Cov tshuaj "Meridia" rau kom poob phaus thiab nws cov analogues

Txhawm rau kom poob ceeb thawj, ntau cov ntxhais thiab poj niam uas xav ua kom lawv cov duab nyob ze rau qhov zoo tagnrho, noj tshuaj tshwj xeeb. Qee qhov ntawm lawv muaj qee yam khoom xws li sibutramine. Raws li cov tshuaj yeeb tshuaj no, cov tshuaj Meridia rau kom poob phaus yog tsim.

Ua ntej poob phaus hauv txoj kev no, koj yuav tsum kawm ua ntu lus qhia cov lus qhia siv Meridia, muab hauv qab no.

Meridia: muaj pes tsawg leeg thiab txoj cai ntawm kev nqis tes ua

Cov tshuaj nquag siv ntawm cov tshuaj Meridia yog subatramine hydrochloride monohydrate. Raws li qhov txuas ntxiv, cov tshuaj muaj cov tshuaj xws li silicon dioxide, titanium dioxide, gelatin, cellulose, sodium sulfate, dyes, thiab lwm yam Cov ntsiav tshuaj feem ntau siv los kho cov neeg rog.

Cov tshuaj Meridia yog muaj nyob rau hauv daim ntawv ntawm tsiav tshuaj ntawm ntau yam tshuaj:

10 milligrams (lub plhaub muaj cov xim daj-xiav, dawb hmoov yog sab hauv),
15 milligrams (rooj plaub muaj xim dawb-xiav, cov ntsiab lus yog hmoov dawb).

Meridia slimming khoom muaj tag nrho cov khoom siv kho kom zoo thiab muaj cov teebmeem hauv qab ntawm lub cev:

nce qib ntawm serotonin thiab norepinephrine nyob rau hauv receptors ntawm lub paj hlwb,
suppresses qab los noj mov
muab ib tug zoo nkaus li ntawm tag nrho,
normalizes hemoglobin thiab ntshav qabzib feem ntau,
ua kom tshav kub ntau ntxiv ntawm lub cev,
normalizes lipid (rog) metabolism hauv,
stimulates lub tawg ntawm cov rog xim av.

Cov tshuaj ntawm cov tshuaj yog sai sai rau hauv lub plab zom mov, tawg rau daim siab thiab ncav cuag lawv qhov siab tshaj plaws hauv cov ntshav peb teev tom qab noj. Cov tshuaj yeeb dej caw ua kom muaj lub cev tawm hauv lub cev thaum tso zis thiab tso quav.

Kev ntsuas rau siv

Kev siv cov tshuaj Meridia yog qhia rau tib neeg raws li kev saib xyuas kev kho mob rau cov kab mob xws li:

alimentary rog, nyob rau hauv uas lub cev huab hwm coj Performance index ntau tshaj 30 phaus ib square meter,
Kev rog rog Alimentary, nrog mob ntshav qab zib mellitus lossis ua rau lub cev tsis ua haujlwm ntawm cov roj ntsha rog, uas lub cev qhov ntsuas nyhav tshaj 27 phaus ib square meter.

Cov lus qhia rau kev siv

Noj Meridia tsiav tshuaj raws li cov lus qhia, uas ib txwm txuas nrog cov tshuaj:

haus tsiav tshuaj ib hnub ib zaug (cov tshuaj tsis yog zom, tab sis ntxuav nrog ib khob dej huv),
nws yog qhov zoo tshaj plaws los siv cov tshuaj anorexigenic thaum sawv ntxov ua ntej noj mov lossis nrog zaub mov noj,
koob tshuaj txhua hnub ntawm Meridia yuav tsum yog 10 milligrams,
yog tias cov tshuaj muaj qhov thev taus zoo, tab sis tsis muab cov lus pom zoo (hauv ib hlis twg tus neeg mob lub cev hnyav dua li ob phaus), noj tshuaj txhua hnub tuaj yeem nce ntxiv rau 15 milligrams,
yog tias hauv thawj peb lub hlis ntawm kev noj tshuaj, qhov hnyav poob qis dua 5% (thaum tus neeg mob noj tshuaj ntsiav hauv qhov ntau npaum li 15 milligrams), kev siv tshuaj Meridia nres,
kev tshem tawm ntawm cov tshuaj ntsiav kuj tseem yuav tsum tau muaj nyob rau hauv cov neeg uas ib tug neeg tom qab poob phaus me me tsis pib hle tawm, tab sis, ntawm qhov tsis sib xws, nce phaus ntxiv (los ntawm peb phaus thiab siab dua),
kev siv cov tshuaj Meridia tuaj yeem tsis pub dhau 12 lub hlis sib law liag,
thaum noj cov tshuaj anorexigenic, tus neeg mob yuav tsum ua raws li kev noj haus, ua raws li cov pluas noj uas kws kho mob tau qhia thiab koom nrog kev kho mob lub cev, ib tug neeg yuav tsum muaj kev ua neej zoo li qub tom qab kev kho mob (txwv tsis pub, qhov tshwm sim tuaj yeem ploj sai),
cov menyuam ntxhais thiab poj niam uas muaj hnub nyoog yug menyuam thiab noj tshuaj Meridia, yuav tsum muaj kev tiv thaiv tsis pub muaj menyuam, siv kev tiv thaiv kom tsis txhob muaj menyuam yaus,
Meridia ntsiav tshuaj tsis pom zoo kom ua ke nrog kev haus cawv, kev sib xyaw ntawm ethyl cawv thiab cov tshuaj nquag ntawm cov tshuaj anorexigenic tuaj yeem ua rau muaj kev loj hlob ntawm cov kev tsis zoo uas ua rau muaj kev phom sij rau lub cev,
thoob plaws hauv kev kho mob, tus neeg mob yuav tsum tsis tu ncua soj ntsuam qib ntshav thiab lub plawv dhia, nrog rau kev saib xyuas cov ntsiab lus ntawm uric acid thiab lipids hauv cov ntshav,
siv cov tshuaj capsules, ib tus neeg yuav tsum tau ceev faj tshwj xeeb thaum tsav tsheb thiab ua haujlwm nrog cov thev naus laus zis ua cov tshuab, raws li cov tshuaj no tuaj yeem txo koj lub siab,
cov tshuaj yuav tsum tsis txhob noj ib txhij nrog ib qho tshuaj tiv thaiv kab mob siab.

Cov kev thaiv tsis zoo thiab cov tshwm sim

Tau txais anorexigenic tsiav tshuaj Meridia yog contraindicated rau hauv cov kab mob thiab cov tsos mob xws li:

kev puas siab puas ntsws (suav nrog rau cov mob tsis nco qab thiab bulimia),
kev quav yeeb tshuaj
cov mob ntshav siab
prostate adenoma
Cov kab mob loj ntawm lub plawv thiab cov hlab ntshav,
lub raum tsis ua hauj lwm
lactose intolerance,
muaj lub cev tsis haum rau lub tshuaj,
malfunctioning ntawm daim siab,
organic rog tshwm sim los ntawm hormonal tsis txaus, kev tsim cov qog thiab lwm yam zoo sib xws,
cov mob qog ua ntshav hnyav.

Tsis tas li, cov tshuaj no yuav tsum tsis txhob noj cov poj niam thaum cev xeeb tub thiab lactation, menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo, tus neeg laus dua 65 xyoo. Nrog rau kev ceev faj, tsiav tshuaj yog qhov tsim nyog rau cov neeg uas muaj kev puas ntsoog los yog nquag muaj los ntshav.

