Cov tshuaj Clindamycin: cov lus qhia rau kev siv

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm gelatin tsiav tshuaj muaj liab lub cev thiab lub hau liab. Cov tsiav tshuaj muaj cov hmoov dawb lossis daj daj. Txhua lub tshuaj ntsiav muaj 150 mg ntawm qhov nquag ua haujlwm ntawm clindamycin nyob rau hauv daim ntawv ntawm hydrochloride.

Talc, lactose monohydrate, magnesium starate thiab pob kws hmoov txhuv yog siv los ua cov khoom siv ntxiv.

Cov chaw muag tshuaj

Clindamycin muaj ntau yam kev cuam tshuam thiab yog cov kab mob bacteriostatic uas tiv thaiv cov txheej txheem ntawm cov protein ntau hauv cov kab mob pathogenic. Lub ntsiab lus tseem ceeb ua haujlwm tiv thaiv gram-zoo thiab microaerophilic cocci, nrog rau anaerobic gram-zoo bacilli, uas tsis ua rau spores.

Feem ntau hom clostridia tiv taus cov tshuaj tua kab mob no. Hauv qhov no, yog tias tus neeg mob tau mob los ntawm hom kab mob no, nws raug nquahu tias cov tshuaj tua kab mob ua ntej txiav txim siab.

Tom qab siv, cov tshuaj tam sim ntawd nqus rau hauv lub plab zom mov. Kev noj kom tsawg ntawm tus nqi nqus, tab sis tsis cuam tshuam rau kev txiav txim siab tag nrho ntawm cov tshuaj hauv cov ntshav. Cov tshuaj muaj qhov tsis zoo dhau los ntawm cov ntshav-hlwb teeb meem, tab sis nws yooj yim nkag mus rau cov ntaub so ntswg thiab kua dej xws li ntsws, qaub ncaug, tonsils, pleura, qhov txhab ntawm qhov txhab, hlab ntshav, hlab ntsws, mob pob txha thiab cov leeg nqaij, hnoos qeev, kua dej synovial, kua tsib lub plab, prostate caj pas, hnyuv tws. Nyob rau ntawm qhov muaj cov txheej txheem ua mob hauv cov hlab ntsha, qhov permeability ntawm cov tshuaj tiv thaiv kab mob los ntawm cov ntshav-hlwb teeb meem nce ntxiv.

Qhov siab tshaj plaws ntawm cov tshuaj yog pom nyob rau hauv cov ntshav ib teev tom qab siv ntawm tsiav tshuaj. Lub ntsiab tseem ceeb ntawm cov tshuaj yog tawm hauv lub cev rau 4 hnub nrog kev pab ntawm lub raum thiab hnyuv.

Kev ntsuas rau siv

Cov tshuaj yog tshuaj rau cov kab mob nram qab no:

• Kev tiv thaiv ntawm kev mob plab thiab peritonitis tom qab perforation lossis hnyuv raug mob,
• Tso quav
• Kev kis kab mob ntawm cov nqaij mos thiab tawv nqaij (panaritium, mob qog ntshav, mob viav vias, rwj), zoo li hauv lub qhov ncauj thiab lub plab (mob thiab mob rau daim tawv),
• Cov kab mob sib kis ntawm cov kab mob sab saud thiab ENT cov kabmob (sinusitis, pharyngitis, otitis media thiab tonsillitis), cov kab mob ntsws ua pa qis (pleural empyema, mob ntsws mob ntsws, mob ntsws thiab mob ntsws ua paug), mob qa foob, mob caws pliav,
• Endocarditis ntawm ib hom kab mob,
• Osteomyelitis nyob rau hauv ntu mob ntev lossis mob nyhav,
• Kev kis mob ntawm cov kabmob ntawm cov kabmob urogenital (tubo-ovarian inflammatory kev ua haujlwm, endometritis, mob chlamydia, mob paum ntawm qhov chaw mos),
• Cov kab mob kis nrog rau cov txheej txheem ua mob thiab tshwm sim los ntawm cov kab mob pathogenic yog qhov nkag siab cov tshuaj tua kab mob clindamycin.

