rau cov nquag tshuaj ntawm cov tshuaj.

Nws ua tib zoo tshuaj rau cov neeg muaj kab mob siab, cov neeg muaj mob raum.

Sab sij huam

Thaum noj cov tshuaj tiv thaiv no, cov kev mob tshwm sim hauv qab no tuaj yeem tshwm sim hauv cov neeg mob:

Lub plab zom mov: tsis zoo qab losntuav xeev siab zawv plab, muaj qee zaus, kev mob tshwm sim ntawm kev mob plab, mob siab yog ua tau, ib qho kev qhia paub yog kab mob siab, mob daj ntseg, pseudomembranous mob plab.
Hematopoietic system: Muaj qee zaus, thim rov qab muaj leukopenia, thrombocytopenia, feem ntau tsis tshua mob - eosinophilia, pancytopenia.
Ua xua qhov tshwm sim: khauserythematous pob urticaria, muaj qee zaus - anaphylactic poob siabexudative erythema, o tuaj, kev tsis haum tshuaj vasculitis, ua rau pom ib leeg - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
Kev khiav dej num muaj zog: kiv taub hau, mob taub hau, tsis tshua muaj tshwm sim - pom tshwm sim, qhov kev xav ntawm qhov ntxhov siab, hyperactivity, insomnia.
Cov kab mob zis: crystalluria, interstitial nephritis.
Muaj qee zaus, kev nrhiav tau superinfection yuav tshwm sim.

Nws tau sau tseg tias xws li kev kho mob, raws li txoj cai, tsis ua rau tawm kev cuam tshuam txog kev phiv.

Cov lus qhia rau kev siv Amoxiclav (Txoj kev thiab noj tshuaj ntawm Amoxiclav rau cov neeg laus)

Cov tshuaj hauv cov tshuaj tsis yog rau cov menyuam yaus hnub nyoog qis dua 12 xyoos. Thaum muab tshuaj rau, nws yuav tsum tau yug los rau hauv lub siab tias qhov kev tso cai noj tshuaj ib hnub ntawm clavulanic acid yog 600 mg (rau cov neeg laus) thiab 10 mg rau 1 kg ntawm qhov hnyav (rau menyuam yaus). Kev tso cai noj tshuaj txhua hnub ntawm amoxicillin yog 6 g rau cov neeg laus thiab 45 mg rau 1 kg ntawm qhov hnyav rau ib tus menyuam.

Kev ua niam txiv npaj tau yog npaj los ntawm kev zom cov ntsiab lus ntawm lub thauv hauv dej rau kev txhaj tshuaj. Txhawm rau kom yaj 600 mg ntawm cov tshuaj, koj xav tau 10 moles ntawm dej, kom yaj 1.2 g ntawm cov tshuaj - 20 ml dej. Kev daws yuav tsum tau maj mam muab rau li 3-4 feeb. Txoj kev lis ntshav ntawm lub plab yuav tsum txuas ntxiv rau 30-40 feeb. Tsis txhob muab cia rau cov tshuaj.

Ua ntej tshuaj loog rau kev tiv thaiv cov teeb meem purulent, koj yuav tsum nkag mus rau hauv txoj leeg 1.2 g ntawm tshuaj. Yog tias muaj kev pheej hmoo ntawm cov teeb meem tshwm sim, cov tshuaj no tau muab tso quav lossis tau txais qhov ncauj ntawm lub sijhawm tom qab kev phais mob. Lub sijhawm sijhawm ntawm kev pub nkag yog txiav txim los ntawm tus kws khomob.

Amoxiclav ntsiav tshuaj, cov lus qhia rau kev siv

Raws li txoj cai, cov neeg laus thiab menyuam yaus (uas hnyav tshaj 40 kg) tau txais 1 ntsiav tshuaj txhua yim teev. (375 mg), muab hais tias tus kab mob yog mob sib khuav lossis mob pesnrab. Lwm txoj kev kho mob uas tsim nyog nyob rau hauv cov ntaub ntawv no yog 1 ntsiav tshuaj txhua 12 teev. (500 mg + 125 mg). Txog rau cov mob hnyav, nrog rau kev kis mob ntawm lub ntsws ua pa, 1 ntsiav tshuaj tau qhia txhua yim teev. (500 mg + 125 mg) lossis noj txhua 12 teev 1 ntsiav tshuaj. (875 mg + 125 mg). Nyob ntawm tus kab mob, koj yuav tsum tau noj tshuaj tiv thaiv kab mob rau tsib mus rau kaum plaub hnub, tab sis tus kws kho mob yuav tsum tau sau ib qho zuj zus los siv tshuaj kho mob.

Rau cov neeg mob uas muaj tus mob odontogenic, qhia cov tshuaj txhua 8 teev, 1 ntsiav tshuaj. (250 mg + 125 mg) lossis ib zaug 12 teev, 1 ntsiav tshuaj txhua. (500 mg + 125 mg) rau tsib hnub.

Cov neeg muaj ntsis lub raum tsis ua hauj lwm, pom qhov txais tos ntawm 1 rooj. (500 mg + 125 mg) txhua kaum ob teev. Kev mob raum tsis zoo yog qhov ua rau muaj qhov ncua sij hawm ntau ntxiv txog li 24 xuab moos.

Kev Raug Ncaj Qiv Amoxiclav, lus qhia rau kev siv

Cov menyuam yaus lub hnub nyoog ntawm tus neeg mob muab rau qhov muab xam los ntawm qhov ntsuas qhov hnyav ntawm tus menyuam. Ua ntej npaj cov kua dej, koj yuav tsum co lub raj mis kom zoo. Hauv ob lub koob tshuaj, 86 ml dej yuav tsum tau ntxiv rau hauv lub raj mis, txhua zaus koj yuav tsum tau co nws cov ntsiab lus zoo. Nws yuav tsum raug sau tseg tias ib rab diav ntsuas muaj 5 ml ntawm qhov khoom. Muab rau ib koob tshuaj nyob ntawm seb nws muaj hnub nyoog thiab hnyav.

Cov lus qhia rau siv Amoxiclav rau menyuam yaus

Txij thaum yug mus txog peb lub hlis, cov menyuam raug xaj tshuaj nyob rau ntawm 30 mg rau 1 kg ntawm qhov hnyav (koob tshuaj ib hnub), cov koob tshuaj no yuav tsum tau muab faib sib npaug thiab muab sijhawm nrog ib zaug. Txij li hnub nyoog muaj peb hlis, Amoxiclav raug tshuaj ntawm 25 mg rau 1 kg ntawm qhov hnyav, nws zoo ib yam li muab faib sib npaug rau ob koob. Yog tias muaj cov kab mob sib kis ntawm cov mob hnyav, qhov koob tshuaj tau hais tawm ntawm qhov nqi ntawm 20 mg rau 1 kg ntawm qhov hnyav, nws tau muab faib ua peb txoj kev tswj hwm. Hauv cov kab mob sib kis hnyav, koob tshuaj yog tawm ntawm tus nqi ntawm 45 mg rau 1 kg ntawm qhov hnyav, faib nws faib ua ob zaug ib hnub.

Cov lus qhia rau siv Amoxiclav Quicktab

Ua ntej noj, cov ntsiav tshuaj yuav tsum tau yaj hauv 100 ml dej (qhov dej yuav ntau dua). Do cov txheej kom zoo ua ntej siv. Koj tseem tuaj yeem zom cov ntsiav tshuaj, nws yog qhov zoo dua los siv cov tshuaj ua ntej noj. Cov neeg laus thiab menyuam yaus tom qab muaj hnub nyoog 12 xyoos yuav tsum noj 1 ntsiav tshuaj ib hnub. 625 mg 2-3 zaug ib hnub. Hauv cov mob hnyav, 1 lub tshuaj kho mob raug xaj tau. 1000 mg 2 zaug ib hnub. Txoj kev kho yuav tsum tsis pub ntev tshaj 2 lub lis piam.

Qee zaum tus kws kho mob tuaj yeem sau tshuaj analogues ntawm cov tshuaj, piv txwv li, Flemoklav Solutab thiab lwm tus.

Amoxiclav nrog angina

Tshuaj Amoxiclav mob caj pas ib tus neeg laus tshuaj 1 ntsiav tshuaj. 325 mg ib zaug txhua 8 teev. Lwm txoj kev kho mob ntxiv yuav tsum noj 1 lub tshuaj ib zaug txhua 12 teev. Tus kws kho mob yuav sau ntawv muab tshuaj rau cov tshuaj kom ntau dua yog tias tus kab mob ntawm cov neeg laus hnyav. Kev kho mob ntawm angina hauv menyuam yaus cuam tshuam nrog kev siv ncua ntawv. Raws li txoj cai, 1 diav yog tshuaj noj (ib lub tshuaj tsuas yog 5 ml). Qhov ntau zaus ntawm kev pub nkag yog txiav txim los ntawm tus kws kho mob, cov lus pom zoo uas yog qhov tseem ceeb ua raws. Kev noj cov tshuaj Amoxiclav rau cov menyuam yaus nrog angina nyob ntawm qhov mob hnyav heev.

Amoxiclav muab rau cov mob caj pas

Puas Amoxiclav pab nrog mob hlab ntsws, nyob ntawm qhov ua thiab cov yam ntxwv ntawm chav kawm ntawm tus kab mob. Qhov ntau npaum li tau txiav txim siab los ntawm tus kws kho mob otolaryngologist. Nws raug pom zoo kom koj noj 500 mg tshuaj peb zaug ib hnub. Pes tsawg hnub rau kev noj tshuaj yog nyob ntawm qhov mob hnyav ntawm tus kab mob. Tab sis tom qab cov tsos mob ploj, koj yuav tsum tau noj cov tshuaj rau ob hnub ntxiv.

Noj ntau dhau

Txhawm rau kom tsis txhob noj ntau tshaj, cov tshuaj muab rau cov menyuam yaus thiab noj tshuaj Amoxiclav rau cov neeg laus yuav tsum ua kom pom tseeb. Nws raug nquahu kom koj ua tib zoo kawm cov lus qhia lossis saib vis dis aus txog kev daws cov kev ncua.

Wikipedia qhia tias nrog kev noj tshuaj ntau dhau, ntau tus tsos mob tsis zoo yuav tshwm sim, tab sis tsis muaj ntaub ntawv qhia txog lub neej muaj mob rau tus neeg mob. Overdose yuav tshwm sim. mob plab, ntuav, zawv plabkev zoo siab. Nyob rau hauv cov mob hnyav, kev pom zoo tuaj yeem tshwm sim.