Cov tib neeg sim kho kev rog thiab raug tshem ntawm cov phaus ntxiv nrog kev pab ntawm Meridia slimming noj tshuaj yuav ntsib kev txhim kho kev phiv xws li:

tachycardia
siab nce
xeev siab
cem quav
qhov ncauj qhuav
ua txhaum ntawm saj
mob hauv cov hnyuv thiab lub plab,
tso zis muaj teeb meem
insomnia lossis tsaug zog tsaug zog ntau dua,
mob taub hau
mob lub sijhawm
gynecological los ntshav,
tsawg potency
leeg thiab leeg mob
khaus tawv nqaij thiab tawm pob,
ua xua rhinitis
o tuaj
kev pom, thiab lwm yam.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, cov tshuaj no yuav tsum tsis txhob noj, txij thaum tam sim no tsis muaj pov thawj txaus ntawm cov kev tshawb fawb txog kev nyab xeeb ntawm kev cuam tshuam ntawm Meridia rau ntawm tus me nyuam hauv plab.

Cov poj niam ntawm lub hnub nyoog yug menyuam yuav tsum siv kev tswj kom tsis txhob muaj menyuam thaum noj cov tshuaj.

Tsis txhob siv Meridia thaum lactation.

Kev sib txuam

Kev siv sibutramine tib lub sijhawm nrog cov tshuaj uas thaiv cov kev ua si ntawm CYP3A4 enzyme (ketoconazole, erythromycin, troleandomycin, cyclosporin) ua rau muaj ntshav nce ntau ntxiv ntawm sibutramine metabolites thiab nce siab hauv lub plawv los ntawm 2.5 npliag tauj ib feeb thiab ua rau muaj kev cuam tshuam los ntawm kev kho mob ntawm QT.

Rifampicin, phenytoin, carbamazepine, phenobarbital, dexamethasone thiab cov tshuaj tua kab mob macrolide tuaj yeem ua rau cov metabolism sibutramine ntau ntxiv.

Nrog rau kev siv ib txhij nrog cov tshuaj uas nce qib ntawm serotonin neurotransmitter hauv cov ntshav ntshav (xaiv serotonin reuptake inhibitors, sumatriptan, dihydroergotamine, hwj chim analgesics - pentazocine, pethidine, fentanyl, tshuaj tiv thaiv - dextromethorphan), txoj kev pheej hmoo ntawm kev txhim kho serotromone.

Meridia tsis cuam tshuam rau cov nyhuv ntawm tshuaj tiv thaiv hormonal. Cov ntaub ntawv hais txog kev sib txuam nrog tshuaj cuam tshuam nrog cov tshuaj siv rau ib lub sijhawm luv luv.

Thaum noj nws nrog cawv, tsis muaj nce ntxiv nyob rau hauv lub txiaj ntsig tsis zoo ntawm yav tom ntej. Txawm li cas los xij, kev haus dej cawv tsis tau ua ke nrog cov kev pom zoo noj zaub mov zoo thaum noj sibutramine.

Sab sij huam

Feem ntau, cov kev mob tshwm sim thaum pib kho mob (hauv thawj 4 lub lis piam). Lawv qhov mob hnyav thiab ua kom tsawg nrog lub sijhawm. Cov kev mob tshwm sim feem ntau me me thiab thim rov qab. Cov txheej txheem rau kev ntsuam xyuas qhov tshwm sim ntawm cov kev mob tshwm sim: feem ntau -> 10%, qee zaum 1 %10%, tsis tshua muaj 145/90 hli Hg) (kuj saib "Kev Ceeb Toom").

Hyperthyroidism (nce ua haujlwm ntawm cov thyroid).

Kev ua tsis zoo rau lub siab ua haujlwm.

Mob raum tsis zoo.

Benign prostatic hyperplasia (benign ntawm lub prostate nrog rau qhov tsim muaj cov zis seem).

Pheochromocytoma (qog-ua qog ua haujlwm ntawm lub qog adrenal).

Tsim muaj pharmacological, kev quav yeeb tshuaj thiab dej caw.

Cev xeeb tub thiab lactation.

Meridia 15 mg yuav tsum tsis txhob siv rau cov menyuam yaus thiab cov hluas hnub nyoog qis dua 18 xyoo thiab cov neeg laus dua 65 xyoo vim tias tsis muaj kev kawm txaus hauv kev kho mob.

Tsuas tshuaj thiab tswj hwm

Sab hauv, cov tshuaj ntsiav yuav tsum tau noj thaum sawv ntxov, yam uas tsis tau zom thiab haus dej kom ntau (ib khob dej). Cov tshuaj muaj peev xwm coj los noj ntawm lub plab khoob lossis ntxiv rau noj mov.

Thawj koob tshuaj yog 1 tshuaj ntsiav ntawm Meridia 10 mg txhua hnub. Hauv cov neeg mob uas ua tsis tau zoo rau kev noj tshuaj no (tus qauv yog qhov ua kom lub cev tsawg dua 2 kg hauv 4 lub lis piam), muaj kev tiv thaiv zoo, kev noj tshuaj txhua hnub tuaj yeem nce rau 15 mg. Hauv cov neeg mob uas ua tsis tau zoo rau kev noj cov tshuaj Meridia 15 mg (tus qauv yog qhov txo qis hauv lub cev qhov hnyav dua li 2 kg hauv 4 lub lis piam), kev kho ntxiv nrog cov tshuaj no yuav tsum tau tsum tsis ua ntxiv.

Yog tias koj hla kev noj cov tshuaj ntawm ib zaug ntawm 10 lossis 15 mg, koj yuav tsum tsis txhob noj ob zaug, tab sis koj yuav tsum tau noj cov tshuaj ntxiv mus raws li cov txheej txheem sau tseg. Kev kho yuav tsum tsis txhob txuas ntxiv rau ntau dua 3 lub hlis hauv cov neeg mob uas tsis teb zoo rau kev kho (qhov hnyav tsawg dua 5% ntawm thawj theem rau 3 lub hlis ntawm kev kho). Kev kho yuav tsum tsis txhob txuas ntxiv yog tias, nrog kev kho ntxiv, tom qab qhov ua tiav ntawm qhov hnyav hauv lub cev, tus neeg mob ntxiv 3 kg lossis ntau dua hauv qhov hnyav. Lub sijhawm kho nrog Meridia 10 lossis 15 mg yuav tsum tsis pub tshaj 1 xyoos (cov ntaub ntawv hais txog qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj rau lub sijhawm ntev dua yog tsis muaj).

Thaum lub sij hawm Meridia txoj kev kho, cov neeg mob tau qhia kom hloov lawv txoj kev ua neej thiab kev coj noj coj ua kom tom qab kev kho tiav tiav lawv paub tseeb tias qhov ua tiav ntawm qhov hnyav hauv lub cev tau khaws cia (yog tias cov kev cai no tsis tau soj ntsuam, qhov nce ntawm lub cev qhov hnyav dua thiab mus ntsib kws kho mob yog kev tsis pom zoo).

Cov lus qhia ntawm cov txheej txheem ntawm kev thov tshuaj thiab tshuaj yog suav tias yog siv tau kom txog thaum tus kws kho mob tau xaiv koj txoj kev cai tshiab rau kev noj tshuaj. Txhawm rau kom ua tau zoo, koj yuav tsum ua raws li cov kev cai noj tshuaj ntau npaum li cas.

Noj ntau dhau

Cov ntaub ntawv hais txog kev noj tshuaj tshaj ntawm sibutramine muaj tsawg. Cov kev qhia tshwj xeeb ntawm kev haus ib ce tsis paub meej, txawm li cas los xij, tseem muaj peev xwm tshaj tawm qhov tshwm sim los ntawm cov kev mob tshwm sim yuav tsum tau txiav txim siab.

Tsis muaj kev kho tshwj xeeb rau kev haus luam yeeb ntau dhau thiab cov tshuaj tua kab mob. Nws yog ib qho tsim nyog yuav tsum tau ua cov kev ntsuas dav dav uas tswj kev ua pa, kev ua haujlwm ntawm cov hlab plawv, txhawb kev kho mob, kev mob plab thiab kev siv hluav taws xob ua kom zoo nkauj. Nrog rau kev ua kom ntshav ntxiv thiab tachycardia, beta-blockers tuaj yeem raug kho.

Kev tiv thaiv kev nyab xeeb

Nws tsuas yog siv nyob rau hauv kev ntsuas tau zoo thiab muaj kev ceev faj tshwj xeeb. Yuav tsum tau muab tswv yim kho mob.

