Analogs ntawm cov tshuaj langerin

Langerin yog ib qho ntawm ntau cov tshuaj noj tshuaj uas yog siv los kho tus txheej txheem pathological hu ua non-insulin-dependant ntshav qab zib mellitus. Cov tshuaj yog ib feem ntawm cov lag luam biguanide ntawm cov tshuaj, cov nyhuv tseem ceeb yog txo cov kev xav tau los ntawm kev tsim tshuaj insulin.

Tus nqi ntawm Langerin hauv cov khw muag tshuaj, nyob ntawm qhov yuav tsum tau ntau npaum li cas, tuaj yeem nyob ntawm ib puas txog peb puas rubles.

Langerin yog cov tshuaj noj hauv qhov ncauj uas siv los kho cov mob ntshav qab zib kom ntau. Nws lub ntsiab tivthaiv yog cov tshuaj metformin. Cov tshuaj yog ib cov tshuaj uas txo cov ntshav qab zib thiab feem ntau yog siv los kho cov ntshav qab zib kom tsawg hauv cov ntshav qab zib.

Ib qho ntawm cov tshuaj tuaj yeem tau txais ntawm cov tshuaj no yog nws txoj kev tswj hwm nyob rau hauv kev tsis muaj txiaj ntsig ntawm cov ntsiav tshuaj siv yav dhau los los ntawm sulfonylurea pawg. Ib qho ntxiv, kev rog dhau yog qhov teeb meem uas tsim teeb meem rau txhua tus neeg mob ntshav qab zib.

Yog vim li ntawd, Langerin tso cai tsis tsuas yog ua kom cov suab thaj qis dua, tab sis kuj tseem ua rau lub cev qeeb dua li qub ntawm tus neeg mob lub cev.

Tshuaj thaj tsob thiab cov cim rau kev siv

Lub tshuab nruab nrab ntawm kev ua ntawm qhov tseem ceeb ntawm cov tshuaj cuam tshuam nrog nws lub peev xwm los txwv cov txheej txheem ntawm gluconeogenesis, nrog rau cov txheej txheem ntawm kev ua ke ntawm cov roj ntsha dawb thiab ua kom muaj roj oxidation. Tus neeg sawv cev ntawm chav kawm biguanide tsis cuam tshuam rau qhov tshuaj insulin tso rau hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov insulin kom dawb thiab nce qhov feem ntawm insulin rau proinsulin.

Lub ntsiab lus tseem ceeb hauv cov txheej txheem ntawm kev nqis tes ntawm cov ntsiav tshuaj xws li yog qhov kev ua kom pom ntawm qabzib cov nqaij mob hlwb

Qhov tseem ceeb tshaj plaws rau kev siv tshuaj yog kev txhim kho ntawm cov tshuaj insulin-ntshav qab zib hauv ib tus neeg, tshwj xeeb tshaj yog nrog kev tsis muaj txiaj ntsig ntawm kev noj zaub mov ua raws.

Cov khoom tseem ceeb ntawm Langerin muaj xws li:

• txo cov ntshav glycated hemoglobinꓼ
• nruab nrab cov tshuaj insulin tsis ua haujlwm ntawm cov qe rau cov tshuaj hormones insulin
• favorably cuam tshuam qhov normalization ntawm lipid profile ntawm ntshav ntshav ꓼ
• txo cov roj (cholesterol) phem

Tsis tas li ntawd, kev siv cov tshuaj muaj peev xwm ua kom lub cev qhov hnyav.

Cov lus qhia rau kev siv ntsiav tshuaj

Cov tshuaj Langerin yog muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated.

Cov ntawv ntim rau hauv lub hnab yas, uas tau ntim nrog txhuas ntawv ci.

Cov ntim khoom tau muab tso rau hauv lub thawv ntawv thawv nrog cov lus qhia rau kev siv tshuaj.

Ua raws li qhov xav tau ntawm cov tshuaj tau siv, cov tshuaj tuaj yeem tuaj yeem yuav nrog ntau npaum li cas:

1. 500 milligrams.
2. 850 milligrams.
3. Ib qho ntawm cov tshuaj muaj zog.

Cov qauv ntawm kev noj cov ntsiav tshuaj yog qhov ncauj, ntawm lub sijhawm noj mov lossis tom qab nws. Tus kws kho mob uas tuaj koom yuav sau ib qho tshuaj rau txhua tus neeg mob nyob ntawm seb tus kab mob loj npaum li cas. Tsis tas li, tus kws kho mob tshwj xeeb txiav txim siab noj tshuaj ntau npaum li cas thaum nruab hnub.

Langerin-cov lus qhia rau kev siv pom zoo pib ib chav pov thawj ntawm kev kho mob nrog kev noj tshuaj tsawg kawg 500 mg ntawm cov tshuaj nquag. Tus naj npawb ntawm cov koob tshuaj ntawm lub tshuaj nruab hnub yuav ua tau li ntawm ib mus txog peb. Maj mam, ntau npaum li cas ntxiv tau nce rau 850 mg ntawm cov tshuaj nquag thoob plaws ib hnub (ib zaug ob zaug hauv ib hnub). Cov kws kho mob koom nrog saib xyuas qhov mob ntawm tus neeg mob thiab, tsis pub ntau tshaj ib zaug ib lim tiam, kho cov tshuaj ntawm cov tshuaj noj tau nce siab.

Cov tshuaj no tseem tau sau tseg txog kev kho mob rau tus menyuam hauv ntau tshaj kaum xyoo. Kev kho mob Monotherapy yuav tsum pib nrog kev noj tshuaj ntawm 500 mg ntawm cov tshuaj nquag ib zaug lossis ob zaug ib hnub. Tom qab qee lub sijhawm, maj mam nce ntxiv ntawm cov koob tshuaj tau tso cai, tab sis tsis pub ntau tshaj ob grams hauv ib hnub, muab faib ua ob lossis peb koob tshuaj.

Feem ntau, kev hloov pauv hauv cov ntau npaum li cas ntawm cov tshuaj tshwm sim tom qab kaum txog kaum tsib hnub raws li cov txiaj ntsig ntawm kev ntsuas ntshav rau cov piam thaj.

Qee qhov xwm txheej, kev npaj ntsiav tshuaj yog ib feem ntawm kev sib txuas ua ke nrog kev siv tshuaj insulin.

Nws yuav tsum raug sau tseg tias kev tswj hwm ib txhij ntawm Langerin nrog insulin, sulfonylurea derivatives, acarbose, lossis ACE inhibitors yog pom kom nce cov nyhuv hypoglycemic ntawm cov tshuaj.

Qee qhov xwm txheej, tus kws kho mob mus koom yuav hloov qhov kev siv Langerin nrog cov ntsiav tshuaj ntawm cov sib xws. Niaj hnub no, muaj tshuaj ntau ntau, lub ntsiab tseem ceeb ua ke ntawm uas yog metformin.

Tus nqi ntawm cov tshuaj analog tuaj yeem sib txawv, nyob ntawm seb lub tuam txhab ntawm cov chaw muag tshuaj.

Dab tsi yog cov contraindications rau siv?

Cov tshuaj noj tsis raug cai lossis tsis ua raws li cov lus pom zoo ntawm tus kws kho mob tuaj yeem ua rau pom kev phiv tshuaj tsis zoo thaum noj cov tshuaj.

Ntxiv rau, muaj qee kis hauv kev siv tshuaj yeeb tshuaj raws li metformin yog txwv tsis pub.

Cov lus qhia rau kev siv tshuaj qhia cov npe ntawm contraindications tseem ceeb.

Lub ntsiab contraindications rau kev siv ntawm Langerin ntsiav tshuaj suav nrog cov hauv qab no:

• kev ua rau mob siab lossis lub raum tsis ua haujlwm, lawv qhov tsis muaj txiaj ntsig ꓼ
• cawv, suav nrog nyob rau hauv mob ntev formꓼ
• mob plawv los yog kev ua pa tsis ua hauj lwm
• mob myocardial infarctionꓼ
• kev mob nkeeg uas tsis yog mob ntshav qab zib coma lossis poj koob yawm txwvꓼ
• kev loj hlob ntawm tus mob ko taw mob ko taw syndromeꓼ
• nyob rau hauv ib puag ncig ntawm ib tug neeg intolerance rau metformin thiab kev loj hlob ntawm kev tsis haum rau lub componentꓼ
• muaj cov kis mob sib kis-
• yoo mov nrog cov ntshav qab zib lossis ua raws li kev noj haus uas nws noj txhua hnub tsis pub dhau ib txhiab kilocaloriesꓼ
• ua ntej thiab tom qab phaisꓼ
• nrog cov kev raug mob uas tsis ntev los noꓼ
• ua ntej thiab tom qab kev kuaj mob uas siv lub xov tooj cua isotropes ntawm iodineꓼ
• ketoacidosis thiab mob lactic acidosis.

