Lozarel Ntxiv > Kev khomob thiab kev tiv thaiv

Lozarel Plus: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Losarel Plus

ATX Code: C09DA01

Tus nquag ua hauj lwm: hydrochlorothiazide (Hydrochlorothiazide) + losartan (Losartanum)

Chaw tsim tshuaj paus: LEK hnub (LEK d.d.) (Slovenia)

Qhia kho cov lus piav qhia thiab yees duab: 11.28.2018

Cov nqi hauv khw muag tshuaj: los ntawm 120 rubles.

Lozarel Plus yog qhov tshuaj tiv thaiv kev tiv thaiv kab mob.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv muab cov koob tshuaj - cov yeeb yaj kiab-pleev xim pob: puag ncig, biconvex, hauv lub plhaub daj lub teeb, nrog rau qhov tseem ceeb los ntawm dawb nrog lub pob khawm daj rau xim dawb (hauv ib pob ntawv ntawm 3-6, 8, 10 lossis 14 blister pob uas muaj 7 lossis 10 ntsiav tshuaj, thiab cov lus qhia rau kev siv Lozarel Plus).

Cov tshuaj muaj pes tsawg leeg ntawm 1 ntsiav tshuaj (12.5 mg + 50 mg) / (25 mg + 100 mg) suav nrog:

cov tshuaj nquag: hydrochlorothiazide - 12.5 / 25 mg, poov tshuaj losartan - 50/100 mg (suav nrog losartan - 45.8 / 91.6 mg thiab potassium - 4.24 / 8.48 mg),
Cov khoom siv sib xyaw (cov tub ntxhais): microcrystalline cellulose - 60/120 mg, lactose monohydrate - 26.9 / 53.8 mg, pregelatinized hmoov txhuv nplej siab - 23.6 / 47.2 mg, colloidal silicon dioxide - 0.5 / 1 mg, stearate magnesium - 1.5 / 3 mg,
zaj duab xis txheej: hyprolose - 1.925 / 3.85 mg, hypromellose - 1.925 / 3.85 mg, titanium dioxide - 1.13 / 2.26 mg, zas hlau oxide daj - 0.02 / 0.04 mg.

Cov chaw muag tshuaj

Lozarel Plus yog qhov sib xyaw ua ke ntawm losartan (ib qho tshuaj angiotensin II receptor antagonist) thiab hydrochlorothiazide (thiazide diuretic). Kev sib xyaw ntawm cov tshuaj no muaj cov nyhuv tawm tsam ntxiv thiab txo cov ntshav siab (ntshav siab) kom ntau dua hauv kev sib piv nrog kev siv cov feem no ua kev kho mob monotherapy.

Cov nyhuv ntxig ntawm Lozarel Plus siv tau ntev li 24 teev, qhov kev kho mob siab tshaj plaws feem ntau tau ua tiav nyob rau hauv plaub lub lis piam tom qab nkag.

Cov Tshuaj Hauv Tshuaj

Losartan yog ib qho tshwj xeeb ntawm kev tiv thaiv kabmob ntawm angiotensin II receptors (hom AT1). Tom qab nws txoj kev tswj hwm, angiotensin II xaiv khi rau AT1 receptors nyob rau hauv cov nqaij sib txawv (hauv cov qog adrenal, cov leeg nqaij ntawm cov hlab ntshav, lub plawv thiab ob lub raum), thiab ntau lub zog tseem ceeb ua tau, suav nrog kev tso tawm ntawm aldosterone thiab vasoconstriction. Angiotensin II tseem muaj kev cuam tshuam cov kev loj hlob ntawm cov leeg hlwb muaj zog.

Raws li cov txiaj ntsig ntawm cov kev tshawb fawb, losartan thiab nws cov metabolite E-3174, qhia kev ua haujlwm pharmacological, thaiv tag nrho cov kev mob tshwm sim ntawm lub cev ntawm angiotensin II, tsis hais txog qhov chaw los yog txoj kev ntawm nws cov biosynthesis.

Losartan ACE (angiotensin hloov mus rau enzyme), uas tsis inhibit kininase II, thiab, raws li, tsis tiv thaiv kev puas tsuaj ntawm bradykinin. Yog li, txoj kev tsis zoo uas cuam tshuam nrog kev zwm nrog bradykinin (tshwj xeeb, mob caj dab) yog qhov tsis tshua muaj tshwm sim. Losartan thiab nws cov metabolite nquag muaj kev paub zoo dua rau angiotensin I receptors dua li rau angiotensin II receptors. Lub cev ua kom nquag plias metabolite ntawm losartan yog yam muaj zog dua li cov tshuaj, kwv yees li 10-40 zaug. Plasma cov ntsiab lus ntawm losartan thiab nws cov metabolite nyob rau hauv cov ntshav, nrog rau cov nyhuv antihypertensive ntawm cov khoom nce ntxiv nyob ntawm koob tshuaj Losarel Plus. Txij li thaum losartan thiab nws cov metabolite nquag yog cov tawm tsam ntawm angiotensin II receptors, lawv ob leeg ua rau muaj cov nyhuv hypotensive.

Cov kev cuam tshuam tseem ceeb ntawm losartan thiab nws cov khoom noj khoom haus E-3174:

ib qho kev txo qis hauv ntshav siab thiab ntshav siab hauv cov hlab ntsws, ib qho kev txo qis ntawm tag nrho cov kev tawm tsam ntawm cov hlab ntshav thiab cov concentration ntawm aldosterone hauv cov ntshav,
tom qab txo nqi
kev muab cov nyhuv diuretic,
tiv thaiv kev txhim kho ntawm myocardial hypertrophy,
ntxiv kev tawm dag zog hauv kev mob siab rau cov neeg mob lub plawv tsis ua hauj lwm (mob plawv tsis ua hauj lwm),
kev ruaj khov ntawm lub plasma concentration ntawm urea hauv cov ntshav.

Ob leeg losartan thiab nws cov metabolite nquag tsis cuam tshuam rau tus neeg tsis tshua mob siab; lawv tsis muaj lub txiaj ntsig ntev ntev ntawm lub plasma concentration ntawm norepinephrine hauv cov ntshav.

Cov nyhuv antihypertensive (nyob rau hauv daim ntawv ntawm qhov txo qis hauv systolic thiab diastolic ntshav siab) tom qab ib qho kev tswj hwm qhov ncauj tau nce mus txog nws tus nqi siab tshaj plaws nyob rau hauv 6 teev, tom qab ntawd cov nyhuv poob qis dua 24 teev. Qhov siab tshaj plaws antihypertensive nyhuv loj hlob tuaj tom qab 3-6 lub lis piam ntawm kev kho mob.

Raws li tau tsim hauv cov kev soj ntsuam hauv chaw kho mob uas muaj feem cuam rau cov neeg mob uas mob sib khuav thiab tsis tshua mob heev los ntawm cov mob ntshav siab, qhov kev poob qis tseem ceeb ntawm systolic thiab diastolic ntshav siab tau pom los ntawm kev noj losartan ib zaug ib hnub. Thaum sib piv cov ntshav siab ntsuas li 5-6 thiab 24 teev tom qab noj ib zaug ntawm Lozarel Plus, nws tau pom tias thaum tswj hwm cov kev ua haujlwm txhua hnub, ntshav siab tseem qis li 24 teev. Thaum kawg ntawm lub sijhawm noj tshuaj, qhov txo qis ntshav siab yog kwv yees li 70-80% ntawm cov txiaj ntsig uas tau pom nyob hauv 5-6 teev tom qab kev tswj hwm ntawm losartan.

