Tricor® (145 mg) Fenofibrate > Kev khomob thiab kev tiv thaiv

145 mg zaj duab xis-coated ntsiav tshuaj

Ib ntsiav tshuaj muaj

cov tshuaj heev - micronized fenofibrate 145 mg,

tus zam: hypromellose, sodium docusate, sucrose, sodium lauryl sulfate, lactose monohydrate, microcrystalline silonized cellulose, crospovidone, magnesium stearate.

plhaub muaj pes tsawg leeg: Opadry OY-B-28920 (polyvinyl cawv, titanium dioxide E171, talc, taum pauv lecithin, xanthan ntawm cov pos hniav).

Cov ntsiav tshuaj zoo li yob coated nrog cov xim dawb zaj duab xis, txho nrog "145" ntawm ib sab thiab tuam txhab logo ntawm lwm sab.

Pharmacological thaj chaw ntawm cov tshuaj Tricor 145 mg

fenofibrate yog ib qho kev tso dag ntawm fibroic acid. Nws cov nyhuv ntawm lipid profile, uas tau pom nyob rau hauv tib neeg, kev kho kom haum xeeb los ntawm kev ua kom muaj cov receptor ua kom los ntawm proliferating factor alpha hom peroxisome (PPARA).
Los ntawm kev ua haujlwm ntawm PPARα, fenofibrate nce kev siv ntawm lipolysis thiab tshem tawm TG-nplua nuj los ntawm cov ntshav ntshav los ntawm kev ua haujlwm ntawm lipoprotein lipase thiab txo qis hauv kev tsim ntawm apoprotein CIII. Kev ua kom zoo ntawm PPARα kuj tseem ua rau kev nce ntxiv hauv cov khoom cua ntawm apoproteins AI thiab II.
Qhov tau hais los ntawm fenofibrate ntawm LP ua rau txo qis ntawm cov zauv feem ntawm VLDL thiab LDL, uas muaj apoprotein B, thiab nce ntxiv hauv feem ntawm HDL, uas muaj apoproteins AI thiab II.
Tsis tas li ntawd, los ntawm kev hloov kho ntawm kev sib txuas thiab catabolism ntawm VLDL feem, fenofibrate tsub zuj zus ntawm kev tshem tawm ntawm LDL thiab txo cov nyiaj ntawm LDL, cov qib uas tau nce nrog atherogenic lipoprotein phenotype, uas feem ntau pom hauv cov neeg mob uas muaj kev pheej hmoo ntawm cov hlab ntshav txhaws.
Thaum lub sijhawm sim kho mob ntawm fenofibrate, theem ntawm cov roj (cholesterol) tag nrho qis los ntawm 20-25%, TG los ntawm 40-55%, thiab theem ntawm HDL cov cholesterol nce siab li 10-30%. Hauv cov neeg mob uas muaj hypercholesterolemia, uas theem ntawm LDL cov cholesterol raug txo qis li 20 by35%, tag nrho cov txiaj ntsig ntawm cov roj (cholesterol) cuam tshuam txog qhov txo qis ntawm tag nrho cov cholesterol mus rau HDL cholesterol, LDL roj cholesterol mus rau HDL roj cholesterol lossis apoprotein B rau apoprotein AI, uas yog cov cim ntawm atherogenic txaus ntshai.
Vim nws cov nyhuv ntawm LDL cov roj cholesterol thiab triglycerides, kev kho fenofibrate muaj cov txiaj ntsig zoo hauv ob qho tib si rau cov neeg mob thiab tsis muaj hypercholesterolemia txuam nrog hypertriglyceridemia, suav nrog cov kawm qib siab hyperlipoproteinemia, tib yam li tau kuaj pom nyob hauv hom II mob ntshav qab zib mellitus.
Txog rau tam sim no, tsis muaj ib qho tshwm sim ntawm kev tshawb nrhiav ntev dhau los ua kom pom kev ua tau zoo ntawm fenofibrate kev txheeb ze rau kev tiv thaiv kab mob thiab kev tiv thaiv ntawm cov mob atherosclerosis.
