Baeta - cov lus qhia ntawm kev siv

Daim ntawv txiav txim - ib qho kev daws teeb meem rau kev tswj hwm subcutaneous (s / c): pob tshab, tsis muaj xim (1.2 los yog 2.4 ml hauv lub laub ntawv ntsia rau hauv rab koob syringe, hauv cov duab los qhia pob 1 syringe cwj mem thiab cov lus qhia siv Bayeta).

Cov lus sib xyaw ntawm 1 ml ntawm cov tshuaj:

• cov khoom nquag: exenatide - 250 mcg,
• Cov khoom ua haujlwm pabcuam: metacresol, mannitol, acetic acid, sodium acetate trihydrate, dej rau kev txhaj tshuaj.

Cov Tshuaj Hauv Tshuaj

Cov tshuaj muaj zog ntawm Baeta yog exenatide - 39-amino acid aminopeptide, mimetic ntawm glucagon-zoo li polypeptide receptors.

Nws yog qhov muaj zog agonist ntawm incretins, xws li glucagon-zoo li peptide-1 (GLP-1), uas txhim kho cov haujlwm ntawm β-hlwb, txhim kho cov piam thaj tsis muaj piam thaj rau cov insulin secretion, suppress tsis txaus glucagon tso pa tawm, qeeb qeeb plab zom mov (tom qab nkag mus rau hauv cov hnyuv mus rau hauv cov hlab ntshav dav dav), thiab muaj lwm cov teebmeem hypoglycemic. Yog li, exenatide tuaj yeem txhim kho glycemic tswj nyob rau hauv hom 2 mob ntshav qab zib.

Cov amino acid sib lawv liag ntawm exenatide rau qee yam sib raug rau ntu ntawm tib neeg GLP-1, vim tias cov tshuaj khi rau tib neeg GLP-1 receptors thiab ua kom lawv. Raws li qhov tshwm sim, cov kua nplaum-cov nqaij ua kom sib xyaw thiab tso cov kua dej los ntawm cov kua dej los ntawm β-hlwb ntawm cov txiav ua tiav nrog kev koom tes ntawm cyclic adenosine monophosphate (AMP) thiab / lossis lwm txoj kev sib txuam ntawm cov pa. Exenatide pab txhawb kev tso tawm cov kua dej los ntawm β-cov hlwb thaum muaj kev nce ntxiv ntshav qabzib.

Exenatide sib txawv hauv cov qauv tshuaj thiab cov tshuaj pharmacological los ntawm alpha-glucosidase inhibitors, sulfonylureas, insulin, biguanides, meglitinides, thiazolidinediones thiab D-phenylalanine derivatives.

Kev tswj ntshav qab zib nyob hauv hom 2 ntshav qab zib yog txhim kho los ntawm cov txheej txheem hauv qab no:

• glucose-tiv thaiv cov tshuaj insulin secretion: exenatide ua rau cov piam thaj tsis txaus siab insulin los ntawm pancreatic cells-cov hlwb hauv cov neeg mob uas muaj cov mob hyperglycemic. Raws li theem ntawm cov piam thaj hauv cov ntshav txo qis, insulin secretion txo qis, tom qab mus cuag tus txheej txheem, nws nres, yog li txo qhov kev pheej hmoo ntawm kev mob ntshav qab zib,
• thawj theem ntawm cov tshuaj insulin: nyob rau hauv hom 2 mob ntshav qab zib mellitus, tsis muaj qhov tshwj xeeb hais txog insulin tso lus thaum thawj 10 feeb. Tsis tas li ntawd xwb, qhov ploj ntawm theem no yog qhov ua kom ntxov ntawm β-cell ua haujlwm. Kev siv ntawm exenatide rov qab los yog thim rov qab nce qib thawj thiab qib thib ob ntawm cov tshuaj insulin,
• glucagon secretion: nyob rau hauv cov ntaub ntawv ntawm hyperglycemia, exenatide suppresses ntau dhau ntawm kev zais cia ntawm glucagon, thaum tsis ua txhaum lub glucagon teb rau cov ntshav tsis txaus,
• kev noj zaub mov: exenatide txo qhov qab los noj mov thiab, vim li ntawd, cov khoom noj tau noj ntau,
• pais plab muab nchuav: kev txhawb lub plab zom mov, exenatide ua rau nws khoob.

Kev siv ntawm exenatide hom 2 mob ntshav qab zib mellitus ua ke nrog thiazolidinedione, metformin thiab / los yog sulfonylurea kev npaj pab txo qis kev ntshav sai thiab qabzib cov ntshav qabzib, nrog rau hemoglobin A1c (Hb_A1c), uas txhim kho glycemic tswj.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm sc, exenatide yog qhov nqus tau sai. Qhov nruab nrab siab tshaj plaws (C_max) yog ua tiav hauv 2.1 teev thiab nyiaj txog 211 pg / ml.

Thaj chaw nyob rau hauv qhov nkhaus-lub sijhawm nkhaus (AUC) tom qab sc kev coj noj coj ua exenatide ntawm koob tshuaj 10 μg - 1036 pg × h / ml, qhov ntsuas no nce raws feem ntau ntawm qhov koob tshuaj nce, tab sis tsis cuam tshuam C_maxCov. Tib cov txiaj ntsig tau sau tseg nrog s / rau kev taw qhia ntawm Baeta hauv lub xub pwg, lub plab los yog ncej puab.

Khoom faib ntim (V_d) yog kwv yees li 28,3 litres. Nws yog dhau los feem ntau los ntawm glomerular pom ua raws los ntawm kev kho proteolytic decomposition. Tus tshem yog txog 9,1 l / h. Thaum kawg ib nrab-lub neej (T_½) - 2.4 teev .Tim cov kev siv tshuaj pharmacokinetic ntawm cov tshuaj tsis yog koob tshuaj.

Ntsuas cov tshuaj muaj zog yog txiav txim siab kwv yees li 10 teev tom qab kev saib xyuas ntawm qhov ntsuas exenatide.

Pharmacokinetics hauv rooj plaub tshwj xeeb:

• lub raum tsis ua hauj lwm: nrog cov mob me me mus rau qhov ua haujlwm tsis zoo ntawm qhov ua kom tsis muaj peev xwm tsim cov khoom zoo (CC) 30–80 ml / min, qhov sib txawv tseem ceeb ntawm cov chaw muag tshuaj ntawm exenatide tsis pom, yog li ntawd, tsis tas yuav tsum kho qhov koob tshuaj. Hauv cov neeg mob uas mob raum ua tsis tiav los ntawm kev lim ntshav, kev tshem ntawm cov tshuaj txo kom tsawg mus txog 0.9 l / h (hauv cov neeg mob noj qab haus huv - 9.1 l / h),
• lub siab ua haujlwm tsis txaus siab: qhov tseem ceeb sib txawv hauv plasma concentration ntawm exenatide tsis pom, vim tias cov tshuaj tawm tsis zoo tsuas yog los ntawm lub raum,
• hnub nyoog: pharmacokinetics ntawm exenatide tsis tau kawm txog cov menyuam yaus, hauv cov tub ntxhais hluas hnub nyoog 12-16 xyoo nrog hom 2 mob ntshav qab zib mellitus, thaum siv exenatide ntawm koob tshuaj 5 μg, pharmacokinetic tsis zoo ib yam li cov neeg mob hauv cov neeg laus tau qhia, hauv cov neeg laus tsis muaj kev hloov pauv hauv cov yam ntxwv pharmacokinetic, yog li, kev hloov kho koob tsis yog yuav tsum tau
• poj niam txiv neej thiab haiv neeg: qhov sib txawv tseem ceeb hauv pharmacokinetics ntawm exenatide ntawm cov poj niam thiab tus txiv neej tsis tau pom, qhov kev sib tw no tseem tsis muaj qhov tshwm sim uas cuam tshuam rau qhov no,
• lub cev qhov hnyav: tsis muaj qhov sib cuam tshuam tseem ceeb ntawm lub cev qhov ntsuas thiab cov kws kho tshuaj exenatide.