Kev noj tshuaj ntxiv

Cov tshuaj ntsiav yog rau cov thawj coj ntawm qhov ncauj. Feem ntau tau hais kom noj ib koob tshuaj 150 mg nrog ncua sij hawm 6 lossis 8 teev. Yog tias tus neeg mob tiv thaiv los ntawm tus kab mob hnyav, ntau npaum li cas ntxiv tau ntau npaum li 300 lossis 450 mg. Thaum muab tshuaj rau cov menyuam yaus muaj hnub nyoog ib hlis, lawv tau coj los ntawm kev xam 8 lossis 25 mg rau ib phaus ntawm lub cev hnyav. Thaum nruab hnub yuav tsum yog 3 lossis 4 koob tshuaj.

Noj ntau dhau

Thaum siv cov tshuaj nyob rau hauv ntau npaum lub tshuaj kho mob, qhov tsis zoo tshwm sim tuaj yeem sib zog zuj zus.

Nyob rau hauv cov ntaub ntawv ntawm overdose, kev kho mob yog nqa tawm kev tswj hwm ntawm cov tsos mob. Nws yuav tsum tau yug hauv siab tias cov tshuaj no tsis muaj kev tiv thaiv, thiab kev lim ntshav thiab hemodialysis yuav tsis muaj cov txiaj ntsig tsim nyog.

Yeeb tshuaj sib cuam tshuam

Kev sib xyaw ua ke ntawm gentamicin, streptomycin, aminoglycosides thiab rifampicin ob leeg nce ntxiv cov kev ua tau zoo ntawm cov tshuaj saum toj no thiab clindamycin.

Ua ke nrog cov nqaij ntshiv uas sib tw, cov leeg ua kom cov leeg muaj zog, uas tshwm sim los ntawm anticholinergics, yuav nce ntxiv.

Cov tshuaj Clindamycin tsis tuaj yeem siv nrog cov tshuaj xws li magnesium sulfate, aminophylline, ampicillin, calcium gluconate thiab barbiturates.

Kev thaiv kev ua txhaum yog qhia piv rau chloramphenicol thiab erythromycin.

Nws tsis pom zoo kom siv cov tshuaj ua ke nrog cov tshuaj xws li phenytoin, vitamin B complexes, aminoglycosides.

Nrog rau txoj kev siv tshuaj tua kab mob ua ib ntsug, ua rau muaj kev ua pob txha caj dab ntev ntxiv.

Tsis nco qab siv cov tshuaj narcotic (opioid) analgesics yuav ua rau muaj kev nyuaj siab mob ntsws (txawm tias yog ua ntej ua pa).

Sab sij huam

Kev siv cov tshuaj tuaj yeem ua rau pom qhov tshwm sim ntawm cov kev mob tshwm sim hauv qab no:

• Lub plawv mob: kiv taub hau, zoo li tsis muaj zog,
• Hematopoietic plab hnyuv siab raum: thrombocytopenia, neutropenia, leukopenia, agranulocytosis,
• Cov kab mob plab zom mov: dysbiosis, ua kom lub siab ua haujlwm tsis zoo, mob txoj hlab pas, pseudomembranous enterocolitis, ntau ntxiv ntawm bilirubin, daj ntseg, daj, dyspeptic cuam tshuam,
• Kev ua xua tshwm sim: eosinophilia, urticaria, anaphylactoid manifestations, dermatitis, pruritus, tawm pob,
• Cov leeg cev: hloov pauv ntawm cov neuromuscular conduction,
• Lwm yam: superinfection.

Cov Yuav Tsum Muaj

Cov tshuaj yuav tsum tsis txhob sau tseg hauv cov xwm txheej hauv qab no:

• Siab rhiab heev rau ib qho tshuaj tiv thaiv,
• Lactation
• Muaj cov muaj mob kab mob tsawg,
• Hawb pob yog bronchial,
• Hnub nyoog qis dua 3 xyoos (menyuam lub cev qhov hnyav yuav tsum tsis pub tsawg tshaj 25 kg),
• Cev xeeb tub lub sijhawm
• Lub pob tw nyob hauv ib qho kev mob txhab
• Myasthenia gravis

Ceev faj yuav tsum tau siv thaum kev sau tshuaj rau cov neeg laus, ua rau muaj lub raum thiab lub siab tsis ua haujlwm.

