Augmentin® (Augmentin®)
Augmentin yog ib cov tshuaj uas nyuaj heev los ntawm cov pab pawg ntawm cov tshuaj tua kab mob nrog cov kev pom ntawm ntau yam, uas suav nrog amoxicillin thiab clavulanic acid.
Lub hauv paus tseem ceeb ntawm cov ntsiav tshuaj yog amoxicillin, uas belongs rau cov tshuaj tua kab mob nrog kev pom dav ntawm cov khoom siv semisynthetic, uas ua kom pom cov kev ua haujlwm siab tiv thaiv feem ntau cov kab mob gram-positive thiab gram-tsis zoo. Amoxicillin raug pov tseg los ntawm beta-lactamases, yog li ntawd, ib cov tshuaj raws li cov tshuaj yeeb yam no tsis yog kws kho rau kev puas tsuaj ntawm cov kab mob pathogenic uas tsim cov beta-lactamases.
Clavulanic acid, uas yog ib feem ntawm cov ntsiav tshuaj ntawm cov tshuaj no, yog ib qho beta-lactam compound uas tuaj yeem rhuav tshem lossis tso tseg qhov kev ua ntawm beta-lactamases thiab lwm yam tshuaj uas tsim los ntawm pathogenic microorganisms, uas nyob rau hauv lem qhia tawm tsam rau penicillin pawg ntawm cov tshuaj thiab cephalosporins.
Qhov clavulanic acid nyob rau hauv cov ntsiav tshuaj tiv thaiv amoxicillin los ntawm kev ua kom tuag ntawm beta-lactamases ua los ntawm cov kab mob me me, yog li pab txhawb kev nthuav tawm ntawm cov tshuaj tua kab mob. Ua tsaug rau cov khoom tivthaiv no, Augmentin tuaj yeem muaj kev cuam tshuam tsis zoo ntawm cov kab mob pathogenic uas muaj peev xwm tiv taus penicillin pab pawg ntawm cov tshuaj thiab cephalosporins.
Cov kab mob dab tsi cuam tshuam los ntawm cov tshuaj no?
Augmentin ntsiav tshuaj nquag tawm tsam gram-zoo thiab gram-tsis zoo aerobic thiab anaerobic pathogens, ntxiv rau cov tshuaj nquag ntawm cov tshuaj cuam tshuam rau qee lwm yam kev ua rau ua rau mob hnyav.
Cov tshuaj tso tawm ntau cov kev ua tawm tsam chlamydia, daj ntseg treponema (tus neeg sawv cev ntawm tus mob syphilis), cov kab mob ua rau kev txhim kho mob leptospirosis, colic Escherichia, staphylococci, streptococci, Klebsiella, listeria, bacilli, clostridia, brucellarlamellella, paum, lwm yam cov kab mob me me.
Qee yam ntawm cov kab mob no ua cov beta-lactamases, uas ua rau lub zog ntawm cov pathogens rau cov tshuaj nquag ntawm cov tshuaj.
Cov chaw muag tshuaj
Cov tshuaj ntsiav Augmentin yog ib qho tshuaj (siv los ua ntev), uas nws txawv txav los ntawm lwm yam tshuaj raws li amoxicillin. Vim tias qhov no, tshuaj yuav siv tau los rhuav tshem cov kab mob ntsws uas tiv taus rau penicillins.
Tom qab noj, cov tshuaj lom neeg nquag ntawm augmentin - amoxicillin thiab clavulanic acid, sai sai thiab ua kom haum rau txoj hnyuv plab. Qhov siab tshaj plaws ntawm kev kho mob ntawm cov tshuaj tau tshwm sim yog tias tus neeg mob noj tshuaj ua ntej noj mov. Qhov tsom ntawm cov tshuaj nquag ntawm cov tshuaj yog tusyees faib thoob plaws lub nruab nrog sab hauv thiab cov tshuab - lub hauv siab hauv lub plab, lub plab hauv plab, cov ntaub so ntswg, nkag mus rau hauv cov kua tsib, muaj nyob hauv cov hnoos qeev, purulent paug, interstitial thiab kua dej hauv qhov quav.
Ib yam li penicillins feem ntau, amoxicillin tuaj yeem sib kis mus rau niam mis tau. Raws li kev tshawb fawb kho mob, ib co kab ntawm clavulanic acid kuj tau teev npe nyob hauv niam cov kua mis. Cov tshuaj no, raws li txoj cai, tsis yog tsim rau kev kho mob rau cov pojniam ua tub rog vim tias nws muaj qhov pheej hmoo ntau ntxiv ntawm cov khoom xyaw nquag ntawm Augmentin hauv lub siab ntawm tus menyuam, uas nkag rau nws lub cev nrog rau niam mis.
Augmentin tseem raug rau kev sim hauv chaw kuaj tsiaj hauv cov tsiaj, thaum lub sijhawm nws tau pom tias clavulanic acid thiab amoxicillin yooj yim nkag mus rau hauv qhov chaw tiv thaiv rau hauv lub tsev menyuam, txawm li cas los xij, kev tshawb fawb tsis qhia tawm ib yam dab tsi hloov pauv ntawm cov tshuaj ntawm cov menyuam hauv plab.
Amoxicillin ua tawm los ntawm tus neeg mob lub cev ib txwm dhau los ntawm ob lub raum, thiab clavulanic acid los ntawm kev ua kom lub raum thiab cov kev ua haujlwm ntxiv. Kwv yees li 1/10 ntawm kev pib siv tshuaj amoxicillin raug tso tawm hauv cov zis, thaum clavulanic acid yauv ua rau cov txheej txheem metabolic thiab qee tawm hauv cov quav thiab tso zis.
Thaum twg Augmentin kho?
Cov cim tseem ceeb rau kev teem sijhawm Augmentin ntsiav tshuaj yog:
- cov kab mob ntawm cov pa hauv siab thiab nasopharynx ntawm cov mob thiab mob hauv keeb - sinusitis, mob rau hauv nruab nrab pob ntseg, mob ntawm lub pharyngeal tonsils, pharyngitis, mob txha caj qaum los ntawm pathogenic microorganisms (streptococci, staphylococci) rhiab rau qhov tshuaj ntawm lub Cheebtsam,
- Kev kis mob thiab mob ntawm cov pa hauv nruab nrog qis - rov qab mob ntsws ntev, mob ntsws, mob ntsws, mob ua rau mob ntsws ntawm cov nqaij mos,
- Cov kab mob sib kis ntawm cov kab mob genitourinary los ntawm hom kab mob ntawm tsev neeg cov kab mob Enterobacteria coli Escherichia, staphylococcus saprophyticus, enterococci, gonococci - cov txheej txheem ua paug ntawm lub zais zis, ua rau mob thiab kis ntawm cov hlab ntsha, ua mob rau cov hlab raum (interstitial nephritis, pyelonephritis, gonadritis)
- Pustular kab mob ntawm daim tawv nqaij - pyoderma, rwj, carbuncles thiab lwm yam mob,
- Kev kis mob ntawm pob qij txha thiab pob txha - txha osteomyelitis los ntawm tsev neeg staphylococcus,
- Teeb meem tom qab yug me nyuam nyuaj los yog rho menyuam yog endometritis, salpingoophoritis, thiab lwm yam kab mob ntawm poj niam kev muaj me nyuam, ua rau los ntawm kev nkag mus ntawm cov kab mob pathogens rau hauv lub cev. Feem ntau, mob kab mob ntawm lub tsev menyuam thiab nws qhov tshwm sim tuaj yeem tshwm sim los ntawm qhov ua tsis ncaj ncees rau kev kuaj mob - keeb kwm kev kuaj mob, lub suab ntawm lub suab, kev kho mob tawm ntawm lub tsev menyuam kab noj hniav, txiav tawm ntawm kev xeeb tub, thiab lwm yam.
Ib qho ntawm cov cim qhia rau kev teem caij ntawm Augmentin ntsiav tshuaj tseem yog sib xyaw ua ke mob plab yog ib feem ntawm kev kho mob nyuaj nrog lwm yam tshuaj.
