Gluconorm - ib yam tshuaj rau ntshav qab zib hom 2

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj dawb puag ncig, convex ntawm ob sab. Cov chav kuaj mob yog ntim hauv cov hlwv ntim ntawm 10 daim ib qho. Lub thawv ntawv muaj 4 lub hlwv. Kuj tseem muaj pob nrog 2 hlwv ntawm 20 ntsiav tshuaj.

Gluconorm ntsiav tshuaj muaj cov tshuaj nquag:

• metformin hydrochloride - 400 mg,
• glibenclamide - 2.5 mg.

Txhawm rau nce bioavailability, qhov muaj pes tsawg leeg suav nrog cov khoom siv sib xyaw: gelatin, glycerol, diethyl phthalate, croscarmellose sodium, pob kws hmoov txhuv, lim talc, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.

Pharmacological kev txiav txim

Nws yog kev sib txuas ntawm cov tshuaj hypoglycemic los ntawm cov pawg kho mob heterogeneous: metformin thiab glibenclamide. Qhov tom kawg hais txog sulfonylurea derivatives ntawm lub cim thib ob. Nce qib ntawm cov piam thaj ntawm kev txhawb nqa ntawm pancreatic beta hlwb, ua rau muaj kev zais ntawm cov kua dej nyob rau qib thib ob. Stimulates insulin rhiab heev thiab qhov pib ntawm nws cov lus txhawb rau cov phiaj hlwb. Glibenclamide txhim kho kev nqus ntawm qab zib los ntawm cov leeg nqaij thiab lub siab, thaum tib lub sijhawm tiv thaiv kev cuam tshuam ntawm cov rog los ntawm lipase enzyme.

Metformin los ntawm cov pab pawg ntawm biguanides. Tsim los kom muaj qhov rhiab mob siab thiab txhim kho cov kua nplaum tawm los ntawm cov ntaub so ntswg peripheral. Cov tshuaj nquag yuav txo qis ntawm lipoproteins tsawg thiab triglycerides, muaj cov txiaj ntsig zoo ntawm lipid profile hauv cov ntshav. Tiv thaiv qhov tsim los ntawm cov plahaum rog plaques yam tsis muaj kev cuam tshuam ntawm lub cev hypoglycemic.

Glibenclamide

Tom qab kev tswj hwm ntawm qhov ncauj, adsorption ntawm glibenclamide hauv plab hnyuv me yog 50-85%. Cov tshuaj mus txog nws cov kev xav ntau hauv cov ntshav tom qab 1.5-2 teev. Nws khi rau cov protein ntau los ntawm 95%.

Glibenclamide yuav luag hloov pauv hauv daim siab nrog rau kev tsim ntawm ob lub cev ua kom tsis rog. Muaj cais cais tawm ntawm lub raum thiab lub plab zom mov. Ib nrab-lub neej nyob ntawm 3 txog 16 teev.

Thaum nws nkag rau hauv txoj hnyuv, qhov kev nqus tiav tshwm sim. Bioavailability ncav cuag 50-60%. Qhov nqus ntawm cov khoom txo qis nrog ib pluag mov. 30% ntawm metformin yog tawm hauv cov quav. Tus so tau sai sai faib thoob plaws cov ntaub so ntswg uas tsis khi rau cov protein ntshav.

Ib nrab-lub neej ncav 9-12 teev. Yuav luag tsis koom nrog hauv cov metabolism. Qhov tshem tawm ntawm metformin tawm hauv lub cev yog nqa los ntawm ob lub raum.

Gluconorm yog siv los ntawm cov neeg mob uas muaj ntshav qab zib hom 2:

• nrog rau kev ua tau zoo ntawm kev noj haus tsawg thiab kev tawm dag zog,
• nrog kev ua tsis tiav ntawm kev siv tshuaj metformin dhau los hauv cov neeg uas muaj kev tswj hwm qab zib ntau ntau.

Pom zoo siv rau cov neeg muaj hnub nyoog tshaj 18 xyoo.

Cov Yuav Tsum Muaj

Gluconorm yog txwv tsis pub siv:

• Kuv hom mob ntshav qab zib hom I
• cov poj niam thaum cev xeeb tub thiab lactation,
• nrog ib koob tshuaj miconazole,
• nyob rau hauv muaj mob lub raum khiav tsis zoo,
• cov neeg muaj suab thaj tsawg
• cov neeg mob porphyrin cuam tshuam los ntawm kev kis kab mob,
• nyob rau lub sijhawm postoperative thaum lub sijhawm phais mus kom tshem tawm cov roj ntawm thaj chaw loj,
• nrog lub siab thiab lub raum tsis ua haujlwm, nrog rau cov kev ua rau lawv (ua txhaum ntawm cov dej-ntsev tshuav, tso tawm sab nrauv, myocardial infarction thiab pulmonary tsis ua haujlwm),
• nrog tshuaj lom lub cev nrog co toxins,
• ob hnub ua ntej thiab tom qab radiography siv tus neeg sawv cev sib piv, uas suav nrog iodine,
• nrog mob lactic acidosis,
• raug rau cov zaub mov tsis muaj calorie ntau, uas ib tus neeg noj tsawg dua 1000 kcal / hnub,
• thaum muaj qhov tsis haum rau tshuaj metformin thiab cov khoom siv pabcuam.

