Lantus SoloStar - nom * cov lus qhia rau siv

Cov tshuaj insulin glargine yog ib qho piv txwv ntawm tib neeg cov tshuaj insulin, tus cwj pwm los ntawm solubility tsawg hauv qhov nruab nrab tsis zoo. Raws li ib feem ntawm kev npaj Lantus, nws yog soluble kiag li, uas tau ua kom muaj cov acidic ib puag ncig ntawm kev daws rau kev txhaj tshuaj (pH4). Tom qab qhia txog cov roj ntsha subcutaneous, txoj kev daws teeb meem, vim nws cov acidity, nkag mus rau hauv kev cuam tshuam nruab nrab nrog kev tsim cov microprecipitate, los ntawm cov tshuaj insulin glargine tso tawm tas li, muab qhov ua kom pom tseeb, du (tsis muaj peaks) profile ntawm qhov nkhaus-sijhawm nkhaus, nrog rau lub sijhawm ua haujlwm ntev dua.

Kev sib txuas lus nrog insulin receptors: cov lus sib khi rau cov insulin glargine thiab tib neeg cov insulin receptors yog qhov sib ze heev, thiab nws muaj peev xwm los tawm kev lom neeg uas zoo ib yam li insulin endogenous.

Qhov kev txiav txim siab tseem ceeb tshaj plaws ntawm insulin, thiab vim li no insulin glargine, yog kev cai ntawm cov metabolism hauv cov piam thaj. Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib los ntawm kev ua kom cov piam thaj los ntawm qhov nqaij (tshwj xeeb cov leeg pob txha thiab cov nqaij mos), nrog rau qhov ua kom cov ntshav qabzib nyob hauv lub siab (gluconeogenesis). Cov tshuaj insulin inhibits adipocyte lipolysis thiab proteolysis, thaum ua kom cov protein synthesis zoo.

Lub sijhawm ntev ntawm kev ua ntawm insulin glargine yog ncaj qha ntsig txog qhov txo tus nqi ntawm nws qhov nqus, uas tso cai rau cov tshuaj no siv ib hnub ib zaug. Tom qab kev tswj hwm sc, qhov pib ntawm kev tshwm sim tshwm sim, nyob rau nruab nrab, tom qab 1 teev Lub sijhawm nruab nrab ntawm kev ua yog 24 teev, qhov siab tshaj yog 29 teev.

Ntev ntshav Insulin - Nta ntawm Kev Kho Mob Ntshav Qab Zib

Nrog rau tus kab mob, ntshav qab zib yuav tsum tau muaj kev txhawb nqa insulin. Cov tshuaj insulin luv thiab insulin ntev ntev raug siv los kho tus mob. Qhov zoo ntawm lub neej ntawm cov ntshav qab zib feem ntau nyob ntawm kev ua raws li tag nrho cov tshuaj kho mob.

Yuav tsum siv cov insulin txuas mus tau sai thaum yoo cov ntshav cov piam thaj kom yuav tsum hloov kho. Cov insulins uas siv tau ntev tshaj plaws rau hnub no yog Levemir thiab Lantus, uas tus neeg mob yuav tsum tau noj ib zaug txhua 12 lossis 24 teev.

Cov insulin ntev ntev muaj qhov cuab yeej zoo, nws muaj peev xwm ntsi xws li lub cev ntuj tsim uas tsim los ntawm cov hlwb ntawm cov txiav. Tib lub sijhawm, nws yog maj rau ntawm cov hlwb zoo li ntawd, txhawb lawv txoj kev zoo rov los, uas yav tom ntej tso cai tsis kam hloov kho insulin.

Kev hno cov tshuaj insulin ntev ntev yuav tsum tau muab rau cov neeg mob uas muaj qib siab qab zib thaum nruab hnub, tab sis nws yuav tsum xyuas kom tus neeg mob noj zaub mov tsis pub dhau 5 teev ua ntej yuav mus pw. Tsis tas li, cov insulin ntev yog tsim rau cov tsos mob ntawm "thaum sawv ntxov kaj ntug", nyob rau hauv rooj plaub thaum lub siab mob pib thaum hmo ntuj ua ntej tus neeg mob sawv, ua kom tsis txhob muaj cov tshuaj insulin.

Yog hais tias luv luv insulin xav tau txhaj thaum nruab hnub kom txo tau cov ntshav qabzib nrog cov zaub mov, tom qab ntawd ntev insulin tuaj yeem tiv thaiv insulin keeb kwm yav dhau los, ua qhov kev tiv thaiv zoo tshaj plaws ntawm ketoacidosis, nws kuj pab rov qab rau pancreatic beta hlwb.

Kev txhaj tshuaj ntawm cov tshuaj insulin txuas ntxiv tsim nyog tau txais kev mloog uas lawv pab ua rau tus neeg mob hauv lub cev thiab ua kom cov ntshav qab zib ntawm yam thib ob tsis kis mus rau thawj hom kabmob.

Cov Tshuaj Pharmacokinetics

Kev sib piv kev kawm txog cov ntsiab lus ntawm cov tshuaj insulin glargine thiab insulin-isofan nyob rau hauv cov ntshav ntshav hauv cov neeg muaj mob thiab cov neeg mob ntshav qab zib mellitus tom qab sc tswj kev siv tshuaj tau qhia qeeb dua thiab ntev dua qhov kev nqus, nrog rau qhov tsis muaj lub siab tshaj plaws hauv insulin glargine piv rau insulin-isofan Cov.

Nrog rau ib qho SC thawj coj ntawm Lantus ib zaug ib hnub, ib qho kev ruaj khov nruab nrab ntawm cov tshuaj insulin glargine hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug.

Nrog kev tswj hwm iv, ib nrab-lub neej ntawm insulin glargine thiab insulin tib neeg tau sib piv.

Hauv ib tus neeg nyob rau hauv cov roj ntsha subcutaneous, insulin glargine yog ib feem los ntawm carboxyl kawg (C-terminus) ntawm B saw (Beta saw) los ua 21 A -Gly-insulin thiab 21 A -Gly-des-30 B -Thr-insulin. Hauv ntshav, ob qho tib si tsis hloov pauv ntawm insulin glargine thiab nws cov khoom kom txav tau yooj yim.

Qhov tseeb muab xam ntawm cov koob tshuaj ntawm cov insulin ntev thaum hmo ntuj

Txhawm rau kom lub neej tsis muaj sia nyob, tus neeg mob yuav tsum tau kawm paub ntsuas cov tshuaj noj kom zoo ntawm Lantus, Protafan lossis Levemir thaum hmo ntuj, kom cov qib nrawm nrawm nrog rau ntawm 4.6 ± 0.6 mmol / l.

Ua li no, nyob hauv lub limtiam koj yuav tsum ntsuas qib suab thaj thaum hmo ntuj thiab sawv ntxov thaum lub plab khoob. Tom qab ntawd koj yuav tsum xam qhov txiaj ntsig ntawm qab zib thaum sawv ntxov tshaj tawm nag hmo tus nqi thaum hmo ntuj thiab suav qhov nce qhov nce, qhov no yuav muab qhov ntsuas ntawm qhov tsawg kawg yuav tsum tau noj.

Piv txwv li, yog tias qhov nce qib ntawm thaj suab thaj tsawg tshaj plaws yog 4.0 mmol / l, tom qab ntawd 1 ntu ntawm cov tshuaj insulin ntev tuaj yeem txo qhov ntsuas no los ntawm 2.2 mmol / l hauv ib tus neeg hnyav 64 kg. Yog tias koj qhov hnyav hnyav 80 kg, tom qab ntawd peb siv cov qauv hauv qab no: 2.2 mmol / L * 64 kg / 80 kg = 1.76 mmol / L.

Qhov koob tshuaj ntawm cov tshuaj insulin rau ib tus neeg uas hnyav 80 kg yuav tsum yog 1.13 units, tus lej no yog muab kwv yees mus rau lub quarter ze thiab peb tau txais 1.25E.

Nws yuav tsum raug sau tseg tias Lantus tsis tuaj yeem raug diluted, yog li nws yuav tsum tau txhaj nrog 1ED lossis 1,5ED, tab sis Levemir tuaj yeem raug txhaws thiab txhaj nrog qhov yuav tsum muaj tus nqi. Hauv ob peb hnub tom qab no, koj yuav tsum tau soj ntsuam seb cov piam thaj sai npaum li cas thiab yuav ua rau ntau ntxiv lossis ntau npaum li cas.

Nws yog xaiv qhov raug thiab raug yog tias, hauv ib lub lis piam, cov piam thaj sai dua tsis tshaj 0.6 mmol / l, yog tias tus nqi ntau dua, ces sim nce qhov ntau npaum ntawm 0.25 units txhua peb hnub.

Cev xeeb tub thiab lactation

Hauv cov kev tshawb fawb tsiaj, tsis muaj cov ntaub ntawv ncaj qha lossis tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine.

Txog tam sim no, tsis muaj txheeb cais hais txog kev siv cov tshuaj thaum cev xeeb tub. Muaj pov thawj ntawm kev siv Lantus hauv 100 tus poj niam cev xeeb tub muaj ntshav qab zib. Cov chav kawm thiab kev tshwm sim ntawm cev xeeb tub hauv cov neeg mob no tsis txawv ntawm cov poj niam cev xeeb tub uas muaj ntshav qab zib uas tau txais lwm yam tshuaj insulin.

Kev teem caij ntawm Lantus hauv cov poj niam cev xeeb tub yuav tsum tau ua nrog ceev faj. Rau cov neeg mob uas muaj kab mob ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj kev cai tsim nyog ntawm cov khoom noj hauv lub cev thoob plaws lub cev xeeb tub. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntxiv thaum lub sijhawm thib ob thiab thib peb. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Hauv cov pojniam muaj menyuam, kev txhaj tshuaj thiab noj zaub mov kom haum.

Thaum yuav siv cov tshuaj

Ib cov tshuaj yog siv rau cov ntshav qab zib, uas yuav tsum tau kho nrog insulin. Ntau zaus nws yog ntshav qab zib hom 1. Qhov tshuaj hormone no tuaj yeem kho rau txhua tus neeg mob uas muaj hnub nyoog 6 xyoo.

Kev siv tshuaj insulin ntev ntev yog qhov tsim nyog los tswj lub cev ceev ceev hauv cov ntshav cov neeg mob cov ntshav. Tus neeg noj qab haus huv hauv cov hlab ntshav yeej ib txwm muaj qee qhov ntawm no, xws li cov ntsiab lus hauv cov ntshav yog hu ua theem pib.

Hauv cov neeg mob uas muaj ntshav qab zib mellitus nyob rau hauv rooj plaub ntawm pancreatic kawg, xav tau cov tshuaj insulin, uas yuav tsum tau txhaj tshuaj tsis tu ncua.

Lwm qhov kev xaiv rau kev tso tawm cov tshuaj hormone hauv ntshav tau hu ua bolus. Nws cuam tshuam nrog kev noj mov - hauv kev teb rau kev nce siab hauv cov ntshav qab zib, qee qhov ntshav ntawm insulin raug tso tawm kom sai glycemia li qub.

Hauv cov ntshav qab zib mellitus, insulins luv luv tau siv rau qhov no.Hauv qhov no, tus neeg mob yuav tsum txhaj nws tus kheej nrog rab koob txhaj tshuaj txhua lub sijhawm tom qab noj mov, nws muaj cov khoom tsim nyog ntawm cov tshuaj hormones.

Hauv cov tsev muag tshuaj, coob tus muab tshuaj sib txawv rau kev kho mob ntshav qab zib tau muag. Yog tias tus neeg mob xav tau siv lub cev ntev ua cov tshuaj hormones, tom qab ntawd dab tsi yog qhov zoo siv - Lantus lossis Levemir? Ntau txoj hauv kev, cov tshuaj no zoo sib xws - ob qho tib si yog qhov pib, yog qhov ua kwv yees thiab ruaj khov nyob rau hauv kev siv.

Peb yuav xyuas seb cov tshuaj hormones no txawv li cas. Nws ntseeg tias Levemir muaj lub neej ua haujlwm ntev dua li Lantus Solostar - txog 6 lub lim tiam tiv thaiv ib hlis. Yog li no, Levemir pom tau tias yooj yim dua rau kis uas koj xav tau nkag rau qhov qis ntawm cov tshuaj, piv txwv li, ua raws li cov zaub mov tsis muaj carb qis.

Cov kws txawj hais tias Lantus Solostar yuav ua rau muaj kev pheej hmoo mob qog noj ntshav, tab sis tsis muaj ntaub ntawv txaus ntseeg ntawm qhov no tseem.

Glargin thiab lwm yam tshuaj

Kev sib xyaw nrog lwm cov tshuaj cuam tshuam rau cov txheej txheem metabolic txuam nrog cov piam thaj:

1. Qee cov tshuaj txhim kho cov nyhuv ntawm Lantus. Cov no suav nrog sulfonamides, salicylates, tshuaj noj ntawm qhov ncauj-txo qhov ncauj, ACE thiab MAO inhibitors, thiab lwm yam.
2. Diuretics, sympathomimetics, protease inhibitors, antipsychotics nkaus xwb, cov tshuaj hormones - poj niam, cov thyroid, thiab lwm yam tsis muaj zog cov kev cuam tshuam ntawm insulin glargine.
3. Kev nqus cov roj ntsha lithium, kev tiv thaiv beta-blockers lossis kev haus cawv ua rau muaj qhov tsis meej xwm - txhim kho lossis txo cov nyhuv ntawm cov tshuaj.
4. Noj pentamidine nyob rau hauv parallel nrog Lantus ua rau muaj kev ntsia hlau loj nyob rau hauv cov piam thaj, qhov kev hloov pauv ntse los ntawm ib qho zuj zus mus rau qhov nce.

Feem ntau, cov tshuaj muaj cov tshuaj xyuas zoo. Tus nqi insulin glargin raug nyiaj npaum li cas? Tus nqi ntawm cov nyiaj hauv thaj tsam thaj tsam li 2500-4000 rubles.

Peb yuav txheeb xyuas seb yuav siv Lantus li cas - cov lus qhia rau kev siv hais tias nws yuav tsum tau txhaj tshuaj rau hauv cov ntaub so ntswg ntawm lub plab phab ntsa sab xub ntiag, thiab nws tsis tuaj yeem siv tshuaj ntxau. Qhov qauv ntawm cov tshuaj saib xyuas yeeb tshuaj no yuav ua rau txo qis cov ntshav qabzib hauv lub ntsej muag thiab kev txhim kho ntawm lub ntsej muag hypoglycemic.

Ntxiv nrog rau fiber ntau ntawm lub plab, muaj lwm qhov chaw rau qhov kev qhia tau ntawm Lantus - cov pob txha hauv plab, cov leeg nqaij deltoid. Qhov sib txawv hauv cov nyhuv hauv cov xwm txheej no tsis txaus ntseeg lossis tsis tuaj kiag li.

Qhov tshuaj tsis tuaj yeem ua ke ua ke nrog lwm cov tshuaj insulin, nws tsis tuaj yeem xeb ua ntej siv, vim qhov no txo ​​nws cov hauj lwm zoo. Yog tias sib xyaw nrog lwm cov tshuaj pharmacological, dej nag yog tau.

Txhawm rau kom ua tau zoo kho mob, Lantus yuav tsum tau siv txuas ntxiv, txhua txhua hnub nyob rau tib lub sijhawm.

Yuav siv hom tshuaj insulin li cas rau cov ntshav qab zib, kws kho mob endocrinologist yuav qhia koj. Muaj qee kis, kev siv yeeb-tshuaj luv luv tuaj yeem muaj peev xwm kis nrog qee zaum; qee zaum yuav tsum tau muab ob qho tshuaj insulins luv thiab ntev ntev. Ib qho piv txwv ntawm kev sib koom ua ke no yog kev sib koom ua ke ntawm Lantus thiab Apidra, lossis kev sib txuam xws li Lantus thiab Novorapid.

Hauv cov xwm txheej ntawd thaum, rau qee qhov laj thawj, nws yuav tsum hloov Lantus Solostar npaj mus rau lwm qhov (piv txwv, rau Tujeo), qee cov cai yuav tsum tau ua. Qhov tseem ceeb tshaj plaws, kev hloov pauv yuav tsum tsis txhob muaj kev nyuaj siab ntxiv rau lub cev, yog li koj tsis tuaj yeem txo qis dua ntawm cov tshuaj raws li cov lej ntawm qhov kev txiav txim.

Ntawm qhov tsis sib xws, nyob rau thawj hnub ntawm kev tswj hwm, kev nce ntxiv ntawm cov tshuaj insulin yog ua tau kom thiaj li yuav zam tau hyperglycemia. Thaum txhua lub cev hloov mus rau txoj kev siv tshuaj tshiab zoo tshaj plaws, koj tuaj yeem txo qhov koob tshuaj rau tus nqi ib txwm muaj.

Txhua yam kev hloov pauv hauv txoj kev kho, tshwj xeeb yog hais txog kev hloov cov tshuaj nrog cov analogues, yuav tsum muaj kev pom zoo nrog cov kws kho mob koom nrog, uas paub tias ib hom tshuaj txawv ntawm lwm qhov twg thiab qhov twg zoo dua.

Qhov yuav tsum tau siv rau lwm pab pawg ntawm cov tshuaj rau kev kho mob yuav tsum tau ceeb toom ua ntej rau tus kws kho mob uas koom nrog. Qee cov tshuaj, cuam tshuam nrog Lantus, txhim kho nws cov nyhuv, thaum lwm tus, ntawm qhov tsis tooj, inhibit nws, ua rau nws tsis tuaj yeem tau txais kev kho kom zoo.

Cov tshuaj uas txhim kho qhov kev txiav txim ntawm Lantus:

• inhibitors
• antimicrobial tus neeg sawv cev
• ib pawg ntawm salicylates, fibrates,
• Fluoxetine.

Lawv txoj kev tswj hwm tib lub sijhawm tuaj yeem ua rau cov ntshav qab zib dhia thiab cov ntshav glycemia muaj zog. Yog tias nws tsis tuaj yeem thim cov nyiaj no, nws yog ib qho tsim nyog yuav tau kho cov tshuaj ntawm cov tshuaj insulin.

Kev qaug zog ntawm qhov ua tau zoo ntawm cov tshuaj tuaj yeem tshwm sim thaum nws cuam tshuam nrog cov tshuaj diuretic, ib pawg estrogens thiab progestogens, thiab atypical antipsychotics. Cov tshuaj hormones kho mob kho cov thyroid pathology thiab endocrine system tuaj yeem ua kom cov nyhuv qog ntshav hypoglycemic ntawm Lantus.

Nws raug nquahu kom tsis txhob haus dej cawv thiab siv tshuaj ntawm pawg beta-blocker rau kev kho mob, uas tuaj yeem txo ob txoj kev ua haujlwm ntawm cov tshuaj thiab ua rau glycemia, nyob ntawm qhov ntau thiab tus kheej cov yam ntxwv ntawm tus neeg mob lub cev.

Kev sib txuam tshuaj nrog ntau cov tshuaj tuaj yeem cuam tshuam cov metabolism hauv cov piam thaj. Cov tshuaj hauv qab no cuam tshuam rau kev nqis tes ntawm Lantus raws li cov lus qhia:

• Cov tshuaj uas txhim kho qhov kev ua ntawm Lantus (insulin glargine) - ACE inhibitors, tshuaj tiv thaiv hypoglycemic, MAO inhibitors, fluoxetine, fibrates, disopyramides, propoxyphene, pentoxifylline, sulfonamide tshuaj thiab salicylates,
• Cov tshuaj uas ua rau cov nyhuv tsis muaj zog ntawm Lantus (insulin glargine) - GCS, diazoxide, danazole, diuretics, gestagens, estrogens, glucagon, isoniazid, somatotropin, phenothiazine derivatives, sympathomimetics (epinephrine, terbutaline, salbutamolum), protease inhibitors los yog qee yam tshuaj tiv thaiv nerogen. cov thyroid hormones
• Ob leeg txhim kho thiab ua kom cov nyhuv ntawm Lantus (insulin glargine) beta-blockers, lithium ntsev, clonidine, cawv,
• Qhov tsis txaus ntseeg ntawm cov piam thaj hauv cov ntshav nrog kev hloov pauv ntawm hypoglycemia rau hyperglycemia tuaj yeem ua rau tib lub sijhawm tswj hwm ntawm Lantus nrog pentamidine,
• Cov tsos mob ntawm adrenergic counterregulation tuaj yeem txo lossis ncua sijhawm thaum noj cov tshuaj sympatholytic - guanfacin, clonidine, reserpine thiab beta-blockers.

Txoj kev ntawm daim ntawv thov

Hauv kev siv, ua raws li txoj cai:

1. Cov lus qhia ntawm cov tshuaj yog nqa tawm hauv subcutaneous rog txheej ntawm tus ncej puab lossis lub xub pwg, pob tw, lub plhaw thawj thaj tsam. Cov tshuaj siv ib zaug ib hnub, thaj chaw txhaj tshuaj hloov, thiab kev sib luag sib luag yog tswj ntawm qhov hno tshuaj.
2. Qhov ntau npaum li cas thiab lub sijhawm ntawm kev txhaj tshuaj yog txiav txim los ntawm tus kws kho mob - cov kev txwv no yog tus neeg. Cov tshuaj siv tsuas yog siv ib leeg los yog ua ke nrog lwm cov tshuaj uas tsim los txo cov ntshav hauv qab ntuj.
3. Txoj kev txhaj tshuaj tsis haum lossis diluted nrog cov tshuaj insulin.
4. Cov tshuaj ua haujlwm zoo thaum muab tshuaj rau hauv qab daim tawv, yog li nws tsis pom zoo kom txhaj tshuaj rau qhov ntswg.
5. Thaum tus neeg mob hloov mus rau cov tshuaj insulin glargine, kev saib xyuas ntshav qab zib cov ntshav yog tsim nyog rau 14-21 hnub.

Thaum hloov cov tshuaj, cov kws tshwj xeeb xaiv cov txheej txheem raws li cov ntaub ntawv ntawm tus neeg mob tshuaj ntsuam thiab coj mus rau hauv tus yam ntxwv ntawm nws lub cev. Insulin rhiab heev dhau sij hawm vim qhov kev txhim kho ntawm cov txheej txheem kev cai metabolic, thiab kev pib qhov pib ntawm cov tshuaj yuav txawv.

Kev kho ntawm kev tswj hwm kuj yog qhov tsim nyog rau kev hloov pauv ntawm lub cev lub cev, hloov kev ua haujlwm, kev hloov pauv sai sai hauv txoj kev ua neej, uas yog, nrog rau cov ntsiab lus uas tuaj yeem ua rau lub siab rov qab rau qhov siab lossis qis qis qhov tseem ceeb.

Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum kev ua haujlwm tuaj yeem ua rau txo qis cov tshuaj insulin tsis tu ncua.

P / c. Cov neeg loj thiab me nyuam muaj hnub nyoog tshaj 2 xyoos.

Lantus® SoloStar® yuav tsum tau txhaj tshuaj sc ib zaug ib hnub nyob rau txhua lub sijhawm ntawm hnub, tab sis txhua hnub nyob rau tib lub sijhawm.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus® SoloStar® tuaj yeem siv ob qho tib si li monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic.

Lub hom phiaj ntawm cov ntshav qab zib ntau, nrog rau cov koob tshuaj thiab lub sijhawm ntawm kev tswj hwm lossis kev tswj hwm ntawm cov tshuaj ntshav qog ntshav yuav tsum txiav txim siab thiab kho tus kheej.

Kev hloov kho koob tshuaj kuj tseem yuav tsum tau ua, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, hloov lub sijhawm ntawm kev saib xyuas ntawm cov tshuaj insulin, lossis lwm qhov xwm txheej uas yuav ua rau muaj kev cuam tshuam rau kev txhim kho hypo- lossis hyperglycemia (saib "Cov lus qhia tshwj xeeb"). Txhua qhov kev hloov pauv ntawm cov koob tshuaj insulin yuav tsum tau ua nrog ceev faj thiab kev saib xyuas mob.

Lantus® SoloStar® tsis yog qhov insulin ntawm kev xaiv rau kev kho mob ntshav qab zib ketoacidosis. Hauv qhov no, kev nyiam yuav tsum tau muab rau hauv / hauv kev qhia luv luv ntawm kev ua yeeb yam insulin.

Hauv cov txheej txheem kho mob suav nrog kev txhaj tshuaj insal basal thiab prandial insulin, 40-60% ntawm cov tshuaj insulin txhua hnub hauv daim ntawv ntawm insulin glargine feem ntau yog siv kom tau raws li qhov xav tau ntawm insulin basal.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, siv cov tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj, kev sib xyaw ua ke pib nrog ib koob tshuaj insulin glargine 10 PIECES ib hnub ib zaug, thiab hauv kev kho mob tom ntej yog kho tus kheej.

Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic rau Lantus® SoloStar®

Thaum hloov cov neeg mob los ntawm cov txheej txheem kev kho mob uas siv nruab nrab ntev lossis ntev ntev rau cov tshuaj insulin rau kev kho mob uas siv cov tshuaj Lantus® SoloStar® kev npaj, nws yuav tsim nyog kho qhov ntau (ntau npaum li cas) thiab lub sijhawm ntawm kev tswj hwm ntawm luv luv ua yeeb yam insulin lossis nws cov tshuaj tiv thaiv thaum nruab hnub lossis hloov cov tshuaj ntawm qhov ncauj hypoglycemic tshuaj Cov.

