Ncos Amoxicillin: cov lus qhia rau kev siv > Kev khomob thiab kev tiv thaiv

Amoxicillin: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Amoxicillin

ATX Code: J01CA04

Cov tshuaj uas nquag: amoxicillin (amoxicillin)

Tus tsim tawm: Biochemist, OJSC (Russia), Dalhimpharm (Russia), Organika, OJSC (Russia), STI-MED-SORB (Russia), Hemofarm (Serbia)

Hloov kho cov lus piav qhia thiab yees duab: 11.26.2018

Cov nqi hauv khw muag tshuaj: los ntawm 30 rubles.

Amoxicillin yog ib qho tshuaj tiv thaiv tshuaj tua kab mob, tshuaj tua kab mob semisynthetic penicillin.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Tsim cov qauv Amoxicillin:

ntsiav tshuaj: yuav luag dawb lossis dawb, tiaj-cylindrical, nrog faib kab thiab chamfer (10 pcs. lossis 20 pcs. hauv cov hlwv, hauv ib daim ntawv thawv los ntawm 1, 2, 5, 10, 50 lossis 100 pob, 24 pcs. cov xim dub khob iav, hauv ib daim ntawv thawv los ntawm daim 1 tuaj yeem, 20 pcs. hauv cov poom polymer los yog lub raj mis, hauv pob ntawv tuab ntawm 1 tuaj yeem lossis lub raj mis),
tsiav tshuaj: gelatinous, ntawm koob tshuaj 250 mg - loj No. 2, nrog lub kaus mom ntsuab tsaus thiab dawb nrog lub cev tint daj, ntawm koob tshuaj 500 mg - loj No. 0, nrog lub hau liab thiab lub cev daj, sab hauv tsiav tshuaj yog hmoov ntau xim nrog xim los ntawm lub teeb daj rau dawb, nws cov clumping tso cai (250 mg txhua: 8 pcs. hauv cov hlwv, hauv ib daim duab cardboard 2 blisters, 10 pcs. hauv blisters, hauv cardboard bundle 1 lossis 2 pob, 10 lossis 20 pcs. nyob rau hauv ib lub kaus poom, hauv ib daim ntawv qhwv ib pob 1 ua tau, 500 mg txhua: 8 pcs. hauv blisters, hauv duab los qhia 2 pob khoom, 8 pcs. urnyh sawv hlwv nyob rau hauv ib tug duab los qhia pob 1 los yog pob 2, 10 pcs. nyob rau hauv cov hlwv nyob rau hauv ib tug thawv thawv 1, 2, 50 los yog 100 packs)
granules rau qhov ncauj raug tshem tawm: cov hmoov ntau los ntawm dawb nrog lub daj tint rau dawb, tom qab yaj tag hauv dej - lub txim daj muaj daj nrog tus ntxhiab tsw (40 g txhua qhov hauv lub khob tsaus ntim nrog lub peev xwm ntawm 100 ml, hauv ib daim ntawv cardboard 1 lub raj mis hauv ib pawg) nrog ntsuas ntsuas nrog qhov sib faib ntawm 2.5 ml thiab 5 ml).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: amoxicillin trihydrate (hauv amoxicillin) - 250 mg lossis 500 mg,
Cov khoom xyaw pabcuam: cov hmoov txhuv nplej siab, magnesium stearate, polysorbate-80 (kaum-80), talc.

1 tshuaj ntsiav muaj:

cov tshuaj nquag: amoxicillin trihydrate - 286.9 mg lossis 573.9 mg, uas sib haum rau cov ntsiab lus ntawm 250 mg lossis 500 mg ntawm amoxicillin,
Cov khoom siv pabcuam: microcrystalline cellulose PH 102, magnesium stearate, titanium dioxide (E171), gelatin.

Tsis tas li ntawd, ua ib feem ntawm lub plhaub taum:

qhov loj me 2: cap - quinoline daj zas xim (E104), indigo carmine (E132), rooj plaub - quinoline daj zas xim (E104),
qhov loj me 0: cap - zas xim tshav ntuj hnub poob daj daj (E110), zas azorubine (E122), lub cev - zas hlau oxide daj (E172).

Hauv 5 ml ntawm qhov kev ua tiav (2 g ntawm granules) muaj:

cov tshuaj nquag: amoxicillin trihydrate (hauv amoxicillin) - 250 mg,
Cov khoom siv pabcuam: sodium saccharinate dihydrate, sucrose, simethicone S184, sodium benzoate, guar ntawm cov pos hniav, sodium citrate dihydrate, strawberry tsw, tsw raspberry, noj tau yooj yim passionflower tsw.