Kev ntsuas rau siv

Raws li kev ntsuas tshuaj rau ntshav qab zib hom 2, Bayete yog siv ntxiv rau kev kho kev noj haus thiab kev tawm dag zog kom ua tiav glycemic tswj.

Hauv kev kho ua ke ntawm hom 2 mob ntshav qab zib mellitus, Bayete yog siv los txhim kho glycemic tswj hauv cov mob hauv qab no:

• ntxiv rau metformin / sulfonylurea derivative / thiazolidinedione / metformin ua ke + sulfonylurea derivative / metformin + thiazolidinedione kev sib xyaw,
• ntxiv rau kev sib xyaw ua ke ntawm basal insulin + metformin.

Dosage daim ntawv

Kev daws rau subcutaneous thawj coj.

1 ml ntawm cov tshuaj muaj:

yam tshuaj: exenatide 250 mcg,

tus zam: sodium acetate trihydrate 1.59 mg, acetic acid 1.10 mg, mannitol 43.0 mg, metacresol 2.20 mg, dej rau kev txhaj tshuaj q.s. txog li 1 ml.

Cov xim tsis muaj pob tshab.

Cov yam ntxwv dav dav ntawm cov tshuaj

Baeta cov tshuaj yog qhov kev daws tsis tau daws rau subcutaneous Txoj kev lis ntshav. Cov tshuaj ua haujlwm nquag ntawm cov tshuaj yog exenatide, nws kuj muaj ib qho me me ntawm sodium acetate trihydrate, metacresol, mannitol, acetic acid, dej distilled. Lawv tso tawm cov tshuaj nyob rau hauv daim ntawv ntawm ampoules (250 mg), txhua tus muaj cwj mem tshwj xeeb nrog lub ntim ntawm 1.2 thiab 2.4 ml.

Cov neeg mob uas tau noj cov tshuaj no tau pom tias yuav txo cov ntshav qab zib vim qhov kev ua no:

1. Byeta txhim kho kev tso tawm ntawm cov kua dej los ntawm cov kab mob parenchyma nrog kev nce ntxiv ntawm cov piam thaj hauv cov ntshav ntawm tus neeg.
2. Kev siv tshuaj insulin nres nyob rau lub sijhawm thaum muaj txo suab thaj tsawg.
3. Cov kauj ruam kawg yog txhawm rau tswj koj cov ntshav piam thaj.

Hauv cov tib neeg kev txom nyem los ntawm kev mob ntshav qab zib thib ob, kev siv tshuaj yaj yeeb ua rau muaj kev hloov pauv:

• Kev tiv thaiv ntawm kev tshaj tawm glucagon ntau lawm, uas tswj cov insulin.
• Kev txwv tsis pub leeg lub plab.
• Tsis qab los noj mov.

Thaum cov tshuaj muaj tshuaj subcutaneously, cov tshuaj nquag pib ua tam sim ntawd thiab mus txog nws cov txiaj ntsig zoo tshaj plaws tom qab ob teev.

Cov nyhuv ntawm cov tshuaj yog kiag li tso tseg tsuas yog tom qab ib hnub.

Cov lus qhia rau kev siv tshuaj

Tsuas yog tus kws kho mob tau tuaj yeem sau tshuaj, tsis muaj qhov xwm txheej twg koj tus kheej noj tshuaj. Tom qab tau txais Baeta cov tshuaj, cov lus qhia rau kev siv yuav tsum tau ua tib zoo kawm.

Kev qhia tias siv cov tshuaj no yog type 2 mob ntshav qab zib nrog kev kho mono- lossis kho sab nraud. Nws siv thaum nws tsis tuaj yeem tswj xyuas qhov theem ntawm glycemia. Cov tshuaj tuaj yeem siv ua ke nrog nrog txhais tau tias:

1. Metformin
2. Thiazolidinedione,
3. sulfonylurea derivatives,
4. kev sib xyaw ntawm metformin, sulfonylurea,
5. kev sib xyaw ntawm metformin thiab thiazolidinedione.

Cov tshuaj ntawm cov tshuaj yog 5 μg ob zaug ib hnub rau ib teev ua ntej noj zaub mov tseem ceeb. Nws yog txhaj subcutaneously rau hauv caj npab, ncej puab lossis plab. Tom qab ib hlis uas tau txais kev kho mob zoo, kev noj ntxiv tau nce rau 10 mcg ob zaug ib hnub. Yog tias cov tshuaj siv ua ke nrog sulfonylurea derivatives, qhov koob tshuaj ntawm tom kawg yuav tsum raug txo kom tsis txhob muaj cov neeg mob ntshav qab zib hauv lub xeev.

Cov cai hauv qab no rau kev tswj hwm cov tshuaj yuav tsum tau ua raws:

• nws tsis tuaj yeem siv tom qab noj mov,
• nws yog qhov tsis xav kom txhaj tshuaj intramuscularly lossis intravenously,
• yog tias cov tshuaj tov nrog huab thiab hloov xim, nws yog qhov zoo dua los siv nws,
• yog tias cov khoom tau pom hauv kev daws, koj yuav tsum tso tseg txoj cai tswj hwm tshuaj,
• thaum lub sij hawm Bayeta txoj kev kho, kev tsim cov tshuaj tiv thaiv yog ua tau.

Cov tshuaj yuav tsum khaws cia hauv ib qho chaw tiv thaiv los ntawm lub teeb thiab los ntawm cov menyuam yaus me. Kev ntsuas qhov kub thiab txias yuav tsum pom nyob hauv qhov nruab nrab ntawm 2 txog 8 degrees, yog li nws zoo dua khaws cov tshuaj rau hauv lub tub yees, tab sis tsis txhob khov nws.

Lub txee lub neej ntawm cov khoom yog 2 xyoos, thiab kev daws teeb meem hauv cov xaum xaum yog 1 hli ntawm qhov kub tsis tshaj 25 degrees.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Nws yog kev daws rau subcutaneous thawj coj. Hauv koob txhaj tshuaj tuaj yeem yog qhov 1.2 lossis 2.4 ml ntawm cov tshuaj nquag. Cov pob muaj ib pob xaum.