Thaum hloov cov neeg mob los ntawm ib qho kev txhaj tshuaj ntawm cov tshuaj insulin-isofan nyob rau ib hnub rau ib txoj kev tswj hwm ntawm cov tshuaj thaum nruab hnub, Lantus® SoloStar®, cov tshuaj tiv thaiv thawj zaug feem ntau tsis hloov pauv (i.e., qhov ntau ntawm U / hnub ntawm Lantus® SoloStar® tau siv, sib npaug ntawm tus nqi ntawm IU / hnub tshuaj insulin isophane).

Thaum hloov cov neeg mob los ntawm kev tswj hwm cov tshuaj insulin-isophan ob zaug thaum nruab hnub rau ib qho kev tswj hwm ntawm Lantus® SoloStar® ua ntej yuav mus pw kom txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab thaum sawv ntxov ntxov, qhov kev pib noj txhua hnub ntawm insulin glargine feem ntau yog txo 20% (piv nrog qhov tshuaj txhua hnub insulin-isophane), thiab tom qab ntawd nws raug hloov kho nyob ntawm tus neeg mob cov lus teb.

Lantus® SoloStar® yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulin los yog ua kom sib xyaw. Koj yuav tsum paub tseeb tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj. Thaum muab sib xyaw los yog zom, qhov profile ntawm insulin glargine yuav hloov lub sijhawm.

Thaum hloov los ntawm tib neeg cov tshuaj insulin mus rau Lantus® SoloStar® thiab thaum thawj lub lis piam tom qab nws, ceev faj kev ntsuas metabolic (saib xyuas cov ntshav qabzib hauv cov ntshav) nyob rau hauv kev saib xyuas mob tau pom zoo, nrog kev kho cov tshuaj ntau ntxiv ntawm cov insulin yog tias tsim nyog.

Ib yam li lwm cov duab ntawm tib neeg cov tshuaj insulin, qhov no tshwj xeeb tshaj yog rau cov neeg mob, vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin, yuav tsum tau siv cov koob tshuaj ntau kawg ntawm tib neeg cov insulin.

Hauv cov neeg mob no, thaum siv insulin glargine, muaj kev txhim kho tseem ceeb hauv cov lus teb rau kev tswj hwm insulin tuaj yeem pom.

Txoj kev siv tshuaj Lantus® SoloStar®

Cov tshuaj Lantus® SoloStar ® raug muab tshuaj raws li s / c txhaj tshuaj. Tsis tau npaj rau kev tswj hwm iv.

Lub sijhawm ntev ntawm kev ua ntawm insulin glargine yog pom tsuas yog thaum nws qhia rau hauv cov rog subcutaneous. Hauv / hauv kev qhia ntawm cov tshuaj subcutaneous li niaj zaus tuaj yeem ua rau mob ntshav qab zib heev.

Lantus® SoloStar® yuav tsum tau txhaj rau cov roj ntsha hauv plab, xub pwg lossis lub duav. Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv nrog txhua qhov kev txhaj tshuaj tshiab hauv thaj chaw pom zoo rau kev tswj hwm sc ntawm cov tshuaj.

Xws li lwm hom tshuaj insulin, qhov siab ntawm kev nqus, thiab vim li ntawd qhov pib thiab lub sijhawm ntawm nws qhov kev ua, tuaj yeem hloov pauv nyob rau ntawm tus yam ntxwv ntawm lub cev thiab lwm yam kev hloov pauv ntawm tus neeg mob lub cev.

Lantus® SoloStar® yog cov kev daws teeb meem, tsis raug ncua. Yog li ntawd, rov kho dua ua ntej siv tsis tas.

Yog tias Lantus® SoloStar® koob txhaj tshuaj tsis ua haujlwm, cov tshuaj insulin glargine tuaj yeem tshem tawm los ntawm daim cartridge mus rau hauv cov koob txhaj tshuaj (haum rau insulin 100 IU / ml) thiab qhov tsim nyog yuav tau txhaj.

Cov lus qhia rau kev siv thiab tuav ntawm cov xaum ua ntej xaum xaum SoloStar®

Ua ntej siv thawj zaug, rab koob xaum xaum yuav tsum khaws cia ntawm chav tsev li 1-2 teev.

Ua ntej siv, tshawb xyuas daim cartridge sab hauv daim ntawv xaum. Nws yuav tsum siv tsuas yog hais tias qhov kev daws teeb meem yog pob tshab, xim, tsis muaj qhov pom ntawm cov khoom thiab thiab zoo sib xws, cuam tshuam nrog dej.

Lub cev tsis siv SoloStar ® cov koob txhaj tshuaj yuav tsum tsis tau siv thiab muab pov tseg.

Txhawm rau tiv thaiv kev kis mob, tus cwj mem uas muaj menyuam qhwv ua ntej tsuas yog siv los ntawm ib tus neeg mob thiab yuav tsum tsis txhob hloov mus rau lwm tus.

Kev Siv SoloStar® Syringe Cwj mem

Ua ntej siv SoloStar® Syringe Cwj mem, ua tib zoo nyeem cov lus qhia siv.

Cov ntaub ntawv tseem ceeb ntawm kev siv SoloStar® Syringe Cwj mem

Ua ntej siv txhua qhov, ua tib zoo txuas lub koob tshiab rau daim duab xaum xaum thiab kev sim kev nyab xeeb. Tsuas siv cov koob uas txuam nrog SoloStar ® yuav tsum siv.

Cov kev tiv thaiv tshwj xeeb yuav tsum tau ceev faj kom tsis txhob muaj kev sib tsoo nrog kev siv koob thiab qhov kis tau ntawm kev kis tus mob.

Txawm li cas los xij koj yuav tsum siv SoloStar® koob txhaj tshuaj yog tias nws puas ntsoog lossis yog koj tsis paub meej tias nws yuav ua haujlwm tau zoo.

Nws yog ib txwm tsim nyog yuav tsum muaj SoloStar ® syringe cwj mem thaum koj poob lossis ua rau daim ntawv dhau ntawm SoloStar® koob txhaj tshuaj.

Ntu Kev Khaws Cia Cov Khoom yuav tsum kuaj xyuas nrog txoj cai khaws cia ntawm SoloStar® Syringe Cwj mem.

S / c, hauv cov roj ntsha hauv qab ntawm lub plab, sab xub pwg lossis ncej puab, ib txwm tib lub sijhawm 1 zaug hauv ib hnub. Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv nrog txhua qhov kev txhaj tshuaj tshiab hauv thaj chaw pom zoo rau kev tswj hwm sc ntawm cov tshuaj.

Hauv / hauv kev qhia ntawm cov koob tshuaj ib txwm, npaj rau sc tswj hwm, tuaj yeem ua rau kev txhim kho ntshav nce siab ntau dhau.

Cov koob tshuaj ntawm Lantus thiab lub sijhawm ntawm hnub rau nws cov kev taw qhia tau xaiv ib tus zuj zus. Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus tuaj yeem siv ob qho tib si li monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic.

Cov tshuaj ntawm glargine tsuas yog xaiv los ntawm tus kws kho mob koom nrog ib tus zuj zus rau txhua tus neeg mob. Qhov kev txhaj tshuaj yog ua rau subcutaneously hauv qhov rog quav hauv lub plab, hips, xub pwg. Qhov kev txhaj tshuaj yog txhaj ib zaug hauv ib hnub, nyob rau tib lub sijhawm. Thaum muaj kev sib cuam tshuam nrog lwm cov tshuaj noj los ntawm tus neeg mob, ua kom qaug zog los yog sib zog ntawm kev ua yog tau.

Hloov cov tshuaj ntxiv ntawm glargine yog tias:

• Kev hloov pauv ntawm cov duab sib dhos ntawm lub neej.
• Qhov hnyav los sis ceeb thawj.
• Noj Mov Pauv Hloov.
• Kev phais mob.
• Raum tsis ua haujlwm.
• Kev kis mob.
• Cov tsos mob ntawm hypo- lossis hyperthyroidism.

Glargin muaj ntau cov kev mob tshwm sim:

• Muaj hws ntau.
• Mob taub hau.
• Lub plawv palpitations.
• O o.

Kev noj ntau dhau ua rau lub plab tsis nco qab yuav tsum zam.

Glargine cov npe lag luam yog Lantus, Lantus SoloStar, Insulin Glargine, Tujeo SoloStar. Cov tshuaj siv yog siv hauv kev kho tshuaj tiv thaiv kab mob ntshav qab zib insulin-mellitus hauv cov laus thiab cov menyuam yaus hnub nyoog tshaj li rau xyoo. Glargine thiab analogues yog contraindicated nyob rau hauv cov ntaub ntawv ntawm hypersensitivity rau lawv lub Cheebtsam thiab cov menyuam yaus hnub nyoog qis dua 6 xyoo. Ceev faj yog siv thaum nqa tus menyuam thiab pub niam mis.

Kev siv cov glargine tso cai kom ua tiav cov nyhuv hypoglycemic tseem ceeb nrog qhov txo qis ntawm qhov tseem ceeb ntawm glycemia thiab glycated hemoglobin. Hloov chaw tej zaum yuav tsis zoo li.

Qhov tsis muaj qhov tseem ceeb contraindications, nrog rau kev ua haujlwm siab, yog qhov muaj txiaj ntsig txaus rau kev pom zoo rau cov neeg mob ntshav qab zib hom 2 rau kev kho mob nkaus xwb, nrog rau kev sib xyaw nrog cov piam thaj txo cov ntsiav tshuaj thiab luv luv insulins.

Lantus yog tsim los kho cov teeb meem cuam tshuam nrog theem siab thiab qis qab zib. Nws yuav tsum raug tswj tsuas yog nyob hauv qab ntawm daim tawv nqaij thiab raug txwv tsis pub - txog leeg.

Lub sijhawm ntev ua haujlwm ntawm cov tshuaj yog vim qhov tseeb tias nws tau nkag mus rau cov roj ntsha subcutaneous. Peb yuav tsum tsis txhob hnov ​​qab tias qhov kev qhia ntawm cov tshuaj ib txwm tso rau hauv tuaj yeem ua rau qhov kev txhim kho ntawm cov ntshav khov qis.

Ua cov txheej txheem ib hnub ib zaug tib lub sijhawm. Kev txhaj tshuaj rau hauv qhov ncauj kom zoo yuav tsum nruj me ntsis. Txhawm rau kom tsis txhob lipodystrophy, hloov thaj chaw txhaj tshuaj.

Cov koob tshuaj ntawm cov tshuaj yog nyob ntawm qhov hnyav ntawm tus neeg mob, nws txoj kev ua neej thiab lub sijhawm ntawm kev tswj hwm ntawm cov tshuaj. Nws yog tus xaiv los ntawm tus kws kho mob.

Tsuas xaiv yuav tsum tau thaum hloov qhov hnyav ntawm tus neeg mob lossis nws txoj kev ua neej. Tsis tas li, qhov ntau npaum li cas ntawm cov tshuaj yog nyob ntawm lub sijhawm ntawm nws txoj kev tswj hwm.

Raws li cov lus qhia, Lantus (insulin glargine) yog qhia nyob rau hauv cov ntaub ntawv ntawm:

• Hom I ntshav qab zib mellitus (insulin-dependant),
• Hom Ntshav Qab Zib II mellitus (non-insulin-dependant) nyob rau theem ntawm kev ua rau kev cuam tshuam ntawm qhov ncauj ntawm cov tshuaj ntshav qab zib, cov kab mob sib kis thiab kev xeeb tub.

Txhawm rau siv Lantus raws li cov lus qhia, cov cai hauv qab no yuav tsum nruj me ntsis:

• Txhawm rau hno cov tshuaj rau hauv cov nqaij ntshiv subcutaneous ntawm tus ncej puab, lub xub pwg, phab ntsa plab pem hauv ntej, pob tw nrawm nruj rau tib lub sijhawm, ib hnub ib zaug, hloov chaw txhaj tshuaj txhua hnub,
• Cov koob tshuaj thiab lub sijhawm ntawm cov thawj coj yog xaiv tus kheej los ntawm tus kws kho mob koom nrog, kev kho mob ntshav lossis noj tshuaj nrog rau lwm cov tshuaj muaj ntshav tsis zoo yog tso cai,
• Cov roj pleev txhaj tshuaj yuav tsum tsis txhob tov lossis sib xyaw nrog lwm cov tshuaj insulin,
• Lantus yuav tsum tsis txhob ua haujlwm koob tshuaj, qhov ua tau zoo tshaj plaws ntawm cov tshuaj yog manifested nrog subcutaneous tswj hwm,
• Thaum hloov mus rau Lantus los ntawm lwm cov tshuaj insulin, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo saib xyuas ntshav qib ntshav hauv thawj 2-3 lub lis piam.

Cov txheej txheem ntawm kev hloov pauv los ntawm lwm cov tshuaj hypoglycemic mus rau Lantus yuav tsum yog tus kws kho mob tau koom nrog cov txiaj ntsig ntawm kev kuaj mob, suav txog tus yam ntxwv ntawm tus neeg mob. Yav tom ntej, kev noj tshuaj ntau dua tuaj yeem hloov kho nrog kev nkag siab ntau ntxiv rau cov tshuaj insulin vim muaj kev txhim kho kev tswj ntawm cov metabolism.

Kev kho ntawm lub tswv yim kuj yuav xav tau thaum hloov txoj kev ua neej, kev ua neej, qhov hnyav ntawm tus neeg mob lossis lwm yam cuam tshuam uas ua rau muaj qhov nce siab ntxiv rau qhov mob ntshav siab- lossis ntshav qab zib tsawg.

Raws li cov lus qhia rau kev siv, insulin Lantus yog tshuaj rau:

1. mob ntshav qab zib insulin-hom mob ntshav qab zib hom (hom 1,)
2. non-insulin-daim ntawv foos ntawm tus kabmob (hom 2). Nws yog siv thaum cev xeeb tub, qhov tsis muaj txiaj ntsig ntawm qhov ncauj-txo cov tshuaj, muaj cov kab mob sib kis.

Cov lus qhia rau kev siv qhia tias cov tshuaj no muaj contraindicated:

1. thaum kev nkag siab ntawm lub cev mus rau cov tshuaj nquag lossis lwm yam ntxiv ntawm cov tshuaj ntxiv,
2. thaum kho ib tug menyuam yaus hnub nyoog qis dua 6 xyoo.

Hauv lub hlis ntawm cev xeeb tub, cov tshuaj yog coj raws li tus kws kho mob tshwj xeeb.

- mob ntshav qab zib mellitus xav tau cov tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj 6 xyoo.

Mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab menyuam yaus hnub nyoog ntau dua 2 xyoos.

ua kom lub siab tsis haum rau cov tshuaj insulin glargine lossis lwm yam kev pabcuam ntawm cov tshuaj,

cov menyuam yaus lub hnub nyoog txog 2 xyoos (tsis muaj cov ntaub ntawv hais txog kev siv).

Ceev faj: cov poj niam cev xeeb tub (muaj peev xwm hloov pauv tshuaj insulin thaum cev xeeb tub thiab tom qab yug menyuam).

Mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab cov menyuam yaus hnub nyoog tshaj 6 xyoo.

cov tshuaj tiv thaiv kab mob rau insulin glargine lossis rau ib qho ntawm cov neeg tsis sib haum,

cov menyuam yaus hnub nyoog qis dua 6 xyoo (tam sim no tsis muaj ntaub ntawv qhia txog kev siv).

Ceev faj yuav tsum siv rau hauv tus poj niam cev xeeb tub.

Insulin Lantus SoloStar yog siv rau cov ntshav qab zib ntawm ob hom hnub nyoog ntawm 6 xyoo.

Dab tsi yog cov contraindications rau kev siv tshuaj Lantus? Cov lus qhia rau kev siv cov tshuaj qhia pom ob pawg neeg ntawm cov neeg uas tau muab tshuaj rau contraindicated.

Tsis txhob siv cov tshuaj no rau hauv cov neeg mob uas ua xua nrog cov tshuaj nquag lossis ntxiv rau cov tshuaj ntxiv. Nov yog qhov tsuas yog contraindication rau kev siv tshuaj.

Nws yog tshuaj rau cov neeg mob ntawm endocrinologist uas raug kev txom nyem los ntawm ob hom ntshav qab zib. Feem ntau cov no yog cov neeg laus thiab menyuam yaus hnub nyoog li ntawm rau xyoo.

Nws tsis tuaj yeem raug kho rau cov neeg uas tsis mob siab rau rau cov khoom tseem ceeb thiab cov khoom siv ntxiv.

Lantus txwv tsis pub nqa mus rau cov neeg mob kev txom nyem los ntawm kev tso ntshav qab zib kom tsawg.

Txog kev kho mob rau menyuam yaus nrog cov tshuaj no, hauv kev kho menyuam yaus nws tuaj yeem siv los kho cov menyuam mos uas muaj hnub nyoog ntau dua ob xyoos.

Nws yog ib qho tseem ceeb kom nco ntsoov tias insulin glargine, uas yog ib feem ntawm Lantus, tsis yog ib yam khoom uas pab hauv kev kho mob ntshav qab zib ketoacidosis. Lwm lub ntsiab lus tseem ceeb yog hauv qab no: cov tshuaj yuav tsum tau siv nrog ceev faj rau cov neeg uas muaj kev phom sij thaum noj ntshav qis.

Nws yog txwv tsis pub siv insulin glargine rau cov neeg uas muaj kev fab tshuaj rau cov tshuaj no tshwm sim los ntawm kev tsis haum rau ib tug neeg. Kev siv ntawm Lantus Solostar raws li cov lus qhia los ntawm cov menyuam yaus hnub nyoog qis dua 6 xyoo yog txwv tsis pub siv. Nws tsuas yog siv los ntawm tus menyuam hlob dua. Cov tshuaj phiv:

• ntshav qab zib,
• tab kaum kev cuam tshuam,
• lub paj hlwb tsis ua hauj lwm zoo,
• kev ua xua ntawm daim tawv nqaij
• pom kev pom
• myalgia.

Cov kev mob tshwm sim rau cov tawv nqaij ua pob ua pob thiab khaus khaus pom nyob rau cov neeg tsis tau muaj hnub nyoog 18-20 xyoo, thiab tus neeg mob hnub nyoog laus dua li lub hnub nyoog tsis tshua muaj kev phiv los sis cov kev mob tshwm sim, feem ntau vim yog cov tib neeg cov yam ntxwv ntawm lub cev.

Kev mob ntshav qab zib yog ib yam ua rau cov ntshav qab zib tsawg, yog ib qho kev phiv rau cov neeg mob uas siv tshuaj insulin. Ntawm ib feem ntawm lub hauv nruab nrab lub paj hlwb, qhov ib txwm mloog zoo li qaug zog, txob taus, tsis nco qab thiab tsaug zog yuav tuaj yeem.

Tsaus muag thiab npaj ua ntej yuav tsaus muag yog ua tau, muaj qhov nquag hnov ​​ib qho ntawm xeev siab, mob taub hau, ntxhov siab los ntawm ib sab ntawm kev nco qab, tsis meej pem ntawm txoj kev xav.

Ua rau muaj tshuaj tiv thaiv kab mob glycemia, tus neeg mob yuav muaj lub siab nqhis dej tsis tu ncua, uas ua rau lub cev tsis muaj peev xwm tswj cov txheej txheem ntawm kev noj zaub mov. Cov tsos mob qog ua si, tawv nqaij daj, ua rau lub ntsej muag, tawm hws.

Cov tshuaj tiv thaiv tsis zoo rau ntawm feem ntawm cov tshuaj tiv thaiv kab mob yog ua pob rau ntawm daim tawv nqaij, muaj qhov pheej hmoo siab ntawm kev poob siab ntawm cov kab mob angioneurotic, bronchospasm. Daim duab cov tsos mob no tuaj yeem cuam tshuam rau cov neeg keeb kwm yav dhau los uas muaj cov kab mob ntev thiab ua kev hem thawj rau tus neeg mob lub neej.

Pom kev tsis zoo, raws li cov lus teb rau insulin, tsis tshua muaj tshwm sim.Pathology cuam tshuam nrog kev hloov pauv ntawm cov nqaij mos ntawm cov nqaij mos, uas yog ib ntus.

Tej zaum muaj kev ua txhaum ntawm tus txheej txheem ntawm kev ua kom rov qab zoo siab ntawm qhov muag teeb. Tsis tshua muaj txiaj ntsig, tab sis muaj feem tshwm sim ntawm Lantus yog myalgia - qhov mob ntawm qhov leeg mob hauv cov leeg.

Hauv thaj tsam ntawm kev tswj hwm tshuaj, ib qho tsos mob me me, liab thiab khaus, qhov mob me me kuj tshwm sim. Cov nqaij mos o qhuav muaj qhov tsawg.

Nrog rau kev siv tsis yog ntawm Lantus, ib qho kev siv ntau tshaj yog ua tau, uas tau hais tawm hauv kev mob hnyav ntawm glycemia. Yog tias tsis muaj kev kho mob raws sijhawm, qhov xwm txheej no tuaj yeem ua rau tuag tau. Cov tsos mob ntawm ib qho kev noj haus ntau dhau yog qhov ua tsis taus pa, muaj kev cuam tshuam ntawm lub hauv nruab nrab cov hlab hlwb, ib qho mob ceev ntawm glycemia, coma.

Cov tshuaj Insulin Lantus muaj cov nyhuv ntev ntev, txhim kho cov metabolism hauv cov piam thaj thiab tswj cov metabolism hauv kev ua kom rog. Thaum noj tshuaj, qab zib kom tsawg los ntawm cov nqaij thiab cov nqaij rog yog ceev. Tsis tas li, tus neeg sawv cev hormonal ua kom cov protein ntau. Tib lub sijhawm, proteolysis thiab lipolysis hauv adipocytes yog inhibited.

Kev siv tshuaj Insulin Lantus tsis yog qhov tsim nyog rau kev tsis txaus ntseeg rau cov tshuaj nquag lossis cov khoom siv pabcuam. Rau cov tub ntxhais hluas, cov tshuaj tau hais tawm tsuas yog thaum lawv muaj 16 xyoo.

Kev saib xyuas tshwj xeeb yuav tsum tau coj thaum tsim kev loj hlob ntawm cov hlab ntsha hlwb ntau dua, kom lub cev ntawm cov hlab ntshav thiab cov hlab ntsha. Kev tshuaj ntsuam mob kuj tseem ceeb rau cov neeg mob uas cov tsos mob ntawm lub qog ntshav qab zib. Tus kab mob no tuaj yeem raug npog los ntawm kev puas siab puas ntsws, leeg mob hlwb, ntshav qab zib ntev.

Raws li cov lus qhia nruj, nws yog tshuaj rau cov neeg laus. Tib yam siv rau cov neeg uas tau hloov los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg.

Raws li cov lus qhia Lantus yog contraindicated:

• Nrog rau kev nkag siab ntxiv rau cov tshuaj insulin glargine lossis rau ib ntu twg ntawm cov tshuaj tiv thaiv,
• Cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Cov poj niam cev xeeb tub yuav tsum tau siv nrog ceev faj, nyob rau hauv kev saib xyuas ntawm tus kws kho mob.

Kev cuam tshuam nrog lwm yam tshuaj

Muaj cov tshuaj uas cuam tshuam rau cov metabolism hauv cov metabolism, thaum nce los yog txo qis yuav tsum muaj cov insulin.

Txo cov piam thaj: cov tshuaj tiv thaiv kab mob hauv lub cev, sulfonamides, ACE inhibitors, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Qab zib kom ntau: cov thyroid hormones, diuretics, sympathomimetics, tshuaj tiv thaiv qhov ncauj, phenothiazine derivatives, protease inhibitors.

Qee yam tshuaj muaj ob qho ua kom tsis pom kev thiab qhov ua tsis zoo. Cov no suav nrog:

• beta blockers thiab ntsev lithium,
• cawv
• clonidine (antihypertensive tshuaj).

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Lantus tsim tawm los ntawm kev daws teeb meem rau kev tswj hwm subcutaneous: pob tshab, yuav luag tsis muaj xim lossis xim tsis muaj xim (3 ml txhua xim tsis muaj xim nyob rau hauv daim iav, 5 daim cartridges hauv cov hlwv pob, 1 ntim rau hauv pob ntawv cardboard, 5 OptiClick lub thawv hauv cov thawv sib dhos, 5 txhua OptiSet syringe mem hauv kab ntawv thawv).

Cov tshuaj muaj pes tsawg leeg 1 ml ntawm cov tshuaj muaj xws li:

• Cov tshuaj nquag: insulin glargine - 3.6378 mg (sib raug rau cov ntsiab lus ntawm tib neeg cov insulin - 100 PIECES),
• Ntu cov khoom siv: zinc chloride, metacresol (m-cresol), 85% glycerol, sodium hydroxide, hydrochloric acid, dej rau kev txhaj tshuaj.