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog ib qho tshuaj tiv thaiv penicillin ib nrab, tshuaj tua kab mob tua kab mob nrog kev tiv thaiv dav nrog kev ua. Lub tshuab ntawm kev ua yog vim muaj lub peev xwm ntawm amoxicillin ua rau cov kab mob lysis, tiv thaiv transpeptidase thiab cuam tshuam kev cuam tshuam ntawm cov protein siv ntawm phab ntsa ntawm peptidoglycan thaum lub sijhawm faib thiab kev loj hlob.

Gram-positive thiab gram-tsis zoo microorganisms qhia kev rhiab siab rau cov tshuaj.

Amoxicillin ua haujlwm nyob rau hauv cov kab hauv qab no:

Cov kab mob aerobic gram-zoo: Corynebacterium tshwj xeeb (spp.), Staphylococcus spp. (tshwj tsis yog cov kev tsim cov tshuaj penicillinase), Bacillus anthracis, Listeria monocytogenes, Enterococcus faecalis, Streptococcus spp. (suav nrog tus mob Streptococcus pneumoniae),
aerobic gram-cov kab mob tsis zoo: Brucella spp., Bordetella pertussis, Shigella spp., Escherichia coli, Klebsiella spp., Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Salmonella spp., Vibrio cholerae, Proteusus, Proteus
Lwm tus: Leptospira spp., Clostridium spp., Borrelia burgdorferi, Helicobacter pylori.

Cov kab mob me me uas tsim tawm penicillinase thiab lwm yam beta-lactamases tsis rhiab rau cov tshuaj, vim tias beta-lactamases txov amoxicillin.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, amoxicillin nrawm thiab yuav luag tiav (93%) nqus tau. Kev tshem tawm tsis cuam tshuam los ntawm kev noj zaub mov ua ke, cov tshuaj tsis raug rhuav tshem hauv cov kua qaub acid ntawm lub plab. Qhov siab tshaj plaws tau nce mus txog tom qab 1-2 teev thiab suav nrog 0.0015-0.003 mg / ml tom qab koob ntawm 125 mg thiab 0.0035-0.005 mg / ml tom qab koob ntawm 250 mg. Cov txiaj ntsig kho pib pib ua haujlwm hauv 1 / 4–1 / 2 teev thiab kav ntev txog 8 teev.

Nws muaj cov ntawv xa khoom loj. Qhov kev txiav txim siab nce siab hauv kev faib ua feem rau cov koob tshuaj. Muaj ntau ntau ntawm amoxicillin pom nyob rau hauv ntshav, ntshav dej pleural thiab peritoneal, hnoos qeev, txhawm rau lub ntsej muag, mob ntsws thiab mob pob txha, plab hnyuv tawm, tso zis, mob caj pas, tus poj niam lub cev, mob adipose nqaij, pob ntseg hauv nruab nrab, thiab cov tawv nqaij ua pa. Nws nkag rau hauv cov menyuam mos cov ntaub so ntswg, nrog lub siab ua haujlwm zoo - mus rau hauv lub zais zis, qhov chaw nws cov ntsiab lus muaj peev xwm dhau ntshav plasma concentration los ntawm 2-4 zaug. Lub purulent tso pa tawm ntawm lub bronchi yog qhov khoom tsis zoo. Thaum siv thaum cev xeeb tub, cov ntsiab lus ntawm amoxicillin hauv cov hlab ntsha ntawm txoj hlab ntaws thiab cov kua dej hauv lub cev yog 25-30% ntawm cov ntsiab lus hauv cov ntshav ntawm tus poj niam lub cev.

Nrog rau niam lub mis, ib qho me me yog tawm los. Cov ntshav-lub hlwb thaiv cov nyom yog qhov tsis zoo, qhov kev tsocai nyob rau ntawm cov kua dej cerebrospinal thaum siv amoxicillin rau kev kho mob rau daim npluag qhwv (mob rau daim npluag qhwv) tsis pub tshaj 20%.

Kev khi rau cov ntshav plasma protein - 17%.

Nws yog cov tshuaj nyob rau hauv cov ntim tsis tiav nrog kev tsim cov khoom siv tsis muaj zog.