Hauv cov neeg mob noj Meridia, nws yog ib qho tsim nyog los tswj ntshav siab thiab lub plawv dhia. Hauv thawj 2 lub hlis ntawm kev kho mob, cov kev ntsuas no yuav tsum tau saib xyuas txhua 2 lub lis piam, thiab tom qab ntawd txhua hli. Hauv cov neeg mob uas muaj mob ntshav tawm (ntshav siab tshaj 145/90 hli Hg), kev saib xyuas ntawm cov ntsuas no yuav tsum tau ua tshwj xeeb thiab tshwj xeeb, yog tias tsim nyog, ntau zaus. Yog tias cov ntshav siab thaum rov ntsuas dua ob zaug dhau 145/90 hli Hg. kev kho mob yuav tsum tau muab ncua.

Ceev faj yuav tsum tau siv thaum siv ib txhij nrog cov tshuaj uas ua kom muaj QT ntu sij hawm (astemizole, terfenadine, amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol, cisapride, pimozide, sertindole, tricyclic antidepressantsT), thiab hauv cov xwm txheej uas tuaj yeem ua rau muaj kev cuam tshuam xws li hypokalemia thiab hypomagnesemia.

Thaum soj ntsuam kev kho mob tsis tu ncua ntawm tus neeg mob noj tshuaj, yuav tsum tau saib xyuas tshwj xeeb rau kev mob siab ntsws, mob hauv siab thiab o ntawm ob txhais ceg, txawm hais tias tsis muaj kev sib txuas ntawm kev siv Meridia thiab kev txhim kho ntawm thawj lub ntsws ntshav.

Nrog rau kev tiv thaiv huab ceev rau cov neeg mob vwm.

Nrog rau kev saib xyuas tshwj xeeb, Meridia yuav tsum raug kho rau cov neeg mob uas lub siab tsis ua haujlwm ntawm qhov mob me mus rau mob hnyav (kev nce siab ntawm sibutramine hauv cov ntshav plasma yog ua tau).

Muab hais tias tsis muaj zog metabolites ntawm cov tshuaj raug tawm los ntawm ob lub raum, nrog ceev faj, cov tshuaj yuav tsum tau siv rau hauv cov neeg mob uas muaj lub raum tsis ua haujlwm ntawm me me rau mob hnyav.

Nws yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj keeb kwm ntawm lub cev muaj zog lossis cov lus sib kis (kev tswj tsis tau tus kheej cov leeg nqaij, nrog rau cov leeg tsis ua haujlwm).

Cov tshuaj tiv thaiv kev tshem tawm yeeb tshuaj (mob taub hau, nce siab) yog qhov tsis tshua muaj. Tsis muaj ntaub ntawv qhia txog kev txhim kho ntawm tus mob huam yeeb tshuaj, kev tshem tawm tus mob los yog kev puas siab ntsws.

Thaum kho, koj yuav tsum tsis txhob haus cawv vim qhov xav tau ua raws kev noj zaub mov.

Nrog kev ceev faj, nws tau muab sau ua ke nrog cov tshuaj uas ua rau muaj ntshav siab thiab plawv dhia (nrog rau cov tshuaj siv txhawm rau hnoos, ua xua thiab mob khaub thuas).

Cov yeeb tshuaj ua yeeb yam rau lub hauv nruab nrab cov hlab ntsha tuaj yeem txwv cov kev ua haujlwm ntawm lub hlwb, lub cim xeeb, thiab kev sib pauv.Thiab txawm hais tias cov kev tshawb fawb tsis tau sau tseg txog cov nyhuv ntawm sibutramine rau cov haujlwm no, txawm li cas los xij ceev faj yuav tsum tau siv thaum kho cov tshuaj rau cov tsav tsheb thiab cov neeg uas muaj kev cuam tshuam nrog kev nce siab ntawm kev mloog.

Cov lus qhia tshwj xeeb

Cov tshuaj yuav tsum tsuas yog siv nyob rau hauv cov xwm txheej uas txhua qhov kev ntsuas los txo qhov hnyav hauv lub cev yog qhov tsis muaj txiaj ntsig (i.e., txo lub cev qhov hnyav tsawg dua 5 kg rau 3 hlis).

Kev kho yuav tsum tau nqa tawm tsuas yog ib feem ntawm txoj kev kho mob txhawm rau txo lub cev nyhav hauv kev saib xyuas ntawm tus kws kho mob nrog cov kev paub hauv kev kho kev rog. Txoj kev kho kom ncaj ncees suav nrog kev hloov pauv ntawm kev noj zaub mov noj thiab kev ua neej, uas tsim nyog los tswj kev ua tiav ntawm lub cev qhov hnyav tom qab tshem tawm txoj kev kho tshuaj.

Lub sijhawm noj cov tshuaj yuav tsum tau txwv nyob hauv lub sijhawm.

Cov lus qhia Meridia rau kev siv, contraindications, phiv, tshuaj xyuas

Ib cov tshuaj rau kev kho mob rog. Npaj: MERIDIA®

Cov tshuaj nquag ntawm cov tshuaj: sibutramine

ATX coding: A08AA10KFG: Cov tshuaj rau kev kho mob hauv nruab nrab cov npe sau npe: P No. 012145/01 Hnub sau npe: 02.26.06

Tswv reg reg. acc .: ABBOTT GmbH & Co. KG

Meridia tso tawm daim ntawv, ntim tshuaj thiab muaj pes tsawg leeg

Cov tawv gelatin tsiav tshuaj, nrog lub cev daj thiab lub hau xiav, nrog ib qho luam ntawm "10", cov ntsiab lus ntawm cov tshuaj ntsiav yog xim dawb los yog yuav luag dawb, yooj yim xoob hmoov. Capsules 1 lub kaus mom.

sibutramine hydrochloride monohydrate 10 mg Cov neeg tsis txaus siab: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigodyne (E132), titanium dioxide (E171), sodium lauryl sulfate, number case (grey), quinoline daj 7 pcs. - blister pob khoom (2) - pob ntawv ntawm cardboard. 14 pcs.

- blister packs (1) - pob ntawv ntawm cardboard. 14 pcs. - blister pob khoom (2) - pob ntawv ntawm cardboard. 14 pcs. - cov hlwv ntsej muag (6) - pob ntawv los ntawm daim ntawv tawv tawv Cov tawv tawv nkaws, nrog lub cev dawb thiab lub hau xiav, nrog ib daim ntawv tshaj ntawm "15", cov ntsiab lus ntawm cov tshuaj ntsiav yog xim dawb lossis yuav luag dawb, yooj yim xoob hmoov. Capsules 1 lub kaus mom.

sibutramine hydrochloride monohydrate 15 mg Cov neeg tsis txaus siab: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigotine (E132), titanium dioxide (E171), gelatin, sodium lauryl sulfate, number case (grey), quinoline daj. - blister pob khoom (2) - pob ntawv ntawm cardboard. 14 pcs.

- blister packs (1) - pob ntawv ntawm cardboard. 14 pcs. - blister pob khoom (2) - pob ntawv ntawm cardboard. 14 pcs. - blister packagings (6) - pob ntawv ntawm cardboard.

Cov lus piav qhia ntawm cov tshuaj yog ua raws cov lus qhia raug pom zoo rau kev siv.

Ib cov tshuaj rau kev kho mob rog. Sibutramine yog prodrug thiab exerts nws cov nyhuv hauv vivo vim yog metabolites (amines thawj thiab theem nrab) uas khis ntawm reuptake ntawm monoamines (feem ntau yog serotonin thiab norepinephrine).

Kev nce ntxiv ntawm cov ntsiab lus ntawm neurotransmitters hauv cov lus sib tham tau nce qhov kev ua haujlwm ntawm central 5-HT-serotonin thiab adrenergic receptors, uas ua rau muaj qhov nce ntawm qhov kev xav ntawm qhov muaj txhij txhua thiab txo qis ntawm kev thov khoom noj, nrog rau kev nce hauv thermal ntau lawm.