Thaum losartan raug txiav tawm los ntawm cov neeg mob uas mob ntshav liab, qhov ntshav nce siab ntau (qhov kev tshem tawm tsis txaus) tsis pom. Qhov khoom ntawd, txawm hais tias txo qis ntshav siab, tsis muaj kev cuam tshuam loj hauv lub plawv.

Kev kho mob zoo ntawm losartan tsis yog nyob ntawm poj niam txiv neej thiab lub hnub nyoog ntawm tus neeg mob.

Hydrochlorothiazide

Hydrochlorothiazide yog thiazide diuretic. Nws cov txiaj ntsig tseem ceeb yog kev ua txhaum ntawm kev rov ua haujlwm ntawm chlorine, sodium, magnesium thiab potassium ions nyob rau hauv lub distal nephron, ua rau muaj kev ncua hauv kev ncua ntawm uric acid thiab calcium. Nrog rau qhov nce ntxiv hauv lub raum tsis ua haujlwm ntawm cov ions no, qhov nce ntxiv ntawm cov zis tau sau tseg (vim yog osmotic khi ntawm cov dej).

Cov tshuaj txo cov khoom ntim ntawm cov ntshav plasma, thaum qhov kev ua si ntawm renin hauv cov ntshav plasma nce ntxiv thiab biosynthesis ntawm aldosterone yog kho kom zoo. Hydrochlorothiazide nyob rau hauv cov koob tshuaj siab ua rau muaj kev nce ntxiv hauv kev nthuav dav ntawm bicarbonates, nrog rau siv ntev - kom txo qis hauv cov calcium uas ua kom tsis haum. Cov nyhuv antihypertensive tsim tawm vim qhov txo qis hauv lub ntim ntawm cov ntshav ncig, kev hloov pauv ntawm cov keeb kwm vascular phab ntsa, qhov txo qis ntawm cov nyhuv pressor ntawm vasoconstrictive amines (adrenaline, norepinephrine) thiab qhov nce ntawm qhov cuam tshuam ntxim nyiam ntawm ganglia. Cov tshuaj tsis cuam tshuam rau cov ntshav siab li qub. Cov nyhuv diuretic raug pom nyob hauv 1-2 teev, cov txiaj ntsig siab tshaj plaws tsim tawm hauv 4 teev, lub sijhawm ntawm cov diuretic nyhuv yog li ntawm 6 txog 12 teev.

Kev kho mob nyhuv tshwm sim tom qab 3-4 hnub ntawm kev tswj hwm, tab sis nws yuav siv sijhawm ntev li 3 mus rau 4 lub lis piam kom ua tiav cov txiaj ntsig hypotensive zoo.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, losartan yog qhov zoo nqus tau ntawm txoj hnyuv. Nws yog metabolized thaum thawj txoj kev hla mus rau daim siab los ntawm carboxylation nrog kev koom tes ntawm cytochrome CYP2C9 isoenzyme, nrog kev tsim cov metabolite nquag. Txheej txheem kev nyab xeeb ntawm cov neeg nruab nrog kom txog li ntawm 33%. Kev noj haus tsis cuam tshuam qhov ntsuas no. Lub sijhawm mus txog C_max (qhov siab tshaj plaws) ntawm losartan thiab nws cov nquag metabolite hauv cov ntshav cov ntshav tom qab kev tswj hwm qhov ncauj - 1 thiab 3-4 teev, ua ntu zus.

Qhov tshuaj thiab nws cov nquag metabolite khi rau ntshav protein nyob rau theem ntawm ntau dua 99%, feem ntau nrog albumin. V_d (xa tawm ntim) yog 34 litres. Losartan kev siv tsis nkag rau cov ntshav-hlwb teeb meem.

Cov kev hloov pauv ntawm cov chaw muag tshuaj ntawm cov tshuaj thiab nws lub zog metabolite tom qab noj li 200 mg ntawm losartan yog nyob rau ntawm txoj kab sib piv rau cov koob tshuaj.

Nrog rau kev tswj hwm ntau zaus ntawm 1 zaug nyob rau ib hnub, ib qho tseem ceeb tsub zuj zuj ntawm losartan thiab nws cov metabolite hauv cov ntshav ntshav tsis pom. Kev siv ib zaug hauv ib koob 100 mg ib zaug tsis ua rau muaj qhov tshwj xeeb ntau ntawm cov tshuaj thiab nws cov metabolite hauv ntshav ntshav.

Txog li 4% ntawm cov koob tshuaj ntawm losartan tau hloov pauv mus rau hauv qhov chaw metabolite. Tom qab noj ntawm daim ntawv lo 14 C nrog losartan, lub radioactivity ntawm cov ntshav ntshav yog feem ntau ua rau muaj cov tshuaj thiab nws cov metabolite nyob hauv nws. Hauv kwv yees li ntawm 1% ntawm cov neeg mob, muaj qhov qis ntawm losartan metabolism pom.

Plasma thiab lub raum tshem tawm yog (feem): losartan - kwv yees li 600 thiab 74 ml / min, nws cov nquag metabolite - li 50 thiab 26 ml / min. Li ntawm 4% ntawm cov koob tshuaj ntawm losartan yog tawm tsis hloov pauv los ntawm ob lub raum, kwv yees li 6% - raws li kev siv metabolite. Plasma cov ntsiab lus ntawm cov tshuaj thiab nws cov metabolite txo qis tshaj tawm nrog T kawg_1/2 (tshem tawm ib nrab-lub neej) txog 2 thiab 6–9 teev, ua ntu zus. Kev zam yog nqa tawm los ntawm ob lub raum thiab nrog bile. Tom qab tau txais daim ntawv lo 14 C ntawm losartan, kwv yees li 58% ntawm xov tooj cua tau pom nyob hauv cov quav, 35% hauv cov zis.

Tawm tsam cov keeb kwm yav dhau los ntawm qhov mob sib khuav ntawm qhov mob sib khuav ntawm kev haus cawv ua lub siab, nyob rau hauv kev sib piv nrog cov txiv neej noj qab haus huv zoo, cov concentration ntawm losartan thiab cov metabolite nquag nce los ntawm 5 thiab 1.7 npaug, feem.

Qhov siab ntawm losartan nyob rau hauv cov ntshav ntshav nrog CC (creatinine tshem tawm) saum toj no 10 ml / min tsis txawv qhov ntawd los ntawm qhov tsis muaj qias neeg lub raum muaj nuj nqi. Hauv cov neeg mob hemodialysis, tus nqi AUC (thaj chaw nyob rau hauv qhov chaw siab-lub sijhawm nkhaus) yog kwv yees li 2 npaug siab dua thaum tsis muaj qhov tsis ua haujlwm lub raum. Nrog rau cov mob hemodialysis, losartan thiab cov tshuaj tiv thaiv metabolite tsis tau muab tshem tawm.

Hauv cov poj niam uas mob ntshav nce hlwb, qhov tseem ceeb ntawm plasma ntau ntawm losartan ntau dua qhov tseem ceeb hauv cov txiv neej los ntawm qhov feem ntawm ob, thaum nyob hauv tus txiv neej thiab poj niam qhov ntau ntawm lub zog metabolite tsis txawv. No qhov txawv txawv pharmacokinetic tsis muaj qhov tseem ceeb kho mob.

