Ntsiav tshuaj Thrombo ACC Indices

Daim ntawv qhia cov tshuaj tso tawm ntawm Thrombopol yog enteric-coated ntsiav tshuaj: liab dawb, biconvex, puag ncig (hauv cov hlwv ntawm 10 pcs., Hauv daim ntawv cov duab los ntawm 3, 5 lossis 6 blisters, hauv lub hlwv ntawm 25 pcs., Hauv daim ntawv ntim ntawm 2 blisters).

Composition 1 ntsiav tshuaj:

• cov tshuaj nquag: acetylsalicylic acid - 75 lossis 150 mg,
• Cov khoom xyaw pabcuam: pob kws hmoov txhuv nplej siab, sodium carboxymethyl hmoov txhuv nplej siab, microcrystalline cellulose,
• lub plhaub: hypromellose, Acrylic Yog sib xyaw rau txheej ntsiav tshuaj, muaj pes tsawg leeg yog sodium lauryl sulfate, sodium hydrogen carbonate, methacrylic acid copolymer (hom C), talc, triethyl citrate, titanium dioxide, colloidal silicon dioxide, crimson zas xim (Ponceau 4R).

Cov Tshuaj Hauv Tshuaj

Thrombopol yog ib qho ntawm NSAIDs (tshuaj siv tsis-tshuaj steroidal), tshuaj tua kab mob antiplatelet.

Lub hauv paus ntawm cov txheej txheem ntawm kev ua ntawm acetylsalicylic acid yog qhov tsis paub kev xav ntawm COX-1 (cyclooxygenase), uas ua rau muaj kev cuam tshuam hauv kev hais txog ntawm thromboxane A₂ thiab kev tsuj ntawm cov platelet aggregation.

Cov nyhuv antiplatelet tshwm sim txawm tias tom qab siv cov koob tshuaj me me, lub sijhawm ntev ntawm nws cov nyhuv tom qab siv ib zaug yog 7 hnub. Acetylsalicylic acid tuaj yeem siv los kho thiab tiv thaiv cov kab mob / kab mob li nram no: myocardial infarction, mob hnyav ntawm varicose leeg, mob plawv.

Tsis tas li ntawd, cov khoom muaj cov tshuaj analgesic, anti-inflammatory thiab antipyretic.

Vim tias cov kuab tshuaj nkag mus hauv cov ntsiav tshuaj, acetylsalicylic acid raug tso tawm hauv ib puag ncig alkaline ntau ntawm duodenum, uas yuav pab txo nws qhov kev tsis haum xeeb ntawm lub plab hnyuv.

Cov Tshuaj Pharmacokinetics

Qhov nqus ntawm acetylsalicylic acid los ntawm Thrombopol pib 3-4 teev tom qab noj tshuaj (qhov no lees tias muaj kev cuam tshuam zoo ntawm kev tshem tawm cov ntsiav tshuaj hauv plab). C_max (qhov siab tshaj plaws ntawm ib yam khoom) hauv ntshav nruab nrab 6.72 thiab 12.7 μg / ml (rau cov ntsiav tshuaj ntawm 75 thiab 150 mg, feem), lub sijhawm ncav nws yog kwv yees li 2-3 teev. Qhov nqus ntawm cov tshuaj no maj mam nqes mus rau hauv cov khoom noj hauv lub plab zom mov.

AUC (thaj tsam nyob rau hauv qhov kev txiav txim siab-lub sijhawm nkhaus) yog 56.42 thiab 108.08 μg × h / ml (rau cov ntsiav tshuaj ntawm 75 thiab 150 mg, feem).

Acetylsalicylic acid lom zem ntau thiab sai sai nkag mus rau hauv lub cev dej thiab cov ntaub so ntswg feem ntau. Qhov ntsuas ntawm nws txoj kev khi rau cov ntshav plasma protein yog txiav txim siab los ntawm kev ua siab ntev.

Kev faib tawm ntawm cov txheeb ze yog kwv yees li 0.15–0.2 l / kg; nws nce tib lub sij hawm nrog qhov nce ntawm cov ntshav ntawm thrombopol hauv cov ntshav.

Tsis zoo li lwm yam salicylates, tawm tsam keeb kwm ntawm kev rov ua dua ntawm cov tshuaj, cov tshuaj tsis muaj acetylsalicylic acid tsis tuaj yeem tshwm sim hauv cov ntshav cov ntshav.

Qee cov acetylsalicylic acid yog metabolized thaum nqus. Tus txheej txheem no tshwm sim nyob rau hauv kev cuam tshuam ntawm enzymes tsuas yog ua rau lub siab. Cov pa tshuaj hauv qab no tau tsim (pom nyob rau hauv cov zis thiab ntau cov ntaub so ntswg): phenyl salicylate, glucuronide salicylate, thiab salicyluric acid.

T_1/2 (ib nrab-lub neej) ntawm acetylsalicylic acid los ntawm ntshav ntshav yog nyob rau hauv thaj tsam li 15 mus rau 20 feeb.

Tsuas yog 1% ntawm qhov ncauj qhov ncauj tawm hauv cov qauv uas tsis muaj kua qaub acetylsalicylic acid los ntawm ob lub raum, qhov seem yog salicylates thiab lawv cov metabolites.

Thaum tsis tuaj yeem ua rau lub raum tsis ua haujlwm, 80-100% ntawm ib koob tshuaj tsuas yog tawm los ntawm lub raum ua ntej 24-7 teev.

Txheej txheem metabolic hauv cov poj niam qeeb qeeb (vim tias qhov qis dua ntawm cov enzymes hauv cov ntshav cov ntshav).

Hauv cov neeg mob uas lub raum tsis ua haujlwm, zoo li hauv cov poj niam cev xeeb tub thiab cov menyuam yug tshiab, salicylates tuaj yeem tshem cov bilirubin los ntawm lub koom haum nrog albumin, uas ua rau pom kev bilirubin encephalopathy.

Kev ntsuas rau siv

• lub siab tsis ruaj ntseg,
• mob myocardial infarction (tiv thaiv cov thawj myocardial infarction nyob rau hauv qhov muaj kev pheej hmoo yam mob, tshwj xeeb yog mob ntshav qab zib mellitus, hyperlipidemia, ntshav tawm ntshav, rog dhau, haus luam yeeb, hauv hnub nyoog laus, nrog rau kev tiv thaiv ntawm myocardial infarction),
• mob stroke (tiv thaiv, suav nrog cov neeg mob qog ua ntu zus),
• transient cerebrovascular kev sib tsoo (tiv thaiv),
• thromboembolism (kev tiv thaiv nyob rau hauv lub sijhawm postoperative thiab tom qab kev tiv thaiv tsis zoo ntawm cov hlab ntsha, tshwj xeeb, mob hlab ntsha o hla kev sib tsoo, carotid artery endarterectomy, carotid artery angioplasty, arteriovenous shunting),
• txoj hlab ntsws txoj hlab ntsws loj thiab txoj hlab ntsws ntawm txoj hlab ntsws thiab nws cov ceg (tiv thaiv, suav nrog cov neeg mob tom qab kev phais mob ntau ntxiv nyob rau lub sijhawm ntev ntawm immobilization).

Cov Yuav Tsum Muaj

• exacerbation ntawm erosive thiab ulcerative txhab ntawm lub gastrointestinal ib ntsuj av,
• kev sib xyaw ua ke ntawm bronchial hawb pob, ua mob polyposis ntawm qhov mob hlab pas / qhov ntswg thiab tsis haum rau acetylsalicylic acid,
• hemorrhagic diathesis,
• mob hnyuv los ntshav,
• siv tib txhij nrog methotrexate ntawm koob tshuaj 15 mg ib lis piam los yog ntau dua,
• bronchial hawb pob los ntawm salicylates thiab NSAIDs,
• Kuv thiab III txiav tawm cev xeeb tub, nrog rau lub sijhawm pub mis,
• hnub nyoog txog 18 xyoo
• tsis pub ib tus neeg twg nkag rau ib qho twg ntawm cov tshuaj, nrog rau lwm cov NSAIDs.

Tus Txheeb Ze (Thrombopol raug kho raws li kev saib xyuas mob):

• polyposis ntawm lub qhov ntswg,
• mob gout
• kab mob ua pa nyuaj,
• hyperuricemia
• raum / nplooj siab tsis ua haujlwm,
• keeb kwm mob rwj thiab duodenal mob rwj los sis plab hnyuv los ntshav,
• bronchial hawb pob,
• quav nyab ua npaws
• kev tsis haum tshuaj
• ib txhij siv nrog anticoagulants,
• ib txhij siv nrog methotrexate hauv ib koob tshuaj kom txog li 15 mg ib lis piam twg,
• Lub hlis thib ob ntawm cev xeeb tub.

Sab sij huam

• lub plab zom mov: nce kev ua haujlwm ntawm daim siab enzymes, xeev siab, ntuav, raws plab, kub siab, mob hauv plab, mob rau ntawm lub plab mos ntawm lub plab thiab duodenum, suav nrog perforated, plab hnyuv los ntshav,
• cov hlab ntsha hauv nruab nrab: tinnitus, kiv taub hau,
• cov kab mob ua pa: bronchospasm,
• kev ua xua: Quincke's edema, urticaria,
• hematopoietic system: muaj kev los ntshav ntau, tsis tshua muaj ntshav liab.