Ntxiv rau, cov poj niam yuav tsum tsis txhob noj cov tshuaj thaum cev xeeb tub thiab lactation.

Qhov tshwm sim ntawm kev mob tshwm sim tuaj yeem tshwm sim nws tus kheej rau ntawm ib feem ntawm ntau yam plab hnyuv siab raum thiab cov kab ke ntawm tib neeg lub cev - lub plab zom mov, metabolism, kab mob plawv, kab mob ntawm daim tawv nqaij. Cov kev tshwm sim tsis zoo uas tshwm sim los ntawm kev noj tshuaj yog:

1. Txhawb siab flatulence. Qee zaum xeev siab tshwm sim hauv ntshav qab zib hom 2. Xeev siab yuav hloov los ntuav.
2. Kev mob plab mog.
3. Cov tsos ntawm cov xim hlau sib xyaw hauv qhov ncauj kab noj hniav.
4. Hematopoiesis thiab hemostasis.
5. Megaloblastic anemia.
6. Txo cov ntshav qab zib kom qis dua cov qib uas siv tau - hypoglycemia.
7. Cov tsos ntawm tsis muaj zog hauv lub cev.
8. Kev nkees nkees.
9. Kev Ntshav.
10. Kev ua pa ntawm lub siab.
11. Cov tsos ntawm dermatitis lossis ua pob rau ntawm daim tawv nqaij.

Ceev faj yuav tsum tau noj thaum noj Langerin nrog lwm cov tshuaj. Kev siv ua ke nrog cov ntsiav tshuaj nrog cymeditine nce kev pheej hmoo ntawm cov kab mob lactic acidosis. Kev sib xyaw ntawm Langerin nrog lub voj diuretics tuaj yeem txhim kho tib lub txiaj ntsig. Hauv qhov no, ntxiv rau qhov ua rau muaj kev tawm tsam ntawm cov kab mob lactic acidosis, ib qho kev pom ntawm lub raum tsis ua haujlwm tuaj yeem pom.

Siv cov tshuaj, nws yog ib qho tsim nyog los saib xyuas kev ua haujlwm ntawm lub raum thiab txiav txim siab cov lactate hauv ntshav tsawg kawg ob zaug hauv ib xyoos.

Cov lus qhia txog cov tshuaj siv los kho ntshav qab zib tau muab tso rau hauv cov yeeb yaj kiab hauv tsab xov xwm no.

Qhia txog ntawm cov tshuaj

Looj Yaj - Tus neeg sawv cev ntawm lub qhov ncauj hypoglycemic los ntawm cov pab pawg ntawm biguanides (dimethylbiguanide). Tus txheej txheem ntawm kev ua ntawm metformin yog txuam nrog nws lub peev xwm los txwv gluconeogenesis, nrog rau kev tsim cov roj dawb dawb thiab oxidation ntawm cov rog. Tsub qhov rhiab heev ntawm peripheral receptors rau insulin thiab kev siv cov kua nplaum los ntawm lub hlwb. Metformin tsis cuam tshuam rau cov tshuaj insulin hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov insulin kom dawb thiab nce qhov feem ntawm cov insulin rau proinsulin.

Metformin stimulates glycogen synthesis los ntawm kev ua ntawm glycogen synthetase. Tsub kom muaj peev xwm thauj tau txhua yam ntawm cov khoom thauj ua kua roj ntau dua. Ncua kev nqus cov hnyuv ntawm lub ntsej muag.

Txo cov qib triglycerides, LDL, VLDL. Metformin kho txhim kho cov khoom fibrinolytic ntawm cov ntshav los ntawm kev tiv thaiv cov nqaij mos-plasminogen activator inhibitor.

Thaum noj cov tshuaj metformin, tus neeg mob lub cev hnyav dua li qub tseem ruaj khov lossis txo qis.

Sau cov analogues

Cov khoom txaus nyiam

Yuav ua li cas xaiv txoj cai piv rau
Hauv khw muag tshuaj, tshuaj feem ntau muab faib ua cov lus ua kom sib piv thiab cov duab analogues. Cov txheej txheem ntawm cov lus txhais suav nrog ib los yog ntau qhov kev dhia tshuaj qub uas muaj kev kho lub cev. Los ntawm cov qauv piv txwv yog cov tshuaj uas muaj cov tshuaj sib txawv, tab sis npaj rau kev kho mob ntawm tib cov kab mob.

Qhov sib txawv ntawm cov kis thiab kab mob
Cov kab mob kis tau yog tshwm sim los ntawm cov kab mob, kab mob, hu ua fungi thiab protozoa. Cov chav kawm ntawm kab mob tshwm sim los ntawm cov kab mob thiab cov kab mob feem ntau zoo sib xws. Txawm li cas los xij, kom paub qhov txawv ntawm qhov ua rau tus mob txhais tau tias xaiv qhov kev kho mob uas yuav pab tau sai sai nrog qhov malaise thiab yuav tsis ua mob rau tus menyuam.

Kev ua xua yog qhov ua rau mob khaub thuas
Qee tus neeg tau paub txog qhov xwm txheej uas tus menyuam yaus nyob ntev thiab ntau lub sijhawm muaj tus mob khaub thuas. Cov niam txiv coj nws mus rau cov kws kho mob, ua cov kev xeem, siv tshuaj, thiab vim li ntawd, tus me nyuam twb sau npe nrog kws kho mob raws li feem ntau mob. Qhov tseeb uas ua rau mob ntsws ua pa heev tsis txheeb xyuas.

Txoj hlab zis: kho mob chlamydial urethritis
Chlamydial urethritis feem ntau pom muaj nyob ntawm txoj kev siv ntawm urologist. Nws tshwm sim los ntawm tus kab mob intracellular parasite Chlamidia trachomatis, uas muaj cov khoom ntawm ob hom kab mob thiab kab mob, uas feem ntau xav tau cov tshuaj tua kab mob ntev mus rau kev siv tshuaj tua kab mob. Nws muaj peev xwm ua rau tsis muaj qhov mob tshwj xeeb ntawm txoj hlab zis rau txiv neej thiab poj niam.

Langerin - cov lus qhia rau kev siv, nqi, xyuas

Cov nplooj ntawv muab cov ntaub ntawv hais txog yeeb tshuaj Langerin - cov lus qhia raug nthuav tawm ua lus txhais pub dawb. Yog xav paub meej ntau, thov hu rau lub tuam txhab cov lus cim. Muaj cov lus qhia rau cov tshuaj tsis yog thaj chaw rau tus kheej tshuaj.

Chaw tsim tshuaj paus: Zentiva a.s (Cov koom pheej Slovak)

Yam tshuaj muaj yees
Chav kawm ntawm cov kab mob

• Tsis-insulin-mob ntshav qab zib mellitus

Cov chaw soj ntsuam thiab chaw muag tshuaj

• Tsis teev. Saib cov lus qhia

Pharmacological kev txiav txim
Pharmacological pawg

• Hypoglycemic hluavtaws thiab lwm tus neeg sawv cev hauv kev sib txuas

Tso daim foos Langerin

500 mg zaj duab xis-ntsiav tshuaj, blister ntim 10 pob ntawm cardboard 6 pob, 500 ntsiav tshuaj zaj duab xis-ntsiav tshuaj, blister ntim 10 ntim 10 ntim ntawm cardboard 3, 500 mg zaj duab xis-ntsiav tshuaj, blister ntim 10 pob ntawm cardboard 9, tshuaj, 850 mg zaj duab xis-txheej, hlwv ntim 10 pob ntawm cardboard 6, ntsiav tshuaj, 850 mg zaj duab xis-blister ntim, 850 mg zaj duab xis blister pob, 10 ntim ntawm cardboard pob 3, zaj duab xis-coated ntsiav tshuaj 850 mg, blister pob 10 ntim ntawm cardboard 9, ntsiav tshuaj coated nrog zaj duab xis txheej 1 g, sawv hlwv pob 10 ntim ntawm cardboard 1, ntsiav tshuaj coated nrog zaj duab xis plhaub 1 g, sawv hlwv ntim 10 ntim ntawm cardboard 3, ntsiav tshuaj coated nrog zaj duab xis plhaub 1 g, sawv hlwv pob 10 pob ntawv cardboard 9,

ntsiav tshuaj coated nrog zaj duab xis txheej ntawm 1 g, sawv hlwv ntim 10 ntim ntawm cardboard 6,

Cov Tshuaj Hauv Tshuaj

Txo cov concentration ntawm cov piam thaj (ntawm lub plab khoob thiab tom qab noj mov) hauv cov ntshav thiab qib ntawm glycosylated hemoglobin, ua rau muaj kev tiv thaiv ntshav qabzib ntau dua. Txo cov hnyuv nqus ntawm cov piam thaj, nws cov khoom lag luam tawm hauv lub siab, potentiates insulin rhiab heev hauv cov ntaub so ntswg (thaj chaw piam thaj thiab nws cov metabolism nce ntxiv).