Cov Yuav Tsum Tau Ua

mob raum tsis ua haujlwm (hauv cov neeg mob CC tsawg dua 30 ml / min),
mob rau daim siab hnyav (raws li Tus Me Nyuam - Haus dej haus ntau, ntau dua 9 ntsiab lus),
Kev Mob Nkeeg
lactase deficiency, malabsorption syndrome thiab lactose tsis haum,
Addison's disease
cov tsos mob gout thiab / lossis hyperuricemia,
refractory hyper- thiab hypokalemia, hypercalcemia, refractory hyponatremia,
lub cev qhuav dej, nrog rau cuam tshuam nrog kev siv qhov siab ntawm cov tshuaj diuretics,
nyuaj los tswj ntshav qab zib
arterial siab hypotension,
kev sib txuas ua ke nrog kev kho mob aliskiren thiab aliskiren-muaj cov tshuaj hauv cov neeg mob uas lub raum tsis ua haujlwm (nrog lub qog ua kua ntawm 2) thiab / lossis ntshav qab zib mellitus,
cev xeeb tub thiab lactation,
hnub nyoog txog 18 xyoo
kev tsis haum xeeb rau cov tshuaj ntawm cov tshuaj, nrog rau cov tshuaj uas yog derivatives ntawm sulfonamide.

Tus Txheeb Ze (Lozarel Plus tau raug coj los ntawm kev saib xyuas mob):

kev sib txuas ua ke nrog kev siv tshuaj tsis-tshuaj steroidal (suav nrog nrog cyclooxygenase-2 inhibitors),
cerebrovascular tsis txaus,
kev ua txhaum ntawm cov dej-electrolyte sib npaug ntawm cov ntshav, piv txwv, cuam tshuam nrog zawv plab lossis ntuav (hyponatremia, hypomagnesemia, hypochloremic alkalosis),
ob leeg lub raum leeg mob stenosis los yog leeg ntshav ntawm ib raum,
lub raum tsis ua haujlwm (hauv cov neeg mob CC 30-50 ml / min),
cov tshuaj tiv thaiv keeb kwm thiab mob ntsws asthma,
mob siab mob rau daim siab thiab muaj mob ua rau daim siab tsis ua haujlwm (raws li tus me nyuam-Pugh nplai, qis dua 9 ntsiab lus),
cov kab mob cov kab mob ntawm cov nqaij sib txuas (suav nrog cov kab mob lupus erythematosus),
lub plawv tsis ua hauj lwm nrog lub neej tsis xwm yeem,
stenosis ntawm aorta lossis mitral valve,
Tus mob myopia thiab lub kaum ob lub qhov muag ntsej muag (cuam tshuam nrog hydrochlorothiazide),
mob plawv plawv
hypertrophic obstructive cardiomyopathy,
thawj hyperaldosteronism,
tej yam kev mob tom qab hloov raum (tsis muaj kev paub nrog kev siv),
mob ntshav qab zib mellitus
teej tug rau cov haiv neeg dub.

Sab sij huam

Hauv kev sim kho mob nrog losartan thiab hydrochlorothiazide, cov kev phiv tshuaj tsis zoo rau cov tshuaj no ua ke tsis tau pom.

Cov kev mob tshwm sim tau txwv rau cov uas twb tau qhia lawm thaum siv cov khoom xyaw nquag ntawm Losarel Plus ua kev kho mob hlwb. Nyob rau hauv tag nrho, qhov ntsuas ntau zaus los ntawm qhov tsis zoo qhia nrog kev sib xyaw no tau piv rau qhov ntawd nrog cov placebo.

Feem ntau, kev sib xyaw ua ke nrog losartan thiab hydrochlorothiazide muaj kev tiv thaiv zoo. Feem ntau, kev phiv tshuaj yog qhov mob me, hloov mus rau qhov xwm txheej thiab tsis ua rau txo qis ntawm Lozarel Plus.

Raws li cov txiaj ntsig ntawm kev tswj xyuas cov kab mob kev soj ntsuam, hauv kev kho mob ntawm qhov tseem ceeb ntawm kev kub siab, tsuas yog qhov tsis xav tau cuam tshuam nrog Lozarel Plus kev tswj hwm, qhov ntau zaus uas tau dhau uas nrog cov placebo ntau dua 1%, yog kiv taub hau.

Tsis tas li, thaum ua kev tshawb fawb, nws tau pom tias nyob rau hauv cov neeg mob laug laug ventricular hypertrophy thiab hlab ntsha tawg, cov kev tsis sib haum xeeb feem ntau yog: kev ua kom nkees nkees, tsis muaj zog, tsis muaj zog / tsis muaj lub cev tsis ua haujlwm.

Hauv kev kawm ntawm ntau qhov kev tshawb fawb, suav nrog kev soj ntsuam tom qab soj ntsuam, cov kev mob tshwm sim tom qab tau sau cia> 10% - ntau zaus (> 1% thiab 0.1% thiab 0.01% thiab 5.5 mmol / L), ua rau tsis xws luag - nce ntawm cov ntshav urea concentration. / cov pa tshuaj nitrogen thiab creatinine nyob rau hauv cov ntshav, tsis tshua muaj siab hyperbilirubinemia, qhov nce me ntsis hauv kev ua si ntawm hepatic transaminases (aspartate aminotransferase thiab alanine aminotransferase), nrog rau qhov tsis muaj ntau zaus - hyponatremia,

cov teeb meem dav dav: feem ntau - cov rog nkees ntau ntxiv, asthenia, peripheral edema, mob hauv siab hauv siab, tsis xws luag - kub taub hau, o ntawm lub ntsej muag, nrog qhov tsis paub kawg - cov tsos mob ua npaws, malaise.

Muaj kev phiv tshuaj los ntawm cov kab ke thiab kabmob vim hydrochlorothiazide:

