Maninil (Glibenclamide)

Ntshav qab zib mellitus yog ib qho mob hnyav tshaj plaws ntawm tus txiv neej niaj hnub. Yog tias tsis muaj cov tshuaj tshwj xeeb, cov neeg uas muaj cov teeb meem no tsis tuaj yeem muaj sia nyob. Thiab yog lawm, txoj kev kho rau cov ntshav qab zib yuav tsum tau xaiv kom raug. Ntau zaus, cov kws kho mob tau sau ntawv yuav siv cov tshuaj "Maninil" zoo rau cov neeg mob. Cov lus qhia rau kev siv, nqe, tshuaj xyuas, tshuaj piv txwv ntawm cov tshuaj no - peb yuav tham txog txhua yam no tom qab hauv tsab xov xwm.

Cov tshuaj no tau muab rau hauv cov qauv ntawm cov ntsiav tshuaj. Nws lub ntsiab ua haujlwm tseem ceeb yog g libenclamide. Ib ntsiav tshuaj ntawm cov tshuaj no yuav muaj 3.5 lossis 5 mg. Tsis tas li, cov tshuaj muaj pes tsawg leeg suav nrog lactose, qos hmoov txhuv nplej siab, silicon dioxide thiab qee yam khoom sib xyaw. Lub tuam txhab Berlin Chemi koom nrog kev tso tawm cov tshuaj no.

Cov tshuaj "Maninil" nws kim heev. Nws tus nqi yog kwv yees li 150-170 p. rau 120 ntsiav tshuaj.

Nyob rau hauv dab tsi mob yog contraindications tshuaj

Ib zaug nyob hauv tus neeg mob lub cev, cov tshuaj "Maninil" (nws cov analogues yuav txawv txav) nce rhiab heev ntawm cov insulin receptors. Nws muaj cov tshuaj nquag ntawm cov tshuaj no thiab lwm cov txiaj ntsig zoo rau tus neeg mob lub cev. Maninil, thiab lwm yam, tuaj yeem txhawb lub zog tsim cov tshuaj insulin.

Kev qhia rau kev siv cov tshuaj no yog ntshav qab zib hom 2. Cov tshuaj no tsuas yog kho los ntawm tus kws kho mob endocrinologist. Contraindications rau nws siv yog:

ntshav qab zib hom 1

mob ntshav qab zib coma thiab precoma,

cev xeeb tub thiab lactation,

mob raum lossis lub siab ua haujlwm poob,

txo cov qe ntshav dawb.

Yuav siv li cas

Rau cov ntsiav tshuaj 5 mg yog raws nraim tib yam li rau cov tshuaj "Manin 3.5", cov lus qhia rau kev siv. Tus nqi (cov qauv tshuaj yuav muaj nqi sib txawv) rau cov tshuaj no, raws li twb tau hais, kuj muaj ntau. Ib qho ntxiv, cov kws kho mob tau muab nws rau cov neeg mob pub dawb, tsis zoo li hloov pauv pheej yig, tsis tshua muaj nqi. Tias yog vim li cas ntau tus neeg mob xav paub seb cov tshuaj no puas muaj cov tshuaj analogues pheej yig dua. Cov tshuaj no muaj nyob hauv cov tsev muag tshuaj. Tab sis ua ntej taug mus rau lawv cov lus piav qhia, peb yuav pom cov lus qhia dab tsi rau kev siv cov khoom Manilin nws tus kheej txawm li cas los muaj.

Tus kws kho mob xaiv cov koob tshuaj no rau tus neeg mob ib tus zuj zus. Qhov ntau npaum li cas ntawm cov tshuaj noj ib hnub nyob ntawm tsuas yog nyob rau theem ntawm cov piam thaj hauv cov zis. Lawv pib haus cov tshuaj no feem ntau nrog kev noj tsawg kawg. Ntxiv mus, tom kawg tau nce. Feem ntau, thaum thawj theem, tus neeg mob tau sau cia ib nrab ib ntsiav tshuaj hauv ib hnub (nyob ntawm kev soj ntsuam, 3.5 lossis 5 mg). Tom ntej no, cov koob tshuaj tau nce siab tsis pub ntau tshaj ib ntsiav tshuaj ib lis piam lossis ob peb hnub.

Kev txheeb xyuas txog "Maninil"

Nov yog cov lus qhia rau kev siv rau cov tshuaj “Maninil”. Analogues ntawm cov tshuaj no muaj ntau heev. Tab sis "Maninil" ntau tus neeg mob xav txog qhov zoo tshaj plaws khoom siv hauv lawv pab pawg. Lub tswv yim ntawm cov neeg mob ntshav qab zib mellitus txog cov tshuaj no tau tsim kho zoo heev. Nws pab, raws li cov neeg siv khoom feem ntau, tsuas yog zoo. Txawm li cas los xij, hmoov tsis zoo, cov tshuaj no tsis haum rau txhua tus neeg mob. Nws tsuas yog tsis mus rau qee cov neeg mob.