Los ntawm kev ua kom ncaj qha 3-adrenergic receptors, sibutramine ua rau ntawm daim ntaub adipose xim av.

Sibutramine thiab nws cov metabolites tsis cuam tshuam rau kev tso tawm ntawm monoamines, tsis inhibit MAO, tsis muaj kev sib raug zoo rau ntau ntawm cov neurotransmitter receptors, suav nrog serotonin (5-HT1, 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C), adrenergic (1 , 2, 3, 1, 2), dopamine (D1, D2), muscarinic, histamine (H1), benzodiazepine thiab NMDA receptors.

Kev nqus, muab faib, metabolism hauv Tom qab noj cov tshuaj hauv, sibutramine yog nqus sai sai los ntawm cov hnyuv. Lub sijhawm yuav ncav cuag Cmax ntawm sibutramine yog 1.2 teev.

Sibutramine yuav luag tiav hauv daim siab nrog rau kev koom tes ntawm CYP 3A4 isoenzyme nrog rau kev tsim cov mono- (dismethylsibutramine) thiab di-dismethyl (di-dismethylsibutramine) cov hom metabolites (M1 thiab M2), nrog rau los ntawm hydroxylation thiab conjugation nrog kev tsim ntawm.

Tom qab cov tshuaj noj ib zaug ntawm qhov tshuaj ntawm qhov tshuaj ntawm 15 mg, Cmax M1 thiab M2 yog 4 ng / ml (3.2-4.8 ng / ml) thiab 6.4 ng / ml (5.6-7.2 ng / ml), feem. Noj nrog zaub mov nce sijhawm kom ncav cuag thiab txo tus nqi ntawm Cmax dismethyl metabolites los ntawm 3 teev thiab 30%, feem, tsis cuam tshuam rau AUC tus nqi ntawm dismethyl metabolites.

Nws yog sai thiab zoo faib hauv cov ntaub so ntswg. Cov kab mob khi rau sibutramine - 97%, M1 thiab M2 - 94%.

T1 / 2 ntawm sibutramine - 1.1 teev, M1 - 14 teev, M2 - 16 teev. Nws yog feem ntau tawm los ntawm lub raum hauv daim ntawv ntawm tsis muaj zog metabolites.

hauv cov chaw kuaj mob tshwj xeeb
Hauv raum tsis ua haujlwm, lub ntsiab pharmacokinetic tsis sib haum (Cmax, T1 / 2 thiab AUC) tsis hloov pauv ntau.

Dosage thiab txoj hauv kev ntawm kev tswj hwm tshuaj

Qhov koob tshuaj tau muab teeb tsa ua ib leeg zuj zus, nyob ntawm qhov ua siab ntev thiab kev ua tau zoo hauv chaw kho mob. Thawj koob tshuaj yog 10 mg. Nrog cov txiaj ntsig tsis muaj txiaj ntsig (txo qhov hnyav hauv lub cev tsawg dua 2 kg hauv 4 lub lis piam), tab sis yuav raug txais kev zam zoo, kev noj tshuaj txhua hnub tuaj yeem nce rau 15 mg.

Yog tias, tom qab nce qhov koob tshuaj, qhov ua tau zoo ntawm cov tshuaj tseem tsis txaus (poob phaus tsawg dua 2 kg hauv 4 lub lis piam), kev kho mob txuas ntxiv yog qhov tsis tsim nyog. Daim hmoov tshuaj Meridia yuav tsum noj thaum sawv ntxov yam tsis muaj kev ntxo thiab haus dej kom ntau (ib khob dej). Cov tshuaj muaj peev xwm nqa tau ob qho tib si ntawm lub plab khoob thiab ua ke nrog noj mov.

Kev kho yuav tsum tsis txhob txuas ntxiv rau ntau dua 3 lub hlis rau cov neeg mob uas nyob rau lub sijhawm no (3 hlis) tsis muaj peev xwm ua tiav qhov txo lub cev hnyav ntawm 5% los ntawm thawj qib. Kev kho yuav tsum tsis txhob txuas ntxiv yog tias, nyob rau tom qab ntawm Meridia txoj kev kho, tom qab qhov ua tiav ntawm qhov hnyav hauv lub cev, tus neeg mob ntxiv 3 kg lossis ntau dua hauv lub cev qhov hnyav.

Lub sijhawm ntawm kev kho mob Meridia yuav tsum tsis pub tshaj 2 xyoos, vim tias tsis muaj ntaub ntawv qhia txog kev ua haujlwm thiab kev nyab xeeb ntawm kev siv rau lub sijhawm ntev dua ntawm kev siv tshuaj.

Feem ntau, cov kev mob tshwm sim thaum pib kho mob (hauv thawj 4 lub lis piam). Lawv qhov mob hnyav thiab ua kom tsawg nrog lub sijhawm. Cov kev mob tshwm sim feem ntau yog me me thiab thim rov qab Cov kev mob tshwm sim, nyob ntawm qhov tshwm sim ntawm cov kabmob thiab cov tshuab, tau hais hauv cov kev txiav txim hauv qab no: feem ntau -> 10%, qee zaum - 1-10%, tsis tshua muaj

Cov tshuaj rau kev kho mob hauv kev rog nruab nrab

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Cov tshuaj ntsiav tawv gelatin, nrog lub cev daj thiab lub hau xiav, nrog ib qho luam ntawm "10", cov ntsiab lus ntawm cov tshuaj ntsiav yog xim dawb lossis yuav luag dawb, yooj yim xoob hmoov.

1 lub kaus mom.
sibutramine hydrochloride monohydrate	10 mg

Cov muaj tswv yim: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigodyne (E132), titanium dioxide (E171), sodium lauryl sulfate, number case (grey), quinoline daj.

7 Pcs - blister pob khoom (2) - pob ntawv ntawm cardboard. 14 pcs. - blister packs (1) - pob ntawv ntawm cardboard. 14 pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.

14 pcs. - blister packagings (6) - pob ntawv ntawm cardboard.

Cov tshuaj ntsiav tawv gelatin, nrog lub cev dawb thiab lub hau xiav, nrog ib qho luam ntawm "15", cov ntsiab lus ntawm cov tshuaj ntsiav yog xim dawb lossis yuav luag dawb, yooj yim xoob hmoov.

1 lub kaus mom.
sibutramine hydrochloride monohydrate	15 mg

Cov muaj tswv yim: lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, indigotine (E132), titanium dioxide (E171), gelatin, sodium lauryl sulfate, number case (grey), quinoline daj.

14 pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.

Txhais tau tias yog rau kev noj qab nyob zoo

Cov tshuaj anorexigenic yog ib pawg tshuaj uas tswj kev qab los noj los ntawm cuam tshuam rau lub hauv nruab nrab lub paj hlwb. Muaj chaw ntawm kev tshaib kev nqhis thiab satiety nyob rau hauv lub hlwb. Cov tshuaj hauv cov pab pawg no muaj qhov ua rau lub zog chaw ntawm kev kub siab, tab sis tib lub sijhawm txwv qhov chaw ntawm kev tshaib plab. Cov nyhuv ntawm lub hauv nruab nrab lub paj hlwb tshwm sim los ntawm kev sib txuam ntawm serotonin thiab norepinephrine hauv hypothalamus. Vim qhov no, muaj kev tshaib kev nqhis muaj nqis.

Cov tshuaj anorexigenic uas ua rau tsis qab los noj mov tau muab faib ua adrenergic stimulants, stimulants ntawm serotonergic system thiab cov chaw sawv cev sib xyaw.

Cov kev thaiv tsis zoo thiab cov tshwm sim

Cov tshuaj anorexigenic yuav tsum siv nruj me ntsis raws li kws kho mob tau hais, vim tias cov tshuaj no yog siv rau qee tus neeg. Cov neeg mob twg yuav tsum tsis txhob haus cov nyiaj ntawm pawg no:

nrog mob ntshav siab
thyrotoxicosis,
mob ntsws hlwb,
keeb kwm ntawm lub plawv nres lossis hlab ntsha tawg,
malfunctions ntawm lub plawv,
circulatory mob,
mob ntsws
mob raws sijhawm.

