Yawg Hlob Farmasulin HNP

Farmasulin® N NP thiab Farmasulin® N 30/70 yog kev npaj ntawm tib neeg cov kua dej tau txais los ntawm kev siv cov thev naus laus zis DNA thev naus laus zis. Cov tom kawg muaj tag nrho cov yam ntxwv ntawm cov tshuaj insulin. Cov tshuaj tshwj xeeb ua rau kev tswj hwm cov metabolism hauv cov nqaij. Txo cov ntshav qab zib. Lawv pab txhawm rau txhim kho cov nquag thauj thauj ntawm carbohydrates thiab amino acids rau hauv qhov chaw intracellular, suppressing lipolysis, txhawb lub zog ntawm RNA thiab cov nqaijrog, nrog rau kev ua kom glycogen synthesis. Cov tshuaj ua rau kom muaj cov pa roj ntau ntau rau hauv cov ntshav los ntawm qhov chaw pericellular, uas pab txo qis ntawm diastolic myocardial depolarization uas tshwm sim nrog kev mob plawv thiab ua rau muaj kev cuam tshuam thaum siv digitalis, GCS thiab catecholamines.
Qhov pib ntawm cov nyhuv yog 1 teev tom qab kev tswj hwm ntawm Farmasulin® N NP lossis 30 feeb tom qab kev tswj hwm ntawm Farmasulin® H 30/70. Qhov siab tshaj plaws siab tshaj plaws thiab cov nyhuv kho tau pom ntawm 2 mus rau 8 teev thaum siv Farmasulin® N NP lossis nruab nrab ntawm 1 txog 8.5 teev thaum siv Farmasulin® H 30/70. Lub sijhawm ntawm tswj kev kho lub siab yog 18-20 teev lossis 14-15 teev, raws li.

Kev qhia rau kev siv tshuaj Farmasulin

Mob ntshav qab zib Insulin-tiv thaiv kab mob ntshav qab zib hom (hom I), cov mob ntshav qab zib tsis yog insulin-tiv thaiv ntshav qab zib mellitus (hom II), yog tias nws tsis tuaj yeem ua tiav kev them nqi ntawm tus kab mob nrog kev noj zaub mov noj thiab tshuaj ntawm qhov ncauj hypoglycemic. Txhua yam ntshav qab zib tsis yooj yim los ntawm kev kis kab mob, tsis tuaj yeem kho kab mob tawv nqaij, mob caj dab, hlab plawv tsis txaus nrog txhaws ntswg, rov qab muaj mob, phais mob hauv cov neeg mob ntshav qab zib, mob ntshav qab zib ketoacidosis, precoma thiab coma, tsis kam sulfonylureas, cev xeeb tub lub sijhawm mob ntshav qab zib.

Kev siv cov tshuaj Farmasulin

P / c. Cov koob tshuaj thiab lub sijhawm ntawm kev tswj hwm tau teeb tsa rau txhua tus neeg mob. Cov tshuaj raug rau 1 lossis ntau zaug ib hnub. Lub sijhawm nruab nrab ntawm SC txhaj tshuaj thiab kev pub zaub mov noj yuav tsum tsis pub ntev tshaj 45-60 feeb (tsis pub dhau 30 feeb thaum siv Farmasulin® N 30/70). Kev siv cov tshuaj yuav tsum nrog cov khoom noj tseem ceeb. Thaum txiav txim siab cov calories ntau ntawm cov zaub mov (raws li txoj cai, 1700-3000 calories), nws yuav tsum tau coj los ntawm tus neeg mob lub cev qhov hnyav, nrog rau qhov xwm ntawm nws cov haujlwm. Thaum txiav txim siab thawj koob tshuaj, nws yog qhov yuav tsum tau ua los ntawm qib ntawm kev yoo mov thiab thaum nruab hnub, nrog rau cov qib glucosuria thaum nruab hnub. Hauv kev kwv yees kwv yees ntawm cov tshuaj ntawm ib cov tshuaj, ib qho tuaj yeem ua raws li kev txiav txim siab hauv qab no: yog tias qib glycemia siab tshaj 9 mmol / L, 2–4 IU ntawm cov tshuaj insulin yog qhov xav tau rau kev kho ntawm txhua qhov tom qab 0.45-0.9 mmol / L ntawm cov ntshav qabzib. Qhov kev xaiv kawg ntawm cov koob tshuaj insulin yog ua tiav nyob rau hauv kev tswj hwm ntawm tus mob thoob plaws ntawm tus neeg mob thiab coj mus rau hauv tus account glucosuria thiab glycemia, uas tau pom zoo tiv thaiv keeb kwm yav dhau los ntawm kev siv tshuaj. Feem ntau, cov tshuaj txhua hnub yog 0.5-1.0 IU / kg lub cev qhov hnyav hauv cov laus thiab yuav tsum tsis txhob ntau dua 0.7 IU / kg lub cev qhov hnyav hauv cov menyuam yaus. Hauv cov neeg mob uas muaj lub zog labile ntawm tus kab mob, thaum cev xeeb tub, hauv cov menyuam yaus - kev hloov pauv ntawm cov tshuaj insulin yuav tsum tsis pub tshaj 2 I4 IU ib 1 txhaj.
Kev Txhaj Tshuaj
Koj yuav tsum nco ntsoov tias lub koob txhaj tshuaj siv, qhov kawm tiav ntawm qhov uas sib haum rau cov tshuaj tua kab mob ntawm cov tshuaj insulin. Lub koob txhaj tshuaj ntawm tib lub hom thiab cov khoom lag luam yuav tsum tau siv. Kev mloog tsis txaus thaum siv cov koob txhaj tshuaj yuav ua rau cov tshuaj insulin tsis raug. Qhov kev txhaj tshuaj yog nqa tawm raws li hauv qab no:

