Gabapentin: muaj pes tsawg leeg thiab siv tshuaj ua yeeb tshuaj

cov tshuaj heev : gabapentin,

1 tshuaj ntsiav muaj 300 mg ntawm gabapentin hais txog 100% anhydrous tshuaj,

Cov muaj tswv yim: microcrystalline cellulose, pob kws nplej siab, talc

tshuaj ntsiav muaj pes tsawg leeg: gelatin, titanium dioxide (E 171).

Nta ntawm cov tshuaj Gabapentin

Tsis ntev los no, cov yeeb tshuaj Gabapentin yog qhov muaj kev txaus siab uas yog siv hauv kev kuaj mob. Thaum pib, nws tau sau npe ua yeeb tshuaj antiepileptic.

Tus qauv tshuaj ntawm cov tshuaj yog gabapentin

Tom qab, lawv pom tias lub peev xwm ntawm cov tshuaj kom nres neuropathic mob tawm tsam thaum mob postherpetic neuralgia, mob polio neuropathy, thiab reflex sympathetic dystrophy.

Cov kev tshawb nrhiav tom qab paub tseeb tias muaj cov tshuaj tua kab mob hauv cov tshuaj, manifested nyob rau hauv kev mob ntshav qab zib neuropathy thiab sympathetic reflex dystrophy. Qhov feem ntau cuam tshuam yog kev siv cov tshuaj Gabapentin los tshem tawm qhov mob neuropathic syndrome ntawm ntau yam etiologies.

Kev sib xyaw thiab daim ntawv

Lub npe kev lag luam yog Gabapentin, cov tshuaj muaj pes tsawg leeg yog gabapentin 300 mg, cov khoom siv ntxiv yog calcium stearate, sodium carboxymethyl hmoov txhuv nplej siab, microcrystalline cellulose. Cov tshuaj ntsiav yog titanium dioxide thiab gelatin.

Cov tshuaj tau tso tawm hauv daim ntawv ntawm cov ntsiav tshuaj lossis tshuaj ntsiav. Cov kaus poom tuaj yeem yog xim dawb, daj lossis ntsuab, nyob ntawm tus neeg tsim khoom tsim.

Gabapentin tshuaj ntsiav tso tawm daim ntawv

Lub gelatin tsiav tshuaj muaj hmoov ntawm lub teeb daj lossis xim dawb. Lub hmoov ua tau zoo-tau zoo, kev tsim muaj cov qa me me, uas, thaum nias nrog cov iav spatula, tuaj yeem tawg ua kom tawg, tuaj yeem lees txais.

Cov tshuaj ntsiav Gabapentin tsuas yog muaj hauv cov ntawv sau tshuaj. Qhov tseeb ntawm cov tshuaj tseem nyob hauv kev ua xyem xyav.

Cov qauv ntawm Gabapentin hauv nws cov tshuaj lom neeg yog zoo ib yam li GABA. Txawm li cas los xij, nws tsis nkag mus rau kev sib txuas lus nrog GABA agonists thiab GABA receptors. Kev sib cuam tshuam ntawm cov tshuaj tshwm sim nrog cov receptors tshiab ua si lub luag haujlwm ntawm qhov txuas hauv cortical neurons.

Thaum lub sijhawm tshawb fawb txog ntawm cov nas, lawv tau pom tias muaj cov protein khi ruaj khov thaj tsam ntawm cov tshuaj, uas qhia txog cov kev ua kom tsis haum thiab anticonvulsant ntawm cov tshuaj nws tus kheej thiab nws cov derivatives. Cov nyhuv anticonvulsant pom tau zoo, nrog kev pab uas nws muaj peev xwm tshem tawm qhov mob ntawm neuropathic xwm ntawm qhov nruab nrab thiab qib nruab nrab.

Nce GABA synthesis hauv lub hauv nruab nrab cov hlab hlwb nrog Gabapentin

Cov tshuaj tiv thaiv analgesic thiab anticonvulsant ntawm cov tshuaj yog ua tau vim yog kev tshem tawm ntawm glutamate-kev tuag ntawm cov hlwb ntawm cov pab pawg neuronal, los ntawm inhibiting cov synthesis ntawm glutamate. Gabapentin muaj peev xwm nce kev sib txuas ntawm gamma-aminobutyric acid nyob rau hauv nruab nrab lub paj hlwb.