Yog tias cov tshuaj noj ntawd tsis ntev los no, pais plab lav tso tawm, ua rau pom tshuab txais carbonCov. Tus neeg mob yuav tsum tau soj ntsuam los ntawm kws kho mob. Siv tau qhov ntawd hemodialysis.

Kev sib txuam

Nrog rau kev sib txig sib xyaw ntawm cov tshuaj nrog qee cov tshuaj, qhov tsis xav tau tshwm sim, uas yog vim li cas cov ntsiav tshuaj, phoov thiab cov leeg tswj hwm ntawm cov tshuaj yuav tsum tsis txhob siv nyob rau hauv parallel nrog ib tug xov tooj ntawm cov tshuaj.

Ib txhij siv cov tshuaj nrog Glucosamine, tshuaj tiv thaiv kab mob, aminoglycosides, tshuaj laxative kom tsawg dua qhov kev nqus ntawm Amoxiclav, thaum noj ib txhij nrog Ascorbic acid - kev nqus yog nrawm.

Nrog rau kev kho mob ib txhij nrog phenylbutazone, diuretics, NSAIDs, Allopurinol thiab lwm yam tshuaj uas thaiv cov leeg, ua rau muaj qhov nce ntawm cov tshuaj amoxicillin tshwm sim.

Yog tias kev tswj hwm ib txhij ntawm cov tshuaj tiv thaiv anticoagulants thiab Amoxiclav ua tau, lub sijhawm prothrombin nce ntxiv. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau sau nyiaj hauv cov lus sib txuam zoo li no.

Amoxiclav tsub kom lub cev tsis lom ntxiv Methotrexate thaum noj nws.

Thaum noj Amoxiclav thiab Allopurinol qhov yuav ua rau muaj qhov tseeb ntawm exanthema nce.

Yuav tsum tsis txhob coj tib lub sijhawm Disulfiramthiab Amoxiclav.

Tus kws tswj hwm kev sib ntaus yog amoxicillin thiab RifampicinCov. Cov tshuaj ua rau lub cev ua rau lub zog ua haujlwm tsis zoo.

Cov tshuaj tiv thaiv Amoxiclav thiab bacteriostatic (tetracyclines, macrolides), thiab sulfonamides yuav tsum tsis txhob noj tib lub sijhawm, vim tias cov tshuaj no tuaj yeem txo Amoxiclav cov hauj lwm zoo.

Probenecid tsub kom lub siab ntawm amoxicillin thiab ua rau qeeb nws cov kev tshem tawm.

Thaum siv Amoxiclav, qhov kev ua tau zoo ntawm kev cuam tshuam ntawm kev tiv thaiv qhov ncauj yuav txo qis.

Cov lus qhia tshwj xeeb

Txij li feem ntau cov tib neeg muaj lymphocytic mob leukemia thiab nrog rau tus mob mononucleosis thiab tus uas tau txais Ampicillin, tom qab ntawd tau sau tseg qhov tshwm sim ntawm pob txuv erythematous, cov neeg zoo li no tsis pom zoo siv tshuaj tua kab mob ntawm cov ampicillin pawg.

Kev ceeb toom muab rau cov neeg uas muaj lub siab nyiam rau ua xua.

Yog hais tias ib chav kawm ntawm kev kho mob nrog cov tshuaj tau tawm rau cov neeg laus lossis menyuam yaus, nws yog qhov tseem ceeb los soj ntsuam raum, mob siab, thiab tsim ntshav.

Cov neeg uas lub raum tsis zoo lub cev yuav tsum tau txhaj tshuaj ntau dua lossis nce ntxiv nruab nrab ntawm cov tshuaj.

Nws yog qhov zoo dua rau noj cov tshuaj thaum noj mov txhawm rau txhawm rau txo qhov muaj feem ntawm kev phiv los ntawm lub plab zom mov.

Hauv cov neeg mob uas tau txais kev kho mob nrog Amoxiclav, qhov tshuaj tiv thaiv tsis zoo yuav raug pom hauv cov txheej txheem los txiav txim siab txog cov piam thaj hauv cov zis thaum siv Felling cov tshuaj lossis Benedict's reagent.

Tsis muaj cov ntaub ntawv hais txog qhov tsis zoo ntawm Amoxiclav txog kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem npliag.

Cov neeg mob uas mob siab rau Amoxiclav yog ib qho tshuaj tiv thaiv kab mob los yog tsis yog, nws yuav tsum tau yug los rau hauv lub siab tias cov tshuaj yog cov tshuaj tua kabmob.

Nws raug nquahu kom haus dej ntau thiab lwm yam dej haus thaum lub sijhawm kawm nrog tshuaj.

Yog tias Amoxiclav raug tshuaj, tus menyuam lub hnub nyoog ntawm tus neeg mob yuav tsum raug coj los txiav txim thaum sau daim ntawv ntawm cov tshuaj thiab ntau npaum li cas.

Amoxiclav analogs

Muaj ib tug xov tooj ntawm cov analogues ntawm cov tshuaj no. Tus nqi ntawm analogues nyob ntawm, ua ntej ntawm tag nrho cov, ntawm cov chaw tsim tshuaj paus ntawm cov tshuaj. Muaj cov analogues ntawm kev muag khoom pheej yig dua Amoxiclav. Rau cov neeg mob xav paub txog dab tsi tuaj yeem hloov cov tshuaj tua kab mob no, cov kws kho mob tshwj xeeb muaj cov npe loj ntawm cov tshuaj. Qhov no txhais tau Moxiclav, Co-Amoxiclav, Augmentin, Clavocin, Flemoklav, Medoclave, Baktoklav, Ranklav, AmovikombTxawm li cas los xij, tsuas yog ib tus kws kho mob thiaj li yuav tsum sau daim ntawv hloov chaw tuaj hloov xwb. Koj tuaj yeem xaiv qhov pheej yig dua nyob hauv cov ntsiav tshuaj, piv txwv li Augmentin. Koj tseem tuaj yeem xaiv ib tus Lavxias analogue, piv txwv li, Amoxicillin.

Qhov twg yog qhov zoo dua: Amoxiclav lossis Augmentin?

Dab tsi yog cov muaj pes tsawg leeg ntawm Amoxiclav thiab Augmentin, cov tshuaj no txawv li cas? Ob qho ntawm cov cuab yeej no muaj cov khoom sib thooj sib xws, uas yog, qhov tseeb, qhov no yog qhov qub. Raws li, cov nyhuv pharmacological ntawm cov tshuaj yuav luag zoo ib yam, nrog rau kev phiv. Tsuas yog cov neeg tsim khoom ntawm cov tshuaj no txawv.

Amoxiclav thaum cev xeeb tub thiab lactation

Amoxiclav ntawm cev xeeb tub tuaj yeem siv tau yog tias cov nyhuv xav tau tshaj qhov tsim kev puas tsuaj rau tus menyuam hauv plab. Kev siv tshuaj Amoxiclav nyob rau thaum ntxov ntawm kev xeeb tub yog qhov tsis xav tau. 2 lub hlis thiab 3 peb hlis muaj ntau dua, tab sis txawm tias lub sijhawm no, kev noj tshuaj ntawm Amoxiclav thaum cev xeeb tub yuav tsum pom tseeb meej heev. Amoxiclav pub niam mis tsis txhob sau ntawv tshuaj, txij li cov tshuaj ua kom nquag plias nkag mus rau niam mis.

Amoxiclav tshuaj xyuas

Hauv kev sib tham txog cov tshuaj Amoxiclav, kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob feem ntau yog qhov zoo. Nws raug sau tseg tias cov tshuaj tua kab mob ua tau zoo rau kev kho mob ua pa rau kev ua pa, thiab nws haum rau ob leeg rau cov laus thiab menyuam yaus. Cov kev tshuaj xyuas tau hais txog qhov ua tau zoo ntawm cov tshuaj rau cov hlab ntsws, rau kev tshaj tawm otitis, rau kev kis mob ntawm qhov chaw mos. Raws li txoj cai, cov neeg mob laus noj cov ntsiav tshuaj ntawm 875 mg + 125 mg, nrog rau txoj kev noj tshuaj kom haum, txoj kev daws mob sai sai. Hauv kev xyuas, nws tau sau tseg tias tom qab ib lub sijhawm ntawm kev siv tshuaj tua kab mob, nws raug nquahu kom noj cov tshuaj uas rov ua haujlwm li qub microflora.

Kev tshuaj xyuas ntawm Amoxiclav raug muab ncua cia kuj yog qhov zoo. Cov niam txiv sau tias nws yooj yim los muab cov khoom rau cov me nyuam, txij li nws muaj qab ntxiag thiab zoo li pom tau los ntawm menyuam yaus.

Tus nqi Amoxiclav, yuav qhov twg

Nqi Amoxiclav ntsiav tshuaj 250 mg + 125 mg qhov hnyav 230 rubles rau 15 pcs. Yuav cov tshuaj tiv thaiv 500 mg + 125 mg tuaj yeem them nqi ntawm 360 - 400 rubles rau 15 pcs. Npaum li cas yog cov ntsiav tshuaj 875 mg + 125 mgnyob ntawm qhov chaw muag khoom. Qhov nruab nrab, lawv cov nqi yog 420 - 470 rubles rau 14 pcs.

Nqi Amoxiclav Quicktab 625 mg - los ntawm 420 rubles rau 14 pcs.

Raug tshem tawm tus nqi Amoxiclav rau menyuam yaus - 290 rubles (100 ml).

Nqi Amoxiclav 1000 mg nyob rau hauv Ukraine (Kiev, Kharkov, thiab lwm yam) - los ntawm 200 hryvnias rau 14 daim.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj Amoxiclav yog tshuaj rau cov neeg mob hnub nyoog 12 xyoos thiab hnyav dua 40 kg.

Rau cov kab mob ntawm cov mob sib khuav mus rau mob hnyav cov tshuaj yog tshuaj hauv npaum li cas:

250 mg + 125 mg (375 mg) 3 zaug ib hnub,
500 mg + 125 mg (625 mg) 2 zaug ib hnub.

Hauv kev kis mob hnyav, ib yam nkaus li rau cov kab mob ua pa, Amoxiclav hauv cov ntsiav tshuaj sau rau hauv cov npaum li cas:

500 mg + 125 mg (625 mg) 3 zaug hauv ib hnub,
875 mg + 125 mg (1000 mg) 2 zaug ib hnub.

Kev noj tshuaj ntau tshaj txhua hnub ntawm amoxicillin rau cov neeg laus yog 6 g, clavulanic acid 600 mg.

Kev siv tshuaj ntau tshaj txhua hnub ntawm amoxicillin rau me nyuam yog 45 mg rau ib kg ntawm qhov hnyav, clavulanic acid 10 mg rau ib kg.

Lub sijhawm kho mob tuaj yeem yog 5 mus rau 14 hnub. Ntev npaum li cas rau kev siv tshuaj yuav tsum txiav txim los ntawm tus kws kho mob.

Hais txog kev kis mob ntawm lub qhov ncauj kab mob, Amoxiclav hauv kev noj 375 mg yog 3 zaug hauv ib hnub, ib koob tshuaj 625 mg - 2 zaug hauv ib hnub rau 5 hnub.

Yog tias tus neeg mob muaj lub raum mob nrog lub ntsej muag glomerular li ntawm 10 mus rau 30 ml ib feeb, tom qab ntawd cov tshuaj kho tau muab rau hauv qhov ntau npaum li 625 mg nrog ib nrab sijhawm ntawm 12 teev, yog tias creatine tshem tawm tsawg dua 10 ml ib feeb, ces qhov ntau zaus ntawm kev tswj hwm yog txo rau 1 zaug hauv ib hnub.

Thaum tsis muaj zis, lub sijhawm nruab nrab ntawm kev noj tshuaj ntxiv yuav tsum yog tsawg kawg 2 hnub.

Sab sij huam

Thaum noj tshuaj, cov kev xav tsis zoo hauv qab no tuaj yeem tshwm sim, uas tau hais tawm me ntsis thiab dhau mus tom qab kawg ntawm kev kho:

tsis qab los noj mov, raws plab, xeev siab, ntuav, ua tsis tau haujlwm rau lub siab,
ua xua
nce eosinophils, lub sijhawm ntev prothrombin sijhawm, txo qis cov qe ntshav,
ntau dhau kev ua si, ntxhov siab vim, pw tsaug zog, cramps, kiv taub hau, mob taub hau,
saline diathesis, interstitial nephritis,
superinfection, suav nrog thrush.

Raws li cov tshuaj nquag, amoxicillin thiab clavulanic acid yog ib feem ntawm cov ntsiav tshuaj:

Ntsiav tshuaj muab	Amoxicillin ntau npaum li cas	Tus nqi ntawm clavulanic acid
375 mg	250 mg	125mg
625 mg	500 mg	125 mg
1000 mg	875 mg	125 mg

Raws li cov khoom siv ntxiv, cov tshuaj muaj pes tsawg leeg suav nrog:

fumed silica,
MCC
talcum hmoov
magnesium stearate,
polyvinylpyrrolidone,
croscarmellose sodium.

Muaj pes tsawg leeg ntawm cov zaj duab xis membrane suav cov hauv qab no:

talcum hmoov:
ntxaib 80,
hypromellose,
qhov no yog lub hom phiaj
titanium oxide
triethyl citrate.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Amoxiclav yog tus cwj pwm pom los ntawm qhov kev pom tseeb hauv kev ua haujlwm ntawm antimicrobial. Cov kab mob me me hauv qab no yog cov tshuaj tua kab mob:

streptococci,
Yersinia enterocolitis,
staphylococci,
gardnerella qhov chaw mos,
E. coli
Klebsiella
gonococci
ua mob meningococci,
Ntxaug Yaj
salmonella
Tus kab mob vwm rau lub ntuj,
Kev ua Proteus
bacteroids
pertussis wand
pasteurella tua neeg,
fusobacteria,
brucella
campylobacter yuni,
Ducrey's wand,
khaub thuas wand
Helicobacter pylori,
moraxella cataralis,
peptococci,
peptostreptococcus,
clostridia
preotella.

Tom qab lub qhov ncauj tswj hwm, ob qho tshuaj yeeb dej cawv tau sai tawm ntawm txoj hnyuv, qhov siab tshaj plaws tau pom nyob tom qab ib teev. Noj mov tsis cuam tshuam rau kev nqus ntawm cov tshuaj.

Cov tshuaj tua kab mob nkag mus rau ntau cov ntaub so ntswg thiab cov plab hnyuv siab raum, hla mus rau qhov tso cov kuab tshuaj thiab cov ntshav tau tawm los ntawm cov kua mis.

Nws yog metabolized hauv daim siab, feem ntau tsuas yog nrog lub raum, ib nrab-lub neej nws txawv ntawm 1 mus rau 1.5 teev.

Hauv txoj kev mob raum loj dua, ib nrab-lub neej rau amoxicillin ntau ntxiv rau 7.5 teev, rau clavulanic acid rau 4,5 teev.

Cov lus thiab cov xwm txheej ntawm kev cia

Cov tshuaj yuav tau nrog kws kho mob noj. Cov tshuaj yuav tsum tau muab tso rau hauv qhov chaw qhuav uas me nyuam yaus tsis tuaj yeem nqa lawv, thaum t siab tshaj 25 максимумС.

(Cia koj rov los saib dua hauv cov lus)

* - Qhov txiaj ntsig nruab nrab ntawm ntau tus neeg muag khoom thaum lub sijhawm tshuaj xyuas tsis yog pej xeem kev pom

Amoxiclav ntsiav tshuaj thiab hmoov - cov lus qhia rau siv

Rau cov menyuam hnub nyoog qis dua 12 xyoos - 40 mg rau ib phaus ntawm qhov hnyav ib hnub.
Rau cov menyuam yaus uas lub cev hnyav dua 40 kg, cov tshuaj tau sau tseg ua tus laus.

Cov neeg laus tau tshuaj: 375 mg ntsiav tshuaj tau noj txhua 8 teev nyob rau ib hnub, 625 mg ntsiav tshuaj txhua 12 teev. Thaum kws kho mob muab tshuaj rau kho cov mob hnyav, cov koob tshuaj 625 mg txhua 8 teev, lossis 1000 mg txhua 12 teev, raug siv.

Nws yuav tsum raug sau tseg tias cov ntsiav tshuaj kuj yuav txawv ntawm qhov tsis muaj qhov sib piv ntawm cov tshuaj nquag. Yog li, koj tsis tuaj yeem hloov lub ntsiav tshuaj 625 mg (500 g ntawm amoxicillin thiab 125 g ntawm clavulanic acid) nrog ob 375 mg ntsiav tshuaj (250 g ntawm amoxicillin thiab 125 g ntawm clavulanic acid).

Cov qauv hauv qab no yog siv los kho tus kab mob odontogenic. 375 mg ntsiav tshuaj tau noj txhua 8 teev, puag ncig lub moos. 625 mg ntsiav tshuaj tom qab 12 teev.

Yog tias nws yuav tsum tau siv cov tshuaj los kho cov neeg mob raum, cov ntsiab lus tso zis creatinine yuav tsum raug coj los siv. Cov neeg mob mob siab yuav tsum tau soj ntsuam tas li ntawm lawv txoj haujlwm.

Hmoov rau kev ncua rau cov menyuam mos thiab menyuam yaus txog li 3 hlisCov. Kev muab tshuaj yog nqa tawm siv cov raj ntsuas tshwj xeeb lossis rab diav. Tsuas tshuaj - 30 mg ntawm amoxicillin rau ib phaus ntawm qhov hnyav, ob zaug ib hnub.

Rau cov menyuam yaus hnub nyoog ntau dua peb lub hlis rau kev kis mob me thiab mob nyhav - 20 mg / kg ntawm lub cev qhov hnyav, thiab rau kis hnyav - 40 mg / kg. Qhov tshuaj thib ob kuj tseem siv rau hauv kev kho mob ntawm kev sib sib zog nqus - mob ntawm pob ntseg hauv nruab nrab, mob siab, ntsws, mob ntsws. Ib qho kev qhia tau txuas rau cov tshuaj no, nyob rau hauv uas muaj cov ntxhuav tshwj xeeb uas tso cai rau koj kom laij cov tshuaj xav tau ntawm cov tshuaj rau cov menyuam yaus.

Qhov siab tshaj plaws tau tso cai noj tshuaj txhua hnub ntawm amoxicillin rau cov menyuam yaus yog 45 mg / kg ntawm qhov hnyav, rau cov laus - 6 grams. Clavulanic acid tuaj yeem noj nyob rau ib hnub tsis pub ntau tshaj 600 mg rau cov neeg laus thiab 10 mg / kg rau menyuam yaus.

Cov lus piav qhia tawm ntawm cov foos tso tawm

Cov tshuaj no muaj hauv cov qauv hauv cov ntsiav tshuaj uas muaj xim dawb los yog beige-dawb. Cov ntsiav tshuaj muaj oval biconvex duab.

Ib qho 625 mg ntsiav tshuaj muaj 500 mg ntawm amoxicillin trihydrate nrog 125 mg ntawm clavulanic acid (poov tshuaj ntsev).

Cov ntsiav tshuaj tuaj yeem tsim rau hauv cov kaus poom yas (15 ntsiav tshuaj txhua) lossis hauv cov kua xaim txhuas ntawm 5 lossis 7 daim.

1000 mg ntsiav tshuaj kuj raug coated, muaj ib daim duab oblong nrog beveled sawv. Ntawm lawv, ntawm ib sab tes, ib qho kev luam ntawm "AMS" yog thov, ntawm qhov tod - "875/125". Lawv suav nrog 875 mg ntawm cov tshuaj tua kab mob thiab 125 mg ntawm clavulanic acid.

Sib xyaw nrog lwm yam tshuaj

Nws yog qhov tsis tsim nyog siv ib txhij Amoxiclav thiab kev npaj ntawm anticoagulants tsis ncaj. Qhov no tuaj yeem ua rau nce sijhawm hauv prothrombin lub sijhawm.
Kev sib cuam tshuam ntawm Amoxiclav thiab allopurinol ua rau muaj kev pheej hmoo ntawm exanthema.
Amoxiclav txhim kho kev puas tsuaj ntawm metatrexate.
Koj siv tsis tau ob qho tib si amoxicillin thiab rifampicin - cov no yog cov antagonists, ua ke siv cov tshuaj tua kab mob ua kom tsis muaj zog ntawm ob qho tib si.
Amoxiclav yuav tsum tsis txhob raug coj ua ke nrog tetracyclines lossis macrolides (cov no yog cov tshuaj tua kab mob bacteriostatic), nrog rau sulfonamides vim tias txo qis hauv cov nyhuv ntawm cov tshuaj no.
Kev noj cov Amoxiclav txo cov kev ua kom muaj txiaj ntsig zoo hauv cov ntsiav tshuaj.

Cov kws kho mob tshuaj xyuas

Anna Leonidovna, kws kho mob, Vitebsk. Amoxiclav muaj txiaj ntsig ntau dua hauv kev kho mob ntawm ntau yam kab mob ua pa tsis xws li nws cov tshuaj tiv thaiv kab mob, amoxicillin. Kuv sau ntawv rau kev kawm txog 5 hnub, tom qab ntawd nws yog qhov tsim nyog yuav tsum tau coj cov tshuaj uas rov qab los kho microflora.

Veronika Pavlovna, urologist. Yawg Kryvyi Rih. Cov tshuaj no muaj cov nyhuv zoo heev rau cov kab mob hauv lub cev ntawm qhov chaw mos. Nws tsis tshua muaj kev phiv tshuaj, tib lub sijhawm kuv muab tshuaj tua kab mob, tom qab noj probiotics los kho microflora ib txwm.

Andrei Evgenievich, tus kws kho mob ENT, Polotsk. Kev siv cov tshuaj no los ntawm kev txhaj tshuaj tso cai rau koj kom sai sai qhov cuam tshuam ntawm kev mob hnyav thiab mob hnyav ntawm ENT kabmob. Cov tshuaj kho cov mob nyob hauv nruab nrab pob ntseg zoo. Ib qho ntxiv, cov neeg mob noj lub txiv qab zib tawm zoo.

Qhia txog ntawm cov tshuaj

Amoxiclav muaj ob lub ntsiab. Ua ntej tshaj plaws, qhov no yog semisynthetic penicillin - amoxicillin, thiab clavulanic acid. Txhua feem muaj nws tus kheej ua haujlwm. Amoxicillin yog ib qho ntawm cov tshuaj tua kab mob, txawm li cas los xij, clavulanic acid tsis muaj qhov pom kev tiv thaiv kab mob. Nws lub hom phiaj yog dabtsi?

Raws li koj paub, penicillins yog ib qho ntawm thawj cov tshuaj tua kab mob tau txais rov qab rau hauv nruab nrab ntawm lub xyoo pua xeem. Thaum lub sijhawm lawv siv, lawv tau pom lawv cov neeg siv khoom ntawd ntau. Tab sis tib lub sijhawm, ntau cov kab mob tswj kom txhim kho kev tawm tsam lawv. Cov kab mob tiv thaiv cov tshuaj tua kab mob ua haujlwm li cas?

Amoxicillin ua haujlwm ntawm cov xias ntawm cov kab mob, khi ib qho ntawm cov enzymes uas ua nws cov qauv. Raws li qhov tshwm sim, cov xovtooj ntawm phab ntsa poob nws lub zog, raug rhuav tshem thiab cov kab mob tuag. Txawm li cas los xij, ntau hom kab mob pib tsim cov tshuaj tshwj xeeb - beta-lactamases, uas thaiv qhov kev txiav txim ntawm cov tshuaj tua kab mob. Yog li, amoxicillin ua tsis muaj mob rau cov kab mob feem ntau.

Clavulanic acid tau tsim tshwj xeeb tsim los tawm tsam beta-lactamases. Los ntawm kev khi rau amoxicillin, nws ua rau cov tshuaj tua kab mob ua rau cov tshuaj tiv thaiv kab mob tiv thaiv tsis ua rau beta-lactamases. Cov nyhuv no yog manifested in relation to feem ntau ntawm cov beta-lactamases uas ua los ntawm cov kab mob.

Yog li, kev sib xyaw ua ke ntawm amoxicillin thiab clavulanic acid muaj qhov pom dav dav ntawm kev ua haujlwm tua kab mob dua li amoxicillin dawb huv. Yog tias amoxicillin tuaj yeem cuam tshuam tsuas yog tsawg tus kab mob uas tsis tuaj yeem tsim cov beta-lactamases, tom qab ntawd amoxicillin, ua ke nrog clavulanic acid, nquag tiv thaiv cov kab mob feem ntau uas ua rau kis mob. Ntawm cov kab mob uas Amoxiclav tuaj yeem rhuav tshem, muaj ob cov kab mob gram-zoo thiab gram-tsis zoo.

Lub ntsiab hom ntawm cov kab mob uas nkag siab rau Amoxiclav:

streptococci,
staphylococci,
Ntxaug Yaj
Klebsiella
brucella
echinococcus,
Helicobacter
clostridia
hemophilic bacillus,
salmonella
Kev ua Proteus.

Cov kab mob tiv thaiv Amoxiclav:

enterobacter
pseudomonads
mob chlamydia
mycoplasmas
legionella
Yersinia

thiab lwm qhov.

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog penicillin ib nrab hluavtaws ua haujlwm rau ntau yam kab mob gram-tsis zoo thiab gram-zoo. Nws inhibits cov biosynthesis ntawm peptidoglycan, ib qho khoom sib koom ua ke uas yog ib feem ntawm cov qauv ntawm cov kab mob ntawm tes phab ntsa. Kev txo qis ntawm cov peptidoglycan ua rau txo qis ntawm lub zog ntawm cov xovtooj ntawm tes, uas tom qab ntawd coj mus rau lysis thiab tuag ntawm cov hlwb ntawm pathogenic microorganisms. Nyob rau tib lub sijhawm, amoxicillin nkag siab rau kev ua ntawm beta-lactamases, uas rhuav tshem nws, yog li nws cov spectrum ntawm kev ua haujlwm tiv thaiv kab mob tsis suav nrog cov kab mob sib kis ua ke no enzyme.

Clavulanic acid yog beta-lactamase inhibitor, tus qauv ntawm uas zoo ib yam li penicillin. Nws muaj peev xwm tsis muaj peev xwm ua ntau yam beta-lactamases, uas tsim cov kab mob me me nrog kev ua pov thawj tsis kam rau cephalosporins thiab penicillins. Cov txiaj ntsig kev sib raug zoo ntawm clavulanic acid nyob rau hauv kev sib raug zoo nrog plasmid beta-lactamases, uas feem ntau txiav txim siab tias qhov tsis kam ntawm cov kab mob rau cov tshuaj tua kab mob, tau ua pov thawj. Txawm li cas los xij, cov tshuaj tsis ua raws li hom I chromosome beta-lactamases uas tsis raug txwv los ntawm clavulanic acid.

Muaj cov clavulanic acid hauv Amoxiclav tso cai tiv thaiv kev rhuav tshem ntawm amoxicillin los ntawm cov enzymes tshwj xeeb - beta-lactamases - thiab nthuav tawm cov kab mob kev tiv thaiv kab mob ntawm amoxicillin.

Cov kev tshawb fawb soj ntsuam hauv vitro ua pov thawj siab rhiab heev rau qhov kev txiav txim ntawm Amoxiclav ntawm cov kab mob hauv qab no:

gram-negative anaerobes: ntau hom ntawm genus Prevotella, Bacteroides fragilis, lwm yam ntawm cov genus Bacteroides, ntau yam ntawm genus Porphyromonas, ntau yam ntawm genus Capnocytophaga, ntau yam ntawm genus Fusobacterium, Fusobacterium nucleatum, Eikenella corrodens,
gram-positive anaerobes: hom noob genus Peptostreptococcus, Peptostreptococcus magnus, Peptostreptococcus micros, Peptococcus niger, hom noob genus Clostridium,
gram-negative aerobes: Vibrio cholerae, Bordetella pertussis, Pasteurella multocida, Haemophilus influenza, Neisseria gonorrhoeae, Moraxella catarrhalis, Helicobacter pylori,
gram-positive aerobes: coagulase-negative staphylococci (ua kom pom qhov mob rhiab rau methicillin), Staphylococcus saprophyticus (mob rhiab rau methicillin), Staphylococcus aureus (mob rhiab rau methicillin), Bacillus anthraciscc, Streptocococococcoco thiab lwm yam , Nocardia cov hnub qub, Listeria monocytogenes,
Lwm tus: Treponema pallidum, Leptospira icterohaemorrhagiae, Borrelia burgdorferi.

Cov kab mob hauv qab no yog tsiag ntawv los ntawm kev paub ua kom lub zog ntawm Amoxiclav:

gram-positive aerobes: streptococci ntawm Viridans pawg, Streptococcus pneumoniae, Enterococcus faecium, cov kab mob ntawm cov genus Corynebacterium,
gram-negative aerobes: cov kab mob ntawm cov genus Shigella, Escherichia coli, cov kab mob ntawm cov genus Salmonella, cov kab mob ntawm cov genus Klebsiella, Klebsiella pneumoniae (cov kev tshawb fawb soj ntsuam qhov ua tau zoo ntawm cov tshuaj nquag Amoxiclav txog kev tiv thaiv cov kab mob no, nws cov kab mob tsis ua ke ntawm beta-lactamases), kab mob Klebsi. , Proteus vulgaris, Proteus mirabilis.

Cov kab mob me hauv qab no qhia tau tias muaj qhov ntuj tsis haum rau amoxicillin thiab clavulanic acid:

Gram-tsis zoo aerobes: cov kab mob ntawm lub genus Acinetobacter, Yersinia enterocolitica, Citrobacter freundii, Stenotrophomonas maltophilia, cov kab mob ntawm lub genus Enterobacter, cov kab mob ntawm lub genus Pseudomonas, Hafnia alvei, cov kab mob ntawm lub genus Serratia, Legionella pneumophila, cov kab mob ntawm lub genus Providencia, Morganella morganii,
lwm yam: cov kab mob ntawm cov genus Mycoplasma, Chlamydophila psittaci, Chlamydophila pneumoniae, cov kab mob ntawm cov genus Chlamydia, Coxiella burnetii.

Qhov rhiab ntawm cov kab mob mus rau monotherapy nrog amoxicillin feem ntau txhais tau tias kev nkag siab zoo ib yam li kev sib xyaw ntawm amoxicillin thiab clavulanic acid.

Kev Ntsuam Xyuas Rau Neeg Mob

Victoria, Dnipropetrovsk. Siv raws li kws kho mob sau tseg los kho tus mob tonsillitis. Pom 5 hnub. Cov tshuaj tua kab mob pib rau hnub thib 3 mob. Tus kab mob subsided los ntawm ib feem peb. Kuv caj pas nres nres. Muaj mob raws plab, dhau li ntawm ob hnub, tom qab nws kuv pib noj cov tshuaj probiotics los kho cov microflora.

Alexandra, lub nroog Lugansk. Cov tshuaj no tau raug tshuaj los ntawm kws kho mob los kho tus mob pyelonephritis. Txoj kev kawm tau 7 hnub. Thawj 3 hnub hno - tom qab ntawd cov ntsiav tshuaj. Qhov hno no zoo dua. Txawm li cas los xij, kev txhim kho pib ncig hnub plaub. Tsis muaj kev mob tshwm sim. Puas yog qhov ncauj qhuav.

Tamara, lub nroog ntawm Boyarka. Lawv txhaj kuv cov tshuaj no rau kev kho mob kis mob rau poj niam. Nws mob heev, cov nqaij doog tseem nyob ntawm thaj chaw txhaj tshuaj. Txawm li cas los xij, tom qab ib lub lim tiam tsis muaj ib txoj kab tseem tshuav hauv lub luag nyav ntawm cov kab mob tseem ceeb.

Cov Ntaub Ntawv Ntxiv

Yog tias cov tshuaj tau siv ntev, nws yog ib qho tsim nyog los saib xyuas kev ua haujlwm ntawm tus neeg mob lub siab, cov ntshav cov ntshav thiab cov raum. Yog hais tias tus neeg mob tau kho lub raum lub siab, nws yog qhov tsim nyog yuav tau kho lub koob tshuaj lossis nce ntxiv lub sijhawm ntawm cov koob tshuaj ntawm cov tshuaj. Nws yog qhov zoo dua rau kev noj tshuaj nrog zaub mov. Thaum kis superinfection (qhov pom ntawm microflora tsis zoo rau cov tshuaj tua kab mob no), nws yog ib qho tsim nyog yuav tau hloov cov tshuaj. Vim tias qhov ua rau hla kev tsis haum nrog cephalosporins nyob rau hauv cov neeg mob rhiab rau penicillins, nws tsis tsim nyog siv cov tshuaj tua kab mob no ua ke.

Thaum noj tshuaj, koj yuav tsum haus kua ntau hauv cov kua thiaj li zam dhau qhov tsim ntawm amoxicillin muaju hauv cov zis.

Koj yuav tsum paub tias muaj cov koob tshuaj loj heev hauv cov tshuaj tua kab mob hauv lub cev tuaj yeem ua rau muaj qhov tsis zoo rau cov ntshav qabzib (yog Benedict reagent lossis Fleming's cov tshuaj siv los txiav txim rau nws). Cov txiaj ntsig zoo dua qub nyob rau hauv qhov no yuav muab kev siv cov tshuaj tiv thaiv enzymatic nrog glucosidase.

Txij li thaum cov kev mob tshwm sim los ntawm cov leeg muaj zog thaum siv yeeb tshuaj, nws yog qhov yuav tsum ua tib zoo tsav tsheb (tsheb) lossis koom nrog kev ua si uas yuav tsum muaj kev xav ntau, kev ceev nrawm thiab kev saib xyuas.

Nws yog tso rau ntawm lub hwj tshuaj.

Daim ntawv tso tawm	Nqe hauv Lavxias Lavxias	Nqe hauv Ukraine
Ncua kev kawm	280 rub	42 UAH
625 ntsiav tshuaj	370 RUB	68 UAH
Ampoules 600 mg	180 rub	25 UAH
Amoxiclav Quicktab 625	404 rub	55 UAH
1000 ntsiav tshuaj	440-480 rub.	90 UAH

Cov ntsiav tshuaj thiab kev daws rau qhov ncauj tawm

Qhov kev tswj hwm ntawm cov tshuaj thiab lub sijhawm ntawm kev kho yog txiav txim siab nyob ntawm qhov mob hnyav, lub hnub nyoog, tus neeg mob lub raum ua haujlwm thiab lub cev qhov hnyav. Hauv cov ntsiav tshuaj thiab kev ncua, Amoxiclav raug pom zoo kom noj nrog pluas noj, uas yuav txo qhov kev phom sij ntawm kev phiv los ntawm lub plab zom mov.

Qhov nruab nrab ntawm kev kho mob yog los ntawm 5-14 hnub. Kev kho ntev ntev yog ua tau tsuas yog tom qab kuaj mob zaum ob.

Cov koob tshuaj pom zoo rau Amoxiclav ntsiav tshuaj rau cov menyuam hnub nyoog qis dua 12 xyoos yog 40 mg / kg ib hnub, uas tau muab faib ua 3 koob. Cov menyuam yaus uas lub cev hnyav dua 40 kg tau pom tias cov neeg loj noj ntau dua ntawm cov tshuaj. Rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, nws yog qhov zoo dua kom siv Amoxiclav rho tawm.

Muaj ob lub qauv qhia txog kev siv tshuaj Amoxiclav rau cov neeg laus uas muaj mob me txog rau mob sib kis:

Txhua 8 teev, 1 ntsiav tshuaj 250 + 125 mg,
Txhua 12 teev, 1 ntsiav tshuaj 500 + 125 mg.

Tawm tsam keeb kwm yav dhau los ntawm kev kis mob hnyav thiab nrog tus mob ua pa nyuaj, 1 ntsiav tshuaj ntawm 500 + 125 mg yuav tsum noj txhua 8 teev lossis 1 ntsiav tshuaj ntawm 875 + 125 mg txhua 12 teev.

Nrog rau cov mob odontogenic, kev tswj hwm ntawm 1 ntsiav tshuaj ntawm Amoxiclav 250 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj ntawm 500 + 125 mg txhua 12 teev yog qhia rau 5 hnub.

Amoxiclav raug samfwm rau cov menyuam mos hnub nyoog tshiab thiab menyuam yaus txog li 3 hlis nyob rau hauv daim ntawv ntawm ncua kev kawm ntawv ntawm tus nqi ntawm 30 mg / kg ib hnub (raws li amoxicillin). Cov tshuaj tau noj nyob rau txhua 12 teev. Txhawm rau ua kom tsuas ntau npaum li cas, siv cov tshuaj pipette cov khoom xa nrog pob.

Kev noj tshuaj txhua hnub ntawm Amoxiclav rau menyuam yaus hnub nyoog qis dua 3 hlis yog:

Nrog rau mob sib khuav me me mus rau mob hnyav - ntawm 20 mg / kg ib hnub,
Hauv kev kis mob hnyav thiab hauv kev kho mob ntawm cov mob qis qis ntawm txoj hlab pa, otitis media, sinusitis - txog 40 mg / kg (amoxicillin) ib hnub.

Nws yuav tsum tau yug los rau hauv lub siab tias thaum suav kev suav tshuaj, ib qho yuav tsum tsis txhob cia siab rau lub hnub nyoog ntawm tus menyuam, tab sis ntawm qhov hnyav ntawm nws lub cev thiab qhov mob hnyav ntawm cov chav kawm ntawm tus kabmob.

Kev daws rau kev txhaj tshuaj

Amoxiclav nyob rau hauv txoj kev daws teebmeem rau kev txhaj tshuaj yog muab cov tshuaj pleev ib leeg nkaus.

Rau cov menyuam hnub nyoog qis dua 3 lub hlis, qhov tshuaj tau muab xam los ntawm cov lus qhia hauv qab no:

lub cev hnyav dua li 4 kg: Amoxiclav raug muab rau hauv 30 mg / kg (suav txog qhov hloov mus rau tag nrho cov tshuaj) txhua 12 teev,
lub cev hnyav dua 4 kg: Amoxiclav raug tswj ntawm 30 mg / kg (coj mus rau hauv tus lej hloov mus rau tag nrho cov tshuaj) txhua 8 teev.

Cov menyuam uas tsis tau ncav cuag 3 lub hlis uas muaj hnub nyoog, kev txhaj tshuaj yuav tsum tau muab tsuas yog maj mam ntxiv ua ntej 30-40 feeb.

Rau cov menyuam yaus lub cev qhov hnyav tsis tshaj 40 kg, qhov tshuaj tau xaiv raug txiav txim siab txog qhov hnyav ntawm lub cev.

Rau cov menyuam yaus txij li 3 hlis txog 12 xyoos, cov tshuaj tau muab rau 30 mg / kg lub cev qhov hnyav (hais txog tag nrho cov tshuaj) txhua 8 teev, thiab yog tias muaj mob hnyav, txhua 6 teev.

Hauv cov menyuam yaus uas kuaj pom tias lub raum tsis ua haujlwm lawm, yuav tsum tau txhaj tshuaj raws li qhov xav tau ntau tshaj ntawm amoxicillin. Yog tias nyob rau hauv cov neeg mob zoo li no creatinine kev tshem tawm ntau tshaj 30 ml / min, ib qho kev hloov pauv tau yog xaiv tau. Hauv lwm qhov xwm txheej, hauv cov menyuam yaus lub cev qhov hnyav tsis tshaj 40 kg, kev siv Amoxiclav hauv kev noj tshuaj hauv qab no raug pom zoo:

KK 10-30 ml / feeb: 25 mg / 5 mg rau 1 kg ntawm lub cev qhov hnyav txhua 12 teev,
CC tsawg dua 10 ml / feeb: 25 mg / 5 mg rau 1 kg ntawm lub cev qhov hnyav txhua 24 teev,
hemodialysis: 25 mg / 5 mg rau 1 kg ntawm lub cev qhov hnyav txhua 24 teev nyob rau hauv kev sib xyaw nrog ib koob tshuaj ntxiv ntawm 12.5 mg / 2.5 mg rau 1 kg ntawm lub cev qhov hnyav ntawm qhov kawg ntawm kev lim ntshav (cuam tshuam nrog kev poob qis ntawm cov clavulanic acid thiab amoxicillin hauv ntshav ntshav).

Txhua txhua 30 mg ntawm cov tshuaj muaj 25 mg ntawm amoxicillin thiab 5 mg ntawm clavulanic acid.

Rau cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg, Amoxiclav raug tshuaj rau ntau npaum li ntawm 1200 mg ntawm cov tshuaj (1000 mg + 200 mg) txhua 8 teev, thiab nyob rau kis tus mob kis tus kabmob sib kis - txhua 6 teev.

Amoxiclav kuj tseem raug samfwm rau kev phais mob hauv ib qho tshuaj prophylactic, uas feem ntau yog 1200 mg nrog qhov induction ntawm kev ua kom loog thaum muaj sijhawm ua haujlwm tsawg dua 2 teev. Nrog kev phais mob ntev dua, tus neeg mob tau txais cov tshuaj hauv 1200 mg txog 4 zaug rau 1 hnub.

Hauv cov neeg mob uas tau mob raum tsis ua haujlwm, qhov koob tshuaj thiab / lossis lub sijhawm ntawm lub sijhawm tswj hwm ntawm Amoxiclav yuav tsum kho raws li cov neeg tsis muaj zog lub raum ua haujlwm raws li cov lus qhia hauv qab no:

CC ntau dua 30 ml / min: tsis tas yuav tsum txhaj koob tshuaj,
KK 10-30 ml / min: thawj koob yog 1200 mg (1000 mg + 200 mg), tom qab ntawd cov tshuaj tau muab tso rau cov tshuaj ntawm 600 mg (500 mg + 100 mg) txhua 12 teev,
CC tsawg dua 10 ml / min: thawj koob tshuaj yog 1200 mg (1000 mg + 200 mg), tom qab ntawd cov tshuaj tau muab tso rau cov tshuaj ntawm 600 mg (500 mg + 100 mg) txhua 24 teev,
anuria: qhov luv nruab nrab ntawm kev txhaj tshuaj ntawm cov tshuaj yuav tsum tau nce mus rau 48 teev lossis ntau dua.

Txij li thaum lub sijhawm cov txheej txheem hemodialysis txog 85% ntawm kev siv tshuaj Amoxiclav raug muab tshem tawm, tom kawg ntawm txhua ntu, koob tshuaj ib txwm ntawm cov tshuaj yuav tsum tau muab. Nrog rau peritoneal lim ntshav, tsis tas yuav hloov cov koob tshuaj.

Lub sijhawm ntawm cov chav kawm ntawm kev kho mob yog los ntawm 5 mus rau 14 hnub (tsuas yog tus kws kho mob koom tuaj yeem txiav txim siab nws lub sijhawm). Nrog rau qhov txo qis hauv cov tsos mob hnyav, hloov mus rau hauv lub qhov ncauj ntawm Amoxiclav raug pom zoo raws li kev txuas ntxiv ntawm kev kho.

Thaum npaj cov tshuaj txhaj, cov ntsiab lus ntawm lub thauv hauv qhov ntau npaum li 600 mg (500 mg + 100 mg) tau yaj nyob rau hauv 10 ml dej rau kev txhaj, thiab hauv cov nyiaj 1200 mg (1000 mg + 200 mg) hauv 20 ml dej rau kev txhaj tshuaj (qhov ntim no tsis pom zoo tshaj). Cov tshuaj tau maj mam muab maj mam ncu (dhau 3-4 feeb), thiab kev qhia yuav tsum tau ua nyob rau hauv 20 feeb tom qab npaj ntawm kev daws.

Cov tshuaj Amoxiclav kuj tseem siv tau cov tshuaj leeg ntshav. Hauv qhov no, cov kev npaj daws teeb meem uas muaj 1200 mg (1000 mg + 200 mg) lossis 600 mg (500 mg + 100 mg) ntawm cov tshuaj tau diluted ntxiv nyob rau hauv 100 ml lossis 50 ml ntawm Txoj kev lis ntshav daws, feem. Lub sijhawm tiv thaiv ntawm Txoj kev lis ntshav nce mus txog 30-40 feeb.

Kev siv cov kua hauv qab no hauv qhov ntau ntau tso cai rau koj kom txuag tau qhov tsim nyog ntawm amoxicillin hauv kev daws teeb meem. Lawv lub sijhawm muaj kev sib txawv thiab ntau npaum li cas rau:

rau dej rau kev txhaj tshuaj: 4 teev ntawm 25 ° C thiab 8 teev ntawm 5 ° C,
rau kev daws teeb meem ntawm sodium chloride thiab calcium chloride rau kev tso ntshav infusion: 3 teev ntawm 25 ° C,
rau lub nplhaib cov tshuaj ntawm lactate rau cov leeg ntshav: 3 teev ntawm 25 ° C,
rau cov tshuaj sodium chloride 0.9% rau cov leeg ntshav: 4 teev ntawm 25 ° C thiab 8 teev ntawm 5 ° C.

Cov tshuaj Amoxiclav yuav tsum tsis txhob tov nrog sodium bicarbonate, dextran lossis dextrose cov kev daws teeb meem. Tsuas yog cov kev daws teeb meem kom pom tseeb xwb thiaj yog txoj cai. Qhov npaj tau daws yuav tsum tsis tau khov.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Yog tias thaum kho nrog tshuaj yaj yeeb tus neeg mob kuaj pom tias muaj qhov tsis txaus siab los ntawm lub hauv nruab nrab ntawm lub paj hlwb (piv txwv, qaug dab peg lossis dias taub hau), nws raug nquahu kom tsis txhob tsav tsheb thiab ua haujlwm uas yuav tsum muaj kev xav ntau ntxiv thiab cuam tshuam rau lub hlwb tam sim ntawd.

Cev xeeb tub thiab lactation

Hauv kev sim tsiaj, kev phom sij ntawm kev noj Amoxiclav thaum cev xeeb tub thiab cov nyhuv ntawm cov tshuaj rau kev loj hlob ntawm tus me nyuam hauv plab tsis tau paub tseeb. Hauv kev tshawb fawb ib leeg nrog cov poj niam nrog lub sijhawm ua ntej ntawm lub qog ua kua dej, nws tau pom tias prophylactic siv kev sib xyaw ntawm amoxicillin thiab clavulanic acid tuaj yeem ua rau muaj kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos.

Thaum cev xeeb tub thiab lactation, kev siv tshuaj Amoxiclav yog kev pom zoo tsuas yog tias muaj txiaj ntsig zoo ntawm kev kho mob rau leej niam tseem ceeb tshaj qhov txaus ntshai rau kev noj qab haus huv ntawm tus menyuam thiab menyuam. Clavulanic acid thiab amoxicillin hauv kev tso siab me me tau txiav txim siab hauv niam cov kua mis. Hauv cov menyuam mos uas noj niam mis, raws plab, hloov kho lub cev, mob hnyuv ntawm lub qhov txhab ntawm lub qhov ncauj yuav tshwm sim, yog li nws yuav tsum tau kho nrog tshuaj, nws yog ib qho zoo kom tsum tsis txhob pub niam mis.

Nrog lub raum tsis ua haujlwm

Cov neeg mob uas mob raum tsawg (CC txawv ntawm 10 txog 30 ml / min) qhia kom noj Amoxiclav 1 ntsiav tshuaj (koob 500 mg / 125 mg lossis 250 mg / 125 mg nyob ntawm tus mob hnyav) txhua 12 teev, thiab Kev mob raum tsis zoo (CC tsawg dua 10 ml / min) - 1 ntsiav tshuaj (koob 500 mg / 125 mg lossis 250 mg / 125 mg nyob ntawm qhov mob hnyav ntawm tus kabmob) txhua 24 teev.

Thawj koob tshuaj ntawm cov tshuaj rau kev tswj kav nrog CC ntawm 10-30 ml / min yog 1000 mg / 200 mg, tom qab ntawd 500 mg / 100 mg txhua 12 teev. Nrog CC tsawg dua 10 ml / min, thawj koob tshuaj ntawm cov tshuaj rau kev tswj kav yog 1000 mg / 200 mg, tom qab ntawd 500 mg / 100 mg txhua 24 teev.

Hauv anuria, lub sijhawm nruab nrab ntawm cov koob tshuaj ntawm Amoxiclav tau nce ntxiv rau 48 teev lossis ntau dua.

Yeeb tshuaj sib cuam tshuam

Kev nqus ntawm ascorbic acid ua ke nrog Amoxiclav txhim kho kev nqus ntawm nws cov tshuaj nquag, thiab kev nqus ntawm aminoglycosides, antacids, laxatives, glucosamine - txo lawv qhov nqus. Kev siv cov tshuaj tsis-steroidal los tiv thaiv cov tshuaj (NSAIDs), diuretics, phenylbutazone, allopurinol thiab lwm yam tshuaj uas thaiv cov leeg cov ntshav ua pa (probenecid) nce qib ntawm amoxicillin hauv lub cev (clavulanic acid yog feem ntau tawm ntawm kev muaj kab mob glomerular). Kev sib xyaw ntawm Amoxiclav thiab probenecid tuaj yeem ua rau nce ntxiv ntawm cov ntshav tsis tu ncua thiab cov ntsiab lus ntawm amoxicillin, tab sis tsis muaj clavulanic acid, yog li kev siv tshuaj ib txhij.

Kev sib xyaw ntawm amoxicillin, clavulanic acid thiab methotrexate txhim kho cov khoom lom ntawm methotrexate. Kev siv cov tshuaj ua ke nrog allopurinol tuaj yeem ua rau kev loj hlob ntawm cov tawv nqaij ua xua. Nws tsis pom zoo kom sau ntawv Amoxiclav nrog disulfiram.

Kev sib xyaw ntawm amoxicillin thiab clavulanic acid txo cov kev ua haujlwm ntawm cov tshuaj uas nws cov metabolism ua rau kev tsim cov para-aminobenzoic acid, thiab thaum noj nrog ethinyl estradiol, qhov kev pheej hmoo ntawm kev tsim "tawg" los ntshav nce ntxiv.

Hauv cov ntawv nyeem, muaj ob peb daim ntawv tshaj tawm txog kev nce qib hauv kev hloov pauv hauv thoob ntiaj teb (INR) hauv cov neeg mob nrog kev tswj hwm tib si ntawm amoxicillin thiab warfarin lossis acenocoumarol. Yog tias nws tsim nyog los sib txuas nrog Amoxiclav nrog cov tshuaj anticoagulants, yuav tsum tau soj ntsuam INR lossis prothrombin sijhawm tas li thaum pom zoo lossis pib kho nrog tshuaj, vim tias kev kho tshuaj tiv thaiv cov tshuaj anticoagulants noj ntawm qhov ncauj kuj yuav tsum tau siv.

Kev tswj hwm ntawm amoxicillin / clavulanic acid nrog rifampicin tuaj yeem ua rau kev sib txuam ua kom tsis muaj zog ntawm cov nyhuv antibacterial. Amoxiclav tsis pom zoo txawm tias ib zaug ua ke nrog cov tshuaj tua kab mob bacteriostatic (tetracyclines, macrolides) thiab sulfonamides vim qhov ntxim li yuav txo tau cov tshuaj amoxicillin / clavulanic acid.

Kev noj tshuaj txo qhov ua tau zoo ntawm kev tiv thaiv qhov ncauj. Hauv cov neeg mob noj mycophenolate mofetil, tom qab pib kho nrog Amoxiclav, muaj qhov txo qis hauv cov ntsiab lus ntawm cov metabolite nquag nyob hauv lub cev - mycophenolic acid - ua ntej noj cov tshuaj ntxiv ntawm kwv yees li 50%. Cov kev hloov pauv hauv nws cov kev sib txawv tsis tuaj yeem cuam tshuam txog qhov hloov pauv ntawm qhov cuam tshuam ntawm cov metabolite no.

Amoxiclav analogues yog:

Los ntawm cov tshuaj yeeb yam - Bactoclav, Clamosar, Arlet, Panklav, Medoklav, Liklav, Augmentin, Rapiklav, Fibell, Ekoklav, Amovikomb, Amoksivan,
Los ntawm cov tshuab ntawm kev ua - Libacil, Oxamp, Santaz, Ampioks, Tazotsin, Timentin, Sulacillin, Ampisid.

Tus nqi Amoxiclav hauv chaw muag tshuaj

Tus kwv yees tus nqi ntawm Amoxiclav nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog qhov ntau npaum 875 mg / 125 mg yog 4016436 rubles (14 ib pob), ntau npaum li 500 mg / 125 mg yog 330-399 rubles (15 ib pob), 250 mg / 125 mg - 170‒241 rubles (pob muaj 15 pcs.). Hmoov rau qhov kev npaj tawm ntawm kev ncua rau kev tswj hwm qhov ncauj nrog kev siv ntau npaum li 400 mg / 57 mg tuaj yeem yuav kwv yees li ntawm 158-232 rubles, ntau npaum li cas 250 mg / 62.5 mg rau 212-299 rubles, ntau npaum 125 mg / 31.25 mg - 99–123 rubles Cov. Hmoov rau qhov kev npaj rau kev txhaj tshuaj rau kev txhaj tshuaj nrog qhov tshuaj ntawm 1000 mg / 200 mg yuav raug nqi kwv yees 675-862 rubles, nrog ntau npaum ntawm 500 mg / 100 mg - 465-490 rubles (txhua pob muaj 5 lub raj mis).

Analogues ntawm cov tshuaj

Cov yam ntxwv tag nrho ntawm Amoxiclav suav nrog cov tshuaj muaj amoxicillin thiab clavulanic acid, piv txwv li, Augmentin, Flemoklav Solutab. Kev npaj muaj amoxicillin ib leeg yuav tsis hloov pauv tau vim hais tias cov npe ntawm cov kab mob me me hauv lub zog amoxicillin ntau me dua li ntawm Amoxiclav. Tib yam muaj peev xwm hais txog lwm yam tshuaj ntawm pawg penicillin - qhov tau txais ntawm lawv txoj kev siv tej zaum yuav tsis thooj rau cov kev txwv ntawm daim ntawv thov ntawm Amoxiclav.

Dosage daim ntawv

Zaj duab xis-coated ntsiav tshuaj

Cov tshuaj raum (qhov tseem ceeb): txhua ntsiav tshuaj 250mg + 125mg muaj 250 mg ntawm amoxicillin rau hauv trihydrate thiab 125 mg ntawm clavulanic acid nyob rau hauv daim ntawv ntawm cov ntsev ntsev,
txhua 500 mg + 125 mg ntsiav tshuaj muaj 500 mg ntawm amoxicillin nyob rau hauv daim ntawv ntawm trihydrate thiab 125 mg ntawm clavulanic acid nyob rau hauv daim ntawv ntawm cov ntsev potassium,
txhua 875 mg + 125 mg ntsiav tshuaj muaj 875 mg ntawm amoxicillin rau hauv daim ntawv ntawm trihydrate thiab 125 mg ntawm clavulanic acid nyob rau hauv daim ntawv ntawm poov tshuaj ntsev.
Excipients (feem rau txhua npaum): colloidal silicon dioxide 5.40 mg / 9.00 mg / 12.00 mg, crospovidone 27.40 mg / 45.00 mg / 61.00 mg, croscarmellose sodium 27.40 mg / 35.00 mg / 47.00, magnesium stearate 12.00 mg / 20.00 mg / 17.22 mg, talc 13.40 mg (rau kev noj tshuaj 250 mg + 125 mg), microcrystalline cellulose txog 650 mg / txog li 1060 mg / txog 1435 mg,
zaj duab xis txheej ntsiav tshuaj 250mg + 125mg - hypromellose 14.378 mg, ethyl cellulose 0.702 mg, polysorbate 80 - 0.780 mg, triethyl citrate 0.793 mg, titanium dioxide 7.605 mg, talc 1.742 mg,
zaj duab xis txheej ntsiav tshuaj 500mg + 125mg - hypromellose 17.696 mg, ethyl cellulose 0.864 mg, polysorbate 80 - 0.960 mg, triethyl citrate 0.976 mg, titanium dioxide 9.360 mg, talc 2.144 mg,
zaj duab xis txheej ntsiav tshuaj 875mg + 125mg - hypromellose 23.226 mg, ethyl cellulose 1.134 mg, polysorbate 80 - 1.260 mg, triethyl citrate 1.280 mg, titanium dioxide 12.286 mg, talc 2.814 mg.

Kev piav qhia

250 mg + 125 mg ntsiav tshuaj: dawb los yog yuav luag dawb, oblong, octagonal, biconvex, cov yeeb yaj kiab-nyias cov ntsiav tshuaj nrog 250/125 luam tawm ntawm ib sab thiab AMC ntawm lwm sab.
Cov ntsiav tshuaj 500 mg + 125 mg: dawb lossis yuav luag dawb, oval, biconvex ntsiav tshuaj, zaj duab xis-txheej.
875 mg + 125 mg ntsiav tshuaj: dawb los yog yuav luag dawb, oblong, biconvex, ntsiav tshuaj pleev xim rau zaj duab xis nrog kev nqis siab thiab kev xav ntawm "875/125" ntawm ib sab thiab "AMC" ntawm lwm sab.
Saib rau ntawm kink: daj kom loj.

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj
Mechanism ntawm kev ua
Amoxicillin yog penicillin ib nrab hluavtaws uas muaj kev ua haujlwm tiv thaiv ntau cov kab mob gram-positive thiab gram-tsis zoo. Amoxicillin cuam tshuam kev tsis sib haum xeeb ntawm biosynthesis ntawm peptidoglycan, uas yog cov txheej txheem sib cais ntawm cov kab mob ntawm phab ntsa. Kev ua txhaum ntawm cov synthesis ntawm peptidoglycan ua rau poob ntawm lub zog ntawm cov xovtooj ntawm phab ntsa, uas ua rau cov lysis thiab tuag ntawm cov kab mob hlwb. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.
Clavulanic acid, beta-lactamase inhibitor yam ntxwv ntawm kev siv rau penicillins, muaj peev xwm tsis muaj peev xwm tsis ua haujlwm ntau ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin resistant microorganisms. Clavulanic acid muaj kev ua tau zoo txaus los tiv thaiv plasmid beta-lactamases, uas feem ntau lub luag haujlwm tiv thaiv kab mob, thiab tsis muaj txiaj ntsig tawm tsam hom I chromosome beta-lactamases, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.
Muaj cov clavulanic acid nyob rau hauv kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.
Cov hauv qab no yog hauv kev ua haujlwm hauv vitro ntawm amoxicillin nrog clavulanic acid.

Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-zoo aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes thiab lwm yam beta-hemolytic streptococci 1,2, Streptococcus agalactiae 1,2, Staphylococcus aureus (rhiab rau methicillin), rhiab staphyloco rhiab rau methicillin).
Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.
Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Gram-zoo anaerobes: hom noob genus Clostridium, Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, hom tsiaj ntawm genus Peptostreptococcus.
Gram-negative anaerobes:
Bacteroides fragilis, hom genus Bacteroides, hom genus Capnocytophaga, Eikenella corrodens, Fusobacterium nucleatum, hom ntawm genus Fusobacterium, hom ntawm genus Porphyromonas, hom ntawm genus Prevotella.

Cov kab mob rau cov uas kis tau kuj yuav ntxim
rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-negative aerobes: Escherichia coli 1, Klebsiella oxytoca, Klebsiella pneumoniae, hom ntawm genus Klebsiella, Proteus mirabilis, Proteus vulgaris, hom ntawm genus Proteus, hom ntawm genus Salmonella, hom ntawm genus Shigella.
Gram-zoo aerobes: hom ntawm cov genus Corynebacterium, Enterosocus faecium, Streptococcus pneumoniae 1,2, streptococci ntawm pawg Viridans.

Ntxig Txawv Heev Kab Mob
rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-negative aerobes: hom ntawm genus Acinetobacter, Citrobacter freundii, hom tsiaj ntawm hom genus Enterobacter, Hafnia alvei, Legionella pneumophila, Morganella morganii, hom tsiaj ntawm Genus Providencia, hom kab mob genus Pseudomonas, hom kab mob genus Serratia, Stenotrophomonas maltophilia, Yersinia.
Lwm yam: Chlamydophila pneumoniae, Chlamydophila psittaci, hom tsiaj ntawm tus kab mob Chlamydia, Coxiella burnetii, hom kab mob genus Mycoplasma.
1 rau cov kab mob no, kev kho mob ua tau zoo ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid tau ua kom pom hauv kev tshawb fawb.
2 hom ntawm cov kab mob no tsis tsim cov beta-lactamases. Kev nkag siab nrog amoxicillin monotherapy qhia zoo ib yam li kev nkag siab zoo rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Cov Tshuaj Pharmacokinetics
Lub ntsiab pharmacokinetic tseem ceeb ntawm amoxicillin thiab clavulanic acid yog qhov zoo sib xws. Amoxicillin thiab clavulanic acid yaj tau zoo nyob rau hauv cov kev daws teeb meem nrog lub cev pH thiab, tom qab noj Amoxiclav ® sab hauv, tau nrawm thiab ua kom tiav los ntawm kev mob plab (GIT). Qhov nqus ntawm cov tshuaj nquag ntawm amoxicillin thiab clavulanic acid yog qhov zoo dua yog tias noj thaum pib noj mov.
Lub bioavailability ntawm amoxicillin thiab clavulanic acid tom qab kev tswj hwm qhov ncauj yog li 70%.
Cov tshuaj tso cai ntawm amoxicillin thiab clavulanic acid tau muab rau hauv qab no tom qab kev tswj hwm ntawm 875 mg / 125 mg thiab 500 mg / 125 mg ob zaug ib hnub, 250 mg / 125 mg peb zaug ib hnub los ntawm cov neeg ua haujlwm noj qab haus huv zoo.

Qhov nruab nrab (± SD) pharmacokinetic tsis muaj
Ua yeeb yam tshuaj Amoxicillin / clavulanic acid	Ib Leeg koob tshuaj (mg)	Cmax (mcg / ml)	Tmax (teev)	AUC (0-24h) (mcg.h / ml)	T1 / 2 (teev)
Amoxicillin
875 mg / 125 mg	875	11,64±2,78	1.50 (1.0-2.5)	53,52±12,31	1.19±0.21
500 mg / 125 mg	500	7,19±2,26	1.50 (1.0-2.5)	53,5±8,87	1.15±0.20
250 mg / 125 mg	250	3,3±1,12	1,5 (1,0-2,0)	26,7±4,56	1,36±0,56
Clavulanic acid
875 mg / 125 mg	125	2,18±0,99	1.25 (1.0-2.0)	10,16±3,04	0.96±0.12
500 mg / 125 mg	125	2,40±0,83	1.5 (1.0-2.0)	15,72±3,86	0.98±0.12
250 mg / 125 mg	125	1,5±0,70	1,2 (1,0-2,0)	12,6±3,25	1.01±0,11

Сmax - siab tshaj plaws ntshav concentration,
Tmax - lub sijhawm kom mus txog cov ntshav siab tshaj plaws,
AUC yog thaj chaw hauv qab nkhaus "concentration-sijhawm",
T1 / 2 - ib nrab-lub neej

Kev xa Khoom
Ob qhov sib xyaw ua ke muaj cov cim zoo ntawm kev faib tawm hauv ntau yam plab hnyuv siab raum, cov ntaub so ntswg thiab lub cev ntawm lub cev (suav nrog rau hauv lub ntsws, cov plab hnyuv ntawm lub plab hauv plab, adipose, pob txha thiab cov leeg nqaij, pleural, synovial thiab peritoneal kua, nyob rau hauv daim tawv nqaij, bile, zis, pus. kev tso tawm, hnoos qeev, hauv cov kua dej interstitial).
Plasma protein khi yog mob pes tsawg: 25% rau clavulanic acid thiab 18% rau amoxicillin.
Kev faib khoom yog kwv yees 0.3-0.4 L / kg rau amoxicillin thiab txog 0.2 L / kg rau clavulanic acid.
Amoxicillin thiab clavulanic acid tsis hla cov ntshav-hlwb teeb meem hauv kev tsis txaus ntshai.
Amoxicillin (zoo li feem ntau penicillins) raug tso tawm hauv niam cov kua mis. Ib co kua nplaum ntawm clavulanic acid kuj tau pom nyob rau hauv niam cov kua mis. Amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv hniav.
Kev zom zaub mov
Kwv yees li 10-25% ntawm thawj zaug koob tshuaj amoxicillin yog raug tawm los ntawm lub raum hauv daim ntawv ntawm tsis ua pa penicilloic acid. Clavulanic acid nyob rau hauv tib neeg lub cev muaj kev tsim cov metabolism hauv hnyav nrog kev tsim ntawm 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid thiab 1-amino-4-hydroxy-butan-2-ib thiab raug tshem tawm los ntawm lub raum, los ntawm lub plab zom mov, nrog rau lub tshuab pa tawm, nrog rau cov pa roj carbon dioxide.
Chaw Sau Ntawv
Amoxicillin tsuas yog tawm los ntawm lub raum, thaum clavulanic acid los ntawm ob lub raum thiab ntxiv cov tshuab. Tom qab cov tshuaj noj ib qhov ncauj ntawm ib ntsiav tshuaj ntawm 250 mg / 125 mg lossis 500 mg / 125 mg, kwv yees li 60-70% ntawm amoxicillin thiab 40-65% ntawm clavulanic acid raug tshem tawm tsis hloov pauv los ntawm lub raum thaum thawj 6 teev.
Qhov nruab nrab ib nrab-lub neej (T1 / 2) ntawm amoxicillin / clavulanic acid yog kwv yees li ib teev; qhov ntsuas qhov nruab nrab tag nrho yog kwv yees li 25 l / teev hauv cov neeg mob noj qab haus huv.
Qhov ntau tshaj plaws ntawm clavulanic acid tau tawm hauv thawj 2 teev tom qab kev coj noj coj ua.
Cov neeg mob uas lub raum tsis ua hauj lwm zoo
Tag nrho kev tshem tawm ntawm amoxicillin / clavulanic acid txo qis hauv kev faib ua feem kom txo qis kev ua haujlwm ntawm lub raum. Kev txo qis hauv kev tshem tawm yog tshaj tawm rau amoxicillin dua rau clavulanic acid, vim tias feem ntau ntawm amoxicillin yog ua tawm los ntawm lub raum. Kev noj tshuaj ntawm cov tshuaj rau lub raum tsis ua haujlwm yuav tsum tau xaiv coj mus rau hauv qhov kev xav tsis tau txog kev khaws cia ntawm amoxicillin thaum tswj hwm qhov ib txwm muaj ntawm clavulanic acid.
Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo
Hauv cov neeg mob uas lub siab tsis ua hauj lwm, tshuaj tau siv nrog ceev faj, nws yog ib qho tsim nyog los soj ntsuam daim siab ua haujlwm tas li.
Ob qho kev sib xyaw ua ke raug tshem tawm los ntawm hemodialysis thiab cov khoom me me los ntawm peritoneal lim ntshav.

Siv thaum cev xeeb tub thiab thaum pub niam mis

Cov kev tshawb fawb tsiaj tsis tau qhia txog cov kev phom sij ntawm kev noj tshuaj thaum cev xeeb tub thiab nws cov nyhuv ntawm kev loj hlob hauv cov menyuam hauv plab.
Hauv ib txoj kev tshawb nrhiav rau cov poj niam nrog kev puas tsuaj ua ntej ntawm lub qog ua kua dej, nws tau pom tias prophylactic siv amoxicillin / clavulanic acid yuav cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos.
Thaum cev xeeb tub thiab lactation, cov tshuaj tsuas yog siv yog tias lub hom phiaj muaj txiaj ntsig rau leej niam tshaj qhov ua rau muaj kev pheej hmoo rau tus menyuam thiab menyuam.
Amoxicillin thiab clavulanic acid hauv ib qho me me txeem mus rau hauv niam cov kua mis.
Hauv cov menyuam mos tau txais kev pub niam mis, kev txhim kho ntawm kev xav rhiab, raws plab, zais plab ntawm lub plab ntawm lub qhov ncauj ua tau. Thaum noj Amoxiclav ®, nws yog qhov tsim nyog los txiav txim siab txog kev txiav kev pub mis niam.

Sab sij huam

Raws li Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO), tsis xav txog cov teebmeem raug cais raws li lawv qhov kev loj hlob raws li hauv qab no: feem ntau (/1 / 10), feem ntau (/1 / 100, los ntawm kev mob plab hnyuv
heev heev: zawv plab
feem ntau: xeev siab, ntuav. Xeev siab yog feem ntau pom thaum noj cov koob tshuaj zoo.
Yog tias kev ua txhaum ntawm lub plab zom mov tau paub tseeb, lawv tuaj yeem tshem tawm yog tias koj noj cov tshuaj thaum pib noj mov.
pheej: lub plab zom mov
Tsis tshua muaj: muaj cov tshuaj tua kab mob (nrog rau mob ua rau mob plab thiab mob ua paug), tus nplaig “plaub” dub, mob ncauj plab, mob plab.
Ntawm ib sab ntawm daim siab thiab cov hnyuv
pheej: kev ua si ntau ntxiv ntawm alanine aminotransferase (ALT) thiab / lossis aspartate aminotransferase (AST). Cov kev tawm tsam no tau pom nyob hauv cov neeg mob tau txais kev kho mob beta-lactam, tab sis nws qhov tseem ceeb ntawm cov kab mob tseem tsis tau paub txog.
Tsis tshua muaj: cholestatic jaundice, mob siab, nce kev ua si ntawm alkaline phosphatase, kev ua haujlwm ntawm bilirubin ntau ntxiv hauv cov ntshav ntshav.
Cov kev tsis zoo tshwm sim los ntawm daim siab raug pom muaj feem ntau hauv cov txiv neej thiab cov neeg laus laus thiab tuaj yeem cuam tshuam nrog kev kho mob ntev. Cov kev mob tshwm sim no tsis tshua pom muaj hauv cov menyuam yaus.
Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, txawm li cas los xij qee zaum qee zaum lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Kev phiv tshuaj yog feem ntau thim rov qab.
Cov kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, nyob rau qhov xwm txheej tsis tshua muaj neeg paub txog kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg uas muaj mob hnyav nrog lub cev lossis cov neeg tau txais cov tshuaj hepatotoxic ib txhij.
Los ntawm lub cev tiv thaiv kab mob
tsis tshua muaj: angioedema, anaphylactic ua haujlwm, kev tsis haum tshuaj vasculitis,
Ntawm ib feem ntawm cov ntshav thiab lymphatic system
tsis tshua muaj: thim rov qab cov leukopenia (suav nrog neutropenia), thrombocytopenia,
tsis tshua muaj: thim rov qab agranulocytosis, hemolytic anemia, thim rov qab nce nyob rau hauv lub sijhawm prothrombin, thim rov qab nce lub sijhawm los ntshav (saib Ntu "Cov Lus Qhia Tshwj Xeeb"), eosinophilia, thrombocytosis.
Los ntawm lub paj hlwb tawg
pheej: kiv tob hau, mob taub hau,
tsis tshua muaj: cov leeg mob (tuaj yeem tshwm sim hauv cov neeg mob uas lub raum tsis ua haujlwm, zoo li thaum noj tshuaj ntau dua), thim rov qab, kev mob hlwb, mob siab, pw tsaug zog, hloov cwj pwm, ntxhov siab.
Ntawm feem ntawm daim tawv nqaij thiab cov nqaij mos
pheej: daim tawv nqaij xoo pob liab vog, pruritus, urticaria,
tsis tshua muaj: erythema multiforme exudative,
tsis tshua muaj: exfoliative dermatitis, Stevens-Johnson syndrome, mob dav dav exanthematous pustulosis, mob ib yam li kev mob ntshav siab, mob ua paug rau cov leeg ntshav.
Los ntawm ob lub raum thiab lub plab
tsis tshua muaj: interstitial nephritis, crystalluria (saib ntu "Overdose"), hematuria.
Kis tau thiab kis kab mob
feem ntau: candidiasis ntawm daim tawv nqaij thiab mucous daim nyias nyias.
Lwm yam
tsis paub zaus: kev loj hlob ntawm cov kab mob ua tsis tau zoo.

Chaw tsim tshuaj paus

Nrog RU: Lek dd, Verovshkova 57, 1526 Ljubljana, Slovenia,
Nws yog tsim: Lek dd, Perzonali 47, 2391 Prevale, Slovenia.
Tus neeg thov cov neeg tau txais kev pab yuav tsum xa mus rau ZAO Sandoz:
125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.