Muaj pes tsawg leeg suav nrog:

• exenatide -250 mcg,
• sodium acetate trihydrate,
• glacial acetic acid,
• mannitol
• metacresol
• dej rau kev txhaj tshuaj.

"Baeta Ntev" yog hmoov los npaj rau kev ncua, muag ua tiav nrog cov kuab tshuaj. Tus nqi ntawm hom tshuaj no ntau dua, nws siv tsawg zaus. Nws yog muab tsuas subcutaneously.

Pharmacological kev txiav txim

Nws muaj cov nyhuv hypoglycemic. Tseem ceeb txhim kho cov ntshav qabzib tswj, ua kom lub luag haujlwm ntawm pancreatic beta hlwb, txhawb kev tso zis ntau dhau ntawm glucagon, txhim kho cov piam thaj tsis pub muaj ntshav qabzib tso cov kua dej thiab ua kom lub plab zom mov.

Exenatide txawv nyob rau hauv muaj pes tsawg leeg los ntawm insulin, sulfonylurea thiab lwm yam, yog li nws tsis tuaj yeem ua lawv qhov hloov hauv kev kho.

Cov neeg mob uas siv cov tshuaj Bayeta txo qis nws lub siab, ua kom lub cev yuag, thiab zoo rau lub zoo.

Cov Yuav Tsum Muaj

• Hypersensitivity rau Cheebtsam,
• Cov mob hnyav ntawm lub plab zom plab nrog concomitant gastroparesis,
• Keeb kwm ntawm kab mob ntshav qab zib ketoacidosis,
• Mob raum tsis ua haujlwm,
• Yam 1 ntshav qab zib
• Cev xeeb tub thiab lactation
• Lub hnub nyoog qis dua 18 xyoo.

Cov lus qhia rau siv (qauv thiab ntau npaum li cas)

Cov tshuaj yog muab tshuaj subcutaneously hauv plab, xub pwg, duav lossis pob tw. Qhov chaw txhaj tshuaj yuav tsum tau hloov tas li. Pib noj nrog 5 mcg ib hnub ob zaug ua ntej noj mov. Koj tuaj yeem nce ntxiv qhov koob tshuaj rau 10 mcg ob zaug ib hnub tom qab 4 lub lis piam, yog tias qhia. Nrog rau kev kho ua ke, kev kho qhov sib txawv ntawm sulfonylurea thiab insulin derivatives yuav tsum tau.

Sab sij huam

• Kev mob hypoglycemia (nrog rau kev kho mob ua ke),
• Tsis qab los noj mov
• Yeeb Ncuab
• Gastroesophageal reflux,
• Saj tsis taus,
• Mob plab
• Xeev siab, ntuav,
• Zawv plab
• Cem quav
• Flatulence
• Kev nkees nkees
• Kiv taub hau
• Mob taub hau
• Kev tsis haum rau tshuaj cev,
• Cov kev tawm tsam tsis haum rau qhov chaw txhaj tshuaj,
• Anaphylactic kev poob siab,
• Hyperhidrosis,
• Lub cev qhuav dej
• Mob ncauj taub hau (tsis tshua muaj)
• Mob raum tsis ua hauj lwm (tsawg).

Noj ntau dhau

Cov tsos mob hauv qab no yog qhov ua tau nrog kev noj tshaj:

• Kev ntshav siab. Nws nthuav tawm nws tus kheej li qhov tsis muaj zog, xeev siab thiab ntuav, tsis nco qab txog nws txoj kev poob thiab kev loj hlob ntawm coma, kev tshaib plab, kiv taub hau, thiab lwm yam nrog rau kev kawm siab, nws txaus noj cov khoom muaj txiaj ntsig nyob rau hauv carbohydrates. Thaum muaj mob ntshav qis thiab hnyav, yuav tsum tau txhaj tshuaj glucagon lossis dextrose tov, tom qab coj tus neeg mus rau hauv kev nco qab - cov zaub mov uas muaj cov khoom noj uas muaj carbohydrate. Nco ntsoov tias tom qab ntawv ceeb toom kom koj hu rau tus kws paub tshwj xeeb kom hloov kho koob tshuaj.
• Cov mob hnyav, nrog nrog xeev siab thiab ntuav. Kev kho mob thaum tsis pom kev thov, kev mus pw hauv tsev kho mob tau.

Yeeb tshuaj sib cuam tshuam

Koj yuav tsum sib tham nrog koj tus kws kho mob noj tshuaj uas xav tau sai ntawm kev mob plab zom mov, vim tias "Baeta" ua rau lub plab zom mov qis thiab vim li ntawd, qhov tshwm sim ntawm cov tshuaj no.

Cov tshuaj tua kab mob thiab tshuaj zoo sib xws yuav tsum siv 1 teev ua ntej kev txhaj tshuaj ntawm "Bayeta" lossis thaum lub sijhawm noj mov thaum cov tshuaj no tsis siv.

Txo cov concentration ntawm digoxin, lovastatin, tsub kom lub sijhawm ntawm kev siab tshaj plaws ntawm lisinopril thiab warfarin.

Feem ntau, qhov tshwm sim ntawm cov nyhuv ntawm lwm cov tshuaj muaj tsawg kawm. Qhov no tsis yog hais tias qee qhov ntsuas phom sij txog lub neej tau sau tseg thaum sib koom ua ke. Yog li, lo lus nug ntawm kev sib txuas ntawm Bayetoy kev kho mob nrog lwm cov tshuaj tau sib tham ntawm tus kheej nrog tus kws kho mob tau koom.

Cov lus qhia tshwj xeeb

Tsis muab rau noj tom qab noj mov. Tsis txhob txhaj tshuaj rau pob ntseg los yog intramuscularly.

Yog tias muaj kev ncua hauv kev daws los yog qhov sib thab, qhov tshuaj yuav tsum tsis txhob siv.

Nws yog kuaj pom tias cov tshuaj cuam tshuam rau lub cev qhov hnyav, txo qhov qab los noj mov.

Tsis siv rau hauv cov neeg mob raum tsis zoo.

Nws tuaj yeem ua rau mob pancreatitis, tab sis nws tsis muaj cov nyhuv carcinogenic.

Tus neeg mob yuav tsum saib xyuas qhov kev hloov pauv ntawm lawv kev noj qab haus huv lub sijhawm kho. Nrog txoj kev loj hlob ntawm tus mob sai, koj yuav tsum tam sim ntawd sab laj nrog tus kws kho mob thiab tsum tsis noj.

Tsis siv los hloov pauv cov insulin.

Thaum noj ua ke nrog metformin lossis sulfonylurea, nws yuav cuam tshuam lub peev xwm ntawm kev tsav tsheb. Qhov teeb meem no tau daws nrog koj tus kws kho mob.

PAB. Cov tshuaj yuav muab faib tawm los ntawm cov tshuaj noj!