hlab plawv system: ua haujlwm dhau los - orthostatic hypotension, arrhythmias, vasculitis,
mob plab zom mov: ua haujlwm dhau los - ua rau lub plab ua kom tsis haum plab, cholestatic jaundice, mob chraestatic cholestasis, cholecystitis lossis pancreatitis, raws plab, ntuav, xeev siab, ntuav, cem quav, sialadenitis, tsis nco qab,
cov kab mob hauv lub raum: tso zis tsis tu ncua - interstitial nephritis, lub raum tsis ua haujlwm, lub raum tsis ua haujlwm,
cov leeg hlwb: feem ntau - mob taub hau, tsis txaus ntseeg - kiv taub hau, mob caj dab, pw tsis tsaug zog,
kev tiv thaiv kab mob: ua rau tsis muaj zog - ua pa nyuaj syndrome (suav nrog cov mob tsis-cardiogenic pulmonary edema thiab mob ntsws), urticaria, necrotic vasculitis, purpura, Stevens-Johnson syndrome, tsis tshua muaj - anaphylactic kev cuam tshuam, muaj peev xwm poob siab,
ntshav thiab lymphatic system: ua haujlwm tsis zoo - thrombocytopenia, leukopenia, agranulocytosis, aplastic / hemolytic anemia,
yam khoom ntawm lub zeem muag: dhau los - xantopsia, plooj plooj tsis pom kev, ib ntus uas tsis paub kawg - lub kaum ntse ntse lub qhov muag tsis pom kev,
daim tawv nqaij thiab cov nqaij mos ua kom tawg: ua haujlwm dhau los - muaj cov kab mob lom tsis haum, ua kom lub ntsej muag, nrog lub cev tsis muaj caij nyoog - lupus erythematosus,
metabolism thiab zaub mov noj qab haus huv: ua tsis tau - hypomagnesemia, hypokalemia, hyperglycemia, hyponatremia, glucosuria, hyperuricemia nrog kev loj hlob ntawm kev tawm tsam ntawm gout, hypercalcemia thiab hypochloremic alkalosis (tshwm sim hauv daim ntawv ntawm xerostomia, nqhis dej, mob plawv tsis txaus, hloov pauv hauv psyche / siab ntsws) mob leeg, xeev siab, ntuav, txawv txawv lossis tsis muaj zog, hypochloremic alkalosis tuaj yeem ua rau mob hepatic encephalopathy / mob hepatic tsis nco qab), hyponatremia (tshwm sim los tsis meej pem, nriaj) , Nkees, qeeb xav txheej txheem, excitability, qaug zog, mob tu-sauv) thaum lub sij hawm txoj kev kho thiazide tejzaum lus zib kam rau ua, lub ntws tej zaum yuav tshwm sim latent mob ntshav qab zib mellitus, nyob rau hauv cov ntaub ntawv ntawm siab koob tshuaj yuav ua rau kom lub ntshiab concentration ntawm lipids nyob rau hauv cov ntshav,
lwm tus: ua haujlwm tsis xws luag - cov pob tw leeg, txo qis potency.

Noj ntau dhau

Cov tsos mob tseem ceeb ntawm kev siv ntau dhau ntawm cov nquag ua haujlwm ntawm Lozarel Ntxiv:

losartan: tachycardia, cim txo hauv ntshav siab, bradycardia (cuam tshuam nrog qhov chaw mos),
hydrochlorothiazide: poob ntawm electrolytes (nyob rau hauv daim ntawv ntawm hypokalemia, hyperchloremia, hyponatremia), nrog rau lub cev qhuav dej, uas muaj kev txhim kho vim ntau diuresis, nyob rau hauv cov ntaub ntawv ntawm concomitant siv nrog plawv glycosides, hypokalemia tuaj yeem ua rau lub zog ntawm kev tsis tuaj yeem.

Kev Kho Mob: kev txhawb nqa thiab tsos mob. Yog tias lub sijhawm me ntsis tau dhau mus txij thaum txais tos, koj yuav tsum yaug lub plab, raws li kev taw qhia, kev kho ntawm cov dej-electrolyte cuam tshuam tau nqa tawm. Losartan thiab nws cov metabolites ua haujlwm tsis tshem tawm los ntawm hemodialysis.

Dosage daim ntawv

Zaj duab xis-cov ntsiav tshuaj 50 mg / 12.5 mg, 100 mg / 25 mg

Ib ntsiav tshuaj muaj

cov tshuaj nquag: losartan poov tshuaj 50 mg, hydrochlorothiazide 12.5 mg los yog

losartan poov tshuaj 100 mg, hydrochlorothiazide 25 mg

kev zam: lactose monohydrate, microcrystalline cellulose, hmoov txhuv nplej tshiab pregelatinized, magnesium stearate, anhydrous colloidal silicon dioxide

lub plhaub muaj pes tsawg leeg: hypromellose, hydroxypropyl cellulose, daj hlau oxide (E 172), titanium dioxide (E 171), macrogol (400) (rau kev noj tshuaj ntawm 100 mg / 25 mg), talc (rau tshuaj rau 100 mg / 25 mg).

Zaj yeeb yaj kiab-xaum xim, lub teeb daj hauv cov xim, puag ncig lub cev, nrog lub ntsej muag biconvex.

Tsuas tshuaj thiab tswj hwm

Lozarel Plus tuaj yeem tsim kho nrog lwm cov tshuaj tiv thaiv kab mob siab.

Cov ntsiav tshuaj yuav tsum tau siv qhov ncauj nrog lub khob dej, tsis hais qhov noj mov.

Cov poov tshuaj losartan thiab hydrochlorothiazide tsis kam lees txais kev kho mob thaum pib, tab sis raug kho rau cov neeg mob uas siv losartan potassium lossis hydrochlorothiazide cais tsis ua rau kev tswj ntshav siab txaus.

Kev pom zoo koob tshuaj ntawm txhua ntawm ob qho kev sib xyaw (poov tshuaj losartan thiab hydrochlorothiazide) raug pom zoo.

Thaum muaj kev kho mob tsim nyog, hauv cov neeg mob uas lawv cov ntshav siab tsis yog tswj tau, kev hloov pauv ncaj qha ntawm monotherapy mus rau kev sib xyaw ua ke yuav suav tau.

Lozarel Ntxiv 50 mg / 12.5 mg zaj duab xis-ntsiav tshuaj

Kev saib xyuas txij li niaj zaus: 1 ntsiav tshuaj 50 mg / 12.5 mg 1 zaug ib hnub.

Rau cov neeg mob uas tsis muaj lus teb txaus, qhov koob tshuaj yuav raug nce ntxiv rau 2 ntsiav tshuaj ntawm 50 mg / 12.5 mg ib hnub ib zaug lossis 1 ntsiav tshuaj ntawm 100 mg / 25 mg ib hnub ib zaug.

Raws li txoj cai, cov nyhuv antihypertensive tau tiav hauv 3-4 lub lis piam tom qab pib kho.

Lozarel Plus, cov ntsiav tshuaj zaj duab xis-100 mg / 25 mg Qhov koob tshuaj ntau: 1 ntsiav tshuaj 100 mg / 25 mg ib hnub ib zaug.

Raws li txoj cai, cov nyhuv antihypertensive tau tiav hauv 3-4 lub lis piam tom qab pib kho.

Siv rau hauv cov neeg mob uas lub raum tsis ua hauj lwm thiab hauv cov neeg mob ntawm hemodialysis.

Hauv cov neeg mob uas muaj mob tsis ua hauj lwm lub raum (i.e. creatinine tshem tawm yog 30-50 ml / min), tsis tas yuav pib kho kom haum cov koob. Kev sib xyaw ntawm losartan-hydrochlorothiazide tsis pom zoo rau cov neeg mob ntawm hemodialysis. Kev sib xyaw ua ke ntawm losartan-hydrochlorothiazide yuav tsum tsis txhob muab rau cov neeg mob uas lub raum tsis ua haujlwm zoo (creatinine tshem tawm)

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, 1 lub sijhawm nyob rau ib hnub, tsis hais txog ntawm kev ua zaub mov.

Nrog rau cov hlab ntsha o, qhov ib txwm pib thiab txij nkawm cov tshuaj ntawm cov tshuaj yog 1 tab. LozarelR Ntxiv 12,5 mg + 50 mg / hnub.

Thaum tsis muaj cov tshuaj kho kom zoo txaus nyob rau hauv 3-4 lub lis piam, qhov koob tshuaj yuav tsum tau nce rau 2 ntsiav tshuaj ntawm LozarelR Ntxiv 12,5 mg + 50 mg lossis 1 ntsiav tshuaj ntawm LozarelR Plus 25 mg + 100 mg (qhov siab tshaj ib hnub).