Noj ntau dhau

Thawj cov tsos mob ntawm kev siv ntau dhau yog tshwm sim los ntawm kev ua kom xeev siab, ntuav, tinnitus thiab ua pa sai, ntxiv rau, cov kev mob tshwm sim hauv qab no yuav tshwm sim: tsis pom kev, hnov ​​lus, mob lub siab, mob taub hau, tsaug zog, hyperthermia, ua kom ntuav. Nrog rau kev qaug cawv hnyav, muaj kev cuam tshuam nyob rau hauv cov dej-electrolyte thiab acid-base tshuav (lub cev qhuav dej thiab cov metabolic acidosis) yuav tshwm sim.

Cov tsos mob ntawm tus mob me / mob nyhav ua rau muaj tshwm sim tom qab siv 150-300 mg / kg acetylsalicylic acid. Kev haus ntau dhau yog nrog koob tshuaj 300-500 mg / kg. Cov koob tshuaj ntau tshaj 500 mg / kg yog cov muaj peev xwm ua rau tuag tau.

Tsis muaj ib qho tshuaj tua tshwj xeeb rau thrombopol. Raws li kev kho mob, txhawm rau txo qis ntawm qhov tshuaj, cov kev coj ua hauv qab no yog taw qhia: ntxias kom ntuav thiab yaug lub plab. Cov kev ntsuas no pib siv tau 3-4 teev tom qab siv tshuaj, nyob rau hauv kev noj ntau dhau, lub sijhawm no ncua ntev txog 10 teev. Txhawm rau kom txo qhov nqus ntawm cov tshuaj, nws yog qhov yuav tsum tau ua qhov kev tshem tawm aqueous ntawm cov pa roj carbon ntau (cov neeg laus - 50-100 g, menyuam - 30-60 g), thaum saib xyuas cov dej-electrolyte tshuav yuav tsum tau tsim (yog tias tsim nyog, nws yuav tsum rov ua dua tshiab nyob rau lub sijhawm).

Hauv kev kho mob ntawm acidosis thiab txhawm rau txhawm rau tshaj tawm ntawm acetylsalicylic acid los ntawm ob lub raum, kev tswj hwm kev ua haujlwm ntawm sodium bicarbonate yog qhia, pH yuav tsum tau tswj nyob rau hauv thaj tsam ntawm 7-7.5.

Yog tias muaj mob hnyav, mob rau cov ntshav lossis mob peritoneal lim ntshav.

Vim tias kev nyiam ua pa ntawm tus mob ua pa acidosis, noj tshuaj uas tiv thaiv lub hauv nruab nrab lub paj hlwb (xws li barbiturates) yog txwv tsis pub. Nyob rau ntawm qhov muaj pa ntawm kev ua pa, nws yog ib qho tsim nyog yuav tsum ua kom paub meej txog kev ua pa thiab kev ua pa. Yog tias tsim nyog, ua lub teeb tsa hluav taws xob thiab muab qhov cua tshuab tawm.

Cov lus qhia tshwj xeeb

Acetylsalicylic acid tuaj yeem ua rau bronchospasm, zoo li ua rau mob hawb pob thiab lwm yam tshuaj tiv thaiv tsis haum. Cov kev pheej hmoo tseem ceeb yog keeb kwm ntawm kev ua mob ntsws asthma, ua npaws kub taub hau, mob ntsws qhov ntswg, mob ua pa ntev, ua xua rau lwm cov tshuaj (piv txwv li kev hloov ntawm daim tawv nqaij, khaus khaus, ua xua).

Kev siv cov tshuaj acetylsalicylic acid tuaj yeem ua rau sib txawv ntawm cov ntshav los ntshav thaum lub sijhawm / tom qab phais mob tas. Hauv qhov no, 5-7 hnub ua ntej txoj haujlwm xav tau, kev kho yuav tsum tsis ua mus ntxiv.

Txoj kev pheej hmoo ntawm los ntshav nce ntxiv nrog kev siv sib xyaw ntawm thrombopol nrog cov tshuaj anticoagulants, platelet aggregation inhibitors, thiab cov tshuaj thrombolytic.

Kev siv tshuaj ntau kawg ntawm acetylsalicylic acid nyob rau hauv rooj plaub ntawm kev xav ua ntej (tsis tshua tso zis uric acid) tuaj yeem ua rau mob gout.

Nrog kev sib xyaw ntawm thrombopol nrog methotrexate, qhov tshwm sim ntawm kev phiv tshuaj los ntawm hematopoietic plab hnyuv nce ntxiv.

Kev noj tshuaj ntau kawg ntawm cov tshuaj acetylsalicylic acid ua rau cov ntshav qab zib hauv lub cev, uas yuav tsum tau suav rau cov neeg mob ntshav qab zib uas tau txais tshuaj nrog cov nyhuv hypoglycemic.

Nrog kev siv ua ke ntawm glucocorticosteroids nrog thrombopol, ib qho kev txo qis hauv nws cov concentration hauv cov ntshav tau pom, thiab tom qab kev tshem tawm ntawm glucocorticosteroids, kev noj ntau dhau ntawm salicylates yog ua tau.

Tsis pom zoo siv nrog ibuprofen tsis pom zoo, vim tias nws txo qis kev ua haujlwm ntawm acetylsalicylic acid.

Kev sib xyaw ua ke ntawm acetylsalicylic acid thiab ethanol tsub kom muaj kev puas tsuaj rau lub qog ua pa ntawm txoj hnyuv thiab lub sijhawm ntev los ntshav.

Kev noj tshuaj ntau dhau yog qhov tshwj xeeb tshaj yog rau cov neeg laus. Vim tias qhov tseeb hais tias nyob rau hauv cov neeg mob uas muaj hnub nyoog 65 xyoos, qhov txo qis hauv lub raum txoj haujlwm yog qhov ua tau, pawg neeg mob no yuav tsum muab cov tshuaj thrombopol rau hauv cov koob tshuaj uas txo qis.

Cev xeeb tub thiab lactation

• Kuv thiab III trimesters ntawm cev xeeb tub: cov tshuaj yog contraindicated, kev siv ntawm Thrombopol nyob rau hauv kuv lub cev coj mus rau qhov sib cais ntawm lub sab saum toj palate thiab lub plawv tsis xws luag, nyob rau hauv lub sijhawm thib III - rau kev txwv tsis pub ua haujlwm, ua ntej lub sijhawm ntawm ductus arteriosus hauv tus menyuam, nce ntshav hauv niam / menyuam hauv plab, kev teem caij salicylates tam sim ntawd ua ntej kev yug menyuam tuaj yeem ua rau mob ntshav rau sab hauv, tshwj xeeb tshaj yog cov menyuam yaus ua ntej,
• II lub sijhawm cev xeeb tub: Thrombopol tsuas yog siv tau tom qab kev soj ntsuam zoo ntawm cov txiaj ntsig / kev pheej hmoo sib piv,
• lactation: cov tshuaj yog contraindicated.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj, cov nyhuv ntawm uas txhim kho thaum ua ke nrog thrombopol:

• methotrexate: cuam tshuam nrog kev poob qis hauv lub raum kev ntshiab thiab nws hloov chaw los ntawm kev sib txuas lus nrog cov protein, kev sib xyaw yog contraindicated lossis yuav tsum ceev faj (thaum siv nyob rau hauv cov koob tshuaj saum toj no lossis siab txog 15 mg ib lis piam, feem).
• heparin thiab kov yeej kev tawm tsam: cuam tshuam nrog lub cev tsis zoo ntawm lub plab ua haujlwm thiab kev hloov chaw ntawm cov kabmob tsis ncaj los ntawm kev sib txuas lus nrog cov protein,
• cov tshuaj thrombolytic thiab platelet aggregation inhibitors (ticlopidine),
• Digoxin: txuam nrog kev txo qis hauv nws lub raum kev ua haujlwm,
• cov kab mob hypoglycemic (insulin thiab sulfonylurea derivatives): nws yog txuam nrog cov khoom hypoglycemic ntawm acetylsalicylic acid nws tus kheej hauv kev txhaj tshuaj siab thiab kev hloov chaw ntawm sulfonylurea derivatives los ntawm kev sib txuas nrog cov protein,
• valproic acid: vim kev hloov chaw ntawm nws txoj kev txuas nrog cov protein,
• NSAIDs
• sulfonamides (suav nrog co-trimoxazole),
• barbiturates
• lithium ntsev.

Cov tshuaj uas nws cov nyhuv poob qis nrog kev siv ua ke nrog thrombopol:

• sulfinpyrazone, probenecid, benzbromaron thiab lwm yam tshuaj tiv thaiv gout uas ua rau kom uric acid ntxiv: cuam tshuam nrog kev sib tw tubular tshem tawm ntawm uric acid,
• antihypertensive tus neeg sawv cev, suav nrog angiotensin hloov mus rau enzyme inhibitors,
• aldosterone antagonists (tshwj xeeb spironolactone),
• voj diuretics (tshwj xeeb hauv furosemide).