1. Ua ntej sau cov tshuaj insulin los ntawm ib lub khob, nws yog qhov tsim nyog los kuaj xyuas qhov xwm txheej ntawm nws cov ntsiab lus. Nyob rau hauv cov ntaub ntawm cov xyoob ntoo lossis cov tsos ntawm cov xim ntawm lub supernatant tom qab daws cov ntsiab lus ntawm lub vial, cov tshuaj no yuav tsum tsis txhob siv. Tam sim ntawd ua ntej txhaj tshuaj, lub vial ncua yog dov ntawm cov xib teg kom nws txoj kev ntsiag to thoob plaws hauv lub thauv yuav dhau los ua kev sib tsuam.
2. Cov tshuaj insulin yog sau los ntawm lub thau los ntawm kev hno nrog cov koob txhaj tshuaj tsis huv lub cork uas yav dhau los rub tawm nrog cawv lossis cawv tov ntawm iodine. Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov.
3. Yog tias tsuas siv ib hom tshuaj insulin, ces:
   • huab cua yog nqus mus rau hauv cov phwj tshuaj mus rau qhov muaj nuj nqi uas sib haum rau qhov xav tau ntawm cov tshuaj insulin, thiab tom qab ntawd cov pa tawm mus rau hauv lub vial,
   • cov koob txhaj nrog lub vial yog muab pauv kom lub khob yog thawb rov qab thiab qhov yuav tsum tau txhaj tshuaj ntawm cov tshuaj insulin,
   • lub koob tawm ntawm lub thawb tawm los. Cov koob txhaj tshuaj yuav tawm hauv huab cua thiab qhov tseeb ntawm cov koob tshuaj insulin raug kuaj.
4. Yog tias ob hom tshuaj insulin sib xyaw, tom qab ntawd tam sim ntawd ua ntej txhaj cov vial nrog kev ncua ntawm insulin (tov kua) yog dov ntawm cov xib teg kom nws txoj kev ntseeg siab thoob plaws hauv tag nrho cov ntim ntawm lub vial dhau los ua khaub ncaws. Ib lub ntim ntawm cov huab cua tau kos rau hauv cov koob txhaj uas yuav tsum sib haum nrog qhov xav tau ntawm kev ncua ntawm cov tshuaj insulin, thiab cov huab cua no tau nkag mus rau hauv lub vial nrog kev ncua ntawm cov kua dej. Tshem tawm rab koob tawm hauv lub raj mis. Ib zaug ntxiv, huab cua tau kos rau hauv lub koob txhaj tshuaj mus rau tus nqi ntawm qhov yuav tsum tau txhaj ntawm pob tshab cov kua dej. Nkag no huab cua rau hauv lub raj mis uas tov kua dej. Cov koob txhaj tshuaj nrog cov khob yog muab rov qab kom lub khob yog thaus ntiag tug thiab qhov hno tshuaj yuav tsum tau ntawm cov tshuaj insulin pob tshab tau sau. Tshem tawm cov cua ntawm lub koob txhaj tshuaj thiab tshawb xyuas qhov tseeb ntawm qhov koob tshuaj ntawm cov tshuaj insulin. Lub koob tau rov qab nkag rau hauv lub thauv nrog kev ncua ntawm kev tiv thaiv insulin thiab kev siv tshuaj yog sau. Tshem tawm cov cua ntawm lub koob txhaj tshuaj thiab xyuas qhov tseeb. Nws yog ib qho tsim nyog yuav tsum ntaus insulin hauv kab ua ntu zus. Qhov no saib xyuas cov teeb sib xyaw ntawm cov khoom sib xyaw hauv cov phwj. Sai li sai tau tom qab ua tiav ntawm cov haujlwm saum toj no, ib qho kev txhaj tshuaj.
5. Tuav daim tawv nqaij ntawm tus ntiv tes, hno rab koob rau hauv daim tawv nqaij ntawm ib kaum ntawm kwv yees li 45 ° thiab txhaj insulin s / c.
6. Lub koob raug tshem tawm thiab qhov chaw txhaj tshuaj yog nias me ntsis li ob peb feeb kom tiv thaiv tau qhov khiav ntawm insulin.
7. Xav kom hloov chaw txhaj tshuaj.