Txawm li cas los xij, tsis muaj kev zam, cov neeg mob pom zoo kom haus cov tshuaj no tshwj xeeb ntawm kev noj tshuaj uas tus kws kho mob pom zoo. Txwv tsis pub, cov tshuaj yuav ua rau qaug cawv.

Cov analogues ntawm cov tshuaj "Manin"

Muaj ntau yam hloov rau cov tshuaj no hauv cov kev lag luam niaj hnub no. Qee qhov ntawm lawv tau khwv tau zoo rau cov neeg siv khoom tshuaj, thaum lwm tus tsis muaj.

Feem ntau, cov neeg mob ntshav qab zib siv cov npe sib piv nrog cov npe hauv qab no hloov "Maninil":

Qee lub sij hawm cov neeg mob tau mob siab xav seb puas muaj tshuaj analog ntawm Manil 3.5 mg (ntsiav tshuaj) ntawm kev ua lag luam. Nws tsis muaj qhov lus txhais rau cov tshuaj no hauv lub khw muag tshuaj niaj hnub no. Feem ntau cov analogues yog tsim nyob rau hauv lub hauv paus ntawm lwm yam tshuaj nquag. Thiab vim li no, cov qib loj ntawm cov muaj pes tsawg leeg hauv cov ntsiav tshuaj hloov pauv txawv. Tsuas yog cov qauv txheej txheem ntawm Maninil yog Glibenclamide. Tsuas yog qhov hloov pauv no tuaj yeem muas hauv kev muab tshuaj ntawm 3.5 mg.

Cov tshuaj "Glibenclamide"

Kev ntsuas thiab contraindications rau cov tshuaj no yog tib yam li rau "Maninil" nws tus kheej. Tom qab tag nrho, qhov tseeb, cov tshuaj no yog nws cov khoom pheej yig. Cov tshuaj no muaj nqis hauv cov chaw muag tshuaj kwv yees li 80-90 p. Txawm hais tias qhov tshuaj yeeb dej caw muaj sib npaug rau ob qho tib si ntawm cov tshuaj no, hloov Maninil nrog Glibenclamide tsuas yog tso cai los ntawm kev pom zoo los ntawm tus kws kho mob. Ntshav qab zib mellitus yog ib qho mob loj heev. Cov tshuaj no yog tsim nyob hauv Ukraine.

Tus Neeg Mob Txoj Kev Xav rau ntawm Glibenclamide

Zoo li Maninil, kev tshuaj xyuas (cov yeeb yaj kiab ntawm cov tshuaj no nrog lwm cov tshuaj rau cov neeg mob feem ntau mus zuj zus), cov tshuaj no los ntawm cov neeg siv khoom tau txais txiaj ntsig zoo. Ntxiv rau qhov kev ua tau zoo, kev nqis tes ntawm qhov zoo ntawm cov tshuaj no, ntau tus neeg mob ntaus nqi nws tus nqi qis thiab yooj yim ntawm kev faib cov ntsiav tshuaj. Ntau tus neeg mob xav txog Glibenclamide tshuaj tsim hauv Kiev kom tau zoo dua. Kharkov ntsiav tshuaj thaum faib, hmoov tsis, tuaj yeem tsoo.

Cov tshuaj "Diabeton"

Cov tshuaj no muaj nyob hauv daim ntawv dawb oval ntsiav tshuaj. Nws lub ntsiab khoom xyaw ua ke yog glycoside. Zoo li Maninil, Diabeton belongs rau cov pab pawg ntawm cov piam thaj txo cov tshuaj ntawm lub xeem tiam. Qhov tseem ceeb tseem ceeb ntawm cov tshuaj no yog, ntxiv rau kev ua haujlwm, tsis muaj yees. Tsis zoo li Maninil, Diabeton tso cai rau koj los kho lub ncov thaum ntxov thiab tiv thaiv kev txhim kho hyperinsulinemia. Qhov zoo ntawm cov cuab yeej no, hauv kev sib piv nrog ntau lwm cov tshuaj ntawm pab pawg no, suav nrog qhov tseeb tias nws muaj peev xwm txo cov ntshav cov roj hauv cov ntshav.

Xyuas rau "Tus kab mob ntshav qab zib"

Cov piam thaj hauv cov ntshav, raws li cov neeg mob feem ntau, cov tshuaj no kuj tseem txo qis zoo heev. Cov kev mob tshwm sim, raws li cov neeg tau txais kev pab, "Diabeton" muab tsis tshua muaj heev. Yuav luag txhua tus neeg mob suav tias qhov tshuaj tsis zoo ntawm cov tshuaj no feem ntau ua rau nws tus nqi kim. Koj yuav tsum them nws ntau dua rau Maninil. Analogs (tus nqi ntawm cov tshuaj siv rau ntshav qab zib tuaj yeem sib txawv heev) ntawm cov tshuaj no feem ntau pheej yig dua. Tus mob ntshav qab zib yog qhov kev zam ntawm qhov teeb meem no. Muaj ib pob ntawm 60 ntsiav tshuaj ntawm cov khoom no hauv cov chaw muag tshuaj ntawm cov lus txib ntawm 300 r. Cov tshuaj no tsim nyog, zoo li feem ntau cov tshuaj txo suab thaj, hmoov tsis zoo, tsis yog rau txhua tus neeg mob.