Lwm qhov kev cuam tshuam tau:

• cawv: ntxiv cov nyhuv,
• glucocorticosteroids rau kev siv tshuab: ua rau cov haujlwm ntawm thrombopol.

Cov lus qhia luv luv ntawm cov tshuaj

Thrombo ACC yog tsim los ua cov ntsiav tshuaj zoo li me me dawb uas tau lo nrog cov txheej ci ci uas yooj yim soluble hauv cov hnyuv. Lub txee lub neej ntawm cov tshuaj tsis pub ntau tshaj peb xyoos, koj yuav tsum khaws cov pob nrog nws kom deb ntawm kev tshav ntuj. Cov tshuaj muaj pes tsawg leeg:

• cov tshuaj nquag: acetylsalicylic acid, raws li nws cov concentration, ntsiav tshuaj yog 50 lossis 100 mg,
• ntu ntu.

Cov tshuaj yog muab nyob hauv cov khw muag tshuaj tsis muaj tshuaj kho. Txawm li cas los xij, nws yuav tsum tau siv kom zoo thiab siv koob tshuaj pom zoo. Kev noj tshuaj ntau dua yog qhov tsis nyiam tshwj xeeb rau cov neeg laus.

Cov nyhuv pharmacological ntawm cov tshuaj yog ua raws li cov yam ntxwv tseem ceeb ntawm cov khoom tseem ceeb - salicylic acid: qhov txo qis hauv cov txheej txheem hloov, txo qis hauv cua sov, thiab ua kom loog. Nws ether txo cov synthesis ntawm thromboxane A2 hauv platelets, yog li pab txhawm rau tiv thaiv kev tsim cov ntshav txhaws. Cov nyhuv manifests nws tus kheej tam sim ntawd tom qab siv Thrombo ACC thiab muaj nyob hauv 7 hnub tom qab noj ib ntsiav tshuaj.

Kev qhia rau kev sau tshuaj

Cov txiaj ntsig tau pom ntawm qhov kev nqis tes ntawm cov tshuaj tseem ceeb tau tso cai rau nws raug kho rau prophylaxis thiab kev kho mob (ob qho tib si monotherapy thiab hauv kev sib xyaw nrog lwm txoj kev) ntawm myocardial infarction, ischemia, thiab varicose leeg. Cov cim tseem ceeb uas Trombo ACC tau sau tseg:

• lub xub ntiag ntawm angina pectoris,
• thawj thiab theem nrab prophylaxis hauv txoj kev kho mob ua rau mob plawv los ntawm kev tshwm sim ntawm myocardial infarction, tshwj xeeb tshaj yog yog hais tias tus neeg mob tau kuaj mob ntshav qab zib mellitus, kev rog dhau, kev coj tsis zoo (nicotine thiab cawv ntxiv), muaj hnub nyoog tawv,

Kev siv Thrombo ACC hauv kev sib xyaw nrog lwm cov tshuaj yog tso cai tsuas yog tom qab kev sib tham nrog tus kws kho mob uas tuaj koom: cov ntsiav tshuaj txhim kho cov nyhuv ntawm ib feem tseem ceeb ntawm kev npaj kho mob (suav nrog cov tsom rau kev kho mob plawv), vim li no cov txiaj ntsig ntawm txoj kev kho mob no tuaj yeem tsis paub txog.

Cov lus qhia rau kev tswj hwm kom yog ntawm Thrombo ACC

Cov ntsiav tshuaj yuav tsum noj hnub los yog yav tsaus ntuj, ua ntej noj mov thiab ntxuav nrog kom muaj dej txaus. Thrombo yog tus kws kho mob raws li kev kawm, lub sijhawm uas yuav tsum txiav txim siab los ntawm kws kho mob raws li cov kabmob. Yog tias cov tshuaj pabcuam pab thiab tsis ua rau muaj kev mob tshwm sim, ces lub sijhawm ua haujlwm ntawm cov thawj coj tuaj yeem ntxiv.

Haus Trombo ACC ntawm lub plab khoob yog txwv tsis pub siv!

Kev noj tshuaj li ib txwm siv yog 50-100 mg rau ib hnub. Txhawb cov koob tshuaj (nce txog 200 mg) yog kho rau kev kho mob prophylactic ntawm txoj hlab ntshav siab thiab thromboembolism.

Kev siv ntau dhau ntawm cov tshuaj yog tsis tshua muaj siab, txij li thaum cov ntsiav tshuaj muaj qhov tsis tshua muaj siab ntawm cov tshuaj nquag.

Hauv cov tib neeg muaj hnub nyoog qib siab, kev siv tshuaj ntau dhau heev ntawm cov tshuaj tuaj yeem ua rau ntau tus mob tsis zoo:

• tsis nco qab thiab ua kom sib haum ntawm txav,
• xeev siab thiab ntuav,
• feem ntau tsis muaj zog
• lub plawv ntxhov thiab cuam tshuam ntshav siab,
• tsis hnov ​​mob lub raum thiab hepatic muaj nuj nqi.

Thaum pib theem ntawm kev siv ntau dhau, nws yog qhov txaus kom noj cov pa hluav taws, ntxuav lub plab thiab rov qab ua kom cov dej-electrolyte sib npaug nrog kev kho mob thiab / lossis tshuaj ntsuab. Thaum muaj mob hnyav, kev kho mob sai sai nrog diuresis, hemodialysis, lav lav ntawm lub plab thiab txoj hnyuv, kev kho rov qab los ntawm cov kua qaub-puag kev tshuav nyiaj thiab kev kho kho yog qhov tsim nyog.

Kev noj tshuaj ntxiv ntawm Thrombo ACC

Thrombo ACC muaj ntau ntawm cov qauv tshuaj tiv thaiv, yog li xaiv cov tshuaj zoo tshaj raws li nws cov yam ntxwv, chav kawm ntawm kev tswj hwm, ntau npaum li cas thiab kev txwv tsis tuaj yeem yuav tsis yooj yim.

Raws li kev ntsuas rau kev txais neeg kawm	Raws li cov khoom siv tam sim no	Los ntawm pawg kws tshuaj (cov tshuaj tiv thaiv kab mob)
1. Kev kho thiab kev tiv thaiv ntawm ischemia: acorta Actalipid acecardol vasocardine rog npluav rog, tsis meej pem, hypertrans thromboMAG, holletar Vaj Huam Sib Luag. 2. Kev kho thiab tiv thaiv mob stroke thiab ischemic tawm tsam: agrenox, glycine canon cardionate clopidogrel Marevan phenylin, 3. Kev kho mob tsis haum lub ntsws pectoris: arikstra, tshuaj aspirin cardio Clititax Coromax plogrel fraxiparin.	agrenox, cov aspikor tshuaj aspirin cardio Iralgesic cardiomagnyl sanovask thrombopol UPSA UPSA, tsitrapak.	aggregate agrenox, aducil tshuaj aspirin cardio acecardol ventavis Sylt ilomedin, Clititax clopidex clopidogrel persantine plethazole phiaj tiklo effient.

Thaum hloov Thrombo ACC nrog lwm cov tshuaj, koj yuav tsum sab laj nrog koj tus kws kho mob txog kev sib xyaw nrog lwm cov tshuaj.

Chaw tsim tshuaj paus, tso tawm daim ntawv, muaj pes tsawg leeg, noj ntau npaum li cas, lus piav qhia

Thrombo ACC yog tsim los ntawm lub tuam txhab Austrian pharmaceutical GL. Pharma GmbH, uas nws cov nroj tsuag nyob hauv lub nroog Pannach. Nyob rau hauv Russia, tus sawv cev ntawm Austrian cov kws muag tshuaj yog lub tuam txhab "Valeant", uas nyob ntawm qhov chaw nyob: 115162, Moscow, st. Shabolovka, lub tsev 31, lub tsev 5. Nws yog nyob ntawm qhov chaw nyob uas koj tuaj yeem xa tag nrho cov ntawv foob txog cov tshuaj.

Thrombo ACC muaj nyob hauv ib daim ntawv tsuas tshuaj ntau npaum - nws qhov ncauj ntsiav tshuajenteric txheej zaj duab xis txheej. Cov ntsiav tshuaj tau ntim rau hauv cov hlwv (konvalyutki) ua los ntawm aluminium thiab polyvinyl chloride, uas, nyeg, tau muab tso rau hauv cov thawv ntawv thawv nrog rau cov ntawv sau nrog cov lus qhia rau kev siv. Hauv cov thawv - 14 lossis 20 ntsiav tshuaj.