Sab sij huam

Thaum kho, cov kev mob tshwm sim tom qab no tuaj yeem tsim:

• Musculoskeletal system: muaj tsawg heev - myalgia,
• Tej leeg hauv lub paj hlwb: tsis tshua muaj tshwm sim - dysgeusia,
• Lub cev ntawm lub zeem muag: tsis tshua pom - rov ua haujlwm, pom kev tsis hnov ​​lus. Nrog cov tshuaj insulin, nrog cov kev hloov pauv hauv cov ntshav qabzib cov ntshav qabzib, cov ntshav qab zib tau ua rau muaj kev tsis txaus siab ib ntus. Lub sijhawm ntev li niaj zaus ntawm cov ntshav qabzib yuav txo qhov kev pheej hmoo ntawm tus mob.Nyob rau hauv cov neeg mob nrog kev loj hlob retinopathy, ntu kev mob ntshav qab zib siab ntau tuaj yeem ua rau txhim kho qhov tsis pom kev tsis pom kev,
• Kev tiv thaiv kab mob: tsis tshua muaj - edema, sodium tuav,
• Cov tawv nqaij thiab cov roj ntsha subcutaneous: feem ntau - lipodystrophy thiab cov tshuaj insulin hauv zos ncua qeeb, ua tsis tiav - lipoatrophy. Txo qhov mob hnyav lossis tiv thaiv kev txhim kho lipoatrophy ua rau muaj qhov hloov chaw tas li ntawm cov chaw txhaj tshuaj hauv thaj chaw hauv lub cev uas tau pom zoo rau kev tswj hwm ntawm subulinaneous ntawm insulin,
• Cov tshuaj tiv thaiv hauv zos: feem ntau - hnov ​​mob, liab, khaus, urticaria, o lossis o rau ntawm thaj chaw txhaj tshuaj. Cov kev tsis haum siab feem ntau yog daws los ntawm ob peb hnub mus rau ob peb lub lis piam,
• Kev tsis haum tshuaj: tsis tshua muaj, kev tsis haum ntawm hom tam sim rau feem ntawm cov tshuaj, manifested li angioedema, kev poob siab, kev tawm tsam ntawm daim tawv nqaij dav dav, mob ntshav qis, bronchospasm (cov tshuaj tiv thaiv no tuaj yeem tsim kev hem thawj rau tus neeg mob lub neej). Qee qhov xwm txheej, thaum pom cov tshuaj tiv thaiv uas ua rau cov ntshav tiv thaiv tib neeg, nws yuav tsim nyog los kho lub koob tshuaj kom tshem tawm qhov mob siab rau qhov mob hyper- lossis hypoglycemia.

Tsis tas li, thaum siv Lantus, txoj kev txhim kho ntawm kev phiv cuam tshuam nrog kev cuam tshuam ntawm cov metabolism carbohydrate yog qhov ua tau. Feem ntau, cov ntshav qog ua ntshav nce siab yog tias cov koob tshuaj insulin ntau dua qhov xav tau. Kev rov ua dua ntawm cov ntshav qog ntshav qis tuaj yeem ua rau kev puas tsuaj rau cov hlab ntshav ntawm lub paj hlwb. Kev mob ntshav qis thiab mob ntshav qab zib ntev tuaj yeem hem ua rau lub neej ntawm cov neeg mob.

Tawm tsam cov keeb kwm yav dhau los ntawm hypoglycemia, nws muaj peev xwm tsim cov neuropsychiatric ntshawv siab (mob huam, "twilight" nco qab lossis nws poob), uas feem ntau ua ntej los ntawm cov cim ntawm adrenergic counter-kev cai raws li kev tshaib kev nqhis, txias hws, txob taus, tachycardia (qhov tseem ceeb thiab sai ntawm kev txhim kho hypoglycemia, qhov ntau tshaj tawm cov no cov tsos mob).

Daim ntawv qhia kev nyab xeeb rau cov neeg mob hnub nyoog qis dua 18 xyoo yog qhov zoo ib yam li daim qhia kev nyab xeeb rau cov neeg laus. Cov neeg mob hnub nyoog qis dua 18 xyoo yog qhov ntau dua ntawm cov tawv nqaij ua pob lossis khaus thiab ua xua hauv zos. Tsis muaj cov ntaub ntawv qhia txog kev nyab xeeb ntawm Lantus hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Cov lus qhia tshwj xeeb

Lantus yuav tsum tsis txhob siv rau hauv kev kho mob ntshav qab zib ketoacidosis (hauv qhov no, kev tso ntshav ntawm cov tshuaj insulin luv luv yog qhia).

Vim tias kev ua haujlwm nrog Lantus tsawg tsawg, nws tsis tuaj yeem txheeb xyuas nws qhov ua tau zoo thiab kev nyab xeeb hauv kev kho mob rau cov neeg mob lub siab ua haujlwm tsis txaus los yog cov neeg mob lub raum tsis ua haujlwm loj lossis qis qis.

Hauv cov neeg mob uas ua tsis zoo rau lub raum, qhov xav tau cov tshuaj insulin tuaj yeem txo qis vim qhov ua kom tsis muaj zog ntawm nws cov txheej txheem tshem tawm. Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum ua haujlwm tuaj yeem ua rau cov insulin txuas ntxiv kom tsawg.

Hauv cov neeg mob uas muaj kev tiv thaiv kabmob hepatic txaus, qhov kev xav tau rau cov tshuaj insulin yuav tsawg dua, uas cuam tshuam nrog txo qis kev muaj peev xwm biotransformation ntawm insulin thiab gluconeogenesis.

Nrog kev tswj tsis tau zoo tshaj theem ntawm cov piam thaj hauv cov ntshav, nrog rau kev muaj peev xwm ntawm kev loj hlob ntawm hyper- lossis hypoglycemia, ua ntej kho cov txheej txheem ntau npaum li cas, koj yuav tsum kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem tshuaj kho mob, chaw tswj hwm ntawm Lantus thiab cov txheej txheem ntawm kev txhaj tshuaj subcutaneous, coj mus rau hauv tus lej txhua yam cuam tshuam uas cuam tshuam rau qhov no. yam tseem ceeb.

Nrog rau kev txhim kho hypoglycemia hauv cov neeg mob uas tau txais Lantus, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv qhov muaj peev xwm ua kom qeeb ntawm qhov tawm ntawm lub xeev kev mob ntshav qab zib vim tias lub sijhawm ntev ntawm cov tshuaj.

Cov neeg mob hauv leej twg ntu kev kub siab ntawm lub qog ntshav qab zib muaj kev tshwj xeeb kho mob, suav nrog nrog kev mob hnyav ntawm cov hlab ntsha ntawm lub paj hlwb lossis mob hlab ntsha txhaws (muaj kev pheej hmoo ntawm cov hlab ntsha hlwb thiab lub plawv ntawm cov ntshav qog ntshav qab zib), nrog rau cov neeg mob qog ntshav siab, nws yog qhov yuav tsum tau ua tib zoo saib xyuas cov ntshav qabzib thiab saib xyuas kev tshwj xeeb.

Cov neeg mob yuav tsum tau ceeb toom ntawm cov xwm txheej uas cov tsos mob ntawm cov neeg mob hypoglycemia tsawg dua los yuav tsis hais tawm lossis tsis tuaj.Cov pab pawg muaj mob suav nrog cov neeg mob uas tau txhim kho txoj cai ntshav qabzib lossis ntshav qabzib ntau zuj zus, cov neeg mob neuropathy, mob ntshav qab zib ntev ntev, thiab mob hlwb tsis zoo. Cov tsos mob ntawm tus mob ntshav qab zib tsawg tej zaum kuj tsis tshua pom tseeb hauv cov neeg mob laus thiab cov neeg mob hloov pauv los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg los yog tau txais kev kho mob nrog lwm cov tshuaj. Hauv qhov xwm txheej no, mob ntshav qab zib siab heev (nrog rau qhov ua rau tsis nco qab) yuav tshwm sim ua ntej tus neeg mob pom tau tias nws tab tom muaj tus mob ntshav qab zib tsawg.

Txo txoj kev pheej hmoo ntawm hypoglycemia pab txhawb kom tus neeg mob ua raws li kev noj tshuaj, kev noj haus thiab kev noj zaub mov zoo, kev tswj hwm ntawm qhov pib ntawm cov tsos mob ntawm tus mob ntshav qab zib thiab siv tshuaj insulin kom raug. Thaum cov xwm txheej nce ntxiv qhov kev xav ua ntej rau kev txhim kho ntshav qab zib, tshwj xeeb tshaj yog saib xyuas tus neeg mob tus mob yuav tsum muaj, vim tias yuav tsum tau txhaj tshuaj insulin ntau dua. Tej yam no suav nrog:

• Hloov chaw ntawm cov thawj coj ntawm insulin,
• Kev haus dej haus cawv
• Neeg tsis siv sijhawm, ua haujlwm ntev lossis nce lub cev,
• Nce insulin rhiab heev (piv txwv li, thaum muaj kev ntxhov siab tshem tawm),
• Skipped noj mov
• Cov kab mob sib xyaw nrog kev zawv plab lossis ntuav,
• Ua txhaum ntawm kev noj haus thiab kev noj haus,
• Qee qhov ua haujlwm tsis pom tseeb ntawm endocrine (piv txwv, tsis txaus ntawm adrenal cortex lossis adenohypophysis, hypothyroidism),
• Kev qhia tseeb nrog qee yam tshuaj ntxiv.

Hauv cov kab mob sib cuam tshuam, yuav tsum muaj kev saib xyuas ntshav qab zib ntau dua. Feem ntau, yuav tsum tau tshawb xyuas seb puas muaj ketone lub cev nyob hauv cov zis, thiab kev noj tshuaj insulin kuj tseem xav tau kho. Feem ntau xav tau cov insulin ntau ntxiv. Cov neeg mob ntshav qab zib hom 1 yuav tsum tau txuas ntxiv kev noj zaub mov carbohydrates, tsawg kawg ntawm cov khoom me, txawm tias thaum noj tsawg lossis tsis muaj peev xwm noj, nrog rau ntuav. Cov neeg mob zoo li no yuav tsum tsis txhob txwv cov tshuaj insulin.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj tiv thaiv kab mob rau hauv lub cev, fluoxetine, angiotensin-hloov enzyme inhibitors, fibrates, disopyramide, dextropropoxyphene, pentoxifylline, salicylates thiab sulfanilamide antimicrobials tej zaum yuav tsum tau ntxiv cov tshuaj tiv thaiv hypoglycemia thiab insulin hypoglycemic, thiab antimicrob yuav tsum tau.

Cov thyroid hormones, diuretics, glucocorticosteroids, diazoxide, danazole, isoniazid, qee cov tshuaj tiv thaiv kab mob (xws li clozapine lossis olanzapine), glucagon, progestogens, estrogens, somatotropin, phenothiazine derivatives, sympathomoltamines (piv txwv li, sympathomoltamines) tuaj yeem txo qis. , protease inhibitors (hauv qhov no, yuav tsum tau txhaj tshuaj insulin).

Siv cov tshuaj insulin nrog pentamidine tib lub sijhawm tuaj yeem ua rau lub qog ntshav qab zib, uas tuaj yeem hloov los ntawm hyperglycemia. Nrog tib lub sijhawm siv Lantus nrog clonidine, beta-blockers, ethanol thiab lithium ntsev, ob qho tib si nce thiab txo qis hauv cov nyhuv hypoglycemic ntawm insulin yog ua tau.

Nrog tib lub sijhawm siv Lantus nrog cov tshuaj sympatholytic (clonidine, beta-blockers, guanfacin thiab reserpine) nrog kev txhim kho ntawm hypoglycemia, qhov txo qis lossis tsis muaj cov cim ntawm adrenergic counterregulation yog ua tau.

Daim roj pleev kab yuav tsum tsis txhob sib xyaw lossis yaj nrog lwm cov tshuaj insulin lossis nrog lwm yam tshuaj. Thaum diluted los yog sib xyaw, qhov profile ntawm nws qhov kev txiav txim hauv lub sijhawm yuav hloov. Nws tseem tuaj yeem ua rau cov nag lossis daus.

Cov lus thiab cov xwm txheej ntawm kev cia

Muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam yaus ntawm qhov kub ntawm 2-8 ° C, tsis txhob khov.

Txee lub neej yog 3 xyoos.

Tom qab pib siv cov khoom siv cartridges, OptiClick cartridge system thiab OptiSet pre-filled syringe pens yuav tsum tau muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam, ntawm qhov kub txog 25 ° C hauv lawv tus kheej lub thawv ntawv ntim.

Qhov ua kom dhau OptiSet koob txhaj tshuaj yuav tsum tsis txhob cia kom txias.

Daim ntawv tshaj tawm hnub tim nyob rau hauv daim cartridges, OptiClick cartridge system thiab ua ntej OptiSet syringe cwjmem tom qab siv thawj zaug - 1 hlis.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

3 ml cartridges thiab SoloStar syringe cwjmem

1 ml ntawm cov tshuaj muaj:

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), dej rau kev txhaj tshuaj.

1 ml ntawm cov tshuaj muaj:

cov tshuaj nquag: insulin glargine - 3.6378 mg, uas sib raug rau 100 PIECES ntawm tib neeg cov tshuaj insulin.

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), polysorbate 20, dej rau kev txhaj tshuaj.

Cov tshuaj insulin glargine tau los ntawm kev rov ua kom tiav ntawm cov kab mob DNA ntawm hom Escherichia coli.

ntshiab, tsis muaj kob.

Pharmacological kev txiav txim

Lantus yog ib hom tshuaj uas tsim los ntawm cov qauv tsim noob caj noob ces. Cov qauv ntawm cov qauv ntawm cov roj ntsha ntawm cov tshuaj insulin yog coj los ua lub hauv paus, tab sis muaj ntau cov amino acids hloov hauv nws, uas txiav txim siab cov yam ntxwv tshwj xeeb ntawm yeeb tshuaj. Kev daws ntawm cov tshuaj muaj ib qho nruab nrab acidic (pH 4), tom qab qhia rau hauv cov rog subcutaneous (alkaline nruab nrab), cov kua roj acidic cuam tshuam nrog kev tsim cov microprecipitate, los ntawm cov tshuaj insulin glargine me me maj mam tso tawm thiab nqus mus rau hauv cov ntshav. Qhov no qhia tau kom paub tseeb tseeb, du (tsis muaj peaks) kev ua haujlwm profile, ntxiv rau kev ua haujlwm ntev dua.

Glulin insulin yog metabolized los ua 2 lub zog metabolites - Ml thiab M2

Kev khi rau insulin-zoo li qhov kev loj hlob 1 (IGF-1) receptors hauv tib neeg. Hauv cov ntsiab lus hauv kev kho mob, nws yog ib qho tseem ceeb ntawm txoj kev khi ntawm cov tshuaj metabolites Ml thiab M2 tsim rau IGF-1 receptors tsim tam sim tom qab txhaj tshuaj rau hauv cov nqaij subcutaneous yog me ntsis qis dua li ntawm tib neeg cov insulin. Thaum kho nrog Lantus, kho cov tshuaj lom ntawm cov tshuaj insulin glargine thiab nws cov metabolites yog qhov qis dua li cov tshuaj muaj zog uas yuav tsum tau ua kom muaj kev tiv thaiv kab mob mitogen-proliferative triggered los ntawm physiologically muaj IGF-1 hauv lub cev.

Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib hauv ntau txoj kev:

Txhim cov piam thaj kev nkag los ntawm cov ntaub so ntswg (tshwj xeeb tshaj yog cov leeg pob txha thiab cov nqaij mos),

Txwv tsis pub tsim muaj cov piam thaj hauv lub siab (gluconeogenesis).

Cov kua dej los tiv thaiv kev rhuav tshem cov lipids hauv adipose cov nqaij mos, nrog rau cov txheej txheem ntawm cov protein tawg, thaum txhim kho cov txheej txheem ntawm cov protein tsim hauv cov plab hnyuv siab raum thiab cov nqaij mos.

Hauv kev sib piv ntawm kev tshawb fawb ntawm normoglycemia nrog kev sib ntxiv los ntawm cov tshuaj tiv thaiv NPH insulin hauv cov neeg ua haujlwm noj qab haus huv thiab cov neeg mob uas muaj ntshav qab zib hom ntshav qab zib, qhov kev ua ntawm insulin glargine nrog kev tswj hwm tau tsim kho qeeb dua, thiab cov haujlwm kev ua tau zoo txawm tias, "zoo kawg", lub sijhawm ua haujlwm tau ntev dua.

Daim duab qhia hauv qab no qhia txog cov txiaj ntsig ntawm kev kawm txog cov kev ua ub no ntawm insulin glargine thiab NPH-insulin hauv cov neeg mob ntshav qab zib hom 1.

Ntev ntev ntawm kev ua ntawm insulin

thov cov tshuaj ib hnub ib zaug. Tom qab subcutaneous tswj hwm, qhov pib ntawm kev ua

tshwm sim, nyob rau nruab nrab, tom qab 1 teev. Lub sijhawm nruab nrab ntawm kev nqis tes yog 24

teev, siab kawg - 29 teev. Pib lub sijhawm thiab sijhawm ua haujlwm ntawm insulin thiab

nws cov analogues, xws li insulin glargine, tuaj yeem sib txawv ntawm cov sib txawv

cov neeg mob lossis hauv tib tus neeg mob.

Cov kev tshawb fawb soj ntsuam thiab pharmacological tau qhia tias ntawm tib lub sijhawm, insulin glargine thiab tib neeg insulin muaj txiaj ntsig zoo ib yam, thiab cov tsos mob ntawm hypoglycemia lossis cov lus teb hormonal ntawm counterregulation tau zoo ib yam. Thaum muab piv rau Lantus nrog NPH-insulin, nws tsis muaj qhov sib txawv ntawm qhov muaj tshwm sim ntawm tus mob ntshav qab zib retinopathy (qhib 5 xyoo, NPH-tswj cov chaw kuaj mob).

Kev siv cov tshuaj ib hnub ib zaug thaum yuav mus pw nyob rau hauv cov neeg no ntawm cov neeg mob ntshav qab zib hom 1 tau kawm nyob rau ntau pab pawg hnub nyoog hauv kev sib tw, tswj kev soj ntsuam:

Cov menyuam yaus hnub nyoog 6 txog 15 xyoo (n = 349) rau 28 lub lis piam, tom qab ntawd txuas ntxiv ntawm 143 cov neeg mob kho insulin glargine nyob rau hauv kev kawm tsis tau txuas ntxiv nrog kev soj ntsuam lub sijhawm 2 xyoo ntawm qhov nruab nrab.

Kev tshawb nrhiav ntu hauv 26 ntawm cov tub ntxhais hluas hnub nyoog 12 txog 18 xyoo (dhau 16 lub lis piam).

Hauv cov menyuam hnub nyoog 2 txog 6 xyoo (n = 125), kev tshawb nrhiav 24-lub lim tiam tau tshawb pom hauv cov pab pawg sib luag (piv nrog insulin NPH).

Cov kev tshawb fawb pom tsis muaj kev hem thawj tshiab rau kev nyab xeeb rau cov neeg mob.

Cov Yuav Tsum Muaj

• Lub hnub nyoog txog 6 xyoo (tsis muaj ntaub ntawv txaus ntseeg txog qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv Lantus hauv pawg hnub nyoog ntawm cov neeg mob),
• Hypersensitivity rau cov tshuaj.

Cov poj niam cev xeeb tub yuav tsum siv cov Lantus nrog kev ceev faj.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Lantus thiab lub sijhawm ntawm hnub rau nws cov kev tswj hwm tau teeb tsa ua ib leeg zuj zus.

Cov tshuaj yuav tsum tau muab tshuaj subcutaneously (hauv roj subcutaneous ntawm lub xub pwg, plab los yog ncej puab) 1 ib zaug hauv ib hnub ib txwm tib lub sijhawm. Cov chaw txhaj tshuaj yuav tsum tau hloov nrog txhua tus tswj hwm Lantus tshiab hauv thaj chaw pom zoo rau kev tswj hwm.

Tej zaum siv cov Lantus ua cov tshuaj monotherapy lossis ib txhij nrog lwm cov tshuaj hypoglycemic.

Thaum hloov cov neeg mob nrog nruab nrab ntev lossis ntev ntev los ua cov insulins rau Lantus, nws yuav tsim nyog hloov pauv cov tshuaj tiv thaiv kab mob tiv thaiv kab mob (tshuaj ntawm qhov ncauj hypoglycemic, nrog rau kev tswj hwm kev noj tshuaj thiab kev noj tshuaj insulins luv luv lossis lawv cov analogues) lossis los kho cov tshuaj txhua hnub ntawm cov tshuaj insal basal.

Thaum hloov cov neeg mob los ntawm kev tswj hwm ob npaug ntawm insulin-isofan rau thawj tswj hwm Lantus hauv thawj lub lim tiam ntawm kev kho mob, nws yog qhov yuav tsum tau txo cov tshuaj txhua hnub ntawm cov tshuaj insal nyob rau 20-30% (txhawm rau txo qhov kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab thaum sawv ntxov ntxov). Rau lub sijhawm no, qhov txo qis ntawm lub koob ntawm Lantus yuav tsum tau them nyiaj rau los ntawm kev nce ntxiv ntawm cov koob tshuaj tiv thaiv luv luv ntawm kev ua haujlwm thiab kev noj tshuaj rau lub cev yuav tsum tau kho ntxiv.

Thaum lub sijhawm hloov mus rau Lantus thiab hauv thawj lub lis piam tom qab no, yuav tsum tau saib xyuas kev ua kom qabzib hauv cov ntshav. Yog tias tsim nyog, kho qhov tsuas tshuaj ntau dua ntawm cov tshuaj insulin. Kev hloov kho koob tshuaj kuj tseem xav tau rau lwm qhov laj thawj, piv txwv li, thaum hloov tus neeg mob txoj kev ua neej thiab lub cev qhov hnyav, lub sijhawm hnub ntawm kev tswj hwm tshuaj, los yog lwm qhov xwm txheej uas ua rau muaj kev cuam tshuam rau kev loj hlob ntawm hyper- lossis ntshav qab zib tsawg.

Cov tshuaj yuav tsum tsis txhob muab tshuaj rau qhov ntswg (mob ntshav qab zib tsawg heev yuav ua mob hnyav). Ua ntej pib cov lus qhia, koj yuav tsum paub tseeb tias cov koob txhaj tshuaj tsis muaj qhov seem ntawm lwm cov tshuaj.

Ua ntej siv OptiSet ua ntej puv syringe cwjmem, koj yuav tsum paub tseeb tias cov kev daws teeb meem tsis muaj xim, pob tshab, zoo li cov dej hauv kev ntxhib los mos thiab tsis muaj cov khoom pom. Tsuas yog cov koob txhaj rau OptiSet koob txhaj tshuaj siv tau. Txhawm rau tiv thaiv kev kis mob, tsuas yog ib tus neeg yuav tsum siv koob txhaj tshuaj ntxiv.

Sab sij huam

Thaum kho, cov kev mob tshwm sim tom qab no tuaj yeem tsim:

• Musculoskeletal system: muaj tsawg heev - myalgia,
• Tej leeg hauv lub paj hlwb: tsis tshua muaj tshwm sim - dysgeusia,
• Lub cev ntawm lub zeem muag: tsis tshua pom - rov ua haujlwm, pom kev tsis hnov ​​lus. Nrog cov tshuaj insulin, nrog cov kev hloov pauv hauv cov ntshav qabzib cov ntshav qabzib, cov ntshav qab zib tau ua rau muaj kev tsis txaus siab ib ntus. Lub sijhawm ntev li niaj zaus ntawm cov ntshav qabzib yuav txo qhov kev pheej hmoo ntawm tus mob. Nyob rau hauv cov neeg mob nrog kev loj hlob retinopathy, ntu kev mob ntshav qab zib siab ntau tuaj yeem ua rau txhim kho qhov tsis pom kev tsis pom kev,
• Kev tiv thaiv kab mob: tsis tshua muaj - edema, sodium tuav,
• Cov tawv nqaij thiab cov roj ntsha subcutaneous: feem ntau - lipodystrophy thiab cov tshuaj insulin hauv zos ncua qeeb, ua tsis tiav - lipoatrophy. Txo qhov mob hnyav lossis tiv thaiv kev txhim kho lipoatrophy ua rau muaj qhov hloov chaw tas li ntawm cov chaw txhaj tshuaj hauv thaj chaw hauv lub cev uas tau pom zoo rau kev tswj hwm ntawm subulinaneous ntawm insulin,
• Cov tshuaj tiv thaiv hauv zos: feem ntau - hnov ​​mob, liab, khaus, urticaria, o lossis o rau ntawm thaj chaw txhaj tshuaj. Cov kev tsis haum siab feem ntau yog daws los ntawm ob peb hnub mus rau ob peb lub lis piam,
• Kev tsis haum tshuaj: tsis tshua muaj, kev tsis haum ntawm hom tam sim rau feem ntawm cov tshuaj, manifested li angioedema, kev poob siab, kev tawm tsam ntawm daim tawv nqaij dav dav, mob ntshav qis, bronchospasm (cov tshuaj tiv thaiv no tuaj yeem tsim kev hem thawj rau tus neeg mob lub neej). Qee qhov xwm txheej, thaum pom cov tshuaj tiv thaiv uas ua rau cov ntshav tiv thaiv tib neeg, nws yuav tsim nyog los kho lub koob tshuaj kom tshem tawm qhov mob siab rau qhov mob hyper- lossis hypoglycemia.

Tsis tas li, thaum siv Lantus, txoj kev txhim kho ntawm kev phiv cuam tshuam nrog kev cuam tshuam ntawm cov metabolism carbohydrate yog qhov ua tau. Feem ntau, cov ntshav qog ua ntshav nce siab yog tias cov koob tshuaj insulin ntau dua qhov xav tau. Kev rov ua dua ntawm cov ntshav qog ntshav qis tuaj yeem ua rau kev puas tsuaj rau cov hlab ntshav ntawm lub paj hlwb. Kev mob ntshav qis thiab mob ntshav qab zib ntev tuaj yeem hem ua rau lub neej ntawm cov neeg mob.

Tawm tsam cov keeb kwm yav dhau los ntawm hypoglycemia, nws muaj peev xwm tsim cov neuropsychiatric ntshawv siab (mob huam, "twilight" nco qab lossis nws poob), uas feem ntau ua ntej los ntawm cov cim ntawm adrenergic counter-kev cai raws li kev tshaib kev nqhis, txias hws, txob taus, tachycardia (qhov tseem ceeb thiab sai ntawm kev txhim kho hypoglycemia, qhov ntau tshaj tawm cov no cov tsos mob).

