Cov tshuaj Lozap Ntxiv

Lub npe thoob ntiaj teb - Lozap ntxiv

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Zaj duab xis-coated ntsiav tshuaj lub teeb daj, oblong, nrog cov kab sib faib hauv ib nrab ntawm ob tog. Hauv 1 tab muaj: losartan poov tshuaj - 50 mg, hydrochlorothiazide - 12,5 mg.

Tshwjxeeb: mannitol - 89 mg, microcrystalline cellulose - 210 mg, croscarmellose sodium - 18 mg, povidone - 7 mg, magnesium stearate - 8 mg, hypromellose 2910/5 - 6.5 mg, macrogol 6000 - 0.8 mg, talcum hmoov - 1.9 mg, simethicone emulsion - 0.3 mg, zas xim Opaspray daj M-1-22801 - 0.5 mg (dej lim, titanium dioxide, ethanol denatured (cawv cawv BP: ethanol 99% thiab methanol 1%), hypromellose, zas Quinolin Daj (E104), zas Pounceau 4R (E124).

Daim ntawv tso tawm: 10 Pcs. - hlwv (1, 3 lossis 9 pcs.) lossis 14 pcs. - hlwv (2) - pob khoom los ntawm cardboard.

Cov chaw soj ntsuam thiab chaw muag tshuaj

Cov tshuaj pab pawg kho mob

Antihypertensive ua ke nrog tus neeg sawv cev (angiotensin II receptor blocker + diuretic)

Pharmacological kev txiav txim

Cov tshuaj antihypertensive. Tshwj xeeb angiotensin II receptor antagonist (subtype AT 1). Nws tsis inhibit kininase II, ib qho enzyme uas catalyzes hloov dua siab tshiab ntawm angiotensin I rau angiotensin II. Txo OPSS, ntshav concentration ntawm adrenaline thiab aldosterone, ntshav siab, ntshav siab hauv cov ntsws ntsig, txo qis tom qab, muaj cov nyhuv diuretic. Nws cuam tshuam nrog kev txhim kho myocardial hypertrophy, ua rau lub cev muaj zog ntau dua nyob rau hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm ntev. Losartan tsis inhibit ACE kininase II thiab, raws li, tsis tiv thaiv kev puas tsuaj ntawm bradykinin, yog li ntawd, cov kev mob tshwm sim cuam tshuam nrog bradykinin (piv txwv li, angioedema) muaj tsawg heev.

Hauv cov neeg mob uas mob ntshav tawm tsis muaj ntshav qab zib tsis muaj concomitant mob ntshav qab zib mellitus nrog proteinuria (ntau dua 2 g / hnub), kev siv cov tshuaj txo cov proteinuria ntau, kev tsis haum ntawm albumin thiab immunoglobulins G.

Stabilizes qib ntawm urea hauv ntshav ntshav. Nws tsis muaj dab tsi cuam tshuam rau cov zaub tsis zoo ntawm lub cev thiab tsis muaj qhov cuam tshuam lub sijhawm ntev ntawm kev saib xyuas ntawm norepinephrine hauv cov ntshav ntshav. Losartan nyob rau hauv ib koob tshuaj txog li 150 mg / hnub tsis cuam tshuam rau theem ntawm triglycerides, tag nrho cov roj (cholesterol) thiab HDL cholesterol hauv cov ntshav cov ntshav hauv cov neeg mob ntshav siab. Nyob rau tib lub sijhawm, losartan tsis cuam tshuam rau yoo ntshav cov ntshav.

Tom qab ib qho kev tswj hwm ntawm qhov ncauj, qhov kev tiv thaiv hypotensive (systolic thiab diastolic ntshav siab) nce mus txog qhov siab tshaj plaws tom qab 6 teev, tom qab ntawd maj mam txo qis hauv 24 teev.

Qhov siab tshaj plaws kev kho mob tshwm sim 3-6 lub lis piam tom qab pib siv tshuaj.

Cov Tshuaj Pharmacokinetics

Thaum noj, losartan tau zoo nqus, thiab nws yauv yuag yuag thaum lub sijhawm "thawj tso" los ntawm daim siab los ntawm carboxylation nrog kev koom tes ntawm cytochrome CYP2C9 isoenzyme nrog kev tsim cov nquag metabolite. Txheej txheem ntawm cov neeg nruab nrog cev ntawm losartan yog li ntawm 33%. Qhov siab tshaj plaws ntawm losartan thiab nws cov metabolite ua tiav nyob rau hauv cov ntshav cov ntshav tom qab kwv yees li 1 teev thiab 3-4 teev tom qab noj, feem. Noj tsis txhob cuam tshuam rau lub bioavailability ntawm losartan.

Ntau tshaj li 99% ntawm losartan thiab nws cov nquag metabolite khi rau cov ntshav muaj protein ntau, feem ntau yog nrog albumin. V d losartan - 34 l. Losartan suab tsis nkag ntawm BBB.

Kwv yees li 14% ntawm losartan muab tso rau qhov ncauj lossis qhov ncauj tau hloov mus rau hauv ib qho tshuaj metabolite.

Lub plasma tshem ntawm losartan yog 600 ml / min, thiab cov nquag metabolite yog 50 ml / min. Lub raum tshem tawm ntawm losartan thiab nws cov metabolite yog 74 ml / min thiab 26 ml / min, feem. Thaum noj, kwv yees li 4% ntawm cov koob tshuaj noj tau tso tawm los ntawm lub raum tsis hloov pauv thiab kwv yees li 6% yog tawm los ntawm lub raum hauv daim ntawv ntawm cov tshuaj tiv thaiv metabolite. Losartan thiab nws cov tshuaj tiv thaiv kab mob nquag tau tshaj tawm yog cov tshuaj kws kho mob cov tshuaj thaum muab tshuaj rau qhov ncauj txog 200 mg.

Tom qab lub qhov ncauj tswj hwm, cov ntshav plasma ntau ntawm losartan thiab nws lub zog metabolite txo qis tshaj tawm nrog ib nrab hnub kawg ntawm lub neej ntawm losartan txog 2 teev, thiab ntawm lub cev metabolite txog li 6-9 teev. Thaum noj cov tshuaj ntawm 100 mg / hnub, tsis yog losartan los yog lub zog metabolite tseem ceeb hauv ntshav ntshav. Losartan thiab nws cov metabolites yog tawm ntawm cov hnyuv thiab lub raum. Hauv cov neeg tuaj yeem noj qab haus huv, tom qab noj cov losartan lo nrog 14 C-isotope, kwv yees li 35% ntawm daim paib hluav taws xob muaj nyob hauv cov zis thiab 58% hauv cov quav.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Hauv cov neeg mob uas mob sib khuav xws li cawv me ntsis txog rau kev haus dej cawv, lub siab ntawm losartan yog 5 zaug, thiab cov nquag metabolite yog 1.7 npaug ntau dua li cov txiv neej ua haujlwm pab dawb.

Nrog CC> 10 ml / min, qhov kev mloog ntawm losartan hauv cov ntshav ntshav tsis txawv ntawm qhov ntawd hauv lub raum kev ua haujlwm. Hauv cov neeg mob uas xav tau hemodialysis, AUC yog kwv yees li 2 npaug dua rau cov neeg mob uas lub raum tsis ua haujlwm.

