Maninil, Diabeton, Glidiab, Glurenorm, Amaril, Glucofage thiab lwm yam tshuaj kho ntshav qab zib

Glurenorm yog tshuaj uas muaj qhov ua kom lub ntsej muag tsis zoo. Ntshav qab zib Hom 2 yog ib qho tseem ceeb heev rau kev kho mob vim nws muaj ntau yam tshwm sim thiab muaj feem ua rau muaj kev nyuaj siab. Txawm hais tias ua lub ntsej muag me me hauv cov piam thaj hauv siab, qhov zoo li ntawm retinopathy, plawv nres lossis mob stroke ntau zog.

Glurenorm yog ib qho tsis tshua muaj kev phom sij hais txog kev phiv los ntawm cov neeg sawv cev antiglycemic, tab sis nws tsis qis qis dua rau qhov ua tau zoo rau lwm cov tshuaj hauv pawg no.

Kws Tshuaj

Glurenorm yog qhov ncauj ntshav hypoglycemic coj los hais lus. Cov tshuaj no yog sulfonylurea derivative. Nws muaj pancreatic zoo li ntxiv cov nyhuv ntxiv. Nws pab txhim kho cov tshuaj insulin ntau dua los ntawm kev cuam tshuam cov kua nplaum-mediated synthesis ntawm cov tshuaj no.

Hypoglycemic effect tshwm sim tom qab 1.5 teev tom qab kev tswj hwm tshuaj sab hauv, qhov siab ntawm cov nyhuv no tshwm sim tom qab ob rau peb teev, kav ntev li 10 teev.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm sab hauv ntawm ib qho tshuaj noj ib zaug, Glyurenorm yog nqus tau sai heev thiab yuav luag tag nrho (80-95%) los ntawm kev mob plab los ntawm kev nqus.

Cov tshuaj nquag - glycidone, muaj kev sib txuam zoo rau cov protein nyob hauv ntshav ntshav (tshaj li 99%). Tsis muaj cov ntaub ntawv hais txog kev hla lossis hla ntawm kev tso tawm ntawm cov tshuaj no lossis nws cov khoom lag luam metabolic ntawm BBB lossis ntawm lub tsho me nyuam, nrog rau kev tso tawm ntawm glycvidone mus rau hauv cov mis ntawm lub tsev laus thaum lactation.

Glycvidone yog 100% ua hauv daim siab, feem ntau los ntawm demethylation. Cov khoom lag luam ntawm nws cov metabolism yog devoid ntawm pharmacological kev ua si lossis nws tau hais tawm tsis muaj zog hauv kev sib piv nrog glycidone nws tus kheej.

Feem ntau cov khoom siv glycidone metabolism tawm hauv lub cev, ua rau dhau ntawm txoj hnyuv. Ib qho me me ntawm cov khoom tawg uas tawg ntawm cov khoom tawm los ntawm lub raum.

Cov kev tshawb fawb pom tias tom qab kev tswj hwm sab hauv, kwv yees li ntawm 86% ntawm cov tshuaj isotope uas tso tawm los ntawm txoj hnyuv. Tsis hais txog qhov loj npaum li cas ntawm cov koob tshuaj thiab cov txheej txheem ntawm kev tswj hwm los ntawm ob lub raum, kwv yees li 5% (nyob rau hauv daim ntawv ntawm cov khoom lag luam metabolic) ntawm cov tshuaj uas lees txais yuav raug tso tawm. Qib ntawm kev tso tshuaj tawm los ntawm ob lub raum tseem nyob ntawm qhov tsawg txawm tias muaj kev noj tshuaj nyob rau niaj hnub.

Cov tshuaj Pharmacokinetics zoo ib yam rau cov neeg laus thiab tib neeg laus.

Ntau tshaj 50% ntawm glycidone raug tso tawm los ntawm txoj hnyuv. Raws li qee cov ntaub ntawv, cov tshuaj metabolism hauv lub cev tsis hloov pauv txhua txoj kev yog tias tus neeg mob lub raum tsis ua haujlwm. Txij li glycidone tawm hauv lub cev los ntawm ob lub raum mus rau ib qho tsawg heev, hauv cov neeg mob uas lub raum tsis ua haujlwm, cov tshuaj tsis txuam hauv lub cev.

Ntshav qab zib Hom 2 nyob rau hauv nruab nrab thiab hnub nyoog laus.

Cov Yuav Tsum Tau Ua

• Yam 1 ntshav qab zib
• Mob ntshav qab zib Acidosis
• Mob qab zib coma
• Lub siab ua haujlwm tsis zoo
• Ib qho kis mob
• Hnub nyoog qis dua 18 xyoo (vim tias tsis muaj ntaub ntawv hais txog kev nyab xeeb ntawm Glyurenorm rau pawg neeg mob no),
• Cov tib neeg lub cev muaj qhov tso tshuaj sulfonamide.

Ntxiv kev ceev faj yog yuav tsum tau thaum noj Glyurenorm nyob ib puag ncig pathologies hauv qab no:

• Ua npaws
• Mob qog noj ntshav
• Kev haus cawv mus ntev

Glurenorm yog npaj rau kev siv sab hauv. Yuav tsum ua raws li txoj cai kho mob thiab muab zaub mov rau noj. Koj tsis tuaj yeem txwv qhov kev siv Glyurenorm yam tsis tau sab laj nrog koj tus kws kho mob.

Thawj zaug tshuaj yog ib nrab tshuaj noj nrog pluas tshais.

Glurenorm yuav tsum tau noj nyob rau theem pib ntawm kev tau txais zaub mov.

Tsis txhob hla khoom noj tom qab noj cov tshuaj.

Thaum noj ib nrab ntsiav tshuaj yog qhov ua tsis muaj txiaj ntsig, koj yuav tsum tau sab laj nrog kws kho mob uas, feem ntau, yuav maj mam nce qhov ntau ntxiv.

Thaum hais txog kev muab tshuaj ntau dua li cov kev txwv saum toj saud, ib qho txiaj ntsig ntxiv tuaj yeem ua tiav yog tias ib koob tshuaj txhua hnub tau muab faib ua ob lossis peb koob tshuaj. Hauv qhov no, qhov loj tshaj plaws yuav tsum tau noj thaum noj tshais. Kev nce ntxiv rau koob rau plaub lossis ntau daim ntawv sau tauj ib hnub, raws li txoj cai, tsis ua rau muaj kev nce siab hauv kev ua haujlwm.

Qhov siab tshaj plaws hauv ib hnub yog plaub ntsiav tshuaj.

Rau cov neeg mob ua lub siab tsis zoo

Thaum siv cov tshuaj hauv koob tshuaj ntau dua li 75 mg rau cov neeg mob uas ua rau mob tsis haum xeeb, kev saib xyuas los ntawm tus kws kho mob yog qhov tsim nyog. Glurenorm tsis tuaj yeem noj nrog qhov muaj kab mob siab rau ntshav hnyav, vim 95 feem pua ​​ntawm cov tshuaj yog ua tiav hauv lub siab thiab tawm hauv lub cev los ntawm cov hnyuv.

Noj ntau dhau

Qhov tshwm sim: nce hws, tshaib plab, mob taub hau, txob taus, insomnia, tsaus muag.

Kev Kho Mob: Yog tias cov tsos mob ntawm lub qog ntshav qab zib tau tshwm sim, yuav tsum muaj cov piam thaj sab hauv lossis cov khoom lag luam muaj cov carbohydrates ntau. Hauv kev mob ntshav qab zib heev (nrog rau kev tsaus muag lossis hnov ​​qab), txoj kev tswj hwm ntawm dextrose yog tsim nyog. Tom qab rov qab nco qab, kev siv cov khoom noj khoom haus tau yooj yim ntawm cov carbohydrates yog qhia (rau kev tiv thaiv ntawm kev rov ua qog ntshav qab zib).

Kev sib txuam ntawm Pharmacological

Glurenorm tuaj yeem txhim kho qhov ua haujlwm hypoglycemic yog tias nws raug coj ua sai nrog ACE inhibitors, allopurinol, tshuaj kho mob, chloramphenicol, clofibrate, clarithromycin, sulfanilamides, sulfinpyrazone, tetracyclines, cyclophosphamides noj ntawm qhov ncauj los ntawm cov tshuaj hypoglycemic.

Tej zaum yuav muaj lub zog ntawm cov nyhuv ntshav hypoglycemic nyob rau hauv cov ntaub ntawv ntawm concomitant siv glycidone nrog aminoglutethimide, sympathomimetics, glucagon, thiazide diuretics, phenothiazine, diazoxide, ntxiv rau cov tshuaj uas muaj nicotinic acid.

Cov lus qhia tshwj xeeb

Cov neeg mob ntshav qab zib yuav tsum ua raws nraim li cov lus qhia ntawm tus kws kho mob saib xyuas. Nws yog qhov yuav tsum tau ua tib zoo tshaj plaws los tswj cov xwm txheej thaum xaiv cov koob lossis hloov mus rau Glyrenorm los ntawm lwm tus neeg sawv cev uas tseem muaj cov nyhuv hypoglycemic.

Cov tshuaj uas muaj cov nyhuv hypoglycemic, noj ntawm qhov ncauj, tsis muaj peev xwm ua qhov hloov tag rau kev noj zaub mov noj uas tso cai rau koj los tswj tus neeg mob lub cev qhov hnyav. Vim tias tsis noj zaub mov los yog ua txhaum cov kws kho mob cov tshuaj yuav ua rau cov ntshav qabzib poob, ua rau tsaus muag. Yog tias koj noj tshuaj ua ntej noj mov, es tsis txhob noj thaum pib noj mov, cov nyhuv ntawm Glyrenorm ntawm cov ntshav qabzib muaj zog dua, yog li ntawd, qhov yuav ua rau muaj ntshav qog ntshav nce ntxiv.