Cov lus qhia tshwj xeeb

Tus mob pseudomembranous mob tuaj yeem tshwm sim ob qho tib si thaum kho thiab tom qab kawg ntawm kev kho. Ib qho kev tshwm sim tshwm sim nyob rau hauv daim ntawv ntawm zawv plab, mob leukocytosis, kub taub hau thiab mob ntawm lub plab (hauv qee kis, cov quav muaj cov hnoos qeev thiab ntshav).

Hauv cov xwm txheej zoo li no, nws txaus los mus thim cov tshuaj thiab sau cov tshuaj ion-txauv resins nyob rau hauv daim ntawv ntawm colestipol thiab colestyramine. Hauv cov mob hnyav ntawm tus kab mob no, nws yog qhov tsim nyog los them rau cov kua dej, cov protein thiab electrolytes thiab kom tsa metronidazole thiab vancomycin.

Thaum kho, nws yog contraindicated rau tshuaj kho uas inhibit plab hnyuv motility.

Kev nyab xeeb ntawm kev siv tshuaj Clindamycin hauv kev kho cov menyuam yaus tseem tsis tau ua tiav, yog li, nrog kev kho mob ntev hauv menyuam yaus, ntshav cov ntshav thiab kev ua haujlwm ntawm lub siab yuav tsum tau soj ntsuam tas li.

Thaum noj cov tshuaj hauv qhov ntau npaum, koj yuav tsum tswj hwm tus nqi ntawm clindamycin hauv cov ntshav.

Cov neeg mob uas ua rau lub siab ua haujlwm loj yuav tsum saib xyuas lub siab ua haujlwm.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Clindamycin muaj nyob rau hauv cov ntawv hauv qab no:

• Vaginal cream 2% - los ntawm dawb nrog lub creamy lossis daj daj rau kom dawb, nrog qhov tsis muaj ntxhiab tsw tsis meej (20 g thiab 40 g hauv txhuas cov leeg, 1 raj txhua tus nrog tus neeg thov),
• Nkaws tsiav tshuaj - nrog lub hau liab thiab ntshav xim, qhov loj me No. 1, cov ntsiab lus ntawm cov tshuaj ntsiav yog hmoov los ntawm daj-dawb rau dawb hauv xim (8 pcs. Hauv cov hlwv, 2 lub hlwv hauv pob ntawv cardboard, 6 pcs. Hauv cov hlwv, 2 hauv txhua, 5 thiab 10 blisters hauv cardboard pob),
• Kev daws rau kev txhaj tshuaj (txhaj tshuaj thiab tso ntshav) - pob tshab, daj me ntsis lossis xim tsis muaj xim (2 ml hauv ampoules, 5 ampoules hauv cov hlwv, 2 pob khoom hauv thawv ntawv).

Qhov muaj pes tsawg leeg ntawm 100 g ntawm lub paum ntawm lub paum muaj xws li:

• Cov tshuaj nquag: clindamycin (hauv daim ntawv ntawm ntsev) - 2 g,
• Ntu cov khoom siv: sodium benzoate, macrogol-1500 (polyethylene oxide-1500), roj taum castor, emulsifier No. 1, propylene glycol.

Cov muaj pes tsawg leeg ntawm 1 tshuaj ntsiav muaj xws li:

• Cov tshuaj kom nquag: clindamycin (nyob rau hauv daim ntawv ntawm hydrochloride) - 0.15 g,
• Ntu cov khoom xyaw: pob kws hmoov txhuv nplej siab, talc, lactose monohydrate, magnesium stearate,
• Cov sib xyaw ua ke ntawm cov tshuaj ntsiav: dub pob zeb diamond zas xim (E151), titanium dioxide (E171), azorubine zas (E122), quinoline daj zas xim (E104), ponce zas Ponceau 4R (E124), gelatin,
• Cov lus sib xyaw ntawm cov tshuaj ntsiav hauv lub cev: dub pob zeb diamond zas (E151), azorubine zas (E122), gelatin.