Daim ntawv qhia kev nyab xeeb rau cov neeg mob hnub nyoog qis dua 18 xyoo yog qhov zoo ib yam li daim qhia kev nyab xeeb rau cov neeg laus. Cov neeg mob hnub nyoog qis dua 18 xyoo yog qhov ntau dua ntawm cov tawv nqaij ua pob lossis khaus thiab ua xua hauv zos. Tsis muaj cov ntaub ntawv qhia txog kev nyab xeeb ntawm Lantus hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Cov lus qhia tshwj xeeb

Lantus yuav tsum tsis txhob siv rau hauv kev kho mob ntshav qab zib ketoacidosis (hauv qhov no, kev tso ntshav ntawm cov tshuaj insulin luv luv yog qhia).

Vim tias kev ua haujlwm nrog Lantus tsawg tsawg, nws tsis tuaj yeem txheeb xyuas nws qhov ua tau zoo thiab kev nyab xeeb hauv kev kho mob rau cov neeg mob lub siab ua haujlwm tsis txaus los yog cov neeg mob lub raum tsis ua haujlwm loj lossis qis qis.

Hauv cov neeg mob uas ua tsis zoo rau lub raum, qhov xav tau cov tshuaj insulin tuaj yeem txo qis vim qhov ua kom tsis muaj zog ntawm nws cov txheej txheem tshem tawm. Hauv cov neeg laus neeg laus, kev ploj zuj zus hauv lub raum ua haujlwm tuaj yeem ua rau cov insulin txuas ntxiv kom tsawg.

Hauv cov neeg mob uas muaj kev tiv thaiv kabmob hepatic txaus, qhov kev xav tau rau cov tshuaj insulin yuav tsawg dua, uas cuam tshuam nrog txo qis kev muaj peev xwm biotransformation ntawm insulin thiab gluconeogenesis.

Nrog kev tswj tsis tau zoo tshaj theem ntawm cov piam thaj hauv cov ntshav, nrog rau kev muaj peev xwm ntawm kev loj hlob ntawm hyper- lossis hypoglycemia, ua ntej kho cov txheej txheem ntau npaum li cas, koj yuav tsum kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem tshuaj kho mob, chaw tswj hwm ntawm Lantus thiab cov txheej txheem ntawm kev txhaj tshuaj subcutaneous, coj mus rau hauv tus lej txhua yam cuam tshuam uas cuam tshuam rau qhov no. yam tseem ceeb.

Nrog rau kev txhim kho hypoglycemia hauv cov neeg mob uas tau txais Lantus, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv qhov muaj peev xwm ua kom qeeb ntawm qhov tawm ntawm lub xeev kev mob ntshav qab zib vim tias lub sijhawm ntev ntawm cov tshuaj.

Cov neeg mob hauv leej twg ntu kev kub siab ntawm lub qog ntshav qab zib muaj kev tshwj xeeb kho mob, suav nrog nrog kev mob hnyav ntawm cov hlab ntsha ntawm lub paj hlwb lossis mob hlab ntsha txhaws (muaj kev pheej hmoo ntawm cov hlab ntsha hlwb thiab lub plawv ntawm cov ntshav qog ntshav qab zib), nrog rau cov neeg mob qog ntshav siab, nws yog qhov yuav tsum tau ua tib zoo saib xyuas cov ntshav qabzib thiab saib xyuas kev tshwj xeeb.

Cov neeg mob yuav tsum tau ceeb toom ntawm cov xwm txheej uas cov tsos mob ntawm cov neeg mob hypoglycemia tsawg dua los yuav tsis hais tawm lossis tsis tuaj. Cov pab pawg muaj mob suav nrog cov neeg mob uas tau txhim kho txoj cai ntshav qabzib lossis ntshav qabzib ntau zuj zus, cov neeg mob neuropathy, mob ntshav qab zib ntev ntev, thiab mob hlwb tsis zoo. Cov tsos mob ntawm tus mob ntshav qab zib tsawg tej zaum kuj tsis tshua pom tseeb hauv cov neeg mob laus thiab cov neeg mob hloov pauv los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg los yog tau txais kev kho mob nrog lwm cov tshuaj. Hauv qhov xwm txheej no, mob ntshav qab zib siab heev (nrog rau qhov ua rau tsis nco qab) yuav tshwm sim ua ntej tus neeg mob pom tau tias nws tab tom muaj tus mob ntshav qab zib tsawg.

Txo txoj kev pheej hmoo ntawm hypoglycemia pab txhawb kom tus neeg mob ua raws li kev noj tshuaj, kev noj haus thiab kev noj zaub mov zoo, kev tswj hwm ntawm qhov pib ntawm cov tsos mob ntawm tus mob ntshav qab zib thiab siv tshuaj insulin kom raug. Thaum cov xwm txheej nce ntxiv qhov kev xav ua ntej rau kev txhim kho ntshav qab zib, tshwj xeeb tshaj yog saib xyuas tus neeg mob tus mob yuav tsum muaj, vim tias yuav tsum tau txhaj tshuaj insulin ntau dua. Tej yam no suav nrog:

• Hloov chaw ntawm cov thawj coj ntawm insulin,
• Kev haus dej haus cawv
• Neeg tsis siv sijhawm, ua haujlwm ntev lossis nce lub cev,
• Nce insulin rhiab heev (piv txwv li, thaum muaj kev ntxhov siab tshem tawm),
• Skipped noj mov
• Cov kab mob sib xyaw nrog kev zawv plab lossis ntuav,
• Ua txhaum ntawm kev noj haus thiab kev noj haus,
• Qee qhov ua haujlwm tsis pom tseeb ntawm endocrine (piv txwv, tsis txaus ntawm adrenal cortex lossis adenohypophysis, hypothyroidism),
• Kev qhia tseeb nrog qee yam tshuaj ntxiv.

Hauv cov kab mob sib cuam tshuam, yuav tsum muaj kev saib xyuas ntshav qab zib ntau dua. Feem ntau, yuav tsum tau tshawb xyuas seb puas muaj ketone lub cev nyob hauv cov zis, thiab kev noj tshuaj insulin kuj tseem xav tau kho. Feem ntau xav tau cov insulin ntau ntxiv. Cov neeg mob ntshav qab zib hom 1 yuav tsum tau txuas ntxiv kev noj zaub mov carbohydrates, tsawg kawg ntawm cov khoom me, txawm tias thaum noj tsawg lossis tsis muaj peev xwm noj, nrog rau ntuav. Cov neeg mob zoo li no yuav tsum tsis txhob txwv cov tshuaj insulin.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj tiv thaiv kab mob rau hauv lub cev, fluoxetine, angiotensin-hloov enzyme inhibitors, fibrates, disopyramide, dextropropoxyphene, pentoxifylline, salicylates thiab sulfanilamide antimicrobials tej zaum yuav tsum tau ntxiv cov tshuaj tiv thaiv hypoglycemia thiab insulin hypoglycemic, thiab antimicrob yuav tsum tau.

Cov thyroid hormones, diuretics, glucocorticosteroids, diazoxide, danazole, isoniazid, qee cov tshuaj tiv thaiv kab mob (xws li clozapine lossis olanzapine), glucagon, progestogens, estrogens, somatotropin, phenothiazine derivatives, sympathomoltamines (piv txwv li, sympathomoltamines) tuaj yeem txo qis. , protease inhibitors (hauv qhov no, yuav tsum tau txhaj tshuaj insulin).

Siv cov tshuaj insulin nrog pentamidine tib lub sijhawm tuaj yeem ua rau lub qog ntshav qab zib, uas tuaj yeem hloov los ntawm hyperglycemia.Nrog tib lub sijhawm siv Lantus nrog clonidine, beta-blockers, ethanol thiab lithium ntsev, ob qho tib si nce thiab txo qis hauv cov nyhuv hypoglycemic ntawm insulin yog ua tau.

Nrog tib lub sijhawm siv Lantus nrog cov tshuaj sympatholytic (clonidine, beta-blockers, guanfacin thiab reserpine) nrog kev txhim kho ntawm hypoglycemia, qhov txo qis lossis tsis muaj cov cim ntawm adrenergic counterregulation yog ua tau.

Daim roj pleev kab yuav tsum tsis txhob sib xyaw lossis yaj nrog lwm cov tshuaj insulin lossis nrog lwm yam tshuaj. Thaum diluted los yog sib xyaw, qhov profile ntawm nws qhov kev txiav txim hauv lub sijhawm yuav hloov. Nws tseem tuaj yeem ua rau cov nag lossis daus.

Cov lus thiab cov xwm txheej ntawm kev cia

Muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam yaus ntawm qhov kub ntawm 2-8 ° C, tsis txhob khov.

Txee lub neej yog 3 xyoos.

Tom qab pib siv cov khoom siv cartridges, OptiClick cartridge system thiab OptiSet pre-filled syringe pens yuav tsum tau muab cia rau hauv qhov chaw tsaus, tawm ntawm qhov chaw ncav cuag ntawm cov menyuam, ntawm qhov kub txog 25 ° C hauv lawv tus kheej lub thawv ntawv ntim.

Qhov ua kom dhau OptiSet koob txhaj tshuaj yuav tsum tsis txhob cia kom txias.

Daim ntawv tshaj tawm hnub tim nyob rau hauv daim cartridges, OptiClick cartridge system thiab ua ntej OptiSet syringe cwjmem tom qab siv thawj zaug - 1 hlis.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

3 ml cartridges thiab SoloStar syringe cwjmem

1 ml ntawm cov tshuaj muaj:

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), dej rau kev txhaj tshuaj.

1 ml ntawm cov tshuaj muaj:

cov tshuaj nquag: insulin glargine - 3.6378 mg, uas sib raug rau 100 PIECES ntawm tib neeg cov tshuaj insulin.

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), polysorbate 20, dej rau kev txhaj tshuaj.

Cov tshuaj insulin glargine tau los ntawm kev rov ua kom tiav ntawm cov kab mob DNA ntawm hom Escherichia coli.

ntshiab, tsis muaj kob.

Pharmacological kev txiav txim

Lantus yog ib hom tshuaj uas tsim los ntawm cov qauv tsim noob caj noob ces. Cov qauv ntawm cov qauv ntawm cov roj ntsha ntawm cov tshuaj insulin yog coj los ua lub hauv paus, tab sis muaj ntau cov amino acids hloov hauv nws, uas txiav txim siab cov yam ntxwv tshwj xeeb ntawm yeeb tshuaj. Kev daws ntawm cov tshuaj muaj ib qho nruab nrab acidic (pH 4), tom qab qhia rau hauv cov rog subcutaneous (alkaline nruab nrab), cov kua roj acidic cuam tshuam nrog kev tsim cov microprecipitate, los ntawm cov tshuaj insulin glargine me me maj mam tso tawm thiab nqus mus rau hauv cov ntshav. Qhov no qhia tau kom paub tseeb tseeb, du (tsis muaj peaks) kev ua haujlwm profile, ntxiv rau kev ua haujlwm ntev dua.

Glulin insulin yog metabolized los ua 2 lub zog metabolites - Ml thiab M2

Kev khi rau insulin-zoo li qhov kev loj hlob 1 (IGF-1) receptors hauv tib neeg. Hauv cov ntsiab lus hauv kev kho mob, nws yog ib qho tseem ceeb ntawm txoj kev khi ntawm cov tshuaj metabolites Ml thiab M2 tsim rau IGF-1 receptors tsim tam sim tom qab txhaj tshuaj rau hauv cov nqaij subcutaneous yog me ntsis qis dua li ntawm tib neeg cov insulin. Thaum kho nrog Lantus, kho cov tshuaj lom ntawm cov tshuaj insulin glargine thiab nws cov metabolites yog qhov qis dua li cov tshuaj muaj zog uas yuav tsum tau ua kom muaj kev tiv thaiv kab mob mitogen-proliferative triggered los ntawm physiologically muaj IGF-1 hauv lub cev.

Cov tshuaj Insulin thiab nws cov tshuaj noj kuj txo cov ntshav qabzib hauv ntau txoj kev:

Txhim cov piam thaj kev nkag los ntawm cov ntaub so ntswg (tshwj xeeb tshaj yog cov leeg pob txha thiab cov nqaij mos),

Txwv tsis pub tsim muaj cov piam thaj hauv lub siab (gluconeogenesis).

Cov kua dej los tiv thaiv kev rhuav tshem cov lipids hauv adipose cov nqaij mos, nrog rau cov txheej txheem ntawm cov protein tawg, thaum txhim kho cov txheej txheem ntawm cov protein tsim hauv cov plab hnyuv siab raum thiab cov nqaij mos.

Hauv kev sib piv ntawm kev tshawb fawb ntawm normoglycemia nrog kev sib ntxiv los ntawm cov tshuaj tiv thaiv NPH insulin hauv cov neeg ua haujlwm noj qab haus huv thiab cov neeg mob uas muaj ntshav qab zib hom ntshav qab zib, qhov kev ua ntawm insulin glargine nrog kev tswj hwm tau tsim kho qeeb dua, thiab cov haujlwm kev ua tau zoo txawm tias, "zoo kawg", lub sijhawm ua haujlwm tau ntev dua.

Daim duab qhia hauv qab no qhia txog cov txiaj ntsig ntawm kev kawm txog cov kev ua ub no ntawm insulin glargine thiab NPH-insulin hauv cov neeg mob ntshav qab zib hom 1.

Ntev ntev ntawm kev ua ntawm insulin

thov cov tshuaj ib hnub ib zaug. Tom qab subcutaneous tswj hwm, qhov pib ntawm kev ua

tshwm sim, nyob rau nruab nrab, tom qab 1 teev. Lub sijhawm nruab nrab ntawm kev nqis tes yog 24

teev, siab kawg - 29 teev. Pib lub sijhawm thiab sijhawm ua haujlwm ntawm insulin thiab

nws cov analogues, xws li insulin glargine, tuaj yeem sib txawv ntawm cov sib txawv

cov neeg mob lossis hauv tib tus neeg mob.

Cov kev tshawb fawb soj ntsuam thiab pharmacological tau qhia tias ntawm tib lub sijhawm, insulin glargine thiab tib neeg insulin muaj txiaj ntsig zoo ib yam, thiab cov tsos mob ntawm hypoglycemia lossis cov lus teb hormonal ntawm counterregulation tau zoo ib yam. Thaum muab piv rau Lantus nrog NPH-insulin, nws tsis muaj qhov sib txawv ntawm qhov muaj tshwm sim ntawm tus mob ntshav qab zib retinopathy (qhib 5 xyoo, NPH-tswj cov chaw kuaj mob).

Kev siv cov tshuaj ib hnub ib zaug thaum yuav mus pw nyob rau hauv cov neeg no ntawm cov neeg mob ntshav qab zib hom 1 tau kawm nyob rau ntau pab pawg hnub nyoog hauv kev sib tw, tswj kev soj ntsuam:

Cov menyuam yaus hnub nyoog 6 txog 15 xyoo (n = 349) rau 28 lub lis piam, tom qab ntawd txuas ntxiv ntawm 143 cov neeg mob kho insulin glargine nyob rau hauv kev kawm tsis tau txuas ntxiv nrog kev soj ntsuam lub sijhawm 2 xyoo ntawm qhov nruab nrab.

Kev tshawb nrhiav ntu hauv 26 ntawm cov tub ntxhais hluas hnub nyoog 12 txog 18 xyoo (dhau 16 lub lis piam).

Hauv cov menyuam hnub nyoog 2 txog 6 xyoo (n = 125), kev tshawb nrhiav 24-lub lim tiam tau tshawb pom hauv cov pab pawg sib luag (piv nrog insulin NPH).

Cov kev tshawb fawb pom tsis muaj kev hem thawj tshiab rau kev nyab xeeb rau cov neeg mob.

Cov Tshuaj Pharmacokinetics

Kev sib piv kev kawm txog cov ntsiab lus ntawm cov tshuaj insulin glargine thiab NPH-insulin hauv ntshav cov ntshav hauv cov neeg muaj mob thiab cov neeg mob ntshav qab zib mellitus tom qab cov tshuaj subcutaneous tshuaj tau qhia qeeb dua thiab ntev dua nqus los ntawm subcutaneous cov ntaub so ntswg, nrog rau qhov tsis muaj lub siab tshaj plaws hauv plasma concentration hauv insulin glargine piv rau NPH-insulin (saib kab ntsuas hauv ntu Pharmacodynamics). Qhov tsis muaj qhov ua siab tshaj ntawm kev nqis tes ua hauv Lantus muab qhov txiaj ntsig tseem ceeb hauv kev kho mob uas thaum nws siv, kev pheej hmoo ntawm kev txhim kho hypoglycemia yog tsawg dua lossis tsis txhua.

Nrog txoj kev txhaj ib leeg ntawm Lantus ib hnub ib zaug, qhov nruab nrab ruaj khov ntawm cov tshuaj insulin glargine hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug.

Tom qab subcutaneous txhaj ntawm Lantus hauv cov neeg mob ntshav qab zib mellitus, insulin glargine yog sai metabolized los ua ob lub cev nquag, Ml (21-A-glycyl-insulin) thiab M2 (21A-glycyl-des-30B-threonyl-insulin). Lub ntsiab metabolite ncig hauv cov ntshav hauv ntshav yog Ml. Plasma Ml siab zuj zus nrog qhov nce ntxiv ntawm cov koob tshuaj me me ntawm Lantus. Cov txiaj ntsig ntawm pharmacokinetic thiab pharmacodynamic cov kev tshawb fawb qhia tias cov nyhuv ntawm subcutaneous kev txhaj tshuaj ntawm Lantus feem ntau yog muab los ntawm metabolite Ml thiab nyob ntawm nws qhov kev mob siab hauv cov ntshav cov ntshav. Hauv feem coob ntawm cov neeg mob, insulin glargine thiab metabolite M2 tsis raug kuaj pom hauv cov ntshav ntshav, thiab yog tias kuaj tau, lawv qhov kev tsom tsis tau nyob ntawm kev siv cov tshuaj Lantus.

Cov tshuaj pharmacokinetics hauv cov menyuam yaus uas muaj hom 1 mob ntshav qab zib mellitus txij thaum muaj hnub nyoog 2 mus rau 6 xyoo raug soj ntsuam hauv ib qhov kev tshawb fawb soj ntsuam (saib Pharmacodynamics).Hauv cov menyuam yaus tau txais cov tshuaj insulin glargine, qhov tsawg kawg nkaus ntawm cov tshuaj insulin glargine thiab nws lub ntsiab metabolites M thiab M2 hauv cov ntshav tau raug ntsuas; vim li ntawd, nws tau pom tias qhov xwm ntawm kev hloov pauv hauv kev xav hauv cov menyuam yaus yog qhov zoo sib xws ntawm kev hloov pauv ntau hauv cov neeg laus, uas tsis muaj cov cim ntawm tsub zuj zuj ntawm insulin glargine lossis nws cov khoom siv tshuaj tiv thaiv nrog kev siv lub sijhawm ntev.

Kev ntsuas rau siv

Mob ntshav qab zib mellitus xav tau kev kho tshuaj insulin rau cov laus, cov hluas thiab menyuam yaus hnub nyoog ntau dua 2 xyoos.

Cov Yuav Tsum Muaj

Hypersensitivity rau cov nquag yam tshuaj los yog rau ib yam ntawm cov excipients.

Cev xeeb tub thiab lactation

Cov ntaub ntawv kho mob hais txog kev siv tshuaj insulin glargine rau cov poj niam cev xeeb tub, tau txais thaum tswj kev soj ntsuam, tsis tuaj. Txwv tsawg
cev xeeb tub, nrog rau lub xeev ntawm kev noj qab haus huv ntawm lub cev xeeb tub thiab cov menyuam tshiab. Tam sim no tsis muaj lwm cov ntaub ntawv tseem ceeb txog kabmob sib kis.

Rau cov neeg mob uas muaj ntshav qab zib yav dhau los los yog mob ntshav qab zib hauv lub cev, nws yog ib qho tseem ceeb kom muaj kev tswj hwm kev mob ntshav qab zib thoob plaws hauv lub cev xeeb tub. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab, feem ntau, nce ntxiv thaum txiav thib ob thiab peb feem plaub. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, yuav tsum tau saib xyuas kev ntshav qabzib kom zoo.

Kuj tsis paub meej tias insulin glargine kis mus rau niam mis tau licas. Tsis muaj teebmeem hauv metabolic thaum noj insulin glargine hauv tus menyuam mos tsis tau xav txog, txij li, yog cov protein, insulin glargine tau tawg rau hauv cov amino acids hauv tib neeg lub plab zom mov.

Hauv kev ua poj niam mis, nws yuav tsim nyog kho qhov tshuaj ntau npaum li cas ntawm cov tshuaj insulin thiab kev noj haus.

Sab sij huam

Yog tias muaj cov tsos mob zoo ib yam li cov lus tau hais hauv qab no, thov hu rau koj tus kws kho mob tam sim ntawd!

Kev mob ntshav qab zib tsawg tshaj, feem ntau tshaj qhov tsis xav tau ntawm kev kho mob insulin, tuaj yeem tshwm sim yog tias qhov koob tshuaj insulin ntau dhau piv rau qhov xav tau.

Cov kev tshwm sim tsis zoo hauv qab no los cuam tshuam nrog kev siv yeeb tshuaj uas tau pom thaum soj ntsuam kev soj ntsuam tau qhia hauv qab no rau cov chav kawm ntawm cov kab mob hauv kev ua kom tsawg zuj zus (feem ntau:> 1/10, feem ntau> 1/100 txog 1/1000 txog 1/10000 rau

Kev Hloov mus rau Lantus los ntawm lwm yam insulin

Yog hais tias tus mob ntshav qab zib tau siv cov tshuaj insulins-nruab nrab, tom qab ntawd thaum hloov mus rau Lantus, qhov ntau thiab kev hloov ntawm cov tshuaj tau hloov pauv. Kev hloov pauv cov kua dej yuav tsum tau nqa tawm hauv tsev kho mob nkaus xwb.

Hauv tebchaws Lavxias, txhua tus mob ntshav qab zib insulin-tau raug tshem tawm ntawm Lantus mus rau Tujeo. Raws li kev tshawb nrhiav, cov tshuaj tshiab muaj qhov txo qis ntawm cov mob ntshav qab zib tsawg, tab sis hauv kev coj ua, cov neeg feem ntau yws tias tom qab hloov mus rau Tujeo lawv cov piam thaj tau dhia ntau, yog li lawv raug yuam yuav Lantus Solostar insulin ntawm lawv tus kheej.

Levemir yog cov tshuaj zoo heev, tab sis nws muaj cov tshuaj sib txawv, txawm tias lub sijhawm ua haujlwm kuj yog 24 teev.

Aylar tsis ntsib insulin, cov lus qhia hais tias qhov no yog tib qho Lantus, tab sis cov chaw tsim khoom pheej pheej yig dua.

Insulin Lantus thaum cev xeeb tub

Cov kev tshawb fawb soj ntsuam ntawm Lantus nrog cov poj niam cev xeeb tub tsis tau ua. Raws li cov ntaub ntawv tsis raug cai, cov tshuaj tsis cuam tshuam loj heev hauv chav kawm ntawm cev xeeb tub thiab tus menyuam nws tus kheej.

Cov kev sim tau nrhiav rau ntawm cov tsiaj, thaum lub sijhawm nws tau ua pov thawj tias insulin glargine tsis muaj qhov phiv rau ntawm kev ua me nyuam.

Cev xeeb tub Lantus Solostar tuaj yeem siv tshuaj yog tias tsis muaj zog tiv thaiv NPH. Cov niam yav tom ntej yuav tsum saib xyuas lawv cov suab thaj, vim tias nyob rau thawj peb lub hlis, xav tau cov tshuaj insulin tuaj yeem txo qis, thiab hauv lub hlis thib ob thiab peb lub hlis.

Tsis txhob ntshai tsam pub niam mis rau tus menyuam noj, cov lus qhia tsis muaj cov ntaub ntawv uas Lantus tuaj yeem nkag mus rau niam mis tau.

Khaws cia li cas

Lub txee lub neej ntawm Lantus yog 3 xyoos. Koj yuav tsum muab cia rau hauv qhov chaw tsaus tiv thaiv los ntawm tshav ntuj ntawm qhov kub ntawm 2 txog 8 degrees. Feem ntau qhov chaw zoo tshaj plaws yog tub yees. Hauv qhov no, nco ntsoov saib cov txheej txheem kub, vim tias qhov txias khov ntawm cov tshuaj insulin Lantus yog txwv!

Txij li thaum siv thawj zaug, cov tshuaj yuav khaws cia rau ib hlis nyob rau hauv qhov chaw tsaus ntawm qhov kub ntawm tsis ntau tshaj 25 degrees (tsis nyob hauv tub yees). Tsis txhob siv cov tshuaj insulin uas tas sij hawm.

Qhov twg yuav, nqe

Lantus Solostar yog tshuaj dawb los ntawm kev muab tshuaj los ntawm cov kws kho keeb endocrinologist. Tab sis nws kuj tshwm sim uas tus neeg mob ntshav qab zib yuav tsum yuav nws cov tshuaj no ntawm nws tus kheej ntawm lub tsev muag tshuaj. Tus nqi nruab nrab ntawm cov tshuaj insulin yog 3300 rubles. Hauv Ukraine, Lantus tuaj yeem yuav rau 1200 UAH.

Lantus yog qhov yuav npaj cov insulin-txos qis dua. Qhov nquag ua haujlwm ntawm lub lantus yog cov tshuaj insulin glargine - ib qho khoom sib piv ntawm tib neeg cov tshuaj insulin, tsis zoo rau hauv ib puag ncig nruab nrab.