Kev ceeb toom kuj tseem pom zoo thaum muaj kub taub hau, ua haujlwm tsis zoo thiab lub qog ntawm cov qog adrenal, nrog kev ua haujlwm tsis zoo ntawm anterior pituitary thiab lub qog caj pas.

Cov lus qhia rau kev siv (ntau npaum)

Gluconorm yog npaj rau kev tswj hwm qhov ncauj. Cov ntau npaum li cas ntawm cov tshuaj tau xaiv ib tus zuj zus los ntawm tus kws kho mob tuaj koom. Lub hauv paus rau kev teem caij ntawm cov neeg txhua hnub yog cov txiaj ntsig ntawm kev txheeb xyuas.

Thaum pib kho cov tshuaj, tus neeg mob tau teem 1 ntsiav tshuaj nyob rau ib hnub. Tom qab 7-14 hnub, qhov kev muab tshuaj ntawm cov tshuaj tau muab hloov kho raws li cov txiaj ntsig ntawm kev tshuaj ntsuam ntawm theem ntawm cov piam thaj hauv cov ntshav. Qhov siab tshaj plaws yuav tsum tsis pub tshaj 5 ntsiav tshuaj hauv ib hnub.

Thaum muaj kev hloov pauv ntawm kev sib xyaw ua ke yav dhau los ntawm metformin thiab glibenclamide, 1-2 ntsiav tshuaj ntawm Gluconorm tau sau tseg rau tus neeg mob, nyob ntawm qhov kev txhaj tshuaj yav dhau los ntawm txhua qhov.

Sab sij huam

Los ntawm ib sab ntawm cov roj metabolism cov pluas noj, tsis tshua muaj tshwm sim, ntshav qog ntshav qab zib.

Nrog kev phiv nyob rau txoj hnyuv thiab lub siab, tus neeg mob yuav hnov ​​xeev siab, ntuav, mob hauv thaj tsam epigastric, tsis qab los noj mov, “nws yog xim hlau” lub qhov ncauj. Hauv qee qhov teeb meem, daj ntseg yog pom tshwm sim, qhov kev ua haujlwm ntawm daim siab enzymes nce, kab mob siab.

Leukopenia, thrombocytopenia, erythrocytopenia, agranulocytosis, hemolytic lossis megaloblastic anemia, pancytopenia txhim kho thaum phiv los ntawm hematopoietic system yog manifested.

Lub hauv nruab nrab cov hlab ntsha tuaj yeem cuam tshuam nrog mob taub hau, kiv taub hau, qaug zog, thiab qaug zog. Muaj qee zaus, paresis, rhiab heev tsis hnov ​​qab.

Kev ua xua tau tshwm sim los ntawm kev ua kom mob dermatological:

• urticaria
• erythema
• khaus tawv
• npaws
• arthralgia
• tshuaj proteinuria.

Los ntawm ib sab ntawm cov metabolism, lactic acidosis yog ua tau.

Lwm yam: muaj kev cuam tshuam los ntawm dej cawv tsis txaus ntseeg tom qab haus dej, qhia los ntawm cov teeb meem ntawm cov ntshav ncig thiab ua pa ntawm lub cev (tsis xws li cov tshuaj tiv thaiv: ntuav, hnov ​​qhov kub ntawm lub ntsej muag thiab lub cev sab saud, tachycardia, kiv taub hau, mob taub hau).

Noj ntau dhau

Nrog kev noj haus ntau dhau ntawm cov tshuaj, cov tsos mob hauv qab no tshwm ua tiav:

• kev tshaib kev nqhis
• nce tawm hws,
• lub plawv dhia,
• tshee tshee qeeg tshee tshee hnyo.
• ntxhov siab vim thiab poob siab
• mob taub hau
• insomnia
• txob taus
• kev saib duab, qhov muag pom thiab lub cev hais tsis tau lus.

Yog tias tus neeg mob nco qab, qab zib yuav tsum ua. Hauv lub xeev tsis nco qab lawm, 1-2 ml ntawm glucagon los yog tso dej dextrose yuav tsum tau muab rau. Thaum rov qab paub meej, tus neeg mob yuav tsum noj zaub mov kom muaj zaub mov noj.

Vim tias muaj metformin hauv "Gluconorm", tus neeg mob yuav tsim muaj cov kab mob lactic acidosis. Tus mob no yuav tsum tau txais kev kho mob kub ntxhov thiab pw kho mob los ntawm hemodialysis.

Yeeb tshuaj sib cuam tshuam

Provoke nce kev txiav txim muaj peev xwm:

• allopurinol,
• lwm cov tshuaj hypoglycemic (biguanide pawg, insulin, acarbose),
• calcium tubule blockers,
• monoamine oxidase inhibitors
• coumarin anticoagulants,
• muaj ntsev,
• anabolic tshuaj yuam
• txhim kho sulfonamides,
• cyclophosphamide,
• tetracycline
• fenfluramine,
• fluoxetine
• pyridoxine
• guanethidine,
• pentoxifylline
• ACE inhibitors (enalapril, captopril),
• histamine H2 receptor blockers (cimetidine),
• antifungal (miconazole, fluconazole) thiab tshuaj tiv thaiv TB,
• chloramphenicol.

Glucocorticosteroids, barbiturates, antiepileptics (phenytoin), acetazolamide, thiazides, chlorthalidone, furosemide, triamterene, asparaginase, baclofen, danazol, diazoxide, Isoniazid, morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, thyroid hormones, lithium ntsev peev xwm ntawm ua kom tsis muaj zog ntawm cov tshuaj.