Nyob rau tib lub sijhawm, nyob rau hauv kev cuam tshuam ntawm cov tshuaj, kev tso tawm ntawm cov neurotransmitters ntawm cov txiaj ntsig zoo siab yog suppressed. Neuropathic mob yog qhov mob siab los ntawm qhov khi ntawm cov calcium calcium.

Raws li qhov tshwm sim ntawm qhov kev sib txuam no, tus nqi ntawm calcium nkag mus rau hauv cov hlwb poob qis, thiab PD ntawm cov qog ua ntawm cov hlab ntsha cov leeg poob qis. Nyob hauv kev cuam tshuam ntawm Gabapentin, qhov tsis haum ntawm GABA hauv cytoplasm ntawm neurons nce, ntshav serotonin yuav loj dua. Thaum lub cev metabolism, cov tshuaj tawm hauv lub cev los ntawm hemodialysis, los ntawm ob lub raum.

Kev ntsuas rau nkag

Hauv cov lus qhia rau kev siv ntawm Gabapentin, cov ntaub ntawv zoo li no tau qhia:

1. neuropathic mob tawm tsam hauv cov neeg laus hnub nyoog tshaj 18 xyoo (tsis muaj ntaub ntawv qhia txog kev siv tsis muaj mob txog hnub nyoog no),
2. focal seizures nrog lossis tsis muaj kev faib tawm, pib txij hnub nyoog 12 (tsis muaj xov xwm txog kev siv nyab xeeb txog thaum muaj hnub nyoog 12).

Cov tshuaj yog tshuaj raws li kev tawm dag zog thaum kho mob qaug dab peg ib nrab keeb yam tsis muaj qhov dav dav thiab nrog rau kev faib tawm thib ob hauv cov menyuam txij thaum muaj hnub nyoog peb xyoos thiab cov laus.

Kev siv gabapentin kom tshem tawm qhov mob neuropathic

Txog thaum muaj peb xyoos, nws yog qhov nyuaj rau kev txiav txim siab txog kev siv tshuaj - tsis muaj ntaub ntawv qhia txog nws txoj kev nyab xeeb thiab siv tau hauv cov neeg mob zoo li no.

Cov Yuav Tsum Muaj

Gabapentin yog contraindicated nyob rau hauv:

• nrog lub cev tsis zoo ntawm lub cev mus rau cov khoom siv tseem ceeb lossis cov pabcuam pabcuam hauv cov khoom sib xyaw,
• thaum cev xeeb tub thiab lactation,
• hauv thaum yau (txog 8 xyoo).

Kev noj zaub mov noj Gabapentin yog ywj siab ntawm cov sij hawm noj mov. Cov ntsiav tshuaj lossis tshuaj ntsiav tau ntxuav nrog lub qhov dej txaus.

Rau cov hluas thiab cov laus hauv kev kho tus mob chua leeg, 300 mg ntawm cov tshuaj yog kws kho. Txhua txhua hnub, kev noj tshuaj ntawm Gabapentin tau nce ntxiv los ntawm 300 mg txog thaum cov txiaj ntsig xav tau. Qhov txiaj ntsig nruab nrab ntawm txhua hnub yog 1800 mg, rau qee cov neeg mob nws tuaj yeem yog 3600 mg.

Thaum kho cov neeg mob hnub nyoog 8 txog 12 xyoos, noj tshuaj ntau yog xam raws qhov hnyav hauv lub cev - 10-15 mg / kg / hnub. Hauv peb hnub tom ntej no, cov tshuaj no tau muab hloov kho txog 30 mg, muab faib ua peb ntu ib hnub.

Muaj lwm txoj hauv kev rau kev siv tshuaj:

1. lub cev hnyav 26-36 kg - 900 mg,
2. 37-50 kg - 1200 mg,
3. ntau tshaj 50 kg - 1800 mg.

Kev kho mob ntawm qhov mob ntawm neuropathic xwm cuam tshuam nrog kev siv qhov tsawg kawg nkaus ntawm 300 mg rau ib hnub, nrog kev niaj hnub nce ntxiv hauv qhov nyiaj txog 1800 mg. Tus nqi no yuav tsum tau muab faib ua peb koob.

Noj 300 mg ntawm gabapentin ib hnub rau mob neuropathic

300-400 mg thaum pib kho yog kho rau cov neeg mob uas pheej xav tau kev kho mob hemodialysis. Lub hom phiaj yog los ntub lub cev nrog tshuaj.