Kev phiv los ntawm cov tshuaj Pharmasulin

Tsis tshua muaj - lipodystrophy, insulin tsis kam, tshuaj tiv thaiv tsis haum. Nrog lub sijhawm ntev insulin kho ntawm qhov chaw txhaj tshuaj, ntu ntawm atrophy lossis hypertrophy ntawm subcutaneous rog txheej yuav pom. Cov tshwm sim no tuaj yeem tiv thaiv tau los ntawm qhov hloov tas mus li hloov qhov chaw txhaj tshuaj. Yog tias muaj qhov tsis haum ib ce rau lwm hom tshuaj insulin hauv tus neeg mob lub keeb kwm, cov tshuaj no tau raug tshuaj tom qab tau txais kev kuaj tsis pom qhov tsis zoo. Thaum muaj kev fab tshuaj, nws yog qhov yuav tsum hloov tus neeg mob mus rau lwm hom tshuaj insulin thiab muab tshuaj tiv thaiv kev ua xua rau nws. Nyob rau hauv kev tswj hwm kev noj tshuaj ntau dhau ib koob tshuaj insulin lossis hla zaub mov, nrog rau kev ua rau lub cev ntau dhau, ib qho tshuaj tiv thaiv hypoglycemic rau insulin kuj yuav tshwm sim. Kev mob ntshav qis uas tsis tswj tau tuaj yeem tsim kho nrog kev haus cawv los ntawm tus neeg mob ntshav qab zib. Yog tias kev nyeem ntawm cov piam thaj hauv cov ntshav tau khaws cia hauv cov qib siab heev, qhov mob ntawm ketoacidosis tshwm sim. Xws li cov kev mob nyhav heev tuaj yeem tsim kho yog tias tus neeg mob tau txais koob tshuaj qis dua qhov tsim nyog. Qhov no tuaj yeem yog los ntawm kev xav tau ntau ntxiv rau insulin thaum lub sijhawm mob, kev ua txhaum ntawm kev noj zaub mov, kev tswj kav tsis txaus ntawm insulin lossis koob tshuaj insulin tsis txaus. Kev txhim kho ntawm ketoacidosis tuaj yeem txheeb xyuas los ntawm kev soj ntsuam ntawm cov zis, nyob rau hauv uas muaj cov ntsiab lus siab ntawm cov piam thaj thiab ketone lub cev raug kuaj pom. Maj mam, feem ntau nyob rau hauv ob peb teev lossis hnub, cov tsos mob tshwm sim xws li nqhis dej, nce ntxiv diuresis, ploj tsis qab los, nkees, tawv nqaij qhuav, nqus thiab ua pa ceev. Yog hais tias ib tug neeg mob hauv tus mob no tsis tau kho, nws yog ib qho ua tau kom tus mob ntshav qab zib tsis hnov ​​qab nrog lub txiaj ntsig tuag.

Cov lus qhia tshwj xeeb rau kev siv cov tshuaj Farmasulin

Ntawm ib koob ntawm 4-8 IU, 1-2 zaug hauv ib hnub, cov tshuaj yuav siv tau los ua tus neeg sawv cev anabolic rau kev ua kom tiav ntawm lub cev, furunculosis, thyrotoxicosis, atony ntawm lub plab, mob siab ntev, thiab cov qauv mob thawj zaug. Hauv kev xyaum ua lub siab ntsws, nws yog qhov tsim tawm rau kev kho kom dav ntxiv. Siv rau kev kho mob ntshav qab zib tsis xeev, nyob rau hauv kev phais mob.

Kev sib cuam tshuam tshuaj yaj yeeb tshuaj

Glucagon, diazoxide, phenothiazine derivatives, thiazide diuretics, corticosteroids, cov thyroid hormones, qhov kev tiv thaiv tshuaj tiv thaiv hormonal ua rau lub cev tsis muaj zog tiv thaiv cov tshuaj insulin. Ib qho kev nce ntxiv ntawm qhov mob ntawm cov qog ntshav hypoglycemic ntawm lub cev yog qhov ua tau nrog kev tswj hwm ntawm salicylates, guanethidine, MAO inhibitors, oxytetracycline, thiab anabolic steroids. Cov tshuaj Insulin nce qhov ua rau mob ntsws mob ntawm PASK. Insulin thiab strophanthin muaj qhov sib thooj cuam tshuam rau ob qhov kev ua haujlwm tsis sib haum thiab myocardial metabolism, vim qhov kev sib txuam tsis muaj zog lossis cuam tshuam lawv cov teebmeem muaj peev xwm ua tau. Hauv kev kho mob nrog cov tshuaj insulin, kev saib xyuas ua ntej ntawm anaprilin tuaj yeem ua rau lub sijhawm ntshav nce siab tsawg. Cawv kuj tseem yuav ua rau muaj kev txo ntshav qab zib kom tsawg.

Kev noj tshuaj Pharmasulin overdose, cov tsos mob thiab kev kho mob

Nws yog meej thiab txheeb ze. Ua rau muaj cov ntshav qog ntshav ntau dhau. Kev noj zaub mov tsis txaus (tsis muaj zaub mov noj tom qab txhaj tshuaj insulin), ua si lub cev thiab haus dej cawv ntau ua rau nws tshwm sim. Tshwj xeeb feem ntau nws tuaj yeem tshwm sim nrog chav kawm labile ntawm tus kab mob, hauv cov neeg laus cov neeg mob, nrog lub raum tsis ua haujlwm. Clinically ua pov thawj los ntawm kev tawm hws, tshee tshee thiab lwm yam ntawm lub zog tshwj xeeb, tsis nco qab ceev ceev. Kev kho mob muaj nyob rau hauv lub sijhawm ua ntej cov piam thaj sab hauv (hauv thawj theem ntawm kev mob ntshav qab zib). Txhawm rau tiv thaiv kom tsis txhob mob hypoglycemia, tus neeg mob tau muab tshuaj yej qab zib lossis ob peb lub txiv qab zib. Yog tias tsim nyog, iv txhaj tshuaj ntawm 40% kua nplaum ntawm cov tshuaj qab zib yog ua haujlwm nrawm lossis 1 mg ntawm glucagon yog muab tshuaj intramuscularly. Yog hais tias tus neeg mob tsis rov qab los ntawm kev tsis nco qab tom qab ua kom cov ntshav qab zib hauv lub cev, nws yuav tsum tau tswj hwm mannitol lossis qib siab ntawm corticosteroids txhawm rau tiv thaiv kom tsis txhob mob hlwb.