Cov tshuaj tiv thaiv, nicotinic acid, estrogens thiab chlorpromazine txo cov nyhuv tshuaj.

Vim tias qhov txo qis ntawm kev cuam tshuam thiab kev nce ntxiv reabsorption ntawm glibenclamide, ammonium chloride, calcium chloride, ascorbic acid (ntawm qhov siab kawg) txhim kho kev txiav txim ntawm cov tshuaj.

"Furosemide" nce qhov siab tshaj plaws ntawm metformin los ntawm 22%. "Nifedipine" txhim kho kev nqus, tab sis nws qhov kev xav ntau tshaj yuav ua rau tsis muaj qee yam ntawm cov tshuaj nquag.

Amyloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin los ntawm cationic kab kev sib ntaus rau tubular thauj cov tshuab, nrog kev siv lub sijhawm ntev ua rau kom cov concentration ntawm metformin los ntawm 60%.

Cov lus qhia tshwj xeeb

Kev tshem tawm yeeb tshuaj thiab hloov pauv nrog kev kho tshuaj insulin yog qhov yuav tsum tau ua rau qaug zog tom qab kev phais mob, raug mob, hlawv ntawm qhov chaw loj, ntxiv rau kis mob ntawm lub cev, nrog rau mob npaws.

Thaum lub sijhawm kho mob, yuav tsum tau saib xyuas cov piam thaj tas li.

Nrog rau kev yoo mov ntev ntev, nrog rau kev haus dej cawv, qhov kev pheej hmoo ntawm cov ntshav cov piam thaj nce ntxiv. Raws li kev tshawb nrhiav, thaum kho lub sijhawm, haus cawv tsis tso cai. Nrog rau kev tawm dag zog ntawm lub cev thiab ntawm lub siab lub siab, qhov ntau dua ntawm cov tshuaj tau hloov kho, kev noj haus hloov.

Ob hnub ua ntej kev phais mob lossis kev tswj hwm cov tshuaj iodine uas muaj cov tshuaj tiv thaiv hluav taws xob xav tau rau radiography, cov tshuaj tau raug muab tso tseg. Rov qab pib dua 48 teev tom qab kev tshawb fawb.

Thaum lub sijhawm kho, nws yog ib qho tsim nyog yuav tsum tsis kam ua los ntawm ntau yam haujlwm uas yuav tsum muaj kev xav thiab nce siab ntawm lub cev muaj zog. Tsis pub tsav tsheb.

Cev xeeb tub thiab lactation

Cov tshuaj tsis pub txwv rau siv thaum cev xeeb tub. Rau lub sij hawm ntawm kev npaj thiab kev coj tus kheej, nws raug tso tseg. Gluconorm hloov kho insulin.

Cov poj niam thaum lub sijhawm lactation tseem raug txwv tsis pub noj tshuaj vim tias nkag mus ntawm metformin rau hauv niam cov kua mis. Cov niam yuav tsum pauv mus kho mob insulin. Yog tias qhov kev ua no tsis tuaj yeem ua tiav, tsum tsis txhob pub mis.

Piv nrog analogues

TSEEM CEEB! Nws yog nruj me ntsis txwv tsis pub nqa tawm ib qho kev hloov ywj siab ntawm Gluconorm nrog lwm yam tshuaj tsis muaj kev sab laj nrog kws kho mob.

1. Glibomet. Muaj cov tshuaj zoo ib yam: metformin thiab glibenclamide. Thaum noj tshuaj, cov qog cov tshuaj hormones los ntawm cov hlwb ntawm cov txiav ua kom zoo dua qub ntxiv thiab muaj qhov cuam tshuam ntawm cov ntaub so ntswg mus rau kev ua ntawm insulin nce.

Tab sis tsis zoo li Gluconorm, cim qhia rau kev siv txawv:

• "Glibomet" yog siv thaum lub cev tiv thaiv sulfonylurea derivatives vim siv sijhawm ntev,
• muaj ib hom mob ntshav qab zib insulin-ywj pheej.

Lub sijhawm kho thiab qhov niaj hnub ntawm "Glibomet" tsis yog nyob ntawm kev saib xyuas cov piam thaj hauv cov ntshav nkaus xwb, tab sis kuj nyob ntawm lub xeev ntawm tus neeg mob lub cev metabolism.

Qhov txawv kuj ua tau nws tus kheej hauv qee qhov kev mob tshwm sim:

• ib qho poob hauv cov qe ntshav dawb,
• kev ua xua tshwm sim raws li cov tawv nqaij ua xua (khaus, liab),
• Cov tshuaj zoo tagnrho yog xaiv nrog kev soj ntsuam tas li ntawm tus neeg mob.

Tus nqi yog 90-100 rubles siab dua.

Metglib. Cov muaj pes tsawg leeg zoo sib xws. Qhov sib txawv yog nyob rau hauv cov muaj pes tsawg leeg ntawm kev ua si, uas ua rau kev ncua ntawm kev nqus ntawm cov piam thaj hauv cov hnyuv me, thiab tseem yuav tiv thaiv gluconeogenesis thiab glycogenolysis hauv lub siab.