Txoj kev siv thiab ua li cas ntawm cov tshuaj
Cov chav kawm ntawm kev kho mob thiab kev noj tshuaj ntawm Augmentin ntsiav tshuaj tau tsim los ntawm kws kho mob zoo rau txhua tus neeg mob ib leeg zuj zus. Nws yog ib qho tseem ceeb kom nco ntsoov tias cov tshuaj no yog cov tshuaj tiv thaiv, yog li ntawd, txawm li cas los xij, zoo li lwm yam tshuaj, koj tuaj yeem tsis noj yam tsis muaj kev tso cai thiab thaum koj xav tau! Tsis tas li ntawd, qee qhov kab mob yog tshwm sim los ntawm cov kab mob me me uas tsis cuam tshuam los ntawm cov khoom xyaw nquag ntawm cov ntsiav tshuaj, piv txwv li, kab mob lossis fungi.
Qhov ntau thiab tsawg ntawm cov tshuaj tau txiav txim los ntawm tus kws tshaj lij nyob ntawm ntau yam: tus neeg mob lub hnub nyoog, nws txoj kev kuaj mob, qhov tshwm sim ntawm cov teeb meem, kev ua haujlwm ntawm tus neeg mob lub raum thiab mob siab, lub cev nyhav thiab cov kab ntsig sib cuam tshuam.
Txhawm rau kom ua tiav qhov siab tshaj plaws ntawm kev haus tshuaj thiab txo cov kev pheej hmoo ntawm phiv, Augmentin ntsiav tshuaj raug pom zoo kom noj thaum pib noj mov.
Yam tsawg kawg kiag ntawm txoj kev kho nrog cov tshuaj no yog tsawg kawg 5 hnub. Txawm hais tias tag nrho cov tsos mob ntawm tus kab mob tau ploj mus, thiab tus neeg mob tau hnov zoo, tsis muaj ib qho twg yuav tsum tsis txhob cia koj tus kheej tsis kho kho yam tsis ua tiav txoj kev qhia los ntawm tus kws kho mob. Qhov yog tias cov kab mob pathogenic hloov kho sai sai rau cov tshuaj thiab yog tias tus neeg mob tsis tuaj yeem cuam tshuam txoj kev kho, tom qab ntawd cov tsos mob ntawm tus kab mob tuaj yeem rov qab nrog kev kho dua tshiab. Hauv qhov no, tib lub pathogogogens yuav tsis nkag rau Augmentin ntsiav tshuaj ntxiv lawm, thiab tus kws kho mob yuav tau khaws tej yam tshiab thiab muaj zog ntxiv. Qhov no nyeg ua rau muaj kev pheej hmoo ntawm kev phiv loj heev thiab mob rau daim siab.
Yog tias tus neeg mob raug yuam kom siv tshuaj ntau dua 10 hnub, tom qab ntawd hnub 11, kev kuaj ntshav yuav tsum tau ua los ntsuas nws txoj kev ua haujlwm. Tom qab 2 lub lis piam los ntawm kev pib siv cov tshuaj no, koj yuav tsum rov qab xav dua txog qhov yuav tsum tau kho ntxiv lossis txiav txim siab txog kev txiav cov tshuaj. Nws tseem yuav tsum nkag siab tias txhua tus kab mob muaj nws tus kheej txoj kev kho mob, piv txwv li, rau kev kho mob ntawm qhov tsis yooj yim mob ntawm pob ntseg nruab nrab, chav kawm ntawm kev kho mob tsis pub dhau 7 hnub rau cov neeg laus, thaum kho cov menyuam yaus hnub nyoog qis dua 2 xyoos tuaj yeem txuas ntxiv mus txog 10 hnub.
Yog tias tsim nyog lossis teeb meem los ntawm cov txheej txheem ntawm kev mob tshwm sim thiab kis tus kab mob, qee zaum cov neeg mob tau kho ua ntej augmentin nyob rau hauv txoj kev txhaj tshuaj, thiab tom qab ploj ntawm cov tsos mob hnyav thiab txhim kho hauv cov xwm txheej feem ntau, koj tuaj yeem hloov mus rau qhov ncauj tswj hwm ntawm cov tshuaj, uas yog, ntsiav tshuaj.
Koob tshuaj rau cov me nyuam
Raws li txoj cai, qhov muab xam ntawm txhua hnub ntawm Augmentin ntsiav tshuaj hauv kev xyaum kho mob yog nyob ntawm ntau yam: lub cev qhov hnyav ntawm tus menyuam, kev kis tus kab mob, qhov mob hnyav, hnub nyoog ntawm tus neeg mob, thiab muaj cov teeb meem tshwm sim. Rau cov menyuam qhov hnyav txog 40 kg, ntau npaum qhov tau muab xam raws li mg / 1 kg ntawm lub cev hnyav. Qhov ntau npaum li cas ntawm cov tshuaj ntawm lub tshuaj txiav txim siab los ntawm tus kws kho mob ua kom haum xeeb rau txhua tus neeg mob. Cov menyuam yaus lub cev hnyav dua 40 kg yuag yuag siv tshuaj kho "neeg loj".
Rau kev kho mob ntawm kev sib kis ntawm cov tawv nqaij thiab cov nqaij mos, kab mob pharyngitis thiab mob tonsillitis, tshuaj tsawg kawg ntawm augmentin tau txaus. Rau kev kho mob ntawm kev kis mob xws li sinusitis, mob pob ntseg ntawm pob ntseg hauv nruab nrab, cov txheej txheem ua mob ntawm sab sauv thiab sab hauv txoj hlab pa, cystitis, pyelonephritis thiab lwm yam kev mob ntawm cov kab mob genitourinary plab hnyuv siab, siab tshuaj ntawm cov tshuaj yuav tsum.
Cov tshuaj Augmentin nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj tsis yog siv hauv kev kho mob hauv kev kho mob rau cov neeg mob hnub nyoog qis dua 2 xyoos, txij li tsis muaj cov ntaub ntawv qhia tseeb txog kev nyab xeeb ntawm kev kho mob.
Augmentin ntau npaum rau cov neeg laus thiab cov menyuam hnub nyoog 14 xyoos rov hauv
Cov neeg laus thiab menyuam yaus hnub nyoog 14 xyoos lossis cov neeg mob uas hnyav dua 40 kg tau sau Augmentin ntawm tus nqi ntawm 1 ntsiav tshuaj peb zaug ib hnub rau kev kho mob me thiab mob nyhav. Txog kev kho cov txheej txheem sib txawv lossis nyuaj rau cov laus thiab cov menyuam yaus hnub nyoog 14 xyoos, raws li txoj cai, lwm daim ntawv tshuaj ntawm cov tshuaj tau muab tshuaj, ntau dua li kev txhaj tshuaj.
Rau cov neeg mob uas muaj hnub nyoog so haujlwm uas muaj qhov ua haujlwm tsis zoo ntawm lub raum thiab mob siab, cov tshuaj txhua hnub yuav hloov los ntawm tus kws kho mob uas koom nrog.
Sab sij huam
Nrog txoj kev siv kom yog ntawm Augmentin ntsiav tshuaj thiab muab xam cov tshuaj noj kom raug, cov tshuaj kom tag nrho yog ib txwm ua rau cov neeg mob tau tiv thaiv. Qee qhov xwm txheej, nrog rau tus tib neeg lub siab tsis sib thooj rau hauv tshuaj, cov kev mob tshwm sim txuas ntxiv tuaj yeem tsim:
- Los ntawm sab ntawm lub plab zom mov: xeev siab, mob hauv plab, tsam plab, mob plab, ntuav, raws plab, ua kom lub siab ua haujlwm tsis zoo, ua kom muaj kab mob siab,
- Los ntawm cov kab mob txeeb zis: mob raum tsis ua haujlwm, oliguria, lub raum tsis zoo,
- Los ntawm lub hauv nruab nrab thiab ntu mob hlwb: kiv taub hau, mob plab, mob taub hau, pw tsaug zog, los sis, hloov, tsaug zog heev, cov tsos mob ntawm lub cev, uas qhia nyob rau hauv kev ua kom tsis muaj zog, cov neeg mob tsis zoo rau qhov tshwm sim ib puag ncig.
Cov kev mob tshwm sim feem ntau suav nrog ua pob ua pob ua pob ua xua, ua pob ua xua, tawm pob (ua paug ntawm chaw mos rau cov poj niam thiab cov nqaij hauv qhov ncauj).