Tsis tas li ntawd contraindications yog puas siab puas ntsws mob thiab pathological kev nyob rau hauv lub hauv paus poob siab, lub siab thiab lub raum tsis ua hauj lwm, insomnia thiab cev xeeb tub.

Yog tias dhau ntawm cov tshuaj no ntau dhau, tsis muaj zog, xeev siab, ntuav, lub qhov ncauj qhuav, zawv plab los yog raws plab, tso zis tsis meej, nce siab tsis meej, kiv taub hau, nce ntshav siab, tawm hws ntau dhau, ua xua tuaj yeem ua rau urticaria lossis Quincke's edema yuav tshwm sim.

Thaum cov tsos mob zoo li no tshwm sim, cov tshuaj ntawm cov tshuaj yuav tsum raug txo kom tsawg. Yog tias cov tsos mob tsis tau hloov pauv, koj yuav tsum tso tseg cov tshuaj tam sim ntawd thiab sab laj nrog kws kho mob kom kho qhov kev kho mob.

Cov tshuaj "Meridia"

Tus nqi ntawm cov khoom siv no zoo li muaj ntau yam txaus nyiam. Tom qab tag nrho, 700-800 rubles piv rau lwm cov tshuaj zoo sib xws pheej yug tsis tau. Cov tshuaj no yog txoj hauv kev zoo rau kev txo lub cev, muaj cov nyhuv sai. Cov tshuaj muaj tshuaj yog nyob hauv pab pawg neeg ntawm anorexigenic, txhim kho qhov kev xav ntawm tag nrho. Nws thaiv qhov rov ua kom zoo ntawm serotonin, norepinephrine, dopamine, ua rau muaj kev kho mob tsis zoo ntawm cov tshuaj. Nws yog siv rau kev rog nyob rau hauv qhov tsis muaj concomitant pathology, nyob rau hauv muaj qhov tsis txaus lipid metabolism thiab hom 2 mob ntshav qab zib.

"Meridia" muaj nyob hauv gelatin tsiav tshuaj ntawm 10 thiab 15 mg, 14 daim hauv 1 ntim. Kev ua kom tsis txhob noj tshuaj yog tshuaj tsis txaus siab ntawm pab pawg no, poob siab thiab lub hlwb tsis zoo, hormonal tsis ua haujlwm hauv lub cev, kab mob ntawm lub plawv thiab cov hlab ntsha, pathology ntawm lub raum, mob siab, lub qog gland.

Koj tuaj yeem txo qhov hnyav ntawm lub cev los ntawm kev noj 1 tshuaj ntsiav ntawm 10 mg txhua hnub. Yog tias cov tshuaj nqus tau zoo, qhov tshuaj txhua hnub tuaj yeem nce mus rau 15 mg. Lub chav kawm ntawm txoj kev kho yuav tsum tsis pub tshaj 1 xyoos. Meridia ntsiav tshuaj, tus nqi ntawm uas yog txog 700 rubles rau 14 tsiav tshuaj, tuaj yeem muas tau los ntawm cov tshuaj noj.

Qhov no yog cov tshuaj sib xyaw uas ib txhij inhibits qhov chaw ntawm kev tshaib kev nqhis vim metabolites thiab ua kom qhov chaw ntawm kev khov. Cov tshuaj siv 1 tshuaj ntsiav ib hnub. Cov koob tshuaj tau muab sau tawm ntawm tus kheej, nyob ntawm seb qhov hnyav dhau ntawm qhov hnyav thiab qhov mob ntawm lub cev. Feem ntau nws yog 10 mg. Cov ntsiav tshuaj Reduxin yuav tsum tau noj kom tsis muaj kev zom, kom huv si nrog dej kom ntau.

Cov ntsiab lus rau lawv siv: kev rog dhau qhov tsis muaj concomitant pathology, nyob rau hauv muaj ib qho tsis txaus lipid metabolism thiab hom 2 mob ntshav qab zib.

Reduxin ntsiav tshuaj yuav tsum tsis txhob siv los ntawm cev xeeb tub thiab lactating poj niam, cov neeg uas muaj pathologies ntawm qee yam kabmob. Hauv qhov no, yuav tsum tau sab laj kev sab laj ntawm cov kws tshaj lij yog qhov xav tau. Cov tshuaj tau sau tseg hauv kev ua raws nrog kev noj zaub mov noj txhua hnub thiab khoom noj khoom haus.

Cov tshuaj "Fepranon": cov lus qhia rau kev siv

Qhov no yog qhov tshuaj anorexigenic uas nws cov tshuaj muaj zog yog ampepramone. Nws ua kom lub chaw saturation, inhibits qhov chaw ntawm kev tshaib kev nqhis, txhim kho kev tshem tawm ntawm cov tsis tseem ceeb thiab txo qhov hnyav. Cov kev ua ntawm cov tshuaj manifests nws tus kheej tom qab 1 teev, nws ua txog li 8 teev, nkag mus zoo los ntawm cov ntshav-hlwb thiab placental teeb meem.

Kev taw qhia rau kev siv cov tshuaj yog alimentary rog thiab tsis txaus lipid metabolism vim kev cuam tshuam los ntawm hormonal cuam tshuam. Nrog rau cov thyroid pathology, nws yog siv ua ke nrog cov tshuaj thyroid.

1 ntsiav tshuaj ntawm cov tshuaj muaj 25 mg ntawm cov tshuaj nquag. Txog 80 mg yuav tsum tau noj ib hnub, qhov ntawd yog, 1 ntsiav tshuaj 2-3 zaug ib hnub. Koj yuav tsum haus lawv ib nrab teev ua ntej noj mov. Qhov siab kawg ntawm kev pub nkag yog 2 hli, chav kawm tuaj yeem rov ua tom qab 3 lub hlis. Cov tshuaj yog muab tshwj xeeb los ntawm tshuaj.

Nyob rau hauv rooj plaub ntawm kev noj haus ntau ntawm Fepranon, lub plawv dhia ceev ceev thiab ua tsis taus pa, hnov meej, thiab tsaus muag yuav tshwm sim. Yog tias koj noj cov tshuaj nrog qaug dab peg, koj tuaj yeem ua rau nrhoob, yog li nrog hom mob no, koj yuav tsum txwv tsis pub noj.

Cov tshuaj "Slimia"

Qhov no yog txhais tau rau qhov poob phaus, cov tshuaj muaj txiaj ntsig uas tau tiav ua tsaug rau cov tshuaj sibutramine nquag. Qhov cuam tshuam rau lub cev tshwm sim los ntawm kev ua kom nruab nrab ntawm qhov chaw siab txaus, txo kev tshaib kev nqhis thiab tom qab noj tsawg dua. Tsis tas li, cov tshuaj pab txhawm rau nce metabolism thiab sai dua tshem tawm cov tshuaj lom lom neeg hauv lub cev.

"Slimia" yog siv rau kev rog rog alimentary, rog rog ntshav qab zib thiab cov roj ntsha tsis txaus. Cov tshuaj yog contraindicated nyob rau hauv xws li mob:

nrog cov leeg hlab ntsha thiab hlwb tawg,
cuam tshuam kev rog rog
kab mob plawv thiab leeg,
pathology ntawm lub siab, ob lub raum, lub qog ua haujlwm,
kev quav cawv lossis quav cawv,
rau cov neeg muaj hnub nyoog 18 xyoo rov hauv
cev xeeb tub thiab lactating cov poj niam.

Tsis heev zoo tiv thaiv los ntawm lub cev "Slimia". Kev txheeb xyuas ntawm kev poob phaus qhia tau hais tias cov tshuaj muaj phiv nyob rau hauv daim ntawv ntawm kev mob plab zom mov, mob taub hau, tsaug zog, kiv taub hau feem ntau thaum pib ntawm txoj kev kho. Thaum muaj cov tsos mob zoo li no, koj yuav tsum sab laj tus kws kho mob tshwj xeeb txog kev tshem tawm tshuaj.