"Metglib" txo tus neeg mob lub cev qhov hnyav los ntawm kev tiv thaiv kev tsim cov roj cholesterol thiab lipoproteins uas tsis muaj ntau. Nws yog txwv tsis pub noj cov tshuaj nrog Bozentan vim qhov pheej hmoo ntawm hepatic intoxication.

Tus nqi them yog tsis qis dua rau Gluconorm.

Pharmacodynamics thiab pharmacokinetics

Gluconorm muaj kev sib koom ua ke ntawm ob qhov hypoglycemic tshuaj sib txawv rau ntau pawg pharmacological: metforminthiab glibenclamide.

Nyob rau tib lub sijhawm, metformin yog biguanide muaj peev xwm txo qis dua ntawm cov piam thaj hauv kev sib xyaw ua ke ntawm cov ntshav dej ntshavCov. Qhov no yog ua tiav los ntawm kev ua kom tau qhov nkag siab ntawm cov ntaub so ntswg txuas nrog insulin qhov kev txiav txim siab thiab txhim kho kev ntes piam thaj. Tsis tas li, qhov kev nqus ntawm cov carbohydrates los ntawm cov hnyuv poob zuj zus thiab muaj kev cuam tshuam gluconeogenesis hauv lub siab. Qhov txiaj ntsig zoo ntawm cov tshuaj, tsom rau lipid lub xeev ntawm cov ntshav, tau sau tseg, cov ntsuas ntawm qhov dav dav roj thiabtriglycerides. Kev ua kom lub cev tsis ntshav qab zib tsis tshwm sim.

Glibenclamide yog 2 tiam sulfonylurea derivative. Qhov kev tivthaiv no yog qhia los ntawm kev ua kom muaj zog ntawm insulin secretion vim qhov txo qis ntawm cov nyhuv ua rau cov kua nplaum hauv lub hlwb, kev rhiab rau insulin nce ntxiv, nrog rau qhov kev sib txuas ntawm nws cov kev sib txuas nrog cov phiaj hlwb. Tsis tas li ntawd, qhov kev tso tawm ntawm cov kua dej nce ntxiv, cov nyhuv ntawm insulin rau ntawm cov txheej txheem ntawm cov piam thaj los ntawm cov leeg nqaij thiab lub siab ua kom muaj zog, thiab lipolysis hauv adipose cov ntaub so ntswg yog inhibited. Qhov kev nqis tes ntawm cov tshuaj no tau raug nthuav tawm hauv qib 2 ntawm kev zais tshuaj insulin

Cov tshuaj yog zoo nqus los ntawm lub plab zom mov. Qhov siab tshaj plaws tau tiav hauv 1.5 teev. Raws li qhov tshwm sim metabolism hauv ob peb metabolitesCov. Cov tshuaj no tau tawm ntawm lub cev nrog kev pab ntawm lub raum thiab hnyuv.

Kev ntsuas rau siv

Gluconorm daim ntawv thov yog tshuaj rau ntshav qab zib hom 2 rau cov neeg mob laus nrog:

• kev ua tsis tau zoo ntawm kev noj zaub mov noj, ua kom lub cev dhau los thiab kev kho mob dhau los nrog glibenclamide lossis metformin,
• qhov yuav tsum tau hloov cov kev kho mob dhau los nrog cov tshuaj no rau cov neeg mob uas muaj ntshav khov thiab tswj ntshav qabzib.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv txiav tshuaj - cov yeeb yaj kiab-cov ntsiav tshuaj: puag ncig, convex ntawm ob sab, yuav luag dawb lossis dawb, ntawm qhov tawg - ntawm dawb mus dawb-greyish hauv xim (10 pcs hauv ib lub hlwv, 4 lub hlwv hauv ib lub thawv ntawv, 20 pcs hauv ib lub hlwv , 2 lub hlwv hauv pob ntawv qhwv).

Yam tshuaj muaj nyob hauv 1 ntsiav tshuaj:

• metformin hydrochloride - 400 mg,
• glibenclamide - 2.5 mg.

Cov khoom siv ntxiv: diethyl phthalate, croscarmellose sodium, glycerol, gelatin, pob kws hmoov txhuv, cellulosefate, huv si talc, colloidal silicon dioxide, sodium carboxymethyl hmoov txhuv nplej siab, microcrystalline cellulose, magnesium stearate.

Sab sij huam

Thaum noj Gluconorm, cov kev mob tshwm sim tuaj yeem tsim kev cuam tshuam cov metabolism hauv kev ua kom rog, daim siab thiab lub plab ua haujlwm, kev tsim cov ntshav thiab cov leeg ntshav. Qhov no tuaj yeem nrog: hypoglycemia, lactic acidosis, xeev siab, ntuav, mob plab, poob qab los, leukopenia, thrombocytopenia, erythrocytopenia, mob taub hau, kiv taub hautsis muaj zog, ua haujlwm hnyav thiab lwm yam.

Gluconorm, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Cov tshuaj no yog npaj rau cov thawj coj hauv qhov ncauj tib lub sijhawm ua zaub mov. Hauv qhov no, ntau npaum li cas ntawm cov tshuaj tau tsim los ntawm tus kws kho mob, coj mus rau hauv tus account tus yam ntxwv ntawm txhua tus neeg mob raws qib uas cov piam thaj hauv cov ntshav.

