Dab tsi yog thiab leej twg xav tau Insulin Humalog?

Ib lub rooj sib tham ntawm cov kws tshaj lij ntawm kev siv ntawm kev siv npaj txhij-ua kom tsis txhob muaj cov tshuaj insulin Humalog Mix 50 hauv kev kho mob hom 2 mob ntshav qab zib mellitus (T2DM) tau tshwm sim. Nyob hauv lub tswv yim ntawm cov kws tshaj lij sab laj lub rooj sib tham, cov teeb meem ntawm kev ua tiav glycemic tswj tau zoo hauv cov neeg mob uas muaj ntshav qab zib hom 2 thiab cov chaw kho mob ua tau zoo thiab cov kev siv ntawm cov tshuaj tiv thaiv insulin sib xyaw tau tham txog. Raws li ib feem ntawm kev sib tham, muaj peev xwm ua tiav lub hom phiaj ntawm kev kho mob rau cov neeg mob ntshav qab zib hom 2 nrog kev pab ntawm Humalog Mix 50 insulin, kev taw qhia tshwj xeeb thiab contraindications, nrog rau kev ua kom zoo ntawm kev soj ntsuam ntawm cov neeg mob tau txais kev kho mob insulin nrog qhov ua tiav Humalog Mix 50 insulin sib xyaw tau txiav txim siab.

Cov ntsiab lus: hom 2 mob ntshav qab zib mellitus, insulin, npaj sib tov sib xyaw, lispro, Humalog Mix 50.

Lub rooj sib tham ntawm pawg kws tshaj lij rau kev siv tshuaj ua ntej siv cov tshuaj insulin npaj Humalog Mix 50 hauv hom 2 ntshav qab zib mellitus

Lub vaj huam sib luag ntawm cov kws tshaj lij tau muaj kev sib tham txog kev ua haujlwm zoo thiab kev siv dag zog ntawm kev tswj glycemic los ntawm kev npaj ua ntej cov tshuaj insulin npaj hauv T2DM. Kev saib xyuas tshwj xeeb tau them rau cov kev kho mob nrog Humalog Mix 50, suav nrog kev ntsuas thiab contraindications, muaj peev xwm ua tiav ntawm cov hom phiaj kho thiab ua kom zoo ntawm kev saib xyuas neeg mob.

Cov ntsiab lus: ntshav qab zib mellitus hom 2, insulin, ua ntej sib xyaw, lispro, Humalog Mix 50

Tsis pub dhau lub moj khaum ntawm pawg kws tshaj lij, cov ntawv ceeb toom ntawm Kev Koom Tes Koom Tes ntawm Lavxias Academy ntawm Medical Science M.V. Shestakova txog cov teeb meem ntawm kev ua tiav glycemic tswj tau zoo hauv cov neeg mob T2DM thiab S.V. Elizarova ("Eli Lilly") ntawm kev soj ntsuam kev ua tau zoo ntawm kev siv kev ua tiav ntawm kev sib xyaw ntawm cov tshuaj insulin Humalog Mix 50 thiab cov txheej txheem rau nws siv.

Qhov kev sib tham tau tsom mus rau qhov chaw kho mob thiab qhov ua tau ntawm kev ua tiav lub hom phiaj ntawm kev kho mob ntawm cov neeg mob ntshav qab zib hom 2 nrog kev pab ntawm Humalog Mix 50 insulin, cov keeb kwm ntawm cov neeg mob uas tau pom kev kho mob no nrog Humalog Mix 50 insulin sib xyaw, thiab cov chaw kho mob siv tshuaj.

Hauv nws daim ntawv tshaj tawm, M.V. Shestakova tau sau tseg tias txhua txhua xyoo tus naj npawb ntawm cov neeg mob kev txom nyem los ntawm T2DM thiab kev noj tshuaj insulin los ua ntau dua, txawm li cas los xij, nyob rau hauv qhov kev soj ntsuam tseem ceeb, lub hom phiaj glycemic tsis tau tiav. Ib qho laj thawj rau qhov no yog qhov tsis txaus pib ntawm kev siv tshuaj insulin. Yog li, raws li CREDIT txoj kev tshawb nrhiav, qhov pib ntawm kev siv tshuaj insulin tshwm sim ntawm HbA1c theem ntawm 9.7%. Txoj kev tshawb nrhiav ACHIEVE (A1chieve Program hauv tebchaws Russia: ntau tus neeg ua haujlwm dhau los ua kev soj ntsuam ntawm kev ua tau zoo thiab kev nyab xeeb ntawm kev pib thiab kev siv tshuaj insulin nrog insulin analogues hauv cov neeg mob ntshav qab zib hom 2 uas yav dhau los tsis tau txais insulin hauv kev kho mob niaj hnub) qhia tau tias hauv cov neeg mob pib pib hauv paus cov tshuaj insulin, theem ntawm HbA1c yog 9.7%, thiab los ntawm cov khoom sib xyaw npaj - 10.1%, nrog kev kho mob bolus (BBT) - 10.4%. Hauv txhua qhov ntxim nyiam, qhov no yog vim hais tias cov kws tsim tshuaj endocrinologist muaj kev xav zoo tias kev kho tshuaj insulin yuav tsum tau pib ntawm HbA1c theem siab tshaj 9%.

Nrog rau qhov no, feem ntau, qhov tsis ntev pib ntawm kev siv tshuaj insulin yog qhov tsim nyog los ntawm qhov kev xav tsis zoo los ntawm cov neeg mob ntawm cov txheej txheem kev kho mob insulin nws tus kheej thiab lawv tsis raug ntawm lub ntsiab lus ntawm kev siv tshuaj insulin. Tib lub sijhawm, cov kws kho mob feem ntau muaj kev txhawj xeeb txog qhov tshwm sim muaj peev xwm ntawm cov kev mob tshwm sim ntawm kev kho mob insulin, xws li kev pheej hmoo ntawm hypoglycemia thiab qhov hnyav hauv cov neeg mob. Nws yuav tsum raug sau tseg tias cov kev thaiv uas tshwm sim hauv cov neeg mob hloov pauv nrog kev pib kho mob. Yog li, kev kawm los ntawm F.J. Snoek li al. , qhia pom tias hauv cov neeg mob uas twb tau txais insulin, qhov kev xav tsis zoo ntawm cov txheej txheem ntawm kev kho tshuaj insulin yog txo piv nrog cov neeg mob insulin-naive. Qhov no yeej nce siab rau lo lus nug ntawm qhov xav tau rau kev qhia ua haujlwm zoo rau cov neeg mob ntshav qab zib, txij li los ntawm kev ua kom muaj peev xwm ntawm cov neeg mob, suav nrog kev paub ntxiv txog lawv tus kab mob, nws muaj peev xwm txo cov teeb meem kev kho mob kom raws sij hawm thiab siv tshuaj kho mob insulin.

Kev xav tau kev tswj hwm glycemic nruj tsis tas yuav tsum tau pib kho cov tshuaj insulin tsis raws sij hawm, tab sis kuj tseem xaiv cov tshuaj insulin kom tsim nyog thiab siv tau, tswj kev ua tiav lub hom phiaj qhov tseem ceeb ntawm glycemia.

Muaj ntau txoj hauv kev pib thiab pib kho mob ntawm cov tshuaj insulin. Raws li ADA / EASD cov lus pom zoo, cov neeg mob uas tsis tau them nqi rau kev kho lub qhov ncauj hypoglycemic feem ntau yog siv tshuaj insulin basal. Thaum glycemic tswj lub hom phiaj tsis tiav lossis nws tsis tuaj yeem tswj nrog cov kev kho tam sim no, ntxiv cov insulin tsis muaj zog. Kev kho mob nrog cov khoom siv npaj tau suav yog suav tias yog lwm txoj hauv kev pib thiab sib zog ntawm kev siv tshuaj insulin. Hauv cov lus pom zoo hauv Lavxias, tsis zoo li ADA / EASD cov lus pom zoo, cov khoom sib xyaw npaj tau siv ob qho tib si thaum pib ntawm kev siv tshuaj insulin, nrog rau cov insulin basal, thiab raws li qhov muaj zog ntxiv nrog rau cov insulin ntawm insulin. Cov kev xaiv ntawm kev kho mob insulin yog nyob ntawm, ua ntej txhua yam, ntawm qib glycemia, kev ua raws li kev kho mob thiab tus neeg mob lub neej.

Sib tham txog cov ntsiab lus tseem ceeb ntawm kev ua tiav kev tswj ntshav qab zib kom zoo, cov kws tshaj lij tau hais tias qhov kev xav tshaj plaws ntawm cov neeg endocrinologist pib kho cov tshuaj insulin nyob rau ntawm HbA1c theem ntawm 9% yuav cuam tshuam nrog cov algorithm uas teeb tsa qhov ntsuas no rau cov neeg mob T2DM hauv kev pib kho cov piam thaj, uas qhov tshuaj insulin yog thawj cov tshuaj. Cov kws tshaj lij tau hais kom xav tau qhov tseeb ntawm cov hom phiaj glycemic, txij li nws muaj peev xwm ua kom tus kheej cuam tshuam cov hom phiaj thoob plaws ntiaj teb ntawm kev kho. Tsis tas li ntawd, yuav tsum muaj kev hloov kho cov txheej txheem ntau dua ntawm cov txheej txheem rau kev kho kom haum xeeb rau kev kho cov kua qab zib kom tsawg rau cov neeg mob T2DM. Hais txog cov teeb meem ntawm kev ua tiav lub hom phiaj ntawm txoj kev kho nyob rau hauv kev sib koom tes ntawm cov neeg mob uas tau txais kev kho mob insulin, cov kws tshaj lij tau txiav txim siab tias cov tshuaj insulin kho mob yuav tsum tau muaj kev txhawb nqa, uas yog, kev tshuaj xyuas nws tus kheej ntawm glycemia, kev suav ntawm cov khoom noj carbohydrates noj hauv kev noj zaub mov thiab kev txhim kho cov tshuaj insulin muab rau noj, txwv tsis pub, nws tsis ua txiaj ntsig.

Ib txoj hauv kev ua tiav kev tswj cov tshuaj metabolism hauv T2DM yog kev qhia rau kev soj ntsuam kev xyaum ntawm cov tshuaj insulin niaj hnub nrog kev txhim kho pharmacokinetic thiab pharmacodynamic zog, tso cai rau koj xaiv cov tshuaj tua kab mob insulin zoo tshaj plaws coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob. Cov tshuaj ua ntej insulins nrog kev sib piv ruaj ruaj ntawm luv luv thiab ntev ua yeeb yam insulins, uas yog qhov zoo tshaj plaws thiab siv tau rau cov neeg mob uas xav tau qhov yooj yim thiab yooj yim rau cov tshuaj insulin kho mob, tau siv dav hauv kev kho mob ntawm cov neeg mob ntshav qab zib hom 2.