Nrog kev ua raws li cov kev cai ntau npaum li cas los ntawm tus kws kho mob thiab nrog txoj cai tswj hwm kev siv tshuaj, cov kev mob tshwm sim los ntawm kev noj cov Augmentin kev txhim kho tsuas yog hauv cov xwm txheej tsis tshua muaj.
Cov Yuav Tsum Muaj
Txawm hais tias dav ntawm lawv cov teebmeem, Augmentin ntsiav tshuaj muaj ib tug xov tooj ntawm contraindications. Cov no suav nrog:
- Ib leeg tsis kam rau penicillins, cephalosporins,
- Hypersensitivity rau ntu ntu ntawm cov tshuaj,
- Kev mob hnyav rau daim siab thiab lub raum,
- Cov menyuam yaus hnub nyoog qis dua 2 xyoos,
- Kev kis mob mononucleosis - thaum siv cov ntsiav tshuaj augmentin nrog kev kuaj mob no, kev tawm tsam ua xua tuaj yeem tshwm sim rau tus neeg mob daim tawv nqaij, uas yuav ua rau cov kev kuaj mob txaus los ntawm tus kab mob pathology.
Kev siv cov tshuaj thaum cev xeeb tub thiab pub niam mis
Augmentin raug sim hauv chav kuaj tsiaj. Raws li kev tshawb fawb ntau, ntsiav tshuaj ntawm cov tshuaj, txawm tias nyob rau hauv cov koob tshuaj siab, tsis muaj mutagenic thiab teratogenic cuam tshuam rau tus me nyuam hauv plab. Dua li ntawm qhov no, kev siv ib cov tshuaj raws li amoxicillin thiab clavulanic acid rau cov poj niam cev xeeb tub yog contraindicated, tshwj xeeb tshaj yog nyob rau thawj lub hlis ntawm cev xeeb tub. Hauv thawj 12 lub lis piam, kev tso ntawm tag nrho cov plab hnyuv siab raum thiab cov txheej txheem ntawm tus me nyuam hauv plab, thiab kev noj cov tshuaj thaum lub sijhawm no tuaj yeem ua rau tag nrho cov qog chromosomal tsis zoo thiab, vim li ntawd, kev txawv txav ntawm txoj kev txhim kho intrauterine. Tsis tas li ntawd, thaum cov kws tshawb fawb soj ntsuam cov tshuaj nyob rau hauv tus poj niam uas yug lub sijhawm tsis tau muaj menyuam thaum yug ntxov, nws tau pom tias txawm tias yog li ntawm kev txhaj tshuaj tiv thaiv kab mob augmentitis ua rau muaj kev pheej hmoo ua mob necrotic colitis hauv cov menyuam mos.
Raws li cov lus qhia rau cov tshuaj, Augmentin thaum lub sijhawm yoj tes yoj tes tsuas yog tsuas yog muaj feem ntau muaj mob thiab muab tias cov txiaj ntsig rau tus poj niam nyob deb dhau qhov kev pheej hmoo ntawm kev tsim kev phiv rau tus me nyuam hauv plab.
Kev siv cov Augmentitis thaum pub mis niam yog ua tau, tab sis tsuas yog ua raws li kev qhia nruj thiab nyob rau hauv kev saib xyuas ntawm tus kws kho mob. Nyob rau hauv tsis muaj qee qhov yuav tsum tau tus poj niam cev xeeb tub ntau dua qhov ntau npaum li tau qhia los ntawm tus kws kho mob, vim li amoxicillin nkag mus rau hauv niam mis thiab qhov ntau ntau tuaj yeem ua rau muaj kev cuam tshuam hauv tus menyuam lub siab, uas yog fraught nrog kev txhim kho kev mob tshwm sim hauv cov menyuam mos. Ntxiv nrog rau qhov kev pheej hmoo no, tsis muaj kev cuam tshuam txawv txav ntawm Augmentin rau lub cev ntawm tus menyuam tau txais niam mis tau raug kuaj pom hauv ntau cov kev tshawb fawb.
Cov lus qhia tshwj xeeb
Ua ntej pib siv cov tshuaj no, tus neeg mob yuav tsum qhia tus kws kho mob kom paub keeb kwm zoo txog nws txoj kev tiv taus cov tshuaj ntawm pawg penicillin thiab cephalosporins. Tsis tas li ntawd, nws yog qhov yuav tsum tau taw qhia seb puas muaj keeb kwm muaj kev fab tshuaj rau cov tshuaj thiab lawv cov khoom siv.
Hauv cov tshuaj, ntau qhov xwm txheej ntawm kev loj hlob ntawm kev tsis haum ntawm cov neeg mob rau cov tshuaj uas muaj penicillins tau piav qhia. Hauv qee kis, anaphylactic kev poob siab los ntawm kev tswj hwm tshuaj yeeb tuag taus! Txoj kev pheej hmoo ntawm kev txhim kho cov kev tsis haum rau penicillins lossis cephalosporins tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj mob muaj keeb lossis cov neeg muaj qhov tsis zoo nyob rau yav dhau los hauv kev teb rau kev siv amoxicillin lossis lwm yam tshuaj raws penicillin-based. Nrog rau qhov kev pheej hmoo siab ntawm kev phiv tshuaj, tus kws kho mob yuav tsum xaiv lwm txoj kev kho rau tus neeg mob uas tseem yuav ua kom zoo, tab sis kev nyab xeeb rau tus neeg mob lub cev.
Nrog kev txhim kho qhov mob anaphylactic los yog Quincke's edema hauv kev teb rau kev qhia lossis txais tos ntawm Augmentin, tus neeg mob yuav tsum txhaj tshuaj adrenaline sai, iv glucocorticosteroid cov tshuaj hormones. Nrog rau kev o hnyav thiab ua tsis taus pa ntawm tus neeg mob, yuav tsum tau ua pa pa sai sai rau qhov no, qhov mob plab txhaws yuav tsum tau ua.
Cov tshuaj Augmentin tau siv nrog kev ceev faj rau kev kho mob ntawm cov neeg laus thiab cov neeg mob uas muaj mob tsis zoo ntawm lub raum thiab lub siab ua haujlwm.
Txhawm rau kom txo cov kev phiv los ntawm kev zom zaub mov los ntawm kev siv tshuaj, augmentin ntsiav tshuaj raug pom zoo kom noj thaum pib noj mov.
Tom qab noj cov ntsiav tshuaj, cov neeg mob uas ua kom lub ntsej muag txhawm rau txha hniav laus tau hais qhia kom txhuam lawv cov hniav kom tsis txhob lwj lossis tawv ntawm tus txha hniav laus.
Cov neeg mob uas pib noj cov tshuaj amoxicillin yog qhov ua rau muaj sij hawm ntau dua prothrombin. Vim li ntawd nrog kev kho mob ua ke nrog augmentin thiab anticoagulants, cov neeg mob yuav tsum tau kuaj ntshav ib zaug mus soj ntsuam qhov tshuaj tiv thaiv.
Cov neeg mob uas txo qis cov diuresis (tso zis) tsis tshua pom muaj muaju hauv cov zis. Raws li txoj cai, cov tsos mob no tshwm sim nrog kev tswj hwm hauv tsoomfwv ntawm cov tshuaj.Lub sijhawm kho mob nrog tshuaj amoxicillin, nws raug nquahu kom tus neeg mob haus lub ntim dej txaus kom tiv thaiv kev tsim cov tshuaj muaju hauv cov zis.
Kev kho ntev ntev nrog Augmentin tuaj yeem ua rau kom muaj kev loj hlob sai ntawm cov kab mob me ua kom tsis haum rau cov tshuaj ntawm cov tshuaj. Nyob rau lub sijhawm ntev ntawm kev siv tshuaj, nws raug nquahu kom soj ntsuam haujlwm ntawm lub raum, daim siab thiab cov ntshav los ntawm kev tso zis thiab ntshav.
Thaum lub sijhawm kho nrog Augmentin, nws yog txwv tsis pub haus dej haus cawv, txij li kev sib cuam tshuam ntawm kev haus dej cawv thiab cov tshuaj ua haujlwm hauv cov tshuaj tuaj yeem ua rau muaj tshuaj lom rau daim siab thiab lub siab hauv lub siab.