Raws li txoj cai, kev kho mob pib nrog kev noj tshuaj txhua hnub - 1 ntsiav tshuaj. Txhua 2 lub lis piam, cov tshuaj raug muab kho raws qib uas cov piam thaj hauv cov ntshav. Thaum hloov cov kev kho mob yav dhau los nrog metformin thiab glybeklamide ua tau, 1-2 ntsiav tshuaj yog kho rau cov neeg mob. Hauv qhov no, kev noj tshuaj txhua hnub tsis tuaj yeem muaj ntau dua 5 ntsiav tshuaj.

Kev taw qhia rau kev teem caij gluconorm

Hauv ntau tus neeg mob ntshav qab zib mellitus, ib qho tshuaj tsis tuaj yeem ruaj khov kho cov piam thaj li qub, yog li cov kws kho mob feem ntau nyiam siv tshuaj kho kom haum. Qhov ntsuas rau nws kev teem caij yog glycated hemoglobin saum toj no 6.5-7%.Qhov tseem ceeb tshaj plaws xav txog kev sib txuas ua ke ntawm metformin nrog sulfonylurea derivatives (PSM), gliptins thiab incretin mimetics. Tag nrho cov kev sib txuas ua ke cuam tshuam ob qho tag nrho cov tshuaj insulin thiab insulin ntau lawm ntim tam sim ntawd, yog li ntawd lawv muab cov txiaj ntsig zoo tshaj plaws.

Kev sib xyaw ua ke ntawm metformin + sulfonylurea yog qhov muaj ntau tshaj plaws. Cov khoom sib txuam tsis muaj peev xwm sib cuam tshuam nrog ib leeg, tsis txo qis kev ua tau zoo. Glibenclamide yog qhov muaj zog tshaj plaws thiab kawm ntawm txhua PSM. Nws muaj tus nqi qis thiab raug muag hauv txhua lub tsev muag tshuaj, yog li ntawd, ua ke nrog metformin, glibenclamide tau sau tseg yuav luag zoo dua li lwm yam tshuaj. Txhawm rau siv yooj yim, ob lub tshuaj tiv thaiv tau tsim nrog ob cov khoom xyaw nquag no - Gluconorm thiab nws cov analogues.

Raws li cov lus qhia, Gluconorm tsuas yog siv tshwj xeeb rau kev mob ntshav qab zib hom 2, yog kev txhim kho kev noj haus, kev ua kis las, thiab metformin tsis tso ntshav qabzib mus rau qhov tseem ceeb. Cov koob tshuaj ntawm cov tshuaj metformin yuav tsum tsis pub tsawg dua (2000 mg) lossis ib txwm zam rau cov kab mob ntshav qab zib. Kuj, gluconorm tuaj yeem noj los ntawm cov neeg mob uas yav dhau los haus dej haus glibenclamide thiab metformin cais.

Tshawb nrhiav pom: cov ntsiav tshuaj tsawg dua uas tus neeg mob tau noj ib hnub, nws ntau dua nws xav ua raws li txhua tus kws kho mob cov ntawv sau, uas txhais tau tias qhov ua tau zoo dua ntawm kev kho mob. Ntawd yog, kev noj tshuaj Gluconorm hloov ntawm ob ntsiav tshuaj yog ib kauj ruam me me rau kev them nyiaj zoo dua rau ntshav qab zib.

Tsis tas li ntawd, qhov kev nce qib ob zaug ntawm cov tshuaj ntawm cov piam thaj-txo cov ntsiav tshuaj tsis muab rau kev txo qis hauv qab zib. Ntawd yog, ob lub tshuaj hauv ib qho tshuaj me me yuav ua haujlwm ntau dua thiab muab cov kev mob tshwm sim tsawg dua li ib qho tshuaj hauv qhov ntau kawg.

Cov tshuaj sib xyaw thiab cuam tshuam ntawm cov tshuaj

Gluconorm yog tsim los ntawm Lavxias lub tuam txhab Pharmstandard hauv kev koom tes nrog Indian Biopharm. Cov tshuaj muaj nyob rau hauv 2 version:

1. Gluconorm ntsiav tshuaj yog tsim hauv Is Nrias teb, ntim hauv tebchaws Russia. Cov tshuaj muaj cov tshuaj qub ntawm 2.5-400, uas yog, txhua ntsiav tshuaj ntawm metformin muaj 400 mg, glibenclamide 2.5 mg.
2. Gluconorm Plus ntsiav tshuaj yog tsim nyob rau hauv Russia los ntawm cov tshuaj lag luam yuav khoom hauv Is Nrias teb thiab Tuam Tshoj. Lawv muaj 2 koob tshuaj: 2.5-500 rau cov neeg mob ntshav qab zib uas muaj qhov muaj peev xwm tiv thaiv insulin ntau dua thiab 5-500 rau cov neeg mob uas tsis muaj qhov hnyav dhau, tab sis nrog qhov tsis txaus insulin.

Ua tsaug rau ntau txoj kev xaiv ntau npaum li cas, koj tuaj yeem xaiv txoj kev sib piv rau txhua tus neeg mob ntshav qab zib hom 2.