Yog tias hypoglycemia tshwm sim, kev noj cov zaub mov sai sai uas muaj cov piam thaj ntau yog xav tau. Yog tias cov ntshav qog ntshav qab zib tseem nyob, txawm tias tom qab qhov no koj yuav tsum nrhiav kev pab kho mob sai.

Vim yog kev ntxhov siab ntawm lub cev, cov nyhuv hypoglycemic yuav nce ntxiv.

Vim tias qhov ua kom haus dej cawv, qhov nce ntxiv lossis txo qis hauv cov nyhuv hypoglycemic yuav tshwm sim.

Glyurenorm ntsiav tshuaj muaj lactose hauv ib qho 134.6 mg. Cov tshuaj no yog contraindicated nyob rau hauv cov neeg kev txom nyem los ntawm qee cov keeb kwm kab mob.

Glycvidone yog sulfonylurea derivative tus yam ntxwv los ntawm qhov kev txiav txim siab luv luv, yog li ntawd nws yog siv los ntawm cov neeg mob uas muaj ntshav qab zib hom 2 thiab muaj qhov yuav ua rau muaj ntshav qab zib tsawg.

Txais tos ntawm Glyurenorm los ntawm cov neeg mob uas mob ntshav qab zib hom 2 thiab mob siab ua ib txwm muaj kev nyab xeeb. Qhov tshwj xeeb tsuas yog ua kom qeeb qeeb tshaj ntawm kev siv tsis tau glycidone metabolism khoom hauv cov neeg mob ntawm cov qeb no. Tab sis nyob rau hauv cov neeg mob uas tsis muaj peev xwm ua rau hepatic, cov tshuaj no yog qhov tsis xav noj.

Kev ntsuam xyuas pom tau hais tias kev noj Glyurenorm rau ib thiab ib nrab thiab tsib xyoos tsis ua rau nce hauv lub cev hnyav, txawm tias qhov hnyav me me hauv lub cev hnyav tuaj yeem ua tau. Kev tshawb fawb sib piv ntawm Glurenorm nrog rau lwm cov tshuaj, uas yog neeg mob ntawm sulfonylureas, qhia txog qhov tsis muaj qhov hnyav pauv hauv cov neeg mob uas siv cov tshuaj no ntau dua ib xyoos.

Tsis muaj xov xwm qhia txog cov nyhuv ntawm Glurenorm ntawm lub peev xwm los tsav tsheb. Tab sis tus neeg mob yuav tsum tau ceeb toom txog cov tshwm sim muaj ntshav qab zib tsawg. Tag nrho cov kev tshwm sim no tuaj yeem tshwm sim thaum kho nrog cov tshuaj no. Ceev faj yuav tsum muaj thaum tsav tsheb.

Cev xeeb tub, pub niam mis

Tsis muaj cov ntaub ntawv qhia txog kev siv Glenrenorm los ntawm cov poj niam thaum lub cev xeeb tub thiab lactation.

Nws tsis paub meej tias glycidone thiab nws cov khoom lag luam metabolic nkag mus rau hauv niam mis. Cov poj niam cev xeeb tub uas muaj ntshav qab zib yuav tsum tau saib xyuas lawv cov ntshav qab zib kom ze.

Kev siv cov tshuaj tiv thaiv ntshav qab zib rau cov poj niam cev xeeb tub tsis tsim cov kev tswj hwm tsim nyog ntawm cov metabolism hauv cov metabolism. Vim li no, noj cov tshuaj no thaum cev xeeb tub thiab lactation yog contraindicated.

Yog tias cev xeeb tub tshwm sim lossis yog koj npaj ua lub sijhawm kho nrog tus neeg sawv cev no, koj yuav tsum tso Glyurenorm thiab hloov mus rau cov tshuaj insulin.

Yog tias mob raum

Txij li kev pom zoo ntawm Glyurenorm dhau los ntawm txoj hnyuv, hauv cov neeg mob uas lub raum tsis ua haujlwm, cov tshuaj no tsis txuam nrog. Yog li, nws tuaj yeem raug xa mus yam tsis muaj kev txwv rau cov neeg uas yuav muaj nephropathy.

Kwv yees li 5 feem pua ​​ntawm cov khoom lag luam metabolic ntawm cov tshuaj no tau tawm los ntawm ob lub raum.

Ib txoj kev tshawb nrhiav los sib piv cov neeg mob ntshav qab zib thiab raum ua rau ntau qib mob, nrog rau cov neeg mob kuj tau mob ntshav qab zib, tab sis tsis muaj qhov ua tsis tau mob lub raum, tau qhia tias kev siv tshuaj 50 mg ntawm cov tshuaj no muaj feem cuam tshuam zoo li cov piam thaj.

Tsis muaj qhov tshwm sim ntawm kev mob ntshav qab zib tau sau tseg. Los ntawm qhov no nws hais tias rau cov neeg mob uas tsis hnov ​​mob lub raum, kev hloov kho ntau dua yog tsis tsim nyog.

Alexey “Kuv mob tus mob ntshav qab zib hom 2, lawv muab tshuaj rau kuv dawb. Qee qhov lawv muab Glurenorm rau kuv hloov lwm cov tshuaj mob ntshav qab zib uas kuv tau txais ua ntej thiab uas tsis muaj nyob rau lub sijhawm no. Kuv tau siv nws rau ib lub hlis thiab tuaj txog tias nws yuav zoo dua los yuav cov tshuaj uas haum kuv rau nyiaj. Glurenorm tswj ntshav qabzib hauv lub cev tsis sib luag, tab sis nws tsim kev phiv heev, tshwj xeeb yog ziab hauv lub qhov ncauj thaum tsaus ntuj yog qhov mob heev kawg. "

Valentina “Tsib lub hlis dhau los, Kuv tau txheeb pom tus mob ntshav qab zib hom 2, tom qab txhua txoj kev kuaj xyuas, Glurenorm tau raug tshuaj. Cov tshuaj no zoo heev, cov ntshav qab zib hauv lub cev yuav luag zoo li qub (Kuv kuj ua raws li kev noj haus zoo), yog li kuv tuaj yeem pw tsaug zog ib txwm muaj thiab tau tawm hws ntau. Yog li ntawd, Kuv txaus siab rau Glurenorm. ”

Maninil Nta

Maninil yog cov tshuaj muaj ntshav qab zib uas nws muaj tshuaj yog glibenclamide. Hais txog PSM 2 tiam.

Muaj ob daim ntawv ntawm cov tshuaj:

• li ib txwm - 5 mg ntsiav tshuaj nrog lub bioavailability ntawm 70% thiab ib nrab-lub neej ntawm 10-12 teev,
• microionized - ntsiav tshuaj ntawm 3.5 thiab 1.75 mg, bioavailability ntawm li 100% thiab ib nrab-lub neej ntawm 3 teev.

Qhov kev txiav txim ntawm cov tshuaj yog tias lub pancreatic β-cov hlwb ua rau cov kua dej ntau lawm, ua rau cov ntshav qab zib tsawg dua.

Pib siv rau 24 teev, yog li nws tau kho 30 feeb ua ntej noj mov 1 zaug hauv ib hnub. Maninil yog nqus tau sai thiab yuav luag mus txog qhov kawg. Kev mob ntshav siab tshwm sim hauv cov qe ntshav. Nws yog tawm nrog rau cov kua tsib thiab tso zis. Maninil muaj cov nyhuv diuretic uas tsis muaj zog.

• ntshav qab zib hom 1
• hnyuv ob tog,
• decompensation metabolic (ketoacidosis, precoma, coma),
• mob siab thiab mob raum,
• piam thaj-6-phosphate dehydrogenase tsis txaus,
• cev xeeb tub thiab lactation
• tus neeg tsis kam txais.

Nrog ceev faj - nrog kub taub hau, mob cawv ntev, muaj cov kab mob qog, ua haujlwm ntxiv rau lub caj pas pituitary thiab adrenal cortex, hauv cov neeg muaj hnub nyoog tshaj 70 xyoo.

• xeev siab ntuav, ntuav, raws plab, pom tsis txaus, lub ntsej muag yog xim hlau hauv qhov ncauj, mob plab,
• txo qis hauv cov qe ntshav, ntshav dawb thiab qe ntshav liab, ntshav tsawg tsis txaus,
• urticaria, pruritus, petechiae, kev tsis haum tshuaj,
• kab mob siab, cholestasis, daj ntseg.

Nta ntawm Diabeton

Diabeton yog ib qho hypoglycemic tus neeg sawv cev, cov tshuaj nquag ntawm uas yog gliclazide.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj hauv qhov ntau npaum 80 thiab 60 mg. Nws hais txog PSM

Cov tshuaj nquag txo cov ntshav qab zib. Cov tshuaj muaj qhov zoo ntawm lub permeability ntawm phab ntsa ntawm cov hlab ntsha, txo qhov kev pheej hmoo ntawm thrombosis ntawm cov hlab ntsha me. Tsis nrog los ntawm kev hnyav nce, pab kom poob phaus. Nws cov thawj coj (nrog rau txoj cai ntau npaum) tsis ua rau cov mob ntshav qab zib.

Nws yog zoo nqus los ntawm lub plab zom mov, metabolized hauv daim siab thiab ua rau hauv cov zis.

Tsis kam thiab tus txheeb ze contraindications:

Teeb meem thiab phiv:

• cov txo hauv cov ntshav qabzib tsawg dua,
• lub siab ua ntxhov,
• angina pectoris
• nce hauv plawv dhia,
• nce ntshav siab.