Cia tej yam kev mob ntawm cov tshuaj Farmasulin

Nyob rau hauv qhov chaw tsaus ntawm qhov kub ntawm 2–8 ° С. Cov tshuaj insulin yuav tsum tsis txhob khov lossis raug rau tshav ntuj! Cov tshuaj insulin vial tuaj yeem khaws cia hauv chav tsev qhov kub (txog 25 ° C) rau 6 lub lis piam. Nyob rau hauv cov ntaub ntawm cov xyoob ntoo lossis cov tsos ntawm cov xim ntawm lub supernatant tom qab daws cov ntsiab lus ntawm lub vial, cov tshuaj no yuav tsum tsis txhob siv.

Lub Npe:

Farmasulin (Farmasulin)

1 ml ntawm Farmasulin N tshuaj muaj:
Tib neeg lub cev biosynthetic insulin (ua los ntawm DNA siv thev naus laus zis) - 100 IU,
Cov khoom xyaw ntxiv.

1 ml ntawm Pharmasulin H NP ncua kev kawm muaj:
Tib neeg lub cev biosynthetic insulin (ua los ntawm DNA siv thev naus laus zis) - 100 IU,
Cov khoom xyaw ntxiv.

1 ml ntawm kev ncua ntawm Farmasulin H 30/70 muaj:
Tib neeg lub cev biosynthetic insulin (ua los ntawm DNA siv thev naus laus zis) - 100 IU,
Cov khoom xyaw ntxiv.

Pharmacological kev txiav txim

Farmasulin yog cov tshuaj uas muaj cov nyhuv ntawm lub suab hypoglycemic. Farmasulin muaj cov tshuaj insulin, cov tshuaj uas tswj cov metabolism hauv qabzib. Ntxiv nrog rau kev tswj kev ua kom ntshav qabzib, insulin kuj tseem cuam tshuam ntau cov txheej txheem anabolic thiab anti-catabolic hauv cov ntaub so ntswg. Cov tshuaj Insulin txhim kho kev sib txuas ntawm glycogen, glycerol, cov protein thiab fatty acids nyob rau hauv cov leeg nqaij, thiab kuj tseem nce qhov kev nqus ntawm amino acids thiab txo cov glycogenolysis, ketogenesis, neoglucogenesis, lipolysis thiab catabolism ntawm cov protein thiab amino acids.
Farmasulin N yog qhov tshuaj insulin-ua yeeb yam sai. Muaj cov tib neeg insulin tau los ntawm kev siv cov DNA siv thev naus laus zis. Cov kev kho mob ntxim nyiam tau ceeb toom 30 feeb tom qab subcutaneous tswj hwm thiab kav ntev li 5-7 teev. Lub siab plasma ntshav nce mus txog hauv 1-3 teev tom qab txhaj tshuaj.

Thaum siv tshuaj yeeb Farmasulin H NP, lub siab ntshav plasma qhov tseem ceeb ntawm cov tshuaj nquag tshwm sim tom qab 2-8 teev. Kev kho mob nyhuv tau ntev li ntawm 60 feeb tom qab kev tswj hwm thiab kav ntev li 18-24 teev.
Thaum siv cov tshuaj Farmasulin N 30/70, kev kho mob tshwm sim tsis pub dhau 30-60 feeb thiab kav ntev li 14-15 teev, hauv qee cov neeg mob txog 24 teev. Lub plasma plasma qhov siab tshaj plaws ntawm cov nquag tiv thaiv tau pom zoo 1-8.5 teev tom qab kev tswj hwm.

Txoj kev ntawm daim ntawv thov

Farmasulin N:
Cov tshuaj yog npaj rau subcutaneous thiab leeg tswj hwm. Tsis tas li ntawd, txoj kev daws teeb meem tuaj yeem muab cov tshuaj intramuscularly, txawm hais tias subcutaneous thiab cov leeg tswj hwm yog qhov zoo dua. Cov koob tshuaj thiab lub sijhawm ntawm kev tswj hwm ntawm cov tshuaj Farmasulin N yog txiav txim los ntawm tus kws kho mob, ua raws li cov kev xav tau ntawm txhua tus neeg mob. Subcutaneously, cov tshuaj tau pom zoo kom ua rau lub xub pwg, ncej puab, pob tw lossis plab. Nyob hauv tib qho chaw, kev txhaj tshuaj raug pom zoo tsis pub ntau tshaj 1 zaug hauv ib hlis. Thaum txhaj tshuaj, zam kom tsis txhob muab cov tshuaj rau hauv cov leeg ntshav. Tsis txhob txhuam thaj chaw txhaj tshuaj.

Cov tshuaj tov hauv cov roj cartridges yog npaj rau kev siv nrog rab koob xaum xim “CE”. Nws raug tso cai tsuas yog siv cov ntshiab, tsis muaj xim uas tsis muaj cov pom pom. Yog tias nws yog qhov yuav tsum tau ua los ua ob peb txoj kev npaj tshuaj insulin, qhov no yuav tsum tau ua los ntawm siv cov phwj sib txawv. Hais txog tus txheej txheem ntawm kev them tus nqi cartridge, raws li txoj cai, cov ntaub ntawv tau muab rau hauv cov lus qhia rau daim ntawv xaum xim.