Siv rau lub sijhawm menyuam yaus thiab hnub nyoog laus

Tsis muaj ntaub ntawv qhia txog cov nyhuv ntawm cov tshuaj ntawm lub cev ntawm cov menyuam hnub nyoog qis dua 18 xyoo, yog li ntawd, nws tsis yog siv rau lawv txoj kev kho. Txawm hais tias muaj kev paub dhau los ntawm kev siv rau cov menyuam yaus txij li 12 xyoo, cov qauv qhia tau kho zoo ib yam li cov laus. Tab sis ntau dua lwm txhais tau tias siv tau.

Yuav siv tau los kho ntshav qab zib hauv cov neeg laus. Txawm li cas los xij, koj yuav tsum saib xyuas cov neeg ntawm cov neeg uas muaj keeb kwm ntawm ketoacidosis lossis muaj kev ua haujlwm tsis zoo hauv lub raum. Cov neeg mob zoo li no raug qhia kom ua cov kev ntsuas tas li.

Piv nrog tshuaj zoo sib xws

Cov tshuaj muaj nqi kim no muaj cov qauv tshuaj tiv thaiv kab mob zoo kuj tuaj yeem siv los kho ntshav qab zib. Cia peb xav txog lawv cov khoom hauv ntau yam ntxiv.

Kev siv cov analogues yog tau tsuas yog kev tso cai los ntawm tus kws kho mob tuaj koom. Kev siv tus kheej yog txwv!

Cov neeg nco ntsoov tias cov kev mob tshwm sim tsis tshua tshwm sim, feem ntau nrog kev xaiv tshuaj tsis haum. Cov txiaj ntsig ntawm kev poob phaus yog hais, txawm hais tias tsis yog txhua tus neeg mob. Feem ntau, "Bayeta" muaj cov kev ntsuam xyuas zoo ntawm cov ntshav qab zib nrog kev paub dhau los.

Alla: “Kuv tau siv tshuaj yeeb los tau ob xyoos.Thaum lub sijhawm no, qab zib rov qab rau qhov qub, thiab qhov hnyav poob los ntawm 8 kg. Kuv nyiam tias nws ua haujlwm sai thiab tsis muaj kev phiv tshuaj. Kuv qhia koj. ”

Oksana: "Baeta" yog ib qho kev kho mob kim, tab sis nws pab muaj ntshav qab zib. Qab zib cia rau hauv tib theem, uas Kuv txaus siab. Kuv tsis tuaj yeem hais tias nws txo qhov hnyav, tab sis tsawg kawg yog kuv tsum tsis ua kom rov zoo li qub. Tab sis kev qab los noj yeej tswj tau nws. Kuv xav noj tsawg dua, thiab vim li ntawd qhov hnyav tau ntev ntev nyob ntawm tus nqi. Feem ntau, Kuv txaus siab txog hom tshuaj no. ”

Igor: “Lawv tau muab cov tshuaj no los kho thaum kuv cov ntsiav tshuaj qub tsis them. Feem ntau, txhua yam hnav, tshwj tsis yog tus nqi siab. "Bayetu" tsis tuaj yeem tau txais ntawm cov txiaj ntsig, koj yuav tsum xaj ua ntej. Qhov no yog qhov tsis yooj yim xwb. Kuv tsis xav siv analogues tsis tau, tab sis nws pheej yig. Txawm hais tias kuv tuaj yeem pom tias kuv xav tias cov nyhuv cuam tshuam sai heev - tsuas yog ob peb lub lis piam tom qab pib qhov kev noj tshuaj. Lub siab poob qis, yog li nws kuj poob phaus tib lub sijhawm. ”

Xaus

"Baeta" yog ib qho tshuaj zoo uas muaj npe nrov hauv cov neeg mob ntshav qab zib. Nws yog feem ntau sau tseg thaum lwm cov tshuaj txiav tsis ua. Thiab tus nqi siab tau tawm los ntawm cov txiaj ntsig ntxiv ntawm kev poob phaus thiab tsis tshua pom muaj cov kev mob tshwm sim hauv cov neeg mob kho. Yog li, "Bayeta" feem ntau muaj kev tshuaj xyuas zoo los ntawm ob qho tib si ntawm kev siv tshuaj thiab cov kws kho mob.

Kev taw qhia thiab contraindications

Qhov ua tau zoo ntawm cov tshuaj tau muaj pov thawj hauv 6 qhov kev sim kho uas qhov kev txhaj ib zaug ntawm exenatide (2 mg) piv nrog lwm cov tshuaj. Cov kev tshawb fawb no koom nrog cov neeg uas twb tau txais kev kho mob ntshav qab zib yooj yim (noj zaub mov + ua kom lub cev, qee zaum nrog kev kho mob uas twb muaj lawm). Cov neeg mob tau muaj HbA1c ntawm nruab nrab ntawm 7.1 thiab 11% thiab lub cev lub cev ruaj khov nrog qhov ntsuas BMI ntawm 25 txog 45 kg / m2.

Ob qhib kev sib piv ntawm cov tshuaj kav ntev li 30 lossis 24 lub lis piam. Tag nrho ntawm 547 tus neeg, ntau dua 80% ntawm cov neeg uas siv cov tshuaj metformin thiab sulfonylurea lossis pioglitazone, koom nrog txoj kev tshawb no. Kev npaj-kev npaj tawm mus tau zoo muab qhov zoo tshaj plaws nrog HbA1c: HbA1c txo qis los ntawm 1.9% thiab 1.6%, ua ntu zus.

Hauv kev tshawb nrhiav ob zaug uas tau siv 26 lub lis piam, cov kws tshawb fawb sib piv sitagliptin, pioglitazone, thiab exenatide. Txoj kev tshawb no koom nrog 491 tus neeg uas tsis teb rau kev kho mob nrog metformin. Thaum kho nrog exenatide, qhov siab ntawm HbA1c poob qis los ntawm 1.5%, uas yog muaj zog ntau dua nrog pioglitazone thiab sitagliptin. Thaum noj "Bayeta", lub cev zaws txo los ntawm 2.3 kg.

Cov tshuaj yog contraindicated thaum cev xeeb tub thiab lactation. Yog tias cev xeeb tub ua tiav lawm, cov tshuaj yuav tsum tau tsum tsis pub muaj tsawg kawg 3 hlis ua ntej. Cov neeg mob hnub nyoog qis dua 18 xyoo tsis tuaj yeem siv cov khoom lag luam vim tias nws tsis tau kawm nyob rau hauv pawg no. Nrog raum tsis ua haujlwm, muaj kev pheej hmoo ntawm kev phiv. Cov neeg mob nrog creatinine tshem tawm hauv qab 30 ml / min yuav tsum tsis txhob noj tshuaj.

Ib qho tshuaj uas yuav tsum tau noj tsuas yog ib hlis ib zaug yog yooj yim. Ntawm qhov tod tes, ib qho yeeb tshuaj uas lingers nyob rau hauv lub cev rau tsawg kawg 10 lub lis piam tseem muaj qhov peev xwm nce ntxiv rau cov teeb meem ntev.