Tsis yog losartan thiab nws lub zog metabolite tau tshem tawm ntawm lub cev los ntawm hemodialysis.

Qhov ntau ntawm losartan thiab nws cov metabolite hauv ntshav plasma hauv cov txiv neej laus uas mob ntshav tsis txawv ntau qhov tsis tseem ceeb ntawm cov txiaj ntsig ntawm cov txwv no hauv cov txiv neej hluas nrog kev mob ntshav siab.

Lub plasma cov ntsiab lus ntawm losartan nyob rau hauv cov poj niam uas mob arterial tawg yog 2 npaug ntau dua qhov tseem ceeb nyob rau hauv cov txiv neej nrog mob ntshav siab. Kev xav ntawm lub cev zom zaub mov nquag hauv txiv neej thiab poj niam tsis txawv. Qhov sib txawv ntawm pharmacokinetic no tsis yog qhov tseem ceeb hauv tsev kho mob.

• arterial hypertension (raws li ib feem ntawm kev sib txuas ua ke rau kev kho mob rau cov neeg mob uas kev kho mob zoo tshaj plaws),
• txo txoj kev pheej hmoo ntawm kev tsim kab mob plawv thiab kev tuag ntawm cov neeg mob ntshav siab thiab tawm pob txha tawg ventricular hypertrophy.

Cov Yuav Tsum Tau Ua

• kev kho mob hypokalemia los yog hypercalcemia,
• mob siab ua rau daim siab,
• obstructive kab mob ntawm biliary ib ntsuj av,
• lub zog ntsuas ntshav cev,
• hyperuricemia thiab / lossis gout,
• mob raum mob raum (CC ≤ 30 ml / min),
• anusia
• cev xeeb tub
• lub sij hawm pub niam mis,
• hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis tau tsim tsa),
• hypersensitivity rau ib qho twg ntawm cov tshuaj lossis lwm yam tshuaj uas yog derivatives ntawm sulfonylamide.

Nrog ceev faj kws kho mob rau cov neeg mob ob tog raum mob ntshav ntawm lub raum artery stenosis los ntawm tib lub raum artery, hypovolemic tej yam kev mob (suav nrog rau mob raws plab, ntuav), hyponatremia (muaj kev pheej hmoo ntawm txoj kev mob ntshav hauv cov neeg mob rau cov zaub mov muaj ntsev tsawg los yog ntsev tsawg), hypochloremic alkalosis, hypomagnesemia, nrog rau cov kab mob tiv thaiv cov nqaij mob (suav nrog SLE), cov neeg mob lub siab tsis ua hauj lwm lossis daim siab mob siab, ntshav qab zib mellitus, mob ntsws asthma (nrog rau keeb kwm), cov tshuaj tiv thaiv ua xua cal keeb kwm, ib txhij nrog narcotics yuav muab, nrog rau cov Cov pa roj carbon monoxide COX-2, nrog rau cov neeg sawv cev ntawm cov haiv neeg Negroid.

Dosage regimen thiab cov qauv ntawm daim ntawv thov Lozapa Ntxiv

Cov tshuaj tau noj ntawm qhov ncauj, tsis hais noj mov.

Ntawm leeg ntshav siab cov koob tshuaj uas ib txwm pib thiab txij nkawm yog 1 ntsiav tshuaj / hnub. Yog tias thaum siv cov tshuaj hauv cov tshuaj no, nws tsis tuaj yeem ua kom tiav cov ntshav siab txaus, qhov tshuaj ntawm cov tshuaj Lozap Plus tuaj yeem nce ntxiv rau 2 ntsiav tshuaj. 1 teev / hnub

Qhov siab tshaj plaws yog 2 ntsiav tshuaj. 1 teev / hnub Nyob rau hauv dav dav, qhov siab tshaj plaws hypotensive nyhuv tau tiav tsis pub dhau 3 lub lis piam tom qab pib ntawm kev kho mob.

Tsis tas yuav tsum muaj kev tshwj xeeb xaiv qhov pib txhaj tshuaj rau cov neeg laus laus.

Nrog los txo cov kev pheej hmoo ntawm kev tsim kab mob plawv thiab kev tuag ntawm cov neeg mob ntshav siab thiab sab laug ventricular hypertrophy losartan (Lozap) yog tus kws kho mob pib siv li 50 mg / hnub. Cov neeg mob uas tsis ua tiav cov phiaj xwm ntawm cov ntshav siab thaum siv losartan ntawm koob tshuaj 50 mg / hnub xav tau kev kho mob nrog kev sib xyaw ntawm losartan thiab hydrochlorothiazide nyob rau hauv koob tshuaj tsawg (12.5 mg), uas tau xyuas meej los ntawm kev teem sijhawm ntawm cov tshuaj Lozap Ntxiv. Yog tias tsim nyog, cov koob tshuaj ntawm Lozap Plus tuaj yeem nce ntxiv rau 2 ntsiav tshuaj. (100 mg ntawm losartan thiab 25 mg ntawm hydrochlorothiazide) 1 zaug / hnub.

Sab sij huam Lozapa Ntxiv

Cov kev phiv tsis zoo tau muab faib raws li qhov muaj ntau zaus ntawm kev txhim kho raws li hauv qab no: ntau heev (≥ 1/10), nquag (≥ 1/100 thiab mus txog

Vim li cas EMIS kev soj ntsuam ua rau kev muaj menyuam hauv plab?

Galvanized pleurisy ntawm lub ntsws cov tsos mob thiab kho - nyeem tag nrho cov ntaub ntawv hais txog mob qog nqaij hlav nyob rau hauv lub vev xaib ntawm European Clinic.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Lozap Plus muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab-cov ntsiav tshuaj: oblong, nrog kev pheej hmoo ntawm ob sab, lub teeb daj (10 pcs. Hauv cov hlwv, hauv pob ntawv qhwv ntawm 1, 3 lossis 9 hlwv, 14 pcs. Hauv cov hlwv, hauv cardboard ib ntim ntawm 2 lub hlwv).

Muaj pes tsawg leeg ib 1 ntsiav tshuaj:

• cov tshuaj nquag: hydrochlorothiazide - 12.5 mg, losartan potassium - 50 mg,
• Cov khoom siv ntu: microcrystalline cellulose, povidone, mannitol, magnesium stearate, croscarmellose sodium,
• zaj duab xis txheej: macrogol 6000, simethicone emulsion, crimson zas Ponso 4R, hypromellose 2910/5, talc, titanium dioxide, quinoline daj zas.

Cov Tshuaj Hauv Tshuaj

Lozap ntxiv yog qhov sib xyaw ua ke uas muaj qhov ua kom hypotensive. Losartan yog ib qho tshuaj angiotensin II receptor blocker, thiab hydrochlorothiazide yog thiazide diuretic.

Cov tshuaj ua ke ntawm cov tshuaj nthuav tawm cov txiaj ntsig synergistic, txo cov ntshav siab rau kev sib xyaw ua ke kom ntau dua li qhov tsis sib thooj.