Tom qab, ib qho sijhawm nruab nrab ntawm 4 teev mus txuas ntxiv yuav tsum tau noj 200-300 mg. Qhov koob tshuaj txhua hnub hauv cov neeg mob uas muaj qhov tsis txaus siab nyob rau hauv qhov txheej txheem excretory nyob ntawm qib QC.

Noj ntau dhau

Nyob rau hauv rooj plaub ntawm kev kwv yees cov kev ua kom tsawg ntawm cov tshuaj ntau dua, qaug zog, diplopia, dysarthria, kiv taub hau tshwm sim. Hauv qee kis, tsis nco qab zoo.

Qaug zog vim tias dhau hwv ntawm Gabapentin

Raws li cov lus qhia, cov tshuaj yuav tsum tsis ua rau tus tsos mob thim tawm. Kev tshuaj xyuas cov neeg mob txog Gabapentin qhia tau hais tias qee qhov muaj qhov tsis zoo ntawm kev saib xyuas zoo tom qab kev ncua tsis pub nkag mus.

Hauv chaw muag tshuaj, lwm yam tshuaj tsim tawm, Gabapentin analogues - Tebantin, Konvalis, Neurontin, Gapentek, Lepsitin.

Cov tshuaj sib dhos ntawm cov tshuaj Gabapentin

Qhov cuam tshuam ntawm tag nrho cov tshuaj no yog tias lawv muaj gabapentin.

Tshuaj los tsis

Cov neeg sawv cev Gabapentin muaj nrog rau cov tshuaj uas ua rau kev quav yeeb quav tshuaj. Coob leej xav tias gabapentin yog yeeb tshuaj.

Ntawm cov kws tshaj lij, muaj lub tswv yim hais txog qhov phom sij ntawm cov tshuaj - nws tuaj yeem ua rau muaj kev cuam tshuam ntawm kev nyuaj siab thiab cuam tshuam rau cov tsos ntawm kev xav tua tus kheej. Cov lus qhia nom piav qhia txhua qhov kev pheej hmoo, yog li lawv tsis pom zoo kom siv cov tshuaj ntawm lawv tus kheej.

Kev phom sij ntawm kev siv tshuaj yaj yeeb nyob rau hauv qhov zoo li ntawm qhov tseeb ntawm tshem tawm cov tsos mob tshem tawm. Qhov no qhia nws txoj kev ua haujlwm muaj zog thiab tsis zoo rau tib neeg lub cev. Nws yuav tsum nco ntsoov tias txhua yam tshuaj uas suav nrog gabapentin yuav tsum yog tus kws kho mob paub tab thiab paub dhau los.

Tus kws tshaj lij yav dhau los ua tib zoo kawm txog tus neeg mob lub keeb kwm, thiab tsuas yog tom qab ntawd kos kev txiav txim siab txog kev teem caij. Txwv tsis pub, tus neeg mob tuaj yeem yuav muaj kev tsis txaus, ua tus hais lus tsis meej thiab ua kom nws tus kheej nyiam.

Kev kho mob nrog cov tshuaj no rau kev haus dej cawv lossis tshuaj yeeb dej cawv tsis yog tsim nyog - tawm tsam keeb kwm ntawm ib tus quav, qhov tshiab yuav tshwm sim. Rau cov kev mob tshwm sim ntawm cov mob tshwm sim, koj yuav tsum nrhiav kev pab ntawm kws kho mob sai.

Pharmacological pawg

PBX code N03A X12.

Tshuaj qaug dab peg Raws li monotherapy nyob rau hauv kev kho mob ntawm ib nrab convulsive chua leeg nrog lossis tsis muaj theem nrab dav dav hauv cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos.

Raws li ib qho kev kho ntxiv hauv kev kho mob ib nrab ntawm qhov mob chua leeg nrog lossis tsis muaj theem nrab dav dav hauv cov neeg laus thiab menyuam yaus txij li 6 xyoo.

Kev kho mob ntawm qhov pheej mob neurological nrog postherpetic neuralgia lossis ntshav qab zib neuralgia hauv cov neeg laus.

Tsuas tshuaj thiab tswj hwm

Sab hauv, tsis hais txog pluas noj, muaj dej ntau.

Thaum pib kho mob, txoj haujlwm titration uas pom hauv Table 1 tau pom zoo rau cov neeg laus thiab menyuam yaus hnub nyoog dhau 12 xyoos.