Kev sib txuam

Exenatide yuav cuam tshuam rau kev mob plab, tus nqi thiab npaum li cas nqus ntawm lwm cov tshuaj. Ib qho tshuaj noj tuaj yeem ua rau muaj kev pheej hmoo ntawm hypoglycemia thaum noj tshuaj insulin thiab sulfonylurea. Kev ua ke ntawm kev siv tshuaj tiv thaiv qhov ncauj tau pom los txo cov ntshav coagulation.

Lub ntsiab analogues (nrog tshuaj zoo sib xws) ntawm cov tshuaj:

Lub tswv yim ntawm tus neeg mob thiab tus kws kho mob txog cov tshuaj.

Tus kws kho mob tau sau tshuaj, vim tias lwm yam tshuaj tsis ua haujlwm. Kuv yuav tsum hais tam sim ntawd - ib qho khoom siv kim heev. Kuv yuav tsum tau yuav ob peb pob, uas raug nqi ib puag ncig. Txawm li cas los xij, cov nyhuv yog tsim nyog hauv kev yuav khoom - qhov mob tau zoo dua ho. Kuv tsis xav tias muaj tej yam tshwm sim tsis kaj siab. Lub 'meter' qhia cov nqi tseem ceeb rau ob peb lub hlis.

"Baeta" yog ib qho tshuaj kim kim uas tau sau tseg rau qhov tsis muaj txiaj ntsig ntawm lwm cov tshuaj tiv thaiv kab mob siab. Kev siv mus sij hawm ntev (raws li cov lus qhia raug cai) cov lus suav txo glycemia thiab txhim kho cov neeg mob, txawm li cas los xij, nws "pheej yig".

Boris Alexandrovich, mob ntshav qab zib

Nqe (hauv Lavxias Federation)

Tus nqi ntawm kev kho mob yog 9000 rubles rau 4 lub lis piam. Lwm cov tshuaj tiv thaiv kab mob ntshav pheej yig dua, metformin (tag nrho, 2 g / hnub) tus nqi qis dua 1000 rubles hauv ib hlis.

Tswv yim! Ua ntej yuav ib qho tshuaj twg, cov kws tshaj lij yuav tsum tau sab laj. Kev xav tsis tau tus kheej kev noj tshuaj tuaj yeem ua rau qhov tsis muaj kev cia siab thiab muaj kev siv nyiaj txiag hnyav. Tus kws kho mob yuav pab qhia txog kev kho mob kom raug thiab siv tau, yog li ntawm lub cim xub thawj koj yuav tsum nrhiav kev pab kho mob.

Tus nqi ntawm cov tshuaj thiab tshuaj xyuas

Cov tshuaj Baeta tuaj yeem raug yuav ntawm txhua lub tsev muag tshuaj lossis ua ib qho xaj nyob ntawm lub tsev muag tshuaj online. Nws yuav tsum raug sau tseg tias cov tshuaj tsuas yog muag tshuaj nkaus xwb. Txij li thaum lub chaw tsim khoom ntawm cov khoom no yog Sweden, raws li nws tus nqi yog siab heev.

Yog li, tsis yog txhua tus neeg uas muaj mob ntsuas ntshav qab zib muaj peev xwm them taus mus yuav cov tshuaj no. Tus nqi sib txawv raws li daim ntawv tso tawm cov nyiaj:

• 1.2 ml syringe mem - los ntawm 4246 txog 6398 rubles,
• 2.4 ml koob txhaj tshuaj - los ntawm 5301 txog 8430 rubles.

Tsis ntev los no tau tshawb fawb txog kev lag luam, uas tau kawm los ntawm kev xaiv tus neeg mob uas tau siv cov tshuaj no. Xa mus rau cov tshuaj Byeta, uas nws cov kev txheeb xyuas pom tias muaj cov tshwm sim tsis zoo hauv qab no:

1. Kev cuam tshuam ntawm cov hlab ntsha: nkees, cuam tshuam lossis tsis hnov ​​qab.
2. Hloov hauv cov metabolism thiab zaub mov noj: poob phaus, lub cev qhuav dej yog los ntawm ntuav.
3. Ib qho tshwm sim uas tsis tshua pom tshwm sim ntawm anaphylactic.
4. Kev zom plab zom mov thiab pathologies: muaj zog roj tsim, cem quav, mob nraub qaum (qee zaum).
5. Hloov pauv tso zis: lub raum tsis ua haujlwm, nce creatinine qib, lub raum tsis ua haujlwm lossis nws qhov kev ua tsis zoo.
6. Kev ua xua rau tawv nqaij: alopecia (plaub hau poob), khaus, urticaria, angioedema, maculopapular ua pob.

Yog lawm, qhov tsis zoo yog qhov siab ntawm tus nqi ntawm cov tshuaj, nws yog vim li no tias ntau tus neeg mob ntshav qab zib tawm lawv cov kev txheeb xyuas hauv Is Taws Nem. Tab sis, txawm tias qhov no, cov tshuaj yeej txo cov ntshav siab nyob hauv tus neeg mob cov ntshav thiab pab tua nyhav dhau heev.

Ntxiv mus, vim yog qhov peculiarities ntawm nws cov nyhuv kho, nws tsis ua rau cov mob ntshav qab zib tsawg.

Analogues ntawm cov tshuaj

Yog tias thaum tus neeg mob tsis tuaj yeem siv txoj hauv kev daws teeb meem lossis nws xav tias muaj qhov tshwm sim tsis zoo, tus kws kho mob tuaj yeem hloov kho kho kho. Qhov no tshwm sim hauv ob txoj hauv kev - los ntawm kev hloov qhov ntau npaum ntawm cov tshuaj lossis los ntawm tso tseg kiag li. Hauv rooj plaub thib ob, nws yog ib qho tsim nyog yuav tsum xaiv cov tshuaj analog uas yuav muaj tib yam kev kho mob thiab tsis ua mob rau lub cev ntshav qab zib.

Xws li, Baeta tsis muaj cov lus zoo sib xws. Tsuas yog AstraZeneca thiab Bristol-Myers Squibb Co (BMS) cov tuam txhab tsim tawm 100% cov yeeb yaj kiab ntawm cov tshuaj no (cov tshuaj generics). Muaj ob hom tshuaj nyob ntawm kev lag luam tshuaj ntawm Lavxias, uas zoo sib xws hauv lawv cov txiaj ntsig kho kom zoo. Cov no suav nrog:

1. Victoza yog ib hom tshuaj uas zoo ib yam li Baeta, yog ib qho tshuaj muaj zog. Cov tshuaj yeeb yaj kiab yog tseem tsim nyob rau hauv daim ntawv ntawm koob txhaj tshuaj tiv thaiv rau subcutaneous infusions hauv ntshav qab zib hom 2. Kev siv cov tshuaj tsis tu ncua yuav pab txo qis qib ntawm glycated hemoglobin rau 1.8% thiab poob qhov ntxiv 4-5 kg ​​thaum lub xyoo ntawm kev kho. Nws yuav tsum raug sau tseg tias tsuas yog tus kws kho mob tuaj yeem txiav txim siab qhov tsim nyog ntawm ib hom tshuaj tshwj xeeb. Tus nqi nruab nrab (2 koob txhaj ntawm 3 ml) yog 10,300 rubles.
2. Januvia yog ib qho ua rau kom cov ntshav qab zib tsawg nyob hauv kev kho mob ntshav qab zib hom 2. Muaj nyob hauv ntsiav tshuaj daim ntawv. Tus nqi nruab nrab ntawm cov tshuaj (28 units, 100 mg) yog 1672 rubles, uas yog tus nqi pheej yig ntawm cov tshuaj hauv cov lus nug. Tab sis lo lus nug ntawm yam kev kho mob twg zoo dua rau kev noj qab haus huv tseem nyob hauv kev txawj txaus ntawm kws kho mob.