Cov lus sib xyaw ntawm 1 ml ntawm cov tshuaj rau txhaj tshuaj suav nrog:

• Cov tshuaj kom nquag: clindamycin (hauv daim ntawv ntawm phosphate) - 0.15 g,
• Ntu cov khoom siv: edetate disodium, benzyl cawv, dej rau kev txhaj tshuaj.

Tsuas tshuaj thiab tswj hwm

Txog cov kab mob ntawm cov mob loj tsawv rau cov neeg laus thiab menyuam yaus txij hnub nyoog 15 xyoos (hnyav txog 50 kg lossis ntau dua), Clindamycin raug xaj 1 ntsiav tshuaj (150 mg) 4 zaug hauv ib hnub ntawm kev ncua sijhawm. Hauv kev kis mob hnyav, ib zaug tshuaj tuaj yeem nce ntxiv 2-3 zaug.

Cov menyuam yau zog feem ntau tau sau tseg:

• 8-12 xyoo (hnyav - 25-40 kg): mob hnyav - 4 zaug hauv ib hnub, 1 tsiav tshuaj, ntau tshaj ib hnub - 600 mg,
• 12-15 xyoo (hnyav - 40-50 kg): qhov nruab nrab ntawm qhov mob hnyav yog 3 zaug hauv ib hnub, 1 tshuaj ntsiav, qhov mob hnyav ntawm cov kabmob - 3 zaug hauv ib hnub, 2 tsiav tshuaj, ntau tshaj plaws ib hnub - 900 mg

Qhov kev pom zoo ntawm cov neeg laus koob tshuaj rau cov tshuaj intramuscular thiab cov leeg ntshav yog 300 mg 2 zaug ib hnub. Hauv kev kho mob los ntawm kev muaj mob hnyav, 1.2-2.7 g ib hnub twg yog tau sau tseg, muab faib ua 3-4 koob. Kev siv tshuaj intramuscular ntawm ib zaug tshuaj ntau dua 600 mg tsis pom zoo. Qhov siab tshaj plaws rau kev txhaj tshuaj rau qhov ua dej num yog 1.2 g rau 1 teev.

Rau cov menyuam muaj hnub nyoog 3 xyoos, Clindamycin raug xaj rau ntawm 15-25 mg / kg ib hnub, muab faib ua 3-4 qhov kev tswj hwm sib luag. Hauv kev kho kab mob rau mob hnyav, kev noj tshuaj txhua hnub tuaj yeem nce ntxiv txog 25-40 mg / kg nrog tib zaus ntawm kev siv.

Hauv cov neeg mob uas mob raum thiab / lossis lub siab ua tsis tiav, nyob rau hauv kev siv cov tshuaj nrog kev ncua sij hawm tsawg kawg 8 teev, kev kho tshuaj ntau dua yog tsis xav tau.

Rau kev tswj hwm kev siv tshuaj, clindamycin yuav tsum tau diluted rau ib qho kev txiav txim siab ntawm tsis siab tshaj 6 mg / ml. Kev daws yog txhaj rau ua pa rau 10-60 feeb.

Tsis pom zoo txhaj tshuaj rau hauv qhov leeg.

Raws li cov kuab tshuaj, koj tuaj yeem siv cov kev daws teeb meem: 0.9% sodium chloride thiab 5% dextrose. Dilution thiab sijhawm ntawm Txoj kev lis ntshav yog pom zoo kom ua raws li cov txheej txheem (koob tshuaj / qhov hnyav ntawm cov tshuaj lom / lub sijhawm ntawm infusion):

• 300 mg / 50 ml / 10 feeb
• 600 mg / 100 ml / 20 feeb
• 900 mg / 150 ml / 30 feeb
• 1200 mg / 200 ml / 45 feeb.

Vaginal lee yog thov intravaginally. Ib koob tshuaj - ib qho tshuaj pleev ib ce tag nrho (5 g), nyiam dua ua ntej yuav mus pw. Lub sijhawm siv yog 3-7 hnub txhua hnub.