Nrog kev qhia txog cov tshuaj hauv vials, koob txhaj tshuaj yuav tsum tau siv, kev kawm tiav ntawm uas sib haum rau hom tshuaj insulin no. Nws raug nquahu tias cov koob txhaj tshuaj ntawm tib lub tuam txhab thiab hom siv los tswj cov tshuaj Pharmasulin N, vim tias kev siv lwm cov koob txhaj tshuaj yuav ua rau kom tsis raug tshuaj. Tsuas yog cov ntshiab, tsis muaj xim uas tsis muaj cov pom pom tau tso cai. Kev txhaj tshuaj yuav tsum tau ua nyob rau hauv cov teeb meem aseptic. Kev daws ntawm chav sov yog pom zoo. Txhawm rau txhawm rau qhov kev daws teeb meem rau hauv cov phwj, koj yuav tsum xub kos cov cua mus rau hauv lub hauv siab kom cov cim uas yuav tsum tau txhaj ntawm cov tshuaj insulin, ntxig lub koob tso rau hauv lub vial thiab los ntshav. Tom qab ntawd, lub raj mis tig mus rau sab hauv thiab qhov yuav tsum tau sau ntawm kev daws. Yog tias nws yog qhov tsim nyog los tswj cov tshuaj insulins sib txawv, nyias koob txhaj tshuaj thiab koob tau siv rau txhua qhov.

Farmasulin H NP thiab Farmasulin H 30/70:
Farmasulin N 30/70 - ib qho tsim nyog tov ntawm cov kev daws teeb meem Farmasulin N thiab Farmasulin H NP, uas tso cai rau koj nkag mus rau ntau yam insulins yam tsis tau siv tshuaj tua kab ntawm insulin.

Farmasulin H NP thiab Farmasulin H 30/70 raug muab tshuaj subcutaneously ua raws li cov cai aseptic. Kev txhaj tshuaj subcutaneous tau tsim rau hauv lub xub pwg, pob tw, ncej puab lossis hauv plab, txawm li cas los xij, nws yuav tsum tau yug los rau hauv lub siab tias nyob ntawm tib qhov chaw txhaj tshuaj yuav tsum tsis ua ntau tshaj 1 zaug hauv ib hlis. Zam kev sib cuag nrog cov tshuaj thaum txhaj tshuaj. Nws raug tso cai kom siv tsuas yog ib qho kev daws teeb meem uas tom qab tshee tsis muaj plaub ya ri lossis cov av hauv av ntawm lub ntsej muag ntawm lub thawb. Ua ntej kev tswj hwm, co lub raj mis hauv lub xib teg kom txog thaum ua kom muaj kev sib txig sib luag. Nws yog txwv tsis pub khaus lub raj mis, vim tias qhov no tuaj yeem ua rau tsim cov npuas dej thiab cov teeb meem nyuaj nrog kev teeb tsa cov koob tshuaj. Tsuas yog siv cov koob txhaj nrog ib qho kev kawm tiav tsim nyog rau cov koob tshuaj insulin. Lub sijhawm nruab nrab ntawm kev tswj hwm ntawm kev siv tshuaj thiab cov khoom noj yuav tsum tsis pub dhau 45-60 feeb rau cov tshuaj Farmasulin H NP thiab tsis pub dhau 30 feeb rau cov tshuaj Farmasulin H 30/70.

Thaum lub sij hawm siv cov tshuaj Farmasulin, kev noj zaub mov noj yuav tsum ua raws.
Txhawm rau txiav txim siab ntawm koob tshuaj, qib ntawm glycemia thiab glucosuria thaum nruab hnub thiab theem ntawm kev yoo glycemia yuav tsum raug coj los siv.
Txhawm rau txhawm rau muab ncua nyob rau hauv lub koob txhaj tshuaj, koj yuav tsum xub kos cov cua mus rau hauv lub koob txhaj rau qhov cim uas txiav txim siab qhov yuav tsum tau txhaj, tom qab ntawd ntxig lub koob tso rau hauv lub vial thiab los ntshav. Tom ntej, tig lub raj mis sab hauv thiab sau cov nqi tsim nyog ntawm kev ncua.

Pharmasulin yuav tsum tau tswj hwm los ntawm tuav daim tawv nqaij hauv cov quav ntawm cov ntiv tes thiab ntxig rau rab koob ntawm kaum ntawm 45 degrees. Txhawm rau tiv thaiv qhov khiav ntawm cov kua dej tom qab kev tswjhwm ntawm qhov raug ncua, qhov chaw txhaj tshuaj yuav tsum raug nias me ntsis. Nws yog txwv tsis pub txhuam qhov chaw txhaj tshuaj ntawm insulin.
Ib qho hloov pauv, suav nrog daim ntawv tso tawm, hom thiab hom tshuaj insulin, yuav tsum muaj kev saib xyuas ntawm tus kws kho mob.

Sab sij huam

Thaum lub sijhawm kho nrog Pharmasulin, qhov kev xav tsis pom zoo tshaj plaws yog hypoglycemia, uas tuaj yeem ua rau tsis nco qab thiab tuag. Feem ntau, hypoglycemia yog los ntawm kev noj zaub mov noj, muab cov tshuaj insulin ntau dhau los lossis haus dej siab dhau, nrog rau kev haus dej haus cawv. Txhawm rau zam kev txhim kho hypoglycemia, kev noj zaub mov noj kom pom zoo yuav tsum tau ua raws thiab cov tshuaj yuav tsum ua raws li nruj me ntsis raws li kws kho mob pom zoo.