Tsis hloov cov tshuaj insulin tso tawm los ntawm beta hlwb ntawm pancreatic islets (qib insulin ntsuas ntawm lub plab khoob thiab cov lus teb insulin txhua hnub kuj tseem yuav txo qis).

Nws normalizes lipid profile ntawm cov ntshav plasma hauv cov neeg mob uas tsis muaj ntshav qab zib tsis yog insulin-mob ntshav qab zib mellitus: nws txo cov ntsiab lus ntawm triglycerides, cov roj (cholesterol) thiab LDL (txiav txim siab ntawm lub plab khoob) thiab tsis hloov cov qib ntawm lipoproteins ntawm lwm qhov uas raug mob. Stabilizes lossis txo qhov hnyav lub cev.

Cov Tshuaj Pharmacokinetics

Sai sai nqus los ntawm cov hnyuv. Kev tsis txaus siab txog kev noj qab haus huv (ntawm lub plab khoob) yog 50-60%. Cmax hauv ntshav tau txog tom qab 2 teev. Noj tsawg Cmax los ntawm 40% thiab ua rau nws ua tiav qeeb los ntawm 35 feeb.

Qhov sib luag siab ntawm metformin hauv cov ntshav tau mus txog hauv 24–48 teev tsis dhau 1 exceedg / ml. Qhov ntim ntawm kev faib khoom (rau ib koob tshuaj 850 mg) yog (654 ± 358) l. Tsawg me ntsis khi rau cov ntshav plasma protein, muaj peev xwm mus sib sau hauv cov salivary qog, mob siab thiab ob lub raum.

Nws yog tawm los ntawm lub raum (feem ntau los ntawm tubular tso zis) tsis hloov (90% hauv ib hnub). Lub raum Cl - 350-550 ml / min. T1 / 2 yog 6.2 h (ntshav) thiab 17.6 h (ntshav) (qhov sib txawv yog vim muaj peev xwm sib sau hauv cov ntshav liab).

Hauv cov neeg laus, T1 / 2 ncua sijhawm thiab Cmax nce. Yog tias lub raum tsis ua haujlwm, T1 / 2 lengthens thiab lub raum tshem tawm tsawg.

Thaum lub sijhawm kho yuav tsum tsis pub niam mis rau menyuam noj.

Cov Yuav Tsum Muaj

Kev kub siab lub cev, lub raum, lossis lub raum tsis ua haujlwm (cov yeeb yam tsim muaj ntau dua 0.132 mmol / L hauv cov txiv neej thiab 0.123 mmol / L hauv cov poj niam), mob siab ua rau lub siab tsis ua haujlwm, mob nrog hypoxia

mob plawv thiab ua pa tsis ua haujlwm, mob myocardial infarction, mob hlwb tsis txaus, lub cev tsis txaus, ua kom lub cev qhuav dej, muaj kab mob kis, ua haujlwm ntau thiab raug mob, kev haus cawv ntev, mob ntev lossis mob metabolic acidosis, suav nrog ketoacidosis uas mob ntshav qab zib nrog lossis tsis nco qab, keeb kwm ntawm cov kab mob lactic acidosis kev ua raws li kev noj zaub mov kom tsis txhob muaj kuab tsawg (tsawg dua 1000 kcal / hnub), kev tshawb fawb siv hluav taws xob iodine isotopes, cev xeeb tub, pub niam mis.

Sab sij huam

Los ntawm cov mob plab zom mov: thaum pib ntawm txoj kev kho mob - tsis nco qab, zawv plab, xeev siab, ntuav, mob plab, mob plab (poob nrog zaub mov), nws yog xim hlau saj hauv lub qhov ncauj (3%).

Los ntawm ib sab ntawm cov hlab plawv thiab ntshav (hematopoiesis, hemostasis): hauv qee qhov mob tsawg - megaloblastic anemia (tshwm sim ntawm malabsorption ntawm vitamin B12 thiab folic acid).

Los ntawm ib sab ntawm cov metabolism: hypoglycemia, nyob rau hauv cov xwm txheej tsawg - lactic acidosis (tsis muaj zog, tsaug zog, hypotension, tiv taus bradyarrhythmia, ua pa tsis meej pem, mob plab, myalgia, hypothermia).

Los ntawm daim tawv nqaij: ua pob, ua pob khaus.

Kev cuam tshuam nrog lwm yam tshuaj

Cov nyhuv ntawm metformin yog qaug zog los ntawm thiazide thiab lwm cov diuretics, corticosteroids, phenothiazines, glucagon, cov thyroid hormones, estrogens, suav nrog ua ib feem ntawm kev tiv thaiv kab mob hauv qhov ncauj, phenytoin, nicotinic acid, sympathomimetics, calcium antagonists, isoniazid.

Hauv tib lub koob tshuaj hauv cov neeg tuaj yeem noj qab haus huv, nifedipine nce kev nqus, Cmax (20%), AUC (9%) metformin, Tmax thiab T1 / 2 tsis hloov. Cov nyhuv rau hypoglycemic yog muaj zog los ntawm insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Kev tshawb nrhiav ntawm kev noj tshuaj ib zaug hauv cov neeg tuaj yeem noj qab haus huv pom tau tias furosemide nce Cmax (los ntawm 22%) thiab AUC (los ntawm 15%) ntawm metformin (tsis muaj qhov hloov pauv tseem ceeb ntawm kev tshem tawm ntawm metformin), metformin txo Cmax (los ntawm 31%), AUC (los ntawm 12 %) thiab T1 / 2 (32%) ntawm furosemide (tsis muaj qhov hloov pauv tseem ceeb ntawm kev kho lub plab ntawm furosemide).

Tsis muaj cov ntaub ntawv hais txog kev cuam tshuam ntawm metformin thiab furosemide nrog kev siv ntev. Tshuaj (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin) zais cia rau hauv cov tubules sib tw rau tubular thauj cov tshuab thiab tuaj yeem nce Cmax ntawm metformin los ntawm 60% nrog kev kho mob ntev.

Cimetidine qeeb qeeb ntawm kev txiav tawm cov metformin, uas ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob lactic acidosis. Tsis sib xyaw nrog cawv (muaj kev pheej hmoo ntawm kev tsim cov kua mis acidosis).

Cov haujlwm ua haujlwm raum, glomerular pom, thiab ntshav qab zib yuav tsum tau soj ntsuam tas li. Tshwj xeeb tshaj yog ua tib zoo saib xyuas cov ntshav qabzib hauv cov ntshav yog qhov tsim nyog thaum siv metformin ua ke nrog sulfonylureas lossis insulin (muaj kev pheej hmoo ntawm cov ntshav qab zib).

Ua ke nrog kev kho mob nrog metformin thiab insulin yuav tsum tau nqa tawm hauv tsev kho mob kom txog thaum tsim nyog ib koob tshuaj ntawm txhua cov tshuaj tsim. Hauv cov neeg mob ntawm kev kho mob tas mus li nrog metformin, nws yog qhov yuav tsum tau txiav txim siab cov ntsiab lus ntawm cov vitamin B12 ib xyoos ib zaug vim muaj qhov txo qis hauv nws qhov nqus tau.

Nws yog qhov tsim nyog los txiav txim siab txog qib ntawm lactate hauv ntshav tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia. Nrog rau qhov nce ntxiv ntawm cov ntsiab lus lactate, cov tshuaj raug muab tso tseg.

Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua tiav, nrog rau 2 hnub ua ntej thiab tom qab kuaj mob (tshuaj mob ntawm urography, angiography, thiab lwm yam).