Lub ntsiab tseem ceeb ntawm cov tshuaj yog qhov tsis txaus ntseeg metabolism. Cov metabolism no ua rau cov kev hloov tas mus li hauv theem ntawm glycemia. Thaum lub sijhawm sim, cov biochemists pom pom tias daws qhov teeb meem thiab tsim Diabeton MV. Nws txawv ntawm qhov dhau los dhau los ntawm kev du thiab qeeb tso tawm ntawm gliclazide. Yog li ntawd, cov piam thaj yuav tsum tau ceev cia rau hauv lub cev.

Glidiab Nta

Qhov no yog qhov tshuaj hypoglycemic. Muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 80 thiab 30 mg. Hais txog PSM pawg, yog qhov tshuaj tiv thaiv kab mob qhov ncauj ntawm 2 tiam. Cov tshuaj yeeb tshuaj yog gliclazide.

Qhov mob tseem ceeb rau kev noj cov tshuaj yog qhov ua haujlwm zoo β-hlwb ntawm cov txiav.

Nws ua rau kev tsim cov tshuaj insulin thiab nce qhov rhiab heev ntawm cov ntaub so ntswg peripheral rau nws. Normalizes vascular permeability, txo kev pheej hmoo ntawm cov ntshav txhaws hauv cov hlab ntsha. Tiv thaiv txoj kev loj hlob ntawm retinal pathology. Pab txo qhov hnyav hauv lub cev.

Yuav luag tag nrho nqus los ntawm cov hnyuv, mus txog qhov siab siab hauv 6-12 teev tom qab noj tshuaj. Nws yog metabolized hauv daim siab, tawm hauv cov quav thiab tso zis.

Cov tshuaj tiv thaiv zoo ib yam li Diabeton

Qhov tshwm sim: hypoglycemia, xeev siab, ntuav, daj ntseg, nce ntawm AcAT thiab AlAT nyob rau hauv kev kuaj ntshav, txo qis platelets thiab cov qe ntshav dawb, ua haujlwm ntshav thiab tsis haum. Muaj kev pheej hmoo ntxiv ntawm cov piam thaj poob hauv qab zib thaum noj cov tshuaj ethanol.

Txoj kev kho yog nqa tawm ua ke nrog kev noj zaub mov muaj calorie tsawg-carb. Ib qho kev ntsuas tas li ntawm kev yoo mov glycemia thiab tom qab noj mov yog qhov tsim nyog.

Glidiab MV yog tus cwj pwm los ntawm kev maj mam thiab kev thauj ntawm gliclazide rau hauv cov ntshav.Vim tias qhov no, cov nyhuv ntawm Glidiab tau khaws cia nyob rau hauv tib theem, uas ua rau kom cov tshuaj ntawm cov tshuaj zoo dua thiab zam tsis txhob mob ntshav qab zib.

Qhov twg yog qhov zoo dua thiab ua haujlwm

Ntxiv rau cov tshuaj saum toj no, muaj lwm tus: Glurenorm, Gluconorm, Amaril, Glucofage, Glyclazide. Xaiv qhov twg zoo dua, nws yog qhov yuav tsum tau soj ntsuam tus kheej ntawm tus yam ntxwv ntawm lub cev, kab mob thiab contraindications.

Ib qho tshuaj tiv thaiv kab mob nrog cov tshuaj nquag glycidone hauv ib qhov tshuaj ntawm 30 mg.

Hais txog PSM. Nws ua rau lub zog tsim tawm cov tshuaj insulin. Nws yuav luag txhua qhov los ntawm cov hnyuv zom zaub mov. Cov tshuaj txiav tawm hauv daim siab. Nws nyob hauv cov quav, quav thiab zis. Muaj ib qho tsis zoo - lawv pab txhawb tsim cov tshuaj insulin tsis hais txog qib piam thaj, i.e. ua ob qho tib si nrog cov piam thaj ib txwm thiab nrog hyperglycemia.

Qhov no yog cov tshuaj sib xyaw ua ke uas muaj glibenclamide thiab metformin.

Cov tshuaj no tsis cuam tshuam nrog txhua lwm yam. Metformin txhim kho cov nqaij mos ua kom lub cev zoo dua qub, ua kom cov roj cholesterol thiab txo qhov hnyav. Glibenclamide pab txhawb nqa cov piam thaj hauv cov leeg thiab nplooj siab. Muaj ib qho tsis txaus ntseeg - qhov no yog qhov txaus ntshai ntawm kev txo ntshav qab zib vim qhov txo qis hauv cov ntshav qab zib.

Cov tshuaj tseem ceeb yog glimepiride. Tus neeg zoo rau PSM pawg ntawm 3 tiam.

Hom tau txais txiaj ntsig - ß cov hlwb dhau los ua kom qeeb dua. Amaryl txo cov kev pheej hmoo ntawm thrombosis, txo cov roj (cholesterol). Nws tuaj yeem siv rau hauv cov neeg mob lub raum tsis ua haujlwm, vim tias qhov tseem ceeb yog nyob hauv cov quav.

Tsis zoo li PSM, nws tsis txhawb cov tshuaj insulin zais zis thiab tsis muaj cov nyhuv hypoglycemic.

Nws inhibits qhov tsim los ntawm cov piam thaj hauv lub siab. Ncua kev nqus ntawm cov carbohydrates hauv cov hnyuv. Nws muaj cov txiaj ntsig zoo ntawm lipid metabolism, txo cov roj (cholesterol).

Nws yog rau PSM 2 tiam ntawm cov tshuaj.

Nws muaj cov txiaj ntsig zoo ntawm kev sib xyaw ntawm cov ntshav, txo qhov kev pheej hmoo ntawm cov hlab ntsha me, thiab txo cov tshuaj insulin tsis kam. Ntawm qhov tsis sib xws: pab txhawb rau qhov hnyav, nrog rau siv ntev, kho cov nyhuv yog txo qis.

Cov kws kho mob xav

Anastasia Alexandrovna, endocrinologist, muaj 8 xyoo

Amaryl yog ib qho tshuaj zoo heev vim nws qhov kev ua haujlwm dual ntawm kev ua. Nws tswj ntshav qab zib. Qhov zoo tshaj plaws ntawm kev zais cia. Tsis tshua muaj nqi rau pawg tshuaj no. Muaj kev pheej hmoo siab ntawm hypoglycemia. Txhua tus neeg mob yuav tsum xaiv cov koob tshuaj ib tus zuj zus. Qhov zoo tshaj plaws muab coj los ua ke nrog metformin.

Elena Ivanovna, endocrinologist, muaj 32 xyoo

Maninil. Cov tshuaj sai tawm ntawm lub plab zom mov, yog li ua tiav cov nyhuv siab. Kuv sau cov tshuaj rau hauv kev kho mob ntawm hom 2 mob ntshav qab zib mellitus hauv kev sib xyaw nrog lwm cov tshuaj thiab kev noj cov ntshav qab zib. Kuv xaiv cov koob tshuaj ntawm cov tshuaj ib lub zuj zus kom tsis suav qhov kev phiv los ntawm cov tshuaj.

Ntshav Qab Zib Kev Ntsuam Xyuas

Catherine, 51 xyoo.

Kuv tau mob ntshav qab zib tau 12 xyoos, rau txhua lub sijhawm kuv hloov ntau tshaj kaum ob txoj tshuaj. Tam sim no kuv tsuas noj Amaryl ntsiav tshuaj. Metformin raug tso tseg vim tias tsis muaj ib qho coj ua. Qab zib, ntawm chav kawm, tsis ncav cuag qhov tseem ceeb, tab sis tsawg kawg muaj teeb meem.

Lub hli dhau los, Glyclazide MV tau muab hloov rau Diabeton. Thaum xub thawj kuv xav yuav lub tshuaj qub, tab sis ntawm kev pom zoo los ntawm kws kho mob Kuv txiav txim siab sim tshuaj tshiab. Kuv tsis xav tias qhov sib txawv, tab sis kuv txuag tau nyiaj. Cov tshuaj txo qis kuv cov piam thaj kom zoo thiab txhim kho kuv lub dag zog. Glycemia yog qhov tsawg kawg thiab ib txwm kuv ua txhaum. Thaum tsaus ntuj, qab zib tsis poob, tshwj xeeb yog kuaj xyuas.

Txhawm rau txiav txim siab seb cov neeg mob twg thiaj li xaj tshuaj Maninil, Diabeton, Glidiab lossis lwm yam tshuaj, tus kws kho mob yuav tsum. Qhov kev xaiv ntawm cov tshuaj rau kev kho mob ntawm hom 2 ntshav qab zib yog nqa tawm los ntawm kws kho mob nkaus xwb. Nws yog ua raws cov txiaj ntsig ntawm kev tshuaj ntsuam thiab muaj feem xyuam rau tus yam ntxwv ntawm tib neeg lub cev.

Txhua ntawm cov tshuaj no zoo heev, ua tau zoo txo ​​cov ntshav qabzib hauv cov ntshav.

Tus neeg mob nws tus kheej yuav tsum nco ntsoov txoj kev noj qab haus huv zoo. Hauv kev xyaum, nws tau pom tias ntau tus neeg mob, muab cov zaub mov noj kom tsawg thiab tawm dag zog lub cev, tawm tag nrho cov tshuaj hypoglycemic.