Cov neeg mob qaug dab peg yuav tsum tau kho mus sij hawm ntev. Kev noj tshuaj yog txiav txim siab raws li kev pom zoo ntawm ib leeg thiab txiaj ntsig ntawm cov tshuaj. Thaum, raws li kws kho mob, muaj qhov xav txo qis qhov tshuaj, txiav tawm cov tshuaj lossis hloov nws nrog lwm tus neeg sawv cev, qhov no yuav tsum tau ua maj mam dhau ib zaug ntawm tsawg kawg ib lub lis piam.

Cov neeg loj thiab me nyuam muaj 12 xyoos rov saud.

Kev siv tshuaj ntawm Gabantin yog 900-3600 mg ib hnub (muab faib ua 3 koob tshuaj).

Kev kho mob tuaj yeem pib nrog titration ntawm koob tshuaj, raws li tau piav qhia hauv lub rooj 1, lossis 300 mg raws li tau hais tseg peb zaug nyob rau hnub 1. Yav tom ntej, nyob ntawm qhov kev teb ntawm tus neeg mob rau kev kho mob thiab kev tiv taus tshuaj, qhov koob tshuaj tuaj yeem raug maj mam nce los ntawm 300 mg rau ib hnub txhua 2-3 hnub rau qhov siab tshaj plaws ntawm 3600 mg ib hnub. Txog rau qee tus neeg mob, yuav tsum tau muaj qee qhov ntsuas qeeb qeeb ntawm gabapentin ntxiv. Lub sijhawm tsawg kawg nkaus ua ntej ncav lub koob tshuaj 1800 mg rau ib hnub sib npaug rau ib lub lis piam, koob tshuaj 2400 mg rau ib hnub - 2 lub lis piam, koob tshuaj 3600 mg ib hnub - qhov nruab nrab li ntawm 3 lub lis piam. Qhov siab tshaj plaws rau kev sib koom tes ntawm cov koob tshuaj yuav tsum tsis pub tshaj 12:00 los tiv thaiv kev txhim kho ntawm qaug dab peg.

Cov menyuam hnub nyoog 6 txog 12 xyoos.

Txoj kev kho mob pib nrog ib koob tshuaj 10-15 mg / kg / hnub. Kev siv tshuaj zoo yog 25-35 mg / kg / hnub, ua tiav los ntawm kev lees paub rau thaj tsam li 3 hnub. Qhov koob tshuaj txhua hnub tau muab faib ua peb koob, qhov siab tshaj plaws tawg nruab nrab ntawm cov koob tshuaj yuav tsum tsis pub tshaj 12:00.

Neuropathic mob rau cov neeg laus.

Kev kho mob tuaj yeem pib los ntawm ib feem kaum ntawm koob tshuaj, raws li tau piav qhia hauv lub rooj 1, lossis los ntawm kev sau ntawv ntawm thawj koob tshuaj 900 mg ib hnub, muab faib ua peb koob. Yav tom ntej, nyob ntawm qhov kev teb ntawm tus neeg mob rau kev kho mob thiab kev tiv taus tshuaj, qhov koob tshuaj tuaj yeem raug maj mam nce los ntawm 300 mg rau ib hnub txhua 2-3 hnub rau qhov siab tshaj plaws ntawm 3600 mg ib hnub.

Txog rau qee tus neeg mob, yuav tsum tau muaj qee qhov ntsuas qeeb qeeb ntawm gabapentin ntxiv. Lub sijhawm tsawg kawg nkaus kom ncav cuag ib koob tshuaj 1800 mg rau ib hnub sib npaug rau ib lub lis piam, koob tshuaj 2400 mg rau ib hnub - nws siv 2 lub lis piam, txhaj tshuaj 3600 mg ib hnub - qhov nruab nrab li ntawm 3 lub lis piam. Qhov siab tshaj plaws rau kev sib kis ntawm cov koob tshuaj yuav tsum tsis pub tshaj 12:00.

Kev nyab xeeb ntawm kev kho mob ntev tshaj li 5 lub hlis nyob rau hauv kev kho mob ntawm kev mob peripheral neuropathic tsis tau kawm. Yog tias nws yuav tsum tau siv cov gabapentin hauv kev kho mob ntawm cov leeg mob neuropathic rau ntau dua 5 lub hlis, tus kws kho mob yuav tsum soj ntsuam kev mob ntawm tus neeg mob thiab txiav txim siab qhov kev kho mob ntxiv.