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

10 Pcs. - blisters (3) - pob khoom ntawm cardboard. 10 pcs. - hlwv (6) - pob khoom los ntawm cardboard.

10 Pcs. - hlwv (9) - pob khoom los ntawm cardboard.

Pharmacological kev txiav txim

Qhov ncauj hypoglycemic tus neeg sawv cev los ntawm pab pawg ntawm biguanides (dimethylbiguanide). Tus txheej txheem ntawm kev ua ntawm metformin yog txuam nrog nws lub peev xwm los txwv gluconeogenesis, nrog rau kev tsim cov roj dawb dawb thiab oxidation ntawm cov rog.

Metformin tsis cuam tshuam rau cov tshuaj insulin hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov insulin kom dawb thiab nce qhov feem ntawm cov insulin rau proinsulin.

Qhov kev sib txuas tseem ceeb hauv cov txheej txheem ntawm kev ua ntawm metformin yog qhov kev xav ntawm cov piam thaj los ntawm cov leeg nqaij.

Metformin txhim kho cov ntshav ncig hauv lub siab thiab ua kom nrawm hloov pauv ntawm cov piam thaj rau glycogen. Txo cov qib triglycerides, LDL, VLDL. Metformin kho txhim kho cov khoom fibrinolytic ntawm cov ntshav los ntawm kev tiv thaiv cov nqaij mos-plasminogen activator inhibitor.

Hom 1 mob ntshav qab zib mellitus (insulin-dependant) - nrog lub hom phiaj ntawm kev txo qis qhov xav tau ntawm insulin thiab tiv thaiv qhov hnyav ntxiv (ntxiv rau kev kho mob insulin).

Hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) thaum tsis muaj txiaj ntsig kev noj zaub mov zoo (tshwj xeeb tshaj yog rau cov rog rog).

Kev noj tshuaj ntxiv

Rau cov neeg mob tsis tau txais insulin, hauv thawj 3 hnub - 500 mg 3 zaug / hnub lossis 1 g 2 zaug / hnub thaum lossis tom qab noj mov. Txij hnub tim 4 mus txog rau hnub 14 - 1 g 3 zaug / hnub. Tom qab 15 hnub, qhov hno tshuaj tau raug hloov kho mus rau hauv tus account qib ntawm cov piam thaj hauv cov ntshav thiab zis. Kev saib xyuas qhov koob tshuaj yog 100-200 mg / hnub.

Nrog rau kev siv tshuaj insulin ib txhij ntawm ib koob tsawg dua 40 units / hnub, kev noj tshuaj ntawm cov tshuaj metformin yog qhov qub, thaum lub koob tshuaj insulin tuaj yeem maj mam txo qis (los ntawm 4-8 units / hnub txhua lwm hnub). Yog tias tus neeg mob tau txais ntau dua 40 units / hnub, tom qab ntawd kev siv cov metformin thiab txo qis ntawm cov tshuaj insulin yuav tsum muaj kev saib xyuas zoo thiab raug coj hauv tsev kho mob.

Analogs thiab cov nqi tshuaj Langerin

film-coated ntsiav tshuaj

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

film-coated ntsiav tshuaj

txheej ntsiav tshuaj

txhawb nqa cov ntsiav tshuaj

txhawb nqa cov ntsiav tshuaj

film-coated ntsiav tshuaj

film-coated ntsiav tshuaj

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

film-coated ntsiav tshuaj

zaj duab xis-txheej pab raws li tso ntsiav tshuaj

txhawb nqa cov ntsiav tshuaj

txhawb nqa cov ntsiav tshuaj

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

Tag nrho cov npav: 73 tus kws kho mob.

Cov ntsiab lus ntawm cov neeg teb los ntawm kev tshwj xeeb:

Sab sij huam

Los ntawm lub plab zom mov: ua tau (feem ntau thaum pib kev kho mob) xeev siab, ntuav, raws plab.

Los ntawm cov kab ke endocrine: hypoglycemia (feem ntau yog siv nyob rau hauv cov koob tshuaj tsis tsim nyog).

Los ntawm sab ntawm cov metabolism: Hauv qee kis - lactic acidosis (yuav tsum muaj cessation ntawm kev kho mob).

Los ntawm cov kab ke hemopoietic: hauv qee kis - megaloblastic anemia.

Cov lus qhia tshwj xeeb

Nws tsis pom zoo rau mob hnyav, dhau mus ua kab mob sib kis thiab mob o, raug mob, mob phais mob sai, thiab muaj kev puas tsuaj ntawm lub cev qhuav dej.

Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua.

Nws tsis pom zoo kom siv cov metformin hauv cov neeg mob hnub nyoog tshaj 60 xyoo thiab cov neeg ua haujlwm hnyav lub cev, uas cuam tshuam nrog kev pheej hmoo ntawm kev tsim mob lactic acidosis.

Thaum kho, nws yog ib qho tsim nyog los saib xyuas lub raum kev ua haujlwm, qhov kev txiav txim siab ntawm cov ntsiab lus lactate hauv ntshav yuav tsum tau nqa tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia.

Metformin tuaj yeem siv ua ke nrog sulfonylureas. Hauv qhov no, tshwj xeeb tshaj yog saib xyuas cov ntshav ntshav qab zib kom tsim nyog.

Kev siv cov metformin ua ib feem ntawm kev sib xyaw ua ke nrog kev siv tshuaj insulin yog raug pom zoo hauv tsev kho mob.

Yeeb tshuaj sib cuam tshuam

Nrog tib lub sijhawm siv nrog sulfonylurea derivatives, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, nrog clofibrate, cyclophosphamide, cov nyhuv hypoglycemic ntawm metformin tej zaum yuav ua kom zoo dua.

Nrog rau kev siv ua ke nrog GCS, tshuaj tiv thaiv qog rau kev tswj hwm qhov ncauj, adrenaline, glucagon, cov thyroid hormones, phenothiazine derivatives, thiazide diuretics, nicotinic acid derivatives, txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Kev siv cov cimetidine ntau heev yuav ua rau muaj kev pheej hmoo ntawm tus mob lactic acidosis.

37. : 2.92)
Chaw thau khoom ...

Cov Lus Qhia LANGERIN (LANAGERIN)

ATX Cov Cai: A10BA02

Metformin yog nqus los ntawm cov hnyuv plab. Cmax hauv ntshav tau txog li 2 teev tom qab kev noj mov. Tom qab 6 teev, kev nqus ntawm lub plab zom mov tag thiab qhov ua kom zoo ntawm metformin hauv cov ntshav qis zuj zus.Qhov kev siv tsis khi rau cov plasma protein. Nws nthuav tawm hauv lub qog ua kua qaub ncaug, mob siab thiab lub raum T1 / 2 - 1.5-4.5 teev. Nws raug tso tawm los ntawm lub raum.Yog li ntawm lub raum tsis ua haujlwm, metformin tuaj yeem tsim tawm.

Yuav LANGERINE

Yuav tus nqi tsawg kawg:

Peb cov qhua tuaj yeem ua tsaug rau koj yog tias koj sau hauv qhov chaw muag tshuaj online koj tau pom zoo tshaj plaws.

Ntsuam xyuas ntawm cov neeg tuaj xyuas ntawm qhov ntsuas ntawm "nqi / ua tau zoo": 37. : 2.92)
Chaw thau khoom ...

Yog tias koj tau siv cov tshuaj LANZHERIN (LANAGERIN), tsis txhob ua tub nkeeg los ntawm koj qhov tshuaj xyuas txog kev siv tshuaj. Nws raug nquahu kom ntsuas LANGERINE los ntawm tsawg kawg ob qhov ntsuas: tus nqi thiab qhov ua haujlwm. Koj yuav pab tau lwm tus yog tias koj qhia tias tus kab mob tau tsim tawm los ntawm cov tshuaj.

Langerin - qhia txog cov tshuaj, cov lus qhia siv, tshuaj xyuas - Lub portal kho mob

Sau ntawv rov los saib dua
1 tshuaj xyuas

Chaw tsim tshuaj paus: Zentiva a.s (Cov koom pheej Slovak)

Yam tshuaj muaj yees

Chav kawm ntawm cov kab mob

• Tsis-insulin-mob ntshav qab zib mellitus

Cov chaw soj ntsuam thiab chaw muag tshuaj

• Tsis teev. Saib cov lus qhia

Pharmacological kev txiav txim

Pharmacological pawg

• Hypoglycemic hluavtaws thiab lwm tus neeg sawv cev hauv kev sib txuas

Siv thaum cev xeeb tub

Thaum cev xeeb tub, nws muaj peev xwm yog tias qhov xav tau ntawm kev kho mob ntau dhau qhov kev pheej hmoo rau tus me nyuam hauv plab (kev tshawb fawb txaus thiab nruj me ntsis ntawm kev siv thaum cev xeeb tub tsis tau ua).