Hauv cov neeg mob uas txo qis cov ntshav ncig (piv txwv li, thaum noj cov tshuaj diuretics), qhov pom zoo thawj zaug ntawm losartan yog 25 mg ib hnub ib zaug. Hauv qhov no, LozarelR Plus kev kho mob yuav tsum tau pib tom qab lub diuretics raug tso tseg thiab hypovolemia raug kho.

Rau cov neeg laus thiab cov neeg mob raum tsis ua hauj lwm zoo, suav nrog kev lim ntshav, tsis tas yuav tau txhaj koob tshuaj.

Pharmacological kev txiav txim

Lozarel Plus yog qhov sib xyaw ntawm cov tshuaj angiotensin II receptor antagonist (losartan) thiab thiazide diuretic (hydrochlorothiazide). Kev sib xyaw ua ke ntawm cov cheebtsam no muaj cov nyhuv ua rau muaj zog ntxiv thiab txo cov ntshav siab (BP) kom ntau dua txhua ntu ntawm cov khoom sib cais.

Kev sib txuam

Nrog tib lub sijhawm siv thiazide diuretics nrog barbiturates, narcotic analgesics, ethanol, kev pheej hmoo ntawm kev tsim orthostatic hypotension yog ua tau.

Diuretics txo txoj kev rov ua haujlwm ntawm kev ua haujlwm ntawm cov roj ntsha thiab ua rau muaj kev pheej hmoo ntawm nws cov tshuaj lom neeg, ua ke siv cov tshuaj diuretics thiab lithium npaj tsis pom zoo.

Nrog rau kev siv tib lub sijhawm nrog pressor amines (norepinephrine, epinephrine), qhov txo qis me ntsis hauv cov nyhuv ntawm pressor amines yog ua tau, uas tsis cuam tshuam nrog lawv cov kev tswj hwm, nrog cov tsis-depolarizing nqaij relaxants (tubocurarine) - qhov nce ntawm lawv cov nyhuv.

Nrog rau kev siv glucocorticosteroids, adrenocorticotropic hormone (ACTH), nws muaj peev xwm ua kom nce qhov ploj ntawm electrolytes, exacerbating hypokalemia. Thiazides tuaj yeem txo lub raum tsis ua haujlwm ntawm cov tshuaj cytotoxic thiab txhim kho lawv cov nyhuv myelosuppressive.

Cov lus qhia tshwj xeeb

Cov tshuaj uas muaj kev cuam tshuam rau RAAS (renin-angiotensin-aldosterone system) hauv cov neeg mob uas muaj ob leeg lub raum leeg mob stenosis los yog stenosis ntawm ib lub raum artery tuaj yeem nce ntshav urea thiab serum creatinine. Cov teebmeem zoo li no tau sau tseg nrog losartan. Cov tsis ua hauj lwm mob raum yeej thim rov qab thiab dhau mus tom qab kev tsis mus kho. Muaj pov thawj tias nyob hauv qee cov neeg mob noj tshuaj, thim rov qab kev hloov pauv ntawm kev ua haujlwm hauv lub raum, suav nrog lub raum tsis ua haujlwm, tshwm sim vim kev tsuj ntawm RAAS kev ua haujlwm.

Ib yam li kev siv lwm yam tshuaj nrog cov txiaj ntsig hypotensive, vim qhov txiaj ntsig ntawm ntshav ntau dhau los hauv ischemic hlab plawv thiab kab mob cerebrovascular, myocardial infarction thiab mob stroke tuaj yeem tsim kho.

Hauv cov neeg mob uas lub plawv tsis ua haujlwm nrog / tsis muaj qhov tsis ua haujlwm raum, mob raum tsis ua haujlwm thiab txo qis ntshav siab yog tau.

Zoo li lwm cov angiotensin II receptor antagonists, losartan tsis muaj txiaj ntsig zoo rau cov neeg mob ntawm cov haiv neeg Negroid, uas cuam tshuam nrog qis renin kev ua si.

Hauv cov neeg mob tom qab hloov raum, tsis muaj kev paub nrog kev siv losartan.

1. Kev ntsuas rau siv

Cov tshuaj Lozarel tau sau tseg yog tias muaj:

Pom cov cim ntawm kub siab.
Txo txoj kev pheej hmoo ntawm cuam tshuam txog kev mob plawv hauv cov neeg muaj kev txom nyem los ntawm cov hlab ntsha txhaws los yog sab laug ventricular hypertrophy, uas tau tshwm sim los ntawm kev txo qis hauv cov zaus ntawm cov kab mob plawv tuag, mob hlab ntsha tawg thiab myocardial infarction.
Muab kev tiv thaiv raum hauv cov neeg mob ntshav qab zib hom 2.
Qhov xav tau kom txo cov proteinuria.
Mob plawv tsis ua hauj lwm nrog kev kho mob tsis ua hauj lwm los ntawm ACE inhibitors.

3. Kev sib cuam tshuam txog yeeb tshuaj

Kev sib cuam tshuam ntawm Lazorel nrog lwm cov tshuaj:

Tsis muaj kev cuam tshuam los ntawm Lozarel thiab Hydrochlorothiazide thiab Digoxin, nrog rau lwm cov tshuaj uas muaj kev cuam tshuam zoo rau tib neeg lub cev. Qee zaum ua ke ua ke nrog nws "Rifampicin" thiab "Fluconazole" ua rau txo qis hauv theem ntawm cov khoom noj tshwj xeeb hauv cov ntshav plasma.
Kev sib xyaw nrog cov tshuaj uas inhibit angiotensin II enzyme lossis nws cov kev nqis tes ua, muaj qhov nce ntxiv ntawm qhov pheej hmoo ntawm kev pheej hmoo ntawm kev txhim kho hyperkalemia.
Cov tshuaj tiv thaiv nonsteroidal tuaj yeem txo qis kev ua haujlwm ntawm angiotensin II receptor blockers.
Ua ke nrog kev kho mob nrog angiotensin II receptor antagonists thiab NSAIDs feem ntau ua rau cov teeb meem lub raum.
Kev sib xyaw ntawm angiotensin II receptor antagonists nrog lithium npaj ua rau muaj kev nce ntxiv ntawm cov lithium uas muaj nyob hauv cov ntshav ntshav.
Kev kho nrog "Losarel" ib txhij nrog kev qhia ntawm diuretics muab ib qho kev hloov kho ntxiv. Raws li qhov tshwm sim, muaj kev sib txuam rau qhov ua tau zoo ntawm ntau cov tshuaj tiv thaiv kabmob ntshav.

6. Cov lus thiab cov xwm txheej ntawm kev cia khoom

Khaws ntawm qhov kub thiab txias tsis tshaj 25 ° C. Khaws cov tshuaj tawm kom deb ntawm cov me nyuam yaus me.

Hnub tas sij hawm Cov tshuaj yog 2 xyoos.

Tsis txhob siv cov tshuaj tom qab hnub tas sij hawm.

Tus nqi ntawm cov tshuaj Lazorel sib txawv raws li qhov chaw tsim khoom thiab lub network ntawm cov chaw muag tshuaj, hauv Lavxias ntawm qhov nruab nrab nws raug nqi los ntawm 200 rubles.