Augmentin ntsiav tshuaj tsis muaj qhov tsis zoo ntawm qhov kev hloov pauv thiab tsis cuam tshuam rau kev tswj hwm lub tsheb thiab lwm yam txheej txheem.
Kev sib cuam tshuam ntawm cov tshuaj nrog lwm cov tshuaj
Cov tshuaj Augmentin tsis pom zoo kom noj ib txhij nrog Allopurinol vim tias qhov kev pheej hmoo siab ntawm kev phiv tshuaj thiab phiv rau hauv tus neeg mob. Yog tias koj twb noj Allopurinol, koj yuav tsum qhia koj tus kws kho mob.
Thaum lub sijhawm siv Augmentin, ntxiv rau lwm cov tshuaj tua kab mob ntawm pab pawg neeg penicillin, cov tshuaj tiv thaiv tsis pub muaj menyuam yuav poob qis, uas yuav tsum paub rau cov poj niam uas nyiam hom kev tiv thaiv tiv thaiv tsis pub muaj menyuam hauv plab.
Pharmacological pawg
| Hmoov rau kev tshem tawm ntawm qhov ncauj | 5 ml |
| yam tshuaj: | |
| amoxicillin trihydrate (hauv amoxicillin) | 125 mg |
| 200 mg | |
| 400 mg | |
| poov tshuaj clavulanate (hauv cov ntsiab lus ntawm clavulanic acid) 1 | 31,25 mg |
| 28,5 mg | |
| 57 mg | |
| tus zam: xanthan ntawm cov pos hniav - 12.5 / 12.5 / 12.5 mg, aspartame - 12.5 / 12.5 / 12.5 mg, succinic acid - 0.84 / 0.84 / 0.84 mg, colloidal silicon dioxide - 25/25/25 mg, hypromellose - 150 / 79.65 / 79.65 mg, txiv kab ntxwv tsw 1 - 15/15/15 mg, txiv kab ntxwv tsw 2 - 11.25 / 11.25 / 11.25 mg, tsw raspberry - 22.5 / 22.5 / 22.5 mg, cov tshuaj tsw qab "Lub suab tawm suab" - 23.75 / 23.75 / 23.75 mg, silicon dioxide - 125 / txog 552 / txog li 900 mg |
1 Hauv kev tsim cov tshuaj, poov tshuaj clavulanate raug nteg nrog 5% ntau dhau.
| Zaj duab xis-coated ntsiav tshuaj | 1 tab. |
| yam tshuaj: | |
| amoxicillin trihydrate (hauv amoxicillin) | 250 mg |
| 500 mg | |
| 875 mg | |
| poov tshuaj clavulanate (hais txog clavulanic acid) | 125 mg |
| 125 mg | |
| 125 mg | |
| tus zam: magnesium stearate - 6.5 / 7.27 / 14.5 mg, sodium carboxymethyl hmoov txhuv nplej siab - 13/21/29 mg, colloidal silicon dioxide - 6.5 / 10.5 / 10 mg, MCC - 650 / txog 1050/396, 5 mg | |
| zaj duab xis sheath: titanium dioxide - 9.63 / 11.6 / 13.76 mg, hypromellose (5 cps) - 7.39 / 8.91 / 10.56 mg, hypromellose (15 cps) - 2.46 / 2.97 / 3.52 mg, macrogol 4000 - 1.46 / 1.76 / 2.08 mg, macrogol 6000 - 1.46 / 1.76 / 2.08 mg, dimethicone 500 ( kua roj silicone) - 0.013 / 0.013 / 0.013 mg, dej huv 1 - - / - / - |
1 Cov dej lim tawm hauv cov txheej txheej zaj duab xis.
Kev piav qhia ntawm daim ntawv tshuaj
Hmoov: dawb lossis yuav luag dawb, nrog tus yam ntxwv tsw. Thaum diluted, ib qho kev ncua ntawm dawb lossis yuav luag dawb yog tsim. Thaum sawv ntsug, ib qho dej dawb lossis dawb yuav luag nag lossis daus maj mam ua kom qeeb.
Ntsiav tshuaj, 250 mg + 125 mg: them nrog zaj duab xis membrane los ntawm dawb mus rau yuav luag dawb, kheej li lub qw hauv cov duab, nrog cov ntawv sau "AUGMENTIN" ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.
Ntsiav tshuaj, 500 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb hauv cov xim, oval, nrog cov ntawv sau extruded "AC" thiab txoj kev pheej hmoo ntawm ib sab.
Ntsiav tshuaj, 875 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb, kheej li lub qw, nrog cov tsiaj ntawv "A" thiab "C" ntawm ob sab thiab ib txoj kab txhaum ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.
Cov Tshuaj Hauv Tshuaj
Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.
Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid beta-lactamases, uas feem ntau lub luag haujlwm tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv cov chromosomal beta-lactamases ntawm hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.
Muaj cov clavulanic acid nyob hauv Augmentin ® kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.
Hauv qab no yog cov haujlwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid hauv vitro .
Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid
Gram-zoo aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia astero> suav nrog Tus kab mob Streptococcus pyogenes 1.2, Streptococcus agalactiae 1.2 (lwm beta hemolytic streptococci) 1,2, Dab Tsi Staphylococcus aureus (rhiab rau methicillin) 1, Staphylococcus saprophyticus (rhiab rau methicillin), coagulase-negative staphylococci (rhiab rau methicillin).
Gram-zoo anaerobes: Clostr> suav nrog Peptostreptococcus magnus, Peptostreptococcus micros.
Gram-negative aerobes: Tus mob Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.
Gram-negative anaerobes: Bactero> suav nrog Bactero> suav nrog Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.
Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim
Gram-negative aerobes: Escherichia coli 1, Klebsiella spp., suav nrog Klebsiella oxytoca, Klebsiella pneumoniae 1, Proteus spp., suav nrog Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.
Gram-zoo aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus mob ntsws 1,2 pab pawg neeg streptococcus Viridans.
Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid
Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.
Lwm yam: Chlamydia spp., suav nrog Chlamydia mob ntsws, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.
1 Rau cov kab mob no, kev kho mob ua tau zoo ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid tau ua kom pom hauv kev tshawb fawb soj ntsuam.
2 Hom kab ntawm cov kab mob no tsis tsim cov tshuaj beta-lactamase. Kev nkag siab nrog amoxicillin monotherapy qhia zoo ib yam li kev nkag siab zoo rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.
Cov Tshuaj Pharmacokinetics
Ob qho khoom xyaw tseem ceeb ntawm Augmentin ® kev npaj - amoxicillin thiab clavulanic acid - tau sai thiab tag nrho los ntawm kev mob plab zom mov tom qab kev tswj hwm ntawm qhov ncauj. Qhov nqus ntawm cov khoom xyaw nquag ntawm cov tshuaj Augmentin ® yog qhov zoo dua rau thaum muaj kev noj tshuaj thaum pib noj mov.
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob siv 40 mg + 10 mg / kg / hnub ntawm Augmentin ® hauv peb koob tshuaj, hmoov rau lub qhov ncauj ncua, 125 mg + 31.25 mg hauv 5 ml (156.25 mg).
Yooj yim pharmacokinetic
| Tshuaj | Koob tshuaj mg / kg | Cmax mg / l | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| 40 | 7,3±1,7 | 2,1 (1,2–3) | 18,6±2,6 | 1±0,33 | |
| 10 | 2,7±1,6 | 1,6 (1–2) | 5,5±3,1 | 1,6 (1–2) |
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2–12 xyoo rau ntawm lub plab khoob tau Augmentin ®, hmoov rau lub qhov ncauj ncua, 200 mg + 28.5 mg hauv 5 ml (228 , 5 mg) ntawm ib koob ntawm 45 mg + 6.4 mg / kg / hnub, muab faib ua ob zaug.