FDA qeb ntawm kev nqis tes ua rau tus menyuam yog B.

Thaum lub sijhawm kho yuav tsum tsis pub niam mis rau menyuam noj.

Kev sib cuam tshuam nrog lwm yam tshuaj

Cov nyhuv ntawm metformin yog qaug zog los ntawm thiazide thiab lwm cov diuretics, corticosteroids, phenothiazines, glucagon, cov thyroid hormones, estrogens, suav nrog ua ib feem ntawm kev tiv thaiv kab mob hauv qhov ncauj, phenytoin, nicotinic acid, sympathomimetics, calcium antagonists, isoniazid.

Hauv tib lub koob tshuaj hauv cov neeg tuaj yeem noj qab haus huv, nifedipine nce kev nqus, Cmax (20%), AUC (9%) metformin, Tmax thiab T1 / 2 tsis hloov.

Cov nyhuv rau hypoglycemic yog muaj zog los ntawm insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Kev tshawb nrhiav ntawm kev noj tshuaj ib zaug hauv cov neeg tuaj yeem noj qab haus huv pom tau tias furosemide nce Cmax (los ntawm 22%) thiab AUC (los ntawm 15%) ntawm metformin (tsis muaj qhov hloov pauv tseem ceeb ntawm kev tshem tawm ntawm metformin), metformin txo Cmax (los ntawm 31%), AUC (los ntawm 12 %) thiab T1 / 2 (32%) ntawm furosemide (tsis muaj qhov hloov pauv tseem ceeb ntawm kev kho lub plab ntawm furosemide). Tsis muaj cov ntaub ntawv hais txog kev cuam tshuam ntawm metformin thiab furosemide nrog kev siv ntev. Tshuaj (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin) zais cia rau hauv cov tubules sib tw rau tubular thauj cov tshuab thiab tuaj yeem nce Cmax ntawm metformin los ntawm 60% nrog kev kho mob ntev. Cimetidine qeeb qeeb ntawm kev txiav tawm cov metformin, uas ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob lactic acidosis. Tsis sib xyaw nrog cawv (muaj kev pheej hmoo ntawm kev tsim cov kua mis acidosis).

Cov kev ceev faj rau kev siv

Cov haujlwm ua haujlwm raum, glomerular pom, thiab ntshav qab zib yuav tsum tau soj ntsuam tas li. Tshwj xeeb tshaj yog ua tib zoo saib xyuas cov ntshav qabzib hauv cov ntshav yog qhov tsim nyog thaum siv metformin ua ke nrog sulfonylureas lossis insulin (muaj kev pheej hmoo ntawm cov ntshav qab zib).

Ua ke nrog kev kho mob nrog metformin thiab insulin yuav tsum tau nqa tawm hauv tsev kho mob kom txog thaum tsim nyog ib koob tshuaj ntawm txhua cov tshuaj tsim. Hauv cov neeg mob ntawm kev kho mob tas mus li nrog metformin, nws yog qhov yuav tsum tau txiav txim siab cov ntsiab lus ntawm cov vitamin B12 ib xyoos ib zaug vim muaj qhov txo qis hauv nws qhov nqus tau.

Nws yog qhov tsim nyog los txiav txim siab txog qib ntawm lactate hauv ntshav tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia. Nrog rau qhov nce ntxiv ntawm cov ntsiab lus lactate, cov tshuaj raug muab tso tseg.

Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua tiav, nrog rau 2 hnub ua ntej thiab tom qab kuaj mob (tshuaj mob ntawm urography, angiography, thiab lwm yam).

Zoo ib yam tshuaj:

** Qhia Txog Kev Siv Tshuaj Kho Mob yog rau cov lus qhia xwb. Xav paub ntau ntxiv, thov hu rau cov khw muag khoom ntim muag.

Tsis txhob noj tshuaj rau tus kheej, ua ntej koj pib siv Langerin, koj yuav tsum sab laj nrog kws kho mob. EUROLAB tsis yog lub luag haujlwm rau lub txim vim tshwm sim los ntawm kev siv cov ntaub ntawv tshaj tawm ntawm lub portal.

Txhua yam ntaub ntawv ntawm lub vev xaib tsis hloov cov kws kho mob cov lus qhia thiab tsis tuaj yeem ua lub luag haujlwm ntawm lub luag haujlwm zoo ntawm cov tshuaj.

Koj puas nyiam ua Langerin? Koj puas xav paub cov ncauj lus ntxaws ntxaws lossis koj puas xav ntsib kws kho mob? Los yog koj puas xav tau kev kuaj xyuas? Koj ua tau teem sijhawm nrog tus kws kho mob - chaw kho mob Eurolab ib txwm nyob ntawm koj qhov kev pabcuam! Cov kws kho mob zoo tshaj plaws yuav tshuaj xyuas koj, tawm tswv yim, muab kev pabcuam tsim nyog thiab ua kev kuaj mob. Koj tuaj yeem ua tau hu kws kho mob tom tsevCov. Cov chaw kho mob Eurolab qhib rau koj ib ncig ntawm lub moos.

** Mloog! Cov lus qhia hauv phau ntawv qhia tshuaj no yog npaj rau cov kws kho mob thiab tsis yog lub hauv paus rau kev siv tus kheej. Cov lus piav qhia txog cov tshuaj Langerin tau muab rau cov ncauj lus thiab tsis yog tsim los sau kev kho mob yam tsis muaj kev koom tes los ntawm kws kho mob. Cov neeg mob xav tau tswv yim tshwj xeeb!

Cev xeeb tub thiab lactation

Contraindicated nyob rau hauv cev xeeb tub thiab lactation.

Siv rau lub siab ua haujlwm tsis zoo

Ua rau lub siab ua rau lub siab ua haujlwm tsis zoo.

Siv rau lub raum tsis zoo muaj nuj nqi

Contraindicated nyob rau hauv lub raum loj puas.

Siv rau lub sijhawm qub

Metformin tsis pom zoo rau cov neeg mob hnub nyoog 60 xyoo, uas yog txuam nrog kev pheej hmoo ntawm cov kab mob lactic acidosis.

Cov lus qhia tshwj xeeb

Nws tsis pom zoo rau mob hnyav, dhau mus ua kab mob sib kis thiab mob o, raug mob, mob phais mob sai, thiab muaj kev puas tsuaj ntawm lub cev qhuav dej.

Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua.

Nws tsis pom zoo kom siv cov metformin hauv cov neeg mob hnub nyoog tshaj 60 xyoo thiab cov neeg ua haujlwm hnyav lub cev, uas cuam tshuam nrog kev pheej hmoo ntawm kev tsim mob lactic acidosis.

Thaum kho, nws yog ib qho tsim nyog los saib xyuas lub raum kev ua haujlwm, qhov kev txiav txim siab ntawm cov ntsiab lus lactate hauv ntshav yuav tsum tau nqa tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia.

Metformin tuaj yeem siv ua ke nrog sulfonylureas. Hauv qhov no, tshwj xeeb tshaj yog saib xyuas cov ntshav ntshav qab zib kom tsim nyog.

Kev siv cov metformin ua ib feem ntawm kev sib xyaw ua ke nrog kev siv tshuaj insulin yog raug pom zoo hauv tsev kho mob.

Yeeb tshuaj sib cuam tshuam

Nrog tib lub sijhawm siv nrog sulfonylurea derivatives, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, nrog clofibrate, cyclophosphamide, cov nyhuv hypoglycemic ntawm metformin tej zaum yuav ua kom zoo dua.

Nrog rau kev siv ua ke nrog GCS, tshuaj tiv thaiv qog rau kev tswj hwm qhov ncauj, adrenaline, glucagon, cov thyroid hormones, phenothiazine derivatives, thiazide diuretics, nicotinic acid derivatives, txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Kev siv cov cimetidine ntau heev yuav ua rau muaj kev pheej hmoo ntawm tus mob lactic acidosis.

37. : 2.92)
Chaw thau khoom ...