Cia peb xav txog nyob rau hauv ntau dua yuav ua li cas lub Cheebtsam ntawm cov tshuaj Gluconorm ua hauj lwm. Metformin txo ob qho kev ua haujlwm tom qab thiab yoo mov glycemia feem ntau vim yog qhov txo qis hauv insulin tsis kam. Cov piam thaj tawm cov hlab ntsha sai dua, vim cov ntaub so ntswg hloov pauv nrog cov kua dej. Metformin kuj tseem txo cov kev tsim cov piam thaj hauv lub cev los ntawm cov khoom uas tsis yog carbohydrate, maj mam nkag mus rau hauv cov ntshav los ntawm cov hnyuv.

Txog rau cov ntshav qab zib, ntxiv cov yeeb yam ntawm metformin uas tsis cuam tshuam nrog kev txo qis hauv glycemia kuj tseem ceeb heev. Cov tshuaj tiv thaiv kev loj hlob ntawm angiopathy los ntawm normalizing ntshav lipids, txhim kho cov zaub mov noj nqaij. Raws li qee qhov lus ceeb toom, metformin tuaj yeem tiv thaiv qhov pom ntawm neoplasms. Raws li cov neeg mob, nws txo qis kev qab los noj mov, pab tswj lub cev kom zoo, pab txhawb lub cev yuag, thiab nce kev ua kom yuag.

Glibenclamide yog PSM 2 tiam. Nws ua haujlwm ncaj qha rau pancreatic beta hlwb: nws txo qis ntawm qhov pib ntawm lawv qhov rhiab heev rau cov piam thaj hauv ntshav, thiaj li ua cov insulin ntau ntxiv. Glibenclamide tseem tuaj yeem txhim kho glycogenogenesis - txheej txheem ntawm khaws cov piam thaj hauv cov leeg thiab nplooj siab. Tsis zoo li metformin, cov tshuaj no tuaj yeem ua rau mob ntshav qab zib, hnyav dua lwm yam neeg sawv cev ntawm pawg PSM - glimepiride thiab glyclazide. Glibenclamide suav hais tias yog qhov muaj zog tshaj plaws, tab sis kuj tseem muaj kev phom sij ntawm PSM. Nws tsis pom zoo rau cov neeg mob ntshav qab zib nrog qhov kev pheej hmoo ntawm kev mob ntshav qab zib.

Yuav noj tshuaj Gluconorm li cas

Cov kev mob tshwm sim feem ntau ntawm metformin yog kev zom, glibenclamide - mob ntshav qab zib. Koj tuaj yeem txo cov kev pheej hmoo tsis zoo ntawm kev kho nrog gluconorm, noj tshuaj rau tib lub sijhawm ua zaub mov thiab maj mam nce koob tshuaj, pib nrog qhov tsawg kawg nkaus.

Dosage ntawm yeeb tshuaj Gluconorm raws li cov lus qhia:

Nrog muaj zog insulin tsis kam, uas yog cov yam ntxwv ntawm cov neeg rog nrog ntshav qab zib, metformin ntxiv yuav raug tshuaj. Feem ntau hauv qhov no lawv haus nws ua ntej mus pw. Qhov zoo tshaj plaws txhua hnub koob tshuaj metformin raug txiav txim siab yog 2000 mg, qhov siab tshaj - 3000 mg. Ib txoj kev nce ntxiv hauv cov tshuaj yog qhov txaus ntshai nrog cov kab mob lactic acidosis.

Muaj qhov tsis muaj cov carbohydrates hauv cov zaub mov, Gluconorm ua rau lub cev tsis muaj ntshav qab zib. Txhawm rau tiv thaiv nws, cov ntsiav tshuaj yog qaug cawv nrog cov zaub mov tseem ceeb. Cov khoom lag luam yuav tsum muaj cov carbohydrates, feem ntau qeeb. Koj tuaj yeem tsis cia ncua sijhawm ntev nruab nrab ntawm pluas noj, yog li cov neeg mob tau pom zoo kom noj khoom txom ncauj ntxiv. Kev soj ntsuam cov ntshav qab zib qhia tau hais tias nrog kev tawm dag zog lub cev, qab zib tuaj yeem poob rau ob peb feeb xwb. Lub sijhawm no, koj yuav tsum tau ua tib zoo saib xyuas koj txoj kev noj qab haus huv.

Kev sib piv thiab hloov chaw

Ua kom tiav cov tshuaj analogues, ntxiv rau metformin thiab glibenclamide cais, tuaj yeem ua kom tsis muaj teeb meem hauv kev noj haus tib yam li Gluconorm. Yog tias koj npaj siab yuav hloov mus rau kev kho mob nrog lwm tus sulfonylurea derivative, koob tshuaj yuav tau rov xaiv duaCov. Cov kws kho mob pom zoo kom hloov ntawm Gluconorm mus rau Amaryl lossis Glimecomb rau cov neeg mob ntshav qab zib nrog hom 2 carbohydrate cuam tshuam, uas feem ntau ntsib kev mob hypoglycemia.

Raws li kev txheeb xyuas, cov txiaj ntsig ntawm Gluconorm thiab nws cov analogues zoo li ze, tab sis cov neeg mob ntshav qab zib tseem xav siv German Glybomet, suav tias nws yog cov tshuaj zoo tshaj.

Kev cai cia thiab nqe

Gluconorm siv tau rau 3 xyoos txij li hnub ntau lawm. Gluconorm Plus pub rau muab tsis pub tshaj 2 xyoos. Cov lus qhia tsis muaj cov kev cai tshwj xeeb rau kev cia khoom, nws yog qhov txaus los soj ntsuam ib lub koomhaum ua kom sov tsis pub dhau 25 degrees.