Tsis tas li ntawd xwb, feem ntau nrog kev siv lub sijhawm ntev ntawm cov tshuaj Farmasulin, kev txhim kho ntawm cov tshuaj tiv thaiv insulin thiab atrophy lossis hypertrophy ntawm subcutaneous rog txheej ntawm qhov chaw txhaj tshuaj yog ua tau. Nws tseem ua tau rau kev txhim kho ntawm cov tshuaj tiv thaiv tsis haum lub cev, nrog rau cov kab mob hauv lub cev rau hauv txoj kev ntawm txoj hlab ntsha hypotension, bronchospasm, tawm hws ntau dhau thiab urticaria.
Nrog rau kev txhim kho yam tsis xav tau, koj yuav tsum sab laj nrog kws kho mob, vim tias qee qhov ntawm lawv yuav tsum tsis siv tshuaj ntxiv thiab kho tshwj xeeb.

Cov Yuav Tsum Muaj

Farmasulin tsis raug sau tseg rau cov neeg mob uas paub tias lub siab ntsws tsis ua hauj lwm zoo rau hauv cov tshuaj.
Farmasulin raug txwv rau kev siv nrog lub qog ntshav qab zib.
Cov neeg mob uas mob ntshav qab zib mus ntev, mob ntshav qab zib neuropathy, nrog rau cov neeg mob uas tau txais beta-blockers, yuav tsum siv cov tshuaj Pharmasulin nrog ceev faj, vim tias nyob rau hauv cov xwm txheej zoo li no cov tsos mob ntawm hypoglycemia yuav mob me lossis hloov.

Koj yuav tsum sab laj nrog koj tus kws kho mob txog kev siv tshuaj ntau ntxiv thaum muaj kev loj hlob ntawm adrenal, lub raum, qaij thiab lub qog ua rau lub caj pas tsis ua haujlwm, nrog rau cov mob tsis meej, xws li qhov no, kev kho tshuaj insulin yuav tsum tau ua.
Hauv kev xyaum ua menyuam yaus, rau kev noj qab haus huv, nws raug tso cai siv cov tshuaj Pharmasulin txij thaum yug los.
Ceev faj yuav tsum tau siv thaum tsav tsheb uas yuav ua rau lub tshuab tsis zoo thiab tsav lub tsheb thaum lub sij hawm kho nrog Pharmasulin.

Cev xeeb tub

Farmasulin tuaj yeem siv rau hauv cov poj niam cev xeeb tub, txawm li cas los xij, nws yuav tsum tau yug hauv siab tias thaum cev xeeb tub, yuav tsum tau them nyiaj tshwj xeeb rau kev xaiv ntawm koob tshuaj insulin, txij li lub sijhawm no xav tau cov tshuaj insulin tuaj yeem hloov pauv. Nws raug nquahu kom koj sab laj nrog koj tus kws kho mob yog tias koj cev xeeb tub lossis npaj muaj menyuam. Cov piam thaj hauv ntshav thaum cev xeeb tub yuav tsum tau saib xyuas kom zoo.

Yeeb tshuaj sib cuam tshuam

Qhov ua tau zoo ntawm cov tshuaj Farmasulin tuaj yeem txo qis thaum ua ke nrog kev tiv thaiv qhov ncauj, cov tshuaj thyroid, glucocorticosteroids, beta2-adrenergic agonists, heparin, lithium npaj, diuretics, hydantoin, thiab tshuaj antiepileptic.

Muaj ib qho kev txo qis hauv kev xav tau insulin nrog kev siv tshuaj yaj yeeb Pharmasulin nrog cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, salicylates, monoamine oxidase inhibitors, sulfonamide inhibitors, angiotensin-hloov mus rau enzyme inhibitors, beta-adrenergic receptor blockers, ethyl cawv, octreotide, tetraflamide, tetrafiloferfam, tetrafiloferfam, tetrafiloferfam, tetrafiloferfam, tetrafiloferfam, tetrafiloferfam thiab phenylbutazone.

Kev sib cuam tshuam nrog lwm yam tshuaj thiab lwm yam kev sib cuam tshuam

Qee cov tshuaj ua rau cov metabolism hauv qabzib. Tus kws kho mob yuav tsum raug qhia paub txog txhua yam kev kho mob uas tau tso nrog kev siv cov tshuaj insulin.

Yog tias koj xav siv lwm cov tshuaj, koj yuav tsum sab laj nrog koj tus kws kho mob.

Qhov xav tau rau cov tshuaj insulin tuaj yeem nce ntxiv nrog kev siv tshuaj nrog cov kev ua si hyperglycemic, xws li tshuaj tiv thaiv qhov ncauj, glucocorticoids, cov thyroid hormones thiab kev loj hlob hormone, danazole, β ₂ sympathomimetics (xws li ritodrin, salbutamol, terbutaline), thiazides.

Kev xav tau cov tshuaj insulin tuaj yeem txo qis nrog kev siv cov tshuaj nrog hypoglycemic kev ua si, xws li tshuaj tiv thaiv hypoglycemic qhov ncauj, salicylates (piv txwv li acetylsalicylic acid), sulfaantibiotics, qee cov tshuaj tiv thaiv kab mob (MAO inhibitors), qee cov tshuaj angiotensin-inhibiting enzyme inhibitors (blockptenaprilpropyl, Captaprilopilil, Captaprilopilil, Captaprilopilil) tsis xaiv hom tshuaj tiv thaiv or-blockers lossis dej cawv.

Somatostatin analogues (octreotide, lanreotide) tuaj yeem txhim kho thiab ua rau cov qaug zog tsis txaus siab rau kev xav tau.