Thrombo ACC ntsiav tshuaj muaj acetylsalicylic acid yog cov tshuaj ua kom nquag plias, uas yog muaj npe hu ua Aspirin. Tab sis tsis zoo li cov tshuaj Aspirin qub nrog kev siv tshuaj antipyretic thiab analgesic, qhov muaj pes tsawg leeg ntawm Trombo ACC muaj cov acetylsalicylic acid nyob rau hauv ntau npaum li cas, uas muab nws nrog tshuaj me ntsis sib txawv, namely, cov nyhuv antiplatelet. Yog li, hauv ntsiav tshuaj ntawm Thrombo ACC, acetylsalicylic acid muaj nyob hauv ob qhov tshuaj - 50 mg lossis 100 mg. Ob qhov tshuaj yog tsawg, thiab yog li ntawd cov tshuaj yuav siv tsuas yog rau, raws li cov tib neeg hais, "ntshav thinning", thiab tsis yog kom txo mob thiab txo lub cev kub. Yog lawm, yog tias koj xav tau, koj tuaj yeem siv Thrombo ACC kom qis dua qhov kub thiab txias, tab sis rau qhov no koj yuav tsum tau tam sim ntawd noj tsib ntsiav tshuaj, uas yuav sib npaug hauv qhov ntau npaum li cas rau ib ntsiav tshuaj ntawm cov tshuaj aspirin zoo tib yam. Thiab qhov no yog impractical thiab tsis zoo.

Tab sis kom hloov Trombo ACC nrog cov tshuaj aspirin xwm yeem muaj peev xwm ua tau, txij li cov tshuaj yeeb tshuaj yog ib yam. Tab sis tsuas yog nyob rau hauv cov ntaub ntawv no cov ntsiav tshuaj Aspirin yuav tsum tau muab faib ua plaub ntu lossis eights kom tau txais qhov tshuaj ntawm cov tshuaj acetylsalicylic acid hauv 50-100 mg.

Raws li cov khoom lag luam pabcuam, cov ntsiav tshuaj nrog kev siv tshuaj ntawm 50 mg thiab 100 mg muaj cov tshuaj qub: microcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide thiab cov hmoov txhuv nplej siab. Lub khauj khaum ntawm 100 mg thiab 50 mg ntsiav tshuaj tseem muaj tib lub tshuaj, uas yog: talc, triacetin, tus kws kho mob ntawm methacrylic acid thiab ethyl acrylate (1: 1) (Eudragit L).

Cov ntsiav tshuaj ntawm ob qho tshuaj (50 mg thiab 100 mg) lawv tus kheej tau pleev xim dawb, muaj puag ncig biconvex puab, qhov ci zoo nkauj lossis thaj chaw me ntsis.

Thrombo ACC 100 thiab 50

Heev feem ntau, hauv kev hais lus niaj hnub, kom muaj kev yooj yim, lej ntxiv rau cov npe ntawm cov tshuaj uas txhais tau tias ntau npaum li cas ntawm cov tshuaj yeeb dej caw. Xws li kev tsim kho ntawm cov "tshiab" feem ntau yog txais, yog li cov kws muag tshuaj, kws kho mob, thiab cov neeg mob lawv tus kheej nkag siab lawv. Qhov no siv tag nrho rau Thrombo ACC, thaum cov npe tshiab "Thrombo ACC 100" thiab "Thrombo ACC 50" txhais tau tias tsuas yog ntau npaum ntawm cov ntsiav tshuaj ntawm tib cov tshuaj.

Tsis muaj qhov sib txawv, sib txawv ntawm qhov ntau npaum li cas ntawm cov tshuaj nquag, nruab nrab ntawm Thrombo ACC 50 thiab Thrombo ACC 100, yog li peb yuav tsis xav txog tib hom tshuaj sib cais nrog cov koob tshuaj sib txawv. Ntawm qhov tsis sib xws, hauv cov ntawv sau hauv qab no, txhua cov ntaub ntawv muab yuav txhawj xeeb txog Thrombo ACC ntawm ib qho tshuaj - ob qho 50 mg thiab 100 mg. Thiab yog tias nws yog qhov yuav tsum tau hais txog cov cim tshwj xeeb lossis cov yam ntxwv ntawm qee yam tshuaj, ces peb yuav ua nws lub hom phiaj, tab sis txwv tsis pub txhua yam ntaub ntawv yuav cuam tshuam Trombo ACC hauv ob koob.

Kho nyhuv

Thrombotic ACC muaj cov nyhuv antiplatelet, uas muaj nyob hauv kev txo cov kev nplaum rau ntawm cov ntshav thiab cov ntshav liab. Ntxiv mus, kev coj ua kom yooj yim ntawm cov tau tsim cov ntshav tau txo ob leeg ntawm lawv tus kheej thiab nrog cov phab ntsa ntawm cov hlab ntsha. Vim tias qhov no, cov ntshav tau ua kua ntau dua, tsis yog khov, yooj yim thiab zoo dua rau hauv cov hlab ntsha, tsis stagnate, tsis tsim blockages. Cov nyhuv antiplatelet ntawm Thrombo ACC vim yog kev txhim kho ntawm cov khoom ntws ntawm cov ntshav tseem tuaj yeem tiv thaiv kev tsim cov ntshav txhaws hauv ntau cov hlab ntsha, uas, nyeg, pabcuam tiv thaiv ntau yam mob hnyav los ntawm kev txhaws ntawm cov hlab ntshav los ntawm cov ntshav txhaws (mob plawv, hlab ntshav tawm, thromboses, pulmonary embolism, thiab lwm yam).

Acetylsalicylic acid, uas yog ib feem ntawm Thrombo ACC ua cov khoom xyaw, tam sim no yog ib qho kev tshaj tawm ntawm cov neeg ua haujlwm antiplatelet. Nws cov nyhuv antiplatelet muaj ntau tus txheej txheem. Yog li, acetylsalicylic acid muaj feem cuam tshuam rau kev ua haujlwm ntawm ntau yam enzymes uas txhim kho cov khoom tsim tawm ntawm qee yam thiab inhibit lwm tus.

Ntxiv nrog rau cov nyhuv antiplatelet, acetylsalicylic acid kuj tseem muaj cov nyhuv fibrinolytic, uas muaj nyob rau hauv cov roj ntshav zom uas twb tau tsim thiab qias neeg hauv cov ntshav liab. Acetylsalicylic acid kuj txo qhov kev ua zoo ntawm coagulation yam II, VII, IX, thiab X hauv cov ntshav, uas tseem txo cov tshuaj thrombus.

Rau kev txhim kho ntawm fibrinolytic thiab tshuaj tiv thaiv antiplatelet, acetylsalicylic acid tau noj tsawg koob - 75 - 325 mg rau ib hnub. Yog vim li cas Trombo ACC ntsiav tshuaj tsuas muaj 50 mg lossis 100 mg ntawm acetylsalicylic acid. Qhov ua hauj lwm antiplatelet tseem mob rau ib lub lim tiam tom qab siv ib zaug ntawm Thrombo ACC.

Nws yog cov khoom piav qhia ntawm acetylsalicylic acid uas siv los tiv thaiv thiab kho mob plawv, mob plawv, mob ntshav tawm ntawm cov leeg ntshav thiab lwm yam kab mob uas txaus ntshai rau kev tsim cov ntshav txhaws.

Thaum coj tus thrombo, ACC yog nqus sai thiab tag nrho. Ua tsaug rau cov txheej nkag hauv cov ntsiav tshuaj, lub ntsiav tshuaj tsis muaj qhov tsis zoo khaus thiab ua rau lub plab zom mov. Tom qab tau nkag rau hauv cov ntshav, acetylsalicylic acid hloov mus rau hauv salicylic acid, uas tawm nws cov nyhuv. Ntxiv mus, salicylic acid yog ua kom zoo nyob rau hauv daim siab nrog kev tsim cov phenyl salicylate, salicylate glucuronide thiab salicyluric acid, uas, nyeg, tau faib rau txhua yam plab hnyuv siab raum thiab cov ntaub so ntswg. Salicylic acid kis tau mus rau hauv niam cov kua mis thiab dhau ntawm lub tsho me nyuam. Hauv cov poj niam, kev hloov pauv ntawm acetylsalicylic acid hauv lub cev yog qeeb qeeb dua li txiv neej vim qhov qis qis dua ntawm cov enzymes.

Acetylsalicylic acid yog tawm hauv cov qauv ntawm lub cev ua kom lub cev nyob hauv 24 mus rau 72 teev. Txawm hais tias rov qab ua dua coj los, cov tshuaj tsis txuam nrog hauv cov ntshav cov ntshav.

Yuav noj li cas?

Thrombo ACC ntsiav tshuaj 50 mg thiab 100 mg yuav tsum noj tam sim ntawd ua ntej noj mov, ntxuav nrog cov dej kom ntau - tsawg kawg ib khob (200 ml). Nco ntsoov tias koj tsis tuaj yeem haus Thrombo ACC ntawm lub plab khoob, vim qhov no yuav ua rau voos thiab mob plab. Nco ntsoov noj tam sim ntawd tom qab siv sijhawm thrombotic ACC. Tib lub sijhawm, lo lus "noj" tsis txhais tau tias yog cov pluas su nyuaj, tab sis kev siv tsawg kawg yog qhov tsawg ntawm cov zaub mov uas yuav ntim rau lub plab. Piv txwv li, tom qab noj Thrombo ACC nws txaus los noj ob peb lub txiv tsawb, ib qho qhaub cij, ib qho me me ntawm cov khoom noj me me, zaub xam lav, thiab lwm yam, thiab qhov no yuav txaus kom tiv thaiv kom tsis txhob muaj kev ntxhov siab ntawm cov tshuaj ntawm lub plab.