Losartan txo qis OPSS (tag nrho peripheral vascular tsis kam), txo qis ntawm aldosterone thiab adrenaline nyob rau hauv cov ntshav, txo qhov siab nyob rau hauv cov hlab ntsws, ua kom muaj cov nyhuv diuretic thiab txo qis tom qab. Hauv cov neeg mob uas muaj lub plawv tsis ua hauj lwm ntev, losartan nce ntxiv rau kev ua kom lub cev, tiv thaiv qhov tshwm sim ntawm hypertrophy ntawm cov leeg plawv.

Hydrochlorothiazide ua kom zoo dua ntxiv ntawm kev tso zis ntawm phosphates, bicarbonate thiab potassium ions, txo qhov reabsorption ntawm sodium ions. Txo cov ntshav siab yog ua tiav los ntawm kev hloov pauv ntawm cov vascular phab ntsa, txo qhov ntim ntawm cov ntshav ncig, nce cov kev cuam tshuam ntawm kev cuam tshuam ntawm ganglia thiab txo cov nyhuv pressor ntawm vasoconstrictor tshuaj.

Cov nyhuv antihypertensive ntawm Lozap ntxiv txuas ntxiv tau 24 teev. Kev noj tshuaj tsis muaj qhov cuam tshuam tseem ceeb rau lub plawv dhia. Cov tshuaj zoo txo ​​cov ntshav siab rau cov txiv neej thiab poj niam, hauv cov neeg laus thiab cov hluas, cov neeg mob Negroid thiab lwm haiv neeg ntxiv, nrog rau txhua qhov kev mob ntawm cov ntshav siab.

Cov Tshuaj Pharmacokinetics

Losartan yog nrawm nrawm los ntawm lub plab zom mov. Nws txoj kev noj qab haus huv yog kwv yees li 33% vim los ntawm cov txiaj ntsig ntawm thawj kab hla mus rau daim siab. Kev mob plab tshwm sim los ntawm carboxylation, uas ua rau muaj qhov tsim cov khoom noj rau lub cev (metabolite) - carboxylic acid. 99% losartan khi rau cov plasma protein. Nws qhov siab tshaj plaws hauv plasma tau mus txog tom qab 1 teev, thiab qhov siab ntawm lub zog metabolite tom qab 3-4 teev. Noj mov tsis cuam tshuam loj heev cov ntshav plasma concentration ntawm losartan. Qhov ntim ntawm kev faib tawm yog 34 litres. Losartan kev siv tsis nkag rau cov ntshav-hlwb teeb meem. Ib nrab-lub neej ntawm losartan yog 1.5-2 teev, carboxylic acid yog 3-4 teev. Kwv yees li 35% ntawm cov koob tshuaj uas tau noj yog tso zis thiab txog 60% hauv kev mob quav.

Qhov nqus ntawm hydrochlorothiazide kuj tseem nrawm, nws tsis yog metabolized los ntawm daim siab. Hydrochlorothiazide tsis dhau los ntawm cov ntshav-lub hlwb teeb meem thiab tsis pub leejtwg paub los ntawm niam mis, tab sis nkag mus rau hauv qhov kev tiv thaiv placental. Qhov kev tshem tawm ib nrab-lub neej yog 5.8-14.8 teev. Kwv yees li 61% ntawm hydrochlorothiazide yog cov tsis hloov pauv los ntawm lub raum.

Cov chaw muag tshuaj tsis haum ntawm Lozap ntxiv nyob rau cov neeg laus laus tsis txawv ntau ntawm cov neeg mob hauv cov hluas.

Nrog cov ntshav cawv me los sis mob hnyav cawv ntawm lub siab, ntshav plasma concentration ntawm losartan thiab nws cov metabolite yog 5 thiab 1.7 zaus siab dua, feem ntau, ntau dua li cov neeg ua haujlwm noj qab haus huv. Hemodialysis yuav tsis zoo.

Cov Yuav Tsum Muaj

• mob siab ua rau daim siab,
• mob raum tsis ua haujlwm zoo (creatinine tshem tawm tsawg dua 30 ml / min),
• mob cholestatic syndrome
• inflammatory obstructive kab mob ntawm biliary ib ntsuj av,
• tsis muaj zis nyob rau hauv lub zais zis (anuria),
• hypercalcemia lossis hypokalemia (tiv taus kev kho mob),
• gout thiab / lossis cov tsos mob hyperuricemia,
• lub zog ntsuas ntshav cev,
• cev xeeb tub thiab lactation,
• cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo,
• sib koom tes tswj hwm nrog aliskiren hauv cov neeg mob raum tsis ua haujlwm (creatinine tshem tawm tsawg dua 60 ml / min) thiab ntshav qab zib mellitus,
• hypersensitivity rau lub ntsiab los yog txhawb cov tshuaj ntawm cov tshuaj.

Tus txheeb ze (Lozap ntxiv yog siv nrog ceev faj):

• hypovolemia (suav nrog ntuav lossis raws plab),
• kev mob hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypokalemia,
• hyperkalemia
• mob plawv plawv
• mob plawv tsis ua hauj lwm ntev,
• lub plawv tsis ua hauj lwm, nrog mob raum tsis zoo,
• lub plawv tsis ua hauj lwm nrog lub neej tsis xwm yeem,
• mitral lossis aortic stenosis,
• hypertrophic obstructive cardiomyopathy,
• lub siab ua tsis taus haujlwm,
• mob siab mob siab,
• ob leeg los sis ob tog (ib qho raum) mob raum leeg txoj hlab ntshav siab,
• mob tom qab lub raum hloov,
• mob ntsws asthma (nrog rau keeb kwm),
• mob cov ntaub so ntswg mob
• thawj hyperaldosteronism,
• keeb kwm ntawm Quincke tus edema,
• keeb kwm kev tsis haum,
• kab mob cerebrovascular,
• mob mob taub hau ntawm lub kaum sab xis ntsej muag daj thiab myopia,
• tib lub sij hawm siv nrog cov tshuaj uas tsis yog tshuaj steroidal,
• teej tug rau cov haiv neeg dub,
• lub hnub nyoog laus dua 75 xyoo.

Lozap ntxiv, cov lus qhia rau kev siv (hom thiab qhov ntau npaum li cas)

Lozap ntxiv rau cov ntsiav tshuaj tau noj ntawm qhov ncauj, tsis hais cov pluas noj dabtsi.

Hauv cov neeg mob uas mob ntshav liab, cov tshuaj tau sau tseg hauv thawj zaug thiab txij nkawm cov tshuaj 1 ntsiav tshuaj ib hnub. Yog tias cov koob tshuaj tau qhia tsis txaus los txo qhov ntshav siab txaus, nws muaj peev xwm nce ntxiv qhov koob tshuaj rau 2 ntsiav tshuaj ib hnub ib zaug.

Qhov siab tshaj plaws niaj hnub noj tshuaj yog 2 ntsiav tshuaj, thiab cov txiaj ntsig siab tshaj plaws tau tiav hauv 3 lub lis piam tom qab pib kho.

Rau cov neeg mob laus, Lozap ntxiv yog tus kws kho mob ib txwm pib muab.