Nyob rau hauv Ukraine cov tshuaj tsis nrov thoob plaws thiab raug nqi txog 200 UAH.

Yog tias tsim nyog, koj tuaj yeem hloov "Lozarel" nrog ib qho ntawm cov tshuaj no:

Brozaar
Blocktran
Vero-Losartan
Vazotens
Cardomin-Sanovel
Zisakar
Cozaar
Karzartan
Lozap,
Lakea
Losartan A,
Losartan Canon
"Losartan poov tshuaj",
Losartan Richter,
Losartan MacLeods,
Losartan Teva
"Lozartan-TAD",
Losacor
Lorista
Tubkawm Presartan
Lotor
"Renicard."

Kev siv cov analogues rau kev kho mob yog qhov tshwj xeeb tshaj yog nyob rau hauv cov mob uas tus neeg mob muaj qee leej tsis kam lees rau cov tshuaj ntawm cov tshuaj. Txawm li cas los xij, tsuas yog ib tus kws kho mob tuaj yeem sau ntawv noj tshuaj.

Piv txwv li tshuaj xyuas cov tshuaj muaj nyob hauv Is Taws Nem, piv txwv li, Anastasia sau hais tias: “Kuv cov ntshav qab zib ua rau mob hnyav. Sai sai no, Kuv tau ntsib nrog kev paub tshiab ntawm tus kab mob no. Kuv kuj tau kuaj pom muaj nephropathy. Tus kws kho mob tau sau ntau cov tshuaj sib txawv, suav nrog Lozarel. Nws yog nws leej twg pab rau sai sai thiab ua rau rov qab ua haujlwm ntawm ob lub raum. Cov ceg o tau ploj mus. "

Lwm qhov kev txheeb xyuas tuaj yeem pom tom qab kawg ntawm tsab xov xwm no.

Cov tshuaj Lozarel raug lees paub tias yog cov tshuaj zoo hauv kev kho mob siab thiab lub plawv tsis ua haujlwm. Nws tau nthuav tawm cov kab ke ntxiv nrog cov khoom sib txuam zoo sib xws, nws tsis pom zoo rau cov teeb meem ntawm daim siab thiab lub raum, zoo li thaum lub cev xeeb tub thiab qis dua 18 xyoo. Txhawm rau kom tsis txhob tshwm sim tshwm sim, nws pom zoo kom noj cov tshuaj kom nruj raws li kws kho mob tau hais tseg.

Cov ntsiav tshuaj, zaj duab xis-dawb dawb los yog dawb nrog lub ntsej muag daj, puag ncig, biconvex, muaj kev pheej hmoo ntawm ib sab.

Cov kev zam: microcrystalline cellulose, lactose monohydrate, pregelatinized hmoov txhuv nplej siab, anhydrous colloidal silicon dioxide, magnesium stearate.

Qhov muaj pes tsawg leeg ntawm cov zaj duab xis membrane: hypromellose, hyprolose, macrogol 400, titanium dioxide (E171), talc.

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.

Ib qho tshuaj tiv thaiv kab mob siab, tshuaj tiv thaiv kev tiv thaiv kabmob ntawm angiotensin II receptors (hom AT 1). Angiotensin II xaiv khi rau AT 1 receptors pom nyob rau hauv ntau cov ntaub so ntswg (nyob rau hauv cov leeg nqaij ntawm cov hlab ntsha, hauv cov qog adrenal, lub raum thiab lub plawv) thiab ua rau vasoconstriction thiab aldosterone tso tawm, du ua kom cov leeg loj.

Hauv kev tshawb pom hauv vitro thiab hauv vivo tau qhia tias losartan thiab nws cov tshuaj pharmacologically nquag metabolite thaiv tag nrho cov kev mob tseem ceeb ntawm cov tshuaj angiotensin II, tsis hais txog qhov chaw los yog txoj kev ntawm nws cov synthesis. Tsis inhibit kinase II - ib qho enzyme uas rhuav tshem bradykinin.

Nws txo OPSS, ntshav siab ntawm aldosterone, ntshav siab, cov kab mob hauv cov ntshav ntsws, txo qis tom qab, muaj cov nyhuv diuretic. Nws cuam tshuam nrog kev txhim kho myocardial hypertrophy, ua rau lub cev muaj zog ntau dua nyob rau hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev.

Tom qab ib qho kev tswj hwm ntawm qhov ncauj, qhov kev tiv thaiv hypotensive (systolic thiab diastolic ntshav siab) nce mus txog qhov siab tshaj plaws tom qab 6 teev, tom qab ntawd maj mam txo qis hauv 24 teev. Qhov siab tshaj plaws ntawm kev tiv thaiv tau nce 3-6 lub lis piam tom qab kev coj ua ib txwm siv tshuaj.

Nws tsis inhibit ACE thiab, yog li ntawd, tsis tiv thaiv qhov kev rhuav tshem ntawm bradykinin, yog li ntawd, losartan tsis muaj kev phiv los ntawm kev mob cuam tshuam nrog bradykinin (piv txwv li, angioedema).

Hauv cov neeg mob uas mob ntshav tawm tsis muaj ntshav qab zib tsis muaj concomitant mob ntshav qab zib mellitus nrog proteinuria (ntau dua 2 g / hnub), kev siv cov tshuaj txo cov proteinuria ntau, kev tsis haum ntawm albumin thiab immunoglobulins G.

Stabilizes qib ntawm urea hauv ntshav ntshav. Nws tsis muaj dab tsi cuam tshuam rau cov zaub tsis zoo ntawm lub cev, thiab tsis muaj qhov cuam tshuam ntev rau ntawm theem ntawm norepinephrine hauv cov ntshav ntshav.

Thaum lub koob tshuaj txog li 150 mg, 1 zaug / hnub tsis cuam tshuam rau theem ntawm triglycerides, tag nrho cov roj (cholesterol) thiab cov roj (HDL) cov roj (HD) hauv cov ntshav cov ntshav hauv cov neeg mob ntshav siab. Nyob rau tib lub sijhawm, losartan tsis cuam tshuam rau yoo ntshav cov ntshav.

Thaum muab tshuaj, losartan zoo tso tawm los ntawm cov hnyuv. Nws ua rau cov metabolism hauv thawj "thawj tshooj" los ntawm lub siab los ntawm carboxylation nrog kev koom tes ntawm CYP2C9 isoenzyme nrog kev tsim cov tshuaj metabolite. Txheej txheem ntawm cov neeg nruab nrog cev ntawm losartan yog li ntawm 33%. C max ntawm losartan thiab nws cov tshuaj tiv thaiv metabolite tau tiav hauv cov ntshav ntshav tom qab kwv yees li 1 teev thiab 3-4 teev tom qab noj, feem. Noj tsis txhob cuam tshuam rau lub bioavailability ntawm losartan.

Thaum noj cov tshuaj ntawm qhov ncauj hauv qhov siab txog 200 mg, losartan thiab nws cov tshuaj tiv thaiv metabolite yog tus yam ntxwv ntawm cov tshuaj pharmacokinetics.

Qhov khi ntawm losartan thiab nws cov metabolite ua rau cov ntshav protein (feem ntau nrog albumin) yog ntau dua 99%. V d losartan - 34 l. Losartan suab tsis nkag ntawm BBB.

Kwv yees li 14% ntawm losartan muab cov tshuaj iv lossis qhov ncauj rau tus neeg mob tau hloov mus ua ib qho metabolite.