Cov tshuaj "Metformin"

Cov tshuaj no tseem muaj nyob hauv cov ntsiav tshuaj thiab chaw muag tshuaj thiab cov chaw kho mob. Nws lub ntsiab nquag khoom siv yog metformin hydrochloride. Cov nyhuv pharmacological ntawm tus neeg sawv cev no yog pom qhov tseem ceeb hauv qhov tseeb tias nws txo tus nqi ntawm kev nqus ntawm cov piam thaj los ntawm cov hnyuv. Nws tsis thim ib qho kev cuam tshuam rau cov txheej txheem ntawm cov tshuaj insulin ntau lawm, xws li Glibenclamide thiab Maninil. Ib qho ntawm qhov tsis paub meej ntawm cov tshuaj no yog tias nws tsis ua rau qhov tshwm sim ntawm cov tsos mob ntawm lub qog ntshav hauv lub cev.

Kev Tshawb Xyuas Txog Metformin

Cov neeg mob qhuas txog cov tshuaj no feem ntau rau nws kev ua txhaum me. Metformin tau khwv tau tshuaj xyuas zoo thiab rau qhov tseeb tias nrog nws siv nws muaj peev xwm ua tsis tau tsuas yog los kho kab mob ntshav qab zib nkaus xwb. Txhawb nqa kev siv cov tshuaj no thiab cov neeg poob phaus. Zoo li Cov Ntshav Qab Zib, cov tshuaj no, ntawm lwm yam, ua kom cov cholesterol nyob hauv cov ntshav ntawm cov neeg mob. Ib qho ntxiv ntawm cov khoom no tseem suav hais tias yog tus nqi tsis tshwj xeeb: 60 ntsiav tshuaj ntawm Metformin raug nqi kwv yees li 90 r.

Qee qhov tsis zoo ntawm cov tshuaj no, cov neeg siv khoom siv tsuas yog qhov tseeb tias hauv thawj lub hlis ntawm kev noj nws, nws tuaj yeem ua rau mob plab zom mov. Qee qhov kev mob tshwm sim no qee zaum muab los ntawm Maninil nws tus kheej. Nws cov lus sib piv feem ntau kuj sib txawv nyob rau hauv cov khoom qub. Tab sis cov kev mob tshwm sim nyob rau hauv daim ntawv ntawm zawv plab hauv feem ntau ntawm cov tshuaj no feem ntau tseem tsis tau tawm suab.

Cov tshuaj "Glimepiride" ("Amaril")

Cov tshuaj no tau tsim tawm ntawm cov tshuaj hu ua glimepiride. Nws muaj cov nyom ua rau tus neeg mob lub cev - nws ua rau lub ntsej muag, tiv thaiv kev tsim cov piam thaj hauv lub siab, thiab ua rau cov nqaij hauv lub cev ntau ntxiv rau qhov kev ua ntawm lub cev. Cov tshuaj no zoo heev txo cov kev pheej hmoo ntawm kev mob ntshav qab zib mob hlwb. Feem ntau, Amaril yog tshuaj los ntawm cov kws kho mob tib lub sijhawm uas yog Metformin. Ntawm kev muag niaj hnub no tseem muaj tshuaj, uas yog ib qho kev ua si ntawm cov tshuaj yeeb dej caw ntawm ob qho ntawm cov nyiaj no. Nws hu ua Amaril M.

Tshuaj Ntsuam Xyuas

Lub tswv yim hais txog cov tshuaj no hauv cov neeg muaj ntshav qab zib tsuas yog qhov zoo heev. Cov txiaj ntsig ntawm nws txoj kev siv yog feem ntau pom tau. Nws ntseeg tau tias kev siv cov tshuaj no yog qhov zoo dua yog tias Metformin ib leeg tsis pab. Qhov ntau thiab tsawg ntawm Amarin ntsiav tshuaj yog loj. Ntxiv rau, lawv muaj kev pheej hmoo. Yog li ntawv, sib qhia yog tsim nyog nws yooj yim heev.

Cov tshuaj "Glucophage"

Cov tshuaj no yog qhov ua kom zoo nrog Metformin. Cov tshuaj nquag yuav zoo ib yam rau nws. Tib yam mus rau qhov ntsuas thiab contraindications. Zoo li Metformin, qhov kev kho mob no ua rau pom tus neeg mob lub cev. Nws kuj txo qhov hnyav tsis txaus.

Hloov ib txoj kev xaus

Yog li, peb pom tias "Maninil" yog dab tsi (cov lus qhia rau kev siv, tus nqi, analogues tam sim no tau paub rau koj). Qhov kev hais daws no, zoo li koj pom, yeej pab tau. Feem ntau ntawm nws cov counterparts kuj tsim nyog tsuas yog kev tshuaj xyuas zoo los ntawm cov neeg mob. Txawm li cas los xij, nws yog ib qho tsim nyog siv cov tshuaj no thiab hloov nws nrog lwm cov tshuaj nrog cov nyhuv kho zoo sib xws, tau kawg, tsuas yog kev pom zoo los ntawm tus kws kho mob.