Txhawm rau txo qis kev pheej hmoo ntawm cov kab mob plawv thiab kev tuag, thawj koob tshuaj losartan yog 50 mg ib hnub ib zaug (1 ntsiav tshuaj ntawm Lozap). Yog tias kev kho mob ua tsis muaj txiaj ntsig, nws yog qhov tsim nyog los xaiv txoj kev kho los ntawm kev sib txuas nrog losartan nrog cov koob tshuaj hydrochlorothiazide tsawg kawg (1 ntsiav tshuaj ntawm Lozap + 1 ntsiav tshuaj ntawm cov tshuaj Lozap ntxiv rau ib hnub). Yav tom ntej, nws yog qhov muaj peev xwm nce qhov ntau ntxiv rau 2 ntsiav tshuaj ntawm cov tshuaj Lozap ntxiv rau ib hnub ib zaug.

Sab sij huam

Kev phiv los sis cov tshuaj vim kev sib xyaw ntawm losartan + hydrochlorothiazide:

• daim siab thiab kab mob biliary: muaj tsawg - kab mob siab,
• hlab plawv mob: cov tsis paub - cov nyhuv orthostatic (koob tshuaj),
• cov leeg paj hlwb: tsis tshua muaj - kiv taub hau, zaus tsis paub - ua txhaum cai ntawm saj saj,
• daim tawv nqaij thiab cov nqaij mos ntawm daim tawv nqaij: ntau zaus tsis paub - cov kab mob lupus erythematosus (daim tawv nqaij),
• kev tshawb nrhiav thiab ntsuas: tsis tshua muaj - nce kev ua si ntawm daim siab enzymes, hyperkalemia.

Kev phiv los ntawm cov tshuaj Lozap ntxiv, vim yog cov ntsiab lus ntawm losartan hauv nws cov muaj pes tsawg leeg:

• lub plab zom mov, lub siab thiab lub plab: feem ntau - xeev siab, dyspeptic cuam tshuam, mob plab, tso quav, ua tsis taus pa - lub qhov ncauj qhuav, ntuav, mob hniav, mob plab, cem quav, plab, ntau zaus tsis paub - ua rau lub siab ua haujlwm tsis zoo,
• kev mob plawv rau lub cev: tsis ua haujlwm dhau los - orthostatic hypotension, angina pectoris, myocardial infarction, arrhythmias, txo ntshav siab, mob hauv pob tw, vasculitis, atrioventricular block II degree, palpitations,
• lymphatic system thiab ntshav: ua haujlwm tsis tu ncua - mob ntshav hauv daim tawv lossis hnoos qeev, ua haujlwm ntshav, erythrocytosis, tus kab mob Shenlein-Genoch, tsis paub ntau zaus - thrombocytopenia,
• cov kab mob ua pa: ntau - txhaws ntswg, hnoos, mob sinusitis, mob hlab pas sab saud, nthawv - laryngitis, mob ntsws, mob ntsws, mob ntsws, pharyngitis, dyspnea, txhaws ntswg,
• kev tsim kho lub siab thiab lub siab: feem ntau - kiv taub hau, pw tsaug zog, mob taub hau, ua tsis taus pa - ntxhov siab, pw tsaug zog, txob taus, ntxhov siab, txawv npau suav, tshee tshee, ceeb, tawm tsam, kev nyuaj siab, tsaug zog, kab ntsig, mob taub hau, nco ib ce, mob ib ce neuropathy, tsaus muag,
• cov khoom hauv lub cev: muaj qhov tsis pom tseeb - pom pob txha taub hau, qhov muag plooj, qhov muag pom tsis meej, hlawv qhov hnov ​​ntawm lub qhov muag, lub suab nrov hauv lub pob ntseg, mob siab,
• cov leeg ua haujlwm: feem ntau - mob mob ntawm txhais ceg thiab sab nraub qaum, sciatica, mob nqaij ntshiv, qoj ib ce - mob ntawm cov pob txha thiab cov leeg mob, mob caj dab, leeg tsis muaj zog, o ntawm cov pob qij txha, arthralgia, fibromyalgia, mob nruj ntawm cov pob qij txha, qhov zaus tsis paub - myoglobinuria nrog lub raum tsis ua haujlwm,
• cov kab mob ua haujlwm urinary: feem ntau - lub raum tsis ua haujlwm, lub raum lub raum kev ua haujlwm, kev tuaj yeem dhau mus - cov kab mob tso zis, tso zis ntau zaus, muaj ntau yam nyob rau hmo ntuj diuresis dhau ib hnub,
• kev muaj me nyuam: niaj hnub - erectile kawg, txo qis libido,
• daim tawv nqaij thiab nqaij mos ua kom tawv nqaij: qog ntxaws - dermatitis, erythema, duab tawv nqaij, tawv nqaij ua pob, plaub hau ploj, tawv qhuav, hyperemia, tawv nqaij khaus, tawm hws,
• kev tiv thaiv kab mob: tsis tshua muaj - Quincke's edema, kev ua kom tsis nco qab,
• cov metabolism thiab khoom noj khoom haus: qhaj ntawv - gout, anorexia,
• kev tshawb nrhiav thiab ntsuas: feem ntau - txo qis hauv hemoglobin thiab hematocrit, hyperkalemia, ua tsis tau zoo - nce me ntsis hauv plasma creatinine thiab urea, tsis tshua muaj tshwm sim - kev nce bilirubin thiab daim siab ua haujlwm enzyme, qhov ntau zaus tsis paub - tsawg zuj zus ntawm ntshav dej sodium concentration,
• lwm cov kev cuam tshuam: feem ntau - nkees, mob hauv siab, asthenia, tsis xws luag - kub taub hau, o ntawm lub ntsej muag, qhov ntau heev tsis paub - tsis muaj zog, cov tsos mob zoo li khaub thuas.

Kev phiv los ntawm cov tshuaj Lozap ntxiv, vim yog cov ntsiab lus ntawm hydrochlorothiazide hauv nws cov muaj pes tsawg leeg:

• lub plab zom mov, lub siab thiab lub plab: ua haujlwm dhau hwv - xeev siab, tu cev, ntuav, mob plab, mob rau lub raum, mob rau cov qaub ncaug qaub ncaug, cem quav lossis raws plab, cholecystitis, cholestatic jaundice,
• hlab plawv system: ua haujlwm dhau los - vasculitis (tawv nqaij lossis necrotic),
• lymphatic system thiab ntshav: ua haujlwm tsis tu ncua - ntshav liab (hemolytic lossis aplastic), agranulocytosis, thrombocytopenia, purpura, leukopenia,
• cov kab mob ua pa: ib ce - muaj pa nyuaj heev, nrog rau cov tsis muaj mob ntsig txog lub ntsws thiab mob ntsws,
• cov hlab ntsha hauv siab thiab kev zoo siab: feem ntau - mob taub hau, ua haujlwm dhau hwv - insomnia,
• cov kabmob hauv nruab nrog cev: ua haujlwm dhau los - pom cov khoom hauv daj, ib ntus qis hauv qhov pom pom,
• musculoskeletal system: ua haujlwm dhau los - cov leeg mob,
• cov kab mob zis: tso zis - lub raum tsis ua haujlwm, interstitial nephritis, muaj cov piam thaj hauv cov zis,
• daim tawv nqaij thiab nqaij tawv nqaij: ua haujlwm dhau los - ua pob ua pob ua pob, ua kom lub ntsej muag, mob ua paug, ua kom tawv nqaij ua kom tsis haum,
• kev tiv thaiv kab mob: tsis tshua muaj - ntau yam tshuaj tiv thaiv anaphylactic (qee zaus txog kev poob siab),
• cov metabolism thiab khoom noj khoom haus: qhaj ntawv - tsis nco qab,
• kev tshawb nrhiav thiab ntsuas: ua ntu zus - ib qho kev txo qis ntawm cov tshuaj sodium thiab potassium hauv cov ntshav dej, cov ntsiab lus ntau ntxiv ntawm uric acid hauv cov ntshav, hyperglycemia,
• lwm cov tshuaj tiv thaiv: tsis haum - kiv taub hau, ua npaws.