Kev tso tawm cov roj (cholesterol) ntawm cov roj (xanthoma tendinosum et tuberosum) tuaj yeem txo qis lossis ploj tag thaum lub sijhawm kho fenofibrate.
Hauv cov neeg mob uas muaj cov ntshav siab fibrinogen uas tau kho nrog fenofibrate, qhov kev txo qis tseem ceeb hauv qhov ntsuas no tau sau tseg. Lwm qhov cim ntawm qhov mob, xws li CRP, kuj tseem txo nrog kev kho fenofibrate.
Cov nyhuv uricosuric ntawm fenofibrate, uas ua rau txo qis uric acid ntau npaum li 25%, tuaj yeem raug txiav txim siab ntxiv qhov txiaj ntsig zoo ntxiv hauv cov neeg mob dyslipidemia nrog hyperuricemia.
Nws tau pom tias fenofibrate tuaj yeem txo qis platelet sib sau los ntawm adenosine diphosphate, arachidonic acid, thiab epinephrine.
145 mg Tricor ntsiav tshuaj muaj fenofibrate nyob rau hauv daim ntawv ntawm nanoparticles.
Xuas
Qhov siab tshaj plaws hauv cov ntshav ntshav tau tiav 2-4 teev tom qab kev tswj hwm ntawm qhov ncauj. Cov concentration hauv cov ntshav ntshav yog ruaj khov nrog kev kho tas li.
Tsis zoo li lwm qhov kev npaj fenofibrate, qhov siab tshaj plaws nyob rau hauv cov ntshav ntshav thiab qhov nqus ntawm cov tshuaj feem ntau, uas muaj fenofibrate nanoparticles, tsis cuam tshuam los ntawm kev noj zaub mov. Yog li no, cov ntsiav tshuaj ntawm Traicor 145 mg tuaj yeem siv tsis hais txog kev noj zaub mov.
Kev tshawb nrhiav txog kev nqus ntawm cov tshuaj, uas suav nrog kev tswj hwm ntawm 145 mg ntsiav tshuaj rau cov txiv neej thiab poj niam noj qab haus huv ntawm lub plab khoob thiab thaum noj mov nrog cov roj ntau hauv cov zaub mov, pom tias kev noj zaub mov tsis cuam tshuam rau qhov nqus (AUC thiab qhov siab plasma concentration) ntawm fenofibric acid.
Kev xa Khoom
Fenofibric acid muaj kev ua haujlwm siab ntawm kev khi rau ntshav ntshav albumin (ntau dua 99%).
Metabolism thiab kev lom zem
Tom qab kev tswj hwm ntawm qhov ncauj, fenofibrate tau nrawm nrawm los ntawm esterases mus rau qhov nquag metabolite ntawm fenofibric acid. Fenofibrate tsis hloov pauv hauv cov ntshav ntshav tsis tau kuaj. Fenofibrate tsis yog lub cev rau CYP 3A4 thiab tsis koom nrog hauv cov kab mob hepatic microsomal metabolism.
Fenofibrate tsuas yog tawm hauv cov zis nkaus xwb. Yuav luag txhua nrho raug tshem tawm hauv 6 hnub. Nws yog zais feem ntau hauv cov fenofibric acid thiab nws cov conjugate nrog glucuronide. Hauv cov neeg mob laus, tag nrho cov plasma tshem tawm ntawm fenofibric acid tsis hloov.
Kev tshawb nrhiav caj hlav tom qab noj ib koob thiab nrog lub sijhawm ntev kho pom tias fenofibrate tsis suav los ntawm lub cev.
Fenofibric acid tsis raug ntuag los ntawm hemodialysis.
Ib nrab-lub neej ntawm fenofibric acid los ntawm ntshav ntshav yog 20 teev.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

145 mg zaj duab xis-coated Tricor ntsiav tshuaj muaj 145 mg ntawm micronized fenofibrate nyob rau hauv daim ntawv ntawm nanoparticles.

Xuas. Tom qab qhov ncauj tswj hwm ntawm Tricor, 145 mg ntawm Cmax (qhov siab tshaj plaws) ntawm fenofibroic acid tau tiav tom qab 2-4 teev. Nrog rau siv ntev, kev saib xyuas ntawm fenofibroic acid hauv cov ntshav tseem nyob ruaj khov, tsis hais tus yam ntxwv ntawm tus neeg mob. Tsis zoo li cov qauv tsim ua ntej ntawm fenofibrate, Cmax hauv ntshav thiab tag nrho cov txiaj ntsig ntawm micronized fenofibrate nyob rau hauv daim ntawv ntawm nanoparticles (Tricor 145 mg) tsis nyob ntawm kev noj zaub mov zoo ib txhij (yog li ntawd, cov tshuaj muaj peev xwm noj tau txhua lub sijhawm, tsis hais kev noj zaub mov).

Fenofibroic acid yog khov kho thiab ntau dua 99% ua txhua yam rau cov plasma albumin.

Kev ntsuas phoo thiab nthuav tawm

Tom qab kev tswj hwm ntawm qhov ncauj, fenofibrate tau nrawm nrawm los ntawm esterases mus rau fenofibroic acid, uas yog nws cov ntsiab lus nquag metabolite. Fenofibrate tsis pom nyob hauv cov ntshav. Fenofibrate tsis yog lub cev rau CYP3A4, tsis koom nrog microsomal metabolism hauv lub siab.

Fenofibrate tsuas yog tawm hauv cov zis hauv daim ntawv ntawm fenofibroic acid thiab glucuronide conjugate. Tsis pub dhau 6 hnub. fenofibrate yog dhau los yuav luag txhua qhov. Hauv cov neeg mob laus, tag nrho kev tshem tawm ntawm fenofibroic acid tsis hloov. Ib nrab-lub neej ntawm fenofibroic acid (T1 / 2) yog kwv yees li 20 teev. Thaum hemodialysis tsis tshwm. Kev tshawb nrhiav qhov tseem ceeb tau pom tias fenofibrate tsis nthuav dav tom qab ib koob thiab nrog siv ntev.

Cov Tshuaj Hauv Tshuaj

Tricor yog qhov lipid-txo qis tus neeg sawv cev los ntawm pab pawg ntawm fibroic acid derivatives. Fenofibrate muaj peev xwm hloov cov ntsiab lus lipid hauv lub cev vim kev ua haujlwm ntawm PPAR-α receptors (alpha receptors ua haujlwm los ntawm peroxisome proliferator).

Fenofibrate txhim kho plasma lipolysis thiab kev ua haujlwm ntawm atherogenic lipoproteins nrog cov ntsiab lus siab ntawm triglycerides los ntawm kev ua haujlwm ntawm PPAR-α cov neeg txais, lipoprotein lipase thiab txo cov synthesis ntawm apoprotein C-III (apo C-III). Cov teebmeem tau piav qhia saum toj no ua rau txo qis ntawm cov ntsiab lus ntawm LDL thiab VLDL feem, uas suav nrog apoprotein B (apo B), thiab cov ntsiab lus ntawm HDL feem, uas suav nrog apoprotein A-I (apo A-I) thiab apoprotein A-II (apo A-II) Cov. Tsis tas li ntawd, vim kev txhim kho ntawm kev ua txhaum ntawm kev sib txuas thiab catabolism ntawm VLDL, fenofibrate tsub kom qhov kev tshem ntawm LDL thiab txo cov ntsiab lus ntawm cov me me thiab ntom ntawm LDL (kev nce hauv cov LDL raug pom hauv cov neeg mob uas muaj atherogenic lipid phenotype thiab cuam tshuam nrog kev pheej hmoo siab ntawm CHD).

Thaum cov kev tshawb fawb soj ntsuam, nws tau sau tseg tias kev siv fenofibrate txo cov qib ntawm cov roj cholesterol tag nrho los ntawm 20-25% thiab triglycerides los ntawm 40-55% nrog qhov nce ntawm qib HDL-C los ntawm 10-30%. Hauv cov neeg mob hypercholesterolemia, uas qib Chs-LDL raug txo qis 20-35%, kev siv cov fenofibrate ua rau txo qis hauv feem ntau: tag nrho Chs / Chs-HDL, Chs-LDL / Chs-HDL thiab apo B / apo A-I, uas yog cov cim ntawm atherogenic kev pheej hmoo.

Muaj pov thawj qhia tias cov fibrates tuaj yeem txo qhov ntau zaus ntawm cov xwm txheej cuam tshuam nrog cov kab mob plawv, tab sis tsis muaj pov thawj ntawm kev txo qis kev tuag txhua yam hauv kev tiv thaiv kab mob plawv lossis theem nrab.

Thaum kho nrog fenofibrate, kev tso nyiaj ntxiv ntawm XC (leeg thiab tubant xanthomas) tuaj yeem txo qis thiab txawm ploj tag. Hauv cov neeg mob uas muaj qhov nce siab ntawm fibrinogen kho nrog fenofibrate, qhov kev txo qis tseem ceeb hauv qhov ntsuas no tau sau tseg, ntxiv rau cov neeg mob uas muaj qib lipoproteins ntau ntxiv. Thaum kho kho fenofibrate, ib qho kev txo qis hauv kev saib xyuas ntawm C-reactive protein thiab lwm cov cim ntawm kev mob tshwm sim.

Rau cov neeg mob dyslipidemia thiab hyperuricemia, ib qho ntxiv kom zoo dua yog tias fenofibrate muaj cov nyhuv uricosuric, uas ua rau txo qis hauv cov concentration ntawm uric acid los ntawm 25%.

Hauv kev tshawb fawb soj ntsuam, fenofibrate tau pom tias txo cov platelet sib sau los ntawm adenosine diphosphate, arachidonic acid, thiab epinephrine.

Kev ntsuas rau siv

Ntxiv rau kev noj haus zoo nkauj thiab lwm yam tsis yog siv yeeb tshuaj

(kev tawm dag zog lub cev, poob phaus) hauv cov xwm txheej hauv qab no:

mob ntshav qab zib hypertriglyceridemia nrog lossis tsis muaj cov cholesterol tsawg

- sib xyaw hyperlipidemia nyob rau hauv muaj ntawm contraindications los yog intolerance rau statins

- sib xyaw hyperlipidemia nyob rau hauv cov neeg mob uas muaj mob plawv ntau ntxiv nrog rau cov statins uas tsis muaj txiaj ntsig zoo hauv kev kho cov triglycerides thiab cov roj cholesterol siab.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj Tricor 145 mg tau noj txhua lub sijhawm ntawm hnub, tsis hais txog kev noj zaub mov, lub ntsiav tshuaj yuav tsum nqos tag nrho, tsis tas yuav zom, nrog ib khob dej.

Hauv kev sib xyaw nrog kev noj haus, Tricor 145 mg yog tau sau nyob rau hauv cov chav kawm ntev, cov hauj lwm zoo uas yuav tsum tau saib xyuas tsis tseg.

Txoj kev kho kom zoo yog raug ntsuas siv cov txiaj ntsig ntawm lipid spectrum (tag nrho cov roj (cholesterol), cov roj cholesterol qis dua, triglycerides).

Yog tias tsis pub dhau 3 lub hlis tsis muaj kev txhim kho ntawm cov lipid profile, kev txiav txim siab yuav tsum tau muab rau lub sijhawm teem sijhawm ntxiv lossis kho lwm qhov kev kho mob.

Cov neeg laus yog 1 koob tshuaj ntawm Tricor 145 mg 1 zaug nyob rau ib hnub. Cov neeg mob noj 1 ntsiav tshuaj ntawm fenofibrate 200 mg tuaj yeem hloov mus rau kev noj 1 ntsiav tshuaj ntawm Tricor 145 mg rau ib hnub yam tsis muaj kev kho ntxiv kho.

Cov neeg mob uas noj ib ntsiav tshuaj ntawm fenofibrate 160 mg rau ib hnub, tuaj yeem hloov mus rau kev noj 1 ntsiav tshuaj ntawm Tricor 145 mg yam tsis muaj kev kho ntxiv.

Cov neeg laus cov neeg mob tsis tas ua rau lub raum tsis ua haujlwm, kev pom zoo rau cov neeg laus cov tshuaj yog pom zoo.

Kev siv cov tshuaj hauv cov neeg mob mob siab tsis kawm ntawv.

Sab sij huam

Cov kev tsis zoo hauv qab no tau pom thaum lub sijhawm tshuaj placebo (n = 2344):

- mob plab, xeev siab, ntuav, raws plab, pom pob (mob me)

- Kom daim siab transaminases

- txoj hlab ntshav ntsws nqhis, mob thiav ntsig

- Cov tawv nqaij ua kom lub cev tiv thaiv tau: ua pob khaus, khaus, urticaria

- myalgia, myositis, mob leeg, mob leeg tsis muaj zog

- nce ntxiv ntawm cov creatinine hauv cov ntshav

- txo qis hauv hemoglobin theem, txo qis hauv cov ntsiab lus ntawm leukocytes

- alopecia, kev tsis haum lub ntsej muag

- kev nce qib ntawm urea hauv cov ntshav ntshav

- hnov nkees, kiv taub hau

Cov kev mob tshwm sim thaum siv tom qab kev lag luam (tsis paub ntau zaus):

- daj ntseg, mob cholelithiasis (xws li cholecystitis, cholangitis, biliary colic)

cov tawv nqaij mob hnyav (piv txwv, erythema multiforme, Stevens-Johnson syndrome, tshuaj lom neeg mob ua paug)

Kev siv cov tshuaj Tricor 145 mg

Ua ke nrog kev kho kev noj haus, cov tshuaj yog npaj rau kev kho mob mus ntev, cov txiaj ntsig ntawm qhov yuav tsum tau saib xyuas los ntawm kev txiav txim siab seb cov qib lipids hauv cov ntshav ntshav (tag nrho cov roj cholesterol, LDL cholesterol, TG).
Yog tias tom qab siv cov tshuaj rau ntau lub hlis (piv txwv li 3 hlis), qib ntawm lipids hauv cov ntshav cov ntshav tsis tau poob qis, nws yog qhov yuav tsum xav txog kev teem caij kho ntxiv lossis lwm hom kev kho mob.
Koob tshuaj
Cov neeg laus
Qhov pom zoo koob tshuaj yog 145 mg (1 ntsiav tshuaj) ib hnub ib zaug. Cov neeg mob uas noj fenofibrate ntawm ib koob tshuaj 200 mg tuaj yeem hloov nrog 1 ntsiav tshuaj ntawm Tricor 145 mg yam tsis muaj kev xaiv ntxiv cov tshuaj.
Cov neeg laus cov neeg mob
Rau cov neeg laus dua, kev noj tshuaj rau cov neeg laus ib txwm pom zoo.
Cov neeg mob raum tsis ua haujlwm
Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum tau txo cov koob tshuaj. Cov neeg mob zoo li no tau qhia kom siv tshuaj uas muaj fenofibrate qis dua (100 mg lossis 67 mg).
Cov menyuam
Tricor 145 mg yog contraindicated rau kev kho mob rau menyuam yaus.
Mob siab
Kev siv cov tshuaj hauv cov neeg mob uas muaj lub siab tsis tau kawm.
Txoj kev ntawm daim ntawv thov
Cov ntsiav tshuaj yuav tsum nqos tag nrho nrog ib khob ntawm dej.
145 mg Cov ntsiav tshuaj Traicor tuaj yeem noj tau txhua lub sijhawm thaum nruab hnub, tsis hais txog ntawm cov khoom noj.

Cov Tshuaj Tiv Thaiv Tricor 145 mg

Hepatic tsis txaus (suav nrog biliary mob ntsws), lub raum tsis ua haujlwm, menyuam yaus, kev tiv thaiv kab mob rau lub cev fenofibrate lossis lwm yam ntawm cov tshuaj, photosensitivity lossis phototoxic cov tshuaj tiv thaiv thaum kho nrog fibrates lossis ketoprofen yav dhau los, muaj mob zais zis (mob gallstone).
Tricor 145 mg yuav tsum tsis txhob noj nyob rau hauv cov neeg mob uas muaj kev tsis haum rau cov txiv laum huab xeeb los yog cov roj ntsha leya, lossis lwm yam khoom muaj feem (muaj kev pheej hmoo ntawm kev tsis haum lub siab).

Phiv cov tshuaj Tricor 145 mg

Cov kev mob tshwm sim yog qhia los ntawm cov zaus hauv txoj kev no: ntau heev (1/10), feem ntau (1/100, ≤1 / 10), ua tsis xws luag (1/1000, ≤1 / 100), tsis tshua muaj (1/10 000, ≤1 / 1000), tsis tshua muaj tshwm sim (1/100 000, ≤1 / 10 000), suav nrog qee qhov xwm txheej.
Los ntawm cov mob hauv plab zom mov
Feem ntau: mob plab, xeev siab, ntuav, raws plab thiab pom pob txha, mob nyhav raws plab.
Cawv: pancreatitis.
Ntawm ib sab ntawm daim siab thiab cov hnyuv
Feem ntau: cov tshuaj nce ntshav nce me (saib cov lus qhia tshwj xeeb).
Tuaj yeem: kev tsim cov pob zeb hauv lub zais khoom.
Tsis tshua muaj tshwm sim: muaj mob rau daim siab. Yog tias cov tsos mob (xws li mob daj ntseg, khaus khaus) qhia tias muaj kab mob siab, kuaj ntshav yuav tsum tau ua kom paub tseeb hais tias kuaj mob thiab, yog tias tsim nyog, tsum tsis siv tshuaj (saib TSHUAJ TSHWJ XEEB).
Ntawm feem ntawm daim tawv nqaij thiab cov nqaij mos
Tsis tshua muaj tshwm sim: xoo pob, khaus, ua xua, lossis xaim hluav taws xob.
Tsis tshua muaj: alopecia.
Tsis tshua muaj heev: kev paub txog tawv nqaij nrog erythema, cov tsos ntawm vesicles lossis pob ntseg hauv thaj chaw ntawm daim tawv nqaij uas tau raug tshav ntuj lossis cov duab hluav taws xob ultraviolet tawg rau qee kis (txawm tias tom qab ntau lub hlis siv tsis muaj kev cuam tshuam).
Los ntawm cov leeg musculoskeletal
Tsis tshua muaj: diffuse myalgia, myositis, mob plab, thiab leeg tsis muaj zog.
Tsis tshua muaj heev: rhabdomyolysis.
Los ntawm cov hlab plawv system
Cuam Tshuam: venous thromboembolism (pulmonary embolism, leeg txoj hlab ntshav nqhis).
Ntawm ib feem ntawm cov ntshav system thiab lymphatic system
Tsis tshua muaj: txo qis hauv hemoglobin thiab cov qe ntshav dawb.
Los ntawm lub paj hlwb tawg
Tsis tshua muaj: kev sib deev tsis muaj zog, mob taub hau.
Ntawm ib feem ntawm cov txheej txheem ua pa, hauv siab thiab mediastinum
Tsis tshua muaj tshwm sim: mob ntsws ua mob ntsws.
Cov ntawv soj ntsuam tau
Cawv: muaj ntau cov ntshiab si creatinine thiab urea.

Cov lus qhia tshwj xeeb rau kev siv cov tshuaj Tricor 145 mg

Kev teem sij hawm ntawm 145 mg ntawm Tricor tshwj xeeb yog qhia nyob rau hauv muaj qhov pom tseeb concomitant txaus ntshai yam, xws li tawg (ntshav siab) thiab haus luam yeeb.
Thaum muaj mob hypercholesterolemia, ua ntej pib kho nrog TRICOR 145 mg, nws yog qhov tsim nyog los kho cov kev mob uas ua rau nws lossis tshem tawm lwm qhov laj thawj, xws li decompensated type II diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemia (piv txwv, nrog myeloma) ), hyperbilirubinemia, pharmacotherapy (kev tiv thaiv kab mob hauv qhov ncauj, corticosteroids, antihypertensive tshuaj, protease inhibitors rau kev kho mob HIV), kev haus dej cawv.
Cov txiaj ntsig ntawm kev kho mob yuav tsum tau tswj hwm los ntawm txiav txim siab txog qib ntawm lipids hauv cov ntshav cov ntshav (tag nrho cov roj cholesterol, LDL, TG). Yog tias cov txiaj ntsig tsim nyog tsis tau tiav rau ntau lub hlis (piv txwv, 3 hlis), nws yog qhov yuav tsum tau txiav txim siab txog kev teem caij kho mob ntxiv lossis lwm hom kev kho mob.
Hauv cov neeg mob hyperlipidemia uas noj tshuaj estrogen npaj lossis tshuaj tiv thaiv uas muaj estrogens, nws yog qhov yuav tsum tau kuaj xyuas seb puas yog hyperlipidemia yog thawj lossis theem pib keeb kwm, txij li kev siv tshuaj ntawm estrogen yuav muaj ntau ntxiv lipid.
Daim siab ua haujlwm
Ib yam li kev siv lwm cov tshuaj lipid-txo qis, kev nce hauv transaminase kev ua si tau pom nyob hauv qee cov neeg mob. Feem ntau, nws dhau los, me, thiab asymptomatic. Nws raug nquahu kom kuaj xyuas cov haujlwm ntawm hloov ntshav txhua 3 lub hlis thaum thawj 12 lub hlis ntawm kev kho. Xav tau los saib xyuas cov mob ntawm cov neeg mob uas tau qhia txog kev nce siab hauv qib ntawm hloov tsheb. Nrog rau kev nce qib ntawm AlAT thiab AsAT los ntawm ntau dua 3 zaug piv nrog kev txwv ntawm sab saud, cov tshuaj yuav tsum tau txiav tawm.
Kev mob caj dab
Hauv cov neeg mob uas tau noj fenofibrate, tau sau tseg tias muaj mob pancreatitis. Nws qhov tshwm sim tuaj yeem yog qhov tshwm sim ntawm kev kho mob tsis ua haujlwm rau cov neeg mob uas muaj mob hypertriglyceridemia, qhov cuam tshuam ncaj qha ntawm cov tshuaj lossis vim yog lwm qhov laj thawj, piv txwv li lub pob zeb hauv cov kua tsib lub plab lossis qhov cuam tshuam ntawm cov kua tsib lub plab.
Nqaij
Kev mob rau cov leeg, nrog rau cov mob uas tsis tshua muaj mob rhabdomyolysis, tau sau tseg nrog fibrates thiab lwm cov tshuaj lipid-txo qis. Nws nquag nce nrog hypoalbuminemia los yog lub raum tsis ua haujlwm. Qhov ua rau muaj kev phom sij rau cov leeg hauv cov neeg mob nrog tus mob myalgia, mob plab thiab leeg tsis muaj zog, nrog rau kev nce siab hauv CPK (5 zaug piv nrog cov cai), yuav tsum tau muab suav rau hauv. Hauv cov rooj plaub no, kev kho mob nrog TRICOR 145 mg yuav tsum tsis ua mus ntxiv.
Yog tias muaj qee yam ua rau txiav txim siab rau tus mob myopathy thiab / lossis rhabdomyolysis, suav nrog ntau dua 70 xyoo, mob nqaij hlav rau cov neeg mob lossis cov neeg hauv tsev neeg, mob raum, mob ntshav qab zib, lossis haus dej cawv, cov neeg mob yuav muaj kev pheej hmoo ntawm kev mob rhabdomyolysis. Hauv cov neeg mob no, nws yog ib qho tsim nyog yuav tsum ua tib zoo ntsuas cov txiaj ntsig thiab kev pheej hmoo ntawm kev kho nrog Tricor 145 mg.
Txoj kev pheej hmoo ntawm cov tshuaj lom rau hauv cov leeg yuav nce ntxiv yog tias cov tshuaj tau tawm ntawm tib lub sijhawm nrog lwm txoj hnyuv lossis HMG-CoA reductase inhibitor, tshwj xeeb tshaj yog nyob ntawm cov kab mob concomitant leeg. Yog li, nws tau nquahu kom coj los sib xyaw ntawm fenofibrate thiab statin tsuas yog rau cov neeg mob uas muaj kev mob ntshav siab ntau thiab muaj kev pheej hmoo siab tshaj plaws ntawm cov kab mob plawv rau qhov tsis muaj keeb kwm ntawm cov leeg mob thiab nqa tawm kev kho mob nyob rau hauv kev soj ntsuam ze ntawm kev muaj peev xwm ua rau muaj kev cuam tshuam ntawm cov leeg.
Raum muaj nuj nqi
Kev kho yuav tsum tsis ua ntxiv yog tias cov creatinine theem tau nce ntau dua 50% piv nrog qhov txwv qis dua ntawm ib txwm muaj. Nws raug nquahu kom xav txog qhov xav tau los saib xyuas cov qib creatinine thaum thawj lub hli tom qab pib kho.
Tricor 145 mg muaj lactose, yog li cov neeg mob uas muaj kab mob xws li galactose intolerance, Lapp lactase deficiency lossis glucose-galactose malabsorption yuav tsum tsis txhob noj cov tshuaj no.
Tricor 145 mg muaj sucrose, yog li cov neeg mob uas muaj kab mob xws li fructose intolerance, glucose-galactose malabsorption lossis sucrose-isomaltase tsis txaus yuav tsum tsis txhob noj cov tshuaj no.
Siv thaum cev xeeb tub thiab lactation
Cov ntaub ntawv tsim nyog ntawm kev siv fenofibrate thaum cev xeeb tub tsis muaj. Kev tshawb nrhiav tsiaj tsis tau teeb tsa cov kev cuam tshuam teratogenic. Embryotoxic teebmeem tau pom tias yog koob tshuaj lom rau leej niam. Kev pheej hmoo txaus ntshai rau tib neeg yog tsis paub, yog li, Tricor 145 mg tuaj yeem siv thaum cev xeeb tub tsuas yog tom qab ua tib zoo saib xyuas ntawm cov txiaj ntsig / kev pheej hmoo sib piv.
Tsis muaj ntaub ntawv qhia txog kev tso tawm fenofibrate thiab / lossis nws cov metabolites rau hauv niam mis, yog li ntawd, Tricor 145 mg yuav tsum tsis txhob noj los ntawm cov niam uas pub mis.
Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis ua haujlwm nrog lwm cov txheej txheem. Tsis muaj qhov cuam tshuam tau sau tseg.

Tshuaj sib cuam tshuam tshuaj Tricor 145 mg

Qhov ncauj anticoagulants
Fenofibrate ua rau cov nyhuv ntawm cov tshuaj tiv thaiv qhov ncauj thiab yuav ua rau muaj kev pheej hmoo los ntshav. Nws raug nquahu tias cov koob tshuaj anticoagulants raug txo los ntawm 1/3 thaum pib kho thiab tom qab ntawd nws nce zuj zus, yog tias tsim nyog, nyob rau hauv kev tswj hwm ntawm INR (qhov ib txwm muaj nyob thoob ntiaj teb).
Cyclosporin
Ntau qhov xwm txheej ntawm lub raum lub raum ua tau raug ceeb toom nrog kev siv fenofibrate thiab cyclosporine tib lub sijhawm, yog li ntawd, hauv cov neeg mob zoo li no, kev ua haujlwm raum yuav tsum ua tib zoo saib xyuas. Kev kho mob nrog TRICOR 145 mg yuav tsum tsum tsis ua hauj lwm thaum muaj kev cuam tshuam loj heev hauv chav kuaj.
HMG-CoA reductase inhibitors thiab lwm yam khoom fibrates
Txoj kev pheej hmoo ntawm cov leeg lom hnyav ua rau muaj zog ntau dua thaum siv nrog HMG-CoA reductase inhibitors lossis lwm cov fibrates. Qhov sib xyaw ua ke no yuav tsum tau siv nrog ceev faj thiab ua tib zoo saib xyuas cov tsos ntawm cov cim qhia ntawm lub cev tsis zoo ntawm cov leeg (saib TSHWJ XEEB TSHWJ XEEB).
Cytochrome P450 Enzymes
Kev Tshawb Fawb hauv vitro siv tib neeg mob hepatic microsomes, fenofibrate thiab fenofibric acid tsis yog cov tshuaj tiv thaiv cytochrome (CYP) P450 isoforms CYP 3A4, CYP 2D6, CYP 2E1 lossis CYP 1A2. Lawv yog cov tshuaj tiv thaiv tsis muaj zog ntawm CYP 2C19 thiab CYP 2A6 thiab muaj cov tsis muaj zog lossis tsis tshua mob uas cuam tshuam rau CYP 2C9 ntawm kev kho mob ntau, uas yuav tsum tau suav nrog thaum siv nrog tshuaj uas muaj metabolized nrog kev koom tes ntawm cov cytochrome P450 isoforms.