Cov Lus Qhia LANGERIN (LANAGERIN)

ATX Cov Cai: A10BA02

Metformin yog nqus los ntawm cov hnyuv plab. Cmax hauv ntshav tau txog li 2 teev tom qab kev noj mov. Tom qab 6 teev, kev nqus ntawm lub plab zom mov tag thiab qhov ua kom zoo ntawm metformin hauv cov ntshav qis zuj zus.Qhov kev siv tsis khi rau cov plasma protein. Nws nthuav tawm hauv lub qog ua kua qaub ncaug, mob siab thiab lub raum T1 / 2 - 1.5-4.5 teev. Nws raug tso tawm los ntawm lub raum.Yog li ntawm lub raum tsis ua haujlwm, metformin tuaj yeem tsim tawm.

Cov lus qhia rau kev siv

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

10 Pcs. - blisters (3) - pob khoom ntawm cardboard. 10 pcs. - blisters (6) - pob khoom ntawm cardboard. 10 pcs. - hlwv (9) - pob khoom los ntawm cardboard.

cov ntsiav tshuaj ua yeeb yaj kiab, 850 mg: 30, 60 lossis 90 pcs. - LSR-003625/10, 04.30.10

Rau cov neeg mob tsis tau txais insulin, hauv thawj 3 hnub - 500 mg 3 zaug ib hnub. lossis 1 g 2 zaug ib hnub. lub sijhawm lossis tomqab noj mov. Hnub 4 nws mus txog rau hnub 14 - 1 g 3 zaug nyob rau ib hnub. Tom qab 15 hnub, qhov hno tshuaj tau raug hloov kho mus rau hauv tus account qib ntawm cov piam thaj hauv cov ntshav thiab zis. Kev saib xyuas txij nkawm yog 100-200 mg / hnub.

Nrog rau kev siv tshuaj insulin ib txhij hauv ib koob uas tsawg dua 40 units / hnub. qhov tshuaj ntau npaum li cas ntawm metformin yog qhov zoo ib yam, thaum cov koob tshuaj insulin tuaj yeem txo qis dua (los ntawm 4-8 units / hnub. txhua lwm hnub). Yog tias tus neeg mob tau txais ntau dua 40 units / hnub, tom qab ntawd kev siv cov metformin thiab txo qis ntawm cov tshuaj insulin yuav tsum muaj kev saib xyuas zoo thiab raug coj hauv tsev kho mob.

Cev xeeb tub thiab lactation

Contraindicated nyob rau hauv cev xeeb tub thiab lactation.

Yuav LANGERINE

Yuav tus nqi tsawg kawg:

Peb cov qhua tuaj yeem ua tsaug rau koj yog tias koj sau hauv qhov chaw muag tshuaj online koj tau pom zoo tshaj plaws.

Ntsuam xyuas ntawm cov neeg tuaj xyuas ntawm qhov ntsuas ntawm "nqi / ua tau zoo": 37. : 2.92)
Chaw thau khoom ...

Yog tias koj tau siv cov tshuaj LANZHERIN (LANAGERIN), tsis txhob ua tub nkeeg los ntawm koj qhov tshuaj xyuas txog kev siv tshuaj. Nws raug nquahu kom ntsuas LANGERINE los ntawm tsawg kawg ob qhov ntsuas: tus nqi thiab qhov ua haujlwm. Koj yuav pab tau lwm tus yog tias koj qhia tias tus kab mob tau tsim tawm los ntawm cov tshuaj.

Langerin: tshuaj xyuas txog cov tshuaj, nqe, lus qhia

Langerin yog ib qho ntawm ntau cov tshuaj noj tshuaj uas yog siv los kho tus txheej txheem pathological hu ua non-insulin-dependant ntshav qab zib mellitus. Cov tshuaj yog ib feem ntawm cov lag luam biguanide ntawm cov tshuaj, cov nyhuv tseem ceeb yog txo cov kev xav tau los ntawm kev tsim tshuaj insulin.

Tus nqi ntawm Langerin hauv cov khw muag tshuaj, nyob ntawm qhov yuav tsum tau ntau npaum li cas, tuaj yeem nyob ntawm ib puas txog peb puas rubles.

Langerin yog cov tshuaj noj hauv qhov ncauj uas siv los kho cov mob ntshav qab zib kom ntau. Nws lub ntsiab tivthaiv yog cov tshuaj metformin. Cov tshuaj yog ib cov tshuaj uas txo cov ntshav qab zib thiab feem ntau yog siv los kho cov ntshav qab zib kom tsawg hauv cov ntshav qab zib.

Ib qho ntawm cov tshuaj tuaj yeem tau txais ntawm cov tshuaj no yog nws txoj kev tswj hwm nyob rau hauv kev tsis muaj txiaj ntsig ntawm cov ntsiav tshuaj siv yav dhau los los ntawm sulfonylurea pawg. Ib qho ntxiv, kev rog dhau yog qhov teeb meem uas tsim teeb meem rau txhua tus neeg mob ntshav qab zib.

Yog vim li ntawd, Langerin tso cai tsis tsuas yog ua kom cov suab thaj qis dua, tab sis kuj tseem ua rau lub cev qeeb dua li qub ntawm tus neeg mob lub cev.

Tshuaj thaj tsob thiab cov cim rau kev siv

Lub tshuab nruab nrab ntawm kev ua ntawm qhov tseem ceeb ntawm cov tshuaj cuam tshuam nrog nws lub peev xwm los txwv cov txheej txheem ntawm gluconeogenesis, nrog rau cov txheej txheem ntawm kev ua ke ntawm cov roj ntsha dawb thiab ua kom muaj roj oxidation.

Tus neeg sawv cev ntawm chav kawm biguanide tsis cuam tshuam rau qhov tshuaj insulin tso rau hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov insulin kom dawb thiab nce qhov feem ntawm insulin rau proinsulin.

Lub ntsiab lus tseem ceeb hauv cov txheej txheem ntawm kev nqis tes ntawm cov ntsiav tshuaj xws li yog qhov kev ua kom pom ntawm qabzib cov nqaij mob hlwb

Qhov tseem ceeb tshaj plaws rau kev siv tshuaj yog kev txhim kho ntawm cov tshuaj insulin-ntshav qab zib hauv ib tus neeg, tshwj xeeb tshaj yog nrog kev tsis muaj txiaj ntsig ntawm kev noj zaub mov ua raws.

Cov khoom tseem ceeb ntawm Langerin muaj xws li:

• txo cov ntshav glycated hemoglobinꓼ
• nruab nrab cov tshuaj insulin tsis ua haujlwm ntawm cov qe rau cov tshuaj hormones insulin
• favorably cuam tshuam qhov normalization ntawm lipid profile ntawm ntshav ntshav ꓼ
• txo cov roj (cholesterol) phem

Tsis tas li ntawd, kev siv cov tshuaj muaj peev xwm ua kom lub cev qhov hnyav.

Cov lus qhia rau kev siv ntsiav tshuaj

Cov tshuaj Langerin yog muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated.

Cov ntawv ntim rau hauv lub hnab yas, uas tau ntim nrog txhuas ntawv ci.

Cov ntim khoom tau muab tso rau hauv lub thawv ntawv thawv nrog cov lus qhia rau kev siv tshuaj.

Ua raws li qhov xav tau ntawm cov tshuaj tau siv, cov tshuaj tuaj yeem tuaj yeem yuav nrog ntau npaum li cas:

1. 500 milligrams.
2. 850 milligrams.
3. Ib qho ntawm cov tshuaj muaj zog.

Cov qauv ntawm kev noj cov ntsiav tshuaj yog qhov ncauj, ntawm lub sijhawm noj mov lossis tom qab nws. Tus kws kho mob uas tuaj koom yuav sau ib qho tshuaj rau txhua tus neeg mob nyob ntawm seb tus kab mob loj npaum li cas. Tsis tas li, tus kws kho mob tshwj xeeb txiav txim siab noj tshuaj ntau npaum li cas thaum nruab hnub.

Langerin-cov lus qhia rau kev siv pom zoo kom pib lub hom phiaj kho mob ntawm kev kho mob nrog kev noj tshuaj tsawg kawg 500 mg ntawm kev siv tshuaj nquag. Tus naj npawb ntawm cov koob tshuaj ntawm lub tshuaj nruab hnub yuav ua tau li ntawm ib mus txog peb.

Maj mam, ntau npaum li cas ntxiv tau nce rau 850 mg ntawm cov tshuaj nquag thoob plaws ib hnub (ib zaug ob zaug hauv ib hnub).