Noj ntau dhau

Nrog kev noj ntau dhau ntawm Lozap ntxiv, cov tsos mob hauv qab no tau pom: vim yog cov ntsiab lus ntawm losartan - bradycardia, tachycardia, txo qis ntshav siab vim cov ntsiab lus ntawm hydrochlorothiazide - poob ntawm electrolytes thiab lub cev qhuav dej.

Kev noj tshuaj ntau dhau yog mob. Nws yog ib qho tsim nyog kom tsum tsis txhob noj cov tshuaj, yaug lub plab thiab ntsuas kev tswj kom rov qab tau cov dej-electrolyte tshuav nyiaj li cas. Nrog kev txo qis hauv cov ntshav siab, txij nkawm Txoj kev lis ntshav kev kho mob yog qhia. Hemodialysis rau kev tshem tawm losartan yuav tsis ua haujlwm. Cov degree ntawm hydrochlorothiazide tshem tawm los ntawm hemodialysis tseem tsis tau tsim.

Cov lus qhia tshwj xeeb

Raws li cov lus qhia, Lozap Plus tuaj yeem siv ua ke nrog lwm cov tshuaj tiv thaiv kabmob.

Thaum kho, nws yog ib qho tsim nyog los tswj cov tsos ntawm cov tsos mob ntawm kev ua txhaum ntawm dej-electrolyte tshuav, kev loj hlob tiv thaiv keeb kwm ntawm concomitant ntuav lossis raws plab. Hauv cov neeg mob zoo li no, cov roj ntsha hluav taws xob yuav tsum tau saib xyuas tsis tseg.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Kev tshawb nrhiav tshwj xeeb ntawm kev ua haujlwm ntawm cov tshuaj Lozap ntxiv rau lub hlwb psychomotor peev xwm ntawm tib neeg tsis tau ua. Txawm li cas los xij, nws yuav tsum tau yug hauv siab tias thaum kho nrog cov tshuaj tiv thaiv kabmob, tshwj xeeb tshaj yog thaum pib kho, tsaug zog lossis kiv taub hau yuav tshwm sim, uas tuaj yeem cuam tshuam rau tus nqi tshuaj tiv thaiv thiab kev xav.

Cev xeeb tub thiab lactation

Cov tshuaj uas cuam tshuam ncaj qha rau renin-angiotensin system yog contraindicated rau siv nyob rau hauv zaum ob thiab thib peb lub cev xeeb tub hauv plab, vim tias lawv tuaj yeem ua rau tuag hauv plab. Thaum cev xeeb tub tshwm sim, Lozap ntxiv yuav tsum tau tsum tsis ua hauj lwm.

Kev teem sij hawm ntawm diuretics rau cov poj niam cev xeeb tub tsis pom zoo, vim tias nws muaj kev pheej hmoo siab mob daj ntseg hauv menyuam thiab menyuam mos, nrog rau thrombocytopenia hauv niam.

Lozap ntxiv yog contraindicated nyob rau hauv cov pojniam tsis haum, vim tias thiazides tuaj yeem ua rau cov diuresis khaus thiab inhibit mis ntau lawm.

Yeeb tshuaj sib cuam tshuam

Kev siv tib lub sijhawm ntawm Lozap ntxiv nrog rau cov tshuaj potassium-sparing diuretics, cov tshuaj uas muaj cov tshuaj potassium los yog cov tshuaj uas muaj cov tshuaj ntsev ntxiv rau cov tshuaj ntsev yog tsis pom zoo (kev nce qib hauv cov poov tshuaj hauv ntshav yog ua tau).

Losartan txhim kho kev kho mob cuam tshuam los ntawm lwm cov tshuaj kom txo cov ntshav siab. Tsis muaj kev siv tshuaj kho mob tseem ceeb ntawm losartan nrog cimetidine, ketoconazole, hydrochlorothiazide, phenobarbital, erythromycin, indirect anticoagulants thiab digoxin tau sau tseg.

Nrog tib lub sijhawm siv thiazide diuretics thiab qee yam tshuaj, kev sib cuam tshuam hauv qab no tuaj yeem pom:

• hypoglycemic tshuaj rau qhov ncauj tswj hwm thiab insulin - yuav tsum tau txhaj tshuaj kho cov peev nyiaj tau teev tseg,
• ethanol, narcotic analgesics, barbiturates - qhov pheej hmoo ntawm postural (orthostatic) hypotension tau nce,
• adrenocorticotropic lawm, corticosteroids - cov hluav taws xob tsis txaus, tshwj xeeb tshaj yog potassium, yog kho kom zoo dua
• lithium npaj - kev pheej hmoo ntawm lithium intoxication nce,
• colestyramine, colestipol - qhov nqus ntawm hydrochlorothiazide yog txo,
• tsis siv tshuaj tiv thaiv tsis haum tshuaj - nws muaj peev xwm txo cov diuretic, hypotensive thiab natriuretic cuam tshuam ntawm diuretics,
• pressor amines (adrenaline, thiab lwm yam) - txo qis hauv lawv cov nyhuv raug pom,
• tsis-depolarizing cov leeg ua si (tubocurarine chloride, thiab lwm yam) - nws yog qhov ua tau los txhim kho lawv cov kev ua,
• probenecid, allopurinol, sulfinpyrazone - tej zaum yuav tsum tau txhaj tshuaj kho cov tshuaj no,
• salicylates - nws yog ua tau los txhim kho cov tshuaj lom nyhuv ntawm salicylates ntawm lub hauv nruab nrab hauv lub paj hlwb,
• cytotoxic tshuaj - lawv cov nyhuv myelosuppressive kuj yuav ua kom zoo zog,
• cyclosporine - muaj cov nyom ntawm gout thiab ib qho kev pheej hmoo ntawm hyperuricemia,
• methyldopa - raug soj ntsuam cov neeg mob ntshav tsawg tsis zoo,
• anticholinergics - kev nce ntxiv hauv kev siv hluav taws xob hauv lub cev ntawm hydrochlorothiazide yog ua tau,
• lwm cov tshuaj tiv thaiv antihypertensive - ib qho txiaj ntsig zoo yuav raug pom.

Cov cim ntawm Lozapa ntxiv yog: Lozartan, Lozartan-N Canon, Lozartan-N Richter, Lorista, Lorista N, Lorista N 100, Lakea, Lozarel, Cozaar, Centor, Presartan.