Yooj yim pharmacokinetic
| Yam khoom muaj sia | Cmax mg / l | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| Amoxicillin | 11,99±3,28 | 1 (1–2) | 35,2±5 | 1,22±0,28 |
| Clavulanic acid | 5,49±2,71 | 1 (1–2) | 13,26±5,88 | 0,99±0,14 |
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau txais hauv kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg tuaj yeem noj qab haus huv tau noj ib zaug ntawm Augmentin ®, hmoov rau lub qhov ncauj ncua, 400 mg + 57 mg hauv 5 ml (457 mg).
Yooj yim pharmacokinetic
| Yam khoom muaj sia | Cmax mg / l | Tmax xyob h | AUC, mg · h / l |
| Amoxicillin | 6,94±1,24 | 1,13 (0,75–1,75) | 17,29±2,28 |
| Clavulanic acid | 1,1±0,42 | 1 (0,5–1,25) | 2,34±0,94 |
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb sib txawv, thaum cov neeg tuaj yeem yoo mov sai:
- 1 tab. Augmentin ®, 250 mg + 125 mg (375 mg),
- 2 ntsiav tshuaj Augmentin ®, 250 mg + 125 mg (375 mg),
- 1 tab. Augmentin ®, 500 mg + 125 mg (625 mg),
- 500 mg ntawm amoxicillin,
- 125 mg ntawm clavulanic acid.
Yooj yim pharmacokinetic
| Tshuaj | Koob tshuaj mg | Cmax mg / ml | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| Augmentin ®, 250 mg + 125 mg | 250 | 3,7 | 1,1 | 10,9 | 1 |
| Augmentin ®, 250 mg + 125 mg, 2 ntsiav tshuaj | 500 | 5,8 | 1,5 | 20,9 | 1,3 |
| Augmentin ®, 500 mg + 125 mg | 500 | 6,5 | 1,5 | 23,2 | 1,3 |
| Amoxicillin 500 mg | 500 | 6,5 | 1,3 | 19,5 | 1,1 |
| Augmentin ®, 250 mg + 125 mg | 125 | 2,2 | 1,2 | 6,2 | 1,2 |
| Augmentin ®, 250 mg + 125 mg, 2 ntsiav tshuaj | 250 | 4,1 | 1,3 | 11,8 | 1 |
| Clavulanic acid, 125 mg | 125 | 3,4 | 0,9 | 7,8 | 0,7 |
| Augmentin ®, 500 mg + 125 mg | 125 | 2,8 | 1,3 | 7,3 | 0,8 |
Thaum siv cov tshuaj Augmentin ®, ntshav ntau ntawm amoxicillin zoo ib yam li cov tshuaj noj ntawm qhov ncauj ntawm amoxicillin koob tshuaj sib npaug.
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb cais, thaum cov neeg tuaj yeem noj qab haus huv txaus noj:
- 2 ntsiav tshuaj Augmentin ®, 875 mg + 125 mg (1000 mg).
Yooj yim pharmacokinetic
| Tshuaj | Koob tshuaj mg | Cmax mg / l | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| 1750 | 11,64±2,78 | 1,5 (1–2,5) | 53,52±12,31 | 1,19±0,21 | |
| 250 | 2,18±0,99 | 1,25 (1–2) | 10,16±3,04 | 0,96±0,12 |
Raws li nrog cov lus qhia iv ntawm kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid muaj nyob hauv ntau cov ntaub so ntswg thiab cov kua dej interstitial (gall zais zis, lub plab hauv plab, tawv nqaij, rog thiab cov leeg nqaij, synovial thiab peritoneal kua, bile, purulent paug). )
Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tau tias kwv yees li 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin hauv ntshav plasma khi rau cov ntshav plasma protein.
Hauv kev tshawb nrhiav tsiaj, tsis muaj kev txuam ntawm lub Cheebtsam ntawm Augmentin ® kev npaj hauv ib qho khoom hauv lub cev.
Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Cov kab ntawm clavulanic acid kuj tseem yuav pom nyob hauv niam cov kua mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab thiab ua paug rau ntawm lub qhov ncauj mob ntawm lub qhov ncauj, tsis muaj lwm yam tsis zoo ntawm amoxicillin thiab clavulanic acid rau kev noj qab haus huv ntawm cov niam mis-pub mis paub.
Cov kev tshawb fawb tsiaj yug me nyuam tau pom tias amoxicillin thiab clavulanic acid hla qhov chaw teeb meem. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.
10-25% ntawm thawj zaug koob tshuaj amoxicillin raug ntiab tawm los ntawm ob lub raum ua lub zog tsis haum rau lub cev (cov tshuaj penicilloic acid). Clavulanic acid tau dav dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid thiab amino-4-hydroxy-butan-2-ib thiab tau tawm ntawm cov raum GIT, nrog rau cov huab cua uas tas sijhawm hauv daim ntawv carbon dioxide.
Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab.
Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid raug tso tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab noj 1 lub rooj. 250 mg + 125 mg lossis 1 ntsiav tshuaj 500 mg + 125 mg.
Kev tswj hwm tib lub sij hawm ntawm probenecid qeeb ua rau qhov kev zam ntawm amoxicillin, tab sis tsis yog clavulanic acid (saib "Kev Sib Hloov").
Kev Taw Qhia Augmentin ®
Kev sib xyaw ntawm amoxicillin nrog clavulanic acid yog qhia rau kev kho mob ntawm cov kab mob ntawm cov chaw hauv qab no tshwm sim los ntawm cov kab mob me me nkag siab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid:
cov mob ua pa sab sauv (suav nrog rau tus mob ENT), xws li ua mob tonsillitis, mob ntsws, mob otitis, feem ntau tshwm sim Tus kab mob Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 thiab Streptococcus pyogenes, (tshwj tsis yog Augmentin ntsiav tshuaj 250 mg / 125 mg),
cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, mob ntsws mob ntsws, thiab mob ntsws, feem ntau tshwm sim Kab mob ntsws Streptococcus mob ntsws, Haemophilus khaub thuas 1 thiab Moraxella catarrhalis 1,
mob txeeb zig, xws li mob cystitis, tus mob urethritis, pyelonephritis, kis mob rau poj niam lub cev ua paug, feem ntau tshwm sim los ntawm hom tsiaj hauv tsev neeg Enterobacteriaceae 1 (feem ntau yog Escherichia coli 1 ), Staphylococcus saprophyticus thiab hom Enterococcusli zoo li kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae 1,
daim tawv nqaij thiab cov nqaij mos muag kis mob feem ntau tshwm sim Staphylococcus aureus 1, Tus kab mob Streptococcus pyogenes thiab hom Bacteroides 1,
kis mob ntawm cov pob txha thiab pob qij txha, xws li osteomyelitis, feem ntau tshwm sim Staphylococcus aureus 1, yog tias tsim nyog, kho lub sijhawm ntev ntev yog qhov ua tau.
cov kab mob odontogenic, piv txwv li kab mob txha caj qaum, odontogenic maxillary sinusitis, mob hniav ntau heev nrog nthuav tawm cellulitis (tsuas yog rau cov ntsiav tshuaj Augmentin cov ntawv, ntau npaum li 500 mg / 125 mg, 875 mg / 125 mg),
lwm cov kab mob sib xyaw (piv txwv, septic rho menyuam, tom qab sepsis, mob intraabdominal sepsis) yog ib feem ntawm kev kho mob kauj ruam (tsuas yog rau cov ntsiav tshuaj Augmentin ntau npaum 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),
1 Cov neeg sawv cev ntawm cov kab mob tsis txawv txav tsim cov beta-lactamase, uas ua rau lawv tsis raug tshuaj amoxicillin (saib. Pharmacodynamics).
Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag. Augmentin ® tseem qhia tau rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me uas tsim cov beta-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.
Qhov rhiab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av thiab dhau sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.
Cev xeeb tub thiab lactation
Hauv kev tshawb fawb ntawm kev ua tiav tsiaj hauv tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin ® tsis ua rau muaj teebmeem teratogenic.
Hauv txoj kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev puas ua ntej, nws tau pom tias kev kho nrog prophylactic nrog Augmentin be tej zaum cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos. Zoo li txhua yam tshuaj, Augmentin ® tshuaj tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias cov kev cia siab pab rau leej niam ntau dua qhov muaj feem yuav ua rau muaj menyuam hauv plab.