Thiab yog li, cov tshuaj Bayeta yog ib tus neeg sawv cev hypoglycemic zoo. Nws cov txiaj ntsig kho muaj qee cov yam ntxwv uas pab ua tiav kev tswj glycemic. Txawm li cas los xij, cov tshuaj nyob rau qee kis tsis tuaj yeem siv, nws tseem tuaj yeem ua rau muaj kev tsis zoo.

Yog li ntawd, kev noj tshuaj rau tus kheej tsis tsim nyog. Nws yog ib qho tsim nyog yuav tau coj mus ncig ua si rau kws kho mob uas tawm tsam qhov kev xav ntawm kev siv tshuaj, suav txog tus yam ntxwv ntawm lub cev ntawm txhua tus neeg mob. Nrog rau txoj kev noj tshuaj zoo thiab ua raws txhua txoj cai rau kev qhia txog kev daws teeb meem, koj tuaj yeem txo cov piam thaj rau theem ib txwm thiab tshem tawm cov tsos mob ntawm hyperglycemia. Daim vis dis aus hauv tsab xov xwm no hais txog tshuaj kho mob ntshav qab zib.

Cov chaw muag tshuaj

Exenatide (Exendin-4) yog glucagon zoo li polypeptide receptor agonist thiab yog 39-amino acid amidopeptide. Cov ntau zuj zus, xws li cov glucagon-zoo li peptide-1 (GLP-1), txhim kho cov kua dej tsis txaus rau cov kua dej, txhim kho beta ntawm tes ua haujlwm, txwv tsis pub muaj ntshav qabzib ntau thiab ua rau lub plab zom mov tom qab lawv nkag mus rau hauv cov ntshav tawm ntawm txoj hnyuv. Exenatide yog lub zog loj zuj zus uas ua rau cov ntshav qabzib-insulin muaj peev xwm ua rau muaj cov ntshav qabzib ntau yam thiab muaj lwm yam teebmeem ntshav qabzib ntau ntxiv rau cov neeg mob ntshav qab zib hom 2.

Cov amino acid sib lawv liag ntawm exenatide ib feem sib raug rau ntu ntawm tib neeg GLP-1, los ntawm qhov uas nws khi thiab ua rau GLP-1 cov neeg txais kev pabcuam hauv tib neeg, uas ua rau muaj kev sib txuas ntxiv rau cov piam thaj thiab kev zais ntawm insulin los ntawm pancreatic beta hlwb nrog kev koom tes ntawm cyclic AMP thiab / lossis lwm yam kev cuam tshuam ntawm cov ntshav txoj kev. Exenatide txhawb kev tso tawm ntawm insulin los ntawm beta hlwb nyob ib puag ncig muaj kev nce siab ntxiv ntawm cov piam thaj. Exenatide sib txawv hauv cov qauv tshuaj thiab cov tshuaj pharmacological los ntawm insulin, sulfonylurea derivatives, D-phenylalanine derivatives thiab meglitinides, biguanides, thiazolidinediones thiab alpha-glucosidase inhibitors.

Exenatide txhim kho glycemic tswj nyob rau hauv cov neeg mob uas muaj ntshav qab zib hom 2 vim yog cov haujlwm hauv qab no.

Cov qabzib-insulin secretion: hauv hyperglycemic tej yam kev mob, exenatide ua rau cov piam thaj tsis muaj peev xwm tso cov kua dej ntawm cov kua dej los ntawm pancreatic beta hlwb. Qhov insulin secretion tso tseg thaum cov concentration ntawm cov piam thaj hauv cov ntshav txo qis thiab nws nce mus rau qhov qub, yog li txo cov kev pheej hmoo ntawm cov ntshav qog ntshav qab zib.

Thawj theem ntawm cov tshuaj insulin: Kev siv tshuaj insulin thaum thawj 10 feeb, hu ua "thawj theem ntawm cov tshuaj insulin", tsis tuaj rau cov neeg mob ntshav qab zib hom 2. Tsis tas li ntawd xwb, qhov poob ntawm thawj theem ntawm cov tshuaj insulin yog ib qho kev ua haujlwm thaum ntxov ntawm beta cell ua haujlwm hauv hom 2 ntshav qab zib. Kev tswj hwm ntawm exenatide rov qab los yog hloov kho tau zoo ntau theem ntawm thawj thiab theem ob ntawm cov tshuaj insulin hauv cov neeg mob uas muaj ntshav qab zib hom 2.

Glucagon tso pa tawm: nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus tawm tsam keeb kwm ntawm hyperglycemia, kev tswj hwm ntawm exenatide suppresses zais cia ntau dhau ntawm glucagon. Txawm li cas los xij, exenatide tsis cuam tshuam rau lub cev glucagon teb li cas rau kev mob ntshav qab zib.

Kev nrhiav zaub mov: kev tswj hwm ntawm exenatide ua rau muaj kev poob qab los noj mov thiab txo qis hauv kev noj zaub mov.

Phaj plab muab nchuav: nws tau pom tias kev tswj hwm ntawm exenatide inhibits lub plab zom mov, uas ua rau nws qeeb. Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, kev kho mob exenatide hauv kev kho mob monotherapy thiab nyob rau hauv kev sib xyaw nrog metformin thiab / lossis sulfonylurea kev npaj ua rau txo qis ntawm cov ntshav qabzib concentration, postprandial ntshav qabzib concentration, thiab HbA1c, yog li txhim kho glycemic tswj hauv cov neeg mob no.

Cov Tshuaj Pharmacokinetics

Tom qab ua haujlwm subcutaneous rau cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, exenatide nrawm nrawm thiab nce mus txog qhov nruab nrab ntshav ntau tom qab 2.1 teev. Qhov nruab nrab siab tshaj plaws (Cmax) yog 211 pg / ml thiab tag nrho thaj tsam hauv qab cov phiaj xwm qhov siab-sijhawm (AUC)_{0-rau cov}) yog 1036 pg x h / ml tom qab subcutaneous thawj coj ntawm ib koob tshuaj 10 exg exenatide. Thaum tso tawm rau exenatide, AUC nce rau hauv kev faib ua feem rau cov koob tshuaj nce ntxiv ntawm 5 μg txog 10 μg, thaum tsis muaj qhov sib luag ntawm Cmax. Tib cov txiaj ntsig tau pom nrog kev coj ua subcutaneous ntawm exenatide hauv plab, ncej puab lossis xub pwg.