Humalog Mix 50 yog qhov tshiab hauv Lavxias npaj-ua kom sib xyaw ua ke ntawm cov tshuaj insulin uas muaj cov tshuaj insulin lispro thiab nws cov kev txwv tsis pub tshuaj nyob rau hauv qhov sib piv ntawm 50:50. Qhov nruab nrab ntawm kev nqis tes ua ntev yog muab los ntawm kev txwv tsis pub ncua ntawm lispro insulin (50%), uas ua raws li lub hauv paus zais cia ntawm insulin, thiab insulin lispro (50%) yog ib qho kev ua haujlwm ntawm ultrashort uas txo cov glycemia tom qab noj mov. Cov tshuaj no ua ke nrog kev yooj yim ntawm kev siv thiab cov yam ntxwv tshwj xeeb ntawm kev ua ntawm ultrashort kev txiav txim ntawm Humalog tshuaj.

Cov kws tshaj lij tau soj ntsuam cov txiaj ntsig kev soj ntsuam los sib piv Humalog Mix 50 insulin nrog cov txheej txheem: insulin glargine ib zaug ib hnub thiab peb koob tshuaj lyspro insulin ua ntej cov zaub mov tseem ceeb hauv cov neeg mob T2DM, nrog kev tswj tsis tau glycemic thaum kho nrog insulin glargine thiab qhov ncauj hypoglycemic tshuaj. Lub hom phiaj tseem ceeb ntawm txoj kev tshawb no yog ua kom pom qhov ua tau zoo ntawm insulin lyspro sib xyaw 50 hauv kev sib piv nrog lub hauv paus bolus regimen ntawm txoj kev kho. Hauv qhov kev kawm, qhov kev txwv tsis tau ncav cuag qhov pov thawj qhov sib npaug ntawm Humalog Mix 50 npaj cov tshuaj insulin sib xyaw nrog kev sib piv nrog cov txheej txheem bolus regimen, tab sis kev ua tau zoo ntawm cov kev cai no tau qhia nyob rau hauv lub hauv paus ntawm cov ntaub ntawv tau txais los txo qis glycated hemoglobin, uas qhov nruab nrab tshaj pawg 1 , 87% ntawm tus nqi pib, thaum nruab nrab HbA1c hauv tag nrho pawg yog 6.95% nrog lub hom phiaj HbA1c ntawm 7.0%. Nyob rau tib lub sijhawm, hauv cov pab pawg ntawm cov neeg mob tau txais insulin glargine ua ke nrog kev tswj hwm peb zaug ntawm lyspro insulin ua ntej cov zaub mov tseem ceeb, qhov txo qis glycated hemoglobin yog 2.09% thiab nce mus txog qhov nruab nrab ntawm 6.78% hauv pawg. Nws tau sau tseg tias ntau dua 80% ntawm cov neeg mob hauv ob pawg tau ua tiav HbA1c lub hom phiaj ntawm 7.5%. Qhov feem ntawm cov neeg mob uas ua tiav HbA1c ntawm 7.0% yog 69% hauv pawg pab pawg-bolus thiab 54% hauv Humalog Mix 50 pawg.

Thaum sib tham txog qhov zaus ntawm cov tshuaj tiv thaiv hypoglycemic, nws tau sau tseg tias ob hom ntawm insulin txoj kev kho yog sib npaug nyab xeeb. Ob qho tag nrho cov nquag ntawm hypoglycemia thiab zaus ntawm nocturnal thiab mob ntshav qab zib heev tsis txawv hauv cov pab pawg.

Cov txiaj ntsig tau nthuav tawm cov kev sim tshuaj pom tau hais tias qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv Humalog Mix 50 ua lwm txoj hauv kev los ntawm BBT, cov kws tshaj lij tau lees paub tias qhov chaw kho mob tseem ceeb thiab txiav txim siab tias cov tshuaj Humalog Mix 50 tej zaum yuav muaj nyob rau hauv kev xav ntawm Lavxias kev ua lag luam, nthuav kev muaj peev xwm ntawm tus endocrinologist hauv kev xaiv qhov zoo tshaj plaws tshuaj insulin txoj kev kho mob uas tso cai rau ua kom tus neeg siv tau kev kho mob.

Cov kws tshaj lij pom zoo siv cov tshuaj ua ib feem ntawm cov ntawv sau npe coj los kho tus neeg mob ntshav qab zib uas xav tau kev kho mob insulin.

Thaum lub sijhawm sib tham, cov kws txawj tau soj ntsuam ntau yam ntawm cov neeg mob uas muaj ntshav qab zib hom 2, rau cov uas tswj hwm cov tshuaj insulin Humalog Mix 50 yuav yog qhov zoo tshaj plaws xaiv:

• - raws li lwm txoj hauv kev kho mob basal-bolus kev siv tshuaj tua kab mob insulin rau cov neeg mob uas tsis yooj yim los ua ntau yam kev txhaj tshuaj ntawm ob hom tshuaj insulin thiab tsis muaj peev xwm los ua cov kev rov qab saib xyuas tus kheej tas li ntawm glycemia, tsim nyog rau kev muaj txiaj ntsig ntawm kev kho qhov pib-bolus,
• - rau cov neeg mob uas xav tau cov tshuaj insulin rau kev kho mob ntawm kev yoo mov thiab kev tiv thaiv kab mob glycemia, tab sis nrog cov hom phiaj tsis muaj kev kho ntau dhau - HbA1c 7.5% lossis ntau dua,
• - rau cov neeg mob uas tsis tau them nyiaj rau hauv kev npaj cov tshuaj insulin sib xyaw (30/70 thiab 25/75) hauv kev tswj hwm ntawm 2-pawg tswj hwm (thaum sawv ntxov thiab ua ntej noj hmo), vim tias muaj ntshav qabzib ntau ntxiv (BCP), uas yuav tsum tau txhaj ntxiv cov tshuaj insulin ua haujlwm kom tswj tau. BCP tom qab noj su. Rau cov neeg mob zoo li no, Humalog Mix 50 nyob rau hauv kev tswj hwm ntawm 3 tshuaj nyob rau ib hnub yuav yog cov tshuaj yooj yooj yim thiab yooj yim uas tsis tas yuav ntxiv qhov tshuaj thib ob ntawm insulin,
• - rau cov neeg mob uas tsis tau them nyiaj rau cov qis insulin, nrog BCP loj vim tias siv cov khoom noj muaj cov khoom noj nplua nuj nyob hauv carbohydrates, thiab tsis npaj hloov mus rau lawv tus cwj pwm,
• - rau cov neeg mob uas tau txais lub hauv paus-bolus kev kho mob ntawm cov tshuaj insulin hauv qhov sib piv ntawm 50% ntawm qhov pib tiv thaiv thiab 50% ntawm qhov kev qhuas, txawm li cas los xij, lawv yuav tsum tau piv rau cov txheej txheem ntawm kev kho mob insulin, piv txwv li, thaum tus neeg mob tawm hauv tsev kho mob mus rau kev kho mob sab nraud.

Lub Humalog Mix 50 insulin pib thiab titration regimen kuj tau suav tias yog ib feem ntawm pawg kws tshaj lij. Kev noj tshuaj txhua hnub thiab tus naj npawb ntawm kev txhaj tshuaj ntawm hom insulin no yog txiav txim siab los ntawm tus neeg mob xav tau ntawm tus neeg mob, nws txoj kev ua neej, kev noj haus thiab phiaj glycemia. Yog tias Humalog Mix 50 yog lwm txoj hauv kev rau basal-bolus regimen ntawm insulin txoj kev kho thiab yuav yog lub kauj ruam tom ntej tom qab basal insulin, tom qab ntawd tag nrho cov tshuaj txhua hnub ntawm basal insulin uas tus neeg mob tau txais ua ntej tau muab faib ua peb qhov sib luag thiab qhia ua Humalog Mix 50 ua ntej cov zaub mov tseem ceeb Cov. Txawm li cas los xij, kev siv tshuaj insulin tuaj yeem pib ob qho tib si nrog ib tug txhaj rau hauv cov pluas noj loj tshaj plaws, thiab nrog 2 thiab 3 hno ib hnub. Tom qab ntawd, txoj kev them ib feem kaum ntawm kev txhaj tshuaj ntawm txhua ntawm peb qhov kev txhaj tshuaj no tshwm sim rau tus nqi uas ua kom tiav qhov kev ua tiav ntawm cov hom phiaj kho kho glycemic. Hauv kev siv tswv yim, nws yog ib qho tseem ceeb kom nco ntsoov tias Humalog Mix 50 khaws tag nrho cov khoom ntawm Humalog insulin, thiab nws siv tau ob qho tib si ua ntej ua ntej noj mov, thiab thaum thiab noj mov, uas txhim kho tus neeg mob lub neej zoo.

Xav pom qhov cuam tshuam ntawm Insulin Humalog

Cov tshuaj hormones insulin cais:

• los ntawm lub sijhawm ntawm lawv qhov kev txiav txim - ntev, nruab nrab, luv luv, ultrashort, lub sijhawm ntev thiab ua ke,
• los ntawm keeb kwm ntawm lub active tshuaj - nqaij npuas thiab nws cov semisynthetic derivatives, txhob kaw cov tib neeg thiab nws hloov kho hloov tshiab.

Insulin Humalog yog lub npe muaj tswv yim rau cov Fabkis hom ntawm cov tshuaj nrog cov tshuaj nquag Lizpro (Insulin lispro) - cov roj ntsha tso tawm los ntawm cov tshuaj hormones uas ua los ntawm beta hlwb ntawm tib neeg cov txiav ua ke. Nws tsuas yog qhov txawv ntawm lub ntuj tsim los ntawm tib neeg insulin lawm yog kev rov ua dua ntawm proline (Zauv 28) thiab lysine (No. 29) amino acid seem hauv nws cov lwg me me.

Xws li cov sib txawv tau tsim los ntawm kev txhob txwm. Ua tsaug rau nws, Insulin Humalog thiab nws cov lus zoo tuaj yeem siv ob qho tib si los ntawm cov neeg mob ntshav qab zib hom 1, txhawm rau kev qoj ib ce thauj tsis txaus, thiab cov neeg mob ntshav qab zib hom 2, uas cov qog ntawm tes tau tsim insulin tsis kam (tiv thaiv kab mob) rau lawv tus kheej insulin lawm.

Cov tshuaj insulin - qhov kev thauj mus los uas "qhib" lub xovtooj ntawm tes rau qabzib

Kev noj tshuaj monopreparations nrog cov gene-recombinant Lizpro rau cov tshuaj insulin cov tshuaj ua haujlwm ntawm ultrashort. Lub sijhawm cia rau lub caij nplooj zeeg hauv kev mloog zoo ntawm cov piam thaj hauv cov ntshav ntshav yog 10-20 feeb tom qab tswj hwm hauv qab daim tawv. Qhov siab tshaj plaws lub ncov yuav pom nyob hauv 1 txog 3 teev, thiab tag nrho lub sijhawm ntawm cov nyhuv hypoglycemic yog 3-5 teev.

Rau cov ntaub ntawv. Cov neeg mob ntshav qab zib uas paub txog "insulin-dependant" paub txog, thiab "cov pib" yuav tsum nco ntsoov tias kev txhaj tshuaj tiv thaiv kab mob ultrashort yuav cuam tshuam rau cov neeg laus thiab menyuam yaus - tom qab 10 feeb, yog tias koj nkag rau hauv qab tawv nqaij hauv qab plab, thiab tom qab 20 feeb, yog tias txhaj tshuaj ua hauv lub xwb pwg. Txawm li cas los xij, lub sijhawm ntawm qhov cuam tshuam yog tus kheej ntshiab, thiab yuav hloov pauv thaum lub sijhawm.