Pharmacological kev txiav txim

Kev siv tshuaj yaj yeeb hypoglycemic los ntawm pawg sulfonylurea derivatives ntawm lub cim thib ob.

Nws stimulates insulin secretion los ntawm khi rau pancreatic cell-cell membrane tshwj xeeb receptors, txo qhov pib rau pancreatic cell-cell kua nplaum voos, nce insulin rhiab heev thiab nws khi rau lub hom phiaj hlwb, nce insulin tso tawm, ua rau muaj kev cuam tshuam ntawm insulin ntawm cov leeg qabzib nce siab thiab mob siab, yog li txo qhov kev txiav txim siab ntawm cov piam thaj hauv cov ntshav. Kev ua nyob rau theem ob ntawm insulin secretion. Nws inhibits lipolysis nyob rau hauv cov ntaub so ntswg adipose. Nws muaj lipid-txo cov nyhuv, txo qhov ua kom lub zog thrombogenic ntawm cov ntshav.

Maninil® 1.5 thiab Maninil® 3.5 nyob rau hauv micronized daim ntawv yog lub siab, tshwj xeeb tshaj yog hauv av daim ntawv ntawm glibenclamide, uas tso cai rau cov tshuaj nqus tawm ntawm lub plab nyhuv sai dua. Hauv kev sib txuas nrog kev ua tiav dhau los ntawm Cmax ntawm glibenclamide hauv ntshav, cov nyhuv hypoglycemic yuav luag raug rau lub sijhawm nce ntxiv hauv kev mloog zoo ntawm cov piam thaj hauv cov ntshav tom qab noj mov, uas ua rau cov nyhuv ntawm cov tshuaj softer thiab physiological. Lub sijhawm ntawm hypoglycemic kev ua yog 20-24 teev.

Qhov ua rau lub ntsej muag hypoglycemic ntawm cov tshuaj Maninil® 5 kev txhim kho tom qab 2 teev thiab kav ntev li 12 teev.

Cov Tshuaj Pharmacokinetics

Tom qab noj cov tshuaj Maninil 1.75 thiab Maninil 3.5, kev nqus sai thiab yuav luag tiav los ntawm kev kho mob txoj hnyuv. Tso tawm tag nrho ntawm cov tshuaj microionized nquag tshwm sim hauv 5 feeb.

Tom qab kev noj cov tshuaj ntawm Maninil 5, nqus ntawm lub plab zom mov yog 48-84%. Tmax - 1-2 teev. Teev tsis raug bioavailability - 49-59%.

Plasma protein khi yog ntau tshaj li 98% rau Maninil 1.75 thiab Maninil 3.5, 95% rau Maninil 5.

Kev ntsuas phoo thiab nthuav tawm

Yuav luag txhua qhov ua tiav nyob hauv daim siab nrog rau kev tsim ntawm ob lub cev tsis ua haujlwm, ib qho yog tawm los ntawm lub raum, thiab lwm qhov yog cov kua tsib.

T1 / 2 rau Maninil 1.75 thiab Maninil 3.5 yog 1.5-3.5 teev, rau Maninil 5 - 3-16 teev.

Kev noj tshuaj ntxiv

Tus kws kho mob teeb tsa qhov muab tshuaj ntawm cov tshuaj ib lub zuj zus raws li kev mloog zoo ntawm cov piam thaj hauv cov ntshav ntawm lub plab thiab 2 teev tom qab noj mov.

Thawj koob tshuaj ntawm cov tshuaj Maninil 1.75 yog 1 / 2-1 ntsiav tshuaj 1 zaug hauv ib hnub. Nrog cov txiaj ntsig tsis txaus nyob hauv kev saib xyuas ntawm tus kws kho mob, qhov tshuaj ntawm cov tshuaj yog maj mam nce kom txog rau hauv qhov kev noj tshuaj txhua hnub tsim nyog txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau mus kawm. Qhov nruab nrab txhua hnub koob tshuaj yog 2 ntsiav tshuaj (3.5 mg). Qhov koob tshuaj ntau tshaj txhua hnub yog 3 ntsiav tshuaj (hauv qhov tshwj xeeb, 4 ntsiav tshuaj).

Yog tias nws yog qhov tsim nyog kom tau txais cov tshuaj ntau dua, lawv hloov mus rau noj cov tshuaj Maninil 3.5.

Thawj koob tshuaj Maninil® 3.5 yog 1 / 2-1 ntsiav tshuaj 1 zaug hauv ib hnub. Nrog cov txiaj ntsig tsis txaus nyob hauv kev saib xyuas ntawm tus kws kho mob, qhov tshuaj ntawm cov tshuaj yog maj mam nce kom txog rau hauv qhov kev noj tshuaj txhua hnub tsim nyog txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau mus kawm. Qhov nruab nrab txhua hnub koob tshuaj yog 3 ntsiav tshuaj (10.5 mg). Qhov siab tshaj plaws niaj hnub noj yog 4 ntsiav tshuaj (14 mg).