Cov kws kho mob koom nrog saib xyuas qhov mob ntawm tus neeg mob thiab, tsis pub ntau tshaj ib zaug ib lim tiam, kho cov tshuaj ntawm cov tshuaj noj tau nce siab.

Cov tshuaj no tseem tau sau tseg txog kev kho mob rau tus menyuam hauv ntau tshaj kaum xyoo. Kev kho mob Monotherapy yuav tsum pib nrog kev noj tshuaj ntawm 500 mg ntawm cov tshuaj nquag ib zaug lossis ob zaug ib hnub. Tom qab qee lub sijhawm, maj mam nce ntxiv ntawm cov koob tshuaj tau tso cai, tab sis tsis pub ntau tshaj ob grams hauv ib hnub, muab faib ua ob lossis peb koob tshuaj.

Feem ntau, kev hloov pauv hauv cov ntau npaum li cas ntawm cov tshuaj tshwm sim tom qab kaum txog kaum tsib hnub raws li cov txiaj ntsig ntawm kev ntsuas ntshav rau cov piam thaj.

Qee qhov xwm txheej, kev npaj ntsiav tshuaj yog ib feem ntawm kev sib txuas ua ke nrog kev siv tshuaj insulin.

Nws yuav tsum raug sau tseg tias kev tswj hwm ib txhij ntawm Langerin nrog insulin, sulfonylurea derivatives, acarbose, lossis ACE inhibitors yog pom kom nce cov nyhuv hypoglycemic ntawm cov tshuaj.

Qee qhov xwm txheej, tus kws kho mob mus koom yuav hloov qhov kev siv Langerin nrog cov ntsiav tshuaj ntawm cov sib xws. Niaj hnub no, muaj tshuaj ntau ntau, lub ntsiab tseem ceeb ua ke ntawm uas yog metformin.

Tus nqi ntawm cov tshuaj analog tuaj yeem sib txawv, nyob ntawm seb lub tuam txhab ntawm cov chaw muag tshuaj.

Dab tsi yog cov contraindications rau siv?

Cov tshuaj noj tsis raug cai lossis tsis ua raws li cov lus pom zoo ntawm tus kws kho mob tuaj yeem ua rau pom kev phiv tshuaj tsis zoo thaum noj cov tshuaj.

Ntxiv rau, muaj qee kis hauv kev siv tshuaj yeeb tshuaj raws li metformin yog txwv tsis pub.

Cov lus qhia rau kev siv tshuaj qhia cov npe ntawm contraindications tseem ceeb.

Lub ntsiab contraindications rau kev siv ntawm Langerin ntsiav tshuaj suav nrog cov hauv qab no:

• kev ua rau mob siab lossis lub raum tsis ua haujlwm, lawv qhov tsis muaj txiaj ntsig ꓼ
• cawv, suav nrog nyob rau hauv mob ntev formꓼ
• mob plawv los yog kev ua pa tsis ua hauj lwm
• mob myocardial infarctionꓼ
• kev mob nkeeg uas tsis yog mob ntshav qab zib coma lossis poj koob yawm txwvꓼ
• kev loj hlob ntawm tus mob ko taw mob ko taw syndromeꓼ
• nyob rau hauv ib puag ncig ntawm ib tug neeg intolerance rau metformin thiab kev loj hlob ntawm kev tsis haum rau lub componentꓼ
• muaj cov kis mob sib kis-
• yoo mov nrog cov ntshav qab zib lossis ua raws li kev noj haus uas nws noj txhua hnub tsis pub dhau ib txhiab kilocaloriesꓼ
• ua ntej thiab tom qab phaisꓼ
• nrog cov kev raug mob uas tsis ntev los noꓼ
• ua ntej thiab tom qab kev kuaj mob uas siv lub xov tooj cua isotropes ntawm iodineꓼ
• ketoacidosis thiab mob lactic acidosis.

Ntxiv rau, cov poj niam yuav tsum tsis txhob noj cov tshuaj thaum cev xeeb tub thiab lactation.

Qhov tshwm sim ntawm kev mob tshwm sim tuaj yeem tshwm sim nyob rau ib feem ntawm ntau yam plab hnyuv siab raum thiab cov kab ke ntawm tib neeg lub cev - lub plab zom mov, metabolism, kab mob plawv, tawv nqaij ua haujlwm. Cov kev tshwm sim tsis zoo uas tshwm sim los ntawm kev noj tshuaj yog:

1. Txhawb siab flatulence. Qee zaum xeev siab tshwm sim hauv ntshav qab zib hom 2. Xeev siab yuav hloov los ntuav.
2. Kev mob plab mog.
3. Cov tsos ntawm cov xim hlau sib xyaw hauv qhov ncauj kab noj hniav.
4. Hematopoiesis thiab hemostasis.
5. Megaloblastic anemia.
6. Txo cov ntshav qab zib kom qis dua cov qib uas siv tau - hypoglycemia.
7. Cov tsos ntawm tsis muaj zog hauv lub cev.
8. Kev nkees nkees.
9. Kev Ntshav.
10. Kev ua pa ntawm lub siab.
11. Cov tsos ntawm dermatitis lossis ua pob rau ntawm daim tawv nqaij.

Ceev faj yuav tsum tau noj thaum noj Langerin nrog lwm cov tshuaj. Kev siv ua ke nrog cov ntsiav tshuaj nrog cymeditine nce kev pheej hmoo ntawm cov kab mob lactic acidosis. Kev sib xyaw ntawm Langerin nrog lub voj diuretics tuaj yeem txhim kho tib lub txiaj ntsig. Hauv qhov no, ntxiv rau qhov ua rau muaj kev tawm tsam ntawm cov kab mob lactic acidosis, ib qho kev pom ntawm lub raum tsis ua haujlwm tuaj yeem pom.

Siv cov tshuaj, nws yog ib qho tsim nyog los saib xyuas kev ua haujlwm ntawm lub raum thiab txiav txim siab cov lactate hauv ntshav tsawg kawg ob zaug hauv ib xyoos.

Cov lus qhia txog cov tshuaj siv los kho ntshav qab zib tau muab tso rau hauv cov yeeb yaj kiab hauv tsab xov xwm no.

Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo Nrhiav. Nrhiav tsis pom. Tshawb pom. Nrhiav tsis pom. Pom. Nrhiav tsis pom.

Langerin - qhia txog cov tshuaj, cov lus qhia siv, tshuaj xyuas - Lub portal kho mob

Sau ntawv rov los saib dua
1 tshuaj xyuas

Chaw tsim tshuaj paus: Zentiva a.s (Cov koom pheej Slovak)

Yam tshuaj muaj yees

Chav kawm ntawm cov kab mob

• Tsis-insulin-mob ntshav qab zib mellitus

Cov chaw soj ntsuam thiab chaw muag tshuaj

• Tsis teev. Saib cov lus qhia

Pharmacological kev txiav txim

Pharmacological pawg

• Hypoglycemic hluavtaws thiab lwm tus neeg sawv cev hauv kev sib txuas

Qhov ncauj ntawm tes Langerin (Lanagerin)

Cov lus qhia rau kev siv tshuaj

Kev ntsuas rau siv

Hom 2 mob ntshav qab zib mellitus (tshwj xeeb tshaj yog nyob rau hauv cov neeg mob nrog rog) nrog qhov tsis muaj txiaj ntsig ntawm kev txhim kho ntawm hyperglycemia nrog kev noj zaub mov noj, suav nrog nyob rau hauv ua ke nrog sulfonylurea npaj.

Daim ntawv tso tawm

500 mg zaj duab xis-ntsiav tshuaj, blister ntim 10 pob ntawm cardboard 6 pob, 500 ntsiav tshuaj zaj duab xis-ntsiav tshuaj, blister ntim 10 ntim 10 ntim ntawm cardboard 3, 500 mg zaj duab xis-ntsiav tshuaj, blister ntim 10 pob ntawm cardboard 9, tshuaj, 850 mg zaj duab xis-txheej, hlwv ntim 10 pob ntawm cardboard 6, ntsiav tshuaj, 850 mg zaj duab xis-blister ntim, 850 mg zaj duab xis blister pob, 10 ntim ntawm cardboard pob 3, zaj duab xis-coated ntsiav tshuaj 850 mg, blister pob 10 ntim ntawm cardboard 9, ntsiav tshuaj coated nrog zaj duab xis txheej 1 g, sawv hlwv pob 10 ntim ntawm cardboard 1, ntsiav tshuaj coated nrog zaj duab xis plhaub 1 g, sawv hlwv ntim 10 ntim ntawm cardboard 3, ntsiav tshuaj coated nrog zaj duab xis plhaub 1 g, sawv hlwv pob 10 pob ntawv cardboard 9,

ntsiav tshuaj coated nrog zaj duab xis txheej ntawm 1 g, sawv hlwv ntim 10 ntim ntawm cardboard 6,

Siv thaum cev xeeb tub

Thaum cev xeeb tub, nws muaj peev xwm yog tias qhov xav tau ntawm kev kho mob ntau dhau qhov kev pheej hmoo rau tus me nyuam hauv plab (kev tshawb fawb txaus thiab nruj me ntsis ntawm kev siv thaum cev xeeb tub tsis tau ua).