Qhov ntim ntawm kev faib tawm ntawm exenatide tom qab subcutaneous tswj hwm yog 28.3 litres.

Kev ntsuas phoo thiab nthuav tawm

Exenatide yog feem ntau raug ntog los ntawm glomerular pom ua raws los ntawm kev kho mob proteolytic kev ua haujlwm. Exenatide tshem tawm yog 9.1 l / teev thiab qhov kawg ib nrab-lub neej yog 2.4 teev. Cov ntsej muag pharmacokinetic ntawm exenatide yog koob tshuaj ywj siab. Ntsuas qhov ntau ntawm exenatide raug txiav txim kwv yees li 10 teev tom qab noj tshuaj.

Cov pab pawg neeg tshwj xeeb

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Hauv cov neeg mob uas muaj mob me me los yog ua rau lub raum tsis ua haujlwm (kev tsim kho lub peev xwm ntawm 30-80 ml / min), exenatide tshem tawm tsis txawv ntau ntawm kev tshem tawm hauv cov ncauj lus nrog lub raum kev ua haujlwm, yog li ntawd, kev kho tshuaj tsis tas yuav tsum tau. Txawm li cas los xij, hauv cov neeg mob uas mob raum ua rau lub raum tsis ua haujlwm, kev txiav txim siab nruab nrab yog txo mus rau 0.9 l / h (piv rau 9.1 l / teev hauv cov ntsiab lus noj qab haus huv).

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Txij li thaum exenatide tsuas yog ua tawm los ntawm lub raum, nws ntseeg tau tias qhov ua tsis tau haujlwm hepatic tsis hloov qhov kev ua kom zoo ntawm exenatide hauv cov ntshav. Cov neeg laus Lub hnub nyoog tsis cuam tshuam rau pharmacokinetic cov yam ntxwv ntawm exenatide. Yog li, cov neeg laus laus tsis tas yuav tsum ua qhov hloov kho koob tshuaj.

Cov menyuam Cov pharmacokinetics ntawm exenatide hauv cov menyuam yaus tsis tau kawm.

Cov Hluas (12 txog 16 xyoo)

Hauv kev muab tshuaj pharmacokinetic ua nrog cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus hauv pawg hnub nyoog ntawm 12 txog 16 xyoo, kev tswj hwm ntawm exenatide ntawm koob tshuaj 5 μg tau nrog pharmacokinetic tsis zoo ib yam li cov uas tau pom nyob hauv cov neeg laus.

Tsis muaj qhov sib txawv ntau qhov sib txawv ntawm tus txiv neej thiab poj niam hauv pharmacokinetics ntawm exenatide. Kwv Txhiaj Cov haiv neeg tsis muaj qhov cuam tshuam tseem ceeb ntawm pharmacokinetics ntawm exenatide. Tsis tas yuav muab hloov kho los ntawm haiv neeg keeb kwm.

Rog cov neeg mob

Tsis muaj qhov tshwm sim pom tseeb ntawm kev ntsuas lub cev (BMI) thiab exenatide pharmacokinetics. Koob tshuaj hloov kho raws li BMI yog tsis xav tau.

Chaw tsim tshuaj paus

Baxter Tshuaj Kho Mob ELC, USA
927 South Curry Pike, Bloomington, Indiana, 47403, Tebchaws Asmeskas
Baxter Tshuaj Kho Mob LLC, USA
927 South Curry Pike, Bloomington, Indiana 47403, Asmeskas

TUS NEEG TUAJ YEEM (THAWJ COV NEEG)

1. Baxter Pharmaceutical Solutions ELC, Tebchaws Asmeskas 927 South Curry Pike, Bloomington, Indiana, 47403, Tebchaws Asmeskas Baxter Cov Tshuaj Kho Mob LLC, Tebchaws Asmeskas 927 South Curry Pike, Bloomington, Indiana 47403, Tebchaws Asmeskas (cartridge filling)

2. Sharp Corporation, USA 7451 Keebler Txoj Kev, Allentown, PA, 18106, USA Sharp Corporation, Tebchaws Asmeskas 7451 Keebler Txoj Kev, Allentown, Pennsylvania, 18106, Tebchaws USA (cartridge sib dhos hauv rab koob xaum xim)

PACKER (OB TXHAIS TES (COV NEEG) NTIM)

Enestia Belgium NV, Belgium
Kloknerstraat 1, Hamont-Ahel, B-3930,
Belgium Enestia Belgium NV, Belgium
Klocknerstraat 1, Hamont-Achel, B-3930, Belgium

TSWJ ZOO LICAS

AstraZeneca UK Luag, UK
Silk Road Business Park, Mcclesfield, Cheshire, SK10 2NA, UK
AstraZeneca UK Limited, United Kingdom brSilk Txoj Kev Lag Luam Chaw Ua Si, Macclesfield, Cheshire, SK10 2NA, United Kingdom

Lub npe, chaw nyob ntawm lub koom haum tso cai los ntawm tus tuav lossis tus tswv ntawm daim ntawv sau npe ntawm cov khoom lag luam rau kev kho mob kom lees txais kev thov los ntawm cov neeg siv khoom:

Sawv cev ntawm AstraZeneca UK Limited, United Kingdom,
hauv Moscow thiab AstraZeneca Cov Tshuaj LLC
125284 Moscow, st. Khiav, 3, p. 1

Baeta: cov lus qhia rau kev siv, nqi, xyuas, analogues

Ntshav qab zib mellitus yog ib yam mob uas pauv tau ntau tus neeg lub neej. Vim tias nws, koj yuav tsum tau ua raws li kev noj haus nruj thiab qoj ib ce, tab sis nws tshwm sim tias qhov no tsis txaus. Hauv cov xwm txheej zoo li no, xav tau kev pab kho mob. Baeta yog yeeb tshuaj tsim los ua kom cov ntshav qabzib hauv qib siab.

Sab sij huam

Xav txog cov kev mob tshwm sim thaum tuaj yeem siv tshuaj:

• Lub plab zom mov. Tsis tshua muaj qab los noj mov, muaj teeb meem nrog quav, ntuav, tsam plab hauv plab, muaj roj hauv cov hnyuv, pancreatitis.
• Kev zom zaub mov. Yog tias koj siv cov tshuaj ua ib feem ntawm kev sib xyaw ua ke nrog kev siv tshuaj insulin lossis metformin, ces kev mob ntshav qab zib tsawg tuaj yeem tshwm sim.
• Nruab nrab hauv lub paj hlwb. Kev co ntawm cov ntiv tes, zoo li tsis muaj zog thiab ua rau lub cev tsaug zog.
• Ua xua pob rau ntawm thaj chaw txhaj tshuaj. Xws li ua pob thiab o.
• Tsis hlauv.

Yog tias koj siv cov tshuaj rau ntev, tom qab ntawd cov tsos ntawm cov tshuaj tiv thaiv mus rau nws yog ua tau. Qhov no ua rau kev kho ntxiv rau tsis muaj nqi. Nws yog ib qho tsim nyog kom tso tseg cov tshuaj, hloov nws nrog ib qho zoo sib xws, thiab cov tshuaj tiv thaiv yuav ploj mus.