Cov tshuaj yuav tsum tau noj ua ntej noj mov, tsis yog txhawm thiab haus ib qho kua tsawg. Kev noj tshuaj txhua hnub txog 2 ntsiav tshuaj yuav tsum noj ib hnub ib zaug - thaum sawv ntxov, ua ntej noj tshais. Cov qib siab dua tau muab faib rau cov koob tshuaj thaum sawv ntxov thiab yav tsaus ntuj. Yog tias koj hla ib qho tshuaj ntawm cov tshuaj, cov ntsiav tshuaj tom ntej yuav tsum noj nyob rau lub sijhawm ib txwm, thaum nws tsis pub noj ntau dua.

Thawj koob tshuaj Maninil® 5 yog 2.5 mg 1 zaug ib hnub. Nrog cov txiaj ntsig tsis txaus, nyob rau hauv kev saib xyuas ntawm tus kws kho mob, qhov tshuaj ntawm cov tshuaj tau maj mam nce los ntawm 2.5 mg rau ib hnub nrog qhov luv ntawm 3-5 hnub kom txog rau thaum cov koob tshuaj txhua hnub tsim nyog txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau mus txog. Qhov koob tshuaj rau txhua hnub yog 2.5-15 mg.

Cov koob tshuaj ntau dua 15 mg rau ib hnub tsis nce qhov hnyav ntawm cov nyhuv hypoglycemic ntawm cov tshuaj.

Hauv cov neeg mob laus, muaj kev pheej hmoo ntawm kev mob hypoglycemia, yog li ntawd, rau lawv, cov koob tshuaj yuav tsum pib 1 mg ib hnub twg, thiab koob tshuaj txij nkawm yuav tsum raug xaiv los ntawm kev saib xyuas ntawm tus kws kho mob.

Zaus ntawm kev noj tshuaj Maninil® 5 yog 1-3 zaug hauv ib hnub. Cov tshuaj yuav tsum tau noj 20-30 feeb ua ntej noj mov.

Thaum hloov los ntawm lwm cov kab mob hypoglycemic nrog lub ntsej muag zoo sib xws ntawm kev sib raug zoo, Maninil® 5 yog tshuaj raws li cov txheej txheem saum toj no, thiab cov tshuaj ua dhau los raug muab tso tseg. Thaum hloov los ntawm biguanides, qhov pib siv tshuaj rau txhua hnub yog 2.5 mg, yog tias tsim nyog, qhov koob tshuaj txhua hnub tau nce txhua txhua 5-6 hnub los ntawm 2.5 mg kom txog thaum them nyiaj tiav. Thaum tsis muaj cov nyiaj them poob haujlwm tsis dhau 4-6 lub lis piam, nws yog qhov yuav tsum tau txiav txim siab ntawm kev sib xyaw ua ke nrog kev siv tshuaj insulin.

Sab sij huam

Qhov tshwm sim feem ntau cov kev tsis zoo hauv kev kho mob nrog Maninil® yog hypoglycemia. Tus mob no tuaj yeem coj lub sijhawm ntev thiab pab txhawb rau hauv kev txhim kho ntawm cov mob hnyav (txog li tsis nco qab lossis xaus rau lub cev tuag). Nrog rau cov txheej txheem qeeb, mob ntshav qab zib polyneuropathy, los yog nrog kho tus mob nrog cov neeg muaj mob sympatholytic, cov xwm txheej ua ntej ntawm hypoglycemia tej zaum yuav mob sib khuav xwb los sis tsis tuaj kiag li.

Cov laj thawj ntawm kev ua ntshav siab tuaj yeem yog: kev noj tshuaj ntau dhau, qhia qhov tsis raug, noj mov tsis xwm yeem, cov neeg laus cov neeg mob, ntuav, raws plab, lub cev ntau dhau, cov kab mob uas txo qis qhov xav tau ntawm insulin (kev mob siab rau lub siab thiab lub raum kev ua haujlwm, kev ua haujlwm ntawm adrenal cortex, pituitary lossis thyroid caj pas) , haus dej cawv, nrog rau kev sib cuam tshuam nrog lwm yam tshuaj.

Cov tsos mob ntawm tus mob ntshav qab zib muaj xws li kev tshaib plab heev, tawm hws sai sai, tawm hws sai, hais lus tawv nqaij, nqaij tawv, qhov ncauj ntawm qhov ncauj, tshee tshee, kev ntxhov siab, mob taub hau, mob taub hau, pw tsaug zog, ntxhov siab, ntshai kev cuam tshuam ntawm kev txav mus los, ib ce ntawm cov leeg mob ib ntus (piv txwv, kev cuam tshuam ntawm cov leeg tsis tuaj ib ce). lub zeem muag thiab hais lus, kev tshwm sim hauv paresis lossis tuag tes tuag taw lossis kev hloov pauv ntawm cov kev nkag siab. Nrog rau kev nce qib ntawm hypoglycemia, cov neeg mob yuav plam lawv tus kheej kev tswj hwm thiab kev nco qab. Feem ntau xws li tus neeg mob tau ntub, tawv nqaij noo thiab ib qho kab mob rov huam dua.

Cov kev mob tshwm sim tom qab no kuj tseem siv tau.