Daim ntawv thov nta

Txhua yam hloov pauv ntawm hom lossis hom tshuaj insulin yuav tsum tau ua nyob rau hauv kev saib xyuas mob nkeeg nruj me ntsis. Hloov hauv kev ua kom pom tseeb, hom (cov chaw tsim khoom), hom (ceev, nruab nrab, ua haujlwm ntev), hom (tsiaj insulin, tib neeg insulin, ib qho sib piv ntawm tib neeg insulin) thiab / lossis cov txheej txheem ntawm kev npaj (insulin tau siv siv DNA thev naus laus zis, rau hauv Tsis zoo li tsiaj insulin) yuav tsum tau hloov tshuaj ntau npaum li cas.

Cov koob tshuaj siv hauv kev kho mob ntawm cov neeg mob nrog tib neeg cov tshuaj insulin tuaj yeem sib txawv ntawm cov koob tshuaj uas siv hauv kev kho mob ntawm insulin ntawm tsiaj keeb kwm. Yog tias xav tau los ntawm kev hloov kho koob tshuaj, kev hloov kho zoo li no tuaj yeem ua los ntawm thawj koob tshuaj lossis nyob hauv thawj ob peb lub lis piam lossis hli.

Hauv qee cov neeg mob uas muaj qhov tsis txaus siab tom qab hloov lawv los ntawm kev tswj hwm ntawm insulin ntawm tsiaj keeb kwm rau kev tswj hwm ntawm tib neeg cov tshuaj insulin, cov tsos mob thaum ntxov ntawm hypoglycemia tsis tau hais tawm lossis txawv ntawm cov tsos mob uas tau pom yav tas los hauv cov neeg mob no thaum kho cov tsiaj insulin. Hauv cov neeg mob uas muaj kev txhim kho tseem ceeb hauv cov piam thaj hauv ntshav (piv txwv, vim tias muaj kev kho mob los ntawm cov tshuaj insulin ntau dua), qee yam lossis tsis muaj cov tsos mob tshwm sim thaum ntxov ntawm tus mob ntshav qab zib tsis tuaj yeem pom nyob rau yav tom ntej, uas lawv yuav tsum paub txog. Cov tsos mob thaum ntxov ntawm hypoglycemia kuj tseem yuav muaj qhov sib txawv los yog tsawg tshaj tawm hauv cov neeg mob uas muaj cov mob ntshav qab zib ntev thiab mob ntshav qab zib neuropathy, lossis hauv cov neeg mob noj lwm yam tshuaj, xws li β-blockers, hauv kev sib txuam nrog kev kho mob siv.

Kev muaj ntshav lossis ntshav qab zib heev uas tsis raug kho dua tuaj yeem ua rau tsis nco qab, tsis nco qab, lossis tas sim neej.

Kev noj tshuaj tsis haum lossis ncua kev kho mob (tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib insulin-tiv thaiv ntshav qab zib) tuaj yeem ua rau hyperglycemia thiab muaj feem ua rau tuag taus ntshav qab zib ketoacidosis.

Cov tshuaj tua kab mob tuaj yeem tsim cov tshuaj tua kab mob los kho tib neeg, txawm li cas los xij ntawm qis dua li nrog cov tsiaj cov tsiaj ua kom huv.

Qhov xav tau rau insulin hloov pauv ntau nrog kev ua haujlwm ntawm adrenal ua haujlwm, pituitary caj pas, cov thyroid caj pas, lub raum lossis lub siab ua haujlwm.

Qhov kev xav tau rau insulin kuj tseem tuaj yeem nce ntxiv thaum muaj mob los yog qaug zog ntawm kev ntxhov siab ntxhov siab.

Qhov xav tau hloov qhov koob tshuaj yuav tshwm sim thaum muaj kev hloov pauv ntawm kev siv dag zog lossis kev noj lub cev ib txwm muaj.

Ua ke siv nrog pioglitazone

Cov neeg muaj mob plawv tsis txaus siab tau tshaj tawm nrog kev siv pioglitazone nrog cov insulin, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj feem ua rau muaj mob plawv tsis ua hauj lwm.

Siv thaum cev xeeb tub lossis lactation.

Tswj cov qib hauv qabzib nyob hauv ntshav ntawm cov poj niam cev xeeb tub yog qhov tseem ceeb yog tias lawv raug kho nrog insulin (nrog insulin-tiv thaiv thiab kev tiv thaiv kev mob ntshav qab zib). Qhov xav tau rau cov tshuaj insulin feem ntau poob qis thaum thawj peb lub hlis ntawm cev xeeb tub, tom qab ntawd nws nce ntxiv thaum lub caij thib ob thiab thib peb lub hlis. Cov poj niam muaj ntshav qab zib yuav tsum qhia rau lawv cov kws kho mob txog kev xeeb tub lossis lawv lub hom phiaj ua kom cev xeeb tub.

Kev soj ntsuam nruj ntawm cov ntshav qab zib thiab kev noj qab haus huv tseem ceeb heev rau cov poj niam cev xeeb tub uas muaj ntshav qab zib.

Hauv cov poj niam uas muaj ntshav qab zib, thaum pub niam mis, yuav muaj kev tswj hwm cov tshuaj insulin thiab / lossis noj zaub mov.

Lub peev xwm los cuam tshuam cov tshuaj tiv thaiv tus nqi thaum tsav tsheb lossis lwm yam txheej txheem.

Kev mob ntshav qab zib tuaj yeem cuam tshuam qhov tsis zoo ntawm kev saib xyuas thiab rov tshwm sim, uas yog, nws yog qhov phom sij hauv cov xwm txheej uas yuav tsum tau hais txog cov kev ua tau zoo, piv txwv li, thaum tsav tsheb lossis kev siv tshuab.

