Cov tshuaj Lipantil: cov lus qhia rau kev siv

nyob rau hauv lub blister 10 pcs., nyob rau hauv ib pob ntawm cardboard 3 blisters.

Cov Tshuaj Hauv Tshuaj

Lowers triglycerides thiab, tsawg dua, cov roj (cholesterol) hauv cov ntshav. Nws pab txo cov ntsiab lus ntawm VLDL, kom tsawg dua - LDL, nce cov ntsiab lus ntawm anti-atherogenic HDL. Nws ua kom lipoprotein lipase thiab, yog li, cuam tshuam cov metabolism ntawm triglycerides, cuam tshuam kev sib txuas ntawm cov roj ntsha thiab cov roj cholesterol, thiab pab txhawm rau nce LDL receptors hauv lub siab. Fenofibrate txo platelet sib sau ua ke, txo qis ntshav plasma fibrinogen, tuaj yeem txo qis ntshav qabzib hauv cov neeg mob ntshav qab zib mellitus, thiab txo qis qib uric acid hauv cov ntshav.

Cov Tshuaj Pharmacokinetics

Lub ntsiab metabolite yog fenofibroic acid. Tom qab noj cov tshuaj hauv C_max hauv plasma nce mus txog tom qab 5 teev. Thaum noj ntawm ib koob tshuaj 200 mg, qhov nruab nrab ntshav plahaum yog 15 μg / ml. Lub plasma concentration ntawm cov tshuaj muaj zog. T_1/2 fenofibroic acid - txog 20 teev. Nws raug tso tawm ntau hauv cov zis (fenofibroic acid thiab nws cov glucuronide) tom qab 6 hnub. Nws tsis ntau ntxiv thaum noj ib koob thiab siv ntev heev. Fenofibroic acid tsis raug tawm thaum lub sij hawm hemodialysis.

Cov Yuav Tsum Muaj

Kev mob siab rau lub siab thiab lub raum kev ua haujlwm, keeb kwm ntawm phototoxic lossis photoallergic kev kho mob thaum kho nrog fenofibrates lossis lwm yam tshuaj zoo sib xws hauv cov qauv, tshwj xeeb tshaj yog ketoprofen, ua ke nrog rau lwm cov fibrates, cov menyuam yaus hnub nyoog qis dua 18 xyoo, cev xeeb tub, lactation, congenital galactosemia, lactase deficiency.

Sab sij huam

Diffuse myalgia, mob leeg nqaij, ua kom tsis muaj zog, thiab (hauv qee qhov mob tsawg) rhabdomyolysis, qee zaum mob hnyav. Thaum kev kho mob raug txiav tawm, cov xwm txheej no feem ntau yuav rov qab ua haujlwm.

Los ntawm cov hnyuv: dyspepsia. Ntxiv kev ua haujlwm ntawm hepatic transaminases hauv ntshav dej.

Kev tsis haum tshuaj: tsis tshua muaj - tawv nqaij ua pob khaus, khaus, urticaria, photosensitivity. Qee qhov xwm txheej (tom qab siv ntau lub hlis), kev hloov pauv qhov ntsej muag me me tuaj yeem tshwm sim hauv daim tawv nqaij erythema, papules, hlwv, lossis ua pob ua pob.

Kev sib txuam

Kev sib xyaw ua ke uas muaj contraindicated: nrog rau lwm cov fibrates, kev pheej hmoo ntawm cov kev mob tshwm sim (mob leeg).

Qhov tsis txaus ntseeg ua ke: nrog HMG-CoA reductase inhibitors - kev pheej hmoo ntawm kev mob tshwm sim (mob leeg).

Kev sib xyaw ua ke kom siv nrog ceev faj - nrog anticoagulants tsis ncaj (muaj kev pheej hmoo ntshav). Kev tswj fwm ntau zog ntawm PV yog qhov tsim nyog thaum xaiv cov koob tshuaj ntawm qhov tsis ncaj anticoagulant thaum kho mob nrog fibrates thiab tsis pub dhau 8 hnub tom qab lawv tshem tawm.

Fenofibrate tsis siv yooj yim nrog MAO inhibitors.