Los ntawm cov txheej txheem hauv plab: tsis tshua muaj - xeev siab, ntuav, ntuav, xim hlau hauv lub qhov ncauj, hnov ​​qhov hnyav thiab tag nrho ntawm lub plab, mob plab thiab mob raws plab, qee qhov - ib ntus nce ntxiv hauv kev ua haujlwm ntawm daim siab enzymes (GSH, GPT, ALP), tshuaj tiv thaiv kab mob siab thiab daj.

Kev tsis haum tshuaj: pob khaus, pruritus, urticaria, liab ntawm daim tawv nqaij, Quincke's edema, pom cov ntshav tawm hauv daim tawv, khaus khaus tawm ntawm qhov chaw loj ntawm cov tawv nqaij, nce ntxiv ntawm qhov tawv nqaij. Tsis tshua muaj tshwm sim, cov tawv nqaij ua haujlwm tuaj yeem ua lub hauv paus pib ntawm kev txhim kho ntawm cov mob hnyav, nrog los ntawm kev ua pa luv thiab txo ntshav siab kom txog thaum pib ntawm kev poob siab, uas tsim kev hem thawj rau tus neeg mob lub neej. Qee qhov kev qhia txog kev tsis haum tshuaj nrog rau daim tawv nqaij sawv pob, mob sib koom tes, ua npaws, qhov tsos ntawm cov protein nyob hauv cov zis thiab lub ntsej muag daj tau piav qhia.

Los ntawm cov kab mob hematopoietic: tsis tshua muaj - thrombocytopenia, erythropenia, leukocytopenia, agranulocytosis, nyob rau hauv tus neeg mob cais tawm - hemolytic anemia lossis pancytopenia.

Lwm yam: nyob rau hauv tus neeg mob cais, muaj cov diuretic uas tsis muaj zog, pom tshwm sim ib ntus ntawm cov protein nyob hauv cov zis, tsis pom kev tsis pom kev zoo thiab chaw nyob, nrog rau cov kev mob cuam tshuam los ntawm haus dej cawv tom qab haus cawv, qhia los ntawm cov teeb meem ntawm cov ntshav ncig thiab ua pa ntawm lub plab (ntuav, hnov ​​qhov kub ntawm lub ntsej muag thiab lub cev) , tachycardia, kiv taub hau, mob taub hau).

Txoj kev tiv thaiv tsis zoo rau kev siv tshuaj MANINIL®

• ntshav qab zib hom 1
• ketoacidosis, mob ntshav qab zib precoma thiab coma,
• mob tom qab kuaj cov leeg nqaij tus mob,
• mob ua rau daim siab mob hnyav,
• mob raum mob raum (CC tsawg dua 30 ml / min),
• qee qhov mob hnyav (piv txwv li, decompensation ntawm carbohydrate metabolism hauv cov kab mob sib kis, kub hnyiab, raug mob lossis tom qab phais mob loj thaum siv tshuaj tua kab mob insulin),
• leukopenia
• hnyuv ob leeg, paresis ntawm lub plab,
• mob nrog malabsorption ntawm cov zaub mov thiab cov kev txhim kho ntawm hypoglycemia,
• cev xeeb tub
• lactation (noj niam mis),
• paub txog qhov ua kom mob siab rau glibenclamide thiab / lossis lwm yam sulfonylurea derivatives, sulfonamides, diuretics (diuretics) uas muaj cov sulfonamide pawg hauv cov qauv molecule, thiab rau probenecid, txij li cov kab mob sib kis tuaj yeem tshwm sim.

Nrog kev ceev faj, cov tshuaj yuav tsum tau tsim rau febrile syndrome, cov thyroid kab mob (nrog kev ua haujlwm tsis zoo), hypofunction ntawm anterior pituitary lossis adrenal cortex, cawv, nyob rau hauv cov neeg laus laus vim qhov muaj feem ntawm kev txhim kho hypoglycemia.

Cov lus qhia tshwj xeeb

Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam kom tsis tu ncua cov concentration ntawm cov piam thaj hauv cov ntshav ntawm lub plab khoob thiab tom qab noj mov.

Cov neeg mob yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib siab ntau thaum muaj kev sib xyaw ua ke ntawm kev noj haus (nrog rau kev txhim kho ntawm disulfiram-zoo li tus mob: mob plab, xeev siab, ntuav, mob taub hau) thiab thaum lub sij hawm tshaib plab.

Tus kws kho mob yuav tsum ua tib zoo xav txog kev teem sijhawm rau tshuaj Maninil® rau cov neeg mob uas lub siab thiab lub raum tsis ua haujlwm, nrog rau kev mob hypothyroidism, anterior pituitary lossis adrenal cortex.

Kev txhaj tshuaj rau cov tshuaj Maninil® yog qhov tsim nyog rau kev tawm dag zog lub cev thiab lub siab, hloov kev noj haus.