Lub tswv yim tseem ceeb ntawm kev ua yog kev tswj hwm kev noj cov zaub mov carbohydrate-lipid metabolism thiab kev pab hauv kev siv cov piam thaj los ntawm cov cell, vim rov qab ua tiav ntawm cov qog nyiaj ntawm cov tshuaj insulin uas ploj lawm, tsis muaj qhov no qhov tseem ceeb ntawm lub zog (cov piam thaj) tsis tuaj yeem nkag los ntawm cov cell qog rau hauv lawv nruab nrab.

Ntxiv rau kev nqus ntawm cov piam thaj thiab txo qis nws cov kev xav hauv ntshav ntshav, Insulin Humalog muaj cov teebmeem hauv qab no:

• nce qib ntawm fatty acids, glycerol thiab glycogen nyob rau hauv lub hlwb ntawm pob txha pob txha,
• tsub kom zus tau tej cov protein tebchaw,
• kawm ua ntu siv cov amino acids,
• lowers tus nqi ntawm glycogenolysis thiab gluconeogenesis.

Rau ib daim ntawv. Los ntawm txoj kev, piv nrog tib neeg cov kev sib xyaw ua kom tiav cov roj ntsha insulin cov tshuaj lom neeg, cov neeg kawm tiav qib qis hauv hyperglycemia tom qab noj mov nrog Lizpro Insulin yog qhov tseeb dua.

Txhua qhov kev npaj tshuaj insulin yog siv tawm tsam ntawm keeb kwm ntawm kev noj haus thiab nws cov txwv 1700-3000 kcal

Cov ntsiab lus, contraindications, phiv thiab lwm yam nuances

Cov kev qhia rau yeeb tshuaj Insulin Humalog muaj cov khoom nram qab no:

• Cov Lus Qhia - T1DM, T2DM, mob ntshav qab zib hauv lub cev, mob ntshav qab zib subulinaneous insulin tsis kam, tiv thaiv tsis tau tus mob tom qab tau mob siab, koom nrog tus kabmob uas ua rau mob ntshav qab zib tsis txaus, thiab phais mob rau tus neeg mob ntshav qab zib.
• Contraindications - hyperglycemic tej yam kev mob, nce tus neeg rhiab.
• Kev phiv - ib ntus insulin lens presbyopia, insulin o thiab cov tsos mob hypoglycemic xws li:
  1. mob taub hau
  2. tsis txawv ntawm lub cev tawv nqaij,
  3. tawm hws, nce ntau hws ua hws,
  4. lub plawv dhia thiab plawv dhia
  5. lim hiam ua rau lub cev, mob nqaij ntshiv, tus ntsav myoclonic, cov kab mob sib kis thiab ntau yam paresis,
  6. txo qis hauv kev txawj ntse lub luag haujlwm,
  7. pw tsaug zog
  8. ntxhov siab.

Glucagon txhaj tshuaj yuav tsum yog nyob rau hauv ib tus neeg xub pab khoom mob ntshav qab zib

• Overdose - hypoglycemic precoma thiab coma. Cov mob no nres los ntawm subcutaneous lossis intramuscular tswj ntawm glucagon. Yog tias tsis muaj ib qho yeeb tshuaj twg lossis los ntawm nws txoj kev siv cov nyhuv xav tau tsis xav tau, kev txhaj tshuaj thaum muaj xwm txheej ceev ntawm cov kua nplaum tiav rau hauv txoj hlab ntshav tau ua.
• Ceev faj. Hauv cov neeg mob uas muaj teeb meem lub raum thiab mob siab, thaum lub cev hnyav dhau los ua lub cev, thaum tsis muaj carbohydrates hauv zaub mov, thiab hauv kev kho mob beta-blockers, sulfonamides lossis MAO inhibitors, thaum noj cov cawv lossis haus cawv muaj yeeb tshuaj, qhov xav tau ntawm cov tshuaj yuav tsis tshua suav daws. Ua kom tau koob tshuaj ntau dua yuav tsum tau muaj thaum kis mob, thaum lub siab ntsws, thaum noj zaub mov noj, thaum kho thiazide diuretics, tshuaj tiv thaiv kab mob hauv qhov ncauj, tricyclo-antidepressants thiab glucocorticosteroids.
• Tsuas tshuaj Lizpro (Humalog) pleev cov tawv nqaij, los ntawm 4 rau 6 zaug ib hnub. Ib koob tshuaj, ntau npaum li cas thiab lub sijhawm ntawm txhua qhov kev txhaj tshuaj yog xaiv los ntawm tus kws endocrinologist. Ib koob txhaj nrog ib koob tshaj 40 PIECES yog tso cai tsuas yog tshwj xeeb. Thaum hloov mus rau Lizpro monotherapy nrog ceev nrawm ua yeeb yaj kiab nqaij hlav noj nqaij, yuav tsum tau hloov kho ntau npaum li cas. Thaum lub sij hawm xa khoom thiab tam sim ntawd tom qab nws, qhov ntau ntawm cov tshuaj raug pom zoo kom txo qis. Ib leej niam cov menyuam uas tseem noj mis uas muaj ntshav qab zib kuj tseem xav tau koob tshuaj thiab / lossis hloov kev noj haus.
• Nta ntawm kev cia khoom thiab siv. Kev npaj tshuaj insulin yuav tsum muab cia rau hauv qab txee ntawm lub tub yees. Ua ntej kev tswj hwm, qhov koob tshuaj "ua kom sov", dov nws ntawm lub xib teg ntawm 10 txog 20 npaug. Kev saib xyuas kuj yuav tsum tau ua tib zoo xyuas kom meej tias kev txhaj tshuaj tsis nkag mus rau hauv cov hlab ntshav.

Ceeb Toom! Nrog kev qhia ntawm kev npaj txias, yog tias dej cawv tau txais hauv qab daim tawv nqaij, lossis tsuas yog vim nws qhov txiaj ntsig anabolic hauv zos, ib qho tshuaj pleev ib ce (lipohypertrophy) tuaj yeem tsim, uas txo cov kev nqus ntawm cov tshuaj. Yog li ntawd, thaum txhaj, koj yuav tsum tau hloov qhov chaw tas li ntawm qhov kev txhaj tshuaj, thiab thaum tho hauv ib qhov chaw, piv txwv li, ntawm lub plab, tawm qhov deb ntawm 1 cm ntawm lawv.

Cov Sib Txawv Sib Txawv Humalog Mix 50 thiab Mix 25 los ntawm ultrashort Humalog

Hauv kev npaj ua ke Humalog ntxiv rau 6 tus neeg

Insulin Humalog Mix 50 thiab Insulin Humalog Mix 25 yog cov neeg sawv cev ntawm kev sib koom ua ke ntawm cov tshuaj insulin. Lawv yog cov sib xyaw ntawm kev daws ntawm ultrashort Lizpro nrog kev tiv thaiv tshuaj tiv thaiv ntawm Lizpro, uas hais txog cov tshuaj hormones ntawm nruab nrab. Qhov sib piv ntawm cov tshuaj no hauv Mix yog 50 - 1 txog 1, thiab hauv Mix 25 - 1 txog 3.

Kev ceev ntawm qhov pib ntawm kev ua rau txhua tus Humalogs yog qhov qub, tab sis lub sijhawm ntawm lub ncov (qhov siab tshaj plaws nyob rau hauv cov ntshav cov ntshav) yog qhov txawv, thiab vim muaj cov protamin Lizpro tivthaiv, qhov kev txiav txim ntawm insulin profile tau ntev. Ua tsaug rau qhov no, 3-2 hno ib hnub ntawm MIX50 lossis 2-1 kev txhaj tshuaj ntawm MIX25 yuav txaus rau qee tus neeg mob.

Cov yam ntxwv ntawm kev siv kev ua ke ua ke Humalog

Cartridge thiab ib qho ntawm Quick Pen-injector ntau yam

Cov kws kho mob ntshav qab zib uas tau txhaj tshuaj sib xyaw ua ke ntawm Insulin Humalog, vim qhov tseeb tias cov tshuaj tiv thaiv Lizpro nyob rau hauv kev ua rau kev ncua, thiab muaj kev zam nyob rau hauv kev npaj, tsis tsuas yog yuav tsum tau noj tshuaj ua kom sov ua ntej kev txhaj tshuaj, tab sis cov kev tiv thaiv raws li nram no yuav tsum nruj saib xyuas:

• tig rov qab cov kua los ntawm tig lub taub hau los yog rab koob xaum 180 degrees,
• tus naj npawb ntawm lem - 10-12 zaug,
• qhov ceev thiab qhov ntawm txav tau yog tus, txog 1 tig hauv ib thib ob,
• ceev faj ntawm cov tsos ntawm npaus, uas yuav tsum xav txog hauv koob tshuaj txo,
• Yog tias koj hnov ​​lub suab nrov thaum yws yws, tsis txhob ntshai thiab tsis txhob tshee tshuaj rau qhov tsis txaus siab - txhua lub cartridge lossis tus cwj mem nrawm muaj cov pob me me uas pab sib xyaw txhua yam tshuaj.

Tseem Ceeb! Yog tias, tom qab yws yws, qhov kev npaj ua ke tsis tau txais qhov tsis zoo ntawm cov npluav rog xws li mis nyuj, tab sis plaub ya tshwm, nws yog txwv tsis pub siv xws li npaj.

Cov kev cai rau siv QuickPen Syringe Cwjmem

Yog tias khawm tau nruj nreem rau hauv txhua txoj cai ntawm cov txheej txheem kev qhia, hloov daim ntawv xaum xim nrog lub tshiab

Tam sim no, ob qho tib si huv si ultra-luv Insulin Humalog, thiab kev sib xyaw ua ke ntawm Humalog Mix-50 thiab Humalog Mix-25, muaj nyob hauv qhov yooj yim reusable syringe cwjmem.

Thaum siv cov khoom siv yooj yim no, cov cai thiab kev ceev faj yuav tsum ua raws:

• tsis txhob tso koj cov xwj rau lwm cov ntshav qab zib,
• rau txhua txoj kev txhaj tshuaj tom ntej, noj tsuas yog ib qho tshiab Becton Dickinson & C rab koob,
• tsis txhob siv cov xaum xiam uas tsis zoo, thiab ib txwm nqa lub tshuab thib ob nrog koj, uas yuav siv tau thaum muaj "nrhiav" sai sai ntawm cov khoom tsis txaus uas xav tau rau ib qho kev txhaj,
• tsis pom kev rau cov neeg mob ntshav qab zib rau txhaj tshuaj nrog tus cwj mem xav tau kev pab ntawm cov neeg tuaj yeem pom nws zoo, leej twg tuaj yeem siv,
• tsis txhob tshem cov ntawv lo xim los ntawm kev txhaj tshuaj ntawm lub pob hlaws, nws tuaj yeem siv tau rau thaum muaj xwm ceev, qhia tus kws kho mob tsheb thauj neeg uas qhov tshuaj yog qhov txhaum ntawm koj cov hypoglycemic precoma lossis coma,
• cov kev coj ua ib txwm ua ntej txhua qhov kev txhaj tshuaj yuav tsum tau saib xyuas lub txee lub neej ntawm cov tshuaj thiab kuaj xyuas qhov kev npaj txhij ntawm cov koob txhaj tshuaj rau siv (tso cov kua dej me me rau hauv cov kwj nyias), thiab tom qab cov txheej txheem ua tiav, saib xyuas cov tshuaj tag nrho,
• txoj kev nruj ntawm cov hlab ntaws tso tawm khawm khawm cuam tshuam los ntawm lub cheeb ntawm rab koob thiab kev ua txhaum ntawm nws txoj kev tsis haum, kev nrawm nrawm thiab nrawm nias, plua plav lossis lwm yam khoom siv me me nkag mus hauv lub cuab yeej,
• ua kom cov xaum thiab cov koob txhaj cais tshwj xeeb, muab cia nrog rab koob txuas nrog yuav ua rau huab cua nkag mus rau hauv cov tshuaj, uas yuav ua rau muaj qhov txo qis hauv kev siv tshuaj,
• thaum lub caij huab cua sov, thaum siv cwj mem kua pleev xim sab nraum lub tsev, siv cov vov tshwj xeeb los npog nws,
• Tau txais lus ntuas los ntawm koj tus kws kho mob endocrinologist txog qhov twg thiab yuav ua li cas pov tseg cov koob, koob txhaj tshuaj, thiab ntawv pov tseg.

