Cov tshuaj tiv thaiv ntshav siab ntshav siab Starlix

Starlix yog cov tshuaj hypoglycemic los ntawm phenylalanine amino acids. Cov tshuaj pab txhawb kom muaj zog tshaj tawm cov tshuaj hormone insulin 15 feeb tom qab tus neeg tau noj, thaum lub cev hloov hauv cov piam thaj hauv ntshav tau yoo tawm.

Ua tsaug rau txoj haujlwm no, Starlix tsis tso cai rau kev txhim kho ntshav qab zib yog tias, piv txwv li, ib tug neeg tau plam tsis noj mov. Cov tshuaj muaj muag nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj; txhua ntawm lawv muaj 60 lossis 120 mg ntawm cov tshuaj nquag nateglinide.

Kuj suav nrog yog magnesium stearate, titanium dioxide, lactose monohydrate, macrogol, liab hlau oxide, croscarmellose sodium, talc, povidone, microcrystalline cellulose, colloidal anhydrous silicon dioxide, hypromellose. Koj tuaj yeem yuav cov tshuaj ntawm lub khw muag tshuaj lossis cov khw tshwj xeeb, hauv pob 1, 2 lossis 7 lub hlwv, ib lub hlwv muaj 12 ntsiav tshuaj.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

· Anhydrous silicon dioxide (colloidal),

Titanium dioxide E171,

Hypromellose.60Hauv pob ntawv cardboard tej zaum yuav muaj 1, 2, 5, 7, 10, 30 hlwv ntawm 12 ntsiav tshuaj txhua. Dawb cov ntsiav tshuaj hauv lub plhaub daj, khij STARLIX rau ntawm sab xub ntiag. Sab nraub qaum - qhov tshuaj ntawm cov tshuaj "120".120 Cov ntsiav tshuaj nrog inscription STARLIX - ntawm ib sab tes thiab kos cim "180" - nyob rau sab nraud. Cov ntsiav tshuaj liab muaj cov zaj duab xis txheej, oval cov duab thiab cov xim liab.180

Pharmacological kev txiav txim

Nateglinide yog ib qho phenylalanine derivative. Qhov tshuaj ntawd rov ua kom pib tsim cov tshuaj insulin. Kev nce hauv cov tshuaj hormones concentration txhawb cov qib ntawm cov piam thaj thiab glycosylated hemoglobin A1C.

Kev ua cov tshuaj hormones ntau dua zoo rau 15 feeb tom qab noj mov. Lub sijhawm tom ntej 3.5 teev, insulin qib rov qab rau nws qhov qub, tsis txhob hyperinsulinemia.

TSEEM CEEB Kev zais ntshis ntawm cov tshuaj insulin yuav ncaj qha nyob ntawm kev saib xyuas ntawm cov piam thaj hauv cov ntshav.

Lub peev xwm ntawm cov tshuaj, txawm tias nyob rau hauv qhov txo qis hauv lub cev, los tswj cov qib ntawm qhov hormone tso cai rau koj los tiv thaiv qhov tshwm sim ntawm kev mob ntshav qab zib nrog kev qias ntawm lub cev, tus neeg mob tsis kam noj.

Qhia txog ntawm cov tshuaj

Cov tshuaj muaj kev tshuaj xyuas zoo. Nws pab kho cov tshuaj insulin thaum ntxov, nrog rau kev txo qis cov ntshav qab zib thiab glycated hemoglobin.

Xws li lub tshuab ntawm kev nqis tes ua yog qhov tseem ceeb rau cov neeg mob ntshav qab zib, vim tias cov ntshav hauv cov ntshav hauv lub cev yog qhov loj dua. Hauv cov kab mob ntshav qab zib mellitus, qhov theem ntawm cov kua dej tso kua mis muaj kev cuam tshuam, thaum nateglinide, uas yog ib feem ntawm cov tshuaj, pab kho kom rov ua ntu zus thaum pib ntawm hormone.

Tsis zoo li cov tshuaj zoo sib xws, Starlix pib pib tsim cov tshuaj insulin hauv 15 feeb tom qab noj mov, uas txhim kho cov mob ntshav qab zib thiab ua rau lub cev tsis zoo rau cov ntshav qabzib hauv cov ntshav.