"Slimia" muaj nyob rau hauv cov ntsiav tshuaj 10 thiab 15 mg, qhov ntau ntawm cov tshuaj yog 1 ntsiav tshuaj hauv ib hnub. Lub chav kawm ntawm kev kho mob pib nrog 10 mg, yog tias cov txiaj ntsig yog qhov zoo, tom qab ntawd cov koob tshuaj tuaj yeem nce ntxiv rau 15 mg thiab ua tiav cov txiaj ntsig zoo hauv lub sijhawm luv.

Cov Tshuaj Pharmacokinetics

Sibutramine yog nqus tau los ntawm cov hnyuv thiab muaj cov "ua ntej" cuam tshuam los ntawm daim siab. Cmax ntawm cov tshuaj hauv plasma tau raug pom 1.2 teev tom qab ib leeg noj qhov ncauj ntawm 20 mg ntawm sibutramine.

Kev faib khoom thiab cov metabolism

Sibutramine yog metabolized los ntawm CYP3A4 isoenzyme rau demethylated metabolites M1 thiab M2. Pharmacologically nquag sib xyaw ntawm M1 thiab M2 ncav cuag Cmax tom qab 3 teev.

Nws tau qhia tias cov kab tawm ntawm kev sib deev tshwm sim hauv cov koob tshuaj ntau dua li 10 txog 30 mg, thiab tsis muaj kev hloov pauv ntawm T1 / 2, tab sis tsis muaj qhov nce ntawm cov tshuaj ntawm cov ntshav hauv ntshav plasma ncaj qha rau cov koob tshuaj.

Nrog kev rov qab noj ntau dua ntawm Css, cov metabolites M1 thiab M2 tau mus txog hauv 4 hnub, thiab yuav luag pom ob npaug tsub zuj zuj. Tus pharmacokinetics ntawm sibutramine thiab nws cov metabolites hauv cov neeg mob rog yog zoo li ntawd hauv cov neeg mob uas muaj lub cev hnyav.

Kev khi ntawm sibutramine thiab nws cov metabolites M1 thiab M2 rau cov ntshav protein tshwm sim nyob rau theem ntawm kwv yees li 97%, 94% thiab 94%, feem.

Thawj theem ntawm kev nthuav dav ntawm sibutramine thiab nws cov nquag metabolites M1 thiab M2 yog cov metabolism hauv lub siab. Lwm yam (ua haujlwm tsis tau) metabolites raug nthuav tawm feem ntau los ntawm lub raum, nrog rau los ntawm cov hnyuv hauv qhov sib piv ntawm 10: 1.

T1 / 2 ntawm sibutramine yog 1.1 teev, T1 / 2 ntawm metabolites M1 thiab M2 - 14 teev thiab 16 teev, ua ntu zus.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Tam sim no muaj cov ntaub ntawv tsawg tsawg tsis qhia txog qhov muaj sia nyob ntawm qhov sib txawv tseem ceeb hauv chaw muag tshuaj hauv txiv neej thiab poj niam.

Cov tshuaj pharmacokinetics pom nyob rau hauv cov neeg laus noj qab haus huv (hnub nyoog nruab nrab 70 xyoo) zoo ib yam li cov neeg mob hluas.

Lub raum tsis ua haujlwm tsis muaj kev cuam tshuam rau AUC ntawm cov tshuaj metabolites M1 thiab M2, tshwj tsis yog rau metabolite M2 hauv cov neeg mob uas mob rau lub raum tsis ua haujlwm rau lub raum lim ntshav.Lawv kev tshem tawm ntawm kev tsim cov tshuaj endogenous yog kwv yees li 2 zaug tsawg dua li cov neeg muaj kev noj qab haus huv (CL> 80 ml / min).

Hauv cov neeg mob uas muaj kab mob hepatic tsis txaus, AUC ntawm cov tshuaj metabolites M1 thiab M2 yog 24% siab dua tom qab siv tshuaj sibutramine ib zaug.

- rog rog rog nrog rog lub cev nyhav (BMI) ntawm 30 kg / m2 lossis ntau dua,

- Kev rog rog Alimentary nrog BMI ntawm 27 kg / m2 lossis ntau dua nyob rau hauv kev sib xyaw nrog hom 2 mob ntshav qab zib mellitus (tsis-insulin-kev vam khom) lossis dyslipoproteinemia.

Meridia: cov lus qhia rau kev siv lub ntsiav tshuaj

Meridia - noj tshuaj ntsiav uas muaj sibutramine. Qhov khoom no suppresses lub plab zom mov lipases, tiv thaiv kom tsis txhob rog los ntawm nqus thiab khaws cia hauv lub cev.

Cov tshuaj ntsiav tau siv los kho cov rog dhau los ntawm kev nyuaj thiab ib txwm muaj qhov hnyav hauv cov neeg mob uas muaj qhov tsis txaus ua rog rau cov rog dhau. Cov tshuaj muaj txiaj ntsig zoo, yog li ntawd, cov tshuaj yuav tsum nyob hauv kev saib xyuas kev noj qab haus huv.

Kev Sib Sau thiab daim ntawv ntawm tso tawm

Meridia muaj nyob rau hauv daim ntawv tshuaj ntsiav. Ib ntsiav tshuaj muaj 10-15 mg ntawm sibutramine.

Cov lus piav qhia Meridia hauv cov lus qhia - gelatin capsules muaj ob ntu ntawm daj thiab xiav. Sab hauv ntsiav tshuaj yog hmoov dawb.

Qhov muaj pes tsawg leeg ntxiv ntawm cov tshuaj ntsiav slimming Meridia:

E 104
Cov Ntsej Muag
E 171
E 132
CMK
E 572
E 172
Shellac
Propylene glycol
Mis qab zib
Nkaws
E 322
Dimethicone.

Hauv ib lub hlwv yog 14 lossis 28 tsiav tshuaj. Cov ntsiav tshuaj nrog cov lus qhia tau muab tso rau hauv lub thawv ntawv thawv.

Cov chaw muag tshuaj

Sibutramine yog ib lub teeb ci ntsa iab. Thaum pib, lub ntsiab lus tau muab tshuaj rau kev kho mob hauv kev puas siab ntsws, tab sis tom qab ntawd lawv pib siv cov tshuaj hauv kev kho kev rog.

Cov tshuaj Meridia cuam tshuam rau metabolites, uas yog theem nrab lossis thawj amines. Sibutramine suppresses reuptake ntawm neurotransmitters, yog li muaj lub siab tshaib plab thiab qhov zoo nkaus li ntawm qhov satiety.

Kev kho mob nyhuv tom qab siv Meridia tshwm sim tam sim ntawd, txij li cov tshuaj ntawm cov tshuaj cuam tshuam rau hauv nruab nrab ntawm kev khov kho hauv lub hlwb. Yog li thiaj li muaj qhov kev xav cuav ntawm tsis tseeb, uas txo cov khoom noj noj kom tsawg.

Lwm cov chaw muag tshuaj ntawm cov tshuaj:

Lowers cov rog, LDL, uric acid, triglycerides
Nce lipoproteins ntau ntom
Nws muaj qhov ua kom muaj zog anorexigenic.
Pab hlawv lipids, suav nrog cov rog rog
Txhim kho cov thermoregulation, vim tias lipolysis yog qhov ua kom muaj zog thiab cov txheej txheem hauv lub cev zom zaub mov.

Meridia rau kom poob ceeb thawj muaj lwm cov txiaj ntsig muaj txiaj ntsig - microcrystalline cellulose. Cov no yog coarse cov fibers uas ua raws li tus sorbent.

MCC normalizes cov txheej txheem ua haujlwm zom, tshem tawm quav, tshem tawm cov co toxins tawm hauv lub cev. Tsis tas li ntawd, cov pa tshuaj nyob hauv txoj hnyuv, uas txo kev tshaib plab.