Ib nrab-lub neej (T_1/2) yog 1-1.5 teev. 50-70% yog tawm los ntawm lub raum tsis hloov. Ntawm cov no, los ntawm kev txhaws glomerular - 20%, tubular excretion - 80%. 10-20% yog tawm los ntawm txoj hnyuv.

T_1/2 yog tias qhov tsis zoo lub raum muaj nuj nqi nrog creatinine tshem tawm (CC) ntawm 15 ml / min lossis tsawg dua, nws nce rau 8,5 teev.

Nrog hemodialysis, amoxicillin tawm.

Kev ntsuas rau siv

Raws li cov lus qhia, Amoxicillin yog qhia rau kev kho mob kis thiab kis mob los ntawm cov kab mob ua tau:

mob ntsws ua pa - mob ntsws, ua rau mob ntsws, mob ntsws txhaws ntswg, mob ntsws, ntsws mob ntsws,
kev kis mob ntawm ENT plab hnyuv siab raum - sinusitis, tonsillitis, pharyngitis, mob otitis,
kev kis mob ntawm cov tawv nqaij thiab cov nqaij mos - qhov thib ob mob dermatoses, erysipelas, impetigo,
kis kab mob ntawm cov kab mob genitourinary - cystitis, pyelonephritis, urethritis, kab mob gonorrhea,
cov kab mob gynecological - endometritis, mob ncauj tsev menyuam,
mob hnyuv - typhoid fever, paratyphoid fever, shigellosis (mob plab), salmonellosis, salmonella carriage,
peptic rwj ntawm lub plab thiab duodenum (raws li ib feem ntawm kev sib xyaw ua ke),
mob plab - enterocolitis, mob peritonitis, cholecystitis, cholangitis,
mob meningococcal,
listeriosis (mob voos thiab mob latent),
leptospirosis,
Borreliosis (Mob Lyme)
sepsis
endocarditis (kev tiv thaiv thaum kho hniav thiab lwm yam kev phais mob me).

Cov Yuav Tsum Muaj

daim siab ua hauj lwm
bronchial hawb pob,
quav nyab ua npaws
lymphocytic leukemia
mononucleosis mob sib kis,
mob raws plab vim yog noj tshuaj tua kab mob (nrog rau keeb kwm kho mob),
pub niam mis
ua kom txo tau cov tshuaj tua kab mob beta-lactam, suav nrog rau penicillins, cephalosporins, carbapenems,
kev tsis qaug rau lub zog ntawm cov tshuaj.

Cov tshuaj tiv thaiv ntxiv rau qee hom amoxicillin:

ntsiav tshuaj: kab mob ua xua (nrog rau keeb kwm kev kho mob), muaj hnub nyoog txog 10 xyoo nrog lub cev hnyav dua 40 kg,
tsiav tshuaj: atopic dermatitis, keeb kwm ntawm lub plab zom mov, hnub nyoog txog 5 xyoos,
granules: cov ntshav qabzib-galactose malabsorption syndrome, sucrose deficiency (isomaltase), fructose tsis nkag siab, mob dopatitis atopic, keeb kwm mob plab hnyuv.

Nrog kev ceev faj, nws raug pom zoo tias Amoxicillin raug kho rau cov neeg mob raum tsis ua haujlwm, keeb kwm los ntshav, nquag muaj kev txhim kho kev tsis haum (suav nrog keeb kwm), thaum cev xeeb tub.

Tsis tas li ntawd, ceev faj yuav tsum tau siv thaum siv cov ntsiav tshuaj rau kev kho mob ntawm cov neeg mob uas muaj keeb kwm ntawm lub plab zom mov.

Sab sij huam

los ntawm kev mob plab zom mov: ua txhaum ntawm kev nkag siab saj, xeev siab, ntuav, dysbiosis, raws plab, mob plab, pseudomembranous colitis, glossitis, lub siab ua haujlwm tsis zoo, nce kev ua haujlwm ntawm mob ntshav siab me ntsis, cholestatic jaundice, mob siab cytolytic,
los ntawm cov leeg hlwb: insomnia, ntxhov siab, mob taub hau, ntxhov siab vim, tsis meej pem, kiv taub hau, ataxia, hloov cwj pwm, mob peripheral neuropathy, kev nyuaj siab, kev txhaum,
kev tsis haum tshuaj: kub taub hau, urticaria, kais ntawm daim tawv nqaij, rhinitis, conjunctivitis, erythema, eosinophilia, angioneurotic edema, mob nyob rau hauv cov pob qij txha, exfoliative dermatitis, Stevens - Johnson poliformnaya (multiforme) erythema, allergic vasculitis, anaphylactic poob siab tshua zoo xws li cov ntshiab ntshav mob
kev kuaj ntsuas: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenic purpura,
los ntawm cov kab mob urinary: crystalluria, interstitial nephritis,
lwm tus: tachycardia, ua tsis taus pa, qhov ncauj ntawm lub plab, mob superinfection (ntau dua hauv kev kho tus mob mus ntev lossis hauv cov neeg mob uas lub cev txo qis).