Cov ntshav pliav tshem ntawm losartan yog 600 ml / min, cov metabolite nquag yog 50 ml / min. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite yog 74 ml / min, thiab 26 ml / min, feem. Thaum noj, kwv yees li 4% ntawm cov koob tshuaj noj tau tso tawm los ntawm lub raum tsis hloov pauv thiab kwv yees li 6% yog tawm los ntawm lub raum hauv daim ntawv ntawm cov tshuaj tiv thaiv metabolite. Tom qab lub qhov ncauj tswj hwm, cov ntshav plasma ntau ntawm losartan thiab nws lub zog metabolite txo qis tshaj tawm nrog qhov kawg T 1/2 ntawm losartan txog 2 teev, thiab cov nquag metabolite txog 6-9 teev. Thaum noj cov tshuaj ntawm 100 mg / hnub, tsis yog losartan lossis lub zog metabolite tseem ceeb cumulate hauv cov ntshav ntshav.

Losartan thiab nws cov metabolites yog tawm ntawm cov hnyuv thiab lub raum.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Hauv cov neeg mob uas mob sib khuav xws li cawv me ntsis txog rau kev haus dej cawv, lub siab ntawm losartan yog 5 zaug, thiab cov nquag metabolite yog 1.7 npaug ntau dua li cov txiv neej ua haujlwm pab dawb.

Nrog CC ntau dua 10 ml / min, qhov kev tso siab ntawm losartan hauv cov ntshav ntshav tsis txawv ntawm qhov ntawd nrog lub raum kev ua haujlwm.Hauv cov neeg mob uas yuav tsum muaj mob hemodialysis, tus nqi ntawm AUC yog kwv yees li 2 npaug dua li ntawm cov neeg mob uas lub raum tsis ua haujlwm.

Tsis yog losartan thiab nws lub zog metabolite raug tshem tawm ntawm lub cev los ntawm hemodialysis.

Qhov ntau ntawm losartan thiab nws cov metabolite hauv ntshav plasma hauv cov txiv neej laus uas mob ntshav tsis txawv ntau qhov tsis tseem ceeb ntawm cov txiaj ntsig ntawm cov txwv no hauv cov txiv neej hluas nrog kev mob ntshav siab.

Cov txiaj ntsig ntawm ntshav ntau ntawm losartan nyob rau hauv cov poj niam uas mob ntshav tawm tsam yog 2 npaug dua li qhov tseem ceeb hauv cov txiv neej raug kev txom nyem los ntawm kev mob ntshav siab. Kev xav ntawm lub cev zom zaub mov nquag hauv txiv neej thiab poj niam tsis txawv. No qhov txawv txawv pharmacokinetic tsis muaj qhov tseem ceeb kho mob.

- mob plawv tsis ua hauj lwm (nrog kev kho mob tsis ua hauj lwm los ntawm ACE inhibitors),

- nephropathy nyob hauv hom 2 mob ntshav qab zib mellitus (txo cov kev pheej hmoo ntawm kev tsim hypercreatininemia thiab proteinuria),

- txo qis kev pheej hmoo ntawm cov hlab plawv mob thiab tuag hauv cov neeg mob ntshav siab thiab tawm ntawm txoj hlab ntsws tawg (ventricular hypertrophy).

- lactation (pub niam mis),

- lub hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim tsa),

- lactose intolerance, galactosemia lossis glucose / galactose malabsorption syndrome,

- Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj.

Nrog kev ceev faj, cov tshuaj yuav tsum raug siv rau hepatic thiab / lossis lub raum tsis ua haujlwm, txo qis hauv bcc, tsis muaj dej-electrolyte tshuav, ob tog lub raum artery stenosis lossis stenosis ntawm ib lub raum leeg.

Cov tshuaj tau sau tawm ntawm ncauj noj 1 zaug / hnub, tsis hais txog ntawm cov zaub mov noj.

Nrog kev mob ntshav liab feem ntau, qhov pib thiab txij nkawm cov koob tshuaj yog 50 mg 1 zaug / hnub. Yog tias tsim nyog, cov koob tshuaj yuav raug nce rau 100 mg / hnub hauv 1 lossis 2 koob tshuaj.

Tawm tsam cov keeb kwm yav dhau los ntawm kev noj tshuaj diuretics hauv siab kawg, nws raug nquahu kom pib kho nrog cov tshuaj Lozarel nrog 25 mg (1/2 tab. 50 mg) 1 zaug / hnub.

Hauv kev mob plawv tsis ua hauj lwm, kev muab tshuaj thawj zaug yog 12,5 mg / hnub, tom qab ntawd txhua lub lim tiam nce ntxiv 2 zaug txog 50 mg / hnub, nyob ntawm seb cov tshuaj tiv thaiv kab mob noj. Thaum siv nyob rau hauv thawj zaug koob tshuaj 12,5 mg, nws raug nquahu kom siv cov ntawv ntau dua nrog cov ntsiab lus qis dua ntawm cov tshuaj nquag (25 mg ntsiav tshuaj nrog kev pheej hmoo).

Hauv hom 2 mob ntshav qab zib mellitus nrog proteinuria (txo qhov kev pheej hmoo ntawm kev tsim hypercreatininemia thiab proteinuria), qhov kev xav pib yog 50 mg 1 zaug / hnub hauv 1 koob tshuaj. Thaum kho, nyob ntawm cov ntshav siab, koj tuaj yeem nce cov tshuaj txhua hnub rau 100 mg rau hauv 1 lossis 2 koob tshuaj.

Thaum siv cov tshuaj Lozarel txhawm rau txhawm rau txo qis kev pheej hmoo ntawm kev mob plawv thiab tuag ntawm cov neeg mob ntshav txhaws thiab sab laug ventricular hypertrophy, qhov kev pib noj tshuaj yog 50 mg 1 zaug / hnub, yog tias tsim nyog, cov koob tshuaj yuav raug nce rau 100 mg / hnub.

Cov neeg mob uas lub raum tsis zoo (CC tsawg dua 20 ml / min), muaj keeb kwm muaj kab mob siab, ua kom lub cev qhuav dej, thaum lub sijhawm lim ntshav, nrog rau cov neeg mob uas muaj hnub nyoog qis dua 75 xyoo, nws raug nquahu kom muab tshuaj rau hauv qis qis qis dua - 25 mg (1/2 tab. 50 mg) 1 zaug / hnub.

Feem ntau, cov kev mob tshwm sim yog mob me me thiab tsis hloov, tsis tas yuav tsum tsis tsum kho.

Cev xeeb tub thiab lactation

Lozarel Plus thaum cev xeeb tub / lactation tsis tau sau tseg.

Thaum siv cov tshuaj hauv II - III trimesters ntawm cev xeeb tub, kev puas tsuaj rau tus me nyuam hauv plab yog qhov ua tau, qee qhov, kev kho mob tuaj yeem ua rau nws tuag tau. Kev pheej hmoo ntawm cov teeb meem hauv qab no hauv tus menyuam tseem nce ntxiv: lub plab jaundice thiab jaundice ntawm tus menyuam mos. Tej zaum leej niam yuav ua kom mob thrombocytopenia. Lozarel Plus yuav tsum tau lawb tawm sai sai tom qab paub meej tias cev xeeb tub.