Cov neeg mob ntshav qab zib hauv Lavxias tuaj yeem tau txais ob qho tshuaj raws li cov tshuaj noj dawb los ntawm kws kho mob lossis kws kuaj mob endocrinologist. Kev yuav ntawm tus kheej yuav raug nqi pheej yig: tus nqi ntawm ib pob ntawm 40 ntsiav tshuaj ntawm Gluconorm yog txog 230 rubles, Gluconorm Plus tus nqi ntawm 155 txog 215 rubles. rau 30 ntsiav tshuaj. Rau kev sib piv, tus nqi ntawm thawj Glibomet yog li 320 rubles.

Nco ntsoov kawm! Koj puas xav tias kev tswj hwm kev noj qab haus huv ntawm cov tshuaj thiab cov kua dej yog ib txoj kev los tswj cov piam thaj kom tswj? Tsis muaj tseeb! Koj tuaj yeem soj ntsuam qhov no koj tus kheej los ntawm kev pib siv nws. nyeem ntxiv >>

Daim ntawv thov nta

Nws yog ib qho tsim nyog yuav tsum tshem tawm kev kho mob nrog rau cov tshuaj rau kis kab mob nrog kev kub taub hau, nrog kev raug mob loj thiab kev cuam tshuam kev phais. Txoj kev pheej hmoo ntawm kev txo qis cov ntshav qab zib thaum lub sij hawm tshaib plab, kev siv cov NSAIDs, ethanol yog nce ntxiv. Dosage kev kho kom haum yog nqa tawm thaum hloov pauv kev noj haus, ua kom lub cev muaj zog thiab lub dag lub zog dhau los.

Cov lus qhia Gluconorm piav qhia tias nws tsis pom zoo kom haus dej cawv thaum kho. Cov tshuaj ntsiav tuaj yeem cuam tshuam qhov ceev ntawm psychomotor kev ua haujlwm thiab txo qis. Yog li, koj yuav tsum ceev faj thaum tsav tsheb tsim kev phom sij thiab tsheb.

Nws yog txwv tsis pub noj tshuaj thaum yau, thaum cev xeeb tub, thaum pub niam mis, vim tias lub hauv paus tseem ceeb nkag mus rau niam lub mis. Cov tshuaj yog contraindicated nyob rau hauv cov neeg nrog pathologies ntawm ob lub raum thiab mob siab. Kev siv cov ntsiav tshuaj hauv cov neeg laus yog tsis pom zoo nrog kev ua kom lub cev hnyav.

Kev cuam tshuam nrog lwm yam tshuaj

Ua ntej pib txoj kev kho mob, koj yuav tsum paub txog yuav ua li cas Gluconorm cuam tshuam nrog lwm yam tshuaj:

• txhim kho cov cuab yeej hypoglycemic: ACE inhibitors, MAO, NSAIDs, fibrates, allopurinol, anabolic steroids, tiv thaiv kab mob TB, tshuaj tiv thaiv kab mob acidifying ntsiav tshuaj,
• cov nyhuv ua kom tsis muaj zog: tshuaj tiv thaiv qog, tshuaj tiv thaiv iodine muaj cov thyroid hormones, barbiturates, adrenostimulants, corticosteroids, muaj zog ntau ntawm nicotinic acid, glucagon, furosemide, thiazide diuretics, tshuaj tiv thaiv kab mob,
• nce qib ntawm metformin: cationic tshuaj, furosemide,
• nce ntxiv furosemide qib: metformin,
• ncua kev tshem tawm ntawm cov tshuaj metformin: nifedipine.

Tsuas tshuaj thiab tswj hwm

Gluconorm yog qhia rau kev siv qhov ncauj. Cov ntsiav tshuaj yuav tsum noj nrog zaub mov.

Cov koob tshuaj txaus rau txhua tus neeg mob tau xaiv ib tus zuj zus raws li cov ntaub ntawv hais txog theem ntawm cov piam thaj hauv cov ntshav.

Qhov kev muab tshuaj thawj zaug feem ntau yog 1 ntsiav tshuaj 1 zaug hauv ib hnub. Yog tias tsim nyog, nce qhov koob tshuaj txhua 1-2 lub lis piam kom txog thaum pom cov txiaj ntsig tiav.

Nyob rau hauv kev tswj hwm ntawm Gluconorm es tsis txhob sib xyaw ntawm ob yam tshuaj - metformin thiab glibenclamide - koob tshuaj yog txiav txim siab nyob ntawm cov koob tshuaj uas dhau los ntawm txhua feem, feem ntau 1-2 ntsiav tshuaj tau sau tseg.

Qhov siab tshaj plaws pub siv tau yog 5 ntsiav tshuaj rau ib hnub.

Cov ntaub ntawv dav dav, muaj pes tsawg leeg thiab cov ntawv tso tawm

Gluconorm yog hypoglycemic tshuaj nyob hauv Is Nrias teb. Ntxiv rau qhov ua kom lub suab thaj txo qis, cov tshuaj pab ua rau qhov qis qis ntawm cov roj cholesterol nyob hauv cov ntshav ntawm tus neeg mob.

Nws raug tso cai kom faib nyiaj raws li cov ntawv xaj ntawm tus kws tshaj lij tuaj koom. Cov tshuaj yeeb yaj kiab tau siv rau 3 xyoos txij li hnub ntawm nws cov chaw tsim khoom.