Trombo ACC ntsiav tshuaj lawv tus kheej yuav tsum tau nqos tag nrho lawv tus kheej, tsis txhob zawm, zom, tsoo lossis tsoo hauv lwm txoj kev.

Raws li txoj cai, thrombo ACC noj ib hnub ib zaug hauv kev noj tshuaj txhua hnub. Nws raug nquahu kom noj cov tshuaj txhua txhua hnub nyob rau tib lub sijhawm - rau qhov no koj tsuas yog yuav tsum xaiv qee qhov tshwj xeeb thaum nruab hnub thiab haus dej haus tshuaj tas li nyob rau lub sijhawm no. Nws yog qhov yooj yim rau ntau tus noj Thrombo ACC ua ntej noj tshais, thaum lwm tus nyiam ua qhov no thaum yav tsaus ntuj ua ntej yuav mus pw. Lub sijhawm ntawm kev noj cov ntsiav tshuaj nyob ntawm tag nrho yooj yim rau tus neeg mob. Tab sis nws yuav tsum nco ntsoov tias thaum twg los xij noj tshuaj kom qaug, tam sim ntawd tom qab koj yuav tsum noj me me ntawm cov khoom noj.

Thrombo ACC ntsiav tshuaj yog npaj rau kev siv lub sijhawm ntev, thiab lub sijhawm kawm ntawm kev kho yog txiav txim los ntawm tus kws kho mob. Qee tus neeg raug xaj ntau ntxiv ntawm Thrombo ACC rau rau lub hlis lossis txawm ntau xyoo, thiab qee tus neeg tau txais kev kawm ntawm peb lub hlis nrog so ntawm 2 txog 4 lub lim tiam ntawm lawv. Tom qab kev khiav haujlwm, Thrombo ACC tuaj yeem tsuas yog rau lub hlis. Tab sis feem ntau, ntau zaus Trombo ACC tau tsim rau lub neej, txij li thaum ib tug neeg muaj kev pheej hmoo ntawm thrombosis thiab txhaws ntawm ntau cov hlab ntsha nrog thrombi, tom qab ntawd nws tsis ploj thiab tseem nyob mus txog thaum nws tuag. Nws yog txhawm rau tiv thaiv kev tsim cov ntshav txhaws thiab txhaws ntawm cov hlab ntshav uas muaj tus neeg muaj tus mob ACC ntev ntev, tshwj tsis yog, ib tus neeg muaj kev pheej hmoo heev ntawm thrombosis.

Dosages rau ntau yam kab mob

Qhov ntau npaum li cas ntawm thrombotic ACC yog nyob ntawm vim li cas cov tshuaj.

Yog li, rau kev tiv thaiv thawj thiab rov ua dua myocardial infarction, Thrombo ACC yuav tsum noj 50-100 mg ib hnub (1 ntsiav tshuaj 50 mg lossis 1 ntsiav tshuaj 100 mg ib hnub ib zaug).

Hauv kev kho ntawm tsis khov thiab ruaj khov angina, thrombo ACC tseem pom zoo kom noj 50-100 mg ib hnub. Yog li, koj yuav tsum haus ib ntsiav tshuaj 50 mg lossis 100 mg ib hnub ib zaug.

Txog kev tiv thaiv cov mob stroke thiab transberebrovascular kev raug mob mus ntxiv, Thrombo ACC pom zoo kom noj 50-100 mg ib hnub (1 ntsiav tshuaj 50 mg lossis 1 ntsiav tshuaj 100 mg ib hnub ib zaug).

Kev tiv thaiv ntawm thromboembolism tom qab kev phais mob thiab tom qab kev tiv thaiv vascular cuam tshuam nrog noj Thrombo ACC ntawm 50 - 100 mg ib hnub (1 ntsiav tshuaj ntawm 50 mg lossis 1 ntsiav tshuaj ntawm 100 mg ib hnub ib zaug).

Txhawm rau tiv thaiv txoj hlab ntsws sib sib zog nqus thiab mob txhaws ntawm txoj hlab ntsws thiab nws cov ceg, Thrombo ACC pom zoo kom noj 100-200 mg ib hnub (1 lossis 2 ntsiav tshuaj ntawm 100 mg ib hnub ib zaug).

Siv thaum cev xeeb tub thiab pub niam mis

Kev siv cov tshuaj acetylsalicylic acid nyob rau thawj peb lub hlis thaum cev xeeb tub tuaj yeem ua rau muaj kev loj hlob ntawm cov menyuam hauv plab, xws li kev sib faib sab saud ("txha hniav sab hauv"), lub plawv tsis muaj zog, thiab lwm yam. Yog vim li cas thiaj li noj tshuaj uas muaj cov tshuaj acetylsalicylic acid, suav nrog Thrombo ACC, yog pom zoo siv thaum thawj 13 lub lis piam ntawm cev xeeb tub.

Noj tshuaj acetylsalicylic acid npaj nyob rau hauv lub koob tshuaj ntau dua 300 mg rau ib hnub los ntawm 27 lub lim tiam ntawm cev xeeb tub thiab ua ntej yug menyuam provokes inhibition ntawm kev ua haujlwm, nce ntshav hauv niam thiab tus menyuam, nrog rau lub sijhawm ua ntej ntawm cov oval qhib lub plawv hauv lub menyuam hauv plab. Txais tos ntawm acetylsalicylic acid tam sim ntawd ua ntej yug menyuam tuaj yeem ua rau mob ntshav liab rau tus menyuam yug tshiab, tshwj xeeb yog cov menyuam hauv lub cev tsis ntev. Yog vim li cas thiaj li noj ib qho tshuaj twg uas muaj acetylsalicylic acid nyob rau lub hlis thib peb ntawm cev xeeb tub yog txwv tsis pub.

Lub sijhawm zaum ob ntawm lub sijhawm cev xeeb tub, uas yog hnub tim 14 txog rau 26 lub limtiam, suav nrog, Trombo ACC tuaj yeem tsuas yog ua rau cov kev ntsuas nruj, thaum nws tseem ceeb heev rau cov menyuam uas tseem tos, thiab yog tias cov txiaj ntsig tau dhau txhua qhov txaus ntshai. Nyob rau lub caij nyoog thib ob ntawm cev xeeb tub, kev siv thrombo ACC hauv cov chav kawm luv luv yog qhov tso cai.

Acetylsalicylic acid thiab nws cov keeb kwm kis mus rau niam mis. Tab sis kev tswj hwm kev sib tsoo ntawm cov tshuaj acetylsalicylic acid feem ntau tsis ua rau muaj kev mob tshwm sim los yog muaj teeb meem hauv cov menyuam mos, vim qhov ntawd tau muaj tus mob thrombo ACC thaum pub mis niam. Txawm li cas los xij, yog hais tias Trombo ACC noj ntev, yog li kev pub mis niam tseem zoo dua kom thim thiab hloov cov menyuam mus rau cov khoom siv sib tov.

Kev cuam tshuam nrog lwm yam tshuaj

Thrombotic ACC, thaum siv ua ke, txhim kho cov nyhuv ntawm cov tshuaj hauv qab no:

• Methotrexate (tsis tshua muaj nthuav tawm ntawm methotrexate los ntawm ob lub raum),
• Anticoagulants (Heparin, Warfarin, thiab lwm yam), thrombolytics (Urokinase, Fibrinolysin, thiab lwm yam) thiab lwm cov tshuaj tiv thaiv antiplatelet (Clopidogrel, Curantil, thiab lwm yam). Thaum noj nrog Trombo ACC, cov kev puas tsuaj los ntawm cov leeg ntawm lub plab thiab plab hnyuv nce, thiab kev pheej hmoo ntawm los ntshav nce,
• Xaiv cov serotonin reuptake inhibitors (Fluoxetine, Venlafaxine, Elicea, Valdoxan, Flunisan, Oprah, thiab lwm yam) - kev pheej hmoo los ntshav los ntawm lub plab thiab txoj hlab pas nce,
• Digoxin - nws cov kev nthuav tawm los ntawm ob lub raum yog txo qis, uas tuaj yeem ua rau nws muaj kev xav ntau dhau,
• Cov tsim tawm ntawm sulfonylureas los txo cov ntshav qab zib (Glibenclamide, Glycvidone, Glyclazide, Glimepiride, Glipizid, Chlorpropamide, Buformide, Nateglimide, thiab lwm yam) - cov ntshav qabzib tuaj yeem txo qis ntau, vim Thrombo ACC kuj me ntsis txo nws cov kev xav,
• Valproic acid kev npaj (Konvuleks, Depakin, Dipromal, Valparin XP, thiab lwm yam) - cov tshuaj lom ntawm valproate nce,
• Cawv dej cawv thiab tshuaj muaj cawv - muaj kev pheej hmoo ntawm kev puas tsuaj rau lub plab ntawm lub plab thiab lub plab hnyuv nce, thiab lub sijhawm los ntshav tseem lengthens,
• Nonsteroidal anti-inflammatory tshuaj (Diclofenac, Nimesulide, Indomethacin, Meloxicam, thiab lwm yam) thiab lwm yam tshuaj salicylates (Salofalk, thiab lwm yam) - qhov kev pheej hmoo ntawm kev txhim kho mob plab thiab duodenal mob rau sab hauv thiab los ntshav ntxiv.

Muab qhov tseeb tias qhov kev txiav txim ntawm cov tshuaj saum toj no tau txhim kho thaum coj lawv nrog Thrombo ACC, koj yuav tsum xav txog kev txo lawv cov tshuaj thaum lawv noj nrog Thrombo ACC.

Siv tib lub sijhawm ntawm Thrombo ACC nrog cov tshuaj hauv qab no txo ​​lawv cov txiaj ntsig (yog li ntawd, kev nce ntxiv rau lawv ntau npaum li tsim nyog):

• Ib qho tshuaj diuretic (nyob rau hauv qhov kev txiav txim ntawm Thrombo ACC, tus nqi ntawm kev lim ntshav ntawm cov zis los ntawm ob lub raum poob qis),
• Cov tshuaj tiv thaiv ntawm angiotensin-hloov pauv enzyme (Captopril, Kapoten, Perineva, Prenessa, Enalapril, thiab lwm yam) - cov nyhuv ntawm cov tshuaj tiv thaiv ntawm kev txo cov ntshav siab yog tsis muaj zog thiab lawv cov nyhuv cardioprotective yog qib. Feem ntau, qhov txo qis ntawm qhov hnyav ntawm qhov kev txiav txim ntawm angiotensin-hloov enzyme inhibitors yog pom thaum lawv coj ua ke nrog Thrombo ACC hauv koob tshuaj ntau dua 160 mg rau ib hnub,
• Cov tshuaj uas txhim kho qhov tsis pom ntawm uric acid (Probenecid, Benzbromaron) - lawv cov nyhuv poob qis vim tias lub raum qeeb qeeb,
• Cov tshuaj glucocorticoid cov kab ke (prednisone, dexamethasone, thiab lwm yam) - qhov kev nthuav tawm ntawm thrombo ACC yog qhov muaj txiaj ntsig zoo, thiab lawv cov nyhuv tsis muaj zog.

Sab sij huam

Thrombo ACC feem ntau muaj kev tiv thaiv zoo thiab, vim tias qhov ntau npaum li cas ntawm acetylsalicylic acid, tsis ua rau muaj kev phiv. Txawm li cas los xij, hauv qee qhov tsis tshua muaj tshwm sim, thrombo ACC tseem tuaj yeem ua rau kev txhim kho ntawm ntau yam kev mob tshwm sim hauv qab no los ntawm cov kabmob sib txawv thiab cov tshuab:

1. Los ntawm txoj hnyuv plab hnyuv:

• Xeev siab
• Ntuav
• Kev mob siab
• Mob plab
• Mob plab lossis duodenal mob,
• Lub plab zom mov txhaws ntshav
• Lub siab ua rau lub siab ib ntus nrog kev ua si ntau ntxiv ntawm aspartate aminotransferase (AcAT) thiab alanine aminotransferase (AlAT).

2. Los ntawm nruab nrab hauv lub paj hlwb:

• Kiv taub hau
• Hnov hnov ​​lus tsis zoo
• Tinnitus.

3. Los ntawm cov kab mob hematopoietic:

• Tshaj ntshav los ntshav thaum lub sijhawm thiab tom qab phais mob,
• Nquag Hematoma tsim,
• Nquag nquag qhov ntswg
• Cov pos hniav los ntshav
• Qhov chaw mos los ntshav
• Cerebral hemorrhages (muaj kev pheej hmoo siab rau cov neeg mob uas siv Warfarin lossis lwm yam tshuaj anticoagulants tib lub sijhawm, lossis tsis tswj ntshav siab, tab sis nws feem ntau nce),,
• Mob hnyav los yog mob hlab ntsha ntev posthemorrhagic lossis hlau tsis muaj zog vim muaj ntshav tawm tsis tseeb.

4. Los ntawm sab tiv thaiv cov tsis muaj zog:

• Cov tawv nqaij ua pob
• Cov tawv nqaij khaus
• Urticaria,
• Quincke's edema,
• Kev ua xua rau rhinitis
• Cov pa hauv qhov ntswg (mob hauv qhov ntswg),
• Bronchospasm (qhov muaj zog nqaim ntawm lub lumen ntawm bronchi nrog qhov tshwm sim ntawm qhov hnov ​​ntawm txhaus ntawm txhawm chim),
• Cov mob plawv-pa nyuaj
• Anaphylactic poob siab.

Yuav ua li cas coj thrombo ACC - ua ntej lossis tom qab noj mov?

Tom qab mus ntsib kws kho mob, tus neeg mob tshawb pom lub npe tshiab rau cov tshuaj hauv cov npe tshuaj. Tom ntej no, feem ntau, cov lus hais luv luv tau muab txuas nrog, qhia txog tus nqi ntawm ib koob ntawm cov tshuaj, khoo tus naj npawb ntawm cov koob tshuaj hauv ib hnub. Qee qhov xwm txheej, cov ntaub ntawv no muaj ntau txaus, tab sis tsuas yog tsis yog thaum koj xav noj TromboASS.

Yog lawm, koj tuaj yeem pom hauv cov lus qhia yuav ua li cas noj Thrombo ACC ntsiav tshuaj rau cov ntshav ntshav, muaj ib ntu ntu - "kev siv", qhia tias thaum twg ua qhov no, ua ntej lossis tom qab noj mov. Tab sis tsis kom cem cov compilers, cov lus qhia zoo li no yog tsim rau cov pej xeem hauv nruab nrab uas tsis muaj. Tom ntej no, cov npe ntawm contraindications hauv qab no, qhov twg yuav luag txhua tus neeg pom tsawg kawg ib ntawm nws "mob".

Tom qab ntawd, kev tsis txaus siab txog qhov tsis saib xyuas, thiab txawm tias kev tsis saib xyuas ntawm tus kws kho mob koom, pib. Tshwj xeeb tshaj yog kev npau taws yog "ventricles," thiab ntawm nws tus kheej hloov mus rau cov analogues uas tsis muaj cov kua qaub.

Yog li leej twg tsis ncaj ncees lawm? Tus kws kho mob? Los yog tus kws tshaj lij uas sau daim ntawv xa nrog cov tshuaj no? Cov lus teb tuaj yeem nrhiav tau los ntawm kev xa mus rau cov lus qhia nyob rau hauv ntu qhov twg muaj pes tsawg leeg ntawm ib ntsiav tshuaj tau piav qhia txhua yam.

Dab tsi yog suav nrog hauv kev npaj ntawm thromboass?

Qhov feem pua ​​tseem ceeb ntawm cov tshuaj no, tau kawg, yog acetylsalicylic acid. Qhov no yog li cas cov neeg mob kev txom nyem los ntawm kev mob plab thiab mob plab tsis kam yuav.

Tab sis peb yuav tsum tsis txhob hnov ​​qab tias, tsis zoo li niaj zaus ASK tau muag hauv cov chaw muag tshuaj, TromboAX ntshav cov ntsiav tshuaj txhaws yog nrog lub plhaub hauv cov khoom sib xyaw xws li talc thiab eudragit tam sim no.

sc lub npe = "info2 ″ ntawv nyeem =" Hauv lub molecular ntim ntawm talc, uas yog ib feem ntawm lub plhaub, muaj magnesium - ib qho khoom uas nruab nrab cov kev cuam tshuam ntawm ASA ua rau lub epithelium ntawm lub plab. "

Eudragits yog derivatives ntawm lub polymerization ntawm acrylic acid. Lawv ua cov haujlwm ntawm thauj cov tshuaj mus rau ib qhov tshwj xeeb tau teev tseg ntawm txoj hnyuv, tiv thaiv nws los ntawm kev cuam tshuam ntawm lub plab cov kua qaub thiab kev nqus sai.

Tab sis tseem, kev qhia meej txog contraindications yog qhov tsim nyog. Qhov no yog "qhov xwm txheej pov hwm" thaum tus neeg mob, tsis tau ploj, "tsis nyob hauv plab" thiab "tsis tau zom", mus ncig "nrog kev ceev faj" thiab "tsis pom zoo."

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Cov enteric-coated thrombopol ntsiav tshuaj, liab dawb hauv cov xim, muaj cov khoom xyaw nquag hu ua Acidum acetylsalicylicum. Raws li kev txheeb xyuas ntawm Trombopol, ib cov tshuaj uas muaj puag ncig yog nthuav tawm hauv cov tshuaj hauv qab no - xya caum-tsib thiab ib puas thiab tsib caug milligrams. Raws li cov khoom xyaw pabcuam, cov chaw tsim khoom siv cov hmoov txhuv nplej siab, MCC, atria amylopectin glycolate. Lub plhaub muaj ntau yam khoom siv - Hypromellosum, sib xyaw tshwj xeeb rau txheej tshuaj nrog E553b, khoom noj khoom haus ntxiv E171, triethyl citrate, xim teeb meem, Silicii dioxideydum colloidale, Natrii hydrocarbonas, sodium lauryl sulfate. Tus nqi nruab nrab ntawm Trombopol yog 51 rubles. Cov ntaub ntawv hais txog kev muaj cov tshuaj tuaj yeem tau hauv xov tooj lossis hauv lub vev xaib ntawm cov neeg xa khoom.

Tau ntsia hauv qab lub plhaub, koj tuaj yeem pom tau tias ntxiv rau ACS, cov tshuaj yeeb yaj kiab muaj xws li:

• lactose
• cellulose
• silicon
• cov hmoov txhuv nplej siab.

Lactose tsim ib qho chaw ua zes qe rau lactobacilli, ua kom lub cev muaj zog ntawm cov hnyuv microflora. Cellulose ntxuav cov hnyuv ntawm co toxins. Silicon khi thiab tshem tawm cov bilirubin tawm ntawm lub cev, thiaj li ua kom cov ntshav. Qos yaj ywm hmoov txhuv nplej siab txo qis acidity thiab txhawb kev tiv thaiv.

sc lub npe = "info2 ″ text =" Xav paub, cov ntsiab lus ntawm cov tshuaj nyob rau hauv ib lub ntsiav tshuaj yog me me. Tab sis muab hais tias cov tshuaj yog kws kho, raws li txoj cai, rau ib lub sijhawm ntev, cov nyiaj tau rov txiav txim dua thiab twb muaj teeb meem. ”

Txheeb meej txog lub ntsiab lus ntawm txhua cov tshuaj, peb rov qab los rau cov lus nug tseem ceeb. Yuav ua li cas siv tshuaj thromboass, thiab nws yog qhov tseem ceeb tiag thaum noj cov tshuaj - ua ntej lossis tom qab noj mov?

Puas muaj cov nyhuv thinning ntawm cov ntsiav tshuaj nyob ntawm qhov ntau, qhov zoo thiab lub sijhawm ntawm kev noj zaub mov?

Kev tshawb nrhiav ntawm qhov teeb meem no tau qhia:

1. Lub ntsiab ntawm ASA yog nqus hauv cov hnyuv me, lossis theej, hauv nws lub siab.
2. Lub sijhawm nqus tau tsis yog nyob ntawm qhov neeg kawm ntawv ntawm lub plab tag nrho.
3. Cov tshuaj tiv thaiv kab mob uas txo qis acidity ntawm lub plab ua kua tsis cuam tshuam rau qhov ceev ntawm lub cev qhov kev cia siab ntawm cov tshuaj. Ib qho tuaj yeem hais tau txog mis nyuj thiab lwm yam khoom muaj cov tsiaj rog.

Ib zaug ntxiv, peb tig mus rau cov lus qhia, uas nws tau hais tias Thrombo ACC ntsiav tshuaj yuav tsum tau noj ua ntej noj mov, tab sis tsis yog rau ntawm lub plab khoob. Nrog rau qhov tseeb tias cov zaub mov tsis cuam tshuam rau hauv cov dej num ntawm cov tshuaj, cais tawm.

Nws tseem nkag siab txog qhov "tsis nyob hauv plab khoob" txhais tau li cas?

Tsis txhob haus tshuaj tam sim ntawd tom qab tsaug zog. Lub plab kuj tseem xav tau sijhawm los ua kom muaj kev ua si. Yog tias, vim qee lub sijhawm, thawj ib nrab ntawm ib hnub yog qhov kev xaiv zoo tshaj plaws rau kev siv tshuaj kho mob, ces koj yuav tsum xub noj ib yam dab tsi. Cia nws yog qhov tsawg tshaj plaws ntawm cov zaub mov, tab sis nws yuav pab lub plab raws li cov lus txib - "pib".

Thromboass rau kev ua kom cov ntshav hauv cov ntshav, noj "lub plab", uas tsis muaj kev noj zaub mov ntxiv, muaj kev pheej hmoo hauv lub plab. Nrog rau kev ua kom ib puag ncig acidity, lub ntsiab ntawm ASA yuav nyob hauv cov kua qaub, txhim kho cov kev ua tsis zoo nyob rau epithelial hlwb. Nrog txo acidity ntawm lub plab, ASA yog nqus rau hauv cov phab ntsa ntawm cov zom zaub mov thiab tsub zuj zuj hauv cov hlwb ntawm cov roj ntsha ntawm daim nyias nyias, uas tsis yog txhua qhov kev ntshaw.

sc lub npe = "cov ntaub ntawv" ntawv nyeem = "Koj yuav tsum noj Tromboass ntawm qhov chaw nruab nrab, uas tsis tuaj yeem hais tias nws yog" tom qab noj mov ", lossis" ua ntej. "

Raws li koj tuaj yeem nkag siab, tag nrho cov kev ceev faj no tau cuam tshuam, rau feem ntau, nrog kev tiv thaiv ntawm lub plab zom mov, los ntawm qhov tsis zoo ntawm ASA, thiab tsis cuam tshuam rau cov nyhuv ntawm cov tshuaj thinning.

Ib cov ntshav ua haujlwm txawv li cas?

Nqa rau hauv cov phab ntsa hauv cov hnyuv, cov tshuaj lom neeg ntawm cov tshuaj nkag mus rau cov hlab ntshav thiab khi rau nws cov protein. ASA yog tus cim los ntawm kev tso rau sab nraum lub hlwb. Tab sis kuj tseem cuam tshuam nrog cov protein, nws tsis plam nws cov haujlwm.

ASA neutralizes thromboxane - ib qho enzyme uas zais los ntawm platelets qhib, uas ua haujlwm ua lub teeb liab rau kev ua kom lwm cov platelets. Cov ntshav plob tsis txaus, txog thaum kawg ntawm lawv lub neej kev ua haujlwm, poob lawv lub peev xwm los sib sau ua ke, uas yuav pab ua kom cov ntshav khov.

Ib qho cuab yeej nthuav ntawm ASA uas muaj nyob hauv cov tshuaj yog tias cov tshuaj yuav tsis raug kuaj xyuas txhua qhov hauv cov ntshav ntshav (lossis pom nyob hauv cov ntshav me me). Tab sis, txawm li cas los xij, cov nyhuv inhibitory rau platelet muaj nuj nqi yuav muaj kev cuam tshuam tag nrho.

sc lub npe = "cov ntaub ntawv" ntawv nyeem = "Raug metabolized hauv lub siab mob hlwb, ASA teeb tsa" kev tua "ntawm cov platelets ntawm no. "Cov kab mob siab nqa mus rau lawv nyob ntawm no, qhov chaw uas lawv tau puv nrog qhov tshuaj puv ntawm cov tshuaj."

Tawm tsam keeb kwm yav dhau los ntawm kev txo qis hauv qib ntawm thromboxane, cov ntsiab lus ntawm prostacyclin, uas yog tus neeg thaiv kev tawm tsam ntawm platelet activation enzyme, nce hauv cov ntshav. Yog li, qhov tsim nyog thiab xav kom ua tiav tau tiav - ntshav ntshav.

Txij li nws pom zoo kom noj Thrombo ACC kom nyias cov ntshav, ntxuav hauv cov ntsiav tshuaj nrog dej kom ntau lossis lwm yam kua, qhov no paub tseeb lub sijhawm ntawm kev nqis tes ua - ua ntej noj mov, thiab tsis yog tom qab. Khoom noj khoom haus, nrog kev sib txawv loj ntawm cov tshuaj ua kua, ua rau lub plab ua haujlwm thiab lub siab ntev hauv nws ntev dua.

Raws li txoj cai, tus kws kho mob sau ib daim ntawv ntawm cov tshuaj, nrog rau kev pom zoo yav tsaus ntuj. Hauv qhov no, ib qho yuav tsum tsis txhob saib ib qho kev zais sib luag ntawm cov kev sib luag ntawm lub cev lossis lwm yam laj thawj.

Lub sijhawm hmo, ua ntej noj hmo, tseem ceeb dua los ntawm qhov kev xav ntawm lub hlwb. Nov yog lub sijhawm thaum nruab hnub txhawj txog, maj, tsis pom kev twb kov yeej lawm. Lub cev, nrog rau lub hlwb, tau txais kev so luv los ntawm kev txhawj xeeb sab nraud thiab tuaj yeem tsom nws tus kheej. Nov yog qhov xwm txheej zoo tshaj plaws rau kev noj tshuaj kom raug.

sc lub npe = "info2 ″ ntawv nyeem =" Qhia tias tag nrho cov kab ntawv tau pom, cov tshuaj yuav tsis tsuas yog tsis muaj kev cuam tshuam tsis zoo rau lub cev, tab sis tag nrho cov khoom tsis zoo yuav raug tshem tawm tiav. "

Yog tias tus neeg mob tau ua xyem xyav txog qhov tsis haum ntawm cov tshuaj. Yog tias thaum kho mob cov tsos mob tshwm sim hauv plab, xeev siab, kiv taub hau, tsis muaj zog. Koj yuav tsum hu rau koj tus kws kho mob sai.