Thaum ntsuam xyuas cov txiaj ntsig thiab kev pheej hmoo ntawm kev siv Lozarel Plus, cov poj niam laus yuav tsum tau suav tias thiazides raug nthuav tawm hauv cov kua mis, thiab cov ntaub ntawv kev nyab xeeb ntawm losartan tsis tau kawm. Yog tias nws tsim nyog siv Lozarel Plus, kev pub mis niam yuav tsum muaj kev cuam tshuam.

Nrog lub raum tsis ua haujlwm

Hauv cov neeg mob uas mob raum tsis zoo (CC tsawg dua 30 ml / min), kev siv tshuaj yog contraindicated.

Nrog mob raum tsis ua haujlwm (CC 30–50 ml / min), Lozarel Plus yog tus muaj kev ceev faj.

Kev kho cov tshuaj rau thawj zaug rau cov neeg mob uas lub raum tsis ua haujlwm, suav nrog kev lim ntshav, tsis tas yuav tsum ua.

Nrog lub siab ua haujlwm tsis zoo

Rau cov neeg mob uas muaj mob hepatic tsis txaus (raws li Child-Pugh nplai ntau dua 9 ntsiab lus), kev kho nrog cov tshuaj tiv thaiv kab mob sib kis ua ke yog contraindicated.

Nrog cov kab mob mob siab thiab ua kom tsis raug mob hepatic tsawg dua 9 cov qhab nia ntawm Child-Pugh Lozarel Plus, nws tau siv hauv kev saib xyuas mob.

Kev Sib Sau thiab daim ntawv ntawm tso tawm

Cov tshuaj yog muag nyob rau hauv daim ntawv ntawm biconvex, puag ncig ntsiav tshuaj, coated nrog lub plhaub daj lub teeb. Yog tias koj rhuav tshem cov ntsiav tshuaj ua 2 ntu, sab hauv koj tuaj yeem pom cov tub ntxhais kawm dawb lossis dawb-daj. Txhua pob ntawv muaj 30 ntsiav tshuaj.

Raws li cov khoom siv cuam tshuam, cov tshuaj yuav muaj 12,5 mg ntawm hydrochlorothiazide thiab 50 mg ntawm potassium losartan lossis 25 mg ntawm hydrochlorothiazide thiab 100 mg ntawm potassium losartan.

Lub hauv paus tseem ceeb ntawm Lozarel Plus muaj cov lactose monohydrate, pregelatinized hmoov txhuv nplej siab, MCC, colloidal silicon dioxide, magnesium stearate.

Lub plhaub muaj cov xim daj hlau oxide (zas xim), hyprolose, titanium dioxide, hypromellose.

Lozarel: cov lus qhia rau kev siv, nqe, analogues

Lozarel yog ntshav siab txo cov tshuaj noj uas yog siv dav hauv kev kho mob rau cov neeg muaj kev mob ntshav siab, lub plawv tsis ua haujlwm, thiab ntshav qab zib (los tiv thaiv lub raum). Zoo li lwm yam tshuaj, nws muaj qee qhov cim, contraindications thiab cov kev mob tshwm sim.

Cov xwm txheej, qhov ntev cia

Khaws Lozarel Plus nyob rau qhov kub txog +25 degrees rau tsis ntev tshaj ob xyoos.

Rau cov neeg nyob hauv Lavxias ntim cov tshuaj kho tus nqi 200-300 rubles.

Tus nqi kwv yees Lozarel Ntxiv hauv Ukraine - 240 hryvnia.

Cov tshuaj ntawm cov tshuaj yog cov tshuaj xws li Lozartan N, Simartan-N, Lozartan-N Canon, Presartan N, Lorista ND, Lorista N.

Kev txiav txim los ntawm kev txheeb xyuas, Lozarel Plus ua rau txo cov ntshav siab thiab muaj txiaj ntsig zoo rau lub xeev ntawm cov hlab plawv.

Cov kws kho mob hais tias cov tshuaj tsis haum rau txhua tus neeg mob hypertensive, yog li koj yuav tsum tau noj nws raws li kev pom zoo los ntawm tus kws kho mob.

Koj tuaj yeem nyeem cov kev txheeb xyuas sab laug los ntawm cov neeg tiag tiag ntawm qhov kawg ntawm cov lus qhia.

Cov lus qhia rau kev siv

Raws li cov lus qhia rau kev siv, cov tshuaj feem ntau noj ib hnub ib zaug. Thiab lawv ua ob qho tib si ntawm lub plab khoob, thiab tom qab noj mov.

Hauv kev kho kab mob siab tshaj plaws, cov tshuaj thawj thiab tom qab ntawd yog 50 mg ib hnub ib zaug. Nrog cov txiaj ntsig tsis txaus, qhov tshuaj tau nce ntxiv rau 100 mg ib hnub (yog tias xav tau, tuaj yeem faib ua ob zaug).

Hauv kev kho mob ntawm lub plawv tsis ua haujlwm ntev, kev pib tshuaj yog 12,5 mg (ib hlis twg ntawm lub ntsiav tshuaj) ib hnub, tom qab ntawd tau nce ntxiv (qhov ntau npaum li cas yog muab ob npaug rau txhua lub lim tiam). Ntau tshaj 50 mg yuav tsum tsis txhob noj ib hnub.

Txo txoj kev pheej hmoo ntawm kev tsim hypercreatininemia thiab proteinuria hauv cov neeg mob uas muaj ntshav qab zib hom 2, kev kho mob nrog cov tshuaj pib nrog 50 mg ib hnub ib zaug. Tom qab, qhov kev noj tshuaj txhua hnub yog nce (nrog rau cov txiaj ntsig tsis txaus) txog li 100 mg noj hauv ib lossis ob koob.

Txo txoj kev pheej hmoo ntawm kev mob plawv thiab tuag hauv cov neeg muaj mob ntshav siab thiab cov leeg ntawm sab phab ntsa ventricular phab ntsa, txoj kev kho mob tau pib nrog 50 mg ib hnub ib zaug. Yog tias tsim nyog, nce qhov koob rau 100 mg ib hnub twg.

Qhov koob tshuaj qis dua (25 mg rau ib hnub) tau pom zoo rau tib neeg:

dhau 75 xyoo
kev txom nyem los ntawm lub cev qhuav dej, kab mob siab thiab mob raum,
ua rau kev lim ntshav.

Kev txheeb xyuas ntawm Lozarel

“Kuv tau mob plawv tsis zoo li tsib xyoos tas los. Kuv sim yuav luag txhua txhua ACE inhibitors, tab sis yuav luag tsis pom muaj kev hloov pauv zoo. Tom qab ntawd tus kws kho mob tau hais rau kuv Lozarel. Raws li qhov tshuaj tau noj, nws tau pib pom tias nws nkees, tom qab ntawd nws o ntawm nws txhais ceg thiab caj npab poob qis, tom qab ntawd ua tsis taus pa. Cov tshuaj tsis pib tshwm sim tam sim ntawd, tab sis ntev dua koj noj nws, qhov tshwm sim tshwm sim ntau yuav tshwm sim. Tom qab tsib lub hlis ntawm kev noj, Kuv tau tshem tawm ib qho kev tsaus ntuj nti hnoos, thiab tam sim no kuv tuaj yeem khav tau ntawm tus tsis muaj zog thiab o. Tau, thiab txog siav ua pa tsis tshwm "