Cov tshuaj Augmentin ® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab lossis ua paug rau ntawm cov kua qog ua rau lub qhov ncauj ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov tshuaj yeeb dej caw ntawm cov tshuaj no mus rau niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos niam mis.Yog tias muaj qhov tshwm sim tsis zoo hauv cov menyuam mos uas tseem noj niam mis, nws yuav tsum tau tsum tsis txhob pub niam mis.
Sab sij huam
Cov xwm txheej tsis zoo uas tau nthuav tawm hauv qab no yog teev raws li kev puas tsuaj rau cov kabmob thiab cov nruab nrog cev thiab qhov ntau zaus tshwm sim. Qhov ntau zaus ntawm kev tshwm sim tau txiav txim siab raws li hauv qab no: ntau heev - /1 / 10, feem ntau ≥1 / 100 thiab PV, ntshav liab, eosinophilia, thrombocytosis.
Los ntawm lub nruab zog: tsis tshua muaj tshwm sim - angioedema, kev phiv tshuaj anaphylactic, tus mob zoo ib yam li kev mob ntshav dej, tshuaj tsis haum vasculitis.
Los ntawm lub paj hlwb: tso tsis tau - kiv taub hau, mob taub hau, tsis tshua muaj tshwm sim - thim rov qab hyperactivity, convulsions (txiav tau tuaj yeem tshwm sim rau cov neeg mob uas lub raum tsis ua haujlwm, zoo li hauv cov neeg uas tau txais cov tshuaj ntau heev), insomnia, ntxhov siab, ntxhov siab, hloov tus cwj pwm.
- cov neeg laus: ntau heev - raws plab, nquag - xeev siab, ntuav,
- menyuam yaus: feem ntau - raws plab, xeev siab, ntuav,
- tag nrho cov pejxeem: xeev siab yog feem ntau cuam tshuam nrog kev siv cov tshuaj ntau ntawm cov tshuaj. Yog tias tom qab pib noj cov tshuaj muaj qhov tsis txaus siab los ntawm lub plab hnyuv, tuaj yeem tshem tawm yog tias Augmentin ® noj thaum pib noj mov, tsis tshua zoo rau kev zom, tsis tshua muaj kab mob tua kab mob (nrog rau pseudomembranous colitis thiab hemorrhagic colitis), cov plaub hau dub »Tus nplaig, mob plab, mob plab, tshem tawm ntawm txheej txheej hniav txheej hniav txha hniav laus hauv menyuam yaus. Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob ua kom pom cov hniav, txij li txhuam koj cov hniav tau txaus.
Nyob rau ib feem ntawm daim siab thiab kais plab: tsis cuag li - ib qho kev nce ntawm ib qho txiaj ntsig ntawm AST thiab / lossis ALT. Qhov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob beta-lactam, tab sis nws qhov tseem ceeb hauv cov chaw kho mob tsis paub. Tsis tshua muaj - kab mob siab thiab mob cholestatic daj ntseg. Cov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob nrog penicillin tshuaj tua kab mob thiab cephalosporins. Kev nce siab ntawm bilirubin thiab alkaline phosphatase.
Cov kev mob tshwm sim los ntawm daim siab yog pom feem ntau hauv cov txiv neej thiab cov neeg laus laus thiab yuav cuam tshuam nrog kev kho mob mus ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus.
Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, tab sis qee qhov xwm txheej lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg mob uas mob nyhav los yog cov neeg mob tau txais cov tshuaj hepatotoxic.
Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: tsis ncaw - pob khaus, khaus, urticaria, tsis tshua muaj erythema multiforme, tsis tshua muaj Stevens-Johnson syndrome, mob ua paug rau daim tawv nqaij, ua rau mob ua paug, ua rau mob ua paug, ua paug rau tus mob txha nqaj qaum.
Yog tias muaj tawv nqaij tsis haum, kho nrog Augmentin ® yuav tsum tsis ua mus ntxiv.
Los ntawm ob lub raum thiab mob txeeb zig: muaj tsawg kawg - interstitial nephritis, crystalluria (saib "Overdose"), hematuria.
Kev sib txuam
Kev siv ua ke ib txhij ntawm cov tshuaj Augmentin ® thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin ® thiab probenecide tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid.
Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol.
Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li kev siv Augmentin thiab methotrexate ntau tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate.
Zoo li lwm yam tshuaj tua kab mob, Augmentin ® kev npaj yuav cuam tshuam rau lub plab hnyuv microflora, ua rau kev txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua haujlwm ntawm kev sib xyaw ua ke ntawm qhov ncauj.
Cov ntawv nyeem piav qhia feem ntau tsis tshua muaj neeg nce MHO hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias tsim nyog, txoj kev tswj hwm ntawm Augmentin ® npaj nrog PV anticoagulants lossis MHO yuav tsum tau ua tib zoo saib xyuas thaum sau tshuaj lossis thim kev Augmentin ® kev npaj kho kom haum rau cov tshuaj anticoagulants rau kev tswj hwm qhov ncauj.
Tsuas tshuaj thiab tswj hwm
Kev noj tshuaj rau lub cev yog tsim tshwj xeeb, nyob ntawm seb muaj hnub nyoog, hnyav lub cev, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav npaum li cas.
Txhawm rau kom txo qis lub plab zom mov tsis zoo thiab ua kom zoo dua ntawm kev nqus, cov tshuaj yuav tsum tau noj thaum pib noj mov. Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.
Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.
Yog tias tsim nyog, nws yog qhov ua tau los ua cov kev kho mob stepwise (thawj kev tswj hwm kev siv tshuaj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).
Nws yuav tsum nco ntsoov tias 2 tab. Augmentin ®, 250 mg + 125 mg tsis sib npaug rau 1 ntsiav tshuaj. Augmentin ®, 500 mg + 125 mg.
Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos thiab laus dua lossis hnyav 40 kg lossis ntau dua. Nws raug nquahu kom siv 11 ml ntawm kev ncua ib ntus ntawm kev siv tshuaj ntawm 400 mg + 57 mg hauv 5 ml, uas yog sib npaug rau 1 lub rooj. Augmentin ®, 875 mg + 125 mg.
1 tab. 250 mg + 125 mg 3 zaug hauv ib hnub rau kev kis mob me me mus rau mob hnyav. Hauv kev kis mob hnyav (suav nrog mob ntsws thiab mob txeeb zig, mob ntsws thiab mob txawv txav ntawm txoj hlab ntsws), lwm txoj kev noj tshuaj ntawm Augmentin recommended raug pom zoo.
1 tab. 500 mg + 125 mg 3 zaug ib hnub.
1 tab. 875 mg + 125 mg 2 zaug ib hnub.
Cov menyuam hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua li 40 kg. Kev xam qhov tseeb yog nqa tawm raws li lub hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg / hnub lossis hauv ml ntawm kev ncua. Qhov koob tshuaj txhua hnub tau muab faib ua 3 koob tshuaj txhua 8 teev (125 mg + 31.25 mg) lossis 2 koob tshuaj txhua 12 teev (200 mg + 28.5 mg, 400 mg + 57 mg). Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.
Augmentin ® ntau npaum cov tshuaj (suav muab xam raws li amoxicillin)
| Koob tshuaj | Ncua Sijhawm 4: 1 (125 mg + 31.25 mg hauv 5 ml), hauv 3 koob txhua 8 teev | Ncua Sijhawm 7: 1 (200 mg + 28.5 mg hauv 5 ml lossis 400 mg + 57 mg hauv 5 ml), hauv 2 koob tshuaj txhua 12 teev |
| Tsawg | 20 mg / kg / hnub | 25 mg / kg / hnub |
| Siab | 40 mg / kg / hnub | 45 mg / kg / hnub |
Kev txhaj tshuaj qis ntawm Augmentin ® raug pom zoo rau kev kho mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau cov mob tonsillitis.
Kev txhaj tshuaj ntau ntawm Augmentin High raug pom zoo rau kev kho mob ntawm cov kab mob xws li otitis media, sinusitis, kis mob qis qis ntawm txoj hlab ntsws thiab mob txeeb zig, mob pob txha thiab pob qij txha.
Muaj cov ntaub ntawv kuaj mob tsis txaus kom pom zoo siv Augmentin ® hauv ib koob ntau dua 40 mg + 10 mg / kg hauv 3 koob tshuaj (4: 1 ncua kev kawm) rau cov menyuam yaus hnub nyoog qis dua 2 xyoos.