Cov neeg mob yuav tsum tau qhia paub meej txog qhov twg yuav tsum tau ceev faj ua ntej tsav tsheb kom tsis txhob ua kom tsis txhob mob ntshav qab zib, tshwj xeeb yog tias cov kev qhia ntxov ntawm hypoglycemia tsis tuaj lossis tsis meej, lossis yog tias exacerbations ntawm hypoglycemia tshwm sim tas li. Thaum zoo li no, tsis txhob tsav tsheb.

Kev phiv tshuaj

Kev mob ntshav qab zib yog ib qho kev phiv los sis siv tshuaj insulin rau cov neeg mob ntshav qab zib. Kev mob ntshav khov ntau heev tuaj yeem ua rau tsis nco qab, qee qhov xwm txheej hnyav - ua kom tuag. Cov ntaub ntawv ntawm cov zaus ntawm hypoglycemia tsis tau muab, vim tias hypoglycemia cuam tshuam nrog kev txhaj tshuaj ntawm cov tshuaj insulin thiab nrog lwm yam, xws li tus neeg mob noj zaub mov thiab qib ua si.

Kev tshwm sim hauv zos ntawm kev ua xua tuaj yeem pom los ntawm qhov hloov ntawm qhov chaw txhaj tshuaj, liab ntawm daim tawv nqaij, o, khaus. Lawv feem ntau nyob ntawm ob peb hnub mus rau ntau lub lis piam. Qee qhov xwm txheej, nws cuam tshuam nrog cov kua dej tsis txaus, tab sis nrog rau lwm yam, piv txwv li, kev tsis haum xeeb nyob rau hauv qhov muaj pes tsawg leeg ntawm daim tawv nqaij ntxuav los yog tsis muaj kev paub nrog kev txhaj tshuaj.

Kev tsis haum tshuaj rau lub cev yog ib qho muaj feem tshwm sim heev thiab yog ib qho qauv qhia kev tsis haum rau cov tshuaj insulin, suav nrog ua pob rau tag nrho lub cev, ua pa ceev, hawb pob, ntshav qis, ntshav nce siab, thiab tawm hws. Cov teeb meem loj ntawm kev tsis haum tshuaj lom neeg yuav ua rau muaj sia. Qee qhov tshwj xeeb ntawm kev tsis haum tshuaj loj rau Farmasulin ® N NP, tsim nyog ntsuas yuav tsum ua tam sim ntawd. Nws yuav tsim nyog los hloov cov tshuaj insulin los yog kho txoj kev kho kom zoo.

Ua ntej, lipodystrophy tuaj yeem tshwm sim ntawm qhov chaw txhaj tshuaj.

Cov kab mob ntawm edema tau tshaj tawm nrog kev siv tshuaj insulin, tshwj xeeb hauv cov neeg muaj kev txo qis metabolism, nws tau txhim kho los ntawm kev siv tshuaj insulin ntau dua.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

FARMASULIN® H NP

xyov. d / nyob rau hauv. 100 IU / ml fl. 10 ml, No. 1
xyov. d / nyob rau hauv. 100 IU / ml cartridge 3 ml, No. 5

Tib Neeg Insulin 100 IU / ml
Lwm cov khoom xyaw: distilled m-cresol, glycerol, phenol, protamine sulfate, zinc oxide, sodium phosphate dibasic, hydrochloric acid 10% tov lossis sodium hydroxide 10% kev daws (txog pH 6.9-7.5), dej kev txhaj tshuaj.
1 ml ntawm Farmasulin N NP muaj 100 IU ntawm tib neeg biosynthetic insulin ua siv DNA thev naus laus zis thev naus laus zis.

FARMASULIN® H 30/70

xyov. d / nyob rau hauv. 100 IU / ml fl. 10 ml, No. 1
xyov. d / nyob rau hauv. 100 IU / ml cartridge 3 ml, No. 5

Tib Neeg Insulin 100 IU / ml
Lwm cov khoom xyaw: distilled m-cresol, glycerol, phenol, protamine sulfate, zinc oxide, sodium phosphate dibasic, hydrochloric acid 10% tov lossis sodium hydroxide 10% kev daws (txog pH 6.9-7.5), dej kev txhaj tshuaj.
1 ml ntawm Farmasulin H 30/70 muaj 100 IU ntawm tib neeg biosynthetic insulin ua siv DNA thev naus laus zis thev naus laus zis.

Cov Tshuaj Pharmacokinetics

Yawg Hlas N - Kev ua haujlwm sai insulin, yog kev npaj ntawm tib neeg cov insulin tau los ntawm kev siv DNA thev naus laus zis.
Lub chaw muag tshuaj ntawm cov tshuaj insulin tsis cuam tshuam txog cov kev ua hauv lub cev ntawm qhov kev paub mob.
Qhov pib ntawm cov nyhuv yog 30 feeb tom qab subcutaneous tswj hwm. Qhov siab tshaj qhov siab tshaj plaws tau pom ntawm 1 thiab 3 teev tom qab txhaj tshuaj. Lub sijhawm ntawm kev tswj cov tshuaj kho tau yog los ntawm 5 txog 7 teev. Kev ua haujlwm ntawm insulin nws txawv nyob ntawm seb nws qhov koob npaum li cas, qhov chaw txhaj tshuaj, qhov kub thiab txias thiab qhov kev tawm dag zog ntawm tus neeg mob.
Thaum lub sij hawm cov kev tshawb fawb tshuaj lom, tsis muaj qhov tshwm sim loj heev uas cuam tshuam nrog kev siv tshuaj yeeb tshuaj tau pom.