Hauv kev npaj Lantus, cov tshuaj yeeb yaj kiab kom yaj vim qhov tshwj xeeb acidic nruab nrab, thiab nrog kev tswj hwm subcutaneous, cov kua qaub yog neutralized thiab microprecipitates yog tsim, ntawm uas insulin glargine maj mam tso tawm hauv cov khoom me me. Yog li, nyob rau hauv cov ntshav ntshav tsis muaj qhov txawv txav ntawm cov kua dej, tab sis pom qhov muaj qhov sib luag ntawm cov concentration-sijhawm nkhaus yog pom. Microprecipitate muab cov tshuaj ua nrog lub sijhawm ntev.

Pharmacological kev ua

Qhov nquag ua haujlwm ntawm lub lantus muaj qhov sib txuam rau insulin receptors zoo ib yam li kev sib raug zoo rau tib neeg cov insulin. Glargine khi rau cov tshuaj insulin receptor IGF-1 5-8 zaug muaj zog dua li tib neeg cov insulin, thiab nws cov metabolites tsis muaj zog.

Kev kho kom haum siab ntawm kev sib koom ua ke ntawm cov nquag muaj feem ntawm insulin thiab nws cov metabolites hauv cov ntshav ntawm cov neeg mob ntshav qab zib hom ntshav qab zib qis qis dua qhov tsim nyog kom ntseeg tau tias ib nrab-qhov siab tshaj qhov txuas nrog IGF-1 receptors thiab txuas ntxiv ua rau cov kab mob mitogen-proliferative catalyzed los ntawm cov tshuaj no.

Cov txheej txheem no ib txwm ua haujlwm los ntawm endogenous IGF-1, tab sis cov tshuaj siv tshuaj tua kab mob siv hauv kev siv tshuaj insulin yog qhov qis dua li qhov kev siv tshuaj pharmacological uas tsim nyog los ua rau lub cev los ntawm IGF-1.

Lub luag haujlwm tseem ceeb ntawm ib qho insulin, suav nrog glargine, yog kev cai ntawm cov piam thaj glucose (carbohydrate metabolism). Cov tshuaj insulin lantus ua kom nrawm nrawm rau cov piam thaj los ntawm adipose thiab cov leeg nqaij, vim qhov ntawd ua rau ntshav plasma cov ntshav qab zib tsawg dua. Tsis tas li, cov tshuaj no inhibits qhov ua haujlwm ntawm cov piam thaj hauv lub siab.

Cov tshuaj Insulin ua kom lub zog ntawm cov protein nyob hauv lub cev, thaum tab tom ua kom cov txheej txheem ntawm cov khoom (proteolysis) thiab lipolysis hauv adipocytes.

Cov kev tshawb fawb soj ntsuam thiab chaw muag tshuaj tau qhia tias thaum muab tshuaj rau tib leeg, qhov tshuaj tiv thaiv tib yam nkaus ntawm insulin glargine thiab tib neeg insulin yog qhov sib npaug. Qhov kev ua ntawm insulin glargine hauv lub sijhawm, zoo li lwm tus neeg sawv cev ntawm qhov koob no, nyob ntawm kev ua haujlwm ntawm lub cev thiab ntau lwm yam.

Nrog rau kev tswj hwm subcutaneous, cov tshuaj Lantus yog maj mam nqus, kom nws tuaj yeem siv ib hnub ib zaug. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias muaj cov kev paub cuam tshuam kev hloov pauv txawv hauv qhov xwm ntawm kev ua ntawm insulin lub sijhawm. Cov kev tshawb fawb pom tau tias qhov kev hloov pauv ntawm cov ntshav qab zib ua kom tsis muaj qhov sib txawv loj thaum siv insulin glargine thiab insulin NPH.

Nrog kev siv cov Lantus hauv cov menyuam yaus thiab cov hluas, kev txhim kho ntawm nocturnal hypoglycemia pom muaj tsawg dua li nyob hauv pawg ntawm cov neeg mob tau txais NPH insulin.

Tsis zoo li insulin NPH, glargine vim kev nqus sai tsis ua rau lub ncov tom qab kev tswj hwm subcutaneous. Kev sib luag ntawm cov tshuaj nyob rau hauv cov ntshav ntshav yog pom rau ntawm 2 - 4 hnub ntawm kev kho mob nrog rau kev tswj hwm niaj hnub ib zaug.Ib nrab-lub neej ntawm insulin glargine thaum tswj cov tshuaj sib raug rau lub sijhawm zoo sib xws ntawm tib neeg insulin.

Nrog cov metabolism hauv ntawm cov tshuaj insulin glargine, qhov tsim ntawm ob lub tebchaw nquag M1 thiab M2 tshwm sim. Kev txhaj tshuaj Subantaneous ntawm Lantus muaj lawv cov txiaj ntsig tseem ceeb vim yog raug rau M1, thiab M2 thiab insulin glargine tsis raug kuaj nyob hauv feem ntau ntawm cov ncauj lus.

Qhov ua tau zoo ntawm cov tshuaj Lantus yog ib yam hauv pawg sib txawv ntawm cov neeg mob. Hauv chav kawm ntawm cov kev tshawb fawb, pab pawg tau tsim los ntawm hnub nyoog thiab poj niam txiv neej, thiab cov nyhuv ntawm cov tshuaj insulin hauv lawv yog tib yam li cov pej xeem tseem ceeb (raws li kev ua tau zoo thiab kev nyab xeeb). Hauv cov menyuam yaus thiab tub ntxhais hluas, kev tshawb fawb pharmacokinetics tsis tau ua.

Kev ntsuas rau siv

1. Cov neeg laus thiab menyuam yaus txij li 2 xyoos muaj mob ntshav qab zib hom 1.
2. Hom 2 mob ntshav qab zib mellitus (nyob rau hauv cov ntaub ntawv tsis muaj txiaj ntsig ntawm cov ntsiav tshuaj).

Hauv kev rog, kev sib koom ua ke yuav kho tau zoo - Lantus Solostar thiab Metformin.

Kev cuam tshuam nrog lwm yam tshuaj

Muaj cov tshuaj uas cuam tshuam rau cov metabolism hauv cov metabolism, thaum nce los yog txo qis yuav tsum muaj cov insulin.

Txo cov piam thaj: cov tshuaj tiv thaiv kab mob hauv lub cev, sulfonamides, ACE inhibitors, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Qab zib kom ntau: cov thyroid hormones, diuretics, sympathomimetics, tshuaj tiv thaiv qhov ncauj, phenothiazine derivatives, protease inhibitors.

Qee yam tshuaj muaj ob qho ua kom tsis pom kev thiab qhov ua tsis zoo. Cov no suav nrog:

• beta blockers thiab ntsev lithium,
• cawv
• clonidine (antihypertensive tshuaj).

Cov Yuav Tsum Muaj

1. Nws yog txwv tsis pub siv rau hauv cov neeg mob uas tsis nkag siab rau insulin glargine lossis ntu sib xyaw.
2. Kev ntshav siab.
3. Kev kho mob ntawm cov ntshav qab zib ketoacidosis.
4. Cov me nyuam qis dua 2 xyoos.

Ua tau qhov tsis zoo tshwm sim tsawg tsawg, cov lus qhia tau hais tias tej zaum yuav muaj:

• lipoatrophy los yog lipohypertrophy,
• kev ua xua (Quincke's edema, kev tsis haum, tshuaj bronchospasm),
• mob nqaij thiab mob qeeb hauv lub cev ntawm sodium ions,
• mob plab thiab qhov muag tsis pom kev.

Kev Hloov mus rau Lantus los ntawm lwm yam insulin

Yog hais tias tus mob ntshav qab zib tau siv cov tshuaj insulins-nruab nrab, tom qab ntawd thaum hloov mus rau Lantus, qhov ntau thiab kev hloov ntawm cov tshuaj tau hloov pauv. Kev hloov pauv cov kua dej yuav tsum tau nqa tawm hauv tsev kho mob nkaus xwb.

Hauv tebchaws Lavxias, txhua tus mob ntshav qab zib insulin-tau raug tshem tawm ntawm Lantus mus rau Tujeo. Raws li kev tshawb nrhiav, cov tshuaj tshiab muaj qhov txo qis ntawm cov mob ntshav qab zib tsawg, tab sis hauv kev coj ua, cov neeg feem ntau yws tias tom qab hloov mus rau Tujeo lawv cov piam thaj tau dhia ntau, yog li lawv raug yuam yuav Lantus Solostar insulin ntawm lawv tus kheej.

Levemir yog cov tshuaj zoo heev, tab sis nws muaj cov tshuaj sib txawv, txawm tias lub sijhawm ua haujlwm kuj yog 24 teev.

Aylar tsis ntsib insulin, cov lus qhia hais tias qhov no yog tib qho Lantus, tab sis cov chaw tsim khoom pheej pheej yig dua.

Insulin Lantus thaum cev xeeb tub

Cov kev tshawb fawb soj ntsuam ntawm Lantus nrog cov poj niam cev xeeb tub tsis tau ua. Raws li cov ntaub ntawv tsis raug cai, cov tshuaj tsis cuam tshuam loj heev hauv chav kawm ntawm cev xeeb tub thiab tus menyuam nws tus kheej.

Cov kev sim tau nrhiav rau ntawm cov tsiaj, thaum lub sijhawm nws tau ua pov thawj tias insulin glargine tsis muaj qhov phiv rau ntawm kev ua me nyuam.

Cev xeeb tub Lantus Solostar tuaj yeem siv tshuaj yog tias tsis muaj zog tiv thaiv NPH. Cov niam yav tom ntej yuav tsum saib xyuas lawv cov suab thaj, vim tias nyob rau thawj peb lub hlis, xav tau cov tshuaj insulin tuaj yeem txo qis, thiab hauv lub hlis thib ob thiab peb lub hlis.

Tsis txhob ntshai tsam pub niam mis rau tus menyuam noj, cov lus qhia tsis muaj cov ntaub ntawv uas Lantus tuaj yeem nkag mus rau niam mis tau.

Khaws cia li cas

Lub txee lub neej ntawm Lantus yog 3 xyoos. Koj yuav tsum muab cia rau hauv qhov chaw tsaus tiv thaiv los ntawm tshav ntuj ntawm qhov kub ntawm 2 txog 8 degrees.Feem ntau qhov chaw zoo tshaj plaws yog tub yees. Hauv qhov no, nco ntsoov saib cov txheej txheem kub, vim tias qhov txias khov ntawm cov tshuaj insulin Lantus yog txwv!

Txij li thaum siv thawj zaug, cov tshuaj yuav khaws cia rau ib hlis nyob rau hauv qhov chaw tsaus ntawm qhov kub ntawm tsis ntau tshaj 25 degrees (tsis nyob hauv tub yees). Tsis txhob siv cov tshuaj insulin uas tas sij hawm.

Qhov twg yuav, nqe

Lantus Solostar yog tshuaj dawb los ntawm kev muab tshuaj los ntawm cov kws kho keeb endocrinologist. Tab sis nws kuj tshwm sim uas tus neeg mob ntshav qab zib yuav tsum yuav nws cov tshuaj no ntawm nws tus kheej ntawm lub tsev muag tshuaj. Tus nqi nruab nrab ntawm cov tshuaj insulin yog 3300 rubles. Hauv Ukraine, Lantus tuaj yeem yuav rau 1200 UAH.

Lantus yog qhov yuav npaj cov insulin-txos qis dua. Qhov nquag ua haujlwm ntawm lub lantus yog cov tshuaj insulin glargine - ib qho khoom sib piv ntawm tib neeg cov tshuaj insulin, tsis zoo rau hauv ib puag ncig nruab nrab.

Hauv kev npaj Lantus, cov tshuaj yeeb yaj kiab kom yaj vim qhov tshwj xeeb acidic nruab nrab, thiab nrog kev tswj hwm subcutaneous, cov kua qaub yog neutralized thiab microprecipitates yog tsim, ntawm uas insulin glargine maj mam tso tawm hauv cov khoom me me. Yog li, nyob rau hauv cov ntshav ntshav tsis muaj qhov txawv txav ntawm cov kua dej, tab sis pom qhov muaj qhov sib luag ntawm cov concentration-sijhawm nkhaus yog pom. Microprecipitate muab cov tshuaj ua nrog lub sijhawm ntev.

Pharmacological kev ua

Qhov nquag ua haujlwm ntawm lub lantus muaj qhov sib txuam rau insulin receptors zoo ib yam li kev sib raug zoo rau tib neeg cov insulin. Glargine khi rau cov tshuaj insulin receptor IGF-1 5-8 zaug muaj zog dua li tib neeg cov insulin, thiab nws cov metabolites tsis muaj zog.

Kev kho kom haum siab ntawm kev sib koom ua ke ntawm cov nquag muaj feem ntawm insulin thiab nws cov metabolites hauv cov ntshav ntawm cov neeg mob ntshav qab zib hom ntshav qab zib qis qis dua qhov tsim nyog kom ntseeg tau tias ib nrab-qhov siab tshaj qhov txuas nrog IGF-1 receptors thiab txuas ntxiv ua rau cov kab mob mitogen-proliferative catalyzed los ntawm cov tshuaj no.

Cov txheej txheem no ib txwm ua haujlwm los ntawm endogenous IGF-1, tab sis cov tshuaj siv tshuaj tua kab mob siv hauv kev siv tshuaj insulin yog qhov qis dua li qhov kev siv tshuaj pharmacological uas tsim nyog los ua rau lub cev los ntawm IGF-1.

Lub luag haujlwm tseem ceeb ntawm ib qho insulin, suav nrog glargine, yog kev cai ntawm cov piam thaj glucose (carbohydrate metabolism). Cov tshuaj insulin lantus ua kom nrawm nrawm rau cov piam thaj los ntawm adipose thiab cov leeg nqaij, vim qhov ntawd ua rau ntshav plasma cov ntshav qab zib tsawg dua. Tsis tas li, cov tshuaj no inhibits qhov ua haujlwm ntawm cov piam thaj hauv lub siab.

Cov tshuaj Insulin ua kom lub zog ntawm cov protein nyob hauv lub cev, thaum tab tom ua kom cov txheej txheem ntawm cov khoom (proteolysis) thiab lipolysis hauv adipocytes.

Cov kev tshawb fawb soj ntsuam thiab chaw muag tshuaj tau qhia tias thaum muab tshuaj rau tib leeg, qhov tshuaj tiv thaiv tib yam nkaus ntawm insulin glargine thiab tib neeg insulin yog qhov sib npaug. Qhov kev ua ntawm insulin glargine hauv lub sijhawm, zoo li lwm tus neeg sawv cev ntawm qhov koob no, nyob ntawm kev ua haujlwm ntawm lub cev thiab ntau lwm yam.

Nrog rau kev tswj hwm subcutaneous, cov tshuaj Lantus yog maj mam nqus, kom nws tuaj yeem siv ib hnub ib zaug. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias muaj cov kev paub cuam tshuam kev hloov pauv txawv hauv qhov xwm ntawm kev ua ntawm insulin lub sijhawm. Cov kev tshawb fawb pom tau tias qhov kev hloov pauv ntawm cov ntshav qab zib ua kom tsis muaj qhov sib txawv loj thaum siv insulin glargine thiab insulin NPH.

Nrog kev siv cov Lantus hauv cov menyuam yaus thiab cov hluas, kev txhim kho ntawm nocturnal hypoglycemia pom muaj tsawg dua li nyob hauv pawg ntawm cov neeg mob tau txais NPH insulin.

Tsis zoo li insulin NPH, glargine vim kev nqus sai tsis ua rau lub ncov tom qab kev tswj hwm subcutaneous. Kev sib luag ntawm cov tshuaj nyob rau hauv cov ntshav ntshav yog pom rau ntawm 2 - 4 hnub ntawm kev kho mob nrog rau kev tswj hwm niaj hnub ib zaug. Ib nrab-lub neej ntawm insulin glargine thaum tswj cov tshuaj sib raug rau lub sijhawm zoo sib xws ntawm tib neeg insulin.

Nrog cov metabolism hauv ntawm cov tshuaj insulin glargine, qhov tsim ntawm ob lub tebchaw nquag M1 thiab M2 tshwm sim.Kev txhaj tshuaj Subantaneous ntawm Lantus muaj lawv cov txiaj ntsig tseem ceeb vim yog raug rau M1, thiab M2 thiab insulin glargine tsis raug kuaj nyob hauv feem ntau ntawm cov ncauj lus.

Qhov ua tau zoo ntawm cov tshuaj Lantus yog ib yam hauv pawg sib txawv ntawm cov neeg mob. Hauv chav kawm ntawm cov kev tshawb fawb, pab pawg tau tsim los ntawm hnub nyoog thiab poj niam txiv neej, thiab cov nyhuv ntawm cov tshuaj insulin hauv lawv yog tib yam li cov pej xeem tseem ceeb (raws li kev ua tau zoo thiab kev nyab xeeb). Hauv cov menyuam yaus thiab tub ntxhais hluas, kev tshawb fawb pharmacokinetics tsis tau ua.

Kev ntsuas rau siv

Lantus yog tsim rau kev kho mob rau cov ntshav qab zib-insulin nyob rau cov neeg laus thiab cov menyuam yaus hnub nyoog tshaj li 6 xyoo.

Cov tshuaj yog siv rau kev coj ua subcutaneous, nws yog txwv tsis pub muab tso rau hauv txoj leeg ntshav. Cov txiaj ntsig ntev ntawm cov roj lantus yog txuam nrog nws cov lus qhia rau hauv cov rog subcutaneous.

Nws yog ib qho tseem ceeb kom tsis txhob hnov ​​qab tias nrog kev tswj hwm ntawm cov tshuaj kho mob ib txwm muaj, cov tshuaj tiv thaiv ntshav qab zib siab hnyav tuaj yeem tsim kho. Thaum siv cov tshuaj no, yuav tsum muaj ntau txoj cai:

1. Thaum lub sijhawm kev kho mob, koj yuav tsum ua raws li qee qhov kev ua neej thiab muab qhov hno kom raug.
2. Koj tuaj yeem nkag mus rau cov tshuaj hauv plab plab, ntxiv rau hauv tus ncej lossis cov leeg txhaws. Tsis muaj qhov sib txawv hauv qhov chaw kho mob nrog cov hau kev ntawm cov thawj coj.
3. Txhua qhov kev txhaj tshuaj yog zoo tshaj plaws nyob rau qhov chaw tshiab hauv thaj chaw pom zoo.
4. Koj tsis tuaj yeem yug Lantus lossis sib tov nws nrog lwm yam tshuaj.

Lantus yog qhov ua yeeb yam ntev ntev, yog li nws yuav tsum tau txhaj tshuaj ib hnub ib zaug, zoo dua rau tib lub sijhawm. Cov koob tshuaj rau txhua tus neeg tau xaiv ib tus zuj zus, nrog rau lub koob thiab lub sijhawm ntawm thawj coj.

Nws yog qhov txaus siab los sau cov tshuaj Lantus rau cov neeg mob uas kuaj mob hom 2 mob ntshav qab zib mellitus ua ke nrog cov tshuaj tiv thaiv kab mob rau kev tswj hwm qhov ncauj.

Nws yog ib qho tseem ceeb uas yuav tau txiav txim siab hais tias cov kev ntsuas ntawm kev ua ntawm cov tshuaj no yog txawv ntawm qhov kev ntsuas ntawm lwm cov tshuaj muaj cov tshuaj insulin.

Cov neeg laus yuav tsum kho lub tshuaj, vim tias lawv tuaj yeem txo qis qhov xav tau ntawm cov tshuaj insulin vim muaj kev puas tsuaj hauv lub raum. Tsis tas li ntawd, nyob rau hauv cov neeg mob uas lub siab tsis ua haujlwm zoo, qhov xav tau ntawm insulin yuav poob qis. Qhov no yog vim qhov tseeb tias cov tshuaj insulin metabolism ua rau qeeb dua, thiab gluconeogenesis tseem txo qis.

Hloov mus rau Kab Ntsuas nrog lwm hom insulin

Yog hais tias ib tus neeg ua ntej siv tshuaj ntawm nruab nrab thiab siab ntev ntawm kev nqis tes ua, tom qab ntawd hloov mus rau Lantus, feem ntau nws yuav xav kho qhov tshuaj ntawm cov tshuaj inulin, nrog rau kev tshuaj xyuas cov kev kho mob.

Txhawm rau txo qis kev pheej hmoo ntawm cov ntshav qog ntshav thaum sawv ntxov thiab thaum tsaus ntuj, thaum hloov lub sijhawm ob lub sijhawm tswj hwm ntawm basal insulin (NPH) rau kev txhaj tshuaj ib leeg (Lantus), qhov tshuaj ntawm cov tshuaj insal basal yuav tsum tau txo 20-30% thaum thawj nees nkaum hnub ntawm kev kho mob. Thiab cov koob tshuaj ntawm cov tshuaj insulin muab txuas nrog kev noj mov yuav tsum tau nce ntxiv me ntsis. Tom qab ob mus rau peb lub lis piam, kev hloov kho tshuaj yuav tsum tau nqa tawm ntawm tus kheej rau txhua tus neeg mob.

Yog tias tus neeg mob tau txais cov tshuaj tiv thaiv rau tib neeg cov tshuaj insulin, tom qab ntawd thaum siv Lantus, lub cev cov lus teb rau cov tshuaj insulin hloov pauv, uas tseem yuav xav tau kev tshuaj xyuas. Nws tseem yog qhov tsim nyog thaum hloov txoj kev ua neej, hloov qhov hnyav ntawm lub cev lossis lwm yam cuam tshuam uas cuam tshuam rau kev coj ua ntawm cov tshuaj.

Cov tshuaj Lantus yuav tsum raug tswj hwm tsuas yog siv OptiPen Pro1 lossis ClickSTAR koob txhaj tshuaj. Ua ntej pib siv, koj yuav tsum ua tib zoo kawm cov lus qhia rau tus cwj mem thiab ua raws txhua qhov kev lag luam cov lus pom zoo. Qee txoj cai siv cov xaum xim siv:

1. Yog tias tus kov tawg, ces nws yuav tsum tau muab pov tseg thiab ib qho tshiab siv.
2. Yog tias tsim nyog, cov tshuaj los ntawm daim cartridge tuaj yeem raug tswj nrog cov tshuaj insulin tshwj xeeb nrog ib nplai ntawm 100 units hauv 1 ml.
3. Lub taub ntim yuav tsum khaws cia ntawm chav tsev qhov chaw sov li ob peb teev ua ntej muab tso rau hauv cov xaum xaum.
4. Koj tuaj yeem siv cov kab ntawv ntawd nkaus xwb uas qhov pom ntawm kev daws tsis tau hloov, nws cov xim thiab qhov pom, tsis muaj nag lossis daus tau tshwm sim.
5. Ua ntej qhia kev daws los ntawm daim cartridge, nco ntsoov tshem cov pa npuas (yuav ua li cas, nws tau sau nyob rau hauv cov lus qhia rau tus cwj mem).
6. Refilling cartridges yog nruj me ntsis txwv tsis pub.
7. Txhawm rau tiv thaiv kev raug mob los ntawm lwm yam tshuaj insulin es tsis txhob siv cov glargine, nws yog qhov yuav tsum tau kuaj xyuas cov ntawv lo ntawm txhua qhov kev txhaj tshuaj.

Sab sij huam

Feem ntau cov feem ntau, hauv cov neeg mob uas tsis nco qab zoo thaum siv cov tshuaj Lantus yog hypoglycemia. Nws muaj kev vam meej yog tias cov tshuaj tau muab tshuaj rau hauv ntau npaum li qhov tsim nyog rau tus neeg mob. Cov kev tsis zoo hauv qab no kuj tseem yuav tshwm sim rau kev qhia ntawm Lantus:

• los ntawm cov kev paub ntawm cov plab hnyuv siab raum thiab lub paj hlwb - dysgeusia, kev tsis pom zoo hauv kev pom tseeb, rov ua haujlwm,
• nyob rau ntawm daim tawv nqaij, nrog rau cov nqaij mos ua kom raug mob - lipohypertrophy thiab lipoatrophy,
• hypoglycemia (teeb meem metabolic tsis txaus),
• kev tsis haum - ua pob thiab liab ntawm daim tawv nqaij ntawm thaj chaw txhaj tshuaj, urticaria, anaphylactic shock, bronchospasm, Quincke's edema,
• kev ncua ntawm sodium ions hauv lub cev, mob leeg.

Nws yuav tsum tau yug los rau hauv lub siab tias yog qhov kev mob ntshav qab zib ntau dhau los, feem ntau txoj kev pheej hmoo ntawm kev tsim teeb meem nyob rau hauv kev ua haujlwm ntawm lub paj hlwb tau siab. Ntev ntshav siab thiab ntshav qis yog qhov txaus ntshai rau tus neeg mob lub neej.

Thaum kho cov tshuaj insulin, cov tshuaj tiv thaiv tuaj yeem tsim cov tshuaj.

Hauv cov menyuam yaus thiab tub ntxhais hluas, Lantus tuaj yeem txhim kho qhov tsis xav txog xws li mob leeg, qhov tshwm sim tsis haum, thiab mob ntawm qhov chaw txhaj tshuaj. Feem ntau, rau ob tus laus thiab menyuam yaus, kev nyab xeeb ntawm Lantus yog nyob rau tib theem.

Lantus thiab cev xeeb tub

Hauv cov poj niam cev xeeb tub, tsis tau tshawb nrhiav qhov kev tshawb fawb txog cov tshuaj no tau ua tiav. Cov ntaub ntawv tau tsuas yog nyob rau hauv kev tshawb fawb tom qab kev lag luam (kwv yees li 400 - 1000 tus neeg mob), thiab lawv tau qhia tias insulin glargine tsis muaj kev cuam tshuam zoo rau lub sijhawm cev xeeb tub thiab kev loj hlob ntawm tus menyuam.