Thaum kho, nws tsis pom zoo kom nyob hauv lub hnub ntev.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Nyob rau lub sijhawm kom txog rau qhov zoo tshaj plaws tau tsim los lossis thaum hloov tshuaj, nrog rau kev tswj hwm tsis raug cai ntawm cov tshuaj Maninil®, muaj peev xwm tsav tsheb lossis tswj tau ntau yam txheej txheem, nrog rau koom nrog rau lwm yam kev phom sij uas xav tau nce siab thiab ceev ntawm lub hlwb thiab lub cev kev xav, yog tau Cov.

Noj ntau dhau

Cov tsos mob: ib qho mob loj heev ntawm kev siv tshuaj Maninil®, nrog rau kev siv tshuaj ntau hauv cov koob tshuaj siab, tuaj yeem ua rau mob ntshav qab zib tsis txaus, uas tsis tshua muaj mob hem thawj rau tus neeg mob lub neej.

Kev Kho Mob: mob me ntsis ntawm hypoglycemia, uas yog thawj yam ua ntej ntawm nws, tus neeg mob tuaj yeem tshem tawm nws tus kheej los ntawm kev noj tam sim ntawd ib qho qab zib, jam, zib ntab, haus ib khob dej tshuaj yej los yog kua qab zib. Yog li ntawd, tus neeg mob yuav tsum muaj ib txwm nrog nws ua ob peb daim ntawm cov piam thaj ua kom huv los yog muab zais ua khoom qab zib (khoom qab zib). Cov khoom lag luam tsis meej rau cov neeg mob ntshav qab zib tsis pab rau cov xwm txheej zoo li no. Yog tias tus neeg mob tsis tuaj yeem tshem tawm cov tsos mob ntawm tus mob ntshav qab zib tsawg, tam sim ntawd nws yuav tsum hu kws kho mob. Thaum lub cev tsis nco qab, ib qho 40% dextrose daws yog txhaj rau hauv / hauv, i / m 1-2 mg ntawm glucagon. Tom qab nws rov qab nco qab, tus neeg mob yuav tsum tau muab cov zaub mov muaj nplua nuj nyob hauv kev zom cov zaub mov tau yooj yim (kom tsis txhob rov qab txhim kho kev mob ntshav qab zib tsawg).

Yeeb tshuaj sib cuam tshuam

Ib qho kev nce hauv hypoglycemic nyhuv ntawm Maninil should kev npaj yuav tsum tau xav tias nyob rau hauv cov xwm txheej no thaum kho nrog ACE inhibitors, tus neeg sawv cev anabolic, lwm qhov ncauj tshuaj hypoglycemic (piv txwv li, acarbose, biguanides) thiab insulin, azapropasone, beta-blockers, quinine, quinolone, chloram derivatives thiab nws cov lus sib piv, coumarin derivatives, disopyramide, fenfluramine, pheniramidol, fluoxetine, MAO inhibitors, miconazole, PASK, pentoxifylline (hauv koob tshuaj ah parenterally), perhexiline, pyrazolone derivatives, phenylbutazones, phosphamides (e.g. cyclophosphamide, ifosfamide, trophosphamide), probenecid, salicylates, sulfinpyrazone, sulfanilamides, tetracyclines, tritokvalin, nrog rau kev haus dej cawv.

Cov neeg tso zis acidifying agents (ammonium chloride, calcium chloride) txhim kho cov nyhuv ntawm cov tshuaj Maninil® los ntawm kev txo qis hauv nws cov neeg ua haujlwm tsis zoo thiab ua kom nws txoj kev rov cuam tshuam dua.

Nrog rau kev nce ntxiv hauv cov nyhuv hypoglycemic, beta-blockers, clonidine, guanethidine thiab reserpine, nrog rau cov tshuaj nrog lub hauv nruab nrab ntawm kev ua, tuaj yeem ua rau lub zog ntawm qhov ua ntej ntawm hypoglycemia.

Cov nyhuv hypoglycemic ntawm Maninil® yuav txo qis nrog kev siv barbiturates tib lub sijhawm, isoniazid, cyclosporine, diazoxide, GCS, glucagon, nicotinates (hauv qib siab), phenytoin, phenothiazines, rifampicin, saluretics, acetazolamide, cov tshuaj tiv thaiv kev sib deev (e.g. cov tshuaj hormones, hormonal) cov thyroid caj pas, cov kab mob sympathomimetic, indomethacin thiab ntsev ntsev.

Kev siv dej cawv thiab tshuaj yeeb dej cawv ntev dhau los yuav ua rau kev ua txhaum ntawm cov metabolism hauv cov metabolism.

H2 receptor antagonists tuaj yeem ua kom tsis muaj zog, ntawm ib sab tes, thiab txhim kho cov nyhuv hypoglycemic ntawm Maninil® ntawm lwm qhov.

Muaj qee zaus, pentamidine tuaj yeem ua rau muaj zog txo lossis nce ntxiv hauv cov ntshav cov piam thaj.

Nrog rau kev siv thooj txhij nrog cov tshuaj Maninil®, cov txiaj ntsig ntawm coumarin derivatives yuav nce ntxiv los yog tsawg dua.

Cov tshuaj noj uas ua kom cov leeg hlwb hematopoiesis nce siab kev pheej hmoo ntawm myelosuppression thaum siv nrog Maninil®.