Kev kuaj xyuas neeg mob Glurenorm

Kuv yog hom 2 mob ntshav qab zib, txais tshuaj rau dawb. Glurenorm tau muab rau kuv ua qhov hloov pauv rau Diabeton, uas tsis muaj. Kuv coj ib lub hlis thiab txiav txim siab tias nws yog qhov zoo dua los yuav rau kuv cov nyiaj ntau dua li muaj kev txom nyem nrog nws. Tau, qab zib yog tswj qhov qub, tab sis cov kev mob tshwm sim los ntawm nws tau manifested hauv lawv tus kheej. Nws tau qhuav heev hauv nws lub qhov ncauj, tshwj xeeb tshaj yog thaum tsaus ntuj, yuav tsum khaws ib khob dej rau ntawm nws lub rooj noj mov, haus 2-3 zaug ib hmos. Digestive teeb meem pib, cem quav tau tsim txom, thiab txawm pib noj ib qho tsis zoo. Txog thaum kawg ntawm lub hlis, kuv lub siab poob tag. Txhua yam mus thaum nws hloov mus rau lwm cov tshuaj dua.

Rau lub hlis dhau los, Kuv tau kuaj mob ntshav qab zib mellitus, kuaj mob thiab kho tus mob glurenorm. Kuv tuaj yeem hais li cas? Nws pab, cov ntshav qab zib yuav luag zoo li qub (Kuv sim ua raws li kev noj zaub mov), Kuv pw tsaug zog zoo, tawm hws tau dhau los. Yog li kuv tsis yws txog cov kab mob glutenorm.

Kev faib tawm

Txij li thaum muaj ntau cov tshuaj los txo cov ntshav qab zib, Kuv txiav txim siab los qhia koj rau lawv ua ntej. Muaj cai nrog txhua tus neeg hauv tsab xov xwm no. Rau koj kom yooj yim, kuv yuav qhia hauv kab ntawv rau cov lag luam nrov tshaj plaws, tab sis nco ntsoov tias muaj ntau ntxiv. Yog li lawv nyob ntawm no:

1. Pab pawg neeg loj (uanuan) thiab nws tus sawv cev yog metformin (siofor).
2. Pab pawg neeg sulfonylurea thiab nws cov neeg sawv cev yog glibenclamide (maninyl), glyclazide (diabeton mv 30 thiab 60 mg), glimepiride (amaryl), glycidone (glurenorm), glipizide (minidiab).
3. Cov pab pawg hauv pawg thiab nws tus neeg sawv cev tsuas yog repaglinide (novonorm).
4. Cov thiazolidinedione pab pawg thiab nws cov sawv cev yog rosiglitazone (avandium) thiab pioglitazone (actos).
5. Cov pab pawg ntawm alpha-glucosidase inhibitors thiab nws tus sawv cev yog acarbose (glucobai).
6. Pab pawg ntawm dipeptidyl peptidase-4 inhibitors (DPP-4) thiab nws cov sawv cev yog vildagliptin (galvus), sitagliptin (Januvia), saxagliptin (onglise).
7. Cov pab pawg ntawm glucone-zoo li peptide-1 agonists (GLP-1) thiab nws cov neeg sawv cev yog exenatide (byeta), liraglutide (yeej).
8. Dab neeg Pawg ntawm cov tshuaj tiv thaiv ntawm sodium-glucose-cotransporter hom 2 inhibitors (SGLT2 inhibitors) - dapagliflozin (Forsig), canagliflozin (Invokana), empagliflosin (Jardians)

Ntau cov tshuaj hypoglycemic yog tsim, lawv txawv ntawm txhua lwm yam hauv lawv keeb kwm thiab tshuaj kua tshuaj. Xws li pawg ntawm qhov ncauj hypoglycemic tus neeg sawv cev yog qhov txawv:

• sulfonylurea derivatives,
• Cov chaw kho mob
• lojmuas
• thiazolidinediones,
• α-glucosidase inhibitors,
• incretins.

Tsis tas li ntawd, ib pawg tshiab ntawm cov tshuaj txo cov ntshav qab zib tau tsis ntev los no tau muab coj los ua ke - cov no yog cov neeg mob ntawm hom 2 sodium glucose cotransporter inhibitors (SGLT2).

Txhua yam ntawm cov tshuaj muaj qhov cuam tshuam rau ntau qhov sib xyaw ntawm cov tshuaj tiv thaiv thiab cov kev mob tshwm sim, nrog rau ntau yam tshuaj thiab cov nqi kho mob. Qhov no yog vim qhov tseeb tias lawv cov kev teem caij yuav tsum tau nqa tawm ntawm tus kws tshwj xeeb.

Txhua tus mob ntshav qab zib paub tias nws muaj ntau yam tshuaj qab zib rau cov ntshav qab zib hom 2. Cov ntawv sau tau dav heev, thiab cov tshuaj lawv tus kheej muab kev pab zoo rau cov neeg mob zoo li no.

Lawv tuaj yeem siv ob qho tib si rau kev kho mob monotherapy, uas yog, kev kho mob ntawm tus kabmob yog nqa nrog ib yam khoom, thiab rau kev sib koom ua ke, uas yog, ntau cov ntsiav tshuaj sib txawv tuaj yeem siv. Lawv txoj kev sib xyaw nrog insulin yog txawm ua tau.

Sulphonylureas

Lawv cov kev ua ntawm kev ua raws li kev txo qis glycogen concentration hauv lub siab ua haujlwm. Lwm cov nyhuv yog qhov kev tsim ntawm insulin ntau lawm vim qhov kev txum tim rov qab ntawm cov leeg hlwb. Cov neeg sawv cev uas nto moo tshaj plaws ntawm cov pab pawg no yog Diabeton, Amaril, Maninil. Feem ntau, lawv qhov kev nkag yuav tsim ib hnub ib zaug.

Ib chav kawm ntawm cov tshuaj uas tau pom ntev ntev. Txog rau tam sim no, feem ntau siv cov khoom xyaw nquag yog metformin, rau ntawm cov hauv paus uas npaj xws li Siofor, Glucofage thiab lwm tus tau ua.

Nws yog feem ntau ua ke nrog lwm cov tshuaj. Lawv tsuas yog siv lawv tsis tsuas yog nyob rau hom 2 mob ntshav qab zib, tab sis kuj tseem nyob rau lwm yam mob nrog glycemia ntau ntxiv, xws li kev mob metabolic syndrome lossis rog rog ntau.

Tshuaj kho mob ntshav qab zib

Muaj ntau cov tshuaj rau hom ntshav qab zib hom 2. Lawv tau muab faib ua pab pawg:

• Kev Loj Loj.
• Sulfonylurea npaj.
• Thiazolidinediones (glitazones).
• Qhuas cov neeg tswj hwm (glinids).
• Α-glucosidase inhibitors.
• Incretinomimetics.
• Dipeptidyl peptidase inhibitor - IV.

Feem ntau, kev kho mob ntshav qab zib hom 2 pib nrog tshuaj monotherapy. Qhov no feem ntau yog kev noj zaub mov noj lossis tshuaj lub teeb me me.

Cov hau kev kho mob ntxiv yuav raug txiav txim tsuas yog thaum cov pib qis tsis muab cov nyhuv tshuaj kom zoo. Qhov teeb meem tseem ceeb yog tias ib qho tshuaj feem ntau tsis tuaj yeem daws txhua yam teeb meem, yog li cov kws kho mob tau yuam kom coj los kho nrog ntau hom tshuaj.

Txawm li cas los xij, cov kws tshawb fawb niaj hnub muaj peev xwm txhim kho cov tshuaj uas tuaj yeem hloov ntau yam tshuaj kho tau zoo hauv ib zaug. Ua ke nrog cov tshuaj tiv thaiv hypoglycemic feem ntau muaj kev nyab xeeb dua li lawv cov kev sib koom tes, vim tias lawv tsis ua rau kev tsim cov kev mob tshwm sim.

Ib qho nrov tshaj plaws ntawm cov tshuaj sib tov yog suav tias yog "Glibomet." Nws yog tawm yog tias kev kho mob nrog cov tshuaj piav qhia saum toj no tsis tau tiav. Cov tshuaj no feem ntau tsis tau siv rau cov neeg mob ntshav qab zib hom 1, zoo rau cov menyuam yaus thiab cov neeg muaj lub raum thiab lub siab tsis ua haujlwm. Tsis tas li, cov tshuaj no tuaj yeem siv tsis tau thaum cev xeeb tub thiab lactation.

Nyob rau hauv tsis muaj mob tsis siv tshuaj rau tus kheej, tsis txhob kho cov tshuaj ntau thiab tsis hloov mus rau lwm cov tshuaj. Tso siab rau tus kws tshaj lij uas paub zoo thiab koj tus mob yuav zoo dua.

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Kev kho tshuaj insulin

Kev lag luam kws kho mob niaj hnub no muaj ntau yam tshuaj ntawm qab zib-rau qis. Tab sis cov kws tshaj lij koom siab hais tias yog tias muaj kev noj haus nruj thiab ntau kawg ntawm kev siv cov piam thaj kom txo qis cov tshuaj tsis coj qhov tshwm sim uas xav tau thiab glycemia tsis thim rov qab, nws yog qhov yuav tsum tau pib kho cov tshuaj insulin.

Ua ke nrog cov pab pawg tau hais los saum toj ntawm cov tshuaj tshiab no, insulins tso cai tswj tau txhua theem ntawm cov ntshav qab zib theem ntawm tus neeg mob uas muaj ntshav qab zib hom 2. Tsis txhob ua yam tsis muaj kev kho tshuaj insulin yog tias, vim li cas los xij, kev phais mob yog qhia rau tus mob ntshav qab zib.

Insulins Niaj hnub Ua yeeb yaj kiab luv luv (6-8 teev):

• Insuman Sai Sai,
• Humulin Tsis tu ncua,
• Actrapid NM.

Cov tshuaj insulin ultrasonic (3-4 teev):

Cov tshuaj tiv thaiv ntev (12-16 teev):

• Protafan NM,
• Humulin NPH,
• Insuman basal.

Insulins nkaus ua ke:

• Humulin MZ,
• Tsim Meej
• Mikstard NM,
• Insuman Comb.