Cov tsiaj sim tau pom tias insulin glargine tsis muaj kev phom sij rau lub cev xeeb tub thiab tsis ua rau muaj kev cuam tshuam txog kev muaj menyuam.

Cov poj niam cev xeeb tub Lantus tuaj yeem raug xaj los ntawm kws kho mob yog tias tsim nyog. Nws yog ib qho tseem ceeb nyob rau tib lub sijhawm los saib xyuas cov kua qab zib txhua tus thiab ua txhua yam kom muaj, nrog rau saib xyuas cov kev mob ntawm leej niam uas tseem tos thaum lub sijhawm xeeb tub. Hauv thawj peb lub hlis, xav tau cov tshuaj insulin yuav txo qis, thiab hauv kev txiav thib ob thiab thib peb, nce ntxiv. Tam sim ntawd tom qab yug tus menyuam tas, lub cev xav tau cov tshuaj no poob qis thiab ntshav qabzib tau pib.

Nrog rau qhov lactation, kev siv cov Lantus tseem ua tau nyob rau hauv kev soj ntsuam ze ntawm kev noj tshuaj ntau npaum li cas. Thaum nqus tau rau hauv lub plab zom mov, insulin glargine raug faib ua amino acids thiab tsis ua rau muaj kev phom sij rau tus menyuam los ntawm kev pub niam mis. Cov lus qhia uas glargine kis mus rau niam cov kua mis, cov lus qhia tsis muaj.

Noj ntau dhau

Kev noj tshuaj ntau dhau ntawm cov yeeb yaj kiab Lantus tuaj yeem ua rau mob hnyav, ua kom ntev thiab mob ntshav qab zib tsawg, uas yog qhov txaus ntshai rau kev noj qab haus huv thiab lub neej ntawm tus neeg mob. Yog hais tias kev noj haus ntau dhau tsis zoo qhia, nws tuaj yeem nres los ntawm kev siv carbohydrates.

Thaum muaj kev txhim kho tsis tu ncua ntawm hypoglycemia, tus neeg mob yuav tsum hloov nws txoj kev ua neej thiab kho qhov koob tshuaj uas tau siv rau kev siv.

3 ml cartridges thiab SoloStar syringe cwjmem

1 ml ntawm cov tshuaj muaj:

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), dej rau kev txhaj tshuaj.

1 ml ntawm cov tshuaj muaj:

cov tshuaj nquag: insulin glargine - 3.6378 mg, uas sib raug rau 100 PIECES ntawm tib neeg cov tshuaj insulin.

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), polysorbate 20, dej rau kev txhaj tshuaj.

Cov tshuaj insulin glargine tau los ntawm kev rov ua kom tiav ntawm cov kab mob DNA ntawm hom Escherichia coli.

ntshiab, tsis muaj kob.

Kev cuam tshuam nrog lwm yam tshuaj

Ib tug xov tooj ntawm cov tshuaj cuam tshuam rau cov metabolism hauv cov piam thaj, uas yuav xav tau kev kho kom haum rau cov tshuaj insulin glargine.

Qhia rau koj tus kws kho mob txog TXHUA yam tshuaj uas koj noj, txawm tias nws tshwm sim ib qhov dhau ib ntawm!

Kev npaj uas tuaj yeem txhim kho hypoglycemic ua haujlwm ntawm cov tshuaj insulin thiab nce lub ntsiab lus rau kev txhim kho hypoglycemia suav nrog cov tshuaj tiv thaiv hypoglycemic qhov ncauj, angiotensin-hloov ua ntej enzyme inhibitors, disopyramides, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, propoxyphenic sulfamic amines.

Cov tshuaj uas tuaj yeem ua rau cov ntshav tsis txaus ntawm cov insulin muaj xws li corticosteroids, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens, progestogens, phenothiazine derivatives, somatotropin, sympathomimetics (piv txwv, epinephrine adrenaline, salbutamol, gerbitonazole) qee cov tshuaj tiv thaiv kev ua haujlwm (piv txwv li olanzapine lossis clozapine).

Tsis tas li ntawd, nyob rau hauv kev cuam tshuam ntawm qee cov tshuaj tiv thaiv kev tiv thaiv mob, cov tsos mob ua ntej rau lub qog ntshav yuav txo qis lossis qhaj.

Cov Lus Qhia Sib Tw

Cov tshuaj no tsis tuaj yeem sib xyaw nrog lwm cov tshuaj. Nco ntsoov tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj.

Daim ntawv thov nta

Kev tswj hwm qhov tsis muaj txiaj ntsig nyob rau theem ntawm cov piam thaj hauv cov ntshav, zoo li yog tias muaj kev nyiam los txhim kho hypo- lossis hyperglycemia, ua ntej taug kev nrog kev kho ntawm cov tshuaj ntau npaum li cas, nws yog qhov yuav tsum tau kuaj xyuas qhov tseeb ntawm kev ua raws li cov txheej txheem kev kho mob, qhov chaw ntawm kev saib xyuas ntawm cov tshuaj thiab cov txheej txheem ntawm kev txhaj tshuaj subcutaneous kom tsim nyog, muab txhua yam cuam tshuam nrog qhov teeb meem. Yog li ntawd, ua tib zoo saib xyuas nws tus kheej thiab khaws phau ntawv khaws cia yog xav pom zoo.

Hloov mus rau lwm hom lossis hom tshuaj insulin yuav tsum tau ua nyob ntawm kev saib xyuas mob nkeeg nruj me ntsis. Hloov pauv ntawm cov tshuaj, cov chaw tsim khoom, hom (NPH, ua yeeb yam luv luv, ua yeeb yam ntev, thiab lwm yam), keeb kwm (tsiaj, tib neeg, tib neeg insulin analogue) thiab / lossis cov txheej txheem ntau lawm yuav tsum tau hloov kho koob tshuaj.

Lub sijhawm ntawm kev txhim kho hypoglycemia yog nyob ntawm qhov profile ntawm kev ua ntawm kev siv tshuaj insulin thiab yuav, yog li ntawd, hloov nrog qhov hloov pauv ntawm kev kho mob. Vim tias qhov nce ntxiv nyob rau lub sijhawm nws yuav siv sijhawm ntev rau insulin tuaj rau hauv lub cev thaum siv Lantus, ib qho yuav tsum cia siab tias yuav muaj tsawg dua ntawm kev txhim kho nocturnal hypoglycemia, thaum tseem yuav tshwm sim thaum ntxov thaum sawv ntxov.

Cov neeg mob uas cov neeg mob ntshav qab zib tsawg yuav muaj tej yam tseem ceeb hauv kev kho mob, xws li cov neeg mob uas mob hlab ntsha hauv cov hlab ntshav lossis cov hlab ntsha hlwb tsis zoo (muaj kev pheej hmoo ntawm kev mob plawv thiab mob hlwb ntawm hypoglycemia), nrog rau cov neeg mob uas muaj hlwb ntau dua, tshwj xeeb yog tias lawv tsis tau txais kev kho mob nrog photocoagulation (muaj kev pheej hmoo dhau mus los ntawm qhov tsis pom kev vim yog ntshav tsis txaus), yuav tsum tau saib xyuas tshwjxeeb, thiab yuav tsum tau saib xyuas ntau dua thiab saib xyuas cov ntshav qabzib kom zoo.

Nco ntsoov tias hauv qee kis xwm txheej uas cov tsos mob ntawm lub zam ua ntej hypoglycemia tuaj yeem hloov pauv, dhau los ua suab tsawg lossis tsis tuaj rau hauv:

Cov neeg mob uas tau pom tias tau nce cov ntshav qabzib nyob rau txoj cai

Cov neeg mob hauv tus neeg ntshav qab zib tsawg zuj zus

Cov neeg laus cov neeg mob

Cov neeg mob tom qab hloov los ntawm insulin ntawm tsiaj keeb kwm rau tib neeg insulin,

Cov neeg mob neuropathy,

Cov neeg mob uas muaj mob ntshav qab zib ntev,

Cov Neeg Mob Muaj Mob Puas Hlwb

cov neeg mob tau txais kev kho mob nrog lwm yam tshuaj (saib Kev Sib Koom Nrog nrog lwm cov tshuaj).

Lub caij nyoog ntev ntawm cov kab mob subcutaneous tswj hwm ntawm insulin glargine tuaj yeem ua rau qeeb rov qab tom qab kev txhim kho hypoglycemia.

Yog hais tias ib txwm los qis qis glycosylated hemoglobin qib raug sau tseg, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv tus lej muaj peev xwm tsim kev tshwm sim tsis nco qab txog kev mob ntshav qab zib (tshwj xeeb tshaj yog thaum tsaus ntuj).

Cov neeg mob ua raws li kev noj tshuaj, kev noj haus thiab kev noj zaub mov zoo, kev siv tshuaj insulin kom zoo thiab kev tswj hwm ntawm qhov pib ntawm cov tsos mob ntawm lub qog ntshav qab zib ua rau txo qis tseem ceeb ntawm qhov kev pheej hmoo ntawm hypoglycemia. Qhov tseeb uas ua rau kom qhov mob ntshav siab tsis txaus txog qhov yuav tsum tau saib xyuas tshwj xeeb, raws li tej zaum yuav siv tshuaj kho cov tshuaj insulin. Tej yam no suav nrog:

Hloov chaw ntawm cov thawj coj ntawm insulin,

Ua kom nkag siab zoo rau insulin (piv txwv li, thaum tshem tawm cov kev ntxhov siab),

Kev siv tsis raws cai, nce lossis ua lub cev ntev,

Cov kab mob sib xyaw nrog los ntuav, raws plab,

Ua txhaum ntawm kev noj haus thiab kev noj haus,

Skipped noj mov

Qee qhov mob ua rau endocrine tsis meej (piv txwv li, hypothyroidism, adenohypophysis tsis txaus lossis adrenal cortex),

Concomitant kev kho mob nrog lwm yam tshuaj (saib Sib cuam tshuam nrog lwm cov tshuaj).

Hauv cov kab mob sib kis, yuav tsum muaj kev saib xyuas ntshav qabzib ntau dua. Feem ntau, kev tshawb xyuas tau ua rau muaj ketone lub cev nyob hauv cov zis, thiab kev noj tshuaj insulin feem ntau xav tau. Qhov kev xav tau rau insulin feem ntau nce. Cov neeg mob ntshav qab zib hom 1 yuav tsum txuas ntxiv kev haus tsawg kawg yog ib qho me me ntawm carbohydrates, txawm tias lawv muaj peev xwm noj zaub mov ntau hauv tsawg los yog noj tsis tau txhua yam yog tias lawv ntuav, thiab lwm yam. Cov neeg mob no yuav tsum tsis txhob tso tseg txoj kev siv tshuaj insulin.

Kev kho mob yuam kev tau tshaj tawm thaum lwm cov insulins, tshwj xeeb tshaj yog cov insulins luv luv, tau raug yuam cai siv es tsis txhob siv cov glargine insulin. Daim paib insulin yuav tsum tau kuaj xyuas txhua zaus ua ntej txhaj tshuaj kom tsis txhob muaj qhov ua yuam kev kho mob ntawm insulin glargine thiab lwm yam insulins.

Kev sib xyaw ntawm Lantus thiab pioglitazone

Cov neeg muaj mob plawv tsis txaus qhia thaum pioglitazone tau siv nrog kev siv tshuaj insulin, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj feem ua rau muaj mob plawv tsis ua hauj lwm. Qhov no yuav tsum tau coj mus rau hauv tus account thaum sau ntawv ntawm kev sib xyaw ntawm pioglitazone thiab Lantus. Thaum noj cov tshuaj sib xyaw ua ke, nws yog ib qhov tsim nyog los saib xyuas cov neeg mob nyob rau hauv kev sib txuas nrog cov tsos mob tshwm sim thiab cov tsos mob ntawm lub plawv tsis ua hauj lwm, hnyav ntxiv thiab edema.

Pioglitazone yuav tsum tsis ua mus ntxiv yog tias muaj qhov tsis txaus ntseeg ntawm cov tsos mob ntawm lub plawv tsis ua haujlwm.

Kev cuam tshuam rau kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog cov txheej txheem nyuaj

Tus neeg mob lub peev xwm mloog zoo thiab teb sai sai rau lwm qhov sab nraud tuaj yeem ua tsis tau zoo vim qhov kev txhim kho ntawm hypoglycemia lossis hyperglycemia, lossis, piv txwv li los ntawm qhov muag tsis pom kev. Qhov no tuaj yeem ua kev pheej hmoo nyob rau qee qhov xwm txheej uas qhov peev xwm no muaj qhov tseem ceeb tshwj xeeb (piv txwv, thaum tsav tsheb lossis thaum ua haujlwm nrog cov txheej txheem nyuaj).

Tus neeg mob yuav tsum tau txais kev ceeb toom qhia txog kev ceev faj kom tsis txhob muaj kev txhim kho hypoglycemia thaum tsav.Qhov no yog qhov tseem ceeb tshwj xeeb rau cov neeg mob uas tau txo qis lossis tsis paub txog cov kev hem thawj ntawm tus mob ntshav qab zib tsawg, nrog rau cov neeg mob uas feem ntau muaj kev mob ntshav qab zib. Kev ua tib zoo saib xyuas yuav tsum tau muab rau kev muaj peev xwm ntawm kev tsav tsheb los yog ua haujlwm nrog cov txheej txheem nyuaj hauv cov xwm txheej no.

Kev daws ntawm cov tshuaj rau hauv hwj yog 2 xyoos.

Kev daws ntawm cov tshuaj hauv daim cartridges thiab hauv SoloStarSt koob txhaj tshuaj yog 3 xyoos.

Tom qab hnub tas sijhawm, cov tshuaj tsis tuaj yeem siv.

Lus Cim: lub txee lub neej ntawm cov tshuaj los ntawm lub sijhawm siv thawj zaug yog 4 lub lis piam. Nws raug nquahu kom khij hnub ntawm thawj zaug tshem tawm cov tshuaj ntawm daim ntawv lo.

Lantus yog ib qho tshuaj hypoglycemic siv los kho ntshav qab zib.

Cov ntawv tso tawm thiab tus nqi ntawm cov tshuaj

Cov tshuaj nquag siv ntawm cov tshuaj yog cov tshuaj hormone glargine. Cov qhua (excipients) tseem ntxiv rau nws: zinc chloride, hydrochloric acid, m-cresol, sodium hydroxide, dej rau kev txhaj tshuaj thiab glycerol. Cov tshuaj no nws txawv ntawm ntau lwm yam tshuaj insulin hauv nws daim ntawv tso tawm.

• OptiKlik - ib pob muaj 5 daim cartridges ntawm 3 ml txhua. Cartridges tau ua los ntawm cov iav ntshiab.
• Daim duab syringe, siv yooj yim - nrog kov ntawm cov ntiv tes, kuj tseem tsim rau 3ml.
• Lantus SoloStar daim cartridges muaj 3 ml ntawm cov tshuaj. Cov cartridges no tau nruab rau hauv cov xaum npuav. Muaj 5 npiv xws li hauv pob, tsuas yog lawv muag yam tsis muaj rab koob.

Cov tshuaj no yog cov tshuaj kho ntev. Tab sis pes tsawg Lantus insulin raug nqi?

Cov tshuaj raug muag los ntawm cov tshuaj, nws tau dav faib ntawm cov neeg mob ntshav qab zib, nws tus nqi nruab nrab yog 3200 rubles.

Insulin Lantus yog ib hom tshuaj uas muaj suab thaj hauv lub cev. Tus nquag ua hauj lwm yog insulin glargine. Qhov no yog ib qho piv txwv ntawm tib neeg cov kua dej, uas tsis zoo rau hauv kev cuam tshuam hauv nruab nrab. Hauv cov khw muag tshuaj koj tuaj yeem pom 3 daim ntawv ntawm kev tso tawm cov tshuaj: OptiSet syringe cwj mem, OptiClick thiab Lantus SoloStar tshuab. Dab tsi yog cov yam ntxwv ntawm kev siv tshuaj?

Cov tshuaj Insulin Lantus muaj cov nyhuv ntev ntev, txhim kho cov metabolism hauv cov piam thaj thiab tswj cov metabolism hauv kev ua kom rog. Thaum noj tshuaj, qab zib kom tsawg los ntawm cov nqaij thiab cov nqaij rog yog ceev. Tsis tas li, tus neeg sawv cev hormonal ua kom cov protein ntau. Tib lub sijhawm, proteolysis thiab lipolysis hauv adipocytes yog inhibited.

Cov lus qhia rau kev siv

Ua cov txheej txheem ib hnub ib zaug tib lub sijhawm. Kev txhaj tshuaj rau hauv qhov ncauj kom zoo yuav tsum nruj me ntsis. Txhawm rau kom tsis txhob lipodystrophy, hloov thaj chaw txhaj tshuaj.

Cov koob tshuaj ntawm cov tshuaj yog nyob ntawm qhov hnyav ntawm tus neeg mob, nws txoj kev ua neej thiab lub sijhawm ntawm kev tswj hwm ntawm cov tshuaj. Nws yog tus xaiv los ntawm tus kws kho mob.

Tsuas xaiv yuav tsum tau thaum hloov qhov hnyav ntawm tus neeg mob lossis nws txoj kev ua neej. Tsis tas li, qhov ntau npaum li cas ntawm cov tshuaj yog nyob ntawm lub sijhawm ntawm nws txoj kev tswj hwm.

Sab sij huam

Cov kev mob tshwm sim tsis zoo ntawm kev noj cov tshuaj yog hypoglycemia. Nws ua rau qhov tseem ceeb tshaj ntawm cov koob tshuaj ntawm cov tshuaj kwv yees rau cov kev xav tau ntawm tus mob ntshav qab zib. Lub hauv paus mob tshwm sim ua ntej los ntawm cov tsos mob xws li tachycardia, tawm hws ntau dhau, kev tshaib plab, poob siab, txob taus, blanching ntawm daim tawv nqaij. Kev mob ntshav qab zib yog nws tus kheej los ntawm cov tsos mob hauv qab no:

• teeb meem tsis pom kev
• cramps
• qaug zog thiab qaug zog,
• mob taub hau
• hnov li cas txo nyob rau hauv concentration,
• bouts ntawm xeev siab thiab ntuav.

Lub caij nyoog ntev thiab nquag tawm tsam cov ntshav qog ntshav qab zib txhawb kev puas tsuaj rau cov hlab ntshav ntawm lub paj hlwb. Qee zaum nws yuav ua rau neeg tuag taus.

Ib qho tsis haum rau Insulin Lantus yog kev fab tshuaj. Nws yog tsiag ntawv los ntawm edema, tawv nqaij ua pob, arterial hypotension, lossis bronchospasm. Qee qhov xwm txheej, kev tiv thaiv insulin tuaj vim qhov tshwm sim ntawm cov tshuaj tiv thaiv tsim nyog hauv tus neeg mob lub cev.

Lwm yam kev phiv hais suav nrog saj cuam tshuam, tsis nco qab noj qab haus huv retinopathy, myalgia, lipoatrophy, thiab lipodystrophy. Edema, mob, liab thiab khaus tshwm sim ntawm thaj chaw txhaj tshuaj. Tom qab lub sijhawm luv luv, cov phiajcim no ploj ntawm lawv tus kheej.

Hloov mus rau Lantus los ntawm lwm hom tshuaj insulin

Yog hais tias tus neeg mob yav dhau los siv tshuaj ntawm qhov siab thiab nruab nrab ntawm kev nqis tes ua, tom qab ntawd hloov mus rau Lantus, kev kho tshuaj ntawm cov tshuaj insulin tseem ceeb yog qhov tsim nyog. Yuav tsum tau tshuaj xyuas kom zoo nrog.

Thaum ob-lub sij hawm txhaj tshuaj ntawm basal insulin (NPH) raug hloov pauv mus rau kev txhaj tshuaj ib zaug ntawm Lantus, qhov koob tshuaj ntawm thawj zaug poob qis txog 20-30%. Qhov no yog ua thaum thawj 20 hnub ntawm kev kho. Qhov no yuav pab tiv thaiv kom tsis txhob muaj ntshav qab zib thaum hmo ntuj thiab sawv ntxov. Hauv qhov no, lub koob tshuaj tau muab ua ntej noj mov tau nce siab. Tom qab 2-3 lub lis piam, kho cov nqi ntawm cov tshuaj yog nqa tawm ntawm tus kheej rau txhua tus neeg mob.

Hauv lub cev qee cov neeg mob, cov tshuaj tiv thaiv rau tib neeg cov insulin yog tsim tawm. Hauv qhov no, lub cev tiv thaiv kab mob rau Lantus kev txhaj tshuaj hloov pauv. Nws kuj tseem yuav tsum tau rov tshuaj dua.

Lantus: daim ntawv tso tawm

Xantus - Cov Insulin uas tau tso tawm rau hauv qhov kev daws teebmeem rau kev tswj hwm subcutaneous.

Lub npe thoob ntiaj teb: insulin glargine.

Cov tshuaj tau tsim los ntawm Sanofi-Aventis. Muaj nyob hauv daim ntawv cartridges rau OptiSet, OptiKlik syringe cwjmem thiab OptiSet thiab SoloStar cov ntawv pov tseg.

Cov tshuaj uas muaj cov npe sib txawv tsis txawv hauv cov tshuaj sib txuam, cov cuab yeej muaj zog, qhia txog kev kho mob thiab contraindications .

Hauv Lavxias, Lantus SoloStar tau dav. Cov neeg tsim khoom - German ceg ntawm lub tuam txhab Sanofi (Sanofi-Aventis Deutschland), nyob hauv Frankfurt ntawm Main thiab ZAO "Sanofi-Aventis Vostok" los ntawm Russia (Oryol Oblast).

1 ml ntawm LantusSoloStar daws muaj 3.638 mg (100 PIECES) ntawm cov tshuaj insulin glargine thiab cov koom haum pabcuam: 2.7 mg ntawm metacresol, 20 mg ntawm glycerol, 30 μg ntawm zinc, sodium hydroxide thiab hydrochloric acid - txog pH 4.0, dej rau kev txhaj tshuaj.

Qhia txog kev kho mob

Cov tshuaj yog tawm rau cov ntshav qab zib, uas yuav tsum tau kho nrog insulin. Lantus SoloStar yog siv rau cov neeg laus, cov tub ntxhais hluas thiab cov menyuam yaus txog ob xyoos. Raws li cov lus qhia soj ntsuam, Lantus yog siv thaum cev xeeb tub thiab thaum lactation.

Cov kev siv thiab kev ua haujlwm ntawm cov tshuaj Lantus SoloStar hauv cov menyuam yaus txij thaum 2 txog 6 xyoo raug pom tseeb tseeb. Hauv cov ntshav qab zib mellitus ntawm thawj hom, qhov profile ntawm qhov concentration ntawm glargine ua ntej kev txhaj tshuaj ntxiv yog zoo ib yam rau cov profile ntawm cov neeg laus. Nrog kev siv Lantus tas li, kev txuam nrog glargine thiab nws cov metabolites tau qhaj ntawv hauv cov menyuam yaus, thiab rau cov neeg laus. Qhov xwm txheej ntawm cov ntshav qog ntshav qab zib tsawg dua nrog isofan insulin. Qhov nruab nrab yog 25 tus neeg mob hauv ib tus neeg mob hauv lub xyoo rau insulin glargine thiab 33 tus neeg mob thaum siv tshuaj insulin isofan.

Thaum cev xeeb tub thiab hauv tomqab Lantus siv nyob rau hauv kev tswj kav glycemic. Nyob rau lub sijhawm no, muaj kev hloov pauv ntawm qhov xav tau ntawm cov tshuaj. Nws yog qhov tsim nyog los kho cov koob tshuaj nyob rau hauv kev saib xyuas ntawm tus neeg mob endocrinologist.

Lantus yog siv rau hom 1 thiab ntshav qab zib hom 2 .

Lantus: ntau npaum

Cov koob tshuaj thiab lub sijhawm ntawm kev muab tshuaj ntawm cov tshuaj raug xaiv ntawm tus kheej. Tus nqi ntawm cov tshuaj insulin glargine nyob ntawm hom mob ntshav qab zib, lub sijhawm mob, qhov hnyav, tus neeg mob noj haus, lub cev noj haus, kev tawm dag zog, thiab ntau lwm yam.

Hauv cov neeg mob uas muaj ntshav qab zib hom 1, qhov feem ntawm cov insulin basal feem ntau yog 40-60% ntawm tag nrho cov nyiaj ntawm qhov ntev thiab luv luv insulin.

Hauv cov neeg mob ntshav qab zib hom ob, kev txhaj tshuaj thawj zaug ntawm insulin glargine yog tus kws kho mob tsis tshaj 10 units, thiab tom qab ntawd hloov kho nws tus kheej hauv qab tswj hwm cov piam thaj sai.

Thaum hloov pauv los ntawm insulin isofan rau insulin glargine, qhov koob tshuaj Lantus yog txo 20% los tiv thaiv qhov tshwm sim ntawm kev mob ntshav qab zib.

Kev sib cuam tshuam txog yeeb tshuaj

Txhim khu cov nyhuv hypoglycemic thiab nce predisposition rau kev txhim kho ntawm hypoglycemia:

• tshuaj sulfa thiab salicylates,
• fibrates
• disopyramids
• propoxyphene
• fluoxetine
• tshuaj tiv thaiv qhov ncauj hypoglycemic.

Weaken hypoglycemic cov nyhuv ntawm cov kua dej:

• glucagon,
• progestogens thiab estrogens,
• tshuaj kho mob
• glucocorticosteroids,
• cov thyroid hormones,
• adrenaline
• atypical tshuaj tiv thaiv kev txom nyem.