Ntxiv mus, nws muaj peev xwm tsim cov kev mob tshwm sim hauv qab no uas tau qhia tawm thaum noj qee yam ntawm Amoxicillin:

ntsiav tshuaj: kev tsis haum tshuaj nyob rau hauv daim ntawv ntawm daim tawv nqaij ua pob, khaus, lom epidermal necrolysis, dav dav exanthematous pustulosis, mob hepatic cholestasis, eosinophilia,
tsiav tshuaj: lub qhov ncauj qhuav, cov plaub hau dub nplaig, candidiasis ntawm daim tawv nqaij thiab cov qog ua kua, nce ntxiv ntawm lub sijhawm prothrombin thiab lub sijhawm coagulation ntshav, staining ntawm txha hniav laus hauv daj, xim av lossis txho,
granules: “cov plaub hau dub” tus nplaig, tshem tawm hniav txha hniav laus, mob ntshav qab zib mob ntshav qab zib, mob ntshav txha hniav laus.

Cov lus qhia tshwj xeeb

Kev teem sijhawm ntawm Amoxicillin yog ua tau tsuas yog tias tsis muaj qhov qhia tseeb hauv keeb kwm kev mob ntawm tus neeg mob ntawm kev tsis haum tshuaj rau cov tshuaj tua kab mob beta-lactam (suav nrog rau penicillins, cephalosporins). Rau lub hom phiaj prophylactic, kev tswj hwm tib lub sij hawm ntawm antihistamines tau qhia.

Thaum siv cov tshuaj estrogen-hauv qhov ncauj txwv kom tsis txhob muaj menyuam yaus, cov pojniam yuav tsum tau qhia ntxiv rau kev siv txoj hauv kev tiv thaiv kom tsis txhob muaj menyuam thaum kho nrog amoxicillin.

Nrog rau kev kho tus mob tsis nco qab, kev txiav txim siab yuav tsum tau muab rau kev txo qis hauv lawv cov koob tshuaj.

Kev siv cov tshuaj tiv thaiv kab mob ua rau tsis muaj txiaj ntsig rau kev kho mob ntawm txoj kev tiv thaiv ua pa nyhav.

Amoxicillin yuav tsum tsis txhob raug tshuaj rau kev kho mob ntawm mononucleosis vim kev pheej hmoo ntawm kev txhim kho erythematous tawv nqaij ua pob thiab ua rau cov tsos mob ntawm tus kab mob.

Nws tsis pom zoo kom siv cov tshuaj amoxicillin rau kev kho mob ntawm cov neeg mob uas muaj kab mob ntawm txoj hnyuv, uas nrog los ntawm kev zawv plab los yog ntuav tas mus li.

Yog tias mob raws plab me thaum lub sijhawm noj cov tshuaj amoxicillin, koj tuaj yeem siv cov tshuaj tiv thaiv kab mob uas muaj kaolin lossis attapulgite, zam kev siv tshuaj uas ua rau lub plab hnyuv qeeb.

Thaum muaj mob raws plab uas muaj kua, tso quav ua kua dej ntawm lub xim ntsuab thiab muaj ntxhiab tsw ntxhiab, nrog rau cov ntshav txaus nrog los ntawm ua npaws thiab mob plab heev, koj yuav tsum tau sab laj nrog kws kho mob sai. Cov tsos mob no tuaj yeem ua rau pom kev mob hnyav ntxiv rau kev siv tshuaj tua kab mob nyob rau hauv daim ntawv ntawm kev txhim kho ntawm txhaws txhaws nqaij hlav txhaws.

Cev xeeb tub thiab lactation

Thaum lub sijhawm cev xeeb tub, kev siv tshuaj Amoxicillin yog ua tau yog tias xav tias yuav kho tau zoo rau leej niam, raws li kws kho mob, tshaj li qhov yuav muaj kev hem thawj rau tus menyuam hauv plab.