Thiab hauv kev xaus, peb hais kom saib cov lus qhia ua yeeb yaj kiab los ntawm tus kws kho mob endocrinologist txog cov cai thiab cov tswv yim rau kev npaj cov tshuaj insulin, nyob ntawm seb muaj hom ntaus nrig nrog cov tshuaj hormonal no li cas.

Dosage daim ntawv

Ncua rau lub subcutaneous thawj coj.

1 ml muaj:
cov tshuaj nquag: insulin lispro 100 IU,
tus zam: metacresol 2.2 mg. phenol kua 1.0 mg, glycerol (glycerin) 16 mg, protamine sulfate 0.19 mg, sodium hydrogen phosphate heptahydrate 3.78 mg, zinc oxide qs kom tau txais zinc ions 30.5 μg, dej rau kev txhaj tshuaj txog li 1 ml, 10% daws ntawm hydrochloric acid thiab / lossis 10% sodium hydroxide tov rau ib pH ntawm 7.0-7.8.

Qhov kev tshem tawm dawb uas exfoliates, sib sau ua ib cov nag lossis daus dawb thiab ntshiab, tsis muaj xim lossis yuav luag tsis muaj xim. Cov nag lossis daus tau yooj yim resuspended nrog maj mam co.

Cov chaw muag tshuaj

Cov Tshuaj Hauv Tshuaj
Humalog Mix 50 yog ib qho kev sib xyaw ua ke uas muaj kev sib tov ntawm insulin lispro 50% (kev ua kom sai ntawm tib neeg cov tshuaj insulin) thiab kev txwv tsis pub tshuaj tiv thaiv ntawm insulin lispro 50% (kev sib piv ntawm tib neeg insulin ntawm nruab nrab ntev).

Kev ua tseem ceeb ntawm insulin lyspro yog txoj cai ntawm cov metabolism hauv qabzib.

Tsis tas li ntawd, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev. Hauv cov leeg ua ke muaj qhov nce ntxiv hauv cov ntsiab lus ntawm glycogen, fatty acids, glycerol. nce protein synthesis thiab nce kev noj ntawm cov amino acids, tab sis muaj kev txo qis glycogenolysis, gluconeogenesis. ketogenesis. lipolysis. protein catabolism thiab amino acid tso tawm.

Lyspro insulin tau pom tias yog ua kom sib npaug rau tib neeg cov tshuaj insulin, tab sis nws cov nyhuv sai dua thiab siv sijhawm tsawg dua.

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), qhov koob tshuaj (ntim ntawm cov tshuaj insulin), cov ntshav txaus, lub cev kub thiab kev tawm dag zog.

Tom qab subcutaneous txhaj tshuaj ntawm Humalog® Sib tov 50, qhov pib sai ntawm kev nqis tes ua thiab qhov pib thaum ntxov ntawm kev ua haujlwm siab tshaj plaws ntawm insulin lispro tau pom. Qhov pib ntawm kev ua ntawm cov tshuaj yog tom qab kwv yees li 15 feeb, uas tso cai rau cov tshuaj kom sai ua ntej noj mov (0-15 feeb ua ntej noj mov), piv nrog tib neeg cov tshuaj insulin. Tom qab subcutaneous txhaj tshuaj ntawm Humalog® Sib tov 50, qhov pib sai ntawm kev nqis tes ua thiab qhov pib thaum ntxov ntawm kev ua haujlwm siab tshaj plaws ntawm insulin lispro tau pom. Kev txiav txim siab profile ntawm insulin lyspro protamine zoo ib yam li cov yeeb yam kev sib raug zoo ntawm cov tshuaj insulin-isophan nrog lub sijhawm ntev li 15 teev.

Cov Tshuaj Pharmacokinetics
Cov chaw muag tshuaj ntawm insulin lispro yog tus cwj pwm los ntawm kev nqus sai thiab ncav cuag lub siab nyob rau hauv cov ntshav 30-70 feeb tom qab txhaj tshuaj subcutaneous. Cov chaw muag tshuaj ntawm kev ncua ntawm insulin lysproprotamine zoo ib yam li cov tshuaj nruab nrab-insulin (insulin-isophan). Cov tshuaj pharmacokinetics ntawm cov tshuaj Humalog Mix 50 yog txiav txim siab los ntawm tus kheej pharmacokinetic cov yam ntxwv ntawm ob qho sib xyaw ntawm cov tshuaj.

Nrog kev tswj hwm ntawm lyspro insulin, kev nqus yog sai dua soluble tib neeg insulin hauv cov neeg mob uas lub raum tsis ua haujlwm. Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, pharmacokinetic sib txawv ntawm lyspro insulin thiab soluble tib neeg insulin raug pom nyob rau hauv kev ua haujlwm ntau ntawm lub raum, tsis hais txog lub raum. Nrog rau kev tswj hwm ntawm insulin lyspro, kev nqus sai thiab tshem tawm sai dua yog pom piv nrog soluble tib neeg insulin hauv cov neeg mob siab tsis ua haujlwm.

Nrog saib xyuas:

Lub caij muaj menyuam thiab kev pub niam mis,
Nrog rau lub raum tsis ua haujlwm, mob siab rau lub siab, kev ntxhov siab, kev ua si lub cev, kev hloov pauv ntawm kev noj zaub mov li niaj zaus, kev xav tau rau insulin tuaj yeem hloov pauv thiab kev txhaj tshuaj insulin yuav tsum ua.
Nrog rau lub caij nyoog ntev ntawm mob ntshav qab zib mellitus, mob ntshav qab zib neuropathy lossis siv cov beta-adrenergic thaiv cov kab mob, cov tsos mob uas kwv yees hypoglycemia tuaj yeem hloov lossis tsawg dua cov lus.

Siv thaum cev xeeb tub thiab pub niam mis

Cov kev tshawb fawb tsiaj tsis qhia txog kev muaj lub cev tsis taus lossis qhov tsis zoo ntawm cov tshuaj insulin lyspro ntawm tus me nyuam hauv plab. Tsis tau muaj kev tswjhwm sim los ntawm kev siv lyspro insulin hauv cov pojniam xeebtub. Txij li thaum kev tshawb fawb txog cov nyhuv ntawm cov tshuaj rau tsiaj kev yug me nyuam tsis tas tso cai rau cov kev ua txhaum ntxiv rau tib neeg lub cev, Humalog, Mix 50 tshuaj thaum cev xeeb tub yuav tsum tau siv yog tias muaj kev kho mob tseeb.

Cov neeg mob ntshav qab zib, nws pom zoo kom qhia rau tus kws kho mob txog qhov pib lossis npaj xeeb menyuam.

Thaum cev xeeb tub, nws yog qhov tseem ceeb tshwj xeeb los kuaj xyuas cov neeg mob uas tau txais kev kho mob insulin. Qhov kev xav tau rau insulin feem ntau poob qis thaum thawj peb lub hlis thiab nce ntxiv thaum lub sijhawm thib ob thiab thib peb. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov neeg mob uas mob ntshav qab zib mellitus thaum pub mis niam tej zaum yuav tau kho lub koob tshuaj insulin, zaub mov noj, lossis ob qho tib si.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Humalog Mix 50 yog txiav txim los ntawm tus kws kho mob ib tus zuj zus, nyob ntawm qhov kev nyeem ntawm cov ntshav ntshav.

Qhov tseeb ntawm kev muab tshuaj insulin yog tus kheej.

Cov tshuaj yuav tsum tau tswj hwm tsuas yog subcutaneously. Kev tswj hwm ntawm cov tshuaj Humalog® Mix 50 yog qhov tsis lees txais.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov.

Txhaj tshuaj subcutaneous yuav tsum tau muab rau lub xub pwg, ncej puab, pob tw lossis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj li ib hlis ib zaug. Nrog kev tswj hwm subcutaneous ntawm Humalog® Mix 50 npaj, kev saib xyuas yuav tsum tau saib xyuas kom tsis txhob siv cov tshuaj rau hauv cov lumen ntawm cov hlab ntshav. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.

Txog cov lus pom zoo rau kev txhim kho lub taub ntim hauv lub cuab yeej rau kev tswj hwm qhov Humalog® sib tov 50 npaj thiab txuas lub koob rau nws ua ntej siv cov tshuaj, nyeem cov khw muag cov lus qhia rau lub cuab yeej rau kev siv tshuaj insulin. Ua raws nraim li cov lus qhia koj nyeem.

Tom qab subcutaneous tswj hwm ntawm Humalog® Mix 50 npaj, kev pib sai ntawm kev nqis tes ua thiab qhov siab tshaj plaws thaum ntxov hauv lyspro insulin kev ua ub no raug soj ntsuam. Ua tsaug rau qhov no, Humalog® Mix 50 tuaj yeem muab tshuaj tam sim ua ntej lossis tom qab noj mov. Lub sijhawm ua haujlwm ntawm kev ncua ntawm insulin lysproprotamine. uas yog ib feem ntawm Humalog Mix 50. Nws zoo ib yam li lub sijhawm ua ntawm insulin-isophan.

Cov ntaub ntawv ntawm insulin qhov kev txiav txim siab, tsis hais txog nws hom, yuav txawv txav ob qho tib si hauv cov neeg mob sib txawv raws li lawv tus yam ntxwv, thiab hauv ib tus neeg mob nyob ntawm lub sijhawm tshwj xeeb. Ib yam li lwm yam kev npaj tshuaj insulin, lub sijhawm ua haujlwm ntawm Humalog® Mix 50 nyob ntawm qhov koob tshuaj, qhov chaw txhaj tshuaj, ntshav ntshav, kub cev thiab kev tawm dag zog.

Npaj rau qhov kev taw qhia
Ua ntej yuav siv, Humalog® Sib tov 50 daim cartridge yuav tsum tau muab nruab nrab ntawm xib teg kaum npaug thiab tshee, tig mus rau 180 ° kuj kaum zaus kom rov kho cov kua dej kom txog thaum nws dhau los ua kua dej tsis sib haum. Tsis txhob co ua kom muaj zog, vim tias qhov no tuaj yeem ua rau pom kev ua npuas, uas tuaj yeem cuam tshuam nrog koob tshuaj kom raug. Txhawm rau kom yooj yim rau kev sib xyaw, ib lub pob me me nyob sab hauv lub taub hau.