Yog tias dhau kev siv tshuaj ntxiv, yuav tsum tsis txhob noj, muab hais tias yuav tau txais koob tshuaj txuas ntxiv tsis pub dhau lub sijhawm tom qab 4:00. Txwv tsis pub, cov koob tshuaj tsis tas yuav tsum tsis txhob ua.

Rau cov neeg mob uas lub cev tsis muaj zog txaus, nrog rau lub cev qis, tom qab hloov khoom nruab nrog, gabapentin yuav tsum tau titrated qeeb dua los ntawm kev siv daim ntawv tshuaj nrog cov tshuaj tsawg dua los yog los ntawm kev ncua sij hawm nruab nrab ntawm nce qhov koob tshuaj.

Cov neeg laus laus (tshaj 65 xyoos).

Rau cov neeg mob laus, yuav tsum tau hloov koob tshuaj vim tias lub hnub nyoog ntawm lub raum tsis zoo ua haujlwm (saib Cov Lus 2).

Cov neeg mob uas lub raum tsis ua hauj lwm zoo.

Hauv cov neeg mob uas lub raum tsis ua haujlwm lossis cov uas mob hemodialysis, pom zoo koob tshuaj pom zoo raws li piav qhia hauv Daim Ntawv 2.

Cov pab pawg tshuaj, INN, thaj tsam

Gabapentin belongs rau cov chaw muag tshuaj ntawm cov tshuaj anticonvulsants thiab antiepileptic. Lub npe thoob ntiaj teb nonproprietary tshuaj (INN) yog Gabapentin.

Cov tshuaj yog siv nyob rau hauv ntau yam ntawm cov tshuaj:

• nyob rau hauv neurology rau kev kho mob ntawm kev mob vwm thiab mob hlwb hauv cov laus thiab cov menyuam yaus,
• nyob rau hauv kev kho mob thiab dermatovenerology kom tshem tawm kev mob nrog rau mob yuag thiab mob ntsig txog kev puas tsuaj rau cov pob txha caj qaum.

Cov ntawv thiab cov nqi kwv yees

Gabapentin tsiav tshuaj muaj nyob rau hauv pob ntawm 10 txog 100 tej daim. Sab nraud, cov tsiav tshuaj muaj peev xwm muaj xim los ntawm dawb-daj mus rau lub teeb ntsuab, sab hauv cov hmoov yog dawb.

Tus nqi ntawm gabapentin sib txawv nyob ntawm seb muaj pes tsawg ntawm cov ntsiav tshuaj hauv pob.

Cheebtsam

Cov tshuaj muaj pes tsawg leeg suav nrog kev ua haujlwm tseem ceeb thiab cov khoom siv pabcuam:

Pharmacodynamics thiab pharmacokinetics

Gabapentin yog ib qho piv txwv ntawm cov neurotransmitter inhibitor gamma-aminobutyric acid, cov nyhuv ntawm daim ntawv thov zoo ib yam li tranquilizers thiab tshuaj tiv thaiv kev puas tsuaj, tab sis cov mechanism ntawm kev ua yog txawv. Cov tshuaj yeeb dej caw tsis cuam tshuam rau qhov uptake thiab receptors rhiab rau GABA. Cov kev soj ntsuam tseem ceeb yog vim qhov tseeb tias gabapentin khi rau qhov muaj cov calcium uas muaj cov kav dej ntau thiab tiv thaiv kev nkag rau ntawm calcium uas muaj kev cuam tshuam nrog kev cuam tshuam ntawm qhov mob impulse.

Tus txheej txheem ntawm kev ua ntawm Gabapentin

Gabapentin nkag tau dawb nkag mus rau cov ntaub so ntswg ntawm lub hlwb thiab txwv tsis pub muaj kev ua kom tsis taus, tiv thaiv kev loj hlob ntawm qaug dab peg los ntawm kev noj tshuaj thiab cov hluav taws xob tawm ntawm sab nraud, kab mob rau cov kab mob, thaum tawm hws los ntawm kev mob qog nqaij hlav. Nyob rau tib lub sijhawm, lub tshuab ntawm cov nyhuv anticonvulsant tsis tau ua tib zoo kawm, uas nws txwv qhov ntau ntawm cov cim qhia rau kev tswj hwm ntawm cov tshuaj no.