Daim ntawv thov rau cov xwm txheej tshwj xeeb thiab cov kab mob ntev

Cov tshuaj Lantus siv rau cev xeeb tub thiab lactation .

Qhov tshwm sim ntawm cov tshuaj Lantus thaum cev xeeb tub yog piav qhia los ntawm kev rov kho dua ntawm tus poj niam lub cev thiab kev hloov pauv ntawm cov keeb kwm hormonal tom qab.

Kev soj ntsuam lub sijhawm ntawm cev xeeb tub tsis tau qhia txog qhov tsis zoo ntawm cov tshuaj insulin rau ntawm qhov xwm txheej ntawm tus menyuam hauv plab, kev ua haujlwm ntawm lub cev, thiab kev noj qab haus huv ntawm tus menyuam mos.

Xav tau cov tshuaj insulin txo qis hauv thawj lub hlis ntawm cev xeeb tub thiab nce me ntsis hauv lub thib ob thiab thib peb. Cov koob tshuaj ntawm cov tshuaj yuav tsum tau muab kho. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus thiab cov ntshav qog ntshav qab zib tuaj yeem tsim kho. Kev tshuaj xyuas nruj ntawm cov chav kawm mob ntshav qab zib hauv kev xeeb tub thiab tom qab yug menyuam yog qhov tsim nyog.

Txoj kev xav tau cov tshuaj insulin tuaj yeem txo qis hauv cov neeg laus vim tias qhov ua haujlwm tsis zoo ntawm lub raum.

Nrog rau daim siab ua haujlwm, vim tias qeeb hauv biotransformation, qhov kev xav tau rau insulin kuj raug txo.

Hauv cov kab mob mus ntev ceev faj qib tswj ntshav piam thaj thiab kev txheeb xyuas ntawm qhov muaj acetone hauv zis.

Cov neeg mob uas siv cov tshuaj hypoglycemic yuav tsum ua raws li kev noj haus, tuaj yeem suav cov khoom noj ntawm carbohydrates hauv cov khoom, paub txog kev noj tshuaj ntawm cov tshuaj insulin thiab nkag siab txog cov cim ntawm hypoglycemia pib.

Dosage daim ntawv

1 ml ntawm kev daws

cov tshuaj nquag - insulin glargine (equimolar units ntawm insulin) 3.6378 mg (100 units)

kev zam rau kev daws nyob rau hauv daim cartridge: metacresol, zinc chloride, glycerin (85%), sodium hydroxide, concentrated hydrochloric acid, dej rau kev txhaj tshuaj.

kev tshem tawm rau cov tshuaj hauv vial: metacresol, polysorbate 20, zinc chloride, glycerin (85%), sodium hydroxide, concentrated hydrochloric acid, dej rau kev txhaj tshuaj.

Transparent tsis muaj kob lossis yuav luag tsis muaj cov kua.

Cov chaw muag tshuaj

Piv rau tib neeg NPH-insulin, ntshav dej insulin ntau hauv cov ntsiab lus noj qab haus huv thiab cov neeg mob ntshav qab zib tom qab kev saib xyuas ntawm insulin glargine qhia tau qeeb dua thiab ua rau lub siab ntev dua, nrog rau qhov tsis muaj lub siab tshaj. Yog li, qhov ntau ntau tau raws li cov ntsiab lus ntawm lub cev ntu ntawm kev ua haujlwm pharmacodynamic ntawm insulin glargine. Daim duab 1 qhia txog cov haujlwm kev ua ntawm insulin glargine thiab NPH-insulin piv rau lub sijhawm. Nrog cov lus qhia ntawm ib zaug ib hnub, qhov sib luag ntawm cov tshuaj insulin glargine nyob rau hauv cov ntshav tau tiav 2-4 hnub tom qab txhaj thawj zaug. Nrog kev tswj hwm intravenous, ib nrab-lub neej ntawm insulin glargine thiab insulin tib neeg tau sib piv.

Tom qab subcutaneous txhaj ntawm Lantus hauv cov neeg mob ntshav qab zib mellitus, insulin glargine yog sai metabolized thaum kawg ntawm polypeptide beta saw los ua ob lub cev siv tshuaj tiv thaiv M1 (21A-Gly-insulin) thiab M2 (21A-Gly-des-30B-Thr insulin). Hauv ntshav, cov kab mob loj ntawm lub voj voog yog cov tshuaj metabolite M1. Kev tso tawm ntawm M1 metabolite nce ntxiv raws li qhov tau hais tseg ntawm Lantus.

Pharmacokinetic thiab pharmacodynamic cov txiaj ntsig tau qhia tias cov nyhuv ntawm subcutaneous txhaj ntawm Lantus feem ntau yog ua raws li kev rho tawm ntawm M1 metabolite. Insulin glargine thiab metabolite M2 tsis pom nyob rau hauv cov neeg mob feem ntau, thaum lawv nrhiav tau, lawv qhov kev tsom xam yog ywj siab ntawm cov tshuaj Lantus.

Hauv kev sim kho mob, kev soj ntsuam ntawm pawg neeg tau tsim los ntawm lub hnub nyoog thiab poj niam txiv neej tsis qhia txog qhov txawv ntawm qhov ua tau zoo thiab kev nyab xeeb ntawm cov neeg mob kho nrog insulin glargine thiab tag nrho cov pej xeem tau kawm.

Pharmacokinetics rau cov menyuam yaus hnub nyoog 2 txog 6 xyoo uas muaj ntshav qab zib hom 1 tau raug soj ntsuam hauv ib qhov kev tshawb fawb soj ntsuam (saib "Pharmacodynamics"). Qhov "tsawg kawg" theem ntawm insulin glargine thiab nws lub ntsiab ntshav plasma metabolites M1 thiab M2 tau ntsuas rau cov menyuam yaus raug kho nrog insulin glargine, thiab nws tau pom tias cov ntshav plasma piv txwv zoo ib yam li cov laus kuaj, cov pov thawj txhawb kev tsub zuj zuj ntawm insulin glargine lossis nws cov metabolites. nrog rau kev tswj hwm ncua ntev yog tsis tuaj.

Insulin glargine yog ib qho piv txwv ntawm tib neeg cov kua dej, tsim kom muaj cov solubility qis ntawm pH nruab nrab. Nws yog kiag li soluble ntawm acidic pH ntawm Lantus® Txhaj Tshuaj (pH 4). Tom qab kev tswj hwm subcutaneous, cov tshuaj acidic yog nruab nrab, ua rau muaj kev tsim cov microprecipitate, los ntawm cov tshuaj insulin glargine txuas ntxiv tso tawm me me, muab ib qho tseem ceeb, tsis pub dawb, kom paub tseeb txog lub sijhawm / sijhawm nrog kev ua haujlwm ntev.

Kev khi rau cov tshuaj insulin: hauv kev tshawb fawb hauv vitro qhia tau tias qhov sib thooj ntawm insulin glargine thiab nws cov metabolites M1 thiab M2 rau tib neeg cov tshuaj insulin yog tib yam rau tib neeg cov insulin.

IGF-1 receptor khi: qhov sib thooj ntawm insulin glargine rau tib neeg IGF-1 receptor yog kwv yees li 5-8 npaug ntau dua li ntawm tib neeg ntawm insulin (tab sis kwv yees li 70-80 npaug qis dua IGF-1), thaum M1 metabolites. thiab M2 khi rau IGF-1 receptor nrog kev sib txuam me ntsis piv rau tib neeg cov insulin.

Tag nrho cov tshuaj tua kab mob ntawm cov tshuaj insulin (insulin glargine thiab nws cov metabolites), txiav txim siab hauv cov neeg mob ntshav qab zib hom ntshav qab zib, tsawg tshaj li qhov yuav tsum tau ua rau ib nrab cov lus teb tshaj plaws los ntawm kev ntes ntawm IGF-1 receptor thiab tom qab ua kom muaj cov kab mob rau txoj kev ua kom cov kab mob ua rau muaj IGF-1 receptor. Cov. Kev tawm dag zog lub zog ntawm endogenous IGF-1 tuaj yeem ua kom cov kab mob ntawm txoj kev loj hlob ntawm txoj kev loj hlob, txawm li cas los xij, kev kho mob ntau yam tau txiav txim siab thaum lub sij hawm kho mob insulin, suav nrog kev kho Lantus, nws qis dua qhov kev siv tshuaj pharmacological xav tau kom ua IGF-1 txoj kev.

Kev ua haujlwm thawj zaug ntawm insulin, suav nrog insulin glargine, yog tswj kev metabolism hauv qabzib. Cov tshuaj insulin thiab nws cov kab mob sib txig txo cov ntshav qabzib ntau ntau ntxiv los ntawm kev nce ntxiv cov piam thaj hauv cov ntaub so ntswg, tshwj xeeb tshaj yog cov leeg pob txha thiab adipose cov nqaij, zoo li los ntawm kev tsim cov piam thaj hauv siab. Cov tshuaj Insulin muab cov lipolysis hauv adipocytes, inhibits proteolysis thiab txhim kho cov protein synthesis. Cov kev tshawb fawb soj ntsuam thiab pharmacological tau qhia tias kev muab cov tshuaj insulin glargine thiab tib neeg cov tshuaj insulin yog qhov sib npaug thaum muab rau tib zaug. Ib yam li txhua yam insulins, kev tawm dag zog thiab lwm yam tuaj yeem cuam tshuam lub sijhawm ntawm kev ua ntawm insulin glargine.

Hauv cov kev tshawb fawb siv euglycemic clamp hauv kev noj qab haus huv tuaj pab dawb thiab cov neeg mob uas muaj hom 1 ntshav qab zib mellitus, qhov kev txiav txim ntawm subcutaneously txhaj tshuaj insulin glargine tau qeeb qeeb dua tib neeg NPH insulin, cov nyhuv ntawm insulin glargine tau zoo thiab tsis tiav, nws lub sijhawm ntev dua.

Sijhawm (xuab moos) elapsed tom qab txhaj subcutaneous

Xaus kev soj ntsuam lub sijhawm

* tau txhais tias yog cov piam thaj qhia txog ntshav qab zib kom ntshav txhawm rau ib qib (ib teev ntawm ib nrab).

Cov kev ua ntev ntev ntawm subcutaneous insulin glargine cuam tshuam ncaj qha rau nws txoj kev nqus qeeb, uas tso cai rau cov tshuaj siv ib hnub ib zaug.Hauv cov tib neeg sib txawv thiab hauv tib tus neeg, lub sijhawm ntawm kev ua ntawm insulin thiab nws cov analogues, xws li insulin glargine, tuaj yeem sib txawv.

Hauv qhov kev tshawb fawb soj ntsuam, cov tsos mob ntawm lub qog ntshav qab zib lossis cov cim ntawm kev tiv thaiv kev tiv thaiv hormonal hauv cov neeg ua haujlwm noj qab haus huv thiab nyob rau cov neeg mob ntshav qab zib hom 1 tau zoo ib yam tom qab kev tso ntshav tshuaj insulin glargine thiab insulin tib neeg.

Lantus: koob txhaj tshuaj cwj mem - cov xwm txheej ntawm kev siv thiab cia

Cov tshuaj yuav tsum muab cia rau hauv tub yees, tab sis kom deb ntawm lub taub yees txias. Cia kub - 4–8 ° C. Daim duab xaum xim yog cia rau hauv chav tsev txog li ib teev ua ntej siv, thiab tom qab siv tas muab cia rau sab nraum lub tub yees, tab sis tsis nyob rau hauv tshav ntuj ncaj qha thiab tsis nyob ze cov khoom siv cua sov.

Txee lub neej ntawm yeeb tshuaj 3 xyoos .

SoloStar kov yog pov tseg thiab siv tsis tau rov qab.

Sterile koob txhaj tshaj SoloStar koob txhaj tshuaj yog hloov ua ntej txhua qhov kev txhaj tshuaj insulin, thiab tom qab ntawd tshem tawm thiab muab pov tseg.

Tus nqi ntawm cov xwj xem hluav taws xob

Lantus tau faib tawm los ntawm cov khw muag tshuaj nrog cov tshuaj noj. Cov neeg mob ntshav qab zib tau txais insulin dawb xwb. Txawm li cas los xij, cov analogues uas muaj nyob ntawm cov tshuaj dawb tau raug sau tseg. Nws tsis yog ib txwm ua li ntawd cov insulin uas tus neeg mob siv .

Tus nqi ntawm cov tshuaj Lantus SoloStar (100 IU / ml 3 ml No. 5) hauv cov chaw muag tshuaj hauv Moscow thaum Lub Xya Hli 2017 kwv yees los ntawm 2810 txog 4276 rubles rau ib pob.

3 ml cartridges thiab SoloStar syringe cwjmem

1 ml ntawm cov tshuaj muaj:

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), dej rau kev txhaj tshuaj.

1 ml ntawm cov tshuaj muaj:

cov tshuaj nquag: insulin glargine - 3.6378 mg, uas sib raug rau 100 PIECES ntawm tib neeg cov tshuaj insulin.

kev tshem tawm: m-cresol, zinc chloride, glycerin (85%) (E422), sodium hydroxide (E524), concentrated hydrochloric acid (E507), polysorbate 20, dej rau kev txhaj tshuaj.

Cov tshuaj insulin glargine tau los ntawm kev rov ua kom tiav ntawm cov kab mob DNA ntawm hom Escherichia coli.

ntshiab, tsis muaj kob.

Cov tshuaj sib cuam tshuam

Tus nab npawb ntawm cov khoom cuam tshuam rau cov metabolism hauv qabzib thiab yuav tsum tsim kom muaj kev kho kom haum ntawm insulin glargine.

Cov yeeb tshuaj uas tuaj yeem txhim kho cov piam thaj hauv kev kho ntshav hauv cov ntshav thiab ua rau muaj kev txo qis rau cov ntshav qab zib hauv lub cev muaj xws li cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, angiotensin-hloov enzyme inhibitors (ACEs), disopyramides, fibrates, fluoxetine, monoamine oxidase inhibitors (MAOs), pentoxifylilides, propylene sulfides thiab propylene.

Cov tshuaj uas yuav ua rau cov ntshav qabzib tsawg nyob rau hauv cov ntshav suav nrog corticosteroid hormones, danazole, diazoxide, diuretics, glucagon, isoniazid, estrogens thiab progestogens, phenothiazine derivatives, somatropin, sympathomimetics (e.g. epinephrine (adrenaline), salbutamolide, , atypical tshuaj tiv thaiv kev ua kom tsis haum (xws li, clozapine thiab olanzapine) thiab cov tshuaj tiv thaiv kab mob tiv thaiv kab mob.

Beta-blockers, clonidine, lithium ntsev thiab dej cawv tuaj yeem ob qho kev txhim kho thiab ua kom cov ntshav tsis haum ntawm cov tshuaj insulin hauv cov ntshav. Pentamidine tuaj yeem ua rau hypoglycemia, qee zaum tom qab los ntawm hyperglycemia.

Tsis tas li ntawd, nyob rau hauv kev cuam tshuam ntawm cov tshuaj sympatolytic xws li β-blockers, clonidine, guanethidine thiab reserpine, cov cim ntawm adrenergic counterregulation tuaj yeem mob me lossis tsis tuaj.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Kev daws rau sc administration pob tshab, tsis muaj xim lossis yuav luag tsis muaj xim.

Cov muaj mob: metacresol (m-cresol), zinc chloride, glycerol (85%), sodium hydroxide, hydrochloric acid, dej d / i.

3 ml - iav tsis muaj kob iav (5) - contour cell ntim (1) - ntim cov duab los qhia.
3 ml - iav tsis muaj kob (1) - OptiSet syringe cwjmem (5) - cov duab los qhia.
3 ml - iav tsis muaj kob (daim 1) - OptiClick cartridge systems (5) - pob cov duab los qhia.

Cov ntawv tshaj tawm thiab ntim khoom

Kev daws rau subcutaneous saib xyuas ntawm 100 PIECES / ml

3 ml ntawm kev daws rau hauv daim cartridge ntawm pob tshab, tsis muaj kob. Lub pob txha taub tau ntim rau ntawm ib sab nrog lub bromobutyl nres thiab crimped nrog txhuas hau, ntawm qhov tod tes nrog bromobutyl plunger.

Ntawm 5 daim cartridges hauv cov hlwv ntsej muag ntim tawm los ntawm ib zaj duab xis ntawm polyvinyl chloride thiab txhuas ntawv ci.

Rau 1 blister sawb ntim ua ke nrog cov lus qhia rau kev siv tshuaj hauv xeev thiab Lavxias lus, muab tso rau hauv lub thawv ntawv thawv.

Kev daws rau kev txhaj tshuaj subcutaneous 100 PIECES / ml

10 ml ntawm kev daws teeb meem hauv cov fwj pob tshab, xim tsis muaj iav, corked nrog chlorobutyl nres thiab dov nrog txhuas hau nrog tiv thaiv kaus mom ua los ntawm polypropylene.

Rau 1 lub raj mis, ua ke nrog cov lus qhia rau kev siv tshuaj kho mob hauv lub xeev thiab Lavxias lus, muab tso rau hauv lub thawv ntawv thawv.

Cia rau cov neeg mob

Khaws ntawm qhov kub ntawm 2 txog 8 ° C hauv qhov chaw tsaus.

Tsis khov! Khaws tsis ncav cuag ntawm cov menyuam yaus!

Tom qab siv thawj zaug, daim cartridge uas tau nruab rau hauv qhov kov tau siv tau rau 4 lub lis piam thiab khaws cia ntawm qhov kub tsis tshaj 25 ° C (tab sis tsis tso rau hauv tub yees).

Tom qab qhib lub raj mis, cov tshuaj no tuaj yeem siv rau 4 lub lis piam thiab khaws cia ntawm qhov kub tsis dhau 25 ° C (tab sis tsis nyob hauv tub yees).

Txee lub neej

2 xyoos (fwj), 3 xyoos (cartridge).

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Lantus yog ib qho ntawm thawj qhov tsis muaj kab zauv ntawm tib neeg cov tshuaj insulin. Tau los ntawm kev hloov cov amino acid asparagine nrog glycine ntawm txoj hauj lwm 21st ntawm txoj saw A thiab ntxiv ob lub arginine amino acids hauv cov saw B mus rau lub davhlau ya nyob twg amino acid. Cov tshuaj no yog tsim los ntawm kev lag luam tshuaj Fabkis loj - Sanofi-Aventis. Hauv qhov kev tshawb fawb ntau, nws tau ua pov thawj tias insulin Lantus tsis tsuas yog txo cov kev mob ntshav qab zib tsawg dua piv nrog cov tshuaj NPH, tab sis tseem txhim kho cov metabolism hauv metabolism. Hauv qab no yog cov lus qhia luv luv rau kev siv thiab tshuaj xyuas cov neeg mob ntshav qab zib.

Cov tshuaj nquag ntawm Lantus yog cov tshuaj insulin glargine. Nws kis tau los ntawm kev rov ua dua caj ces siv k-12 leeg kab ntawm cov kab mob Escherichia coli. Hauv qhov nruab nrab nruab nrab, nws yog me ntsis soluble, nyob rau hauv nruab nrab acidic nws yaj nrog kev tsim ntawm microprecipitate, uas tas li thiab maj mam tso cov kua dej. Vim tias qhov no, Lantus tau muaj ib cov profile ua haujlwm ntev txog 24 teev.

Lub ntsiab pharmacological lub zog:

• Qeeb qeeb adsorption thiab kev txiav txim siab tsis kawg hauv 24 teev.
• Kev txhawb nqa ntawm proteolysis thiab lipolysis hauv adipocytes.
• Cov nquag tivthaiv khi rau cov tshuaj insulin 5-8 zaug ntau dua.
• Cov kev cai ntawm cov piam thaj hauv cov ntshav, kev txwv tsis pub muaj cov kua nplaum tsim tawm hauv lub siab.

Hauv 1 ml Lantus Solostar muaj:

• 3.6378 mg ntawm insulin glargine (hauv 100 IU ntawm tib neeg cov tshuaj insulin),
• 85% glycerol
• dej rau kev txhaj tshuaj
• hydrochloric concentrated acid,
• m-cresol thiab sodium hydroxide.

Cov Ntawv Piav Tshuaj

Cov insulin ntev ua yeeb yam Lantus muaj lub ntsiab lus tseem ceeb - glargine, uas tau sib txuas los ntawm kab mob ntawm cov kab mob Escherichia los ntawm kev rov ua kom zoo dua ntawm nws cov DNA. Ntxiv nrog rau glargine, hauv Lantus muaj ntau tshaj tawm:

• metacresol
• zinc tshuaj dawb
• sodium hydroxide
• glycerol
• hydrochloric acid
• dej.

Lantus tau qhia hauv qab daim tawv nqaij, qhov twg, vim yog kev tshem tawm cov kua qaub ntawm cov tshuaj tiv thaiv, qhov hu ua microprecipitate yog tsim: los ntawm lawv, glargine yuav maj mam tawm dua lwm zaus, ua yeeb yam rau tus neeg maj mam thiab kwv yees tau.

Glargine khi rau cov tshuaj insulin kom zoo li endogenous tib neeg cov insulin, uas ua rau lawv cov kev ua haujlwm lom neeg zoo sib xws. Ib yam li lwm cov tshuaj zoo sib xws, Lantus koom nrog kev tswj hwm cov piam thaj metabolism, txo nws cov nyiaj hauv cov ntshav thiab pab cov ntaub so ntswg zoo ib yam li cov leeg thiab cov rog kom nqus nws zoo dua. Ntxiv mus, glargine qeeb ua kom cov suab thaj hauv lub siab, ua rau tib lub sijhawm ua tiav cov protein.

Ua lub cev ntev ntev rau cov kua dej, Lantus maj mam nqus mus rau hauv cov ntshav los ntawm cov rog subcutaneous, uas ua rau cov kev xav tau siv nws tsis ntau tshaj ib zaug ib hnub.

Qhov nruab nrab, tom qab kev txhaj tshuaj, glargine pib nws txoj haujlwm tom qab ib teev, txuas ntxiv ua haujlwm txhua hnub (qee zaum ntev dua rau ob peb teev). Feem ntau, qhov ua tau zoo thiab lub sijhawm ntawm Lantus qhov kev txiav txim ncaj qha nyob ntawm txhua kis ntawm ib tus neeg.

Siv thaum cev xeeb tub

Zoo li txhua yam tshuaj zoo sib xws, Lantus yuav tsum tau siv nrog kev saib xyuas ntxiv thaum cev xeeb tub, txawm hais tias kev sim tshuaj tsis tau qhia tawm qhov kev puas tsuaj uas tuaj yeem ua rau menyuam hauv plab. Qhov ua tau zoo ntawm cov cuab yeej no tsis txawv ntawm nws lwm cov analogues, uas tau siv los ntawm cov poj niam cev xeeb tub muaj kev mob ntshav qab zib. Txawm li cas los xij, qhov no tsis tshem tawm qhov xav tau los sau tshuaj Lantus nrog txhua qhov tseeb thiab tswj cov ntshav qab zib kom txog thaum xa khoom. Qhov kev xav tau ntawm tus poj niam lub cev rau insulin thaum cev xeeb tub feem ntau qis dua nyob rau thawj peb lub hlis, tab sis tom qab ntawd maj mam nce ntxiv thaum lub sijhawm thib ob thiab thib peb lub tsaj. Qeb no rov zoo li qub tom qab yug menyuam, tab sis qee zaum muaj qhov txo qis ntawm lub qog ntshav qab zib. Thaum lub sijhawm pub mis tom qab ntawd, nws yuav tsim nyog kho los kho lub koob tshuaj Lantus.

Kev cuam tshuam ntawm Lantus nrog lwm cov tshuaj thiab tshuaj yeeb dej caw

Cov tshuaj muaj ntau yam tuaj yeem txhim kho lub hypoglycemic cov cuab yeej ntawm Lantus thiab ua kom nws tsis muaj zog, vim li no, txhawm rau kho raws caij nyoog, koj yuav tsum paub txhua yam kev xaiv ua tau. Yog tias peb tham txog kev ua kom nrov nrov, ces cov tshuaj no tuaj yeem raug ntaus nqi:

• hypoglycemic tshuaj noj qhov ncauj,
• disopyramids
• fluoxetine
• pentoxifylline
• muaj ntsev,
• fibrates
• monoamine oxidase inhibitors
• propoxyphene
• sulfonamide antimicrobial tus neeg sawv cev.

Lwm yam tshuaj muaj peev xwm, ntawm qhov tsis sib xws, tsis muaj zog cov nyhuv uas tsim los ntawm Lantus, uas yuav tsum tau tsim kho me ntsis ntawm nws cov koob tshuaj. Cov tshuaj muaj xws li cov hauv qab no:

• danazol
• txawv diuretics
• isoniazid
• tshuaj tiv thaiv cev xeeb tub,
• epinephrine, salbutamol, terbutaline,
• diazoxide
• glucagon,
• phenothiazine,
• kev loj hlob lawm,
• cov thyroid hormones,
• tshuaj thaiv qhov ncauj
• protease inhibitors.

Nws tseem muaj cov tshuaj uas tuaj yeem cuam tshuam ob npaug ntawm cov cuab yeej hypoglycemic ntawm glargine, thiab cov no suav nrog beta-blockers, lithium ntsev, cawv, clonidine, pentamidine, guanethidine, reserpine. Nws yuav tsum raug sau tseg tias qhov kawg ob tuaj yeem "nplua" rau cov cim ntawm kev yuav mob ntshav qab zib, uas yog li ua rau muaj kev phom sij ntxiv rau cov ntshav qab zib.

Dab tsi ntxiv uas koj yuav tsum paub txog Lantus?