Txoj kev kho kom tswj tau cov ntshav qab zib ib txwm xaiv tau rau txhua tus neeg mob, suav nrog kev pheej hmoo ntawm cov kev mob tshwm sim thiab lub cev xav txog cov tshuaj tshwj xeeb.

Thaum kuaj pom tus mob ntshav qab zib hom 2 sai, Metformin raug tshuaj. Yog tias nws tsis tuaj yeem ua tiav theem ntawm glycemia, cov tshuaj tshiab ntawm tib pab pawg los yog kev sib koom ua ke yuav tau xaiv.

Saib xyuas koj txoj kev noj qab haus huv!

Tshuaj tswj xyuas ntshav qab zib hom 2

Yog tias muaj suab thaj hauv cov ntshav thiab kev kuaj mob tsis txaus siab tau ua - ntshav qab zib, thawj qhov uas xav ua yog hloov pauv koj txoj kev ua neej. Nws yuav xav tau kev pab cuam kom txo qhov hnyav, ua kom lub cev.

Tsuas yog txoj hauv kev no tuaj yeem ua tiav cov txiaj ntsig zoo ntawm kev kho mob. Tab sis lub hom phiaj tseem ceeb yog kom txo qis qab zib hauv lub cev rau lub sijhawm ntev, thiab tseem tsim nyog siv rau cov tshuaj.

Ib txwm, tsis muaj ib qho kev pabcuam khomob dav dav; txhua tus neeg mob lub cev yog tus neeg.

Cov kws tshaj lij hais tias thawj qhov tus kws tshaj lij uas kuaj mob ntshav qab zib yuav tsum tau ua yog coj tshuaj Metformin rau tus neeg mob. Nov yog thawj theem ntawm kev kho tshuaj (Yog tias tsis muaj contraindications). Cov tshuaj yuav muaj txiaj ntsig zoo rau cov piam thaj, pab kom poob phaus, thiab tseem muaj cov npe me ntawm cov kev mob tshwm sim (qhov tseem ceeb!) Thiab tus nqi qis.

Txhaj Tshuaj Kho Mob

Hom 2 mob ntshav qab zib mellitus feem ntau muaj teeb meem nrog kev kho kom haum ntawm cov kua qab zib tom qab. Hauv qhov xwm txheej no, tshuaj ntau ntxiv txo cov ntshav qab zib tom qab noj mov yam tsis ua rau kom mob ntshav qab zib.

Cov tshuaj muaj zog ntxiv yog hom tshiab ntawm txoj kev kho rau kev kho mob hom 2 mob ntshav qab zib mellitus - lawv tau pom zoo thawj zaug siv hauv Tebchaws Asmeskas xyoo 2005. Nyob rau hauv 2014, tshwm sim nyob rau hauv Russia thiab Ukraine.

Qee zaum DPP-4 cov tshuaj tiv thaiv tsis raug yuam kev hu ua cov tshuaj muaj zog ntxiv, tab sis DPP-4 cov tshuaj tiv thaiv nyob rau hauv chav kawm ntawm cov tshuaj hu ua gliptynami.

Cia peb xav txog nyob rau hauv ntau dua kom meej lub ntsiab lus thiab zoo ntawm incretin npaj.

Incretin tshuaj siv rau hauv kev kho mob ntshav qab zib hom 2, thaum kev noj haus thiab kev tawm dag zog, thiab lwm yam tshuaj muaj suab thaj tsis ua rau xav kom ua haujlwm. Lawv feem ntau yog siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob - metformin thiab thiazolidinedione.

Cov tshuaj Incretin yog siv ua ke nrog cov tshuaj insulin luv thiab nruab nrab. Cov no yog cov tshuaj rau txhaj tshuaj subcutaneous, txawm li cas los xij, lawv tsis yog cov tshuaj insulin.

Cov piam thaj rau cov yeeb yaj kiab tshiab-txo cov tshuaj hormones yog dab tsi

Cov kev npaj rau tam sim no ntawm kev lag luam hauv tsev yog kev pom zoo los ntawm EU lub teb chaws.

Metformin siv feem ntau kho mob ntshav qab zib. Lub sijhawm no, qhov no yog "tus txheej txheem kub" rau kev kho "kab mob qab zib". Kaum ob ntawm cov kev tshawb fawb thoob ntiaj teb tau ua tiav uas tau ntseeg tau pom tias muaj txiaj ntsig zoo ntawm kev siv tshuaj.

Nws lub ntsiab zoo piv rau lwm yam tshuaj yog:

1. Tshaj tawm cov nyhuv hypoglycemic. Vim tias qhov txo qis hauv kev tsis kam ntawm cov ntaub so ntswg mus rau insulin, cov tshuaj tso cai rau cov kua nplaum los ntawm lub hlwb ib txwm, uas txo nws cov concentration hauv cov ntshav.
2. Tsawg tsawg tus los ntawm cov nyom tsis haum. Txawm li cas los xij, ib qho tsis tuaj yeem tham txog lawv qhov qhaj tag.
3. Zoo mob siab ntev.
4. Yooj yim thiab cov tswv yim hauv cov ntawv thov.

Cov tshuaj muaj nyob hauv 500 mg ntsiav tshuaj. Qhov kev siv tshuaj txhua hnub yog 1000 mg hauv 2 faib koob tshuaj tom qab noj mov. Nws yog ib qho tseem ceeb rau haus cov khoom nrog yam tsawg 200 ml dej.

Daim ntawv teev cov tshuaj siv rau "kev muaj qab zib noj qab haus huv" yog qhov tseeb ntev dua, tab sis cov kws tshawb fawb tseem niaj hnub tshawb nrhiav cov txheej txheem tshuaj tshiab tshiab.

Ib qho piv txwv yog cov tshuaj txo suab thaj rau cov ntshav qab zib hom 2:

1. Agonists ntawm glucagon-zoo li peptide-1 (GLP-1). Liraglutide feem ntau cuam tshuam cov rog metabolism thiab txo qhov hnyav ntawm tus neeg mob. Yog li, nws muaj peev xwm nce qhov rhiab heev ntawm cov ntaub so ntswg mus rau insulin. Nyob rau theem no, nws tsis suav nrog hauv kev kho mob tus qauv tam sim no, tab sis tau txais koob meej sai raws li ib qho kev ntxiv rau cov kev kho mob ib txwm muaj. Nws raug qhia zoo li pancreatic hormone siv tus cwj mem uas tshwj xeeb. Thawj cov tshuaj ntawm cov tshuaj yog 0.6 mg rau ib hnub nrog rau thawj zaug tshuaj subcutaneous. Ntxiv mus raws li kws kho mob cov lus qhia.
2. Cov tshuaj tiv thaiv ntawm dipeptidyl peptidase-4 (DPP-4). Sitagliptin nce tus naj npawb ntawm cov khoom sib txuam ntau ntxiv, uas ua kom cov haujlwm ntawm B-hlwb nrog kev nce ntxiv hauv cov khoom cua hauv lawv tus kheej lawm. Vim qhov no, glycemia txo qis. Muaj nyob rau hauv cov ntsiav tshuaj ntawm 25-50 mg. Tus Nqe Niaj Hnub - 100 mg nyob rau hauv 2 faib koob tshuaj, tsis hais noj zaub mov noj.

Raws li koj tuaj yeem pom, tus naj npawb ntawm cov tshuaj zoo rau hom ntshav qab zib 2 yog qhov loj heev.Qhov loj tshaj plaws yog kom tsis txhob ntxhov siab thiab ua raws txhua cov lus qhia ntawm tus kws kho mob tuaj koom. Nrog txoj kev xaiv zoo ntawm cov tshuaj, nws muaj peev xwm ua tiav kom tswj tau theem ntawm cov piam thaj hauv cov ntshav thiab muab lub neej zoo.

Nws yuav tsum raug sau tseg tias hom mob ntshav qab zib hom 2 yog qhov nyuaj los tswj cov pathology. Qhov no yog qhov tseeb tshwj xeeb tshaj rau cov neeg mob uas tsis ua raws li cov lus pom zoo los ntawm cov kws kho mob koom nrog txog lawv lub neej.

Kev tsim kho cov tshuaj tshiab tso cai rau koj los tswj tus kab mob no thiab pab tiv thaiv kev txhim kho ntawm nws cov teeb meem. Cov txiaj ntsig ntawm kev tiv thaiv pancreatic kuj tseem sau tseg, uas yog, nws sai sai tsis tshwm sim, uas tau pom nrog lub sijhawm ntev siv feem ntau ntawm cov tshuaj thib ob.

Ib qho ntawm cov qauv tseem ceeb thaum pib kho mob ntshav qab zib hom 2 yog qhov tsawg kawg pib tshuaj. Sij hawm dhau los, nrog qhov tsis txaus ntawm glycemia, cov kws kho mob koom nrog qhov tshuaj ntxiv, tsis muaj cov kev mob tshwm sim. Nws raug nquahu kom muab cov tshuaj los ua nrog kev noj zaub mov kom muaj tsawg thiab ua kom ib ce muaj zog.

Cov tshuaj insulin yog cov tshuaj tseem ceeb uas cov neeg muaj ntshav qab zib xav tau. Tab sis dua li nws muaj ntau cov tshuaj ntxiv rau kev tswj hwm qhov ncauj uas muaj cov nyhuv hypoglycemic. Lawv tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab noj ntawm qhov ncauj rau kev kho mob ntshav qab zib hom 2.

Cov tshuaj pab ua kom cov ntshav qab zib nyob li qub. Muaj ntau ntau pab pawg ntawm cov tshuaj. Cov no suav nrog sulfonylureas, meglitinides, biguanides, alpha-glucosidase inhibitors.

