Yuav siv Metformin Canon li cas?

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj. Muaj cov ntsiav tshuaj uas muaj 500 mg, 850 mg thiab 1000 mg ntawm metformin.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm 500 mg yog puag ncig, thiab cov ntsiav tshuaj nrog tshuaj ntau npaum 850 mg thiab 1000 mg (Metformin ntev) yog oval.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj.

1. Metformin hydrochloride.
2. Polyethylene glycol (macrogol).
3. Povidone.
4. Talc.
5. Sodium stearyl fumarate.
6. Sodium carboxymethyl hmoov txhuv nplej siab.
7. Pregelatinized hmoov txhuv nplej siab.
8. Opadry II dawb (zaj duab xis-tsim kev ncua).
9. Titanium dioxide.
10. Cawv polyvinyl.

Pharmacological kev txiav txim

Metformin inhibits gluconeogenesis, kev sib txuas ntawm cov khoom siv roj dawb, nrog rau cov txheej txheem ntawm lipolysis (rog tsis ua haujlwm) thiab rog oxidation. Nyob rau tib lub sijhawm, kev noj ntawm cov piam thaj hauv lub cev yog ua kom los ntawm kev nce siab ntawm cov kab mob ntawm cov cell mus rau insulin.

Cov tshuaj normalizes cov ntsiab lus ntawm triglycerides thiab roj nyob rau hauv cov ntshav. Muaj qhov maj mam poob hauv qhov hnyav hauv cov neeg mob rog.

Cov tshuaj tau pom zoo nyob rau hauv muaj mob thrombosis, txij li nws muaj cov nyhuv fibrinolytic. Metformin pab tshem tawm cov ntshav txhaws hauv cov hlab ntshav.

Cov tshuaj tau pom zoo nyob rau hauv muaj mob thrombosis, txij li nws muaj cov nyhuv fibrinolytic.

Cov Tshuaj Pharmacokinetics

Thaum noj ntawm qhov ncauj, cov tshuaj maj mam nqus tawm ntawm cov hnyuv. Metformin kev nqus yog 50%. Bioavailability tsis tshaj li 60%. Cov tshuaj mus txog nws qhov siab tshaj plaws hauv ntshav hauv 2-2.5 teev.

Metformin tsis muaj zog khi rau cov ntshav albumin, tab sis nkag sai sai rau cov kua nruab nrog cev. Nws yog tawm hauv lub cev los ntawm lub raum feem ntau tsis hloov. Lub sijhawm zam yog 8-12 teev.

Nws yog dab tsi rau?

Cov tshuaj yog tawm rau cov laus thiab cov menyuam yaus hnub nyoog 10 xyoo los ntawm kev rog dhau los thiab hom 2 mob ntshav qab zib mellitus (tsis-insulin-tsis cuam tshuam). Cov tshuaj yuav siv tau ob qho tib si thawj thiab theem nrab txhais tau tias (ua ke nrog insulin).

Lwm qhov kev qhia rau kev siv yog:

1. Kab mob siab hepatosis (mob siab ua pob). Ib tug kab mob hauv kev hloov pauv ntawm hepatocytes (mob siab hauv hlwb) rau daim tawv nqaij lipid tshwm sim.
2. Polycystic lub zes qe menyuam. Cov kab mob no feem ntau nrog los ntawm kev muaj peev xwm tiv thaiv cov tshuaj insulin. Ntau dhau ntawm cov khoom no thiab kev nce ntxiv hauv cov ntshav qab zib muaj tshwm sim.
3. Hyperlipidemia. Tus kab mob yog cim los ntawm cov ntsiab lus siab ntawm lipids thiab lipoproteins hauv cov ntshav.

Qhov qhia rau siv yog fatty hepatosis.

Cov Yuav Tsum Tau Ua

Cov tshuaj yog contraindicated nyob rau hauv cov ntaub ntawv hauv qab no:

• ib leeg tsis kam rau metformin lossis excipients,
• mob ntshav qab zib coma
• ketosis uas yog
• mob rau daim siab hnyav
• lub raum tsis ua hauj lwm zoo,
• zawv plab lossis ntuav heev,
• cov kab mob kis hnyav
• hypoxia
• npaws
• sepsis
• anaphylactic kev poob siab,
• myocardial infarction
• ua pa lossis lub plawv tsis ua haujlwm,
• quav cawv
• lactic acidosis,
• calorie tsis txaus
• cov menyuam yaus hnub nyoog txog 10 xyoo.

Noj cov tshuaj rau ntshav qab zib

Ua raws li cov lus qhia, cov neeg laus nrog kev kho mob monotherapy tau sau cia 1000-1500 mg ntawm cov tshuaj ib hnub. Yog tias tsim nyog, qhov tshuaj txhua hnub yog maj mam nce mus txog 2000 mg. Qhov siab tshaj plaws niaj hnub noj yog 3000 mg ntawm metformin. Qhov koob tshuaj txhua hnub tuaj yeem faib ua 2-3 koob.

Thaum ua ke nrog cov tshuaj insulin, qhov tshuaj ntawm Metformin yog 1000-1500 mg ib hnub. Thaum siv tshuaj kho, yuav tsum tau txhaj tshuaj kho cov tshuaj insulin.

Yuav noj rau qhov poob phaus li cas?

Txog kev kho mob rog, qhov ua rau uas yog insulin tsis kam, cov tshuaj yog kws kho nyob rau hauv thawj zaug ntawm 500 mg ib zaug. Qhov koob tshuaj tau nce rau 2000 mg rau ib hnub, ntxiv 500 mg txhua lub lis piam.