Tsis txhob siv Humalog® Mix 50. yog tias nws muaj plaub ya ri tom qab tov.

Kev tswj hwm txoj cai

1. Ntxuav koj txhais tes.
2. Xaiv qhov chaw txhaj tshuaj.
3. Npaj daim tawv nqaij ntawm qhov chaw txhaj tshuaj raws li kws kho mob pom zoo.
4. Tshem tawm ntawm lub hau sab nraud los ntawm rab koob.
5. Kho cov tawv nqaij, khaws nws rau hauv daim ntau quav.
6. Tso lub koob txhaj tshuaj subcutaneously rau hauv cov quav ntim thiab ua kev txhaj tshuaj raws li cov lus qhia siv kev siv tus xaum xim.
7. Tshem tawm rab koob thiab maj mam nyem qhov chaw txhaj tshuaj nrog paj rwb pas nrig rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.
8. Siv lub hau tiv thaiv sab nraud ntawm lub koob, rho tawm rab koob thiab pov tseg.
9. Muab lub hau ntim rau ntawm tus cwj mem.

Txog rau Kev Tshaj Tawm ® Sib tov 50 npaj hauv QuickPen TM syringe mem.
Ua ntej muab cov tshuaj insulin, nws yog qhov tsim nyog yuav tau paub koj tus kheej kom nrawm nrog QuickPen TM koob txhaj tshuaj.

Sab sij huam

Kev ntshav siab yog cov kev mob tshwm sim uas feem ntau tshwm sim nrog kev qhia ntawm txhua qhov kev npaj tshuaj insulin, suav nrog Humalog Mix 50. Kev mob ntshav qab zib siab hnyav tuaj yeem ua rau tsis nco qab thiab. hauv qhov tshwj xeeb, kom tuag.

Kev tsis haum tshuaj: cov neeg mob yuav tuaj yeem ua xua nyob rau hauv thaj chaw xws li daim tawv liab, o, lossis khaus ntawm qhov chaw txhaj tshuaj. Cov kev tshwm sim me me feem ntau ploj li ntawm ob peb hnub lossis tsheej lim tiam. Qee qhov xwm txheej, cov kev coj tus cwj pwm no tuaj yeem yog vim li cas tsis muaj feem xyuam rau cov tshuaj insulin, piv txwv li, tawv nqaij nrog lub ntsej muag ntxuav los yog siv tshuaj tsis raws cai.

Kev tsis haum rau lub cevtshwm sim los ntawm cov tshuaj insulin tshwm sim tsawg dua, tab sis muaj qhov hnyav dua. Lawv tuaj yeem pom los ntawm qhov khaus khaus tawm tsam, ua pa siav, ua tsis taus pa, txo ntshav siab, tachycardia, tawm hws. Cov uas muaj mob hnyav raug neeg lub cev tuaj yeem tas sim neej. Muaj qee zaus muaj kev fab loj heev rau qhov Humalog to Mix 50, yuav tsum tau mus kho tamsid. Tej zaum koj yuav xav tau pauv hloov insulin, lossis desensitization.

Nrog lub caij nyoog siv - kev txhim kho yog ua tau lipodystrophy ntawm qhov chaw txhaj tshuaj.

Cov lus tshwm sim:
Cov kab mob ntawm kev txhim kho ntawm edema tau qhia, feem ntau, nrog kev ceev nrawm ntawm cov concentration ntawm cov piam thaj hauv cov ntshav tawm tsam keeb kwm ntawm kev siv tshuaj insulin ntau dua nrog kev pib tsis txaus siab glycemic tswj.

Noj ntau dhau

Kev noj tshuaj ntau dhau ntawm cov tshuaj insulin ua rau ua rau lub ntsejmuag ntshav siab, nrog rau cov tsos mob hauv qab no: qaug zog, tawm hws, tachycardia, pallor ntawm daim tawv nqaij, mob taub hau, tshee tshee, ntuav, tsis meej pem. Hauv qee qhov xwm txheej, piv txwv li, nrog lub sijhawm ntev los ntawm tus kabmob lossis nrog kev soj ntsuam mob ntshav qab zib mellitus, cov tsos mob ntawm cov ua ntej ntawm kev mob ntshav qab zib tuaj yeem hloov pauv.

Cov ntshav qab zib me me feem ntau tuaj yeem nres los ntawm kev noj cov piam thaj lossis qab zib. Yuav tsum tau txhaj koob tshuaj insulin, noj zaub mov, lossis ua kom lub cev qoj ib ce. Kev kho cov ntshav qog qis kawg tuaj yeem nqa tawm los ntawm kev siv tshuaj intramuscular lossis subcutaneous ntawm glucagon. ua raws li kev noj haus ntawm carbohydrates. Cov teeb meem mob ntshav qab zib tsawg, nrog kev tsis nco qab, ua kom mob hlwb los yog mob hlwb, raug tso tseg los ntawm cov tshuaj intramuscular / subcutaneous ntawm glucagon los yog kev tswj hwm ntshav ntawm cov tshuaj uas muaj cov tshuaj dextrose (qabzib). Tom qab nws rov qab nco qab, tus neeg mob yuav tsum tau muab cov khoom noj uas yog carbohydrate kom tiv thaiv kev rov qab txhim kho kev mob ntshav qab zib. Kev noj ntxiv ntawm cov carbohydrates thiab kev saib xyuas tom qab ntawm tus neeg mob tej zaum yuav tsum tau, txij li ib qho kev rov qab ua ntawm hypoglycemia yog ua tau.

Kev cuam tshuam nrog lwm yam tshuaj

Cov nyhuv hypoglycemic ntawm Humalog® Mix 50 tshuaj tau txo qis thaum siv ua ke nrog cov tshuaj hauv qab no: tshuaj tiv thaiv qhov ncauj, glucocorticosteroids, iodine-muaj cov thyroid hormones, danazol. beta₂adrenergic agonists (xws li, ritodrin, salbutamol, terbutaline), thiazide diuretics, chlorprothixene, diazoxide. isoniazid, nicotinic acid, phenothiazine derivatives.

Cov nyhuv rau hypoglycemic ntawm Humalog® Mix 50 yog txhim kho los ntawm: beta-blockers, ethanol thiab ethanol-muaj cov tshuaj, anabolic steroids, fenfluramine, guanethidine, tetracyclines, qhov ncauj tshuaj hypoglycemic. salicylates (e.g. acetylsalicylic acid), tshuaj tua kab mob sulfonamide, qee cov tshuaj tiv thaiv kab mob (monoamine oxidase inhibitors), angiotensin hloov mus rau enzyme inhibitors (captopril, enapril), octreotide, angiotensin II receptor antagonists.

Beta blockers. clonidine, reserpine yuav npog qhov kev ua kom pom cov tsos mob ntawm qog ntshav qab zib.

Qhov sib cuam tshuam ntawm qhov Humalog® Mix 50 nrog rau lwm cov tshuaj insulin tsis tau kawm.

Yog tias koj yuav tsum siv lwm cov tshuaj, ntxiv rau insulin, sab laj koj tus kws kho mob.

Kev siv tib lub sijhawm ntawm Humalog® Mix 50 nrog thiazolidinedione tshuaj muaj peev xwm nce kev pheej hmoo ntawm edema thiab lub plawv tsis ua haujlwm, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kab mob ntawm cov hlab plawv.

Cov lus qhia tshwj xeeb

Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis kev npaj tshuaj insulin nrog cov lag luam sib txawv yuav tsum tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj. Hloov pauv hauv kev ua, hom (cov chaw tsim khoom), hom (soluble insulin, insulin-isophan, thiab lwm yam). hom tsiaj (tsiaj, tib neeg, analogue ntawm tib neeg insulin) thiab / lossis hom kev tsim tawm (DNA tso tshuaj insulin lossis insulin ntawm cov tsiaj keeb kwm) yuav xav tau kho kom haum cov koob tshuaj.

Hauv qee tus neeg mob, yuav tau kho kom tau cov koob tshuaj thaum hloov los ntawm tsiaj los ntawm insulin los rau tib neeg insulin. Qhov no tuaj yeem tshwm sim twb tau dhau los ntawm thawj zaug kev tswj hwm ntawm tib neeg li kev npaj tshuaj insulin lossis maj mam li ntawm ob peb lub lis piam lossis hli tom qab hloov mus.

Kev tswj tsis tau tus mob hypoglycemic lossis hyperglycemic uas tuaj yeem ua rau tsis nco qab, tsis nco qab, lossis tuag. Cov tsos mob ua ntej ntawm lub ntsej muag hypoglycemia tuaj yeem hloov lossis tsis tau hais tawm nrog cov ntshav qab zib mellitus ntev, mob ntshav qab zib neuropathy, lossis kho nrog tshuaj xws li beta-blockers.

Kev noj tshuaj tsis txaus lossis tsis ncua kev kho mob, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib hom 1 mob ntshav qab zib, tuaj yeem ua rau mob hyperglycemia thiab ntshav qab zib ketoacidosis (mob uas yuav ua rau tuag taus rau tus neeg mob).

Qhov xav tau rau cov insulin tuaj yeem txo nrog lub raum tsis ua haujlwm, nrog rau lub siab tsis ua haujlwm vim qhov txo qis gluconeogenesis muaj peev xwm thiab txo qis ntawm cov tshuaj insulin metabolism, txawm li cas los xij, hauv cov neeg mob mob siab tsis ua haujlwm, insulin tsis kam tuaj yeem ua rau muaj kev xav tau ntxiv.

Txoj kev xav tau cov tshuaj insulin tuaj yeem nce ntxiv nrog qee yam kab mob lossis nrog kev xav hauv siab.

Kev hloov kho ntawm cov koob tshuaj insulin tej zaum yuav tsum tau nrog kev nce ntxiv hauv kev ua haujlwm lossis nrog kev hloov pauv ntawm ib txwm noj zaub mov. Kev tawm dag zog tuaj yeem ua rau muaj kev pheej hmoo ntawm cov ntshav qab zib tsawg dua.

Thaum siv cov tshuaj insulin nyob rau hauv kev sib xyaw nrog cov tshuaj ntawm thiazolidinedione pab pawg, qhov kev pheej hmoo ntawm kev txhim kho edema thiab mob plawv sai dua, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kab mob ntawm cov hlab plawv thiab muaj cov kev pheej hmoo ua rau mob plawv tsis ua haujlwm.

Txhawm rau zam kom kis tau tus kab mob sib kis tau, txhua daim cartridge / koob txhaj tshuaj yuav tsum siv los ntawm tsuas yog ib tus neeg mob, txawm tias yuav raug hloov rab koob. Daim Cartridges nrog Humalog® Mix 50 yuav tsum tau siv nrog cov phwj syringe uas yog CE cim. raws li cov lus qhia ntawm lub chaw tsim tshuaj paus lub tshuab.