Kev txheeb xyuas ntawm Lozap Plus

Raws li kev txheeb xyuas, Lozap Plus yog cov tshuaj zoo rau txo cov ntshav siab. Cov neeg mob nco ntsoov tias nws tsis tsuas yog pab ua kom zoo mob ntshav siab, tab sis kuj tiv thaiv kev txhim kho ntawm qee cov kab mob plawv. Lozap ntxiv nrawm txo lub siab thiab muaj txiaj ntsig thaum nruab hnub. Ntawm qhov zoo ntawm cov tshuaj, nws txoj kev cia siab, siv tau yooj yim (ib hnub ib zaug), cov nyhuv me thiab kev nyab xeeb tau sau tseg.

Qhov tsis zoo ntawm cov tshuaj hauv qee qhov kev txheeb xyuas suav nrog phiv uas Lozap ntxiv tuaj yeem ua rau, thiab qhov tseeb tias cov tshuaj muaj txiaj ntsig tsuas yog siv tas li. Qee tus neeg mob yws ntawm nws tus nqi siab (nws yog qhov muaj txiaj ntsig ntau dua los yuav cov tshuaj hauv cov pob loj).

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Cov tshuaj "Lozap ntxiv" nyob nrog pawg ntawm cov tshuaj tiv thaiv kabmob. Sab nraud, cov no yog ntsiav tshuaj ntawm daj lossis yuav luag dawb xim, oblong duab. Zaj duab xis yuav siv lub tshuaj. Muaj txaij ntawm ob sab ntawm cov ntsiav tshuaj. Hauv cov hlwv qhwv ntawm 10 lossis 15 ntsiav tshuaj, ntim hauv pob ntawv los qhia. Lozap ntsiav tshuaj muaj 2 cov khoom xyaw nquag - poov tshuaj losartan thiab hydrochlorothiazide. Lawv cov ntsiav tshuaj muaj 50 mg thiab 12.5 mg, ntsig txog. Ntu Cheebtsam yog:

Cov lus qhia rau kev teem caij

Cov lus qhia rau kev siv hais tias "Lozap Plus" tuaj yeem siv los ua cov tshuaj cais hauv kev kho mob lossis ua ib qho txuas rau kev kho txoj kev kho mob. Ua ntej siv, sab laj nrog koj tus kws kho mob. Nws tsim nyog pom tias "Lozap" thiab "Lozap plus" muaj qhov yuav luag zoo ib yam los ntawm kev coj thiab kev kho. Kev qhia rau kev siv yog:

• qhov nce siab hauv cov ntshav siab ntawm qhov tsis tu ncua lossis ntu ntu,
• raws li ib feem ntawm kev kho mob hauv kev kho mob ntawm kev mob plawv tsis zoo,
• raws li kev tiv thaiv kab mob ntawm cov kab mob plawv,
• nrog rau kev nthuav qhia ntshav qab zib nrog kub siab.

Cov lus qhia rau kev siv thiab ntau npaum li cas ntawm cov tshuaj "Lozap ntxiv"

Cov txheej txheem ntawm kev thov thiab kev siv tshuaj pom zoo yog dab tsi sib txawv Lozap los ntawm Lozap Plus. Nws yog qhov tseeb haus 1 ntsiav tshuaj (50 mg ntawm losartan) ib hnub. Tsis muaj kev txuas rau hauv cov khoom noj. Yog tias dhau sijhawm dhau los, lub siab tsis poob ntau npaum li cov neeg xav tau, cov tshuaj yuav tsum nce ntxiv. Nws zoo dua tsis txhob noj ntau dua 2 ntsiav tshuaj ib hnub. Qhov no yog fraught nrog kev noj qab haus huv txim. Txhawm rau tiv thaiv kab mob plawv, nws txaus los noj 1 ntsiav tshuaj ib hnub. Yog tias tus kws kho mob sau ntawv Lozap 100, ib nrab ntsiav tshuaj ib hnub (50 mg) yog qhov txaus. Ua ntej pib kev kho mob, koj yuav tsum sab laj nrog tus kws kho mob thiab tau kuaj mob.

Tshuaj zoo sib xws

Cov tshuaj "Lozap Plus" yog tshuaj los ntawm cov kws kho mob ua ntxiv rau txoj kev kho mob tseem ceeb. nws yog ib qho tseem ceeb uas yuav tsum xav txog kev sib xyaw thiab kev cuam tshuam ntawm cov khoom siv nquag. Cov chaw tsim khoom lag luam qhia qhov cuam tshuam ntawm losartan rau lwm cov tshuaj nyob hauv qhov chaw cim. Nrog rau kev tswj hwm tib lub sij hawm nrog cov tshuaj antihypertensive, lub siab poob sai dua. Tshaj cov poov tshuaj ntau yog pom thaum ua ke nrog cov kab mob potassium. Kev txo qis hauv cov nyhuv yog pom thaum ua ke nrog cov tshuaj tsis-steroidal los tiv thaiv. Kev ywj pheej pib ntawm kev siv ntau yam tshuaj tib lub sijhawm yog txwv tsis pub.

Cev xeeb tub thiab lactation

"Lozap Plus" lossis "Lozap" thaum cev xeeb tub yog txwv tsis pub. Qhov no yog qhov tseeb tshwj xeeb tshaj yog rau cov poj niam npaj cev xeeb tub thiab thawj peb lub hlis ntawm kev xeeb tub. Qhov no yog vim qhov tsis zoo ntawm cov tshuaj ntawm cov muaj pes tsawg leeg ntawm tus me nyuam hauv plab. Losartan tuaj yeem dhau mus rau niam mis. Vim li no, kev pub mis yuav tsum tsis ua ntxiv thaum kho. Koj tuaj yeem xa tus me nyuam mus rau kev pub mis ntuj tom qab 2 hnub tom qab txhaj koob tshuaj kawg.

Cov menyuam yaus thiab hnub nyoog laus

Muaj hnub nyoog txog 18 xyoo txwv tsis pub noj "Lozap Plus". Cov chaw tsim khoom ceeb toom ntawm qhov kev phom sij ntawm kev nkag mus. Rau cov neeg mob laus, cov tshuaj pib yog 50 mg ib hnub twg. Hauv qhov no, koj yuav tsum tau soj ntsuam koj txoj kev noj qab haus huv tas mus li thiab sim kev sim ntsuas. Yog tias tsis muaj kev cuam tshuam, cov tshuaj yuav tsum tau hloov mus rau cov tshuaj zoo sib xws lossis sib thooj.

Rau teeb meem raum thiab mob siab

"Lozap plus" yog siv nrog kev ceev faj thaum muaj kev ua haujlwm ntawm daim siab ua haujlwm tsawg dua 9 ntawm qib ntawm Child-Pugh. Qhov koob tshuaj tsis yog ntau dua 1 ntsiav tshuaj hauv ib hnub. Nrog txoj kev loj hlob ntawm daim siab ua haujlwm, daim siab txais tos yog txwv tsis pub. Kev tsis sib haum xeeb hauv kev ua haujlwm ntawm cov kabmob ntawm cov genitourinary system yuav tsum tau ua tib zoo xaiv cov koob tshuaj thiab lub sijhawm kho. Tseem ceeb yog txoj kev kuaj cov zis.