Cov menyuam txij thaum yug mus txog 3 hlis. Vim lub cev tsis muaj nuj nqi ntawm qhov muaj peev xwm zam ntawm ob lub raum, qhov pom zoo koob ntawm Augmentin ® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.
Cov menyuam yug ntxov ntxov. Tsis muaj cov lus qhia hais txog qhov muab tshuaj.
Cov pab pawg neeg tshwj xeeb
Cov neeg laus cov neeg mob. Kev kho ntawm cov tshuaj ntau npaum li cas tsis tas yuav tsum tau ua; Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, cov koob tshuaj uas tsim nyog rau cov neeg laus uas lub raum tsis ua haujlwm.
Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los hloov lub tswv yim hloov cov koob tshuaj hauv cov neeg mob zoo li no.
Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Kev kho ntawm cov tshuaj ntau npaum li cas yog raws li qhov pom zoo tshaj plaws ntawm koob tshuaj amoxicillin thiab tus nqi creatinine tshem tawm.
Augmentin age ntau npaum kev noj tshuaj
| Cl creatinine, ml / min | 4: 1 ncua kev kawm (125 mg + 31.25 mg hauv 5 ml) | Ncua Sijhawm 7: 1 (200 mg + 28.5 mg hauv 5 ml lossis 400 mg + 57 mg hauv 5 ml) | Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg | Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg | Cov ntsiav tshuaj ua yeeb yaj kiab, 875 mg + 125 mg |
| >30 | Tsis tas yuav tsum kho npaum li cas | Tsis tas yuav tsum kho npaum li cas | Tsis tas yuav tsum kho npaum li cas | Tsis tas yuav tsum kho npaum li cas | Tsis tas yuav tsum kho npaum li cas |
| 10–30 | 15 mg + 3.75 mg / kg 2 zaug hauv ib hnub, qhov ntau kawg yog 500 mg + 125 mg 2 zaug ib hnub | — | 1 tab. (nrog mob sib khuav mus txog rau theem nrab) 2 zaug ib hnub | 1 tab. (nrog mob sib khuav mus txog rau theem nrab) 2 zaug ib hnub | — |
| ® hauv cov ntshav, ib koob thib ob ntxiv ntawm 15 mg + 3.75 mg / kg yuav tsum tau txhaj tom qab kev kho mob hemodialysis. |
Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg: Cov koob tshuaj hloov kho raws li qhov xav tau ntau tshaj plaws ntawm amoxicillin.
2 tab. 250 mg + 125 mg hauv 1 koob tshuaj txhua 24 teev
Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (1 ntsiav tshuaj) thiab lwm 1 lub tshuaj. tom kawg ntawm kev lim ntshav lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).
Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg: Cov koob tshuaj hloov kho raws li qhov xav tau ntau tshaj plaws ntawm amoxicillin.
1 tab. 500 mg + 125 mg hauv 1 koob tshuaj txhua 24 teev
Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (1 ntsiav tshuaj) thiab lwm 1 lub tshuaj. tom kawg ntawm kev lim ntshav lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).
Tus txheej txheem ntawm kev npaj ntawm qhov raug ncua
Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug. Kwv yees li 60 ml ntawm cov dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, cia lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv kev hais txog, hais txog 92 ml dej yuav tsum tau npaj qhov kev ncua rau kev pab ntau tshaj 125 mg + 31.25 mg thiab 64 ml dej rau kom ntau li ntawm 200 mg + 28.5 mg thiab 400 mg + 57 mg
Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.
Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov ncua kev ncua ntawm Augmentin ® kev npaj yuav tuaj yeem tov nrog dej nyob hauv qhov sib piv ntawm 1: 1.
Noj ntau dhau
Cov tsos mob tuaj yeem pom los ntawm lub plab zom mov thiab cuam tshuam hauv dej-electrolyte tshuav nyiaj li cas.
Amoxicillin crystalluria tau piav qhia, qee qhov xwm txheej ua rau txoj kev txhim kho lub raum tsis ua haujlwm (saib "Cov Lus Qhia Tshwj Xeeb").
Cov qaug dab peg hauv cov neeg mob uas lub raum tsis zoo, thiab rau cov neeg uas tau txais cov tshuaj ntau heev.
Kev Kho Mob: Cov tsos mob los ntawm kev mob plab hnyuv - kev kho mob, kev them nyiaj tshwj xeeb rau qhov ib txwm ua ntawm dej-electrolyte sib npaug. Amoxicillin thiab clavulanic acid tuaj yeem tshem tawm cov ntshav tawm los ntawm hemodialysis.
Cov txiaj ntsig ntawm kev soj ntsuam ib txwm muaj nrog 51 tus menyuam nyob hauv lub chaw tso tshuaj lom tau qhia tias kev tswj hwm ntawm amoxicillin ntawm koob tshuaj tsawg dua 250 mg / kg tsis tau ua rau cov tsos mob tseem ceeb thiab tsis tas yuav ua kom mob plab.
Daim ntawv tso tawm
Hmoov rau kev tshem tawm ntawm qhov ncauj, 125 mg + 31.25 mg hauv 5 ml. Hauv lub raj mis ntawm cov ntshiab iav, kaw los ntawm lub hau ntswj-ntawm aluminium cap nrog kev tswj ntawm thawj qhib, 11,5 g .1 fl. ua ke nrog nrog ntsuas lub hau hauv kab ntawv tuab.
Hmoov rau qhov kev npaj tawm ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj, 200 mg + 28.5 mg hauv 5 ml, 400 mg + 57 mg hauv 5 ml. Hauv lub khob iav pob tshab kaw nrog lub hau ntswj-ntawm txhuas lub taub hau nrog kev qhib thawj qhov tswj, 7.7 g (rau qhov ntau npaum li 200 mg + 28.5 mg hauv 5 ml) lossis 12.6 g (rau kev noj ntau npaum li 400 mg + 57 mg hauv 5 ml ) 1 fl. ua ke nrog ntsuas lub ntsuas los yog lub koob txhaj tshuaj hauv lub thawv ntawv thawv.
Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg. Hauv aluminium / PVC blister 10 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntawv ci ntawv nyiaj ntim khoom hauv thawv ntawv thawv.
Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg. Hauv aluminium / PVC / PVDC blister 7 lossis 10 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntim ntawm cov ntawv ci laminated txhuas hauv thawv ntawv thawv.
Cov ntsiav tshuaj ua yeeb yaj kiab, 850 mg + 125 mg. Hauv aluminium / PVC blister 7 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntawv ci ntawv nyiaj ntim khoom hauv thawv ntawv thawv.
Chaw tsim tshuaj paus
SmithKlein Puam P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.
Lub npe thiab chaw nyob ntawm tus neeg tuav txoj cai lij choj uas lawv sau npe rau daim ntawv pov thawj: GlaxoSmithKline Trading CJSC. 119180, Moscow, Yakimanskaya nab., 2.
Xav paub ntau ntxiv, sib cuag: GlaxoSmithKline Trading CJSC. 121614, Moscow, st. Krylatskaya, 17, bldg. 3, pem teb 5. Kev Lag Luam Chaw Ua Si "Roob Krylatsky."
Xovtooj: (495) 777-89-00, fev: (495) 777-89-04.
Augmentin ® hnub tas sijhawm
zaj duab xis-ntsiav tshuaj 250 mg + 125 mg 250 mg + 125 - 2 xyoos.
zaj duab xis-coated ntsiav tshuaj 500 mg + 125 mg - 3 xyoos.
zaj duab xis-ntsiav tshuaj 875 mg + 125 mg - 3 xyoos.
hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj 125mg + 31.25mg / 5ml - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.
hmoov rau kev ncua rau kev tswj hwm qhov ncauj 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.
hmoov rau kev ncua rau kev tswj hwm qhov ncauj 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.
Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.