Lub bioavailability ntawm cov tshuaj nquag yog 60%, qhov pib ntawm kev sib txuas lus nrog cov ntshav plasma protein tsawg dua 3%, tab sis bioavailability tsis muaj feem cuam tshuam nrog koob tshuaj, txij li nrog kev nce ntxiv ntawm cov tshuaj yeeb dej caw, Gabapentin txoj haujlwm txo qis.

Nrog kev tswj hwm ntawm qhov ncauj, qhov ntau tshaj plaws ntawm cov tshuaj tau txiav txim siab hauv ntshav tom qab ob mus rau peb teev, thiab ib nrab lub neej yog 5-7 teev. Nws yog tsuas yog nrog cov zis, thaum nws tsis tiav hauv tib neeg lub cev thiab tsis koom nrog hauv cov kev ua haujlwm hauv oxidative, kev hloov pauv thiab kev lim dej hauv lub siab tsis tshwm sim.

Yuav hloov cov tshuaj li cas?

Hauv cov khw muag tshuaj, cov tshuaj sib txig sib xyaw ntawm cov tshuaj tau nthuav tawm, uas suav nrog kev sib txuam, thiab cov tshuaj muaj qhov zoo sib xws. Lawv txawv hauv nqe thiab daim ntawv tso tawm.

Kev taw qhia thiab kev txwv

Qhov tshuaj dab tsi pab? Nws yog ib qho tsim nyog kom nkag siab meej txog lub hauv paus ntsiab lus ntawm kev ua yeeb tshuaj thiab txiav txim xyuas qhov ntsuas rau kev siv ntawm cov tshuaj no:

• siv raws li kev kho mob monotherapy hauv cov neeg mob uas muaj 12 xyoos rov hauv, muaj cov qaug dab peg ib nrab, nrog rau kev txiav txim siab dav dav ntawm cov kab mob,
• neuropathic mob rau cov neeg laus
• siv cov tshuaj tiv thaiv tsis zoo ntawm hom mob vwm,
• tshem tawm cov mob tom qab kev txom nyem.

Cov tshuaj muaj nruj contraindications, nyob rau hauv kev sib txuas nrog lub zog muaj zog, thiab yog ua tib zoo siv nyob rau hauv cov ntaub ntawv ntawm kev ua txhaum ntawm sab hauv plab hnyuv siab raum, neurological pathology.

Ntawm cov kev txwv rau kev noj tshuaj, nws tsim nyog rau lub ntsiab lus:

• tus kheej tsis kam lees thiab ua siab phem rau cov feem uas ua yeeb tshuaj,
• mob o nyob rau hauv lub cev txuam nrog malfunction ntawm endocrine qog (pancreatitis, malfunction ntawm lub qog gland, pancreatic necrosis, pathology ntawm adrenal cortex),
• tshuaj thiab mob siab daim siab puas, kab mob sib kis ntawm tus kab mob biliary (mob ntsws, mob siab tsis ua haujlwm, mob siab B thiab C),
• mob raum tsis ua haujlwm, nrog rau ua raws li cov txheej txheem ntawm cov khoom cua lim - hemodialysis,
• lub sij hawm ntawm cev xeeb tub, txij li tsis muaj ib qho pov thawj nyob rau ntawm kev cuam tshuam ntawm tus me nyuam hauv plab. Hauv qhov xwm txheej uas muaj txiaj ntsig rau kev noj qab haus huv thiab lub neej ntawm leej niam ntau dua qhov kev pheej hmoo ntawm kev ua mob rau lub cev hauv plab, Gabapentin tau raug tshuaj tom qab sab laj nrog kws kho mob uas cev xeeb tub nrog tus poj niam,
• lub sij hawm pub niam mis, txij li tsis muaj ntaub ntawv qhia txog cov txheej txheem ntawm kev kis rau menyuam. Hauv cov txheej txheem ntawm kev kawm txog cov tshuaj, nws tau ua pov thawj tias cov tshuaj ua kom dawb nkag rau hauv niam mis,
• cov neeg nyob rau hauv 12 xyoo rau lub hnub nyoog rau kev kho mob ntawm kev txawj npaj txhij,
• qhov mob nyob hauv thaj chaw lumbar tom qab herpetic tawg ntawm tus mob pob ntseg thaum muaj hnub nyoog qis dua 18 xyoo.