Baeta tsis muaj kev tiv thaiv kab mob. Kev kho mob rau cov kev mob tshwm sim nyob ntawm cov tsos mob.

Tus nqi yog nyob ntawm qhov ntau npaum:

• Rau kev daws teeb meem ntawm 1.2 ml yuav tau them 3990 rubles.
• Rau kev daws ntawm 2.4 ml - 7890 rubles.

Hauv cov khw muag tshuaj sib txawv, tus nqi hloov pauv. Yog li, piv txwv li, ib qho kev daws teeb meem ntawm 1.2 ml tau pom rau 5590 rubles, thiab 2.4 ml - 8570 rubles.

Xav txog qhov sib npaug ntawm Bayeta:

• Avandamet. Nws muaj cov khoom xyaw nquag metformin thiab rosiglitazone, uas sib txuam. Cov tshuaj pab tswj cov theem ntawm cov piam thaj hauv cov ntshav ncig, ua kom muaj kev cuam tshuam ntawm cov leeg ntawm pancreatic beta hlwb rau insulin. Muaj peev xwm yuav rau 2400 rubles.
• Arfazetin. Nws muaj cov nyhuv hypoglycemic. Pab txo cov piam thaj hauv qhov kev ua haujlwm hauv cov ntshav ncig. Nws tuaj yeem siv rau kev txhawb nqa, tab sis nws tsis tsim nyog rau kev kho kom zoo. Cov tshuaj muaj suab tsis muaj kev phiv thiab surpasses lwm analogues nyob rau hauv nqi. Nqe - 81 rubles.
• Bagomet. Muaj cov tshuaj yeeb dej caw uas muaj sia glibenclamide thiab metformin. Tsub kom cov ntaub so ntswg rhiab rau insulin. Txo cov roj cholesterol. Cov tshuaj tseem yuav pab cov tshuaj insulin zais. Muaj peev xwm yuav rau 332 rubles.
• Betanase Hauv kev kho mob nrog tus neeg sawv cev no, yuav tsum saib xyuas cov ntshav tas li. Cov tshuaj yog contraindicated nyob rau hauv cev xeeb tub thiab lactation. Nws tsis raug tso cai rau haus cawv thiab tshuaj muaj cawv nrog thaum kho. Nws yog ib qho nyuaj nrhiav nyob rau hauv cov khw muag tshuaj.
• Lub Neej. Ib qho tsis tshua muaj txiaj ntsig thiab muaj yeeb tshuaj zoo. Muaj cov tshuaj yeeb siv tshuaj zoo liraglutide. Cov neeg mob nce ntxiv insulin secretion, tab sis tsis yog glucagon. Liraglutide txo tus neeg mob lub siab. Muag rau hauv cov ntawv hauv kev txhaj tshuaj. Nqe - 9500 rub.
• Glibenclamide. Muaj cov tshuaj uas muaj cov kab mob glibenclamide. Txhim kho cov nyhuv ntawm cov tshuaj insulin rau cov suab thaj los ntawm cov leeg leeg. Cov tshuaj muaj qhov pheej hmoo tsawg kawg yog kev txhim kho hypoglycemia. Nws tuaj yeem raug siv ua ib feem ntawm kev kho ua ke. Muag rau 103 rubles.
• Glibomet. Muaj cov tshuaj metformin. Txhawb nqa insulin secretion. Siv tau cov tshuaj insulin. Cov tshuaj tsub ntxiv rau qhov sib txuas ntawm insulin nrog receptors, tsis muaj kev pheej hmoo ntawm kev mob hypoglycemia. Nqe - 352 rub.
• Gliclazide. Cov tshuaj yeeb tshuaj yog gliclazide. Tso cai rau koj kom lub cev theem ntawm qab zib hauv kev mob ntshav. Txo cov peev xwm ntawm vascular thrombosis, uas yog qhov zoo rau kev noj qab haus huv ntawm tus neeg mob. Nqe - 150 rubles.
• Metformin. Txhawb nqa gluconeogenesis. Cov tshuaj tsis pab txhawb kev ua haujlwm ntawm insulin, tab sis pauv nws qhov piv. Tso cai rau cov leeg mob kom nqus tau cov piam thaj zoo dua. Nqe - 231 rub.
• Januvius. Muaj cov sitagliptin. Siv rau kev kho mob monotherapy lossis kev sib txuas ua ke. Tsub cov insulin ntau zog, nrog rau cov rhiab ntawm pancreatic hlwb rau nws. Nqe - 1594 rubles.

Txoj kev zoo tshaj plaws los thov los ntawm txhua qhov analogues no? Nws nyob ntawm kev ntsuas ntawm tus neeg mob. Nws tsis raug tso cai kom hloov los ntawm ib qho yeeb tshuaj mus rau lwm tus ntawm koj tus kheej, ua ntej siv nws yog qhov yuav tsum tau sab laj tus kws tshaj lij.

Xav txog cov kev tshuaj xyuas uas tib neeg tawm txog cov tshuaj Bayeta:

Galina sau (https://med-otzyv.ru/lekarstva/144-b/35082-baeta #scomments) tias cov tshuaj tsis haum nws txhua: kev ntaus suab thaj thiab txhaj tshuaj tsis xis nyob kiag li. Tus poj niam tsuas hloov cov tshuaj, tom qab ntawd nws tus mob rov zoo li qub. Nws sau hais tias qhov tseem ceeb tshaj plaws yog kom muaj kev yoo mov noj.

Dmitry hais tias (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) uas nws tau siv tshuaj rau hauv lub xyoo tag nrho. Qab zib yog khaws cia hauv theem zoo, tab sis lub ntsiab, raws li tus txiv neej, yog qhov txo qis hauv lub cev hnyav los ntawm 28 kg. Ntawm cov kev mob tshwm sim, nws ua xeev siab. Dmitry hais tias qhov no yog yam tshuaj zoo.

Konstantin hais tias (https://med-otzyv.ru/lekarstva/144-b/35082-baeta#scomments) tias qhov tshuaj zoo, tab sis cov kev txhaj tshuaj tsis zoo txaus. Nws cia siab tias nws yuav muaj peev xwm nrhiav tau ib qho analogue ntawm cov tshuaj, muaj nyob hauv ntsiav tshuaj daim ntawv.

Kev txheeb xyuas hais tias cov tshuaj yuav pab tsis tau txhua tus. Ib qho ntawm nws cov teeb meem tseem ceeb yog daim ntawv ntawm kev tso tawm. Qhov no tsis yooj yim rau txhua tus neeg mob.

Baeta - ib qho tshuaj uas tso cai rau koj kom cov dej qab zib hauv cov kab mob mus ntev. Nws yog tus nqi kim heev, tab sis qee kis nws raug xaj cia dawb hauv tsev kho mob. Yog tias koj them sai sai rau kev tshuaj xyuas cov neeg mob, cov tshuaj yog deb ntawm kev siv thoob ntiaj teb.

Txuag lossis sib qhia: