Melfor (Melfor)

Vim tias qhov tshwm sim tsim tau cov txiaj ntsig zoo, tshuaj pom zoo tshuaj ntsiav. TSWV NTUJ thaum sawv ntxov. Qhov koob tshuaj tau teeb tsa ib tus zuj zus nyob ntawm qhov ntsuas thiab txoj kev ntawm kev tswj hwm.
Thaum noj ntawm qhov ncauj, ib koob tshuaj yog 0.25-1 g, qhov ntau zaus ntawm kev coj ua thiab lub sijhawm ntawm kev kho mob yog nyob ntawm qhov ntsuas.
Nrog kev tswj hwm iv, qhov koob tshuaj yog 0.5-1 g 1 zaug / hnub, sijhawm kho yog nyob ntawm cov ntsuas.
0.5 ml ntawm kev txhaj tshuaj nrog cov tshuaj 500 mg / 5 ml tau muab tshuaj parabulbarly rau 10 hnub.

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv kom zoo rau kev siv tshuaj TSWV NTUJ yog: nce siab intracranial (suav nrog qee qhov ua rau lub cev ntuag ntshav tawm, mob qog ua rau lub plab), cev xeeb tub, lactation (pub mis niam), menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo, nce siab zoo rau meldonium.

Kev cuam tshuam nrog lwm yam tshuaj

Thaum ua ke, meldonium txhim kho kev txiav txim siab ntawm cov tshuaj antianginal, qee cov tshuaj tiv thaiv kabmob ntshav, mob glycosides.
Nrog rau kev siv tib lub sijhawm ntawm meldonium nrog nitroglycerin, nifedipine, alpha-blockers, antihypertensive tus neeg sawv cev thiab peripheral vasodilators, tachycardia muaj ntsis, mob hypotension tuaj yeem tsim (nrog cov kev sib txuas ua ke no, yuav tsum ceev faj).

Kev ntsuas rau siv

- Txo qis kev ua haujlwm, nce lub cev, lub sijhawm tom qab sijhawm txhawm rau txhawm rau txhim kho kom rov zoo.

- Raws li ib feem ntawm txoj kev kho mob ntsig txog kev mob plawv mob ntshav plawv, mob plawv tsis xwm yeem, cardialgia tiv thaiv keeb kwm ntawm dishormonal myocardial dystrophy.

- Raws li ib feem ntawm cov kev kho mob nyuaj rau cov kev xoom xoos ntawm cerebrovascular (kev mob qog nqaij hlav ntawm cov ntshav ischemic, tshwj xeeb tshaj yog cov mob sib kis, cov kab mob cerebrovascular tsis txaus).

- Txoj kev kho mob nyuaj siab ntawm kev tshem tawm cov cawv cawv.

- Mob puas hlwb ncig, hemophthalmus thiab retinal hemorrhages ntawm ntau yam etiologies, mob txha caj qaum mob hlab ntsha leeg thiab nws cov ceg, retinopathy ntawm ntau etiologies (suav nrog kev mob ntshav qab zib thiab kub siab).

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Kev daws rau kev txhaj tshuaj

Nce kev nyuaj siab mob hlwb thiab lub cev: mob siab rau ntawm 500 mg (5 ml) ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-14 hnub. Yog tias tsim nyog, chav kawm raug rov ua dua tom qab 2-3 lub lis piam. Rau cov kab mob plawv (ua ib feem ntawm cov kev kho mob nyuaj): cia 500-1000 mg (5-10 ml). Lub chav kawm ntawm kev kho mob yog 10-14 hnub.

Ischemic cerebrovascular kev sib tsoo, tshwj xeeb tshaj yog cov kev sib raug mob theem (ib feem ntawm kev sib xyaw ua ke): 500 mg txhaj tshuaj (5 ml) 1 zaug hauv ib hnub rau 7-10 hnub, tom qab ntawd lawv hloov mus rau kev tswj hwm qhov ncauj.

Cov kab mob cerebrovascular tsis txaus noj tshuaj: 500 mg intramuscularly (5 ml) ib hnub ib zaug. Lub chav kawm ntawm kev kho mob yog 10-14 hnub, tom qab ntawd lawv hloov mus rau kev tswj hwm qhov ncauj. Kev haus cawv haus cawv: tso dej - 500 mg (5 ml) 2 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 7-10 hnub.

Vascular pathology ntawm pob nyiaj thiab rov ua haujlwm pob txha: 50 mg (0.5 ml) cov tshuaj txhaj yog muab rov qab retrobulbarly thiab subconjunctively rau 10 hnub.

Nws yog noj ntawm qhov ncauj, ua ntej noj mov, vim tias qhov zoo txaus siab nws raug nquahu kom siv nws thaum sawv ntxov.

Kev ua kom lub cev ntau ntxiv 250 mg 4 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 10-14 hnub. Yog tias tsim nyog, txoj kev kho mob tau rov ua dua tom qab 2-3 lub lis piam. Cov kis las tau sau tseg rau 500-1000 mg 2 zaug ib hnub ua ntej kev cob qhia. Lub sijhawm ntawm kev kawm hauv lub sijhawm npaj yog 14-21 hnub, lub sijhawm sib tw - 10-14 hnub.

Nrog rau cov kab mob plawv (ua ib feem ntawm txoj kev kho mob nyuaj):

Ruaj khov angina pectoris - 250 mg 3 zaug ib hnub twg rau 3-4 hnub, tom qab ntawd 250 mg 3 zaug ib hnub 2 zaug hauv ib lub lis piam rau 1-1.5 lub hlis.

Myocardial infarction: nyob rau lub sijhawm mob - sib zog, tom qab ntawd sab hauv los ntawm 500 mg rau ib hnub, siv tag nrho cov koob tshuaj ib zaug lossis 2 zaug hauv ib hnub.

Mob plawv nres - 500-1000 mg ib hnub ib zaug. Lub sij hawm ntawm kev kho mob yog 4-6 lub lis piam.

Cardialgia rau ntawm keeb kwm ntawm dishormonal myocardial dystrophy 250 mg 2 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 12 hnub.

Cerebrovascular kev huam yuaj: hauv lub sijhawm mob sai sai, ceev, tom qab ntawd 500 mg rau ib hnub, nyiam dua hauv thawj ib nrab ntawm ib hnub. Lub sij hawm ntawm kev kho mob yog 4-6 lub lis piam.

Kev tshem tawm cov cawv cawv (ua ib feem ntawm kev sib xyaw tshwj xeeb) 500 mg 4 zaug hauv ib hnub. Lub chav kawm ntawm kev kho mob yog 7-10 hnub.

Pharmacological kev txiav txim

Cov tshuaj nquag ntawm Melfora yog meldonium - ib qho hluavtaws sib piv ntawm gamma-butyrobetaine, uas txwv qhov kev txiav txim ntawm gamma-butyrobetaine hydroxynase. Hauv cov xwm txheej ntawm ischemia, nws rov qab kho qhov sib npaug ntawm cov txheej txheem ntawm cov pa oxygen thiab nws kev noj nyob hauv hlwb. Tus txheej txheem ntawm kev txiav txim siab txiav txim siab ntau haiv neeg ntawm nws cov txiaj ntsig pharmacological: nce kev ua tau zoo, txo qis cov tsos mob ntawm lub siab thiab lub cev, ua kom cov nqaij mos thiab lub cev tsis muaj kev tiv thaiv.

Nws muaj cov teebmeem cardioprotective: thaum muaj mob ischemic tsis zoo rau lub myocardium, txo qis qhov tsim ntawm thaj chaw necrotic, ua kom lub sijhawm rov ua kom sai. Nrog rau lub plawv tsis ua haujlwm, nws nce myocardial contractility, nce kev qoj ib ce zam, thiab txo qis zaus ntawm kev mob taub hau. Hauv kev mob siab thiab mob ntsws ischemic mob hlwb cerebral ncig txhim kho cov ntshav ncig hauv kev ua kom pom tseeb ntawm ischemia, pab txhawb txoj kev rov faib cov ntshav hauv kev pom zoo ntawm thaj chaw ischemic. Pib thaum vascular thiab dystrophic fundus pathology. Nws muaj cov nyhuv tonic rau lub hauv nruab nrab lub paj hlwb thiab tshem tawm cov kev ua haujlwm tsis haum xeeb ntawm somatic thiab autonomic lub paj hlwb hauv cov neeg mob uas muaj cawv ntev nrog kev tshem tawm mob.

Sab sij huam

Kev tsis haum tshuaj (liab, ua pob rau ntawm daim tawv nqaij, khaus, tawm pob), dyspepsia, tachycardia, txo qis lossis nce ntshav siab, ntxhov siab yog qhov tsis tshua muaj.

Nrog kev noj tshuaj ntau dhau ntawm Melfort, qhov txo qis hauv ntshav siab, mob taub hau, tachycardia, kiv taub hau, kev ua kom tsis muaj zog. Txoj kev kho yog mob.

Tso tawm daim ntawv, ntim thiab muaj pes tsawg leeg

5 pcs. - blister packs (1) - pob ntawv los ntawm cardboard.
5 pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.
5 pcs. - blister packs (3) - pob ntawv ntawm cardboard.
5 pcs. - hlwv pob (4) - pob khoom los ntawm cardboard.
5 pcs. - blister packagings (6) - pob ntawv ntawm cardboard.
5 pcs. - blister pob khoom (10) - pob ntawv ntawm cardboard.
10 Pcs. - blister packs (1) - pob ntawv los ntawm cardboard.
10 Pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.
10 Pcs. - blister packs (3) - pob ntawv ntawm cardboard.
10 Pcs. - hlwv pob (4) - pob khoom los ntawm cardboard.
10 Pcs. - blister packagings (6) - pob ntawv ntawm cardboard.
10 Pcs. - blister pob khoom (10) - pob ntawv ntawm cardboard.
30 pcs - blister packs (1) - pob ntawv los ntawm cardboard.
30 pcs - blister packagings (2) - pob ntawv los ntawm cardboard.
30 pcs - blister packs (3) - pob ntawv ntawm cardboard.
30 pcs - hlwv pob (4) - pob khoom los ntawm cardboard.
30 pcs - blister packagings (6) - pob ntawv ntawm cardboard.
30 pcs - blister pob khoom (10) - pob ntawv ntawm cardboard.
10 Pcs. - polymer ntim (1) - pob khoom los ntawm cardboard.
20 Pcs. - polymer ntim (1) - pob khoom los ntawm cardboard.
30 pcs - polymer ntim (1) - pob khoom los ntawm cardboard.
40 pcs. - polymer ntim (1) - pob khoom los ntawm cardboard.
50 pcs. - polymer ntim (1) - pob khoom los ntawm cardboard.
100 pcs - polymer ntim (1) - pob khoom los ntawm cardboard.

Tshuaj los qhia

Rau qhov ncauj lossis tso ntshav kev tswj hwm: raws li ib feem ntawm txoj kev kho mob ntawm txoj hlab ntshav plawv (angina pectoris, myocardial infarction), mob plawv tsis ua hauj lwm, lub plawv tsis ua haujlwm, ua rau lub plawv tsis ua haujlwm, ua ib feem ntawm txoj kev kho mob ntawm tus mob thiab cov kab mob cerebrovascular mob hlwb (mob ntshav tawm hws thiab cerebrovascular tsis txaus), txo qis kev ua haujlwm, lub cev dhau los. (suav nrog cov neeg ncaws pob), lub sijhawm tom qab tau nrawm kom nrawm rov ua dua tshiab, thim rov qab cov tsos mob hauv kev haus dej cawv ntev (nrog rau kev kho mob tshwj xeeb, haus dej cawv ZMA).

Rau kev tswj hwm parabulbar: kev mob siab rau hauv retina, hemophthalmus thiab cov leeg ntshav ntawm ntau cov vev xaib, mob ntshav ntawm txoj leeg ntshav ntawm cov leeg ntshav thiab nws cov ceg, retinopathy ntawm ntau etiologies (suav nrog rau cov ntshav qab zib thiab hypertonic) - tsuas yog rau cov kev tswj hwm parabulbar.

Kev noj tshuaj ntxiv

Hauv kev sib txuas nrog qhov ua tau los txhim kho qhov ua tau zoo, nws raug nquahu kom siv nws thaum sawv ntxov. Qhov koob tshuaj tau teeb tsa ib tus zuj zus nyob ntawm qhov ntsuas thiab txoj kev ntawm kev tswj hwm.

Thaum noj ntawm qhov ncauj, ib koob tshuaj yog 0.25-1 g, qhov ntau zaus ntawm kev coj ua thiab lub sijhawm ntawm kev kho mob yog nyob ntawm qhov ntsuas.

Nrog kev tswj hwm iv, qhov koob tshuaj yog 0.5-1 g 1 zaug / hnub, sijhawm kho yog nyob ntawm cov ntsuas.

0.5 ml ntawm kev txhaj tshuaj nrog cov tshuaj 500 mg / 5 ml tau muab tshuaj parabulbarly rau 10 hnub.

Cov lus qhia tshwj xeeb

Siv nrog ceev faj hauv cov kab mob ntawm daim siab thiab / lossis raum, tshwj xeeb yog siv sijhawm ntev.

Ntau xyoo ntawm cov kev paub hauv kev kho mob ntawm tus mob myocardial infarction thiab tsis txaus ntseeg lub siab hauv lub plawv kev kho mob qhia tias meldonium tsis yog thawj txoj kev kho mob rau txoj kev mob caj dab.

Yeeb tshuaj sib cuam tshuam

Thaum ua ke, meldonium txhim kho kev txiav txim siab ntawm cov tshuaj antianginal, qee cov tshuaj tiv thaiv kabmob ntshav, mob glycosides.

Nrog rau kev siv tib lub sijhawm ntawm meldonium nrog nitroglycerin, nifedipine, alpha-blockers, antihypertensive tus neeg sawv cev thiab peripheral vasodilators, tachycardia muaj ntsis, mob hypotension tuaj yeem tsim (nrog cov kev sib txuas ua ke no, yuav tsum ceev faj).

Mechanism ntawm kev ua

Cov tshuaj yog ib qho tshuaj noj sib npaug ntawm γ-butyrobetaine. Nws muaj qhov ua tau zoo dhau ntawm kev ua kom muaj cov carnitine thiab kev txav ntawm cov roj acids los ntawm cov xovtooj ntawm tes, thiab tiv thaiv kev tsub zuj zuj ntawm derivatives ntawm acetyl coenzyme thiab acyl carnitine hauv hlwb.

Pharmacodynamics ntawm cov tshuaj cuam tshuam nrog kev nce qib hauv qib.

Hauv kev kho ischemia, cov tshuaj normalizes thauj / noj ntawm oxygen los ntawm cov hlwb, tiv thaiv kev txav ntawm ATP thiab ua kom glycolysis. Los ntawm kev txo theem ntawm cov carnitine, cov tshuaj txhim kho cov kev ncig ntawm gamma-butyrobetaine, uas muaj cov nyhuv vasodilating. Pharmacodynamics ntawm cov tshuaj cuam tshuam nrog kev nce qib hauv kev ua haujlwm, txo qis cov tshwm sim ntawm lub cev / lub hlwb kev nyuaj siab, thiab txhim kho kev tiv thaiv kev tu cev / nqaij mos.

Hauv cov qauv mob ntawm ischemia, cov tshuaj inhibits myocardial contractility thiab cov txheej txheem necrotic, ntxiv rau kev ua kom sai. Tsis tas li ntawd, ua suab nrov ntawm lub hauv nruab nrab lub paj hlwb thiab qhov haujlwm nws ua haujlwm hauv kev tshem tawm cov cawv.

Cov tshuaj yog nqus los ntawm cov hnyuv. Nws qhov kev siv xyoob ntoo mus txog 78%.

Qhov siab tshaj plaws tom qab kev tswj hwm ntawm qhov ncauj yog pom tom qab 60-120 feeb.

Thaum lub sij hawm biotransformation, cov tshuaj tsim ib khub ntawm metabolites nyob rau hauv lub cev. Kev tshem tawm ib nrab-lub neej yog los ntawm 3 txog 6 teev. Cov tshuaj siv tawm hauv raum.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Ntawm kev muag, cov tshuaj tau muaj hauv cov qauv hauv cov tshuaj ntsiav thiab cov tshuaj tov.

Muaj 1 lub tshuaj:

• lub caij nquag (meldonium dihydrate) - 500 mg,
• lwm cov khoom siv: 27.2 mg ntawm cov hmoov txhuv nplej siab, 10.8 mg ntawm colloidal silicon dioxide, 5.4 mg ntawm calcium stearate,
• lub hau thiab tshuaj ntsiav lub cev yog 98% nkaws thiab 2% titanium dioxide.

Sab hauv cov tsiav tshuaj yog hmoov dawb hygroscopic.

Ntawm kev muag, cov tshuaj tau muaj hauv cov qauv ntawm cov tshuaj ntsiav.

Cov tshuaj yog muab tso rau hauv 5 ml ampoules, uas yog nyob rau hauv cov contour ntawm pob ntawv thiab cov thawv ntawv thawv.

Sab sij huam

Hauv qab no kev tawm tsam ntawm cov tshuaj yog muaj peev xwm:

• ua xua: o, tawm pob, liab liab (muaj tsawg),
• Lub plab zom mov: ua kom lub plab zom mov,
• CNS: kev txhawb ntawm kev xav ntawm psychomotor,
• CVS: nce / txo qis hauv cov ntshav siab, tachycardia (feem ntau tsis tshua muaj neeg mob).

Tom qab siv cov tshuaj, cov pob khaus yog ua tau.

Cawv tau zoo

Kev ua haujlwm ntawm cov tshuaj yog tawm hauv thaj tsam 12 teev. Tom qab lub sijhawm no, qhov kev pheej hmoo ntawm qhov tsis zoo ntawm kev cuam tshuam ntawm cov tshuaj nrog lwm lub ntsiab lus yog qhaj ntawv lossis tsawg.

Cov lus qhia rau kev siv tshuaj tsis txwv tsis pub sib xyaw ua ke nrog cawv. Txawm li cas los xij, yog hais tias chav kawm ntawm nws txoj kev tswj hwm yog nqa tawm los kho txhua yam kab mob ntawm cov hlab plawv hlab ntsha los yog kab mob cerebrovascular, tus neeg mob yuav tsum zam kev haus cawv. Qhov no yog vim qhov kev pheej hmoo ntawm kev txo qis hauv qhov kev ua pharmacological ntawm cov tshuaj. Xws li cov zoo sib xws tuaj yeem ua rau:

• kev tsis haum,
• tachycardia thiab angina pectoris,
• dyspeptic mob
• dhia hauv ntshav siab.

Thaum noj cov tshuaj thiab dej cawv, dhia hauv ntshav siab tuaj yeem tshwm sim.

Hnub tas sij hawm

Tsis pub ntau tshaj 4 xyoos txij li hnub ntawm kev tsim khoom. Nws yog txwv tsis pub haus thiab hno tshuaj, lub hnub tas sij hawm uas tau tuaj txog qhov kawg.

Qee zaum, yog tias cov tshuaj tsis tuaj kawm ntawv lossis tsis haum vim yog contraindications, koj tuaj yeem them sai sai rau nws hloov chaw.

Qhov ua tau zoo thiab nrov tshaj plaws ntawm lawv yog:

Vim tias tsis muaj qhov tshwm sim tsis zoo thaum lub caij tswj hwm thiab kev ua haujlwm, cov tshuaj tau txais feem ntau zoo xyuas los ntawm cov kws kho mob thiab cov neeg mob. Nws koom tes rau kev ua kom muaj txiaj ntsig thiab lub zog rov qab.

Gennady Oprishchenko (tus kws kho mob), hnub nyoog 40 xyoo, Pushkino

Tag nrho ob daim ntawv ntawm cov tshuaj (tsiav tshuaj thiab daws) yog sib npaug zoo nyob rau hauv kev tshem tawm cov tsos mob, circulatory ntshawv siab nyob rau hauv GM thiab lwm yam pathologies. Cov neeg mob txaus siab rau tus nqi pheej yig ntawm cov tshuaj thiab yuav luag tiav qhov "phiv".

Ekaterina Kolpakova (kws kho mob), 36 xyoo, Yaroslavl

Kuv muab tshuaj rau hauv cov tshuaj tsis yog rau cov neeg muaj mob, tab sis kuj tseem noj qab haus huv (cov neeg ncaws pob) los txhim kho kev ua haujlwm. Nws pab tau zoo thaum lawv raug ntau lub siab thiab lub siab. Cov kev mob tshwm sim rau tag nrho lub sijhawm ntawm kuv lub sijhawm tsis ua haujlwm.

Stanislav Smirnov, 41 xyoo, Ryazan

Cov tshuaj pab kuv tij laug kom dim ntawm txoj kev haus cawv. Tus kws kho mob tau muab tshuaj nrog rau lwm cov ntsiav tshuaj. Tam sim no tus tij laug tau hauj lwm thiab ua lub neej zoo.

Inga Stepanenko, 38 xyoo, Sergiev Posad

Cov tshuaj tau qaug cawv thaum ua haujlwm tsis tiav hauv lub hlwb. Kev ua haujlwm zoo tau tshwm sim sai sai, qhov tsis muaj qhov tshwm sim tsis tuaj yeem tab sis zoo siab. Yog, thiab tus nqi sib tw tau.

Melfor cov neeg mob tshuaj xyuas

Tus kws kho mob tau sau ntawv rau kuv Melfor ua qhov pheej yig ntawm lwm cov tshuaj. Yog li nws tau thov kuv - txhawm rau nqa tshuaj pheej yig lossis kev lag luam pheej yig hauv tebchaws.Vim li cas kuv xav tau ib qho kim kim? Rau ob peb lub hlis tam sim no, nws tau sau tseg rau kuv thiab muaj qee qhov tshwm sim: nws tau ua taug kev yooj yim dua, kev tawm tsam angina tsis tshua muaj tshwm sim. Feem ntau, Kuv txaus siab txog Melfor. Ua tsaug tshwj xeeb rau cov kws kho mob uas nkag siab tias cov neeg so haujlwm tuaj yeem tsis muaj nyiaj rau cov tshuaj muaj nqi kim thiab muab cov kev xaiv rau lawv!

Cov lus qhia luv luv

Cov tshuaj tiv thaiv kab mob hauv tsev hauv cov tshuaj tiv thaiv me me yog cov tshuaj Melfor (cov tshuaj ua kom sib xyaw meldonium) - cov tshuaj uas muaj cov tshuaj metabolic uas ua rau cov ntshav pauv ntawm cov txheej txheem hauv lub cev thiab txhim kho lub zog ntawm cov nqaij. Nws txwv tsis pub nkag mus rau hauv mitochondria ntawm cov roj ua kom dawb, yog li txo qhov oxidation ntawm cov tom kawg. Melfore txwv tsis pub thauj cov roj fatty acids uas yog los ntawm cov kab mob mitochondrial, txawm li cas los xij, nws ua nyob rau hauv no hais xaiv ntau yam, tsis dhau tsuas yog cov saw ntev fatty acids. Raws li rau cov luv luv-saw sawv daws, lawv tuaj yeem nkag mus rau hauv mitochondria thiab ua txhua yam uas lawv nyiam muaj (ua ntej txhua yam, peb tab tom tham txog lawv cov oxidation). Tsis zoo li trimetazidine, Melfore tsis ua rau kom muaj tsub zuj zuj ntawm cov kab mob rog-oxidized fatty acids hauv mitochondria. Tawm tsam keeb kwm ntawm ischemia, cov tshuaj kho kom rov qab zoo qhov sib luag hauv cov txheej txheem ntawm oxygen thauj mus rau cov ntaub so ntswg thiab nws noj ntawm qhov chaw xa khoom. Nyob rau tib lub sijhawm, anaerobic glycolysis zuj zus ntxiv. Raws li kev txiav txim ntawm melphor, cov gamma-butyrobetaine vasodilator pib nquag tsim kom muaj me nyuam. Cov tshuaj txhim kho kev ua haujlwm, qee qhov txo cov tsos mob ntawm lub cev kev ua kom lub cev thiab lub siab lub ntsws dhau los, txhim kho lub cev tsis muaj zog, ua haujlwm ntawm ob lub cev thiab txo kev tiv thaiv kev tiv thaiv, thiab muaj cov nyhuv cardioprotective. Hauv kev mob ischemic ua rau cov leeg mob plawv, Melfor txo qis ntawm necrosis, nrawm kho dua. Nrog cov tsis muaj txhij ntawm kev ua haujlwm ntawm lub plawv, nws nce kev cog lus ntawm lub plawv nqaij ntshiv, txhim kho qhov kam rau ntawm kev ua haujlwm ntawm lub cev, thiab txo qhov kev pheej hmoo ntawm angina pectoris. Nrog lub hlwb ischemia, melfor txhim kho cov ntshav ncig hauv ischemic foci, coj cov ntshav ntws mus rau thaj chaw ischemic feem ntau. Ib qho tsis tuaj yeem nco ntsoov cov txiaj ntsig pom tseeb ntawm kev siv Melfor rau pathologies ntawm fundus (vascular thiab dystrophic).

Cov tshuaj kuj tseem tuaj yeem siv rau hauv kev kho mob nyuaj rau cov neeg mob kev txom nyem los ntawm kev quav dej cawv: nws ua rau lub hauv nruab nrab cov hlab ntsha thiab tshem tawm cov txiaj ntsig ntawm kev ua haujlwm ntawm nws qhov tsis zoo. Daim ntawv teev cov txiaj ntsig zoo ntawm Melfor tsis yog txwv rau qhov no: piv txwv li, cov yeeb tshuaj tso tawm cov tshuaj tiv thaiv kev tiv thaiv, tiv thaiv lipid peroxidation thiab ua kom muaj cov tshuaj tua kab mob endogenous, raws li cov txiaj ntsig ntawm oxidative kev nyuaj siab yog smoothed tawm. Hauv cov kev tshawb fawb soj ntsuam, lub peev xwm ntawm Melfor los cuam tshuam zoo rau lub luag haujlwm ntawm endothelium thiab tswj cov suab nrov ntawm cov hlab ntshav tau paub tseeb. Tsis tas li ntawd, nws tau pom tias cov tshuaj tseem muaj lwm cov kev mob vascular: piv txwv li, nws tshem tawm cov qog adrenal thiab angiotensin vascular spasms, thiab txo qis tag nrho peripheral vascular tsis kam. Tsis tas li ntawd, melfor nce qhov rhiab heev ntawm cov ntaub so ntswg mus rau insulin, tswj cov metabolism hauv lipids thiab qabzib.

Melfor muaj nyob rau hauv ob daim ntawv qhia: cov tshuaj ntsiav thiab cov tshuaj rau kev txhaj tshuaj. Nws raug nquahu kom noj cov tshuaj thaum sawv ntxov, li nws tuaj yeem txaus siab. Cov koob tshuaj yog teem los ntawm tus kws kho mob zuj zus. Raws li cov lus pom zoo dav dav rau kev tswj hwm qhov ncauj, qhov tshuaj ib zaug ntawm Melfor yog 0.25-1 g, qhov ntau zaus ntawm kev tswj hwm thiab lub sijhawm ntawm cov tshuaj raug txiav txim los ntawm kev qhia tshwj xeeb. Nrog kev tswj hwm zoo tshuaj, txhua hnub ntawm cov tshuaj yog 0.5-1 g, muab nyob rau ib lub sijhawm. Parabulbar (los ntawm daim tawv nqaij ntawm daim tawv muag qis) Melfor yog muab rau hauv 0.5 ml rau 10 hnub. Hauv kev xaus, ib qho tseem ceeb hais: raws li cov kev tshawb fawb soj ntsuam thiab kev paub txog kev kho mob tsis ruaj ntseg angina thiab mob myocardial infarction tau qhia, Melfor tsis yog qhov kev xaiv thawj zaug hauv kev mob caj dab.

Kws Tshuaj

Kev txhim kho kev zom zaub mov, gamma-butyrobetaine analogue. Nws tshem tawm gamma-butyrobetaine hydroxynase, inhibits cov synthesis ntawm carnitine thiab kev thauj khoom ntawm cov saw ntev ntev fatty acids los ntawm cell daim nyias nyias, thiab tiv thaiv cov tsub zuj zuj ntawm cov ntaub ntawv ntawm unoxidized fatty acids nyob rau hauv cov cell - derivatives ntawm acylcarnitine thiab acylcoenzyme A.

Nyob rau hauv cov kev mob ntawm ischemia, nws rov qab kho qhov sib npaug ntawm cov txheej txheem ntawm kev xa oxygen thiab nws noj hauv hlwb, tiv thaiv kev ua txhaum ntawm ATP thauj, thiab tib lub sijhawm ua haujlwm glycolysis, uas tau nce tsis siv pa ntxiv. Raws li qhov txo qis hauv carnitine concentration, gamma-butyrobetaine nrog vasodilating cov khoom yog qhov sib zog ua ke. Tus txheej txheem ntawm kev txiav txim siab txiav txim siab ntau haiv neeg ntawm nws cov txiaj ntsig pharmacological: ua kom muaj kev ua tau zoo, txo cov tsos mob ntawm lub hlwb thiab lub cev kev ntxhov siab, ua kom cov nqaij mos thiab lub cev tsis muaj kev tiv thaiv, kev ua haujlwm cardioprotective.

Tus mob ischemic tsis zoo rau lub myocardium, nws qeeb qeeb qhov tsim ntawm thaj chaw necrotic thiab ua kom lub sijhawm rov ua kom sai. Nrog rau lub plawv tsis ua haujlwm, nws nce myocardial contractility, nce kev qoj ib ce zam, thiab txo qis zaus ntawm kev mob taub hau. Hauv kev mob siab thiab mob ntsws ischemic mob hlwb cerebral ncig txhim kho cov ntshav ncig hauv kev ua kom pom tseeb ntawm ischemia, pab txhawb txoj kev rov faib cov ntshav hauv kev pom zoo ntawm thaj chaw ischemic. Zoo rau vascular thiab dystrophic pathology ntawm lub fundus. Nws muaj lub zog ua kom lub zog ua rau lub hauv nruab nrab cov hlab hlwb, tshem tawm cov kev ua haujlwm tsis zoo ntawm cov hlab hlwb hauv cov neeg mob uas muaj cawv quav ntev nrog kev tshem tawm mob.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, nws nrawm los ntawm lub plab zom mov. Bioavailability yog li ntawm 78%. C_max hauv plasma tiav tiav 1-2 teev tom qab kev tswj hwm. Nws yog biotransformed nyob rau hauv lub cev nrog kev tsim ntawm ob lub cev tseem ceeb uas nthuav tawm los ntawm lub raum. T_1/2 yog 3-6 teev thiab nyob ntawm koob tshuaj.

Melfor kev sib cuam tshuam nrog lwm yam tshuaj

Txoj kev pheej hmoo ntawm kev txhim kho txoj hlab ntshav hypotension thiab tachycardia muaj txiaj ntsig tshwm sim vim yog siv Melfort tib lub sijhawm nrog cov tshuaj hauv qab no:

• cuab yeej siv vasodilators,
• alpha adrenergic blockers,
• antihypertensive cov neeg sawv cev
• nifedipine
• nitroglycerin.

Tsis tas li ntawd, thaum noj ua ke nrog cov mob glycosides, tshuaj antianginal, thiab ntxiv rau qee yam hom tshuaj tiv thaiv kab mob, lawv cov nyhuv ua lub suab ntau dua.

Noj ntau dhau

Txhaum ntawm kev noj tshuaj ntau dua, ib qho kev xav ntawm qhov tsis muaj zog, mob taub hau thiab kiv taub hau, kev txhim kho ntawm tachycardia, thiab txo qis ntshav siab tuaj yeem tshwm sim. Vim tias cov tshuaj no tsis muaj kuab lom, txhua qhov kev xav tsis yooj yim yooj yim ploj sai sai tom qab tus qauv kho mob.

Cov lus thiab cov xwm txheej ntawm kev cia

Lub txee lub neej ntawm cov tshuaj Melfor yog 24 lub hlis txij li hnub tso. Khaws nws nyob rau hauv qhov chaw qhuav thiab tsaus kom tsis txhob nkag tau rau menyuam yaus.

Cov cua kub yuav tsum tsis pub tshaj +25 degrees Celsius.

Cov tshuaj Melfor muaj muag hauv cov khw muag tshuaj. Nws tus nqi nruab nrab hauv Lavxias yog 500-560 rubles.

Hauv cov chaw muag tshuaj Ukrainian Koj tuaj yeem yuav Melfor tshuaj ntawm tus nqi ntawm 200 txog 250 hryvnia.

Qee qhov xwm txheej, yog tias cov tshuaj Melfor tsis haum, lossis tsis muaj qhov siv tau, koj yuav tsum them sai sai rau qhov hloov zoo tshaj plaws.

Cov nyiam tshiab tshaj plaws ntawm Melfora muaj xws li:

• Magnikor - ib qho kev npaj raws li acetylsalicylic acid thiab magnesium hydroxide, npaj rau kev kho mob ntawm cov mob plawv hauv cov mob tsis meej thiab mob ntev,
• Pumpan - cov tshuaj nyob rau hauv daim ntawv ntawm cov tee thiab ntsiav tshuaj rau txoj kev kho mob nyuaj ntawm txoj hlab ntshav siab, lub plawv tsis ua haujlwm, arrhythmia thiab qee yam lwm yam kev mob plawv,
• Cordaflex - cov ntsiav tshuaj chewable uas muaj lub ntsiab ua kom nquag plias nifedipine. Cov tshuaj no tau sau tseg rau cov kabmob angina pectoris, kev kub siab, kev mob ntshav siab, mob ntshav siab, thiab mob ntshav tawm ntawm lub cev, uas muaj qhov tsis sib xws,
• Corvitol - ntsiav tshuaj muaj metoprolol. Lawv siv rau kev kho mob ntawm cov mob plawv, mob myocardial infarction, angina pectoris, hyperthyroidism, kub siab, ntxiv rau mob plawv dhia tsis ua haujlwm,
• Kudesan yog cov tshuaj nyob rau hauv daim ntawv ntawm cov tee thiab ntsiav tshuaj raws ubidecarinone. Cov cim tseem ceeb rau lawv siv yog cov mob plawv, mob plawv, tsis ua haujlwm, tsis tuaj yeem ua haujlwm, nrog rau lub sijhawm rov qab los tom qab kev txom nyem myocardial infarction,
• Amlipin yog cov tshuaj sib xyaw ua ke raws li lisinopril thiab amlodipine, uas yog npaj rau kev kho mob plawv thiab mob ntshav tawm ntawm cov ntshav sib txawv,
• Bisoprol - ntsiav tshuaj raws bisoprol fumarate, npaj rau kev kho mob ntawm angina pectoris, mob plawv tsis ua hauj lwm ntev, thiab tseem mob ntshav liab.

Vim tias nws cov txiaj ntsig zoo thiab kev coj ua tsis raug ntawm kev mob tshwm sim, cov tshuaj Melfor tau txais kev tshuaj xyuas zoo los ntawm cov neeg mob thiab kws kho mob. Cov ntsiab lus tuaj yeem pom tom qab kawg ntawm tsab xov xwm no.

Cov tib neeg uas tau noj tshuaj noj tshuaj sau tseg tias nws muaj txiaj ntsig zoo rau lub xeev ntawm cov hlab plawv thiab cov txheej txheem ntawm cov hlab hlwb. Nws tseem ua rau kom rov qab ceev tshaj plaws ntawm cov rog thiab nce kev ua haujlwm.

Yog tias koj muaj koj tus kheej kev paub dhau los ntawm kev kho nrog kev siv tshuaj Melfor, nco ntsoov qhia koj cov kev xav rau lwm tus neeg tuaj saib lub vev xaib, tawm hauv kev tshuaj xyuas.