Koob tshuaj rau cov neeg laus thiab cov me nyuam

Daim ntawv qhia cov tshuaj ntau npaum li cas nyob ntawm qhov xwm txheej etiological thiab kev tshwm sim ntawm pathology. Cov hauv paus ntsiab lus rau kev xam cov koob tshuaj tau qhia hauv lub rooj.

Cov tshuaj tsis raug txwv rau cov menyuam yaus hnub nyoog qis dua 12 xyoos nrog rau kev qaug dab peg, koob tshuaj thawj zaug rau menyuam yaus tsis txawv qhov ntawd ntawm cov neeg laus - 900 mg hauv peb koob tshuaj, tab sis qhov ntau tshaj - 2400 mg hauv peb faib 3 koob (3600 mg tom qab 18 xyoo).

Txog kev kho mob quav cawv

Cov kev tshawb fawb nrog cov pab pawg tswj tau pom tias cov neeg mob uas tau siv lub sij hawm ntawm kev kho mob rau 3 lub hlis los kho kev quav dej cawv tau ceeb toom txo qis ntawm kev nqhis dej rau cov dej cawv uas muaj cawv thiab muaj kev ruaj khov ntawm lawv lub hlwb (noj ib koob tshuaj 300 mg peb zaug ib hnub).

Nrog rau qhov nce ntxiv ntawm koob tshuaj rau 600 mg peb zaug hauv ib hnub, tsis tsuas yog tsis muaj kev nqhis dej haus cawv, tab sis kuj tseem ib txwm pw tsaug zog, 46% tau tso tseg tsis haus cawv, thiab lub xeev ntawm kev puas siab puas ntsws zoo dua los ntawm 15% (txo qis kev nyuaj siab, chim siab, kev tawm tsam).

Gebapentin nquag pab tua cov quav cawv.

Yuav ua li cas kom thim cov tshuaj?

Cov tshuaj yog txwv tsis pub tshem tawm sai sai, qhov pom ntawm lub syndrome ntawm kev tshem tawm thiab kev loj hlob ntawm cov teeb meem los ntawm cov leeg kho mob yog tus yam ntxwv - los ntawm kev ntxhov siab, kev ntxhov siab, kev hloov pauv mus pw, insomnia mus rau lub ntsej muag pom kev tsis meej thiab kev loj hlob ntawm cov xwm txheej tshwm sim.

Qhov zoo tshaj plaws ntawm kev daws teeb meem yog maj mam txo cov tshuaj ntau dua 7-10 hnub, ntawm cov koob tshuaj siab thiab siv ntev ntev rau ob peb xyoos, txoj kev tshem tawm txoj kev tuaj yeem ua rau ntau lub hlis kom txog thaum cov tshuaj ntsiav tau txiav tawm.

Muaj cov tshuaj tsis haum thiab noj tshaj

Thaum ua txhaum ntawm kev haus tshuaj ntau npaum li cas, kev noj tshuaj rau tus kheej, kev noj tshuaj ib leeg rau kev haus tshuaj thiab cov khoom siv tsis zoo, kev phiv tshuaj los ntawm cov kab ke sab hauv ntawm lub cev yuav tshwm sim:

Kev noj tshuaj ntau dhau ntawm cov tshuaj pom thaum lub koob pom zoo pom zoo dhau thiab ua rau pom los ntawm cov duab hauv qab no:

• cerebralgia,
• ob lub zeem muag
• lub plab zom mov tsis haum (ntuav, raws plab),
• cov tsos mob neurological (nkees nkees, hnov ​​ntxhias, tsis hnov ​​lus, hnov ​​qab, tsis nco qab)
• disorientation nyob rau hauv chaw thiab sijhawm.

Txoj kev kho mob pib nrog kev mob plab thiab tso tawm cov tsos mob, cov tshuaj tiv thaiv kab mob tsis muaj tiag. Tus neeg mob xa mus rau lub tsev kho mob kom kho tus mob thiab saib xyuas lub xeev kev noj qab haus huv.

Puas yog nws puas muaj kev txiav luam yeeb?

Cov tshuaj tsis tsim cov tshuaj yeeb, vim tias cov mechanism ntawm kev txiav txim ntawm lub cev yog qhov txawv ntawm qhov kev xav ntawm opioid receptors. Nws tsis ua rau qhov kev xav zoo siab, tab sis tsim cov nyhuv analgesic.