Muaj feem xyuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem

Thaum lub caij tus mob ntshav qab zib tsis txaus, qhov kev mloog zoo thiab ceev ntawm lub hlwb kev xav yuav txo qis. Qhov no tuaj yeem txaus ntshai nyob rau hauv qhov xwm txheej uas qhov peev xwm tshwj xeeb tshaj yog tsim nyog (piv txwv, tsav tsheb lossis tshuab siv tshuab).

Cov neeg mob yuav tsum tau qhia rau kom ceev faj kom tsis txhob mob ntshav qab zib thaum tsav tsheb thiab tshuab. Qhov no yog qhov tshwj xeeb tshaj yog rau cov neeg mob uas cov tsos mob me lossis tsis tuaj, ua ntej ntawm cov ntshav ntog ntshav qab zib lossis nrog rau kev txhim kho ntshav nce siab ntau ntau. Hauv cov xwm txheej zoo li no, tus kws kho mob yuav tsum soj ntsuam qhov ua tau ntawm kev tsav tsheb tus neeg mob nrog tsheb thiab cov txheej txheem.

Daim ntawv tso tawm

Ncua rau lub subcutaneous tswj ntawm 100 IU / ml.

Cartridges:
3 ml ntawm cov tshuaj rau ib lub cartridge. Tsib cartridges ib lub hlwv. Ib qho blister ua ke nrog cov lus qhia rau kev siv rau hauv thawv ntawv thawv.

Koob txhaj tshuaj QuickPM TM:
3 ml ntawm cov tshuaj hauv daim cartridge, ua rau hauv Cov Cwj mem ceev ceev TM syringe cwj mem. Tsib QuickPen TM syringe cwjmem, txhua tus nrog cov lus qhia rau kev siv thiab QuickPEN TM syringe cwj mem, rau siv nyob rau hauv pob ntawv ntawm cardboard.

Lub npe thiab chaw nyob ntawm cov chaw tsim khoom

Chaw tsim tshuaj paus thiab pob:
Lilly Fabkis, Fab Kis
2 Ru du Colonel Lilly. 67640 Fegersheim, Fab Kis

Packer thiab muab cov kev tswj zoo:
Lilly Fabkis, Fab Kis
2 Ru du Colonel Lilly. 67640 Fegersheim
lossis
Eli Lilly thiab Tuam Txhab, Tebchaws Asmeskas (Kev Sau Se Ceev Pen TM)
Khab. Indiana 46285

Kev tshuaj xyuas ntawm cov kws kho mob txog qhov humalogue sib tov 50

Txo cov naj npawb ntawm cov hno ntawm 5-6 mus rau 3 (insulin yog siv peb zaug ib hnub ua ntej noj mov loj). Ib qho xaum xaum xaum ib qho ntawm ob qho - tsis muaj kev ntxhov siab rau cov neeg laus thiab tsis zoo pom cov neeg mob. Ua haujlwm zoo nrog hom 2 mob ntshav qab zib thaum kho tom qab kho tas xav tau ntau dua li qhov tsis txaus. Rau cov neeg mob uas muaj ntshav qab zib tsawg ntawm cov zaub mov (vim hais tias insulin basal tsawg dua lwm yam kev sib xyaw ua ke).

Thawj qhov sib xyaw ntawm 50 txog 50 - ib nrab ntawm basal, ib nrab ultrashort. Lub tswv yim zoo rau cov neeg mob ntshav qab zib hom 2 uas yav tas los tau txais kev kho mob insulin hauv ib qho chaw pib bolus regimen. Tam sim no, kuv cov neeg mob uas muaj keeb kwm mob ntshav qab zib ntev, muaj mob encephalopathy, yuav tsis yuam kev ntev rau cov "insulin" nrog "luv"!

Tus naj npawb ntawm kev txhaj tshuaj 2 zaug hauv ib hnub es tsis txhob 4-5.

Ib qho kev lav ris zoo rau txoj kev noj haus thiab kev noj haus yog qhov xav tau.

Siv kev sib xyaw ua ke ntawm cov tshuaj insulins yuav tsum muaj txoj hauv kev ua tib zoo los suav cov ntawv qhia zaub mov thiab khoom noj, ib qho txuj ci zoo hauv kev suav thiab ntsuas qhov ua tau zoo ntawm macronutrients. Koj tuaj yeem saib qhov no yog qhov ua tau zoo, vim tias tus neeg mob tus kheej lub siab qhuab qhia nce ntxiv, kev ua zaub mov tsis raug tshem tawm.

Thov nyeem cov lus qhia ua ntej siv.

Taw qhia
Cwj mem ceev ceev cwj mem tau yooj yim siv. Nws yog cov cuab yeej siv los tswj cov tshuaj insulin (ib qho “insulin syringe cwj mem”) muaj 3 ml (300 units) ntawm kev npaj tshuaj insulin nrog ib qho dej ntawm 100 IU / ml. Koj tuaj yeem hno ntawm 1 txog 60 units ntawm insulin rau ib zaug txhaj. Koj tuaj yeem tsim koob tshuaj nrog qhov tseeb ntawm ib chav. Yog tias koj tau teeb tsa ntau cov koog. Koj tuaj yeem kho qhov koob tshuaj yam tsis poob los ntawm insulin.

Ua ntej siv QuickPen cwj mem kua muag, nyeem phau ntawv no kiag thiab ua raws nws cov lus qhia kom raug. Yog tias koj tsis ua raws li tag nrho cov lus qhia no, koj yuav tau txais cov tshuaj insulin tsawg dhau los yog siab dhau.

Koj QuickPen insulin cwj mem yuav tsum siv koj txoj kev txhaj tshuaj nkaus xwb. Tsis txhob kis tus cwj mem los yog rab koob rau lwm tus, vim qhov no yuav ua rau kis tus kab mob. Siv ib rab koob tshiab rau txhua txoj kev txhaj tshuaj.

TSIS TXHOB SIV cov xaum xaum hluav taws xob yog ib qho ntawm nws qhov chaw raug puas tsuaj lossis tawg. Yuav tsum tau xaum ib qho xaum xoob xoob uas siv thaum siv xaum xaum los yog nws puas ntsoog.

Nws tsis raug nquahu kom siv cov kua xaum xaum rau cov neeg mob uas tsis pom kev lossis tsis pom kev zoo yam tsis muaj kev pab cuam ntawm cov neeg pom kom tau kawm los siv cov kua xaum xaum.

Cwj mem ceev ceev Kev npaj

Cov ntawv tseem ceeb

• Nyeem thiab ua raws cov lus qhia rau kev siv piav qhia hauv cov lus qhia rau kev siv tshuaj.
• Tshawb xyuas daim ntawv lo ntawm daim duab xaum xim ua ntej txhua qhov kev txhaj tshuaj kom paub tseeb tias cov khoom tsis tau tas sij hawm thiab koj siv hom tshuaj insulin kom raug: tsis txhob tshem daim ntawv lo los ntawm kua cwj mem.

Nco tseg: Cov xim ntawm khawm sai ntawm QuickPen syringe cwj mem sib raug rau cov xim ntawm cov nqaij ntuag rau ntawm daim ntawv lo tus cwj mem thiab nyob ntawm hom tshuaj insulin. Hauv phau ntawv no, khawm koob tshuaj yog grayed tawm. Cov xim xiav ntawm QuickPen syringe mem lub cev qhia tau tias. tias nws yog npaj rau siv nrog Humalog® cov khoom lag luam.

Cov lus qhia luv luv

Humalog sib tov 50 - qhov sib xyaw ntawm luv luv ua yeeb yam insulin nrog nruab nrab-insulin. Lowers ntshav qab zib. Nws nthuav tawm cov nyhuv anabolic, inhibits catabolism hauv ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg. Nws muaj cov tshuaj lom ib ce nrog tib neeg cov tshuaj insulin, tab sis pib ua kom sai dua. Tom qab tswj hwm tus neeg mob, nws pib ua raws li thaj tsam tom qab 15 feeb, uas tso cai rau koj ua qhov kev txhaj tshuaj tam sim ntawd ua ntej noj mov. Peak insulin theem hauv cov ntshav tau sau tseg 30-70 feeb tom qab kev tswj hwm. Cov lus pom zoo rau kev siv lub cuab yeej rau kev tswj hwm tshuaj yog tsim muaj hauv pob ntawv pob. Ua ntej ua cov txheej txheem, nws yog ib qho tsim nyog yuav tsum muab cov tshuaj insulin daws qhov tsis sib thooj, rau cov thawv ntawd nrog cov tshuaj tau dov ob peb zaug ntawm xib teg thiab tig mus. Lub zog khov kho tsis pom zoo vim tias Hauv qhov no, ua npuas ncauj yuav cuam tshuam nrog kev noj kom yog. Txhawm rau pab txhawb lub cev kom rov ua dua, lub khob me me tso rau hauv lub taub hau. Lub xub ntiag ntawm flakes tom qab sib tov yog lub hauv paus rau kev tsis kam siv cov tshuaj. Ntxuav tes kom huv ua ntej kev txhaj tshuaj. Kev txhaj tshuaj yog ua rau hauv daim tawv nqaij tsau nrog tus ntiv tes ntawm txhais tes dawb. Tom qab tshem tawm rab koob, qhov chaw txhaj tshuaj yog maj mam nias rau ob peb feeb nrog rab pas rwb mus so. Tom qab qhov txhaj tshuaj, rab koob tau rov ua dua, thiab daim ntawv txhaj tshuaj yog kaw nrog lub hau tiv thaiv. Ua ntej tswj hwm, txoj kev daws teeb meem yuav tsum tau nqa mus rau chav tsev kub. Kev txhaj tshuaj subcutaneous yog ua nyob rau hauv deltoid leeg, plaub leeg, sab nraub qaum phab ntsa, gluteus maximus. Kev saib xyuas yuav tsum tau saib xyuas kom tsis txhob qhia qhov kev daws teeb meem rau hauv cov hlab ntshav. Pom zoo kos duab txhaj tsis pom zoo. Ntawm qhov tsis xav tau txoj kev xav tshwm sim cuam tshuam nrog kev siv Humalog sib xyaw 50, nrog rau lwm yam tshuaj insulin npaj, hypoglycemia feem ntau yuav muaj. Hauv cov xwm txheej hnyav tshwj xeeb, qhov tsis nco qab nrog lub txiaj ntsig tuag yuav tsis raug tshem tawm.