FDA qeb ntawm kev nqis tes ua rau tus menyuam yog B.

Thaum lub sijhawm kho yuav tsum tsis pub niam mis rau menyuam noj.

Kev sib cuam tshuam nrog lwm yam tshuaj

Cov nyhuv ntawm metformin yog qaug zog los ntawm thiazide thiab lwm cov diuretics, corticosteroids, phenothiazines, glucagon, cov thyroid hormones, estrogens, suav nrog ua ib feem ntawm kev tiv thaiv kab mob hauv qhov ncauj, phenytoin, nicotinic acid, sympathomimetics, calcium antagonists, isoniazid.

Hauv tib lub koob tshuaj hauv cov neeg tuaj yeem noj qab haus huv, nifedipine nce kev nqus, Cmax (20%), AUC (9%) metformin, Tmax thiab T1 / 2 tsis hloov.

Cov nyhuv rau hypoglycemic yog muaj zog los ntawm insulin, sulfonylurea derivatives, acarbose, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

Kev tshawb nrhiav ntawm kev noj tshuaj ib zaug hauv cov neeg tuaj yeem noj qab haus huv pom tau tias furosemide nce Cmax (los ntawm 22%) thiab AUC (los ntawm 15%) ntawm metformin (tsis muaj qhov hloov pauv tseem ceeb ntawm kev tshem tawm ntawm metformin), metformin txo Cmax (los ntawm 31%), AUC (los ntawm 12 %) thiab T1 / 2 (32%) ntawm furosemide (tsis muaj qhov hloov pauv tseem ceeb ntawm kev kho lub plab ntawm furosemide). Tsis muaj cov ntaub ntawv hais txog kev cuam tshuam ntawm metformin thiab furosemide nrog kev siv ntev. Tshuaj (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin) zais cia rau hauv cov tubules sib tw rau tubular thauj cov tshuab thiab tuaj yeem nce Cmax ntawm metformin los ntawm 60% nrog kev kho mob ntev. Cimetidine qeeb qeeb ntawm kev txiav tawm cov metformin, uas ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob lactic acidosis. Tsis sib xyaw nrog cawv (muaj kev pheej hmoo ntawm kev tsim cov kua mis acidosis).

Cov kev ceev faj rau kev siv

Cov haujlwm ua haujlwm raum, glomerular pom, thiab ntshav qab zib yuav tsum tau soj ntsuam tas li. Tshwj xeeb tshaj yog ua tib zoo saib xyuas cov ntshav qabzib hauv cov ntshav yog qhov tsim nyog thaum siv metformin ua ke nrog sulfonylureas lossis insulin (muaj kev pheej hmoo ntawm cov ntshav qab zib).

Ua ke nrog kev kho mob nrog metformin thiab insulin yuav tsum tau nqa tawm hauv tsev kho mob kom txog thaum tsim nyog ib koob tshuaj ntawm txhua cov tshuaj tsim.Hauv cov neeg mob ntawm kev kho mob tas mus li nrog metformin, nws yog qhov yuav tsum tau txiav txim siab cov ntsiab lus ntawm cov vitamin B12 ib xyoos ib zaug vim muaj qhov txo qis hauv nws qhov nqus tau.

Nws yog qhov tsim nyog los txiav txim siab txog qib ntawm lactate hauv ntshav tsawg kawg 2 zaug hauv ib xyoos, nrog rau cov tsos ntawm myalgia. Nrog rau qhov nce ntxiv ntawm cov ntsiab lus lactate, cov tshuaj raug muab tso tseg.

Tsis txhob siv ua ntej kev phais thiab tsis pub dhau 2 hnub tom qab lawv tau ua tiav, nrog rau 2 hnub ua ntej thiab tom qab kuaj mob (tshuaj mob ntawm urography, angiography, thiab lwm yam).

Raws li ATX kev faib tawm:

Lub plab zom mov thiab cov metabolism

A10 Tshuaj rau ntshav qab zib

A10B Qhov ncauj tshuaj hypoglycemic

Zoo ib yam tshuaj:

** Qhia Txog Kev Siv Tshuaj Kho Mob yog rau cov lus qhia xwb. Xav paub ntau ntxiv, thov hu rau cov khw muag khoom ntim muag.

Tsis txhob noj tshuaj rau tus kheej, ua ntej koj pib siv Langerin, koj yuav tsum sab laj nrog kws kho mob. EUROLAB tsis yog lub luag haujlwm rau lub txim vim tshwm sim los ntawm kev siv cov ntaub ntawv tshaj tawm ntawm lub portal.

Txhua yam ntaub ntawv ntawm lub vev xaib tsis hloov cov kws kho mob cov lus qhia thiab tsis tuaj yeem ua lub luag haujlwm ntawm lub luag haujlwm zoo ntawm cov tshuaj.

Koj puas nyiam ua Langerin? Koj puas xav paub cov ncauj lus ntxaws ntxaws lossis koj puas xav ntsib kws kho mob? Los yog koj puas xav tau kev kuaj xyuas? Koj ua tau teem sijhawm nrog tus kws kho mob - chaw kho mob Eurolab ib txwm nyob ntawm koj qhov kev pabcuam! Cov kws kho mob zoo tshaj plaws yuav tshuaj xyuas koj, tawm tswv yim, muab kev pabcuam tsim nyog thiab ua kev kuaj mob. Koj tuaj yeem ua tau hu kws kho mob tom tsevCov. Cov chaw kho mob Eurolab qhib rau koj ib ncig ntawm lub moos.

** Mloog! Cov lus qhia hauv phau ntawv qhia tshuaj no yog npaj rau cov kws kho mob thiab tsis yog lub hauv paus rau kev siv tus kheej. Cov lus piav qhia txog cov tshuaj Langerin tau muab rau cov ncauj lus thiab tsis yog tsim los sau kev kho mob yam tsis muaj kev koom tes los ntawm kws kho mob. Cov neeg mob xav tau tswv yim tshwj xeeb!

Yam khoom muaj sia

- Tshuaj metformin hydrochloride (metformin)

Cev xeeb tub thiab lactation

Kev kawm paub txaus thiab tswj hwm kev nyab xeeb ntawm cov metformin thaum cev xeeb tub tsis tau ua. Siv thaum cev xeeb tub yog tsim nyog thaum muaj xwm txheej ceev, thaum xav pom cov txiaj ntsig ntawm txoj kev kho rau leej niam tshaj qhov ua rau muaj qhov muaj mob nyob hauv plab. Metformin hla hla qhov chaw nres nyom.

Cov tshuaj Metformin hauv ib pliag me yog tawm hauv niam cov kua mis, thaum lub siab ntawm cov metformin hauv niam mis tuaj yeem yog 1/3 ntawm cov ntsiab lus hauv leej niam cov ntshav. Tsis pom cov kev mob tshwm sim hauv cov menyuam mos thaum lub sijhawm pub niam mis thaum tseem noj cov tshuaj metformin tsis tau pom.

Txawm li cas los xij, vim tias muaj qee yam ntawm cov ntaub ntawv, kev siv thaum lub sijhawm pub niam mis tsis pom zoo.

Qhov kev txiav txim siab txog kev pub niam mis rau menyuam noj yuav tsum yog txiav txim siab tau txais txiaj ntsig zoo ntawm kev pub niam mis thiab muaj feem ua rau muaj kev phom sij nyob hauv menyuam.

Cov kev tshawb fawb pom tau hais tias metformin tsis muaj teebmeem teratogenic hauv koob tshuaj uas muaj 2-3 zaug siab dua li cov tshuaj kho tau siv hauv tib neeg. Metformin tsis muaj qhov tshwm sim mutagenic, tsis muaj kev cuam tshuam rau kev muaj menyuam.