Txij li Lantus yog qhov ntev tshaj plaws-ua yeeb yam insulin, nws tsis tuaj yeem siv nws raws li txhais tau tias kev sib txuas ntawm cov ntshav qab zib ketoacidosis. Tsis tas li ntawd, kev ua haujlwm tsis zoo rau lub raum (tshwj xeeb tshaj yog rau cov neeg laus) ua rau muaj kev txo qis ntawm cov ntshav qab zib ntawm cov ntshav qab zib, uas yog vim li cas lawv qhov kev xav tau rau insulin tuaj yeem txo qis. Tib yam siv rau cov neeg uas muaj lub siab tsis ua haujlwm, vim tias lawv poob qhov kev ua haujlwm ntawm gluconeogenesis txheej txheem thiab insulin transformation poob nws qhov qeeb.

Tus kws kho mob uas tuaj koom yuav tsum nco ntsoov tias yog tswj ntshav qab zib cov ntshav tau tsis txaus siv, lossis yog tias tus neeg mob lub cev muaj mob hyperglycemia lossis ntshav qab zib tsawg, yuav tsum muaj qee yam kev ntsuas ua ntej yuav kho cov tshuaj Lantus ntau npaum li cas. Ntawm no yog ua:

• Nco ntsoov tias tus neeg mob ua raws li txheej txheem kho mob yav tas los,
• Nco ntsoov tias tus neeg mob tau txhaj tshuaj glargine ntawm qhov chaw nruj me ntsis ntawm lub cev,
• kuaj xyuas tus neeg mob kom ua raws li txhua qhov kev ntsuas tsim nyog thaum qhia Lantus hauv qab daim tawv nqaij.

Lub sijhawm ntawm kev txhim kho hypoglycemia hauv tus neeg mob cuam tshuam nrog cov ntawv ntawm kev ua ntawm cov tshuaj insulin-uas nws siv. Qhov no txhais tau hais tias yog tias lub caij nyoog ntev-insulin nkag mus rau hauv cov ntshav tom qab tshaj li qhov xav, qhov kev pheej hmoo ntawm ntshav qabzib thaum sawv ntxov yuav nce ntxiv, thaum muaj feem ntau ntawm hmo ntuj hypoglycemia poob qis. Nws yuav tsum nco ntsoov tias kev them nyiaj rau tus neeg mob hypoglycemic lub xeev nyob rau hauv cov ntaub ntawv ntawm Lantus yuav siv sijhawm ntev dua vim yog cov profile ntev ntawm nws cov kev ua.

Muaj ntau tus kabmob uas tseem mob ntshav qab zib mentsis tuaj yeem ua rau muaj teebmeem kev noj qab haus huv lossis tsis tuaj yeem ua rau raug mob tau. Cov no suav nrog vascular stenosis ntawm lub paj hlwb lossis cov hlab ntsha txhaws, nrog rau cov kev tawm suab tau zoo. Nws yuav tsum raug sau tseg tias hauv qee pab pawg ntawm cov tib neeg, cov cim qhia tias yuav ua rau hypoglycemia yuav mob me lossis tsis tuaj ib lub sijhawm. Ntawm cov pawg tseem ceeb yog cov hauv qab no:

• cov neeg mob uas tau txais kev hloov kho cov ntshav qab zib
• cov neeg uas muaj kev hloov maj mam txhim kho hypoglycemia,
• neeg laus
• cov neeg mob yav tas los siv insulin ntawm tsiaj keeb kwm,
• cov neeg mob uas muaj keeb kwm ntev los ntshav qab zib,
• cov neeg muaj kev puas hlwb los ntawm kev mob hlwb lossis mob hlwb.

Ib qho ntawm cov laj thawj no tuaj yeem ua rau muaj ntshav qab zib ntau (nce mus txog tsaus muag) ua ntej cov ntshav qab zib tau lees paub nws cov kev hem thawj. Muaj lwm yam, muaj nyob rau ntawm uas yuav tsum tau tus neeg mob kom zoo saib xyuas nws tus mob thiab kho qhov ntau npaum li cas ntawm Lantus. Ntxiv rau cov kab mob ntshav qab zib uas tsis pom kev zoo, cov no suav nrog qhov muaj feem ua rau lub siab txhawm rau txhawm rau hloov pauv, hloov thaj chaw txhaj tshuaj, ua si lub cev ntau dhau, ua txhaum cai ntawm kev noj haus, haus cawv, ntuav lossis raws plab, nrog rau qee qhov kev cuam tshuam nyob hauv cov kab mob endocrine.

Muab cov tshuaj insulin kom zoo

Nws yog ib qho tsim nyog yuav tsum khaws cov Lantus cartridges ntawm qhov kub ntawm ob txog yim degrees Celsius, thiab lub tub yees yog qhov zoo tshaj plaws rau qhov no, tab sis kev saib xyuas yuav tsum tau suav tias kev ntim khoom tsis chwv lub freezer lossis khoom noj khov. Nws yog tsis yooj yim sua kom supercool cov tshuaj, ntxiv rau nws nthuav tawm ncaj qha tshav ntuj lossis cia me nyuam nkag tau.

Hais ncaj qha, daim ntawv xaum xaum hluav taws xob rau hauv lub thawv uas muab tso rau hauv yuav tsum muab tso rau ntawm chav tsev qhov chaw sov li ob peb teev ua ntej siv. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias nrog Lantus, twb tau sau rau hauv rab koob txhaj tshuaj, qhov siab tshaj plaws ntawm lub neej yog txo mus rau ib hlis, thiab los saib xyuas qhov no tom qab siv thawj zaug nws zoo dua rau hnub tim ntawm qhov txhaj thawj ntawm cov ntawv sau. Txhawm rau kom tsis txhob muaj kev pheej hmoo ntawm kev kis tus kab mob, tsuas yog ib tus neeg mob yuav tsum siv rab koob txhaj tshuaj.

KIS DAWB RAU LUAJ! THIAB SAIB XYUAS KOJ TUS KHEEJ, KOJ TXHUA TUS KHEEJ PAUB TXOG DIAB?

Sijhawm Txwv: 0

Kev mus los (txoj hauj lwm cov naj npawb xwb)

0 ntawm 7 cov haujlwm tiav

YUAV UA LI CAS PIB? Kuv paub tseeb tias koj! Nws yuav nthuav heev)))

Koj twb dhau txoj kev sim ua ntej lawm. Koj tsis tuaj yeem pib nws ntxiv.

Koj yuav tsum nkag mus lossis sau npe nkag mus txhawm rau pib ntsuas.

Koj yuav tsum ua tiav cov kev xeem hauv qab no los pib qhov no:

Cov lus teb yog: 0 ntawm 7

Koj tau 0 tawm ntawm 0 ntsiab lus (0)

Ua tsaug rau koj lub sijhawm! Nov yog koj tau!

1. Nrog lus teb
2. Nrog saib cim

Lub npe “ntshav qab zib” txhais tau li cas?

Yam tshuaj dab tsi tsis txaus rau cov ntshav qab zib hom 1?

Cov tsos mob twg yog TSIS TAU siv rau ntshav qab zib?

Tus thawj coj kev tswj hwm

Lantus® yuav tsum tau tswj hwm subcutaneously. Yuav tsum tsis txhob muab lub lantus® tso ncaj nruab nrog txoj leeg. Lub caij nyoog ntev ua haujlwm ntawm Lantus yog vim nws qhov kev taw qhia rau hauv cov rog subcutaneous. Kev tswj hwm ntawm cov tshuaj subcutaneous li niaj zaus tuaj yeem ua rau mob ntshav qab zib heev. Tsis muaj qhov sib txawv hauv qhov chaw kho mob hauv cov ntshav insulin lossis cov piam thaj tom qab kev tswj hwm ntawm Lantus mus rau lub plab phab ntsa, deltoid cov leeg, lossis ncej puab.Nws yog ib qho tsim nyog yuav tsum hloov chaw txhaj tshuaj nyob rau thaj chaw ib zaug. Lub lantus® yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulin lossis diluted. Kev sib xyaw thiab kev zom zaws tuaj yeem hloov kho lub sijhawm / kev ua ub no; kev sib xyaw tuaj yeem ua rau dej nag.

Kev siv cwj mem raug siv

Ua ntej siv SoloStar, koj yuav tsum ua tib zoo nyeem cov lus qhia rau kev siv, uas tau piav qhia hauv nplooj ntawv.

Kev tswj hwm tsis raug cai ntawm cov tshuaj

Cov neeg muaj tus mob no tau tshaj tawm thaum cov tshuaj tsis meej pem nrog lwm cov insulins, tshwj xeeb, luv luv ua haujlwm insulins tau txais kev tswj hwm tsis txhob siv cov glargine los ntawm kev ua yuam kev. Ua ntej txhua txoj kev txhaj tshuaj, nws yog ib qho tsim nyog yuav tsum kuaj cov tshuaj insulin kom tsis txhob muaj kev kub ntxhov ntawm insulin glargine thiab lwm yam insulins.

Kev sib xyaw ntawm Lantus nrog pioglitazone

Cov kab mob hauv lub plawv tsis ua haujlwm tau paub thaum pioglitazone tau siv nrog kev siv tshuaj insulin, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj kev pheej hmoo rau lub plawv tsis ua haujlwm. Qhov no yuav tsum nco ntsoov thaum sau cia ua ke nrog pioglitazone thiab Lantus. Yog tias kev sib koom ua ke tau kho, tus neeg mob yuav tsum tau soj ntsuam cov cim thiab cov tsos mob ntawm lub plawv tsis ua hauj lwm, hnyav ntxiv, thiab o. Pioglitazone yuav tsum tsis ua mus ntxiv yog tias muaj cov tsos mob ntawm lub plawv tsis zoo.

Cov tshuaj no tsis tuaj yeem sib xyaw nrog lwm cov tshuaj. Nws yog ib qho tseem ceeb tias cov koob txhaj tshuaj tsis muaj kab ke ntawm lwm yam tshuaj.

Lantus solostar Siv hauv cev xeeb tub thiab menyuam yaus

Hauv cov kev tshawb fawb tsiaj, tsis muaj cov ntaub ntawv ncaj qha lossis tsis ncaj rau ntawm cov embryotoxic lossis fetotoxic cov teebmeem ntawm insulin glargine. Txog tam sim no, tsis muaj txheeb cais hais txog kev siv cov tshuaj thaum cev xeeb tub. Muaj pov thawj ntawm kev siv tshuaj Lantus® SoloStar® hauv 100 tus poj niam cev xeeb tub uas muaj ntshav qab zib. Cov chav kawm thiab kev tshwm sim ntawm cev xeeb tub hauv cov neeg mob no tsis txawv ntawm cov poj niam cev xeeb tub uas muaj ntshav qab zib uas tau txais lwm yam tshuaj insulin. Kev teem sij hawm ntawm cov tshuaj Lantus® SoloStar® hauv cov poj niam cev xeeb tub yuav tsum tau ua nrog ceev faj. Yuav tsum tau ua tib zoo soj ntsuam ntawm cov ntshav qabzib feem ntau. Rau cov neeg mob uas muaj ntshav qab zib ua ntej los yog mob hauv plab, nws yog ib qho tseem ceeb kom tswj tau glycemic tswj thoob plaws thaum cev xeeb tub. Qhov kev xav tau rau insulin tuaj yeem txo qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce ntxiv thaum lub sijhawm thib ob thiab thib peb. Tam sim ntawd tom qab yug los, xav tau cov insulin tsawg zuj zus (qhov kev pheej hmoo ntawm cov ntshav qog ntshav nce siab). Nyob rau cov xwm txheej no, kev saib xyuas kev saib xyuas ntawm cov ntshav qabzib hauv cov ntshav yog qhov tseem ceeb. Hauv cov poj niam thaum lub sij hawm pub mis niam, nws yuav tsim nyog los kho cov tshuaj ntau npaum li cas ntawm cov tshuaj insulin thiab kev noj haus.

Dosage Lantus Solostar

P / c. Cov neeg loj thiab me nyuam muaj hnub nyoog tshaj 6 xyoo. Lantus® SoloStar® yuav tsum siv tsuas yog s / c ib hnub ib zaug, ib txwm tib lub sijhawm. Lantus® SoloStar® yuav tsum tau txhaj rau cov roj ntsha hauv plab, xub pwg lossis lub duav. Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv nrog txhua qhov kev txhaj tshuaj tshiab hauv thaj chaw pom zoo rau kev coj ua haujlwm ntawm cov tshuaj. Cov koob tshuaj ntawm cov tshuaj Lantus® SoloStar® thiab lub sijhawm ntawm hnub rau nws txoj kev tswj hwm yog xaiv tau ib tus kheej. Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, Lantus® SoloStar® tuaj yeem siv ob qho tib si li monotherapy thiab hauv kev sib xyaw nrog lwm cov tshuaj hypoglycemic. Hloov los ntawm kev kho mob nrog lwm cov tshuaj hypoglycemic mus rau Lantus® SoloStar® Thaum hloov cov tshuaj nruab nrab lossis ntev ntev los kho cov tshuaj tua kab mob nrog kev kho mob nrog Lantus® SoloStar®, nws yuav tsim nyog kho qhov tshuaj txhua hnub ntawm cov tshuaj insal basal, thiab nws kuj yuav tsim nyog hloov cov tshuaj concomitant antidiabetic (koob tshuaj thiab cov kev coj noj coj ua ntawm kev siv tshuaj insulins luv luv lossis lawv cov qauv tshuaj lossis koob tshuaj ntawm qhov ncauj tshuaj qog ntshav). Thaum hloov cov neeg mob los ntawm kev tswj hwm cov tshuaj insulin-isophan ob zaug thaum nruab hnub rau ib leeg kev tswj hwm ntawm Lantus® SoloStar® kev npaj txhawm rau txhawm rau txo qis kev pheej hmoo ntawm hypoglycemia thaum hmo ntuj thiab thaum sawv ntxov ntxov, qhov kev noj tshuaj txhua hnub ntawm basal insulin yuav tsum txo qis 20-30% hauv thawj lub lis piam ntawm kev kho mob.Nyob rau lub sijhawm no, qhov kev txo lub koob tshuaj, tsawg kawg ntawm ib feem, yuav tsum tau them nyiaj rau los ntawm kev nce ntxiv ntawm cov tshuaj insulin luv luv, tom qab ntawd los ntawm cov tib neeg kev txhim kho qhov tshuaj ntau dua. Lantus® SoloStar® yuav tsum tsis txhob sib xyaw nrog lwm cov tshuaj insulin los yog ua kom sib xyaw. Koj yuav tsum paub tseeb tias cov koob txhaj tshuaj tsis muaj cov tshuaj seem ntawm lwm cov tshuaj. Thaum muab sib xyaw los yog zom, qhov profile ntawm insulin glargine yuav hloov lub sijhawm. Kev sib xyaw nrog lwm cov insulins tuaj yeem ua rau dej nag. Ib yam li lwm yam tshuaj tiv thaiv kab mob rau tib neeg, cov neeg mob tau txais insulin ntau vim tias muaj cov tshuaj tiv thaiv rau tib neeg cov insulin tuaj yeem muaj qhov nce ntxiv ntawm cov lus teb rau insulin thaum hloov mus rau Lantus® SoloStar®. Hauv kev hloov pauv mus rau Lantus® SoloStar® thiab hauv thawj lub lis piam tom qab nws, ua tib zoo saib xyuas ntshav qabzib thiab, yog tias tsim nyog, kev kho ntawm cov tshuaj insulin rau noj yuav tsum muaj. Nyob rau hauv cov ntaub ntawv ntawm kev txhim kho metabolic kev cai thiab qhov tshwm sim ntau ntxiv nyob rau hauv cov nqaij ua haujlwm nrog insulin, nws yuav tsim nyog los txuas ntxiv rau kev noj tshuaj. Kev hloov kho koob tshuaj kuj tseem xav tau, piv txwv li, thaum hloov tus neeg mob lub cev qhov hnyav, kev ua neej, lub sijhawm ntawm hnub rau kev tswj hwm tshuaj, lossis thaum muaj lwm yam tshwm sim uas ua rau muaj kev cuam tshuam ntau ntxiv rau kev txhim kho hypo- lossis hyperglycemia. Cov tshuaj yuav tsum tsis txhob siv iv. Hauv / hauv kev qhia ntawm cov koob tshuaj ib txwm, npaj rau kev qhia ntawm sc, tuaj yeem ua rau kev txhim kho ntawm cov ntshav qog ntshav qis. Lub sijhawm tiv thaiv ntawm cov tshuaj Lantus® SoloStar® nyob ntawm kev ua kom thaj tsam ntawm thaj chaw ntawm nws lub chaw tswj hwm sc. Cov lus qhia rau kev siv thiab tuav cov ntawv sau ua ntej ntawm SoloStar® koob txhaj tshuaj Ua ntej siv thawj zaug, rab koob xaum yuav tsum tau khaws cia hauv chav tsev li 1-2 teev. Nws yuav tsum siv tsuas yog hais tias qhov kev daws teeb meem yog pob tshab, xim, tsis muaj qhov pom ntawm cov khoom thiab thiab zoo sib xws, cuam tshuam nrog dej. Lub cev tsis siv SoloStar ® cov koob txhaj tshuaj yuav tsum tsis tau siv thiab muab pov tseg. Txhawm rau tiv thaiv kev kis mob, tus cwj mem uas muaj menyuam qhwv ua ntej tsuas yog siv los ntawm ib tus neeg mob thiab yuav tsum tsis txhob hloov mus rau lwm tus. Kev Siv SoloStar® Syringe Cwj mem Ua ntej siv SoloStar® Syringe Cwj mem, ua tib zoo nyeem cov lus qhia siv. Cov ntaub ntawv tseem ceeb ntawm Kev Siv SoloStar® Syringe Cwj mem Ua ntej siv txhua, ua tib zoo muab lub koob tshiab tso rau ntawm rab koob txhaj tshuaj thiab ntsuas kev nyab xeeb. Tsuas siv cov koob uas txuam nrog SoloStar ® yuav tsum siv. Cov kev tiv thaiv tshwj xeeb yuav tsum tau ceev faj kom tsis txhob muaj kev sib tsoo nrog kev siv koob thiab qhov kis tau ntawm kev kis tus kab mob. Txawm li cas los xij koj yuav tsum siv SoloStar® koob txhaj tshuaj yog tias nws puas ntsoog lossis yog koj tsis paub meej tias nws yuav ua haujlwm tau zoo. Nws yog ib txwm tsim nyog yuav tsum muaj SoloStar ® syringe cwj mem thaum koj poob lossis ua rau daim ntawv dhau ntawm SoloStar® koob txhaj tshuaj. Cov Lus Qhia Kev Khaws Cia Cov nqe lus khaws cia yuav tsum muab saib xyuas raws li cov cai khaws cia ntawm SoloStar® Syringe Pen. Yog tias SoloStar® koob txhaj tshuaj yuav tsum tau muab cia rau hauv tub yees, nws yuav tsum tau muab tshem tawm los ntawm qhov ntawd 1-2 teev ua ntej qhov kev txhaj tshuaj, kom cov tshuaj ua rau chav sov. Kev tswj hwm cov tshuaj chine chilled yog qhov mob ntau dua. Kev siv SoloStar® Syringe Pen yuav tsum tau muab rhuav pov tseg. Txoj Haujlwm Kev Siv SoloStar® Syringe Cwj mem yuav tsum muaj kev tiv thaiv los ntawm cov plua plav thiab av. Sab nraud ntawm SoloStar® Syringe Pen tuaj yeem ntxuav los ntawm kev so nws nrog daim ntaub noo.Tsis txhob da dej SoloStar® koob txhaj tshuaj hauv cov kua, yaug lossis ntub nws, vim tias qhov no tuaj yeem ua rau SoloStar® koob txhaj tshuaj. SoloStar ® Syringe Pen xa cov tshuaj insulin kom raug thiab nyab xeeb siv. Nws tseem yuav tsum tau ua tib zoo saib xyuas. Zam zam cov xwm txheej uas ua rau SoloStar ® koob txhaj tshuaj yuav tshwm sim. Yog tias muaj kev xoom xaim uas qhov siv SoloStar® syringe cwj mem ua puas lawm, siv tus cwj mem tshiab. Theem 1. Tshuaj Insulin.Qhov daim ntawv lo ntawm SoloStar® koob txhaj tshuaj yuav tsum raug kuaj xyuas kom paub meej tias nws muaj cov insulin tseeb. Rau Lantus®, SoloStar® koob txhaj tshuaj yog grey nrog lub khawm xiav rau txhaj. Tom qab hle lub hau ntawm cov cwj mem syringe, qhov pom ntawm cov tshuaj insulin hauv nws yog tswj: cov tshuaj insulin yuav tsum muaj pob tshab, tsis muaj xim, tsis muaj cov khoom ua kom pom pom thiab zoo li dej nyob hauv xwm yeem. Theem 2. Txuas siv rab koob Tsuas siv koob nrog SoloStar® koob txhaj tshuaj yuav tsum tau siv. Txog kev txhaj txhua zaus, yuav tsum siv rab koob tshiab tshiab uas tsis huv. Tom qab hle lub hau tawm, rab koob yuav tsum tau muab ntsia kom zoo ntawm daim duab syringe. Theem 3. Ua qhov ntsuas kev nyab xeeb Ua ntej txhua qhov txhaj tshuaj, yuav tsum ntsuas qhov kev nyab xeeb kom paub meej tias cov koob txhaj tshuaj thiab koob ua haujlwm tau zoo thiab cov pa npuas tau tshem tawm. Ntsuas cov koob tshuaj sib npaug rau 2 PIECES. Cov kaus mom uas siv sab nraud thiab sab hauv yuav tsum tau muab tshem tawm. Muab tus cwj mem ntim nrog rab koob tso tawm, maj mam coj mus rhaub cov insulin lub taub hau nrog koj tus ntiv tes kom txhua npuas pa mus rau rab koob. Tag nrho nias lub pob txhaj. Yog tias muaj cov tshuaj insulin rau ntawm qhov kawg ntawm rab koob, qhov no txhais tau tias rab koob xaum thiab rab koob ua hauj lwm zoo. Yog tias cov tshuaj insulin tsis tshwm sim rau ntawm lub ntsis ntawm rab koob, tom qab ntawd cov kauj ruam 3 tuaj yeem rov ua dua kom txog thaum cov insulin tshwm ntawm lub taub ntawm rab koob. Theem 4. Kev xaiv ntau koob Lub koob tshuaj tuaj yeem tsim nrog qhov tseeb ntawm 1 UNIT los ntawm qhov tsawg kawg nkaus siv (1 UNIT) mus txog qhov siab tshaj (80 UNIT). Yog tias nws yuav tsum los qhia qhov tshuaj tshaj li ntawm 80 tus PIECES, yuav tsum txhaj 2 koob los yog ntau dua. Lub koob tshuaj yuav tsum kos npe "0" tom qab kev ntsuas kev nyab xeeb tiav. Tom qab ntawd, cov koob tshuaj tsim nyog tau tsim muaj. Theem 5. Kev tswj hwm.Tus neeg mob yuav tsum paub txog cov txheej txheem txhaj tshuaj los ntawm tus kws kho mob. Lub koob yuav tsum tau muab tso rau hauv qab daim tawv nqaij. Lub pob txhaj tshuaj yuav tsum nias tag nrho. Nws tau tuav hauv txoj haujlwm no rau lwm 10 s kom txog thaum lub koob tau muab tshem tawm. Qhov no ua kom paub tseeb ntawm qhov kev xaiv ntawm xaiv koob tshuaj insulin kiag li. Theem 6. Tshem tawm thiab muab rab koob tso rau tag nrho txhua kis, rab koob tom qab txhua txoj kev txhaj tshuaj yuav tsum tshem tawm thiab muab pov tseg. Qhov no ua kom muaj kev tiv thaiv ntawm kev sib kis thiab / lossis kis tau tus mob, cua nkag mus rau hauv lub thawv rau tshuaj insulin thiab paim ntshav ntawm insulin. Thaum hle thiab pov tseg lub koob, yuav tsum muaj kev tiv thaiv tshwj xeeb. Cov lus qhia txog kev nyab xeeb kev nyab xeeb kom tshem tawm thiab pov tawm rab koob (piv txwv, cov txheej txheem ntawm muab tso rau ntawm lub hau nrog ib txhais tes) yuav tsum tau ua raws li qhov txo qis kev pheej hmoo ntawm kev sib tsoo nrog kev siv rab koob thiab tseem tuaj yeem tiv thaiv kev kis mob. Tom qab tshem rab koob, kaw SoloStar® koob txhaj tshuaj nrog lub hau.

Cov tsos mob: ib qho kev txhaj tshuaj ntau dhau ntawm insulin tuaj yeem ua rau mob ntshav qabzib heev thiab qee zaum ntev, uas tsim kev puas tsuaj rau tus neeg mob lub neej. Kev Kho Mob: Cov kev mob ntshav qab zib tsawg kawg feem ntau yuav nres los ntawm kev noj zaub mov sai sai. Nws yog qhov tsim nyog yuav tsum hloov pauv kev noj tshuaj, tshuaj noj lossis ua haujlwm rau lub cev. Kev mob tshwm sim ntawm cov ntshav khov ntau dua, uas tshwm sim los ntawm kev tsis nco qab, ua kom mob hlwb lossis mob hlwb, yuav tsum tso ntshav tshuaj lossis ntshav tawm ntawm glucagon, nrog rau kev tswj hwm tshuaj ntawm cov tshuaj tov ntawm dextrose (qabzib).Lub sijhawm ntev kom tau cov carbohydrate thiab kev saib xyuas tshwj xeeb yuav tsum tau ua, raws li tom qab pom cov chaw kho mob txhim kho, ib qho kev rov qab los ntawm hypoglycemia yog ua tau.