Tsis muaj qhov xwm txheej, koj yuav tsum tsis txhob hloov ntawm nws tus kheej qhov ntau npaum li cas ntawm cov tshuaj lossis hloov hloov ThromboASS nrog analogues. Qhov no yog qhov tseem ceeb ntawm cov kws tshaj lij uas muaj cov ntsiab lus qhia txog cov xwm txheej ntawm tus neeg mob lub cev, suav los ntawm kev tshuaj xyuas thiab ntsuas, suav txog txhua yam kev pheej hmoo.

Pharmacological kev txiav txim

Cov kev tshawb fawb soj ntsuam tau pom tias, zoo li nws txoj kev ua haujlwm, thuv thiav pov tseg sai sai los ntawm cov hnyuv plab. Acidum acetylsalicylicum muaj cov cuab yeej ntawm kev hloov pauv mus rau phenolic acid. Qhov siab tshaj plaws ntawm acetylsalicylic acid nyob rau hauv cov ntshav ntshav tau sau tseg hauv nruab nrab kaum tsib feeb tom qab noj cov tshuaj, cov metabolite nquag nce mus txog qhov siab tshaj plaws nyob rau hauv peb caug mus rau ib puas thiab nees nkaum feeb. Vim tias qhov nce ntxiv ruaj khov ntawm cov ntsiav tshuaj plhaub, qhov tso tawm ntawm qhov nquag ua haujlwm ntawm cov tshuaj tshwm sim hauv cov hnyuv. Cov cuab yeej no ntawm nws ua rau muaj qhov cuam tshuam ntau ntxiv ncua ntev - ntawm 180 txog 360 feeb. Ob lub tshuab sib xyaw ua ke thiab cov khoom siv tiv thaiv nquag tau muaj cov cuab yeej ntawm khi rau cov ntshav plasma. Tsis tas li, cov kab mob uas tau teev tseg yog pom los ntawm kev faib tawm sai hauv cov ntaub so ntswg. 2-hydroxybenzoic acid muaj cov cuab yeej ua nyob hauv niam mis. Cov txiaj ntsig ntawm kev sim pom tau hais tias cov metabolite nkag mus rau ntawm qhov chaw tiv thaiv tsis zoo. Nws qhov kev tshem tawm yog nyob ntawm cov tshuaj muab tshuaj. Nrog rau yam tsawg kawg ntawm cov tshuaj, ib nrab-lub neej yuav siv sijhawm los ntawm 120 txog 180 feeb. Thaum siab ntau npaum li cas, T1 / 2 yog kaum tsib teev. Qhov kev tawm ntawm salicylic acid feem ntau tshwm sim los ntawm lub raum. Koj tuaj yeem yuam kom thrombopol remotely. Cov nquag muaj cov yam ntxwv li nram no: • inhibits platelet aggregation, • inhibits cov synthesis ntawm thromboxane A2. Tseem muaj cov lus qhia ntawm lwm txoj hauv kev ntawm Acidum acetylsalicylicum ntawm platelet pooling, yog li cov tshuaj siv kom nquag kho ntau yam vascular cuam tshuam. NSAIDs nyob hauv lawv, thiab acetylsalicylic acid muaj qhov cuam tshuam ntau: • daws qhov mob, • txo qhov sov, • tshem tawm qhov mob. Kev mob siab rau ntawm cov tshuaj tiv thaiv nquag, raws li tau piav qhia hauv qhov kev piav qhia, yog siv rau kev mob khaub thuas ua pa, nrog rau tus mob khaub thuas kom tiv thaiv cov tsos mob li nram no: • mob, mob hauv pob qij txha thiab cov leeg, • hauv cov kab mob nrog cov txheej txheem ua mob rau hauv daim ntawv mob lossis mob ntev, suav nrog mob caj dab thiab ankylosing spondylitis.

Thrombopol, raws li tau qhia los ntawm cov lus qhia, tau sau tseg rau cov neeg mob uas muaj cov kabmob li nram no: • mob angina pectoris ntawm kev tsis ruaj khov, • raws li kev tiv thaiv mob hlwb, tshwj xeeb tshaj yog rau cov neeg mob ntshav siab ntawm lub hlwb, nyob rau hauv daim ntawv hloov chaw, • tiv thaiv AMI, tshwj xeeb tshaj yog tias keeb kwm muaj ib qho ntawm cov teeb meem tseem ceeb - ntshav qab zib, ntshav siab, kev coj tsis zoo, suav nrog kev haus luam yeeb, rau cov neeg mob ntawm pawg hnub nyoog laus (txij 65 xyoo), dyslipidemia, muaj mob ntau zaus ntawm MI, • cuam tshuam kos mob txhaws ntawm ib txog hlab ntsha los ntawm ib tug thrombus, mus tawg tam sim ntawd los ntawm lawv qhov chaw ntawm kev kawm ntawv, tshwj xeeb tshaj yog tom qab phais los yog tus vascular, pulmonary embolism • kev tiv thaiv, • cov kev tiv thaiv ntawm mob-pib mob nyob rau hauv lub hlwb muaj nuj nqi ntawm vascular keeb kwm, manifested focal, cerebral los yog mixed cov tsos mob.

Tsuas tshuaj thiab tswj hwm

Trombopol yog rau kev siv ntawm qhov ncauj. Cov chaw tsim tshuaj lag luam pom zoo kom noj cov tshuaj hauv daim ntawv tom qab noj mov, tsis tas yuav rhuav tshem nws txoj kev ncaj ncees. Qhov ntau npaum li cas, nrog rau kev kho mob, yog txiav txim siab raws tus neeg mob lub keeb kwm thiab qhov mob hnyav: 1. Yog tias ib tus neeg MI xav tias nyob rau theem mob, ntawm ib puas thiab tsib caug mus rau peb puas milligrams ntawm cov tshuaj yeeb dej caw ua tshuaj tau sau tseg. Cov neeg tsim khoom lag luam pom zoo ntxo thawj cov ntsiav tshuaj thaum thawj cov tsos mob tshwm sim. Kev ua txhaum ntawm kev nkag ntawm cov hnoos qeev yuav ua rau nrawm nrawm ntawm cov tshuaj. Lub hlis tom ntej, cov neeg mob yuav tsum noj li 75 txog 300 milligrams ib hnub twg. Tom qab qhov kev kho mob zoo li no, cov kws kho mob koom nrog yuav tsum xav txog kev tswj hwm tshuaj ntxiv, txhawm rau tiv thaiv cov mob tshiab ntawm tus kab mob. 2. Rau cov neeg mob uas tau ntsib MI, kom txo qis kev pheej hmoo, nrog rau kev ua kom cov neeg tuaj yeem ua rau tuag taus, ntau npaum li cas ntawm cov tshuaj tau hais hauv thaj tsam 75-300 milligrams. 3. Nrog lub npe hu ua angina pectoris ntawm hom tsis ruaj khov thiab tsis khov, koj yuav tsum muaj li ntawm xya-tsib mus rau peb puas milligrams ntawm cov tshuaj nquag ib hnub. 4. Cov neeg mob uas muaj kev pheej hmoo rau kev loj hlob ntawm cov tsos mob ntawm MI nyob rau hauv kev mob hnyav nrog ntshav qab zib, ntshav siab, rog, thiab tseem nyob rau lub hnub nyoog laus yog pom zoo kom noj ib puas thiab tsib caug milligrams ntawm cov nquag tiv tauj ib hnub lossis peb puas milligrams txhua lwm hnub. 5. Txhawm rau tiv thaiv kev txhim kho theem nrab ntawm tus mob stroke, koj yuav tsum muaj li ntawm xya-tsib mus rau peb puas milligrams ntawm lub nquag ua haujlwm nruab hnub. 6. Kev siv tshuaj zoo sib xws txhua hnub yog siv los kho cov neeg mob nrog cov tsos mob ntawm kev hloov pauv ischemic nres, nrog rau cov kev mob concomitant mob hnyav thiab raws li lub cev tiv thaiv kom tsis txhob txhaws ntawm cov hlab ntshav los ntawm cov ntshav khov uas tau los ntawm nws qhov chaw ntawm kev tsim tom qab kev phais thiab tus txheej txheem sib kis. 7. Koj tuaj yeem tiv thaiv DVT thiab thromboembolism nrog Trombopol ntawm kev noj tshuaj li ntawm 75 txog 200 milligrams ib hnub. Lwm hom kev kho mob kuj raug tso cai, siv peb puas milligrams txhua txhua hnub. Tso rau nws, raws li txoj cai, tom qab phais mob loj. Hauv cov neeg mob uas lub cev tsis ua hauj lwm lub raum thiab mob siab ua mob me thiab mob hauj sim, koob tshuaj yuav tau kho kom haum.Koj tuaj yeem yuav Trombopol ntawm lub khw muag khoom sib txuas ntawm cov khw muag tshuaj thiab cov koom haum online.