Tus neeg mob yuav tsum tau qhia los ntawm tus kws kho mob tias muaj kev cuam tshuam.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj muaj 1.75 mg, 3.5 mg lossis 5 mg ntawm glibenclamide.

Ntu cov khoom sib xyaw ntawm Maninyl 1.75 thiab 3.5 yog lactose monohydrate, cov hmoov txhuv nplej siab, hemetellose, silicon colloidal dioxide, magnesium stearate, ponce zas Ponso 4R, Maninil 5 - lactose monohydrate, pob kws hmoov txhuv nplej siab, magnesium starate, gelatin, talc Ponce zas xim 4R.

Kev ntsuas rau siv

Raws li cov ntaub ntawv tau teev nyob rau hauv cov lus qhia rau Maninil, cov tshuaj no yog npaj rau kev kho mob hom 2 mob ntshav qab zib mellitus, ob qho tib si li monotherapy thiab raws li ib feem ntawm kev sib koom ua ke hauv kev sib xyaw ua ke nrog lwm tus neeg hauv lub qhov ncauj hypoglycemic, tsuas yog zam ntawm clayides thiab sulfonylurea derivatives.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Maninil yog txiav txim los ntawm tus kws kho mob mus kawm nyob ntawm qhov mob hnyav ntawm cov chav kawm, tus neeg mob lub hnub nyoog, yoo cov ntshav qabzib siab thiab ob teev tom qab noj mov.

Thawj qhov tshuaj thawj zaug yog:

• Maninil 1.75 - 1-2 ntsiav tshuaj ib hnub,
• Maninil 3.5 thiab 5 - 1 / 2-1 tab. ib hnub.

Nrog cov txiaj ntsig tsis txaus, qhov ntau npaum li cas yog maj mam nce kom txog thaum cov metabolism hauv carbohydrate yog qhov ruaj khov. Ua kom nce ntxiv ntawm cov tshuaj yog nqa qeeb, ntawm ntu ntawm ob peb hnub mus rau ib lis piam.

Qhov siab tshaj plaws txhua hnub koob:

• Maninil 1.75 - 6 ntsiav tshuaj,
• Maninil 3.5 thiab 5 - 3 ntsiav tshuaj.

Cov neeg mob uas tsis muaj zog, cov neeg muaj hnub nyoog siab, cov neeg mob uas tau txais kev noj zaub mov kom tsawg, ua rau lub siab lossis mob raum tsis ua haujlwm, thiab kev pib thiab txij nkawm yuav tsum tau txo, vim tias muaj kev pheej hmoo ntawm lub qog ntshav qab zib.

Cov ntsiav tshuaj yuav tsum tau noj ua ntej noj mov. Yog tias qhov koob tshuaj txhua hnub muaj 1-2 ntsiav tshuaj, feem ntau lawv noj ib hnub ib zaug - thaum sawv ntxov, ua ntej noj tshais. Cov koob tshuaj ntau dua yuav tsum tau faib ua ob zaug - noj thaum sawv ntxov thiab yav tsaus ntuj.

Yog tias tus neeg mob rau qee qhov tsis nco qab siv koob tshuaj ntxiv, koj yuav tsum haus cov ntsiav tshuaj thaum lub sijhawm ib txwm ua. Coj koob tshuaj ob zaug yog txwv tsis pub!

Sab sij huam

Raws li kev kuaj xyuas neeg mob, Maninil yuav muaj kev phiv tshuaj, xws li:

• Hyperthermia, kev tshaib plab, nkees, tachycardia, tsis muaj zog, ua kom tsis muaj kev sib koom tes ntawm kev txav, mob taub hau, vaum ntawm daim tawv nqaij, tshee tshee, zoo li kev ntshai, kev ntxhov siab, hloov mus rau hauv lub hlwb tsis zoo, nce phaus (los ntawm sab ntawm cov metabolism),
• Xeev siab, duav, hnov ​​qhov hnyav ntawm lub plab, mob plab, ntuav, nws yog xim hlau hauv qhov ncauj, raws plab (los ntawm lub plab zom mov),
• Kab mob siab, mob siab cholestasis, kev nce ntxiv ib ntus hauv kev ua haujlwm ntawm daim siab ua kom ntshav siab (los ntawm cov kab mob plab thiab nplooj siab),
• Khaus, petechiae, urticaria, photosensitization, kev tsis haum vasculitis, purpura, anaphylactic shock, cov tshuaj tiv thaiv tsis haum, nrog rau ua npaws, ua pob rau ntawm daim tawv nqaij, proteinuria, mob caj pas thiab mob daj ntseg (los ntawm lub cev tiv thaiv kab mob),
• Thrombocytopenia, pancytopenia, agranulocytosis, leukopenia, hemolytic anemia, erythropenia (los ntawm cov kab mob hematopoietic).

Tsis tas li ntawd, Maninil tuaj yeem ua rau muaj diuresis ntau dua, pom kev tsis txaus siab, kev ua kom haum xeeb, hyponatremia, hloov cov proteinuria, hla kev tsis haum rau probenecis, sulfonamides, sulfonylurea derivatives thiab diuretic npaj muaj sulfonamide pawg hauv cov qauv.