Rau cov tswj hwm kev tswj hwm, siv cov tshuaj insulin. Kev txhaj tshuaj yog qhov tseem ceeb heev rau cov neeg mob uas muaj ntshav qab zib hom 1. Qhov theem ntawm pathology no yog nrog los ntawm kev ua txhaum ntawm kev tsim cov tshuaj insulin endogenous. Yog li, txhawm rau ua kom tus neeg mob tus mob kom zoo, kev hloov kho hloov kho yuav tsum tau los ntawm kev qhia ntawm cov tshuaj insulin.

Cov kws kho mob feem ntau nyiam muab cov tshuaj hauv lub qhov ncauj hu ua "Glidiab" rau cov neeg mob. Lawv cov khoom xyaw nquag yog gliclazide. Cov tshuaj ua rau pom tseeb ntawm kev txo cov ntshav qab zib, txhim kho hematological tsis txaus, cov khoom hauv cov ntshav, hemostasis, cov ntshav ncig.

Lub cuab yeej tiv thaiv kev rov ua kom puas tsuaj, tshem tawm qhov tsis zoo ntawm platelets, muaj kev ua kom lub zog tsis zoo. Koj tsis tuaj yeem sau ntawv rau nws yog tias muaj qhov tsis txaus siab rau qhov tshuaj, hom 1 mob ntshav qab zib mellitus, ketoacidosis, tsis nco qab, raum thiab mob siab, ua haujlwm rau menyuam yaus thiab pub mis, hnub nyoog qis dua 18 xyoo.

Glimepiride

Cov ntsiav tshuaj rau lub qhov ncauj tswj hwm kev tsim tawm ntawm cov tshuaj insulin los ntawm tus txiav, txhim kho qhov tso tawm ntawm cov tshuaj no. Kuj zoo rau cuam tshuam kev txhim kho qhov rhiab ntawm peripheral cov ntaub so ntswg rau insulin. Cov tshuaj tau tawm rau hom 2 mob ntshav qab zib mellitus thaum kho mob ntshav siab los yog ua ke nrog metformin lossis insulin.

Nws tsis raug tso cai kom noj cov ntsiav tshuaj rau cov neeg muaj ketoacidosis, coma, siab rhiab heev rau cov tshuaj, mob siab mob siab lossis mob raum, lactose tsis haum, tsis muaj lactase hauv lub cev. Tsis tas li, koj tuaj yeem siv tsis tau cov tshuaj rau cev xeeb tub thiab lactating poj niam, menyuam yaus.

Levothyroxine Sodium

Muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj ntawm qhov ncauj hu ua “L-thyroxine”. Tso cai txhawm rau txhawm rau txhim kho cov txheej txheem kev zom zaub mov ntawm carbohydrates thiab lwm yam khoom tseem ceeb, ntxiv dag zog rau kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha, cov hlab ntsha hlwb.

Txhawm rau kom tshem tawm cov ntshav qab zib thiab nws cov tsos mob, cov tshuaj tshwj xeeb tau siv uas tau txhawm rau txhawm rau txo qis qis cov piam thaj hauv cov ntshav ntawm tus neeg mob. Cov kab mob antidiabetic (hypoglycemic) yuav yog rau kev siv niam txiv, nrog rau lub qhov ncauj.

Cov tshuaj hypoglycemic qhov ncauj hypoglycemic feem ntau tau faib raws li nram no:

1. sulfonylurea derivatives (cov no yog Glibenclamide, Glikvidon, Gliklazid, Glimepirid, Glipizid, Chlorpropamide),
2. alpha glucosidase inhibitors ("Acarbose", "Miglitol"),
3. meglitinides (Qeb Pawg, Pab Tshuaj Tiv Thaiv Me Nyuam),
4. kho mob loj ("Metformin", "Buformin", "Fenformin"),
5. thiazolidinediones (Pioglitazone, Rosiglitazon, Tsiglitazon, Englitazon, Troglitazon),
6. ncetinomimetics.

Cov yam ntxwv thiab kev ua ntawm sulfonylurea derivatives

Cov peev xwm ntawm sulfonylureas tau pom los ntawm kev sib tsoo heev nyob rau hauv nruab nrab ntawm lub xyoo pua xeem. Lub peev xwm ntawm cov tebchaw tau tsim nyob rau lub sijhawm thaum nws muab tawm tias cov neeg mob uas tau siv tshuaj sulfa kom tshem tawm cov mob sib kis tseem tau txais txo qis hauv lawv cov piam thaj hauv ntshav.

Yog li, cov tshuaj yeeb dej caw no tseem muaj lub suab hypoglycemic zoo rau cov neeg mob.

Vim li no, tam sim ntawd pib tshawb nrhiav sulfanilamide derivatives nrog lub peev xwm los txo qis theem ntawm cov piam thaj hauv lub cev. Txoj haujlwm no tau ua rau muaj kev sib txuas ntawm lub ntiaj teb thawj sulfonylurea derivatives, uas muaj peev xwm ua tau zoo los daws cov teeb meem ntshav qab zib.

Qhov cuam tshuam ntawm sulfonylurea derivatives yog txuam nrog kev ua kom tshwj xeeb pancreatic beta hlwb, uas cuam tshuam nrog kev tsim kho thiab nce ntau ntxiv ntawm cov tshuaj insulin endogenous. Qhov yuav tsum tau ua ua ntej kom muaj txiaj ntsig zoo yog qhov muaj nyob hauv lub txiav caj dab ntawm kev nyob thiab tag nrho beta hlwb.

Nws yog qhov tsim nyog tias nrog kev siv lub sijhawm ntev ntawm sulfonylurea derivatives, lawv cov txiaj ntsig zoo kawg yog ploj tag nrho. Cov tshuaj tsis haum rau kev cuam tshuam rau cov tshuaj insulin.

Cov kws tshawb fawb ntseeg tias qhov no yog vim qhov tsawg ntawm cov neeg tau txais ntawm beta hlwb. Nws kuj tau tshaj tawm tias tom qab so ib zaug hauv kev kho mob, qhov tshuaj tiv thaiv ntawm cov hlwb no rau cov tshuaj tuaj yeem kho kom rov qab zoo.

Qee qhov sulfonylureas tseem yuav muab cov nyhuv ua kom zoo li qub-ntxiv. Xws li qhov kev nqis tes ua tsis muaj qhov tseem ceeb hauv tsev kho mob. Cov teebmeem ntxiv-pancreatic muaj xws li:

1. kev nce hauv qhov txaus ntshai ntawm cov insulin-tiv thaiv cov nqaij ua rau insulin ntawm qhov kev ua tsis zoo,
2. ua rau lub siab ua cov ntshav qabzib ntau lawm.

Lub tswv yim tag nrho ntawm kev nthuav dav ntawm cov kev cuam tshuam ntawm lub cev yog vim qhov tseeb tias cov tshuaj ("Glimepiride" hauv kev tshwj xeeb):

1. nce tus naj npawb ntawm receptors uas rhiab rau cov tshuaj insulin nyob rau hauv lub hom phiaj cell,
2. tau zoo txhim kho kev sib cuam tshuam insulin-receptor,
3. normalize kev xa ntawm postreceptor teeb liab.

Tsis tas li ntawd, muaj pov thawj pom tias sulfonylurea derivatives tuaj yeem dhau los ua kev cuam tshuam rau kev tso tawm ntawm somatostatin, uas yuav ua rau nws muaj peev xwm txhawm rau txhim kho glucagon.

Sulfonylureas

Muaj ntau ntau tiam neeg ntawm cov khoom no:

• Lub Cim Thib 1: “Tolazamide”, “Tolbutamide”, “Carbutamide”, “Acetohexamide”, “Chlorpropamide”,
• 2nd tiam: Glibenclamide, Glikvidon, Glisoksid, Glibornuril, Gliklazid, Glipizid,
• Lub Cim Thib 3: Glimepiride.

Txog hnub, hauv peb lub tebchaws, cov tshuaj ntawm 1st tiam yuav luag tsis siv rau hauv kev coj ua.

Lub ntsiab sib txawv ntawm cov tshuaj 1 thiab 2 tiam nyob rau hauv sib txawv qib ntawm lawv cov kev ua ub no. 2nd tiam sulfonylurea tuaj yeem siv rau hauv cov tshuaj noj kom qis, uas pab ua kom zoo tsim nyog txo qhov muaj peev xwm ntawm ntau cov kev mob tshwm sim.

Hais lus nyob hauv lej, lawv qhov haujlwm yuav yog 50 lossis tseem 100 zaus dua. Yog li, yog tias qhov xav tau qhov nruab nrab yuav tsum tau noj ntau npaum li cas ntawm 1 tiam tshuaj yuav tsum yog los ntawm 0.75 txog 2 g, ces koob thib 2 tiam twb muab ib koob tshuaj 0.02-0.012 g.

Qee qhov hypoglycemic derivatives kuj tseem yuav sib txawv hauv kev thev taus.

Cov tshuaj uas nrov tshaj plaws

"Gliclazide" yog ib qho ntawm cov tshuaj uas tau sau tseg feem ntau. Cov tshuaj tsis yog tsuas yog ua tau zoo ntawm hypoglycemic nyhuv, tab sis kuj tseem muaj txiaj ntsig zoo rau kev txhim kho:

• hematological cov ntsuas
• rheological zog ntawm cov ntshav,
• tshuab ua dej khov kho, microcirculation ntawm cov ntshav,
• kev ua heparin thiab fibrinolytic,
• heparin tso taus.

Ntxiv rau, Glyclazide muaj peev xwm tiv thaiv kev txhim kho ntawm microvasculitis (kev mob puas tsuaj), tiv thaiv txhua yam kev txhoj puab heev ntawm platelets, ua rau muaj kev sib cais ntau thiab ua rau pom cov yam ntxwv ntawm cov antioxidant zoo.