1. Dhau plaub teev tom ntej, cov tshuaj insulin rov qab mus rau lawv tus nqi qub, qhov no pab tiv thaiv qhov tshwm sim ntawm postprandial hyperinsulinemia, uas yav tom ntej yuav ua rau muaj kev txhim kho kab mob ntshav qab zib.
2. Thaum cov piam thaj concentration txo qis, kev tsim tawm hauv insulin tsawg dua. Cov tshuaj, nyeg, tswj cov txheej txheem no, thiab nrog cov piam thaj tsis muaj txiaj ntsig, nws muaj qhov cuam tshuam tsis zoo rau lub cev xeeb tub. Qhov no yog lwm qhov zoo uas tsis tso cai rau kev txhim kho hypoglycemia.
3. Yog tias Starlix tau siv ua ntej noj mov, cov ntsiav tshuaj cuam sai sai rau lub plab zom mov. Qhov siab tshaj plaws ntawm cov tshuaj tshwm sim nyob rau hauv lub xuaj moos tom qab.

Tus nqi ntawm cov tshuaj yog nyob ntawm qhov chaw ntawm lub tsev muag tshuaj, yog li nyob rau hauv Moscow thiab Foros tus nqi ntawm ib pob ntawm 60 mg yog 2300 rubles, ib pob hnyav 120 mg yuav raug nqi 3000-4000 rubles.

Cov tshuaj Starlix: cov lus qhia rau kev siv

Txawm hais tias qhov tseeb tias cov tshuaj muaj kev tshuaj xyuas zoo, nws yog ib qho tsim nyog tham nrog koj tus kws kho mob ua ntej siv cov tshuaj.

Cov ntsiav tshuaj yuav tsum noj 30 feeb ua ntej noj mov. Rau kev kho mob tas li nrog cov tshuaj no ib leeg, qhov tshuaj noj yog 120 mg peb zaug ib hnub ua ntej noj mov.

Thaum tsis tuaj yeem pom kev siv tshuaj kho, qhov tshuaj tuaj yeem nce ntxiv mus rau 180 mg.

Thaum lub sij hawm kho cov neeg mob, tus neeg mob yuav tsum tswj cov ntshav qab zib cov ntshav thiab kho cov koob tshuaj raws li cov ntaub ntawv tau txais. Yuav kom ntsuas seb cov tshuaj muaj txiaj ntsig zoo npaum li cas, kuaj ntshav rau cov ntsuas ntawm qabzib yog kwv yees li ib mus rau ob teev tom qab noj mov.

Qee zaum ib tus neeg sawv cev hypoglycemic ntxiv tau ntxiv rau yeeb tshuaj, feem ntau Metformin. Xws li Starlix tuaj yeem ua cov cuab yeej ntxiv hauv kev kho mob ntawm Metformin. Hauv qhov no, nrog qhov txo qis thiab kwv yees ntawm qhov xav tau HbA1c, kev noj tshuaj ntawm Starlix yog txo rau 60 mg peb zaug ib hnub.

Nws yog ib qho tseem ceeb uas yuav tsum xav txog tias cov ntsiav tshuaj muaj qee yam contraindications. Hauv qee qhov, koj tsis tuaj yeem siv cov tshuaj nrog:

• Kev ua haujlwm tsis zoo
• Ntshav qab zib mob ntshav insulin-tiv thaiv ntshav qab zib,
• Kev mob siab rau daim siab hnyav,
• Ketoacidosis.
• Tsis tas li, kev kho mob yog ua rau mob me nyuam yaus, thaum cev xeeb tub thiab lactation.

Qhov ntau npaum no tsis tas yuav hloov kho yog tias tus neeg mob ib txhij noj Warfarin, Troglitazone, Diclofenac, Digoxin. Tsis tas li, tsis muaj kev cuam tshuam loj ntawm lwm cov tshuaj tiv thaiv kab mob ntshav siab tau qhia tawm.

Cov tshuaj xws li Captopril, Furosemide, Pravastatin, Nicardipine. Phenytoin, Warfarin, Propranolol, Metformin, Acetylsalicylic acid, Glibenclamide tsis cuam tshuam rau kev cuam tshuam ntawm nateglinide nrog cov protein.

Nws yog ib qho tseem ceeb kom nkag siab tias qee yam tshuaj ua rau muaj cov metabolism hauv qabzib, yog li ntawd, thaum noj lawv nrog cov tshuaj hypoglycemic, hloov cov piam thaj hauv siab.

Hauv qee qhov, hypoglycemia hauv cov ntshav qab zib mellitus yog txhim kho los ntawm salicylates, tsis xaiv-beta-blockers, NSAIDs thiab MAO inhibitors. Cov tshuaj Glucocorticoid, thiazide diuretics, sympathomimetics thiab cov thyroid hormones pab ua rau cov ntshav qog ua kom tsis muaj zog.

1. Ntawm hom 2 mob ntshav qab zib mellitus, yuav tsum tau saib xyuas tshwj xeeb, vim tias qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia yog qhov siab heev. Hauv kev tshwj xeeb, nws yog qhov tseem ceeb uas yuav tau soj ntsuam cov ntshav qab zib kom qis rau cov neeg ua haujlwm nrog cov txheej txheem nyuaj lossis tsav tsheb.
2. Cov neeg tsis tshua muaj mob, cov laus neeg, cov neeg mob uas pom tias qog nqaij hauv lub cev lossis qog tsis txaus ua rau poob rau hauv thaj chaw pheej hmoo. Ntshav qab zib tuaj yeem txo qis yog tias ib tus neeg haus cawv, ntsib kev tawm dag zog lub cev, thiab tseem yuav siv lwm cov tshuaj tiv thaiv ntshav qab zib.
3. Thaum kho, tus neeg mob yuav muaj kev phiv ntau dua nyob rau hauv daim ntawv ntawm kev tawm hws, tshee, kiv taub hau, nce siab, nce lub plawv dhia, xeev siab, tsis muaj zog thiab malaise.
4. Cov concentration ntawm cov piam thaj hauv cov ntshav yuav qis dua 3.3 mmol / litre. Feem ntau tsis tshua muaj tshwm sim, kev ua si ntawm daim siab enzymes hauv cov ntshav nce ntxiv, kev tawm tsam tsis haum, nrog ua pob liab vog, khaus thiab urticaria. Mob taub hau, raws plab, dyspepsia, thiab mob plab kuj ua tau.

Khaws cov tshuaj cia hauv chav sov, kom deb ntawm kev tshav ntuj ncaj qha thiab menyuam yaus. Txee lub neej yog peb xyoos, yog tias lub sijhawm cia thau tawm, cov tshuaj pov tseg thiab tsis siv rau nws lub hom phiaj.

Analogues ntawm cov tshuaj

Rau cov tshuaj nquag, ua tiav analogues ntawm cov tshuaj tsis muaj nyob. Txawm li cas los xij, niaj hnub no nws muaj peev xwm yuav cov tshuaj uas muaj cov teebmeem zoo sib xws uas tswj cov ntshav qab zib thiab tsis txhob cia cov ntshav qog ntshav qab zib.

Novonorm ntsiav tshuaj noj rau hom ntshav qab zib hom 2, yog tias noj tshuaj pab rau lub cev, ua kom yuag thiab lub cev tsis pab ua kom tus neeg mob lub cev tsis zoo. Txawm li cas los xij, xws li cov tshuaj no yog contraindicated nyob rau hauv hom 2 mob ntshav qab zib mellitus, mob ntshav qab zib ketoacidosis, mob ntshav qab zib precoma thiab coma, thiab mob siab tsis ua haujlwm. Tus nqi ntawm kev ntim cov ntsiav tshuaj yog 130 rubles.

Cov tshuaj Diagnlinide siv rau hom 2 mob ntshav qab zib mellitus, ua ke nrog Metformin, yog tias nws tsis tuaj yeem ua kom cov ntshav qabzib nyob rau hauv kev ntsuas los ntawm cov qauv txheej txheem.

Cov tshuaj yog contraindicated nyob rau hauv hom 1 mob ntshav qab zib mellitus, mob ntshav qab zib ketoacidosis, mob ntshav qab zib precoma thiab coma, kab mob kis, kev cuam tshuam kev phais thiab lwm yam mob uas xav tau kev kho mob insulin. Tus nqi ntawm cov tshuaj tawm 250 rubles.

Cov tshuaj Glibomet yog noj rau ntshav qab zib hom 2. Qhov ntau npaum li cas yog xaiv tau ib tus zuj zus, nyob ntawm seb qhov metabolism.

Cov tshuaj yog contraindicated nyob rau hauv kev mob ntshav qab zib ketoacidosis thiab yam 1 mob ntshav qab zib mellitus, lactic acidosis, mob ntshav qab zib precoma thiab coma, hypoglycemia, hypoglycemic coma, mob siab lossis raum tsis ua haujlwm, thiab kis kab mob. Koj tuaj yeem yuav qhov cuab yeej ntawd rau 300 rubles.

Cov tshuaj Glucobai zoo rau hom 1 thiab ntshav qab zib hom 2. Qhov siab tshuaj ntau tshaj plaws txhua hnub yog 600 mg rau ib hnub. Cov tshuaj tau noj yam tsis muaj kev zom, nrog dej me me, ua ntej noj mov lossis ib teev tom qab noj mov. Tus nqi ntawm ib pob ntawm cov ntsiav tshuaj yog 350 rubles.

Hauv daim vis dis aus hauv tsab xov xwm no, kws kho mob yuav muab lus qhia txog yuav ua li cas kom txo qis ntshav qab zib thiab rov ua kom cov kua dej tsis zais.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, nateglinide yog nqus rau hauv txoj hnyuv me, nce mus txog qhov siab tshaj plaws hauv tsawg dua ib teev. Bioavailability ntawm 72%. Lub sijhawm yuav ncav cuag Cmax yog kev ywj siab ntawm cov tshuaj. Kev noj tshuaj nrog zaub mov ua rau nws nyuaj rau nqus cov tshuaj. Bioavailability tsis hloov.

Nateglinide khi rau cov plasma protein li 98%.

Cov tshuaj muaj zog ua rau lub cev hloov pauv hauv lub siab nrog kev koom tes nrog cytochrome P450 isoenzymes. Thaum ua tiav ntawm cov tshuaj tiv thaiv ntawm kev sib ntxiv ntawm cov pab pawg hydroxyl, peb lub hauv paus pib ntawm cov tshuaj nquag tau tsim, uas yog cov quav tawm los ntawm lub raum. 7-16% ntawm thawj zaug tshuaj noj tsis tau hloov pauv. Nrog kev quav, lwm 10% ntawm cov khoom tawm hauv lub cev. Ib nrab-lub neej ntawm Starlix yog li ib teev thiab ib nrab.

Hom 2 mob ntshav qab zib mellitus nrog kev ua kom lub cev qis thiab kev kho kev noj haus.

Cov chaw muag tshuaj

Ntxov tso kua mis thaum ntxov nyob rau hauv kev teb rau cov piam thaj yog tus txheej txheem tseem ceeb rau kev tswj cov ntshav khov hauv lub cev. Ntawm hom 2 mob ntshav qab zib mellitus, qhov ua txhaum / qhaj ntawm no theem ntawm insulin secretion. Nyob hauv kev cuam tshuam ntawm nateglinide noj ua ntej noj mov, thaum ntxov (lossis thawj) theem ntawm cov kua dej tso kua mis rov qab. Cov txheej txheem ntawm qhov tshwm sim no yog qhov nrawm thiab thim rov qab kev sib cuam tshuam ntawm cov tshuaj nrog K + -ATP-tso raws cov of-hlwb ntawm cov txiav. Qhov xaiv ntawm nateglinide nrog kev hwm K + -ATP-tso raws kev ua haujlwm ntawm pancreatic cells-cell yog 300 npaug ntau dua qhov uas hais txog kev saib xyuas cov feem ntawm lub plawv thiab cov hlab ntsha.

Qeb tsis sib thooj, tsis zoo li lwm yam kev tiv thaiv kab mob hauv lub qhov ncauj, ua rau cov kua dej hauv thaj tsam thawj 15 feeb tom qab noj mov, vim tias cov kev cuam tshuam tom qab ("peaks") hauv cov ntshav qabzib concentration yog smoothed. Hauv 3-4 teev tom ntej no, cov tshuaj insulin rov qab los rau nws cov nqi qub, yog li zam txoj kev txhim kho ntawm postprandial hyperinsulinemia, uas tuaj yeem ua rau cov ntshav qog ntshav qab zib qeeb.

Kev zais ntawm cov kua dej los ntawm the-hlwb ntawm cov txiav ua los ntawm nateglinide yog nyob ntawm seb cov piam thaj hauv cov ntshav siab li cas, uas yog, vim cov piam thaj cov ntshav tsis txaus, insulin secretion tsawg. Hloov siab, kev sib txig kev noj mov lossis kev ua txhaum ntawm cov dej qabzib ua rau cov kua dej hauv lub zais insulin ntau ntxiv. Muaj peev xwm Starlix ntawm cov ntsiab lus tsawg kawg ntawm cov piam thaj hauv cov ntshav, qhov tseem ceeb tsis txaus ntseeg ntawm insulin secretion yog ib qho ntxiv los tiv thaiv kev txhim kho ntawm hypoglycemia, piv txwv li, thaum tsis noj mov.

Xuas. Thaum noj cov ntsiav tshuaj Starlix ua ntej noj mov, nateglinide nrawm nrawm los ntawm lub plab zom mov. Lub sijhawm nce mus txog Cmax tsawg dua li 1 teev. Kev ntsuas kev noj qab haus huv ntawm cov tshuaj yog kwv yees li 72%. Rau cov ntsuas xws li AUC thiab Cmax, lub chaw muag tshuaj ntawm nateglinide ntau ntau hauv 60 mg txog 240 mg yog linear hauv cov neeg mob uas muaj ntshav qab zib hom 2 zaug 3 zaug / hnub rau ib lub lis piam.

Kev xa Khoom. Qhov khi ntawm nateglinide rau cov ntshiab protein (feem ntau nrog albumin, kom tsawg li tsawg - nrog cov kua qaub α1-glycoprotein) yog 97-99%. Kev nqus ntawm cov protein khi tsis yog nyob ntawm qhov kev txiav txim siab ntawm nateglinide nyob rau hauv cov ntshav hauv qhov kawm txog 0.1-10 μg / ml. Vd thaum ncav mus sib npaug yog li 10 liv.

Kev zom zaub mov. Nateglinide yog qhov ua kom zoo hauv lub siab nrog kev koom tes ntawm microsomal isoenzymes ntawm cytochrome P450 (70% isoenzyme CYP2C9, 30% CYP3A4). Lub 3 lub cev tseem ceeb ntawm nateglinide uas ua los ntawm cov kev siv tshuaj hydroxylation muaj ntau zaus qis kev ua haujlwm ntawm pharmacological piv rau cov pib khoom.

Chaw Sau Ntawv. Nateglinide raug tshem tawm ntawm lub cev sai heev - thaum thawj 6 teev tom qab noj, kwv yees li 75% ntawm cov tshuaj tau tawm hauv cov zis. Kev zam tawm yog nqa tawm feem ntau nrog cov zis (kwv yees li 83% ntawm koob tshuaj), feem ntau yog siv tshuaj metabolites. Li 10% yog nyob hauv cov quav. Hauv qhov kev kawm txog ntau npaum li cas (txog li 240 mg 3 zaug / hnub), tsis pom zoo li. T1 / 2 yog 1.5 teev.

Thaum sau tshuaj nateglinide tom qab noj mov, nws qhov nqus tau poob qis - Tmax lengthens, Cmax poob qis, thaum qhov ua tiav ntawm kev nqus (AUC tus nqi) tsis hloov. Nyob rau hauv kev sib txuas nrog lub dhau los, nws raug pom zoo kom ua ntawv thov Starlix ua ntej noj mov.

Tsis muaj qhov sib txawv hauv tsev kho mob hauv qhov chaw muag tshuaj ntawm nateglinide hauv cov txiv neej thiab poj niam cov neeg mob.

Cov lus qhia tshwj xeeb. Tshuaj ua Starlix beta-blockers nce .Thaum noj Starlix, koj yuav tsum tsis txhob haus cawv, vim tias qhov no tuaj yeem ua rau muaj kev txhim kho cov kev mob tshwm sim.

Txoj kev ntawm daim ntawv thov

Starlix yuav tsum noj ua ntej noj mov. Lub sijhawm sib nrug ntawm kev noj tshuaj thiab noj mov yuav tsum tsis pub ntau tshaj 30 feeb. Raws li txoj cai, siv yeeb tshuaj tam sim ntawd ua ntej noj mov.

Thaum siv Starlix raws li kev kho mob monotherapy, qhov koob tshuaj pom zoo yog 120 mg 3 zaug / hnub (ua ntej noj tshais, noj su thiab noj hmo).

Metformin kuj tseem raug teeb meem rau cov neeg mob uas tau txais Starlix monotherapy thiab xav tau lwm yam tshuaj hypoglycemic. Ntawm qhov tsis sib xws, cov neeg mob uas twb tau txais kev kho mob metformin tuaj yeem raug kho Starlix ntawm koob tshuaj 120 mg 3 zaug / hnub (ua ntej noj mov) ua ib qho khoom siv ntxiv. Yog tias, tawm tsam cov keeb kwm yav dhau los ntawm kev kho mob metformin, HbA1c tus nqi nce mus rau qhov txiaj ntsig xav tau (tsawg dua 7.5%), qhov koob tshuaj ntawm Starlix yuav tsawg dua - 60 mg 3 zaug / hnub.

Tsis muaj qhov sib txawv ntawm kev ua tau zoo thiab kev nyab xeeb ntawm Starlix hauv cov neeg laus thiab cov neeg pej xeem. Tsis tas li ntawd, lub hnub nyoog ntawm cov neeg mob tsis cuam tshuam qhov pharmacokinetic tsis haum ntawm Starlix. Yog li, rau cov neeg laus cov neeg mob, yuav tsum tau kho tshwj xeeb ntawm cov tshuaj ntau npaum li cas tsis tas yuav tsum tau ua.

Qhov ua tau zoo thiab kev nyab xeeb ntawm Starlix hauv cov menyuam tseem tsis tau kawm, yog li nws qhov kev teem sijhawm tsis pom zoo rau menyuam yaus.

Hauv cov neeg mob uas muaj me ntsis mus rau mob nyhav hepatic, kev hloov tshuaj tsis tas yuav tsum tau ua. Nws tsis pom zoo kom siv cov tshuaj hauv cov neeg mob uas muaj mob hepatic hnyav, vim tias tsis muaj cov ntaub ntawv los ntawm kev tshawb fawb soj ntsuam.

Hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm txawv (suav nrog cov mob ntawm hemodialysis), ntau npaum li kev kho lub cev tsis tas yuav tsum ua.

Cov Yuav Tsum Muaj

yam kuv mob ntshav qab zib

Kev cuam tshuam nrog lwm yam tshuaj

Hauv cov kev tshawb fawb hauv vitro pom tau tias nateglinide yog cov metabolized ntau los ntawm cytochrome P450 isoenzymes - CYP2C9 (70%) thiab CYP3A4 (30%).

Nateglinide tsis cuam tshuam rau lub pharmacokinetic khoom ntawm warfarin (qhov tsis txaus rau CYP3A4 thiab CYP2C9), diclofenac (substrate rau CYP2C9), troglitazone (inducer ntawm CYP3A4) thiab digoxin. Yog li, nrog tib lub sijhawm teem caij Starlix thiab cov tshuaj xws li warfarin, diclofenac, troglitazone thiab digoxin tsis tas yuav siv tshuaj kho kom haum. Muaj kuj tsis muaj kev sib tshuam tseem ceeb ntawm cov chaw muag tshuaj Starlix nrog lwm cov tshuaj tiv thaiv kab mob hauv qhov ncauj xws li metformin thiab glibenclamide.

Txij li nateglinide muaj siab khi rau plasma protein, hauv kev tshawb hauv vitro tau kawm txog nws txoj kev cuam tshuam nrog ntau cov tshuaj muaj protein ntau, xws li furosemide, propranolol, captopril, nicardipine, pravastatin, warfarin, phenytoin, acetylsalicylic acid, glibenclamide thiab metformin. Nws tau qhia tias cov tshuaj no tsis cuam tshuam rau kev sib txuas ntawm nateglinide nrog cov plasma protein. Zoo sib xws, nateglinide tsis tshem tawm propranolol, glibenclamide, nicardipine, warfarin, phenytoin, thiab acetylsalicylic acid los ntawm khi rau cov protein.

Nws yuav tsum tau yug los rau hauv lub siab tias qee cov tshuaj muaj feem cuam tshuam rau cov metabolism hauv qabzib, yog li ntawd, thaum lawv ib txhij kho cov tshuaj hypoglycemic, suav nrog Starlixkev hloov pauv hauv cov piam thaj hauv kev ua tau thiab kev saib xyuas kev noj qab haus huv yuav tsum muaj. Kev ua rau lub ntsej muag tuaj yeem ua kom zoo dua qub nrog kev tswj hwm tib lub sijhawm ntawm NSAIDs, salicylates, MAO inhibitors, tsis xaiv-beta-blockers. Ntawm qhov tsis sib thooj, cov nyhuv hauv lub ntsej muag tuaj yeem tsis muaj zog nrog kev tswj hwm tib lub sijhawm ntawm thiazide diuretics, glucocorticoids, sympathomimetics, thiab kev npaj cov thyroid hormones.

Noj ntau dhau

Ntau tus neeg mob Starlix tseem tsis tau piav.

Cov tsos mob: raws li kev paub ntawm cov txheej txheem ntawm kev ua ntawm cov tshuaj, nws tuaj yeem xav tias qhov tseem ceeb tshaj plaws ntawm kev haus ib qho zuj zus yuav yog hypoglycemia nrog kev soj ntsuam cov tsos mob ntawm txawv txav.

Kev Kho Mob: Cov hau kev rau kev kho ntshav qab zib yog txiav txim siab los ntawm qhov mob hnyav ntawm cov tsos mob. Nrog rau txoj kev saib xyuas zoo thiab tsis muaj qhov mob ntawm lub paj hlwb, cov ntshav qabzib / piam thaj kev ua kom haum yog qhia, nrog rau kev txhim kho koob tshuaj thiab / lossis noj mov. Hauv cov ntshav qog ntshav qab zib heev, nrog mob paj hlwb (hnov tsis meej, qaug dab peg), muaj cov kua dej qabzib rau lub cev. Kev siv hemodialysis los tshem tawm nateglinide los ntawm cov hlab ntshav yog qhov tsis muaj txiaj ntsig vim nws qhov siab khi rau cov ntshav protein.

Cia rau cov neeg mob

Cov tshuaj yuav tsum khaws cia ntawm qhov kub tsis tshaj 30 ° C hauv nws cov khoom ntim thawj, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam yaus.

1 lub ntim zaj duab xis-txheej muaj:

• cov tshuaj nquag: nateglinide 60 thiab 120 mg,
• kev zam: lactose monohydrate, microcrystalline cellulose, povidone, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide (E171), talc, macrogol, anhydrous colloidal silicon dioxide, liab hlau oxide (E172).

Yeem

Thaum siv Starlix rau kev kho mob ntawm cov neeg mob ntshav qab zib hom 2 mob ntshav qab zib mellitus (non-insulin-dependant), kev ceev faj txog kev tshwm sim ntawm kev mob ntshav qab zib yuav tsum tau soj ntsuam. Txoj kev pheej hmoo ntawm kev txhim kho hypoglycemia thaum noj Starlix (zoo li lwm yam tshuaj hypoglycemic) yog ntau dua rau cov neeg mob laus uas txo lub cev hnyav thaum muaj cov qog adrenal lossis pituitary tsis txaus. Kev txo qis ntshav qabzib hauv lub ntsej muag tuaj yeem tshwm sim los ntawm kev haus dej haus cawv, ua kom lub cev muaj zog, nrog rau kev siv lwm cov tshuaj tiv thaiv ntshav qab zib hauv lub cev.

Kev siv cov beta-blockers ib txhij tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Cov neeg mob ua haujlwm nrog kev siv tshuab thiab tsav tsheb yuav tsum ceev faj cov kev tiv thaiv kom tsis txhob mob ntshav qab zib.

Sab sij huam

Kev txais tos tuaj yeem ua rau qhov kev tsis txaus siab hauv qab no:

• Xeev siab thiab tsis muaj zog
• Tsis qab los noj mov
• Qaug zog thiab kiv taub hau,
• Muaj hws ntau
• Mob siab rau cov nqua.

Cov tsos mob tshwm sim hauv cov neeg mob uas muaj cov ntshav qabzib tsawg dua 3.4 mmol / L. Kis nrog qab zib.

Tsis tshua muaj qhov tshwm sim yog tawm pob ua xua thiab ua pob liab liab ntawm daim tawv nqaij, qee zaum muaj qhov nce ntxiv hauv kev ua haujlwm ntawm daim siab enzymes.

Yeeb tshuaj sib cuam tshuam

Starlix suppresses cov nyhuv ntawm tolbutamide.

Nateglinide tsis cuam tshuam nrog cytochrome substrates:

• rau CYP2C9 - diclofenac,
• rau CYPЗА4 thiab CYP2С9 - warfarin.

Kuj tseem tsis tau pom muaj digoxin, troglitazone.

Lub cuab yeej tsis cuam tshuam rau qhov kev ua ntawm metformin thiab glibenclamide. Beta-blockers tuaj yeem npog cov tsos mob ntawm kev mob ntshav qab zib.

Nws muaj peev xwm ua tiav qhov kev nce ntxiv hauv cov nyhuv ntawm nateglinide thaum noj monooxidase inhibitors (MAOs), tsis siv tshuaj tiv thaiv tsis haum tshuaj thiab salicylates. Glucocorticosteroids, cov thyroid hormones, sympathomimetics, thiazide diuretics txo cov nyhuv. Hauv qhov no, nws yog ib qho tsim nyog yuav tsum tau tswj hwm qhov nruj ntawm cov piam thaj.

Tsis muaj kev txhim kho ntxiv ntawm kev coj ua txhua hnub yog xav tau thaum siv sib txuas nrog cov tshuaj uas nquag khi rau cov ntshav plasma (acetylsalicylic acid, captopril, nicardipine, propranolol, furosemide).

Kev siv Starlix tib lub sijhawm nrog lwm cov tshuaj ntawm hypoglycemic ua tuaj yeem ua rau poob qis hauv qab zib.

Cov lus qhia tshwj xeeb

Kev haus dej haus cawv thiab ua kom lub cev tawm dag zog ntau tuaj yeem ua rau lub cev muaj ntshav qab zib tsawg.

Tom qab ob teev tom qab noj mov, nws raug nquahu kom ua qhov ntshav rau cov ntshav qab zib.

TSEEM CEEB! Cov tshuaj muaj feem cuam tshuam rau kev tswj hwm lub tsheb, yog li ntawd, cov tsav tsheb thiab cov neeg uas lawv txoj haujlwm tau txuam nrog kev tswj hwm ntawm kev siv, yuav tsum ua tib zoo saib.

Yuav siv tau ua ke nrog lwm cov tshuaj hypoglycemic - piv txwv li, metformin. Tsis tas li, tus kws kho mob muaj cai sau ntawv rau Starlix raws li kev xav kho.

Piv nrog analogues

“Tsis ntev los no, Kuv tau pib haus dej ntau, nqhis dej tau dhau mus, tsis muaj laj thawj kuv pib khaus, ntshav nce siab. Kuv nyeem txog cov tsos mob, Kuv pom tias kuv muaj ntshav qab zib. Kuv mus cuag kws kho mob, kev kuaj mob paub tseeb. Lawv sau tawm Starlix. Cov tshuaj tsis pheej yig. Kuv txiav txim siab txawm li cas los ua raws li tus kws kho mob tau hais tseg. Ua ntej noj cov tshuaj, Kuv muaj piam thaj yog 12, tam sim no - 7. Kuv ntshav siab poob qis me ntsis, Kuv tau tso tseg kom tsis txhob khaus, tsis muaj nqhis dej. Hauv ib lo lus, tus mob tau hloov kho. Tab sis qhov tseem ceeb tshaj plaws yog ua raws li kev noj haus. "

Kostya 2016-09-15 14:11:37.

Starlix ntsiav tshuaj yog cov tshuaj muaj zog. Kuv yuav tsum tau haus nws nrog piam thaj saum toj no 10. Poob rau 3 ".

Antonina Egorovna 2017-12-11 20:00:08.

"Lawv tau sau tawm Maninil xyoo tas los. Tsis muaj qab zib zoo. Kuv tau mus ntsib lwm tus kws kho mob, lawv tau tawm Starlix. Kuv yuav tsum haus 2 ntsiav tshuaj ntawm 60 mg ua ke nrog Glucofage thaum sawv ntxov thiab ua ntej yuav mus pw. Kuv xav zoo. Qab zib thaum kawg rov qab los.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, tam sim ntawd ua ntej noj mov (lub sijhawm ntawm noj tshuaj thiab noj mov yuav tsum tsis pub ntau tshaj 30 feeb).

Nrog tshuaj kho mob, cov koob tshuaj pom zoo yog 120 mg 3 zaug hauv ib hnub (ua ntej noj tshais, noj su thiab noj hmo). Yog tias nws tsis tuaj yeem ua kom tiav cov txiaj ntsig uas xav tau, ib koob tshuaj ntxiv tau nce mus txog 180 mg.

Kev kho ntawm cov tshuaj ntau dua yog ua raws li tau txiav txim siab tas li glycosylated Hb qhov tseem ceeb. Muab hais tias cov txiaj ntsig tseem ceeb yog los txo cov ntshav qab zib cov ntsiab lus tom qab, cov ntshav qabzib nyob rau hauv 1-2 teev tom qab noj mov tuaj yeem siv los ntsuas qhov ntsuas kev ua tau zoo ntawm cov tshuaj.

Hauv kev sib xyaw ua ke, nateglinide yog tshuaj ntawm 120 mg 3 zaug ib hnub nyob rau hauv kev sib xyaw nrog metformin, yog tias tus nqi glycosylated Hb mus cuag tus nqi xav tau (tsawg dua 7.5%), qhov koob tshuaj tuaj yeem txo mus rau 60 mg 3 zaug ib hnub.

Thaum tsis ua hauj lwm zoo rau lub raum, kev hloov tshuaj ntau dua tsis tas yuav ua.