Qee zaum cov neeg mob tuaj yeem tsim kev tawm tsam hauv cheeb tsam, tshwm sim los ntawm hyperemia, o, khaus ntawm qhov chaw txhaj tshuaj. Cov kev rov tshwm sim li no tsis muaj qhov teeb meem tseem ceeb hauv kev kho mob thiab feem ntau kis xwm yeem dhau qhov tsis muaj kev kho mob. Muaj tsawg dua (tab sis hnyav dua, suav nrog lub neej muaj sia) yog cov kev ua xua uas ua rau thoob plaws lub cev: tag nrho khaus, ua tsis taus pa thiab ua pa nrawm, hypotension, plawv dhia, hyperhidrosis. Hauv cov xwm txheej zoo li no, yuav tsum tau kho kho tam sim ntawd. Nrog kev siv lub sijhawm ntev nrog kev tswj hwm nquag ntawm tib qhov chaw ua ke, lipodystrophy hauv zos yuav tsim kho. Qhov ua tau zoo ntawm cov tshuaj txo qis thaum nws siv ua ke nrog ntsiav tshuaj tiv thaiv kab mob, glucocorticosteroid hormones, iodine-muaj cov thyroid hormones, beta-2 adrenoreceptor stimulants, thiazide diuretics, antipsychotic chlorprotixene, potassium channel activator diazoxide, isotonic tuberculosis tshuaj. Beta-adrenoreceptor blockers, ethanol-muaj cov khoom, anabolic steroids, qab los noj mov regulator fenfluramine, sympatholytic guanethidine, tetracycline thiab sulfonamide tshuaj tua kab mob, ntsiav tshuaj hypoglycemic tshuaj, salicylic acid inhibitors, inhibitors inhibit hypoglycemic effect ntawm cov tshuaj. Beta-adrenergic blockers, clonidine, reserpine tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib. Kev siv lwm cov tshuaj hauv kev sib xyaw nrog Humalog Mix 50 tsuas yog ua tau los ntawm kev pom zoo nrog tus kws kho mob. Kev siv cov tshuaj ua ke nrog glitazones (rosiglitazone, pioglitazone) tuaj yeem pab txhawb kev txhim kho ntawm edema thiab decompensated tsis ua haujlwm ntawm lub plawv cov leeg.

Kws Tshuaj

Humalog Mix 50 yog ib qho kev sib xyaw ua ke uas muaj kev sib tov ntawm insulin lispro 50% (kev ua kom sai ntawm tib neeg cov tshuaj insulin) thiab kev txwv tsis pub tshuaj tiv thaiv ntawm insulin lispro 50% (kev sib piv ntawm tib neeg insulin ntawm nruab nrab ntev).

Kev ua tseem ceeb ntawm insulin lyspro yog txoj cai ntawm cov metabolism hauv qabzib.

Tsis tas li ntawd, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab nce ntxiv ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Nws tau qhia tias Lyspro insulin yog equimolar rau tib neeg cov tshuaj insulin, tab sis nws cov nyhuv sai dua thiab kav ntev dua. Tom qab subcutaneous txhaj tshuaj ntawm Humalog Mix 50, qhov pib sai ntawm kev nqis tes ua thiab qhov pib thaum ntxov ntawm lub ncov kev ua haujlwm ntawm lyspro insulin raug pom. Qhov pib ntawm cov tshuaj yog kwv yees li 15 feeb tom qab, uas tso cai rau koj los tswj cov tshuaj tam sim ua ntej noj mov (0-15 feeb ua ntej noj mov), piv nrog tib neeg cov tshuaj insulin. Tom qab subcutaneous txhaj tshuaj ntawm Humalog Mix 50, qhov pib sai ntawm kev nqis tes ua thiab qhov pib thaum ntxov ntawm lub ncov kev ua haujlwm ntawm lyspro insulin raug pom. Kev txiav txim siab profile ntawm insulin lyspro protamine zoo ib yam li cov profile ntawm kev ua ntawm cov tshuaj insulin-isophan nrog lub sijhawm ntev li 15 teev.

Cov Tshuaj Pharmacokinetics

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), qhov koob tshuaj (ntim ntawm cov tshuaj insulin), cov tshuaj insulin nyob rau hauv cov tshuaj, thiab lwm yam Nws muab faib tsis ncaj ntawm cov ntaub so ntswg, thiab tsis nkag rau hauv qhov chaw tiv thaiv thiab nkag mus rau niam mis. Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum (30-80%).

Sab sij huam

Kev mob ntshav qab zib yog qhov tshwm sim feem ntau tshwm sim nrog kev tswj hwm ntawm txhua qhov kev npaj tshuaj insulin, suav nrog Humalog Mix 50. Kev mob ntshav qis tuaj yeem ua rau tsis nco qab thiab, tshwj tsis yog kev tuag.

Ua xua: cov neeg mob yuav muaj kev tsis haum hauv zos xws li ua pob liab liab, o, lossis khaus ntawm qhov chaw txhaj tshuaj. Cov kev tshwm sim me me feem ntau ploj li ntawm ob peb hnub lossis tsheej lim tiam. Qee qhov xwm txheej, cov kev coj tus cwj pwm no tuaj yeem yog vim li cas tsis muaj feem xyuam rau cov tshuaj insulin, piv txwv li, tawv nqaij nrog lub ntsej muag ntxuav los yog siv tshuaj tsis raws cai.

Kev tsis haum rau lub cev vim mob los ntawm cov tshuaj insulin tshwm sim tsawg dua, tab sis yuav mob hnyav dua. Lawv tuaj yeem pom tshwm sim los ntawm kev tawm tsam dav dav, ua tsis taus pa, txog siav, txo ntshav siab, ntshav nce siab, thiab tawm hws. Cov uas muaj mob hnyav raug neeg lub cev tuaj yeem tas sim neej. Muaj qee zaus muaj kev fab loj heev rau Humalog Mix 50, yuav tsum tau kho tamsid. Tej zaum koj yuav xav tau pauv hloov insulin, lossis desensitization.

Nrog lub sijhawm siv ntev - kev tsim kho ntawm lipodystrophy ntawm qhov chaw txhaj tshuaj yog ua tau.

Cev xeeb tub thiab lactation

Qhov kev tshawb fawb txaus thiab tswj tau zoo hauv cov poj niam cev xeeb tub tsis tau ua. Cov neeg mob uas mob ntshav qab zib mellitus tau qhia rau tus kws kho mob txog kev muaj cev xeeb tub lossis npaj yuav xeeb tub. Thaum cev xeeb tub, nws yog qhov tseem ceeb tshwj xeeb los kuaj xyuas cov neeg mob uas tau txais kev kho mob insulin. Qhov xav tau rau insulin feem ntau poob qis thaum lub sijhawm 1 hlis thiab nce ntxiv thaum lub sijhawm II thiab III txiav. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov neeg mob uas mob ntshav qab zib mellitus thaum pub mis niam tej zaum yuav tau kho lub koob tshuaj insulin, zaub mov noj, lossis ob qho tib si.

Xim Coding ntawm Koob Yees Duab:

• Koj tus kws kho mob tau sau hom tshuaj insulin uas haum rau koj tshaj plaws. Ib qho kev pauv twg hauv kev kho tshuaj insulin yuav tsum tau ua yog nyob ntawm kev saib xyuas ntawm kws kho mob nkaus xwb.
• QuickPen Syringe Cwj mem yog pom zoo siv nrog rab koob Becton. Dickinson thiab Tuam Txhab (BD) rau cov phwj pho kua roj.
• Ua ntej siv cov koob txhaj syringe, nco ntsoov tias rab koob tau txuas nrog lub xias nqus.
• Ua raws cov lus qhia tom qab no.

Cov lus nquag nug txog kev npaj QuickPen Syringe Cwj mem rau kev siv

• Kuv cov tshuaj insulin npaj yuav zoo li cas? Qee qhov insulin npaj yog turbid kev ncua, thaum lwm tus yog cov kev daws teeb meem meej, nco ntsoov nyeem cov lus piav qhia ntawm insulin hauv daim ntawv Cov lus qhia rau kev siv.
• Kuv yuav ua li cas yog tias kuv cov tshuaj noj kom siab dua 60 units? Yog tias qhov tshuaj muab rau koj yog tshaj 60 units. Koj yuav tsum tau txhaj koob thib ob, lossis koj tuaj yeem tiv tauj koj tus kws kho mob txog qhov no.
• Vim li cas kuv yuav tsum siv rab koob tshiab rau txhua txoj kev txhaj tshuaj? Yog tias cov koob tau rov qab siv, koj tuaj yeem tau txais cov koob tshuaj tsis yog lawm, koob yuav dhau los, lossis tus cwj mem yuav txhawm rau, lossis koj yuav raug kis vim tias muaj teeb meem ua kom menyuam yaus.
• Kuv yuav ua li cas yog tias kuv tsis paub meej tias muaj cov insulin ntau npaum li cas nyob hauv kuv lub taub ntawv? Muab cov tes rub kom lub taub ntawm rab koob taw thiaj poob. Cov nplai ntawm cov neeg lim hle hauv ntshiab qhia pom tias kwv yees li ntawm cov ntsuas ntawm insulin ntxiv. Cov zauv no TSIS TXHOB siv los teem lub koob tshuaj.
• Kuv yuav ua li cas yog tias kuv tsis tuaj yeem tshem lub hau tawm ntawm rab koob xaum hluav taws? Txhawm rau kom tshem lub hau, rub rau nws. Yog tias koj muaj teeb meem nyuaj hle lub hau, ua tib zoo tig lub hau moos thiab moos kom txhua yam rov qab. tom qab ntawd, rub tawm, tshem lub hau.

Kuaj xyuas QuickPen Syringe Cwj mem rau Insulin

Cov ntawv tseem ceeb

• Kuaj koj cov insulin kom tsawg txhua zaus. Kev kuaj xyuas cov tshuaj insulin xa tawm los ntawm rab koob txhaj tshuaj yuav tsum tau ua ua ntej txhua qhov kev txhaj tshuaj kom txog thaum lub qhov ncauj me me ntawm insulin tshwm sim kom paub tseeb tias cov kua mem yog npaj rau cov koob tshuaj.
• Yog tias koj tsis kuaj koj cov insulin kom tsawg ua ntej qhov trickle tshwm, koj yuav tau txais insulin ntau dhau los yog ntau dhau.

Cov Lus Nquag Nug Txog Kev Ntsuas Cov Insulin

• Vim li cas kuv thiaj yuav tsum kuaj xyuas kuv cov tshuaj insulin ua ntej txhua qhov txhaj tshuaj?
  1. Qhov no nco ntsoov tias tus cwj mem tau npaj txhij rau koob tshuaj.
  2. Qhov no ua pov thawj tias qhov ua kom yuam kev ntawm insulin los tawm ntawm rab koob thaum koj nias lub koob tshuaj.
  3. Qhov no tshem tawm cov cua uas tuaj yeem sib sau hauv rab koob lossis insulin daim cartridge thaum siv.
• Kuv yuav ua li cas yog tias kuv tsis tuaj yeem nias lub pob koob tshuaj thaum lub sij hawm QuickPen's insulin kuaj?
  1. Rhais ib rab koob tshiab.
  2. Txheeb tshuaj insulin los ntawm tus cwj mem.
• Kuv yuav ua li cas yog tias kuv pom cua npuas hauv lub cartridge?
• Koj yuav tsum kuaj xyuas cov tshuaj insulin los ntawm tus cwj mem.
  Nco ntsoov tias koj tsis tuaj yeem khaws cov xaum xaum xaum nrog lub koob uas txuas rau nws, vim qhov no tuaj yeem ua rau kom muaj huab cua npuas hauv lub thawv ntim tshuaj insulin. Cov pa npuas me me tsis cuam tshuam rau qhov koob tshuaj, thiab koj tuaj yeem nkag rau koj cov tshuaj raws li ib txwm muaj.