Cia rau cov mob ntawm cov tshuaj Meridia

Hauv qhov chaw qhuav, ntawm qhov kub tsis tshaj 25 ° C.

Khaws tsis ncav cuag ntawm cov menyuam yaus.

Lub txee lub neej ntawm cov tshuaj Meridia yog 3 xyoos.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Meridia - ib cov tshuaj rau poob phaus, yog hais txog ib pawg tshuaj uas tswj kev qab los noj mov. Nws yog tsim los ntawm lub tuam txhab German Knoll AG.

Cov lus sib xyaw thiab cov txiaj ntsig ntawm cov tshuaj "Meridia" ntawm lub cev

Meridia yog tsim rau ntawm lub hauv paus ntawm ib yam khoom xws li sibutramine. Nws rhuav tshem qhov kev xav ntawm kev tshaib kev nqhis thiab ua rau muaj kev xav sai, kom ib tug neeg noj tsawg calories. Ntawm cov excipients ua Meridia, muaj cov khoom siv xws li lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate thiab lwm yam.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm tawv gelatin tsiav tshuaj nrog lub cev daj los yog dawb thiab lub hau xiav. Cov ntsiab lus ntawm cov tsiav tshuaj yog dawb-ntws dawb hmoov. Cov tshuaj ntsiav muaj 10 mg lossis 15 mg ntawm cov tshuaj nquag. Lawv muaj nyob rau hauv pob ntawm 14 thiab 28 ntsiav tshuaj.

Cov tshuaj noj zaub mov zoo Meridia muaj qhov cuam tshuam ncaj qha rau cov chaw ntawm lub hlwb, lub luag haujlwm rau kev ceev sai thiab kev cais tawm ntawm qab los. Tsis tas li ntawd, cov tshuaj no tsis tsuas yog tswj hwm thiab txo qis kev qab los noj mov, tab sis kuj txhim kho kev zom zaub mov, txo qis roj cholesterol, thiab normalizes tag nrho cov txheej txheem metabolic uas tshwm sim hauv tib neeg lub cev. Thaum noj Meridia, lub cev yuav tsum siv ntau lub zog, vim tias tseem muaj qhov txo qis hauv lub cev qhov hnyav.

Meridia tsiav tshuaj muaj cov khoom zoo:

Tsis tas noj zaub mov nruj thiab ua kom lub cev qoj ib ce hauv chaw tawm dag zog, kev noj cov tshuaj tso cai rau koj kom poob qhov nruab nrab li 10% thiab khaws qhov txiaj ntsig ntev.
Ua ntej tshwm sim hauv txee ntawm cov khw muag tshuaj, tshuaj tau raug kuaj hauv tsev kho mob.
Txais tos ntawm cov ntsiav tshuaj yog tus cwj pwm los ntawm kev yooj yim thiab kev yooj yim.
Cov kaus poom tau raug pom zoo thiab kev pom zoo rau muag thiab siv hauv ntau tshaj 26 lub teb chaws.

Tsis tas li ntawd, cov tshuaj Meridia ua rau hauv nruab nrab ntawm lub paj hlwb, txwv tsis pub noj mov thiab ua kom nrawm nrawm txheej txheem, nws txhim kho cov txheej txheem lipolysis, vim tias cov roj ntsha sib cais.

Yuav kom ua tiav qhov qhia tau zoo tshaj plaws, qhov tshuaj rau qhov poob phaus Meridia yuav tsum tau kawm nyob rau hauv ntev. Cov lus qhia tau qhia tias thawj qhov kev pib ntawm cov tshuaj yuav tsum yog 10 mg rau ib hnub. Yog tias thawj lub hlis qhov hnyav poob zoo - ntau dua 2 kg, koj yuav tsum tau noj nws txuas ntxiv ntawm qhov tshuaj no. Nyob rau hauv rooj plaub thaum lub cev hnyav dua li tsawg dua 2 kg hauv thawj lub hlis, tus neeg tsim khoom tsim kev pom zoo xav muab ntau dua rau 15 mg ntawm cov tshuaj ib hnub.

Ib chav kho mob yog 4 lub lis piam. Yog tias koj noj cov tshuaj tsawg dua 3 hlis, koj yuav tsis muaj peev xwm ua tiav qhov tshwm sim zoo, vim Meridia ua qeeb qeeb thiab muaj tus cwj pwm tsis txaus. Qhov ntau tshaj tawm qhov kev poob ceeb thawj yuav ua tiav rau lub hlis tom qab pib pib ntawm Meridia tsiav tshuaj.

Meridia slimming tshuaj muaj cov nram qab no contraindications:

hnub nyoog txog 18 xyoo
lub sijhawm cev xeeb tub thiab pub niam mis,
hnub nyoog 65 xyoos
lub raum thiab lub siab ua haujlwm,
mob plawv, tawg, kev ntshaus siab,
nrhiav lwm txoj kev kom poob phaus.

Ob peb qhov piv txwv ntawm Meridia paub, uas hauv sibutramine kuj tseem muaj. Ntawm cov analogues yog cov tshuaj xws li Denfluramine, Dexfenfluramine, Fluoxitine.

Sab Phiv, noj ntau dhau, sib cuam tshuam

Cov kev mob tsis zoo tom qab siv cov sibutramine ntau ntau tshwm sim hauv thawj 30 hnub ntawm kev kho mob. Raws li txoj cai, tom qab ib hlis ntawm kev siv cov ntsiav tshuaj, cov nyom hnyav dhau los ntawm lawv tus kheej.

Feem ntau, Meridia cuam tshuam lub plab zom mov, uas tau ua kom pom los ntawm kev tso quav, kub siab, exacerbation ntawm hemorrhoids, xeev siab.

Lwm qhov tsis zoo:

CNS - mob taub hau, xerostomia, ntxhov siab vim, pw ntxhov, dysgeusia, vetrigo
Qhov sib xyaws - ua pob ua npaws, kub taub hau, plhaw, los ntshav
Lub siab thiab cov hlab ntsha - tawg, kub ib ce, lub siab tuaj cuam tshuam nrog.

Qee zaum, Meridia ua rau muaj kev mob hnyav ntxiv uas yuav tsum tau muaj kev kho mob kom zoo. Cov kev tshwm sim no suav nrog kev qaug dab peg, mob hlwb tsis meej, kev tsim cov qog ua pob zeb, txo qis hauv platelet, capillarotoxicosis, thiab glomerular nephritis.

Txij li thaum noj sibutramine cuam tshuam rau kev ua haujlwm ntawm lub hlwb, nws tuaj yeem hloov qhov nco thiab ceev ntawm cov tshuaj tiv thaiv, rau lub sijhawm kho, koj yuav tsum tsis kam tswj xyuas cov txheej txheem nyuaj lossis thauj.

Kev overdose ntawm Meridia tsis tau tsim. Tej zaum, nyob rau hauv cov ntaub ntawv ntawm kev noj ib tug loj koob tshuaj, kev phiv rov tuaj yeem yuav tshaj tawm.

Thaum noj ntau dhau, kev kho tshwj xeeb tsis yog nqa tawm. Cov kws kho mob pom zoo saib xyuas cov haujlwm ntawm lub vascular thiab lub plawv, kom ntseeg tau tias ua pa pub dawb rau tus neeg mob. Yog tias tsim nyog, koj tuaj yeem nqa lub sorbent, kev ua lub plab zom mov. Nrog tachycardia lossis mob ntshav siab, beta-blockers tuaj yeem nqa tawm.

Kev sib cuam tshuam ntawm Meridia nrog lwm cov tshuaj:

CYP3A4 enzyme inhibitors - lub plawv dhia nce, cov ntsiab lus ntawm sibutramine metabolites hauv cov ntshav nce siab, QT luv lengthens
Macrolides, glucocorticosteroids, tshuaj tsaug zog, sedatives, ansamycins, normolytics, phenytoin - qhib sibutramine metabolism
Cov tshuaj tiv thaiv mob muaj zog, koob thib 3 koob tshuaj tiv thaiv kab mob, alpha-blockers, tryptamine derivatives - qhov muaj feem ntawm serotonin intoxication nce.

Cov tshuaj yeeb yaj kiab uas nrov ntawm cov tshuaj Meridia yog Reduxin thiab Goldline.

Chaw tsim tshuaj paus - Ozone, Russia

Nqi - los ntawm 1600 rubles

Kev piav qhia - tsiav tshuaj tau siv los kho kev rog kev rog nrog BMI ntawm 30 kg / m2

Pov thawj - yeej pab txhawb qhov kev poob phaus, tshem tawm qhov kev xav ntawm kev tshaib kev nqhis

Cons - muaj kev phom sij txaus ntshai thiab contraindications, tus nqi

Chaw tsim tshuaj paus - Izvarino-Pharma, Russia

Nqi - txij li 1200 txog 3500 rubles

Cov lus piav qhia - cov tshuaj ntsiav raws sibutramine thiab MCC tau noj rau cov rog rog txhawm rau tshem tawm kev tshaib plab

Pov thawj - lub cev hnyav tawm sai sai, txo qhov qab los noj mov, tsis ntxiv sib xyaw,

Cons - tus nqi, ua rau lub qhov ncauj qhuav thiab tso quav.

Meridia qab los tswj tus txheej txheem: muaj pes tsawg leeg thiab kev pom zoo hais txog kev siv tshuaj

Cov khoom noj tsis huv thiab tsis muaj dag zog ib txwm muaj peev xwm ib txwm ua rau ntau ntawm qhov hnyav thiab kev txhim kho kev rog dhau los.

Hauv qee kis, nws tsuas yog ua tsis yooj yim uas yuav daws qhov teeb meem zoo li no nrog kev pab ntawm kev ua kis las thiab kev noj haus.

Hauv cov xwm txheej zoo li no, cov kws qhia zaub mov noj tshuaj rau cov neeg mob tshwj xeeb rau lawv cov neeg mob kom txo lub cev qhov hnyav.

Ib cov tshuaj yog Meridia. Thaum siv raug, cov tshuaj no muab cov txiaj ntsig zoo thiab pab tib neeg poob phaus yam tsis muaj kev phom sij rau kev noj qab haus huv.

Tshuaj Meridia noj tshuaj nrog sibutramine hauv muaj pes tsawg leeg: haus dej lossis tsis haus?

Txhua tus neeg uas tau sim ua kom poob phaus rau lub sijhawm ntev paub: qhov twg pab tiag, tom qab ntawd cuam tshuam ntau rau kev noj qab haus huv. Thiab cov qauv kev nyab xeeb tshaj plaws yog qhov tsis muaj txiaj ntsig. Yog li ntawd, txhua tus neeg txiav txim siab rau nws tus kheej hauv txoj kev taw qhia twg los ua qhov kev xaiv.

Cov tshuaj Meridia, uas suav nrog tib sibutramine, ua rau koj xav txog cov ncauj lus no. Qhov yeeb tshuaj no, nyob ib puag ncig cov teeb meem loj uas tau tshwm sim rau ntau xyoo tam sim no. Kom haus los yog tsis haus cov tshuaj no kom dhau mus ua yuag?

Meridia ntsiav tshuaj tau ntim rau hauv cov thawv ntawv uas qhia lub ntsej muag nrog cov qauv siv tsis zoo (dawb, ib txoj kab liab xim dub rau sab hauv qab). Koj tuaj yeem nrhiav cov tuam ntxhab sib txawv: cov tshuaj yog tsim los ntawm ob lub tuam txhab Lavxias thiab kev txhawj xeeb hauv German.

Cov tsos mob - tawv gelatin tsiav tshuaj: daj (qhov sib xyaw ntawm cov tshuaj tseem ceeb 10 mg) lossis dawb (15 mg) lub cev nrog lub kaus mom xiav. Sab hauv yog hmoov dawb.

Cov kev ntim ib txwm - 14 daim ib lub hlwv, 2 lub hlwv hauv 1 ntim.

Muaj pes tsawg leeg suav nrog:

sibutramine (lub npe raug yog hydrochloride monohydrate) ua cov khoom uas nquag nquag, txhua tus so mus ua ntu zus,
sodium lauryl sulfate,
microcrystalline cellulose,
lactose monohydrate,
colloidal silicon dioxide,
magnesium stearate,
nkaws
titanium dioxide (E171),
indigotine (E132),
kua mem xim
quinoline daj zas xim (E104).

Koj yuav tsum to taub tias Meridia yog hluavtaws, thiab tsis yog ib txwm siv tshuaj nrog txhua qhov tshwm sim tom qab. Yog, thiab sibutramine-muaj.

Ntawm cov xwm txheej ntawm sibutramine. Txij li thaum Lub Ib Hlis 24, 2008, cov tshuaj no tau suav nrog hauv cov npe tshuaj muaj zog uas tau pom zoo los ntawm tsoomfwv Lavxias. Yog li, kev muag cov nyiaj muaj nws (suav nrog Meridia) raug tso cai tsuas yog los ntawm cov tshuaj (nrog cov qauv tshwj xeeb) thiab tsuas yog hauv cov khw muag tshuaj.

Ua rau lub cev

Qhov kev nqis tes ntawm cov ntsiav tshuaj yog ua raws cov nyhuv ntawm psychotropic ntawm sibutramine, uas lawv muaj. Nws ua li cas rau qhov poob phaus:

nws cov cuab yeej tseem ceeb pharmacological yog anorexigenic,
txo qhov qab los noj mov (txhim kho qhov kev xav ntawm cov fullness) thiab tus nqi ntawm cov zaub mov noj,
nce thermogenesis, vim uas cov metabolism thiab lipolysis leeb nrawm,
cuam tshuam cov nqaij rog
nce lub siab ntawm HDL hauv cov ntshav thiab txo qis cov roj triglycerides, roj cholesterol, uric acid, LDL.

Raws li kev txheeb cais, feem ntau cov neeg niaj hnub yog thawj dhau vim yog kev ua neej nyob tsis pub dhau thiab dhau hwv lawm. Thiab hauv qhov xwm txheej no, Meridia yog cov cuab yeej ntau rau kev poob phaus, uas yuav pab daws qhov teeb meem cag.

Sibutramine xa cov cim xa mus rau lub hlwb uas lub cev tau tsau, nws tsis xav noj lawm. Kev tshaib plab yog thaiv, thiab thaum noj mov tom ntej koj yuav tsis noj ib qho loj, vim tias koj yuav tsis xav tau.

Cov txiaj ntsig tau tuaj yeem ncav cuag 10 kg hauv ib lub hlis.

Qhia txog kev kho mob rau kev noj cov tshuaj Meridia yog:

alimentary (thawj) rog nrog lub cev loj ntawm ntau tshaj 30 kg / m2,
Kev rog rog rog Alimentary nrog lub cev qhov hnyav qhia pib ntawm 27 kg / m2 yog tias nyhav dhau heev lawm vim lub cev lipid metabolism tsis txaus lossis hom II mob ntshav qab zib mellitus.

Tsis txhob hnov qab tias cov tshuaj yog tshuaj thiab muag nruj me ntsis hauv cov khw muag tshuaj. Thaum xaj Meridia rau Is Taws Nem cov khoom siv thiab coj lawv tus kheej, yam tsis muaj kev tso cai los ntawm tus kws kho mob, koj ua lub luag haujlwm rau txhua qhov cuam tshuam.

Nqe yog $ 24 txog $ 52.

Qhov no los mas. Hauv kev tshawb fawb, vim qhov twg xyoo 2010 lawv tau ncua kev muag thiab tsim cov tshuaj sibutramine-suav tshuaj (suav nrog Meridia), cov tib neeg uas pib muaj teeb meem nrog lub siab thiab lub siab koom nrog. Nws tsis yog qhov xav tsis thoob tias thaum lub sijhawm kawg ntawm kev sim, lawv lub xeev kev noj qab haus huv tsis zoo.