Ib qhov tshwj xeeb ntawm Gabapentin yog tias nrog qhov nce hauv koob tshuaj, qhov ua tau zoo, ntawm qhov tsis sib thooj, poob qis.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj yuav tsum tau siv kom zoo nrog lwm cov tshuaj thiab coj mus rau hauv cov txiaj ntsig ntawm kev cuam tshuam:

1. Morphine thiab narcotic analgesics - tsis muaj kev cuam tshuam rau ib leeg, qhov sib piv nruab nrab yam tsis muaj kev txwv lossis nthuav dav ntawm cov nyhuv ntawm kev siv ntawm ob cov tshuaj ib txhij.
2. Kev nkag nrog antacids inhibits qhov kev txiav txim ntawm Gabapentin los ntawm 15-30%.
3. Kev txo qis hauv lub raum tsis ua haujlwm ntawm cov tshuaj yog pom thaum ua ke nrog cov tshuaj uas suav nrog cimetidine.

Cov lus qhia tshwj xeeb

Siv nrog ceev faj nyob rau hauv muaj cov txheej txheem inflammatory nyob rau hauv lub cev, nrog ib tug inflammatory kev tiv thaiv ntawm tus txiav, nws yog tsim nyog maj mam txiav cov tshuaj nyob rau hauv kom tsis txhob aggravation ntawm tus mob thiab provocation ntawm qaug dab peg.

Gabapentin tsis yog siv rau kev kho mob ntawm tus mob vwm vwm. Nyob rau lub sijhawm kho, qee qhov kev ua yuav tsum raug zam: tsav tsheb, tshwj xeeb tshaj yog thaum ua haujlwm nrog pej xeem thauj, thiab txwv kev ua haujlwm nrog cov tshuaj yeeb yaj kiab thiab yuav tsum muaj kev kub siab ntev, vim tias qhov tshuaj tiv thaiv tus nqi yuav txo qis nrog qhov tseem ceeb ntawm cov txheej txheem inhibition hauv cerebral cortex.

Kev tshuaj xyuas ntawm cov kws tshaj lij thiab cov neeg mob

Kev tshuaj xyuas ntawm cov kws kho mob hais txog Gabapentin yog qhov zoo heev, cov ntawv kho mob nquag yog sib npaug rau theem ntawm kev ua tau zoo hauv kev kho mob los ntawm kev mob tshwm sim.

Kev tshuaj xyuas ntawm cov neeg mob uas coj Gabapentin rau kev daws qhov mob neuropathic feem ntau yog qhov tsis zoo, cov neeg mob nco txog kev phiv los ntawm kev noj cov ntsiav tshuaj Gabapentin los ntawm kev mob plab thiab lub paj hlwb tsis zoo, thiab kev quav dej quav cawv tseem tseem tau sau tseg. Tom qab qhov kawg ntawm kev kawm ntawm kev kho, kev hloov pauv ntawm qhov zoo ntawm kev pw tsaug zog, kev ntxhov siab thiab pheej tsaug zog tas li tau sau tseg.

Igor, 31 xyoo: “Qhov quav tau pib tiag tiag, nws tseem nyuaj rau noj tsis tas yuav noj ntxiv, yog li xav. Kuv muaj teeb meem uas kuv tsis tuaj yeem tsis kam noj tshuaj, Kuv yeej tsis nco nws - nws zoo li hom tshuaj.

Kuv qhov tshuaj ntau ntau nyob rau ntawm 400 mg peb zaug ib hnub twg rau xyoo plaub. Tam sim no kuv pom tias kuv muaj kev nyuaj siab thiab xav tua tus kheej hauv kuv lub taub hau. Xav yog vwm, qhov kev xav tias kuv twb tau ploj kuv lub siab thiab ib tus neeg xav rau kuv. Tam sim no txog sijhawm rau kws kho mob tau txais kev puas siab puas ntsws. ”

Gabapentin yog cov tshuaj zoo rau tshem tawm cov kev mob tshwm sim, txwv tsis pub mob neuropathic thiab tiv thaiv kev qaug dab peg. Ua raws li cov cai ntawm kev coj noj coj ua thiab kev noj tshuaj, nws muaj peev xwm ua tiav qhov kev tshem tawm ntawm cov kab mob ntawm cov leeg hlwb tsis muaj kev cuam tshuam thiab cuam tshuam ntawm ib feem ntawm lub cev.