Cov kev qhia ntawm koob tshuaj uas tsim nyog

Cov ntawv tseem ceeb

• Ua raws li kev cai ntawm asepsis thiab tshuaj tua kab mob uas koj tus kws kho mob pom zoo.
• Nco ntsoov nkag mus rau qhov yuav tsum tau txhaj uas yog nias thiab tuav lub koob tshuaj thiab maj mam suav rau 5 ua ntej tshem rab koob. Yog hais tias insulin poob los ntawm rab koob, feem ntau yuav muaj. Koj tsis tau tuav rab koob hauv qab koj daim tawv ntev dhau los.
• Txo qhov ntxig ntawm qhov ntxig ntawm lub qhov ntswg yog qhov ib txwm. Qhov no yuav tsis cuam tshuam rau koj cov koob tshuaj.
• Lub taub ntim koob txhaj tshuaj yuav tsis tso cai rau koj los kos ib lub koob tshuaj ntau dua li ntawm cov lej ntawm cov tshuaj insulin nyob hauv daim ntim taub hau.
• Yog tias hauv kev poob siab tias koj tau muab tshuaj tag nrho, tsis txhob muab rau lwm lub tshuaj. Hu rau koj tus sawv cev Lilly lossis mus ntsib kws kho mob kom tau kev pab.
• Yog tias koj cov tshuaj ntau dua cov naj npawb ntawm cov seem hauv lub taub hau. Koj tuaj yeem sau cov tshuaj insulin ntxiv nyob rau hauv tus cwj mem syringe no thiab tom qab ntawd siv tus cwj mem tshiab los ua kom tiav kev tswj hwm los ntawm cov koob tshuaj uas xav tau, LOSSIS nkag rau tag nrho cov tshuaj tsim nyog siv cov koob txhaj tshiab.
• Tsis txhob sim txhaj tshuaj insulin los ntawm kev hloov lub pob tshuaj. Koj yuav TSIS TAU tshuaj insulin yog tias koj tig lub pob tshuaj. Koj yuav tsum nias lub koob txhaj tshuaj rau hauv txoj kab ncaj ncaj kom tau txais koob tshuaj ntawm cov tshuaj insulin.
• Tsis txhob sim hloov cov tshuaj ntawm cov tshuaj insulin thaum txhaj tshuaj.
• Qhov siv koob yuav tsum tau muab pov tseg kom raws li cov kev pov tseg kho mob hauv zos.
• Tshem tawm rab koob tom qab txhua hno tshuaj.

Koob Tshuaj Nug Txog

• Vim li cas nws tsis yooj yim kom nias lub koob txhaj tshuaj thaum kuv sim txhaj tshuaj?
  1. Koj rab koob yuav txhaws tau. Sim txuas cov koob tshiab. Sai li koj ua nws. Koj tuaj yeem pom tau li cas cov insulin tawm ntawm rab koob. Tom qab ntawv xyuas tus cwj mem rau cov tshuaj insulin.
  2. Kev nias ceev ntawm lub koob tshuaj khawm tuaj yeem ua rau lub pob nyem. Kev qeeb qeeb nias lub koob txhaj tshuaj tuaj yeem ua rau nias yooj yim dua.
  3. Kev siv lub taub loj dua yuav ua kom yooj yim nias lub pob koob txhaj thaum lub sijhawm txhaj. Nrog koj tus kws kho mob tham txog seb rab koob xev twg thiaj zoo rau koj.
  4. Yog tias nias lub pob thaum lub sijhawm tswj hwm kev tuav pov hwm yuav tsum nruj tom qab txhua cov ntsiab lus saum no tau ua tiav, tom qab ntawv txhaj tshuaj yuav tsum tau hloov.
• Kuv yuav ua li cas yog tias siv cwj mem ceev ceev siv thaum siv?
  Koj tus cwj mem yuav daig yog tias nws nyuaj rau kev txhaj tshuaj lossis teeb tshuaj. Txhawm rau tiv thaiv tus xaum xim los ntawm kev lo:
  1. Rhais ib rab koob tshiab. Sai li koj ua nws. Koj tuaj yeem pom tau li cas cov insulin tawm ntawm rab koob.
  2. Tshawb xyuas cov tshuaj insulin.
  3. Teem qhov tsim nyog yuav tau thiab txhaj tshuaj.
  Tsis txhob sim ntub cov koob txhaj tshuaj, vim tias qhov no yuav ua kev puas tsuaj ntawm koob txhaj tshuaj.
  Nias lub pob koob tshuaj yuav ua tau nruj yog tias muaj teeb meem txawv teb chaws (av, plua plav, zaub mov, insulin lossis lwm yam kua) nkag hauv qab tus cwj mem. Tsis txhob cia impurities nkag mus hauv cov xaum xim.
• Vim li cas cov tshuaj insulin ntws tawm ntawm rab koob tom qab kuv tau ua tiav kev noj tshuaj rau kuv?
  Tej zaum. Koj tshem lub koob sai dhau ntawm daim tawv nqaij.
  1. Nco ntsoov tias koj pom tus lej "O" nyob rau hauv lub ntsuas qhov ntsuas.
  Txhawm rau muab tshuaj rau tom ntej, nias thiab tuav lub pob koob tshuaj thiab maj mam suav rau 5 ua ntej tshem rab koob.
• Kuv yuav ua dab tsi yog tias kuv cov koob tshuaj tau teeb tsa thiab lub koob tshuaj khawm tshwm sim tuaj sab hauv tsis muaj ib rab koob uas txuas nrog lub koob txhaj tshuaj?
  1. Tig lub pob tshuaj rov qab rau xoom.
  2. Rhais ib rab koob tshiab.
  3. Ua ib qho tshuaj insulin.
  4. Teem qhov koob tshuaj thiab hno.
• Kuv yuav tsum ua li cas yog tias kuv tso cov koob tshuaj tsis yog (ntau dhau lossis siab dhau)?
  Tig lub koob tshuaj rov qab lossis xa rov qab los kho qhov tshuaj.
• Kuv yuav ua li cas yog tias kuv pom cov insulin tawm hauv lub tes tsho thaum lub caij xaiv koob lossis hloov kho?
  Tsis txhob noj ib qho tshuaj, zoo li koj yuav tsis tau txais koj cov tshuaj tag nrho. Teeb tus xaum xaum rau tus naj npawb xoom thiab rov tshawb xyuas cov tshuaj insulin los ntawm cov xaum xaum (saib ntu "Tshawb xyuas QuickPen syringe cwj mem rau Insulin Xa"). Teem qhov tsim nyog yuav tau thiab txhaj tshuaj.
• • Kuv yuav ua dab tsi yog tias tsim tsis tau tag nrho kuv cov tshuaj?
  Tus xaum xaum yuav tsis tso cai rau koj los tsim cov koob tshuaj ntau dhau ntawm cov lej ntawm cov insulin nyob hauv daim ntim taub hau. Piv txwv li, yog tias koj xav tau 31 units, thiab tsuas yog 25 units nyob hauv daim cartridge, ces koj yuav tsis tuaj yeem hla tus lej 25 thaum lub sijhawm nruab. Tsis txhob sim teeb tsa qhov koob los ntawm kev mus ntawm tus lej no. Yog tias cov koob tshuaj ib nrab tawm hauv tus cwj mem, ces koj tuaj yeem:
  1. Nkag mus rau qhov siv ib nrab ntawm no, thiab tom qab ntawd nkag mus rau qhov seem uas yog siv tus cwj mem tshiab.
  lossis
  2. Tshaj tawm cov tshuaj tag nrho los ntawm cov kua mem tshiab.
• Vim li cas kuv tsis tuaj yeem tsim koob tshuaj kom siv cov tshuaj insulin uas tsawg nyob hauv kuv lub taub hau?
  Cov koob txhaj tshuaj yog tsim los muab kev nkag mus tsawg kawg. 300 units ntawm insulin. Lub cuab yeej ntawm rab koob xaum hluav taws xob tiv thaiv lub pob txha taub los ntawm kev ua kom tiav, vim tias qhov tshuaj me me uas tseem nyob hauv daim cartridge tsis tuaj yeem raug txhaj nrog qhov tseeb uas tsim nyog.

Cia thiab pov tseg

Cov ntawv tseem ceeb

• Rab koob txhaj tshuaj tsis tuaj yeem siv yog tias nws tau nyob sab nraum lub tub yees rau ntau tshaj li lub sijhawm teev nyob hauv Cov Lus Qhia rau Siv.
• Tsis txhob muab xaum xaum hluav taws xob nrog rab koob txuas rau nws. Yog tias rab koob raug tso rau hauv qhov txuas, cov insulin tuaj yeem tawm ntawm tus cwj mem, lossis insulin yuav qhuav hauv rab koob, yog li txhaws lub koob, lossis cua npuas tuaj yeem tsim nyob rau hauv lub taub hau.
• Cov koob txhaj tshuaj uas siv uas tsis siv yuav tsum muab cia rau hauv tub yees ntawm qhov kub li 2 ° C txog 8 ° C. Tsis txhob siv cov xwj xem hluav taws xob yog tias nws tau khov.
• Cov kua xaum xeb uas koj tab tom siv yuav tsum cia nyob rau qhov kub tshaj li 30 ° C thiab hauv qhov chaw tiv thaiv los ntawm tshav kub thiab lub teeb.
• Xa mus rau cov lus qhia rau kev siv rau kev paub tiav nrog kev khaws cia cov qauv ntawm cov xaum xaum.
• Khaws cov xaum xaum kom deb ntawm qhov chaw ncav cuag ntawm cov menyuam.
• Muab cov koob txhaj tshuaj siv rau hauv cov hnoos qeev-tiv taus, lub thoob ntim rov qab (piv txwv li, cov khoom ntim rau biohazardous tshuaj lossis pov tseg), lossis raws li kev pom zoo los ntawm koj tus kws kho mob.
• Pov tseg cov xaum qhuav uas tsis siv koob uas txuas nrog lawv thiab ua raws li cov lus pom zoo los ntawm koj tus kws kho mob.
• Tsis txhob ntim cov thawv ntim ntim rau hauv cov ntse ntim.
• Nug koj tus kws kho mob seb yuav ua li cas thiaj li muaj cov thoob ntim hauv cov thoob koj thaj tsam.
• Cov txheej txheem rau kev tuav rab koob tsis hloov cov lus qhia pov tseg hauv zos, cov lus qhia pom zoo los ntawm koj tus kws kho mob lossis chaw haujlwm xav tau.

Yog tias koj muaj lus nug lossis teeb meem hais txog kev siv QuickPen Syringe Pen, ces hu rau koj tus kws kho mob.

Lub npe thiab chaw nyob ntawm cov chaw tsim khoom:
Eli Lilly thiab Tuam Txhab. USA

"Eli Lilly thiab Tuam Txhab",
Indianapolis, HAUV 46285, USA.

Eli Lilly thiab Tuam Txhab.
Khab. Indiana 46285. United States.

Sawv cev nyob Xos Viav:
"Eli Lilly Vostok S.A.", 123317. Moscow
Presnenskaya embankment, d. 10

Humalog®, Humalog® nyob rau hauv QuickPen syringe cwj mem Humalog® sib tov 50 hauv QuickPen ™ koob txhaj tshuaj, Humalog® sib xyaw 25 hauv QuickPen koob txhaj tshuaj yog cov cim lag luam ntawm Eli Lilly & Lub Tuam Txhab.

Lub QuickPen ™ syringe cwj mem ua tau raws li qhov tseeb kev noj tshuaj thiab kev ua haujlwm zoo ntawm ISO 11608 1: 2000