Kev siv cov tshuaj thaum lub sijhawm lactation yog contraindicated. Yog tias nws tsim nyog yuav sau tshuaj amoxicillin, pub mis rau noj yuav tsum tsis ua ntxiv.

Nrog lub raum tsis ua haujlwm

Nrog kev ceev faj, Amoxicillin yuav tsum siv los kho cov neeg mob raum tsis ua haujlwm.

Cov koob tshuaj ib txwm siv rau cov ntsiav tshuaj thiab cov granules yog siv hauv cov neeg mob nrog CC ntau dua 40 ml / min, rau cov tshuaj ntsiav nrog CC ntau dua 30 ml / min.

Thaum raum tsis zoo, yuav tsum tau txhaj tshuaj. Nws yog tsim tawm rau hauv tus account CC los ntawm kev txo qis ib koob lossis nce ib ncua sijhawm ntawm koob tshuaj Amoxicillin.

Nrog rau CC 15 ml40 ml / min, cov koob tshuaj ib txwm raug sau tseg, tab sis lub sijhawm nruab nrab ntawm cov koob tshuaj tau nce mus rau 12 teev, nrog CC tsawg dua 10 ml / min, qhov tshuaj yuav tsum raug txo los ntawm 15 by50%.

Qhov tshuaj tiv thaiv ntau tshaj plaws ntawm Amoxicillin hauv anuria yog 2000 mg.

Yog tias muaj teeb meem lub raum khiav tsis zoo hauv cov menyuam nrog CC ntau dua 30 ml / min, tsis tas yuav tsum muab tshuaj rau kom kho. Nrog rau CC ntawm 10-30 ml / min, cov menyuam tau raug txiav txim li 2/3 ntawm kev siv ib txwm, nce ib ncua sijhawm ntawm cov koob tshuaj ntau txog 12 teev. Hauv cov menyuam yaus nrog CC tsawg dua 10 ml / min, qhov ntau zaus ntawm kev muab tshuaj yog 1 zaug nyob rau ib hnub, lossis lawv tau raug txiav txim 1/3 ntawm cov menyuam ib txwm muaj.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tib lub sijhawm amoxicillin:

ascorbic acid: ua rau muaj kev nce qib hauv kev nqus ntawm nqus tshuaj,
aminoglycosides, antacids, laxatives, glucosamine: pab kom qeeb thiab txo qhov nqus,
ethanol: txo qhov kev nqus ntawm amoxicillin,
digoxin: ua rau nws nqus,
probenecid, phenylbutazone, oxyphenbutazone, indomethacin, acetylsalicylic acid: ua rau muaj kev nce siab ntawm amoxicillin hauv cov ntshav ntshav, ua rau nws txo qis,
methotrexate: qhov kev pheej hmoo ntawm kev tsim cov tshuaj lom cuam tshuam ntawm methotrexate yog nce,
indico anticoagulants thiab tshuaj nyob rau hauv cov metabolism uas para-aminobenzoic acid yog tsim: tiv thaiv keeb kwm yav dhau los ntawm kev txo qis hauv cov synthesis ntawm vitamin K thiab prothrombin Performance index vim hais tias kev tsuj tawm ntawm plab hnyuv microflora los ntawm amoxicillin, qhov kev pheej hmoo ntawm kev tawg los ntshav ntau ntxiv,
allopurinol: ua rau muaj kev pheej hmoo ntawm kev tsim cov tawv nqaij ua xua,
qhov ncauj tawm: qhov rov ua kom cov tshuaj estrogens hauv cov hnyuv txo, uas ua rau muaj kev txo qis hauv cov txiaj ntsig ntawm kev txiav tawm,
cov tshuaj tua kab mob (cycloserine, vancomycin, aminoglycosides, cephalosporins, rifampicin): ua rau cov nyhuv synergistic antibacterial,
cov tshuaj bacteriostatic (sulfonamides, macrolides, lincosamides, chloramphenicol, tetracyclines): pab txhawb kom tsis muaj zog ntawm cov kab mob bactericidal ntawm amoxicillin,
metronidazole: cov tshuaj tiv thaiv ntawm amoxicillin ntau ntxiv.

Amoxicillin analogues yog: ntsiav tshuaj - Amoxicillin Sandoz, Ecobol, Flemoxin Solutab, Ospamox, tsiav tshuaj - Hiconcil, Amosin, Ampioks, Hikontsil, Ampicillin Trihydrate.