Kev Sib Sau thiab daim ntawv ntawm kev tso tawm
Peb sau cov foos tso tawm tshuaj tawm hauv tebchaws Russia:
- Cov kev xaiv nyob rau hauv daim ntawv ntawm cov hmoov qhuav rau kev npaj ntawm qhov ncauj ncua, uas muaj 125 mg + 31.25 mg hauv 5 ml ntawm cov tshuaj tiav,
- Augmentin nyob rau hauv daim ntawv ntawm hmoov qhuav rau kev npaj ntawm qhov ncauj raug tshem tawm uas muaj 200 mg + 28.5 mg hauv 5 ml ntawm cov tshuaj tiav,
- Augmentin hmoov muaj 400 mg + 57 mg hauv 5 ml ntawm qhov kev ua tiav,
- Augmentin hmoov, npaj rau kev npaj ntawm kev daws rau kev tswj hwm kev tso dej,
- Augmentin ES hmoov rau kev npaj rau ib qho kev ncua ntawm cov menyuam yaus, uas muaj 600 mg + 42.9 mg hauv 5 ml,
- 500mg + 125mg ntsiav tshuaj
- 875 mg + 125 mg ntsiav tshuaj
- Augmentin ntsiav tshuaj 250mg + 125 mg.
Cov chaw kho mob thiab chaw muag tshuaj: ib qho tshuaj tua kab mob ntawm sab-spectrum penicillin pawg nrog beta-lactamase inhibitor.
Augmentin siv rau dab tsi?
Raws li cov lus qhia Augmentin yog siv rau cov kab mob kis tau los ntawm cov kab mob me me rau cov tshuaj. Cov no suav nrog:
- Kev kis tus kab mob ENT kabmob - otitis media, tonsillitis, pharyngitis, sinusitis,
- Cov kab mob ntawm txoj hlab ntsws bronchopulmonary: mob ntsws zoo, ua kom mob ntsws txhaws ntev, mob ntsws,
- Qhov tsis yog tshwj xeeb kev kis mob ntawm cov kab mob genitourinary: cystitis, pyelonephritis, urethritis, rau cov poj niam - cov kab mob vulvovaginitis, endocervicitis,
- Cov tawv nqaij thiab cov nqaij mos sib kis kab mob,
- Mob voos hauv plab - mob plab zawv plab, salmonellosis,
- Musculoskeletal mob - osteomyelitis, qee yam mob kis mob,
- Kev kis hniav - kab mob, hniav qog,
- Gonorrhea
- Sepsis.
Tsis tas li, kev siv Augmentin yog qhia rau kev sib kis kis mob tom qab lub sijhawm txiav txim siab tom qab.
Pharmacological kev txiav txim
Broad-spectrum tshuaj tua kab mob. Nws muaj cov kab mob bacteriolytic (cuam tshuam rau cov kab mob).Nws nquag tawm tsam ntau ntawm aerobic (kev tsim tawm tsuas yog nyob hauv qhov muaj oxygen) thiab anaerobic (muaj peev xwm muaj qhov tsis muaj oxygen) muaj cov kab mob zoo-aerobic thiab cov tsiaj ntawv muaj sia, suav nrog cov kab mob uas ua cov beta-lactamase (ib qho enzyme uas txav penicillins).
Clavulanic acid, uas yog ib feem ntawm kev npaj, muab cov tsis kam ntawm amoxicillin rau kev cuam tshuam ntawm beta-lactamases, nthuav cov spectrum ntawm nws qhov kev nqis tes ua.
Cov lus qhia rau kev siv
Raws li cov lus qhia rau kev siv Augmentin, kev noj tshuaj ntau dua tau tsim kho raws tus neeg lub hnub nyoog, lub cev nyhav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav ntawm tus mob. Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).
- Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua. 1 ntsiav tshuaj 250 mg / 125 mg 3 zaug / hnub (rau kev kis mob me txog rau mob hnyav), lossis 1 ntsiav tshuaj 500 mg / 125 mg 3 zaug / hnub, lossis 1 ntsiav tshuaj 875 mg / 125 mg 2 zaug / hnub, lossis 11 ml ntawm kev ncua ntawm 400 mg / 57 mg / 5 ml 2 zaug / hnub (uas yog sib npaug rau 1 ntsiav tshuaj ntawm 875 mg / 125 mg).
- Ob ntsiav tshuaj 250 mg / 125 mg tsis sib npaug rau ib 500 ntsiav tshuaj / 125 mg ntsiav tshuaj.
- Cov menyuam yaus hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua li 40 kg. Cov tshuaj yog sau tseg hauv daim ntawv ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj. Kev suav qhov ntsuas yog ua raws li hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg lub cev qhov hnyav / hnub (xam raws li amoxicillin) lossis hauv ml ntawm kev ncua.
- Cov menyuam txij thaum yug mus txog 3 hlis. Vim lub cev tsis muaj nuj nqi ntawm qhov ua tau zoo tshaj plaws ntawm lub raum, qhov pom zoo koob tshuaj Augmentin (xam raws li amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj hauv daim ntawv 4: 1 ncua kev ncua.
Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub. Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob. Txhawm rau kom zoo thiab txo qis kev phiv los ntawm lub plab zom mov, Augmentin raug pom zoo kom noj thaum pib noj mov.
Augmentin thaum cev xeeb tub thiab lactation
Zoo li feem ntau cov tshuaj tua kab mob ntawm pawg penicillin, amoxicillin, muab faib rau hauv cov ntaub so ntswg ntawm lub cev, tseem nkag mus rau hauv niam cov kua mis. Ntxiv mus, kab qis ntau ntawm clavulanic acid tej zaum yuav pom nyob rau hauv cov mis nyuj.
Txawm li cas los xij, tsis muaj kev cuam tshuam loj hauv lub tsev kho mob los ntawm tus mob ntawm tus me nyuam yog sau tseg. Muaj qee kis, kev sib xyaw ntawm clavulanic acid nrog amoxicillin tuaj yeem ua rau mob raws plab thiab / lossis candidiasis (mob ntsws) ntawm cov qog ua kua rau hauv qhov ncauj kab noj hniav hauv menyuam.
Augmentin belongs rau cov qeb ntawm cov tshuaj pub mis pub mis. Yog tias, txawm li cas los xij, tiv thaiv keeb kwm ntawm niam txoj kev kho mob nrog Augmentin, tus me nyuam muaj qee qhov tshwm sim tsis zoo, kev pub mis niam yog tso tseg.
Augmentin's cov duab piv tau yog A-Clav-Farmex, Amoxiclav, Amoxil-K, Betaclav, Clavamitin, Medoclav, Teraclav npaj.
Xim: kev siv cov analogues yuav tsum pom zoo nrog tus kws kho mob koom.
Tus nqi nruab nrab ntawm Augmentin hauv khw muag tshuaj (Moscow) yog nyob ntawm daim ntawv tso tawm.
- Augmentin ntsiav tshuaj 250 mg + 125 mg, 20 pcs. - txij li 261 rub.
- Augmentin ntsiav tshuaj 500 mg + 125 mg, 14 pcs. - los ntawm 370 rub.
- Augmentin ntsiav tshuaj 875 mg + 125 mg, 14 pcs. - los ntawm 350 rub.
Cov lus thiab cov xwm txheej ntawm kev cia
Cov tshuaj yuav tsum muab cia rau hauv qhov chaw qhuav kom tsis txhob nkag tau rau cov menyuam yaus ntawm qhov kub tsis tshaj 25 ° C. Lub txee lub neej ntawm cov ntsiav tshuaj (250 mg + 125 mg) thiab (875 mg + 125 mg) yog 2 xyoos, thiab cov ntsiav tshuaj (500 mg + 125 mg) yog 3 xyoos. Lub txee lub neej ntawm cov hmoov rau kev npaj qhov kev ncua hauv lub raj mis tsis tau qhib yog 2 xyoos.
Qhov npaj ncua yuav tsum muab tso rau hauv tub yees ntawm qhov kub ntawm 2 ° txog 8 ° C rau 7 hnub.
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Tib neeg cov tawv nqaij ua mob: mob ntshav qab zib mellitus (duab thiab piav qhia)
Cov tawv nqaij ua mob rau cov ntshav qab zib mellitus: yees duab ntawm cov ntshav qab zib dermopathy Cov kab mob hloov pauv ntawm daim tawv nqaij yog raug ntsib los ntawm cov kws kho mob ntawm ntau yam tshwj xeeb, suav nrog endocrinologist. ... -
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