Kev tiv thaiv kev nyab xeeb

Muaj cov ntaub ntawv hais txog ntawm cov nyhuv ntawm fibrates rau cov leeg nqaij, nrog rau cov tsis tshua muaj mob necrosis. Cov txheej txheem no feem ntau tshwm sim nrog txo qis ntshav plasmain. Cov txiaj ntsig tau qhia yuav tsum raug coj los txiav txim siab hauv txhua tus neeg mob uas mob myalgia, mob nqaij thiab qhov nce ntawm creatine phosphokinase (5 zaug siab dua li ib txwm). Hauv cov xwm txheej no, txoj kev kho yuav tsum tsis ua mus ntxiv.

Ntxiv rau, qhov kev pheej hmoo ntawm cov leeg yuav muaj zog yog tias cov tshuaj tau sau nrog HMG-CoA reductase inhibitors.

Vim tias muaj lactose, cov tshuaj yog contraindicated hauv plab galactosemia, nyob rau hauv cov ntaub ntawv ntawm cov piam thaj thiab galactose malabsorption syndrome lossis thaum lactase tsis txaus.

Yog tias qhov txaus siab txo qis hauv cov ntshav lipids tsis tau txais thaum lub sijhawm cov tshuaj 3-6 lub hlis, yuav tsum tau siv txoj hauv kev kho kom zoo sib txawv.

Kev soj ntsuam kab ke hauv theem ntawm hepatic transaminases nyob rau hauv cov ntshav ntshav txhua 3 lub hlis thaum thawj 12 lub hlis ntawm kev kho yog tsim nyog. Yog tias theem ntawm AST thiab ALT nce ntxiv los ntawm ntau tshaj 3 zaug piv nrog VGN, kev kho yuav tsum tsis ua ntxiv.

Thaum ua ke ntawm cov tshuaj tiv thaiv tsis tau, kev saib xyuas ntawm cov ntshav coagulation system yog qhov tsim nyog.

Pharmacological kev txiav txim

Hypolipidemic tus neeg sawv cev, muaj cov nyhuv uricosuric thiab antiplatelet. Txo cov roj ntshav tag nrho los ntawm 20-25%, ntshav TG los ntawm 40-45% thiab uricemia los ntawm 25%. Nrog lub sijhawm ntev kho kom zoo, txo cov roj cov ntshav tawm hauv lub cev yog txo qis.

Txo cov ntsiab lus ntawm TG, VLDL, LDL (kom tsawg dua), nce - HDL, cuam tshuam kev tsim ntawm cov roj fatty acids. Txo cov platelet sib sau ua ke, txo cov ntshav plasma fibrinogen ntau dua. Hauv cov neeg mob ntshav qab zib muaj qee cov nyhuv hypoglycemic.

Cov lus qhia tshwj xeeb

Txoj kev kho yuav tsum tau ua nrog kev sib xyaw nrog kev noj zaub mov zoo thiab nyob hauv kev saib xyuas ntawm tus kws kho mob.

Thaum tsis muaj qhov ua tau zoo txaus siab tom qab 3-6 lub hlis ntawm kev tswj hwm, concomitant lossis lwm txoj kev kho tuaj yeem raug kho.

Nws raug nquahu kom soj ntsuam cov haujlwm ntawm "hepatic" hloov pauv txhua 3 lub hlis nyob rau thawj xyoo ntawm kev kho, kev so ib ntus hauv kev kho yog tias lawv cov haujlwm nce ntxiv, thiab tsis suav nrog kev kho mob ib yam li cov tshuaj hepatotoxic.

Muaj pes tsawg leeg thiab noj ntau npaum

Cov tshuaj Lipantil 200 m belongs rau cov chaw tsim tshuaj ntawm cov tshuaj fibroic acid. Lub ntsiab nquag khoom sib xyaw yog fenofibrate. Nws ua rau PPA-α receptors, ua kom muaj kev ua ntawm lipoprotein lipase. Txoj kev no nrawm cov txheej txheem ntawm kev sib cais roj thiab tshem tawm cov roj triglyceride los ntawm cov ntshav. Yog li, qib ntawm lipoproteins tsawg ntom yog txo los ntawm qhov tsis ncaj, thiab tus lej ntawm lipoproteins ntau ntom ntom nti, ntawm qhov tsis sib thooj, nce ntxiv. Fibrate kuj ncaj qha rau cov ntshav qab zib kom qis. Cov tshuaj pab ua rau kom muaj nuj nqis ntawm fibrinogen, tiv thaiv kev tsim cov ntshav txhaws.

Daim ntawv tso tawm ntawm Lipantil yog tawv tawv ua kua roj gelatin capsule uas muaj cov nplawm dawb hauv. Cov tshuaj muaj nyob hauv ib qhov tshuaj 200 mg, 30 daim ib pob. Lub teb chaws twg tuaj - Fabkis. Koj tuaj yeem yuav cov tshuaj tsuas yog los ntawm cov tshuaj noj.

Kev ntsuas rau siv

Txhawb cov roj cholesterol ntawm thawj thiab theem ob raws li Fredrickson yog qhov tseem ceeb rau kev teem caij Lipantil. Nrog rau cov tshuaj hyperlipidemia, nws pom zoo kom suav cov Lipantil ntsiav tshuaj hauv txoj kev kho mob. Siab triglycerides kuj yuav tsum tau fenofibrate. Mob atherosclerosis ua rau muaj kev pheej hmoo ntawm myocardial infarction thiab tus cwj nrag. Hauv qhov no, rau kev tiv thaiv, cov kws kho mob pom zoo Lipantil.

Nrog intolerance mus rau lwm yam tshuaj hypolipidemic, piv txwv li, statins, kev siv ntawm fenofibrate raws li lwm txoj hauv kev tau qhia.

Sab sij huam

Feem ntau, cov neeg mob yws ntawm lub plab zom mov. Qee zaum mob leeg tuaj yeem tshwm sim, hauv qhov xwm txheej phem tshaj plaws, kev rhuav tshem cov leeg. Cov tshuaj tiv thaiv kev ua kom lub cev tsis haum rau Lipantil kuj tseem muaj. Yuav muaj pob khaus thiab khaus. Zoo li feem ntau cov lipid-txo cov tshuaj, fenofibrate nce qib ntawm daim siab enzymes hauv cov ntshav. Tom qab qhov kawg ntawm qhov kawg ntawm kev kho, kev phiv feem ntau ploj yam tsis muaj kab.

Muaj qee zaus ntawm kev siv ntau tshaj ntawm kev haus dej ntau dhau, kev kho mob raws kev ua haujlwm.

Tsuas tshuaj thiab tswj hwm

Qhov zoo tshaj koob tshuaj yuav tsuas yog xaiv los ntawm koj tus kws kho mob, noj rau hauv koj tus kheej li keeb kwm kev kho mob. Tus qauv muab tshuaj yog 200 mg ntawm cov tshuaj ib hnub. Ntawm kev txiav txim siab ntawm tus kws kho mob, qee zaum koob tshuaj txhua hnub tuaj yeem faib ua peb koob. Cov tshuaj ntsiav tau noj nrog zaub mov, ntxuav nrog dej. Hauv cov kab mob loj, kev xav tau tshuaj txhua hnub tuaj yeem ncav cuag 400 mg. Hauv qhov xwm txheej no, tus neeg mob tau mob siab rau kev tswj hwm ntawm cov neeg kho mob.

Daim ntawv thov nta

Tsis txhob siv cov khoom lag luam tshuaj rau malabsorption ntawm qabzib, galactose. Thaum sau tshuaj rau kev tso dag ntxiv ntawm fibroic acid, nws yog ib qho tsim nyog los ua kom soj ntsuam daim siab hloov ntshav siab. Qhov tso ntshav coagulation yam tseem ceeb rau kev soj ntsuam tas mus li. Nyob rau hauv tsis muaj cov ntaub ntawv tuaj yeem fibrates thiab haus dej cawv ua ke. Xws li kev sib xyaw ua ke muaj peev xwm ua rau lub siab ua rau lub siab mob hlwb, hauv qhov xwm txheej tsis zoo, nrog rau qhov tshwm sim uas tsis hloov.

Thaum cev xeeb tub thiab lactation

Lub sijhawm ntawm cev xeeb tub tsis suav nrog kev siv tshuaj kho ntxiv. Qhov tseeb, xws li pub mis niam. Txij thaum dhau los ntawm niam mis, cov tshuaj yuav cuam tshuam rau tus menyuam mos.

Tsis muaj cov ntaub ntawv tshawb fawb txog ntawm cov npe tshuaj ntawm cov menyuam yaus lub cev. Hauv qhov no, nws yog contraindicated rau hauv menyuam yaus.

Tus nqi tshuaj

Fenofibrate, lub npe lag luam Lipantil 200 M, hauv Ukraine tuaj yeem yuav thaum tus nqi kwv yees li 520 UAH rau 30 ntsiav tshuaj. Hauv khw muag tshuaj ntawm Lavxias Federation, cov tshuaj yuav ua rau koj tus nqi nruab nrab ntawm 920 rubles rau pob khoom zoo sib xws. Tsis txhob hnov ​​qab qhia koj tus kws muag tshuaj txog tshuaj los ntawm kws kho mob ua ntej yuav khoom. Nco ntsoov soj ntsuam seb cov tshuaj puas tau tas sij hawm.

Analogs Lipantil

Yog tias qhov ntau npaum ntawm Lipantil ntau dhau lawm rau tus neeg mob, hloov nrog cov ntsiab lus hauv qab fibrate muaj nyob. Piv txwv, Tricor, uas tsim tawm hauv ib koob li 145 mg hauv ib ntsiav tshuaj ntawm tib tsob nroj nrog Lipantil. Kev siv nyiaj txiag ntau dua suav nrog Fenofibrat Canon, tsim Lavxias, thiab Exlip, Qaib Cov Txwv. Tsuas yog koj tus kws kho mob yuav pab kom thaum kawg nkag siab txog ntau yam ntawm cov tshuaj pharmacological tawm tsam cov cholesterol. Tsis txhob coj cov ntaub ntawv hauv Is Taws Nem nkaus xwb.

Kev Siv Tshuaj Xyuas

Cov lus ceeb toom los ntawm kws kho mob txog kev noj tshuaj yog qhov tseeb heev - pom qhov tshwm sim zoo. Hauv thawj lub hlis ntawm kev kho, nws yog qhov ua tau los soj ntsuam thawj qhov tshwm sim thiab, yog tias tsim nyog, kho qhov koob tshuaj. Lipantil tuaj yeem siv los ua kev kho mob, lossis ua ke nrog lwm tus kws tshuaj.

Cov neeg mob txhawj xeeb tshaj plaws txog cov nyhuv ntawm cov tshuaj ntawm daim siab. Tab sis ib qho kev txo qis hauv cov roj (cholesterol) tag nrho ua rau kom muaj kev phiv. Cov neeg feem coob nco ntsoov tias qhov tsis zoo ntawm kev noj tshuaj tuaj yeem tswj tau thiab tshem tawm. Thiab tau kawg, tus nqi tsis haum rau txhua tus neeg. Txawm li cas los xij, ntau tus neeg pom zoo tias cov khoom zoo thiab cov ntawv tso cai muaj txiaj ntsig rau cov nqi.

Dosage daim ntawv

Ib qho tshuaj ntsiav muaj

cov tshuaj nquag - micronized fenofibrate 200 mg,

tus neeg excipients: lactose, sodium lauryl sulfate, pregelatinized hmoov txhuv nplej siab, crospovidone, magnesium stearate,

tshuaj ntsiav plhaub: titanium dioxide (E 171), Hlau (III) oxide daj E172, Hlau (III) oxide liab E172, gelatin.

Opaque tsiav tshuaj lub teeb xim av No. 1. Cov ntsiab lus ntawm cov tsiav tshuaj yog hmoov dawb lossis yuav luag hmoov dawb

Kev siv ntau dhau thiab kev sib txuam yeeb tshuaj

Hauv kev xyaum ua haujlwm, xws li kab mob pathological tsis tshua muaj tshwm sim. Kev noj tshuaj ntau dhau ntawm Lipantil yog qhia txog kev tsaug zog, tsis meej pem, kiv taub hau, plab zom mov. Gastric lavage yog qhov yuav tsum tau ua, ua raws li kev nqus ntawm ib qho enterosorbent - qhib cov pa roj carbon, Smecta, Enterosgel. Nws yog ib qho tsim nyog yuav tsum tau nrhiav kev pab tam sim rau kev tshem tawm kev mob thiab kev kho mob.

Cov nyhuv hypoglycemic ntawm cov tshuaj nrog sulfonylurea derivatives yog nce siab nrog lawv cov kev sib txig nrog Lipantil. Nws kuj tseem nce cov txiaj ntsig kho kom zoo ntawm kev sib piv ncaj ncaj, uas tsis yog qhov xav tau tas mus li. Kev sib xyaw ua ke ntawm cyclosporine thiab lipid-txo qis tus neeg sawv cev tuaj yeem ua rau txo qis rau hauv kev ua haujlwm ntawm cov kab mob ntawm lub tso zis, feem ntau yog lub raum.

Kev sib xyaw ua ke hauv kev kho mob ntawm Lipantil nrog rau ib qho yeeb tshuaj los ntawm pawg statin yog ua tau yog tias tus neeg mob hnyav sib xyaw ua ke nrog cov ntshav siab tsis zoo, hauv qhov tsis muaj keeb kwm mob leeg. Txoj kev kho yog tsim nyog los ntawm kev saib xyuas kev kho mob ceev faj los taw qhia cov cim ntawm kev puas tsuaj rau cov leeg pob txha.

Kev ntsuas thiab tus nqi

Cov kws kho plawv tawm tshuaj Lipantil analogues nrog ib tus neeg tsis kam mus rau nws cov khoom xyaw. Kev hloov pauv kuj tau ua nrog kev ua haujlwm qis ntawm nws qhov kev siv rau ntau lub hlis, kev txo qis tsis txaus ntawm cov qib triglycerides thiab cov lipoproteins tsawg tsawg hauv cov kab ke hauv lub cev.

Kev ua ntawm kev siv cov tshuaj uas muaj peev xwm ntau dua los ua kom cov roj (cholesterol) seem ploj thiab tshem tawm hauv lub cev. Ntawm cov txheej txheem qauv sib piv ntawm Lipantil, Fenofibrate yog feem ntau tau kho. Clofibrate thiab gemfibrozil muaj cov kev ua haujlwm zoo sib xws.

Tus nqi ntawm Lipantil nws txawv me ntsis hauv ntau thaj tsam ntawm lub teb chaws. Hauv nroog Moscow, ib pob ntawm cov ntsiav tshuaj No. 30 hauv ib koob tshuaj 200 mg tuaj yeem muab yuav rau 780 rubles. Hauv Nizhny Novgorod nws raug nqi 800 rubles, thiab hauv Volgograd nws tus nqi yog 820 rubles.

Kev txiav txim siab xaiv cov tshuaj muaj txiaj ntsig zoo thiab muaj txiaj ntsig zoo los txo qis ntawm triglycerides hauv cov hlab ntshav tau yooj yim heev. Ntawm kev kho mob thiab chaw muag tshuaj muaj ntau cov kev txheeb xyuas zoo txog Lipantil. Cov neeg kho plawv kho mob hais tias cov tshuaj tshem tawm tag nrho cov cim ntawm hyperlipidemia li ntawm 2-3 lub hlis. Lawv hais txog kev nyab xeeb tshuaj, qhov tsis tshua pom muaj tshwm sim hauv cheeb tsam thiab lub cev.

Maria Dmitrievna, 64 xyoo, Ryazan: Kuv qib roj cholesterol pib nce txij li 50 xyoo. Thaum xub thawj, tsis muaj cov tsos mob, tab sis tom qab ntawd nws kev noj qab haus huv tsis zoo. Kuv lub taub hau pib zoo li kiv taub hau, txog siav ua pa txawm tias taug kev luv luv. Tus kws kho plawv tawm tswv yim kom noj Lipantil tshuaj ntsiav rau peb lub hlis. Kev noj qab haus huv tau pib zoo nyob hauv kwv yees li ib hlis.

Nikolay, 49 xyoo, Zheleznovodsk: Kuv muaj ib qho keeb kwm kab mob kev txhim kho ntawm cov hlab plawv plawv. Yog li, tus kws kho plawv tau txais kev kho mob tam sim ntawd tom qab kuaj pom tias nce qib ntau ntawm triglycerides. Thaum xub thawj kuv tau noj tshuaj los ntawm pawg statin, tab sis cov txiaj ntsig tsis zoo tshaj qhov kev cia siab. Tus kws kho mob pom zoo kom noj Lipantil ntawm koob tshuaj 200 mg. Peb lub hlis tom qab, cov ntaub ntawv biochemical tau zoo heev.

Cov chaw muag tshuaj

Xuas. Tom qab qhov ncauj tswj hwm ntawm Lipantil 200M Cmax capsule (qhov siab tshaj plaws) ntawm fenofibroic acid tau tiav tom qab 4-5 teev. Nrog rau siv ntev, kev saib xyuas ntawm fenofibroic acid hauv cov ntshav tseem nyob ruaj khov, tsis hais tus yam ntxwv ntawm tus neeg mob. Cmax hauv cov ntshav ntshav thiab tag nrho cov txiaj ntsig ntawm micronized fenofibrate nce nrog kev noj zaub mov.

Fenofibroic acid yog khov kho thiab ntau dua 99% ua txhua yam rau cov plasma albumin.

Kev ntsuas phoo thiab nthuav tawm

Tom qab kev tswj hwm ntawm qhov ncauj, fenofibrate tau nrawm nrawm los ntawm esterases mus rau fenofibroic acid, uas yog nws cov ntsiab lus nquag metabolite. Fenofibrate tsis pom nyob hauv cov ntshav. Fenofibrate tsis yog lub cev rau CYP3A4, tsis koom nrog microsomal metabolism hauv lub siab.

Fenofibrate tsuas yog tawm hauv cov zis hauv daim ntawv ntawm fenofibroic acid thiab glucuronide conjugate. Tsis pub dhau 6 hnub, fenofibrate yog tas yuav luag txhua yam. Hauv cov neeg mob laus, tag nrho kev tshem tawm ntawm fenofibroic acid tsis hloov. Ib nrab-lub neej ntawm fenofibroic acid (T1 / 2) yog kwv yees li 20 teev. Thaum hemodialysis tsis tshwm. Kev tshawb nrhiav qhov tseem ceeb tau pom tias fenofibrate tsis nthuav dav tom qab ib koob thiab nrog siv ntev.

Tus neeg sawv cev hypolipidemic los ntawm pab pawg ntawm derivatives ntawm fibroic acid.Fenofibrate muaj peev xwm hloov lipid cov ntsiab lus hauv tib neeg lub cev los ntawm kev ua kom ntawm PPAR-α receptors (alpha receptors ua haujlwm los ntawm peroxisome proliferator).

Fenofibrate ua rau plasma lipolysis thiab kev nthuav dav ntawm atherogenic lipoproteins nrog cov ntsiab lus ntawm triglycerides los ntawm kev ua kom cov tshuaj PPAR-α cov neeg txais, lipoprotein lipase thiab txo cov synthesis ntawm apoprotein C-III (apo C-III). Cov teebmeem uas tau piav qhia saum toj no ua rau txo qis ntawm feem ntau ntawm lipoprotein (HDL) tsawg, uas suav nrog apoprotein B (apo B), thiab qhov nce ntawm feem ntau ntawm lipoprotein tsawg (HDL), uas suav nrog apoprotein A-I ( apo A-I) thiab apoprotein A-II (apo A-II). Ntxiv rau, vim kev txhim kho ntawm kev sib txuas thiab catabolism teeb meem ntawm VLDL, fenofibrate tsub kom qhov kev tshem ntawm LDL thiab txo cov ntsiab lus ntawm cov me me thiab ntom ntawm LDL (kev nce hauv cov LDL raug pom nyob hauv cov neeg mob uas muaj atherogenic lipid phenotype thiab cuam tshuam nrog kev pheej hmoo ntawm cov ntshav plawv-IHD).

Hauv cov kev tshawb fawb soj ntsuam, nws tau sau tseg tias kev siv cov fenofibrate txo qib ntawm cov roj (Ch) txhua 20-25% thiab triglycerides los ntawm 40-55% nrog qhov nce ntawm qib HDL-C los ntawm 10-30%. Hauv cov neeg mob hypercholesterolemia, uas qib Chs-LDL raug txo qis 20-35%, kev siv cov fenofibrate ua rau txo qis hauv feem ntau: tag nrho Chs / Chs-HDL, Chs-LDL / Chs-HDL thiab apo B / apo A-I, uas yog cov cim ntawm atherogenic kev pheej hmoo.

Xav txog cov txiaj ntsig ntawm fenofibrate nyob rau theem ntawm LDL-C thiab triglycerides, kev siv cov tshuaj muaj txiaj ntsig ntawm cov neeg mob hypercholesterolemia, ob leeg nrog thiab tsis nrog hypertriglyceridemia, suav nrog hyperlipoproteinemia theem nrab, piv txwv li, nrog hom 2 ntshav qab zib mellitus.

Muaj pov thawj qhia tias cov fibrates tuaj yeem txo qis kev mob plawv mob plawv, tab sis tsis muaj ib qho pov thawj ntawm qhov txo qis hauv kev tuag tag nrho hauv thawj lossis kev tiv thaiv kab mob plawv.

Thaum kho nrog fenofibrate, kev tso nyiaj ntxiv ntawm XC (leeg thiab tubant xanthomas) tuaj yeem txo qis thiab txawm ploj tag. Hauv cov neeg mob uas muaj cov ntshav siab fibrinogen uas tau txais kev kho fenofibrate, qhov kev txo qis tseem ceeb hauv qhov ntsuas no tau sau tseg, zoo li hauv cov neeg mob uas muaj lipoprotein ntau ntau. Hauv kev kho mob ntawm fenofibrate, ib qho kev txo qis ntawm kev saib xyuas ntawm C-reactive protein thiab lwm cov cim ntawm kev mob tshwm sim.

Rau cov neeg mob dyslipidemia thiab hyperuricemia, ib qho ntxiv kom zoo dua yog tias fenofibrate muaj cov nyhuv uricosuric, uas ua rau txo qis hauv cov concentration ntawm uric acid los ntawm kwv yees li 25%.

Hauv cov kev tshawb fawb soj ntsuam thiab hauv kev sim tsiaj, fenofibrate tau pom tias txo cov platelet sib xyaw los ntawm adenosine diphosphate, arachidonic acid, thiab epinephrine.

Cov tshuaj sib cuam tshuam

Cov tshuaj tiv thaiv qhov ncauj tsis pom zoo rau tib lub sijhawm Lipantil 200M. Fenofibrate ua rau cov nyhuv ntawm cov tshuaj tiv thaiv qhov ncauj thiab yuav ua rau muaj kev pheej hmoo los ntshav. Thaum pib ntawm kev kho mob nrog fenofibrate, nws raug nquahu kom txo qis cov tshuaj anticoagulants los ntawm ib feem peb, tom qab los ntawm kev xaiv maj mam ntawm koob tshuaj. Kev xaiv koob yog pom zoo kom ua tiav nyob rau hauv kev tswj hwm ntawm theem ntawm MHO (thoob ntiaj teb li qub sib piv).

Cyclosporin. Ntau qhov xwm txheej ntawm kev thim rov qab uas tau txo qis hauv kev ua haujlwm thaum lub sijhawm sim kho nrog fenofibrate thiab cyclosporine tau piav qhia. Yog li, nws yog qhov yuav tsum tau soj ntsuam lub xeev ntawm lub raum kev ua haujlwm hauv cov neeg mob zoo li no thiab tshem tawm Lipantil 200M thaum muaj kev hloov pauv hauv chav ntsuas tsis tau.

Co-A reductase inhibitors thiab lwm yam khoom fibrates. Thaum noj fenofibrate tib lub sijhawm uas HMG-CoA reductase inhibitors lossis lwm cov fibrates, qhov kev pheej hmoo ntawm kev phiv los ntawm cov leeg nqaij ua kom muaj zog. Nws yog ib qho tsim nyog yuav tsum siv cov tshuaj ntawm pab pawg no nrog Lipantil 200M nrog kev ceev faj, cov neeg mob yuav tsum ua tib zoo saib kom pom cov cim ntawm cov leeg lom

Glitazones. Muaj cov ntawv tshaj tawm txog kev tsis sib haum xeeb ntawm qhov rov qab txo qis hauv HDL cov roj (cholesterol) thaum noj fenofibrate ua ke nrog cov tshuaj los ntawm cov pawg glitazone. Yog li, nws raug nquahu kom soj ntsuam cov qib roj HDL nrog cov kev siv tshuaj lossis kev tshem tawm ib qho ntawm lawv, nrog cov roj HDL muaj roj tsawg.

Cytochrome P450 Enzymes. Hauv kev tshawb nrhiav hauv vitro ntawm tib neeg lub siab microsomes tau pom tias fenofibrate thiab fenofibroic acid tsis yog cov tshuaj tiv thaiv ntawm isoenzymes CYP3A4, CYP2D6, CYP2E1 lossis CYP1A2. Hauv kev siv tshuaj ntau ntau, cov tebchaw no yog cov tsis muaj zog ntawm CYP2C19 thiab CYP2A6 isoenzymes thiab cov tsis muaj zog lossis tsis tshua mob hnyav ntawm CYP2C9.

Cov neeg mob noj tshuaj nrog cov ntawv nqaim kho ua ke nrog fenofibrate, hauv cov metabolism hauv cov enzymes CYP2C19, CYP2A6 thiab, tshwj xeeb, CYP2C9 muaj kev koom tes, xav tau kev saib xyuas kom zoo. Yog tias tsim nyog, yuav tsum tau txhaj koob tshuaj ntawm cov tshuaj no.