Metformin pab txo qhov hnyav thaum ua ke nrog kev noj zaub mov kom raug.

Metformin pab txo qhov hnyav thaum ua ke nrog kev noj zaub mov kom raug. Tab sis kev noj zaub mov nruj tsis tuaj yeem ua rau vim muaj qhov pheej hmoo ntawm cov ntshav qog ntshav qab zib.

Los ntawm ib sab ntawm cov metabolism

Ntxim rau cov metabolism:

• lactic acidosis,
• B12 tsis muaj peev xwm (tsis hnov ​​qab cov vitamin zom tau).

Cov lus qhia tshwj xeeb

Ua ntej kev ua haujlwm thiab kev kuaj mob uas siv cov tshuaj radiopaque, cov tshuaj kho mob raug muab tso tseg. Kev tshem tawm cov tshuaj yog nqa tawm 2 hnub ua ntej kev kuaj mob thiab tom qab ntawd rov pib dua tom qab 2 hnub.

Ua ntej kev phais mob, kev noj tshuaj raug muab tso tseg.

Siv thaum cev xeeb tub thiab lactation

Txij li cov tshuaj yeeb dej caw hla mus rau ntawm qhov txwv tsis pub, poj niam cev xeeb tub tsis pom zoo kom siv cov tshuaj no. Cov kev tshawb fawb uas ntseeg tau ntawm cov teebmeem teratogenic ntawm metformin tsis tau ua. Qee zaum cov kws kho mob sau cov tshuaj no rau poj niam cev xeeb tub yog tias tsim nyog.

Kev pub niam mis rau lub sijhawm kho yog qhov zoo kom nres.

Siv rau lub raum tsis zoo muaj nuj nqi

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj yog ua nrog ceev faj nrog cov tshuaj hauv qab no:

1. Danazole (hyperglycemic tus neeg sawv cev).
2. Chlorpromazine.
3. Cov tshuaj tiv thaiv.
4. Derivatives ntawm sulfonylureas.
5. NSAIDs.
6. Oxytetracycline.
7. ACE inhibitors thiab MAO.
8. Chaw kaw neeg.
9. Cov tshuaj hormones (nrog rau tshuaj tiv thaiv kom txhob muaj menyuam).
10. Diuretics (los ntawm pawg thiazide lossis voj diuretics).
11. Derivatives ntawm nicotinic acid thiab phenothiazine.
12. Glucagon.
13. Cimetidine.

Yog tias kev sib xyaw ua ke yog tsim nyog, tus kws kho mob kho cov koob tshuaj thiab tswj hwm qhov qab zib thiab lactic acid hauv cov ntshav.

Cawv tau zoo

Cov khoom no muaj qhov tsis zoo nrog haus cawv. Cov cawv yuav ua rau muaj kev phom sij ntawm cov nqaij hypoxia, cov kab mob lactic acidosis thiab lwm yam kev phiv.

Cov tshuaj yeeb yaj kiab uas nrov ntawm cov khoom no suav nrog Glucophage (Merck Sante, Fabkis), Formmetin (Pharmstandard, Russia), Siofor (Berlin-Chemie, Fabkis). Cov tshuaj no muaj tib qho kev ua haujlwm zoo - metformin hydrochloride.

Cov tshuaj xws li Metformin Teva thiab Metformin Richter yog tshuaj tua kab mob. Lawv zoo tib yam rau Metformin Canon nyob rau hauv muaj pes tsawg leeg thiab ua, tab sis yog tsim los ntawm lwm cov tuam ntxhab.

Kev txheeb xyuas ntawm Metformin Canon

Konstantin, hnub nyoog 42 xyoos, St. Petersburg

Kuv tau ua haujlwm li endocrinologist rau ntau dua 10 xyoo. Cov tshuaj no yog sau rau cov neeg mob ntshav qab zib thiab rog rog. Nws pab ua kom cov metabolism hauv thiab cov ntshav qabzib feem ntau. Kuv tsis tshua pom muaj kev phiv ntau hauv kuv xyaum.

Irina, 35 xyoo, Krasnodar

Metformin yog ib tus neeg sawv cev hypoglycemic zoo hauv kev kho mob ntshav qab zib hom 2. Kuv cov neeg mob zam cov tshuaj no zoo. Tom qab ib hlis tom qab noj cov ntshav qab zib cov tee. Txhawm rau kom tsis txhob mob plab, Kuv pom zoo kom tsis txhob noj cov tshuaj ntawm qhov khoob plab.

Hnub Valentine, 56 xyoo, Belorechensk

Kuv tau kawm txog cov tshuaj zoo li Metformin, Siofor, Glucofage los ntawm endocrinologist. Nws pom zoo kom lawv mus tua ntshav qab zib. Metformin cov txiaj ntsig zoo hauv kev sib piv nrog nws cov analogues yog nws tus nqi tsawg. Cov tshuaj tau pab thiab tsis ua rau muaj kev phiv.

Alexander, 43 xyoo, Volgograd

Kuv haus cov tshuaj no rau kev tiv thaiv mob ntshav qab zib. Cov ntshav qab zib tau pib sawv, thiab kws kho mob tau hais tawm Metformin. Kuv tsis pom muaj qhov tshwm sim tsis zoo thaum kho.

Ekaterina, 27 xyoo, Moscow

Tom qab yug menyuam tas, kuv tau pib zoo sai. Kuv tsis tuaj yeem ua raws li kev noj zaubmov kom ntev, yog li kuv txiav txim siab sim Metformin kom tsis qab los. Cov tshuaj tau pab tshem ntawm 5 kg hauv ib hlis. Tshaib plab npub, thiab kuv tsis tuaj yeem yauv.