Kev kho zoo sib xws

Yog tias muaj cov tshuaj contraindications rau cov tshuaj "Lozap Plus" lossis yog tias nws tsis muaj nws hauv cov tsev muag tshuaj, koj yuav tsum xaiv tus hloov pauv. Hauv qhov no, lub cuab yeej yuav tsum zoo sib xws rau hauv thawj, thaum ua tiav tag rau tus neeg mob. Qhov kev xaiv yog nqa los ntawm tus kws kho mob mus koom nrog hauv tus account tus neeg mob lub keeb kwm kho mob. Cov kev hloov pauv tau yog Cardomin, Co-Centor, Losartan, Lorista, Nostasartan, Logzartik Plus, Kandekor thiab Valsartan.

Kev ntsuas rau siv

Lozap Plus pom zoo kom siv los ua ib feem ntawm txoj kev kho mob ntsig txog kev mob ntshav siab rau cov neeg mob uas tau kho cov kev kho no. Cov tshuaj tseem yog coj mus rau kev mob ntshav txhaws thiab sab laug ventricular hypertrophy kom txo qis kev pheej hmoo ntawm kev txhim kho cov hlab plawv pathologies thiab kev tuag.

Cov lus qhia rau kev siv Lozap Ntxiv: txoj kev thiab qhov ntau npaum li cas

Lozap Plus ntsiav tshuaj tau noj ntawm qhov ncauj, tsis hais lub sijhawm noj mov.

Cov tshuaj pom zoo raws li cov cim:

• arterial hypertension: pib thiab txij nkawm qhov koob tshuaj - 1 ntsiav tshuaj ib hnub, hauv qhov tsis ua tiav kev tswj ntshav siab, qhov koob tshuaj yuav raug nce mus txog qhov siab kawg 2 ntsiav tshuaj 1 zaug hauv ib hnub, qhov siab tshaj plaws hypotensive nyhuv ntawm cov tshuaj tau tiav tsis pub dhau 3 lub lis piam los ntawm kev pib kho,
• kev txo qis hauv kev pheej hmoo ntawm cov hlab plawv pathologies thiab kev tuag ntawm cov neeg mob ntshav siab thiab ntshav tawm ntawm lub plawv tawg: qhov pib ntawm losartan yog 50 mg / hnub, nyob rau hauv qhov tsis muaj kev tswj txaus thiab lub hom phiaj ntshav siab nrog losartan monotherapy, kev sib xyaw ntawm losartan nrog hydrochlorothiazide nyob rau hauv ib koob tshuaj tsawg tsawg yuav tsum tau ( 12,5 mg), uas tau ua kom ntseeg tau los ntawm kev siv cov tshuaj Lozap Plus, yog tias tsim nyog, qhov koob tshuaj tuaj yeem raug ntxiv rau 2 ntsiav tshuaj 1 zaug hauv ib hnub (100 mg ntawm losartan + 25 mg ntawm hydrochlorothiazide).

Nrog lub siab ua haujlwm tsis zoo

Raws li kev tshawb fawb pharmacokinetic nyob rau hauv cov neeg mob uas muaj kab mob siab, ib qho cim nce hauv plasma ntau ntawm losartan yog pom. Thiazide diuretics, suav nrog hydrochlorothiazide, tuaj yeem ua rau mob cholestasis intrahepatic, thiab kev cuam tshuam me me hauv dej-electrolyte tshuav nyiaj tuaj yeem ua rau muaj kev txhim kho mob hepatic coma. Hauv qhov kev sib txuas no, Lozap Plus yog tus muaj kev ceev faj yog tias muaj teeb meem ntawm daim siab ua haujlwm (suav nrog keeb kwm) lossis mob siab ua daim siab. Nyob rau hauv kev ua txhaum loj ntawm daim siab ua haujlwm, kev siv cov tshuaj yog contraindicated.

Hydrochlorothiazide

• barbiturates, haus cawv, opioid analgesics, tshuaj tiv thaiv kev ntxhov siab: kev pheej hmoo ntawm orthostatic hypotension nce,
• cov tshuaj tiv thaiv kab mob (insulin thiab hypoglycemic cov neeg sawv cev rau qhov ncauj tswj hwm): hydrochlorothiazide muaj peev xwm cuam tshuam rau lawv qhov kev tso ntshav qabzib, uas yuav xav tau kev hloov kho koob tshuaj,
• metformin: kev txhim kho ntawm cov kab mob lactic acidosis tuaj yeem ua tiav, qhov tshwm sim ntawm kev ua haujlwm ntawm lub raum tsis ua haujlwm vim kev siv hydrochlorothiazide, kev ceev faj yuav tsum siv thaum siv ua ke,
• lwm cov tshuaj tiv thaiv kev tiv thaiv kabmob: kev sib txuas ntawm kev nqis tes ua los pab txhawb kev txhim kho cov nyhuv ntxiv,
• colestyramine, colestipol: ion-txauv resins inhibit qhov nqus ntawm hydrochlorothiazide, ib koob tshuaj colestyramine / colestipol ua rau qhov khi ntawm hydrochlorothiazide thiab txo nws nqus los ntawm txoj hnyuv huam li 85% / 43%,
• corticosteroids, adrenocorticotropic hormone (ACTH): tuaj yeem dhau qhov tsis muaj cov electrolytes, tshwj xeeb tshaj yog hypokalemia,
• pressor amines (adrenaline): tej zaum ib qho kev txiav txim tsawg, tsis suav nrog lawv siv,
• tsis-depolarizing cov leeg ua kom mob (tubocurarine chloride): hydrochlorothiazide tuaj yeem txhim kho lawv cov nyhuv,
• kev npaj lithium: diuretics, suav nrog hydrochlorothiazide, txo qis kev kho lub raum, ua rau muaj kev phom sij ntawm cov roj ntsha lithium ntau dua, kev siv ib txhij pom zoo kom zam,
• cov tshuaj tiv thaiv gout (sulfinpyrazone, probenecid, allopurinol): kev kho kom haum yuav tsum tau siv, vim tias hydrochlorothiazide muaj peev xwm nce cov ntshiab uric acid ntau ntau, nws yuav ua rau kom muaj kev tshwm sim ntawm kev tsis haum rau allopurinol,
• cov tshuaj anticholinergic (atropine, biperidine): tuaj yeem nce lub bioavailability ntawm hydrochlorothiazide vim yog inhibition ntawm lub plab zom mov qoj ib ce thiab txo qis hauv tus nqi ntawm lub plab zom mov,
• cytotoxins (methotrexate, cyclophosphamide): nws yog qhov ua tau rau inhibit lawv qhov kev tso tawm los ntawm lub raum thiab txhim kho cov nyhuv myelosuppressive,
• salicylates: thaum siv nyob rau hauv cov koob tshuaj loj, lawv cov tshuaj lom rau lub zog hauv nruab nrab (CNS) yuav nce ntxiv
• methyldopa: raug cais tawm ntu kev tshwm sim ntawm kev txhim kho hemolytic anemia yog piav qhia,
• cyclosporine: muaj kev pheej hmoo ntawm hyperuricemia thiab mob hnyav ntawm gout,
• mob glycosides: hypokalemia / hypomagnesemia tshwm sim los ntawm hydrochlorothiazide tuaj yeem pab txhawb kev txhim kho digitalis hob arrhythmias,
• digitalis glycosides, tshuaj antiarrhythmic (cov nyhuv tshuaj uas ua raws qib ntshiab poov tshuaj), chav kawm IA antiarrhythmic tshuaj (hydroquinidine, quinidine, disopyramide), chav kawm III tshuaj tiv thaiv kab mob (amiodarone, dofetilide, ibutilide, sotalol), ib co tshuaj tiv thaiv kab mob (antipsychotics), thior , trifluoperazine, cyamemazine, sultopride, sulpiride, amisulpride, pimozide, tiapride, droperidol, haloperidol), lwm yam tshuaj uas tuaj yeem ua rau ventricular tachycardia ntawm pirouette yam (difemanil, bepridil, cisapride, erythromycin rau cov leeg, halofantrine, pentamidine, misolastine, terfenadine, vincamycin intravenously): nws tau pom zoo kom soj ntsuam cov poov tshuaj ntau ntau ntxiv, vim tias hypokalemia yog ib qho tseem ceeb rau kev txhim kho ntawm pyruet tachycardia, thiab tshuaj xyuas (tsim nyog) ECGcardog
• calcium ntsev: hydrochlorothiazide tuaj yeem nce qib hauv calcium nyob rau hauv cov ntshav vim qhov txo qis hauv nws txoj kev tsis txaus siab, nws yuav tsum tau soj ntsuam cov ntshiab calcium qib thiab kev txhim kho qhov tsim nyog ntawm cov tshuaj lim dej ntawm calcium npaj, vim cov nyhuv ntawm calcium metabolism, hydrochlorothiazide tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev ntsuas parathyroid kev ua haujlwm,
• carbamazepine: kev soj ntsuam kev soj ntsuam thiab kuaj ntsuas cov ntshav sodium hauv cov neeg mob uas siv cov carbamazepine yog qhov tsim nyog, vim muaj kev pheej hmoo ntawm kev tsim cov tsos mob hyponatremia,
• iodine-cov muaj teeb meem sib piv: nrog lub cev qhuav dej los ntawm diuretics, txoj kev pheej hmoo ntawm kev tsim muaj lub raum tsis ua haujlwm nce ntxiv, tshwj xeeb tshaj yog thaum noj tshuaj iodine nyob rau hauv cov koob tshuaj ntau, yog li yuav tsum tau lub cev dej ua ntej tswj hwm
• amphotericin B (parenteral), glucocorticosteroids, ACTH stimulant laxatives los yog glycyrrhizin (pom nyob rau hauv licorice): hydrochlorothiazide tuaj yeem ua rau electrolyte tsis txaus, tshwj xeeb tshaj yog hypokalemia.