Kev siv cov piam thaj hauv hom 2 mob ntshav qab zib mellitus

Txog rau hnub no, cov kws tshawb fawb tau tsim kho ntau yam tshuaj uas siv los kho ntshav qab zib. Feem ntau ntawm lawv muaj peev xwm ua tau zoo ntawm kev kho mob pathology.

Ib qho ntawm cov tshuaj nrov tshaj plaws thiab muaj txiaj ntsig zoo yog Glucophage rau hom ntshav qab zib hom 2. Nws cov khoom ua kom nquag plias yog metformin, cuam tshuam nrog biguanides.

Feem ntau cov tshuaj no yog sau los ntawm tus kws kho mob koom - tsev neeg, kws kho mob lossis endocrinologist. Nws yog tsim rau kev siv tas mus li thiab siv sijhawm ntev, muab rau nws tsis muaj cov kev tawm suab thiab kev pom zoo txaus los ntawm nws lub cev.

Ua tsaug rau Glucofage, kev tswj hwm tus kab mob zoo tau tiav. Hauv qee qhov tsis tshua muaj tshwm sim, kws kho mob tuaj yeem sau tshuaj kho lub sijhawm luv.

Mob ntshav qab zib siv

Endocrinologist, suav hais tias yog tus kws kho mob ntshav qab zib, paub meej tias kev ua haujlwm siab ntawm kev siv Glucofage, raws li cov ntaub ntawv los ntawm kev tshawb fawb ntau thiab ntawm lawv tus kheej hauv kev kho mob. Nws tso cai rau koj kom txo qis glycemia thiab glycated hemoglobin.

Qhov ntsuas ntawm lub neej zoo thiab kev soj ntsuam hais txog nws lub sijhawm yog kev txhim kho, txij li cov tshuaj tso cai rau kev tiv thaiv tsis ncaj ntawm kev txhim kho cov kab mob ntawm lub hom phiaj ntawm cov kabmob ntshav qab zib mellitus, xws li atherosclerosis, raum, qhov muag thiab lwm yam kab mob. Lwm qhov txiaj ntsig zoo yuav yog qhov txo qis hauv lub cev qhov hnyav. Feem ntau nws yog hom thib ob ntawm pathology uas yuav tsum tau muaj sijhawm ntawm Glucofage.

Kev Sib Sau thiab daim ntawv ntawm tso tawm

Glucophage muaj nyob rau hauv daim ntawv ntawm dawb coated ntsiav tshuaj npaj rau kev siv sab hauv. Nws muaj peb qhov tshuaj ntawm cov tshuaj nquag: 500 mg, 850 mg, 1000 mg. Nws yuav tsum tau yug los hauv lub siab tias feem ntau qhov tshuaj feem ntau tau faib tshwj xeeb los ntawm cov tshuaj noj. Koj yuav tsum tsis txhob coj nws los ntawm koj tus kheej kev txiav txim siab.

Glucofage yog tsim los ntawm Fabkis lub tuam txhab MerckSante. Txawm li cas los xij, muaj ntau ntau ntawm analogues, uas suav nrog:

• Siofor
• Metformin
• Diaformin,
• Metfogamma thiab lwm tus.

Cov tshuaj sib xyaw nrog cov tshuaj suav nrog metformin (cov khoom ua haujlwm tseem ceeb), povidone, magnesium stearate (uas yog cov tshuaj pab). Cov sib xyaw ua ke ntawm cov npog vov muaj suav nrog macrogol, hypromelase.

Tseem muaj kev sib xyaw ua ke ntawm Glucofage, thaum, ntxiv rau metformin, cov ntsiav tshuaj muaj lwm yam tshuaj rau kev kho mob ntshav qab zib - Douglimax, Dianorm-m thiab lwm tus.

Cov nyhuv ntawm cov tshuaj thiab qhia tau

Glucophage nyob rau hauv hom ntshav qab zib hom 2, nrog rau cov kev mob metabolic, tuaj yeem txo cov ntshav glycemia thoob plaws ib hnub los ntawm kev nce siab ntawm cov hlwb thiab cov nqaij mos lub cev mus rau endogenous (kev ua haujlwm rau sab hauv) thiab exogenous (siv tshuaj sab nraud) insulin.

Qhov no tsuas yog qhia txog kev siv Glucophage hauv hom mob ntshav qab zib hom thib ob, uas suav cov ntshav qab zib muaj feem cuam insulin. Cov tshuaj tsis cuam tshuam rau kev tsim cov tshuaj insulin hauv cov qe hlwb ntawm cov txiav. Ntxiv rau cov ntshav qab zib nws tus kheej, Glucophage yog ib feem ntawm cov txheej txheem rau kev kho mob siab rog, ua mob metabolic syndrome, thiab carbohydrate kam rau ua kev cuam tshuam.

Cov lus qhia luv luv

Glurenorm yog tshuaj hypoglycemic uas yog ib qho kev tso tawm ntawm sulfonylurea. Cov ntshav qab zib uas tsis yog-insulin-hom mob ntshav qab zib mellitus (hom 2 mob ntshav qab zib mellitus) yog ib qho teeb meem tseem ceeb tshaj plaws ntawm cov tshuaj niaj hnub vim muaj qhov xwm txheej loj thiab muaj kev pheej hmoo loj ntawm kev tsim cov mob macro- thiab cov teeb meem microvascular. Tseeb, txawm tias ib qho tseem ceeb dhia hauv kev yoo cov ntshav cov ntshav qab zib ntau ntau ua rau muaj kev pheej hmoo ntawm kev mob ntshav qab zib retinopathy, mob stroke thiab lub plawv nres. Cov txiaj ntsig ntawm ntau xyoo ntawm kev ceev faj ntawm cov kws tshawb fawb hauv cov koom haum tshawb fawb thiab cov chaw kho mob yog qhov rov qab kho lub tswv yim ntawm kev kho hom 2 mob ntshav qab zib mellitus: yog tias yav tas los lawv tau nrhiav los txo cov qib ntawm glycated hemoglobin rau qhov muaj nuj nqis (6.5-7%), tam sim no lawv mus rau kev kho mob ib leeg zuj zus, lawv tsis txiav txhua tus ib zuag. Raws li kev pom zoo txaus siab los ntawm cov kws tshaj lij tswv yim ntawm Lavxias endocrinologist, cov lus qhia rau kev txo qis glycated hemoglobin tau txiav txim siab raws li kev pheej hmoo ntawm kev mob ntshav qab zib, tus neeg mob lub hnub nyoog thiab qhov muaj cov teeb meem loj. Lub tswv yim no pab txo txoj kev pheej hmoo ntawm hypoglycemia thiab nws muaj feem cuam rau kev ua haujlwm ntawm cov hlab plawv.

Sulfonylurea kev npaj yog cov pab ntev uas tau siv tshuaj uas lawv lub peev xwm paub tau zoo rau cov kws kho mob endocrinologist. Lawv lub tswv yim tseem ceeb ntawm kev txiav txim siab yog qhov thaiv ntawm cov poov tshuaj raws nyob rau hauv cov qog ua ke ntawm beta hlwb ntawm cov txiav, uas cia li koom nrog kev koom tes ntawm calcium ions hauv lub cell thiab rhuav tshem cov secretory granules ntawm inulin cia, uas, nyeg, tso tawm rau hauv qhov chaw sib cais thiab pib "tsav" "ntxiv" piam thaj nyob rau hauv qhov chaw ntawm nws siv - ua ntej txhua yam, hauv cov leeg ntawm cov leeg thiab adipose nqaij thiab nplooj siab.

Xyoo tsis ntev los no, cov nomenclature ntawm hypoglycemic cov neeg sawv cev siv nyob rau hauv kev xyaum endocrinological tau hloov kho ntau dua, txawm li cas los xij, ib qho kev pom zoo ntawm txhua qhov kev kho mob tau muab los ntawm sulfonylureas. Ntawm lawv cov txiaj ntsig sawv ntsug kom paub meej cov hauj lwm zoo hauv kev txiav tseg hyperglycemia thiab tus nqi qis. Qhov ntxeev ntawm lub npib yog qhov ntxim nyiam ntawm kev txhim kho tsis nco qab qhov ua kom tsis haum tshuaj, uas, txawm li cas los xij, yuav txawv rau cov tshuaj sib txawv hauv cov pawg no. Kev mob ntshav qab zib nce ntxiv nrog ncua sijhawm hauv lub sijhawm thiab ib lub ncov ntshiab hauv kev txiav txim ntawm cov tshuaj, nrog cov tsos ntawm lub cev ua kom lub cev muaj zog, muaj kev cuam tshuam ntau ntxiv rau cov ntshav plasma protein thiab beta-cell receptors. Raws li qee qhov kev kwv yees, cov tshuaj yeeb yaj kiab tshaj plaws hauv qhov no yog glibenclamide, thiab glurenorm, ntawm qhov tsis sib haum, tsis tshua muaj kev phom sij vim lub sijhawm luv luv ntawm kev nqis tes ua. Ntxiv mus, nws cov hauj lwm zoo yog sib piv nrog lwm cov neeg sawv cev ntawm cov tshuaj ntawm pawg no. Cov txiaj ntsig pharmacological ntawm cov tshuaj tshwm sim tom qab 1-1.5 teev tom qab nws tswj hwm, qhov siab tshaj plaws pom tau tom qab 2-3 teev, tag nrho lub sijhawm ua haujlwm yog tag nrho ntawm 8-10 teev. Tus mob Glurenorm tuaj yeem siv rau hauv cov neeg muaj lub raum pathologies, suav nrog kev mob raum tsis ua haujlwm hauv thawj theem. Raws li kev tshawb nrhiav hauv chav haujlwm hauv tebchaws Lavxias, kev kho mob rau lub hlis nrog rau kev kho mob glurenorm coj tsis tau tsuas yog ua kom muaj kev txhim kho hauv cov ntshav qabzib metabolism, tab sis tseem ua rau lub raum ua haujlwm. Qhov kev ua tau zoo ntawm cov tshuaj hauv cov neeg muaj kev tiv thaiv kab mob siab tau pom zoo (nws ntseeg tau hais tias glurenorm muaj txiaj ntsig zoo ntawm hepatocytes).

Daim ntawv tso tawm

Cov ntsiav tshuaj yog dawb, du, puag ncig, nrog cov ntug beveled, nrog kev pheej hmoo ntawm ib sab thiab sau nrog "57C" ntawm ob sab ntawm kev pheej hmoo, lub tuam txhab logo tau kos rau sab tod.

Cov neeg siv: lactose monohydrate - 134.6 mg, hmoov nplej pob kws qhuav - 70 mg, hmoov nplej pob kws hmoov nplej - 5 mg, magnesium stearate - 0.4 mg.

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.
10 Pcs - hlwv (6) - pob khoom los ntawm cardboard.
10 Pcs - hlwv (12) - pob khoom los ntawm cardboard.

Cov tshuaj yog muab ntawm qhov ncauj. Nws yog ib qho tsim nyog yuav tsum ua raws li tus kws kho mob pom zoo txog kev noj tshuaj thiab noj haus. Koj yuav tsum tsis txhob tsum tsis noj cov tshuaj yam tsis tau sab laj nrog kws kho mob.

Thawj koob tshuaj Glyurenorm feem ntau yog 1/2 tab.(15 mg) thaum noj tshais. Cov tshuaj yuav tsum tau noj thaum pib noj mov. Tom qab noj Glyurenorm, zaub mov yuav tsum tsis txhob hla.

Yog tias noj 1/2 tab. (15 mg) tsis ua rau kev txhim kho kom txaus, tom qab sab laj nrog kws kho mob, qhov tshuaj yuav tsum maj mam nce ntxiv. Yog tias qhov koob tshuaj Glyurenorm txhua hnub tsis tshaj 2 tab. (60 mg), nws tuaj yeem raug muab rau hauv 1 koob tshuaj, thaum noj tshais.

Thaum muab tshuaj ntau dua, cov txiaj ntsig zoo tshaj plaws tuaj yeem ua tiav tau los ntawm kev noj tshuaj txhua hnub muab faib ua 2-3 koob. Hauv qhov no, qhov ntau tshaj yuav tsum tau noj thaum noj tshais. Nce hauv ib koob ntau dua 4 tab. (120 mg) / hnub feem ntau tsis ua rau muaj kev nce ntxiv hauv qhov ua tau zoo.

Qhov siab tshaj plaws niaj hnub noj yog 4 ntsiav tshuaj. (120 mg).

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kwv yees li 5% ntawm cov tshuaj metabolites yog ua rau lub raum. Hauv cov neeg mob uas lub raum tsis ua hauj lwm, tsis tas yuav hloov kho dua.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Kev noj ib koob tshuaj tshaj 75 mg rau hauv cov neeg mob uas lub siab tsis zoo ua haujlwm yuav tsum ua tib zoo saib xyuas tus neeg mob lub sijhawm. Cov tshuaj yuav tsum tsis txhob raug txwv rau cov neeg mob uas muaj lub siab tsis ua haujlwm hnyav, vim tias 95% ntawm qhov koob tshuaj yog metabolized hauv daim siab thiab tawm hauv cov hnyuv.

Nrog cov tshuaj tsis txaus ua haujlwm ntawm kev kho mob monotherapy nrog kev siv tshuaj Glyurenorm ®, tsuas yog kev teem caij ntxiv ntawm metformin tuaj yeem pom zoo.

Kev sib txuam

Nws muaj peev xwm nce cov nyhuv hypoglycemic nrog rau kev tswj hwm tib lub sijhawm ntawm glycidone thiab ACE inhibitors, allopurinol, analgesics thiab NSAIDs, antifungal tshuaj, chloramphenicol, clarithromycin, clofibrate, coumarin derivatives, fluoroquinolones, heparin, antioxidants, sulfonyl cyclamide, cyclamide cyclides , insulin thiab kab mob hauv lub qhov ncauj hypoglycemic.

Beta-blockers, sympatholytics (suav nrog clonidine), reserpine thiab guanethidine tuaj yeem txhim kho cov nyhuv hypoglycemic thiab tib lub sijhawm npog cov tsos mob ntawm hypoglycemia.

Nws yog ua tau kom txo cov nyhuv ntshav qab zib thaum kho mob glycidone thiab aminoglutethimide, sympathomimetics, glucagon, cov thyroid hormones, glucagon, thiazide thiab loopback diuretics, tshuaj tiv thaiv qhov ncauj, diazoxide, phenothiazine thiab tshuaj muaj nicotinic acid.

Barbiturates, rifampicin thiab phenytoin tseem tuaj yeem txo cov nyhuv hypoglycemic ntawm glycidone.

Kev muaj zog lossis ua rau lub zog ntawm cov nyhuv hypoglycemic ntawm glycvidone tau piav qhia nrog histamine H blockers₂receptors (cimetidine, ranitidine) thiab ethanol.

Sab sij huam

Los ntawm cov kab mob hemopoietic: thrombocytopenia, leukopenia, agranulocytosis.

Los ntawm sab ntawm cov metabolism: hypoglycemia.

Los ntawm cov kab mob hauv lub cev: mob taub hau, kiv taub hau, tsaug zog, nqaij tawv, hnov ​​nkees.

Los ntawm ob sab ntawm cov khoom ntawm kev pom: txoj kev ua txhaum kev pab.

Los ntawm cov hlab plawv system: angina pectoris, extrasystole, hlab plawv tsis ua hauj lwm, hypotension.

Los ntawm lub plab zom mov: tsis qab los, xeev siab, ntuav, cem quav, raws plab, tsis xis nyob hauv plab, qhov ncauj qhuav, cholestasis.

Los ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: pob khaus, khaus, urticaria, Stevens-Johnson syndrome, tshuaj tiv thaiv kev tawm tsam.

Lwm yam: mob hauv siab.

Cev xeeb tub thiab lactation

Tsis muaj ntaub ntawv qhia txog kev siv glycidone rau cov poj niam thaum lub cev xeeb tub thiab kev pub niam mis.

Tsis paub meej tias glycidone lossis nws cov khoom (metabolites) kis mus rau niam mis. Cov poj niam cev xeeb tub uas muaj ntshav qab zib yuav tsum ua tib zoo saib xyuas ntshav qabzib ntau. Kev noj tshuaj tiv thaiv kab mob hauv qhov ncauj hauv cov poj niam cev xeeb tub tsis muaj kev tswj txaus ntawm cov theem ntawm cov metabolism. Yog li, kev siv cov tshuaj Glurenorm ® thaum cev xeeb tub thiab lactation yog contraindicated.

Thaum cev xeeb tub lossis thaum npaj lub sijhawm cev xeeb tub thaum lub sijhawm siv cov tshuaj Glyurenorm ®, cov tshuaj yuav tsum tsis ua haujlwm ntxiv thiab hloov mus rau cov tshuaj insulin.

Siv rau lub siab ua haujlwm tsis zoo

Cov tshuaj yog contraindicated nyob rau hauv siab mob hepatic porphyria, mob siab hnyav tsis ua haujlwm.

Kev noj ib koob tshuaj tshaj 75 mg rau hauv cov neeg mob uas lub siab tsis zoo ua haujlwm yuav tsum ua tib zoo saib xyuas tus neeg mob lub sijhawm. Cov tshuaj yuav tsum tsis txhob raug rau cov neeg mob uas muaj lub siab ua haujlwm tsis zoo, vim 95% ntawm qhov koob tshuaj yog metabolized hauv lub siab thiab tawm hauv cov hnyuv. Hauv kev sim kho mob hauv cov neeg mob ntshav qab zib mellitus thiab mob siab rau lub siab ua rau lub cev sib txawv (suav nrog mob siab ua rau mob ntshav qis nrog portal hypertension), Glurenorm ® tsis ua rau lub siab txuas ntxiv ntawm lub siab ua haujlwm, qhov ntau zaus ntawm kev mob tshwm sim tsis nce ntxiv, cov tshuaj tiv thaiv qog ua kom tsis pom.

Siv rau lub raum tsis zoo muaj nuj nqi

Txij li thaum qhov tseem ceeb ntawm cov tshuaj tawm hauv cov hnyuv, hauv cov neeg mob uas tsis zoo lub raum, cov tshuaj tsis nthuav tawm. Yog li no, glycidone tuaj yeem kho zoo rau cov neeg mob uas muaj kev pheej hmoo ntawm kev mob nephropathy mob nyhav.

Kwv yees li 5% ntawm cov tshuaj metabolites yog ua rau lub raum. Hauv qhov kev tshawb fawb soj ntsuam - kev sib piv ntawm cov neeg mob ntshav qab zib mellitus thiab lub raum tsis ua haujlwm ntawm kev ua kom txawv txav thiab cov neeg mob ntshav qab zib tsis muaj qhov tsis ua haujlwm rau lub raum, noj Glyurenorm ntawm ib zaug ntawm 40-50 mg ua rau muaj kev cuam tshuam zoo xws li ntshav ntshav qabzib. Kev khaws cia ntawm cov tshuaj thiab / lossis cov tsos mob hypoglycemic tsis tau pom. Yog li, hauv cov neeg mob uas muaj mob raum tsis ua hauj lwm, tsis tas yuav hloov kho koob tshuaj.