Emoxipin - cov lus qhia rau kev siv thiab tso tawm daim ntawv, muaj pes tsawg leeg, noj ntau npaum li cas, cim thiab tus nqi

Emoxipine (INN - Emoxipine) yog angioprotector uas txo cov theem ntawm permeability ntawm cov vascular phab ntsa vim qhov ua kom nrawm ntawm cov txheej txheem dawb radical, kuj tseem siv tshuaj yaj yeeb yog antioxidant thiab antihypoxantCov. Emoxipin yuav txo cov ntshav viscosity, vascular phab ntsa permeability, thiab txoj kev nyiam ua rau cov leeg ntshav. Tsis tas li ntawd, cov tshuaj ua kom nquag plias ntawm cov tshuaj yuav ua rau kom nce qib ntawm cyclic nucleotides hauv cov nqaij mos ntawm lub hlwb thiab cov ntshav ntshav.

Fibrinolytic kev ua ntawm cov tshuaj yog manifested nyob rau hauv qhov tseeb hais tias nyob rau hauv cov ntaub ntawv ntawm ib tug mob lub sij hawm plawv nres, cov txheej txheem muaj peev xwm nthuav cov hlab ntsha hlab ntsha, thiaj li dhau qhov ua kom pom tseeb necrosisCov. Tsis tas li, lub peev xwm conductive thiab kev cog lus ntawm lub plawv yuav raug txhim kho.

Raws li cov tshuaj ophthalmic, Emoxipin muaj cov khoom ua haujlwm retinoprotective, nws tiv thaiv lub retina los ntawm qhov kev ua ntawm lub teeb ci loj. Ncos ntawm Emoksipin yuav pab daws txoj leeg ntshav ntswg thiab txhim kho cov txheej txheem microcirculation hauv qhov muag.

Pharmacodynamics thiab pharmacokinetics

Cov Tshuaj Hauv Tshuaj

Muaj nuj nqi zoo rau ntshav coagulation: los ntawm kev txo qhov zuag qhia tag nrho coagulation index thiab txo platelet aggregation, cov tshuaj lengthens lub sijhawm ntshav coagulation sijhawm. Cov ntawv ua hnoos qeev ntawm cov hlwb thiab cov hlab ntsha hauv qab qhov kev txiav txim ntawm cov tshuaj ua kom nyob tus yees, cov ntshav liab nce lawv tiv mus rau hemolysis thiab cov neeg kho tshuab raug mob.

Ua tau zoo inhibition ntawm dawb-radical oxidation ntawm lipids muaj nyob hauv biomembranes. Ntxiv kev ua si ntawm cov enzymes ua lub luag haujlwm rau antioxidant. Muaj peev xwm muab tau lipid-tej nyhuv los ntawm kev txo cov synthesis ntawm triglycerides.

Txais tos ntawm Emoksipin yog tuaj yeem txo qhov kev nthuav qhia cerebral hemodysfunctionCov. Nws muaj cov txiaj ntsig zoo ntawm kev ruaj khov ntawm lub cerebral cortex mus ischemia thiab hypoxiaCov. Kho autonomic dysfunctions nyob rau hauv kev mob ntawm cerebrovascular kev huam yuaj.

Emoxipin muaj cov lus hais tawm cardioprotective. Kev tiv thaiv cov hlab plawv yuav tiv thaiv yog tias myocardial ischemic raug mob: Cov yeeb tshuaj txwv nws muab faib, kuj nthuav lub zog rau cov hlab ntshav.

Li a qhov muag tee Emoxipin tiv thaiv qhov retina los ntawm qhov kev puas tsuaj vim qhov kev sib kis ntawm lub teeb ci loj. Tsis tas li ntawd xwb, vim tias cov tshuaj, resorption ntawm hemorrhages sab hauv qhov muag yog ua tau.

Cov Tshuaj Pharmacokinetics

Tus neeg mob koob tshuaj 10 mg rau 1 kg ntawm tus neeg mob qhov hnyav, tus nqi qis heev yuav tsum muaj sau tseg ib nrab kev tshem tawm ntawm cov tshuajCov. Kev tshem tawm tas li yog 0.041 min, qhov pom tseeb ntawm qhov kev faib tawm yog 5.2 l, kev tshem tag nrho yog 214,8 ml ib feeb.

Cov tshuaj sai sai rau hauv cov kabmob thiab cov nqaij hauv tib neeg lub cev thiab nws yog qhov tshwm sim meej meej metabolism hauv.

Cov tshuaj pharmacokinetics ntawm Emoxipin tuaj yeem sib txawv raws li cov neeg mob lub cev. Piv txwv, qhov muaj cov kab mob pathological lub cev muaj zog occlusion, kev ceev ceev uas cov tshuaj tawm hauv lub cev yuav raug txo kom tsawg, kom nws ua ntau dua bioavailable.

Cov xwm txheej ntawm retrobulbar tswj hwm ntawm Emoxipin, cov tshuaj ua haujlwm hauv cov tshuaj tshwm sim tam sim ntawd nyob rau hauv cov ntshav, cov qib siab ruaj khov nyob ntev li ob teev, thiab tom qab 24 teev tom qab kev tswj hwm, kab ntawm kev tswj hwm yuav luag tsis tiav hauv cov ntshav. Ib qho tseeb ntawm cov tshuaj yog khaws cia hauv lub qhov muag cov ntaub so ntswg.

Kev qhia rau kev siv Emoxipin

Li a qhov muag tee qhia txog kev siv yog:

• txoj leeg ntshav ntswg,
• mob ntsws vwm nyob rau hauv nruab nrab hlab ntsha ntawm lub retina ntawm lub qhov muag thiab nws cov ceg,
• mob ntsws,
• retina tiv thaiv tom qab laser coagulation thiab lub teeb siv loj dua (nyob rau hauv cov ntaub ntawv ntawm cov tshuaj tiv thaiv tshav ntuj thiab laser hlawv).

Kev ntsuas rau siv Emoxipin kev txhaj tshuaj:

Tsis tas li, Emoxipin txhaj tshuaj yog siv rau hauv cov ntaub ntawv ntawm mob ntev thiab mob circulatory mob cuam tshuam ntawm lub hlwbyog tias qhov ua rau cov kev tsis zoo no yog hemorrhagic thiab ischemic ntshawv siab. Yog tias tsim nyog, cov tshuaj tuaj yeem raug txhaj tshuaj raws li kev txhaj tshuaj hauv qhov nqaij, lossis los ntawm kev txhaj tshuaj rau hauv ampoules.

Sab sij huam

Kev phiv tshuaj tuaj yeem tshwm sim arousaluas tom qab lub sijhawm luv luv ntawm lub sijhawm yuav hloov tsaug zogCov. Tej zaum nce ntshav siab thiab tsos ua pobCov. Cov kev tawm tsam hauv zos tuaj yeem pom los ntawm qhov mob, khaus, kub hnov, liab thiab ua kom nruj ntawm cov ntaub so ntswg mob.

Cov lus qhia rau kev siv Emoxipin (Txujci thiab ntau npaum li cas)

Cov lus qhia rau Emoxipin - tee qhov muag

Nyob rau hauv cov ntaub ntawv ntawm retrobulbar tswj hwm ntawm cov tshuaj, ib feem pua ​​kev daws teeb meem nyob rau hauv tsuas tshuaj ntawm 0.5 ml yog muab 1 lub sij hawm nyob rau ib hnub rau 10-15 hnub. Yog tias cov tshuaj raug muab tshuaj subconjunctival thiab parabulbar, tom qab ntawd los ntawm 0.2 mus rau 0.5 ml ntawm cov tshuaj tau siv ib zaug ib hnub rau 10-30 hnub.

Yog tias nws yog qhov tsim nyog los tiv thaiv ocular retina, cov tshuaj tau muab rov qab rau hauv retrobulbarly nyob rau hauv qhov ntau npaum ntawm 0.5 ml ib hnub thiab ib teev ua ntej laser coagulation. Lub chav kawm yog nyob ntawm qhov ntsuas ntawm kev kub hnyiab tau txais thaum lub sijhawm laser coagulation, feem ntau, tee yog thov retrobulbarly ib zaug ib hnub los ntawm ob txog kaum hnub.

Cov lus qhia rau Emoxipin - kev txhaj tshuaj

Hauv kev mob plawv thiab txoj hlab hlwb, cov tshuaj siv tshuaj feem ntau yog ua rau lub cev nrog ib tee dej ntawm tus nqi ntawm 20-40 tee ib feeb. Cov koob tshuaj ntawm cov tshuaj yog 20-30 ml ntawm peb feem pua ​​kev daws. Droppers tuaj yeem muab los ntawm ib zaug mus rau peb zaug hauv ib hnub rau 5-15 hnub. Lub sijhawm kho yog nyob ntawm hom mob ntawm tus neeg mob. Thaum kawg ntawm cov qaug dej, lawv hloov mus rau kev txhaj tshuaj intramuscular ntawm cov tshuaj: 3-5 ml ntawm cov tshuaj 3% yog txhaj 2-3 zaug hauv ib hnub. Lub sij hawm ntawm kev txhaj tshuaj intramuscular yog los ntawm 10 mus rau 30 hnub.

Emoxipin tsis raug tso tawm hauv ntsiav tshuaj daim ntawv, vim tias koj tsis tuaj yeem noj cov tshuaj Emoxipin, vim tias lawv tsuas tsis muaj nyob xwb.

Noj ntau dhau

Yog tias muaj kev noj tshuaj ntau dhau, qhov tshwm sim lossis sib zog ntawm cov kev mob tshwm sim muaj peev xwm ua tau. Nrog rau kev noj tshuaj ntau dhau hwv lossis siv tshuaj yeeb yaj kiab, nws yuav nce ntxiv ntshav siabntxhov siab ntev dhau los lossis tsaug zog, mob lub siab, mob taub hau, xeev siabmob plab tsis xis nyob. Ntshav coagulation tej zaum yuav tsis txawj.

Kev kho mob ntawm kev noj tshuaj tshaj ntawm Emoxipin thiab kev noj tshuaj ntawm Emoxipin yog kom tsis txhob haus tshuaj thiab ua cov txheej txheem ntawm kev kho mob, yog tias tsim nyog.

Kev sib txuam

Cov ntaub ntawv ntawm daim ntawv thov ua ke nrog α-tocopherol acetate, tej zaum qhov ua tau tshwm sim ntau dua ntawm cov antioxidant zog ntawm Emoxipin. Feem ntau, kev noj tshuaj tsis pom zoo kom ua ke nrog kev siv lwm yam tshuaj yam tsis tau txais kev tso cai los ntawm tus kws kho mob.

Cov Tshuaj Pharmacokinetics

Thaum muab ntawm koob tshuaj 10 mg / kg, lub sijhawm ib nrab ntawm kev tshem tawm Ti / g yog 18 feeb, tag nrho kev tshem tawm ntawm CI yog 0.2 l / min, thiab qhov pom meej ntim ntawm kev faib tawm ntawm Vd yog 5.2 l.

Cov tshuaj sai sai rau hauv cov kabmob thiab cov ntaub so ntswg, qhov uas nws tau tso thiab metabolized. Tsib metabolites ntawm emoxipin, sawv cev los ntawm dealkylated thiab conjugated khoom ntawm nws txoj kev hloov pauv, tau pom. Emoxipin metabolites yog ua tiav los ntawm lub raum. Cov teeb meem loj ntawm 2-ethyl-6-methyl-3-hydroxypyridine-phosphate muaj nyob hauv daim siab.

Hauv cov kab mob pathological, piv txwv li, nyob rau hauv rooj plaub ntawm mob coronary occlusion, pharmacokinetics ntawm emoxipin hloov. Qhov kev tshem tawm tus nqi txo, lub sijhawm siv ntawm emoxipin hauv cov hlab ntsha nce ntxiv, uas yuav yog vim nws rov qab los ntawm qhov khoom, nrog rau los ntawm ischemic myocardium.

Hnub tas sij hawm

3 xyoos txij li hnub tso tawm.

Emoxipin yog qhov kev kho mob niaj hnub no uas zoo tshaj plaws. Nws tsuas yog drawback yog qhov muaj zog hauv zos kev khaus thaum siv. Cov tib neeg ntsib cov kab mob ophthalmic hnyav los ntawm kev tshuaj xyuas zoo txog Emoxipine, vim tias lawv nruj ua raws li kws kho mob cov lus qhia thiab, vim qhov teeb meem loj heev, pom tseeb tias yuav tsum tau kho. Yog tias cov tshuaj siv rau kev kho mob ntawm cov mob ophthalmic me, tom qab kev tshuaj xyuas txog cov tee yuav tsis zoo li: qhov tseeb yog tias tsis yog txhua tus neeg npaj txhij ua rau muaj qhov tsis txaus siab rau lub sijhawm kub hnyiab tom qab noj cov tshuaj.

Cov kws kho mob rov tshuaj xyuas txog qhov muag tee - zoo heev. Cov tshuaj tawm tsam nrog nws txoj haujlwm, txawm hais tias nws ua rau kev tsis xis nyob ib ntus hauv cov neeg mob.

Emoxipin Kev Txhaj Tshuaj zoo tiv thaiv kev cuam tshuam ntawm cov mob nkees thiab mob plawv nres hauv ntau cov neeg mob thoob ntiaj teb. Tsis tas li, kev noj cov tshuaj nyob rau lub sijhawm luv luv yuav pab txo ntau yam kev mob ntawm cov leeg hlwb. Nws yog qhov tsim nyog tias kev zoo li ntawm kev siv tshwm sim hauv kev tshuaj xyuas zoo, ob leeg los ntawm cov neeg mob thiab los ntawm cov kws kho mob.

Emoxipin nqi, qhov twg yuav

Koj tuaj yeem yuav Emoxipin hauv Kiev yam tsis muaj teeb meem: cov tshuaj lossis cov tshuaj analogues muaj peev xwm nrhiav tau hauv yuav luag txhua txhua lub tsev muag tshuaj. Tias tsuas yog tus nqi yuav txawv me ntsis nyob ntawm lub tsev muag tshuaj, txawm li cas los xij, yuav luag txhua qhov muag muag hauv Ukraine, thiab lwm yam tshuaj sib txawv ntawm tus nqi. Nws nyob tsis yog tsuas yog nyob ntawm npoo ntawm lub tsev muag tshuaj ntawm cov tshuaj, tab sis kuj nyob ntawm qhov chaw ntawm nws ntau lawm, tso tawm ntau, thiab lwm yam.

Tus nqi nruab nrab qhov muag tee emoxipin 1% hauv lub 5 ml lub raj mis hloov pauv hauv khw ncig 60 UAH. Pob ntawm tsib ampoules 1 ml ntawm ib feem pua ​​Emoksipin No. 10 yuav raug nqi kwv yees li 50 UAH hauv ib lub tsev muag tshuaj.

Muaj pes tsawg leeg ntawm Emoxipin

Cov tshuaj tiv thaiv kab mob tshuaj (antiplatelet) tau nthuav tawm ua ob hom: cov tshuaj tiv thaiv qhov muag thiab muaj kev daws teeb meem rau kev tswj hwm hauv tsoomfwv. Lawv qhov txawv:

Cov kua ntshiab tsis muaj kua

Qhov kev kub siab ntawm ethylmethyloxypyridine hydrochloride, g ib ml

Cov dej ua kom huv, sodium sulfite anhydrous, disodium phosphate dihydrate

Ampoules ntawm 1 lossis 2 ml, 5 pcs. hauv ib pob nrog cov lus qhia rau kev siv

5 ml vials nrog tus xa dej