Cov qauv ntawm Lozap Ntxiv yog: Gizaar, Gizaar Forte, Hydrochlorothiazide + Lozartan TAD, Blocktran GT, Lozarel Plus, Lozartan-N Canon, Lozartan N, Lozartan / Hydrochlorothiazide-Teva, Presartan N, Lorista N 100, Lorista N, Siman Nd.

Kev txheeb xyuas ntawm Lozap Plus

Cov neeg mob uas tau xaiv Lozap Plus los ua kom qis dua lawv lub siab tawm feem ntau yog tshuaj xyuas zoo. Lawv sau tias kev noj cov ntsiav tshuaj ib hnub ib zaug ua rau muaj kev noj qab haus huv zoo, ruaj khov txo qis, thiab tsis tuaj yeem kiv taub hau. Qee tus neeg txhawj xeeb txog kev coj tus cwj pwm noj tshuaj thiab txaus siab rau nws seb puas muaj kev phom sij nrog kev siv ntev.

Cov neeg mob uas muaj lub siab xav o tuaj yeem raug tso tseg Lozap Plus txoj kev kho, vim tias cov tshuaj diuretics yog sib kis thaum lub sijhawm tswj hwm, lossis lwm txoj hauv kev tswj hwm nrog cov kev kawm ntawm lwm cov tshuaj tiv thaiv kev tiv thaiv.

Lozap ntxiv: cov lus qhia rau kev siv (noj thiab hom)

Lozap ntxiv rau cov ntsiav tshuaj tau noj ntawm qhov ncauj, tsis hais lub sijhawm noj mov.

Qhov pom zoo pom zoo:

• arterial hypertension: koob tshuaj thawj zaug thiab txij nkawm - 1 ntsiav tshuaj ib hnub. Yog tias tsis muaj qhov tshwm sim hauv daim ntawv ntawm kev ua tiav ntawm cov ntshav siab txaus, cov koob tshuaj tuaj yeem nce ntxiv mus txog ntau kawg 2 ntsiav tshuaj ib hnub ib zaug. Qhov siab tshaj plaws ntawm kev tiv thaiv tau tiav hauv 3 lub lis piam tom qab pib kho,
• arterial hypertension thiab sab laug ventricular hypertrophy - txhawm rau txo qis kev pheej hmoo ntawm kev tsim cov hlab plawv thiab kev tuag: thawj koob tshuaj losartan yog 50 mg ib hnub ib zaug. Yog tias, tawm tsam cov keeb kwm yav dhau los ntawm kev kho mob monotherapy nrog losartan, nws tsis tuaj yeem ua kom tiav lub hom phiaj ntawm cov ntshav siab, nws yog qhov tsim nyog los xaiv txoj kev kho ua ke ntawm losartan nrog hydrochlorothiazide hauv koob tshuaj tsawg (12.5 mg). Yog tias tsim nyog, qhov koob tshuaj losartan tuaj yeem nce ntxiv txog 100 mg / hnub nyob rau hauv kev sib xyaw nrog hydrochlorothiazide ntawm koob tshuaj 12,5 mg / hnub. Yav tom ntej, nws yog qhov muaj peev xwm nce qhov koob ntau tshaj plaws - 2 ntsiav tshuaj Lozap ntxiv rau ib hnub ib zaug.

Nrog lub raum tsis ua haujlwm

Raws li cov lus qhia, Lozap ntxiv yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj ob sab mob raum leeg mob raum los yog lub raum leeg mob ntawm cov raum ib leeg, zoo li ntawm cov neeg mob uas nyuam qhuav hloov raum.

Muaj pov thawj ntawm kev txhim kho lub raum ua tsis tiav vim kev tiv thaiv ntawm losartan los ntawm renin-angiotensin-aldosterone system nyob rau hauv cov neeg mob uas muaj lub plawv tsis zoo lossis nrog lub raum tsis zoo. Losartan tuaj yeem nce qhov muaj zog ntawm urea thiab creatinine hauv cov ntshav ntshav hauv cov neeg mob uas muaj ob leeg lub raum leeg ntshav liab los yog lub raum leeg mob stenosis ntawm ib lub raum. Cov kev hloov hauv lub raum ua haujlwm tuaj yeem thim rov qab thiab txo qis tom qab kev txiav tawm ntawm cov tshuaj.

Lub hom phiaj ntawm Lozap ntxiv rau cov mob raum ua kom tsis zoo (kev tshem tawm cov ntshav muaj peev xwm tsawg dua 30 ml / min) yog contraindicated.