Nws yog ib qho tsim nyog yuav tau soj ntsuam qhov chaw cia khoom ntawm cov tshuaj no. Nws muab khaws cia rau hauv qhov chaw tsaus tsis muaj menyuam nkag. Qhov zoo tshaj plaws cia cia kub yog 20-23 0 C.

Tsis tas li ntawd, Gluconorm nrog blueberries nyob rau hauv daim ntawv ntawm cov tshuaj ntsuab tshuaj ntsuab yog tsim, uas tsis yog tshuaj, tab sis yog noj raws li cov piam thaj hauv dej qab zib.

Ntawm lwm yam tshuaj ntawm cov tshuaj, sodium carboxymethyl hmoov txhuv nplej siab, magnesium stearate thiab cellacephate tau sau tseg. Hauv qee qhov ntau, talc nrog pob kws hmoov txhuv nplej thiab gelatin muaj nyob rau hauv qhov muaj pes tsawg leeg tshuaj.

Ib pob tshuaj muaj pob 1-4 lub hlwv. Sab hauv lub hlwv tuaj yeem yog 10, 20, 30 ntsiav tshuaj ntawm cov tshuaj. Cov ntsiav tshuaj ntawm cov tshuaj yog dawb thiab muaj daim biconvex puag ncig. Thaum lub sijhawm so, cov ntsiav tshuaj yuav muaj me ntsis greyish zas.

Gluconorm blueberry tshuaj yej tsis muaj qhov feem cuam hauv cov ntsiav tshuaj. Nws yog tsim los ntawm cov tshuaj ntsuab thiab muag hauv cov qauv ntawm cov hnab ntim tshuaj yej. Lub chav kawm ntawm kev pub nkag yog tsim rau 3 lub lis piam.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Gluconorm muaj ob lub ntsiab: Glibenclamide thiab Metformin. Ob qho tshuaj yeeb dej caw ua rau kev sib koom ua ke, nce qhov kev ua tau zoo ntawm cov tshuaj.

Glibenclamide yog 2 tiam sulfonylurea derivative. Vim nws qhov kev txiav txim, insulin secretion yog tsa, thiab kuj tseem yuav muaj cov tshuaj insulin ua rau muaj cov hlwb tseem ceeb ntau ntxiv.

Glibenclamide txhawb nqa lub zog tso tawm ntawm insulin thiab txhim kho nws cov nyhuv ntawm kev nqus ntawm cov piam thaj los ntawm lub siab, ua rau cov leeg muaj zog. Hauv qab qhov kev txiav txim ntawm cov quav yeeb tshuaj, cov txheej txheem ntawm kev sib cais cov rog hauv cov ntaub so ntswg adipose qeeb qeeb.

Metformin yog cov khoom siv loj loj. Vim tias qhov kev nqis tes ua no, cov ntsiab lus ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob tau raug txo qis, muaj kev nce ntxiv ntawm cov piam thaj los ntawm cov ntaub so ntswg.

Cov tshuaj yog zoo rau txo qis hauv kev suav hauv cov roj (cholesterol) hauv cov ntshav. Vim tias kev ua ntawm Metformin, qhov nqus ntawm cov carbohydrates hauv lub plab thiab cov hnyuv poob qis. Cov tshuaj pom tau inhibits qhov tsim ntawm muaj piam thaj hauv lub siab.

Glibenclamide thiab Metformin, uas yog ib feem ntawm qhov tshuaj, muaj cov tshuaj txawv txawv.

Qhov nqus ntawm glibenclamide tom qab kev noj haus ntawm lub plab thiab cov hnyuv nce mus txog 84%. Qhov siab tshaj plaws ntawm ib qho khoom tuaj yeem mus txog hauv ib teev lossis ob teev. Cov tshuaj yog zoo txuam nrog cov ntshav protein. Tus nqi ntsuas yog 95%. Qhov tsawg kawg nkaus ib nrab-lub neej yog 3 teev, qhov siab tshaj yog 16 teev. Cov tshuaj yog qee tawm ntawm lub raum, ib feem los ntawm txoj hnyuv.

Qhov siab tshaj plaws ntawm lub cev ntawm Metformin tsis yog ntau tshaj 60%. Noj ua rau qeeb qeeb dua qhov nqus ntawm metformin. Cov tshuaj tawm ntawm lub plab tas yog nqus tau los ntawm lub plab thiab txoj hnyuv.

Tsis zoo li Glibenclamide, nws muaj kev pheej hmoo qis nrog cov ntshav protein. Nws yog tawm los ntawm lub raum. 30% ntawm cov tshuaj yuav tuaj yeem nyob hauv tus neeg mob quav. Qhov kev tshem tawm ib nrab-lub neej mus txog 12 teev.

Kev taw qhia thiab contraindications

Qhov qhia tseem ceeb rau kev noj cov tshuaj no yog qhov muaj tus mob ntshav qab zib hom II hauv tus neeg mob. Tsis tas li, cov tshuaj tau raug sau tseg thaum tsis muaj txiaj ntsig ntawm kev kho mob nrog rau kev noj zaub mov zoo, kev tawm dag zog thiab kev kho mob raws li kev noj cov tshuaj Metformin nrog Glibenclamide.

Cov tshuaj tseem yog qhia rau cov neeg mob uas muaj ntshav qab zib thiab cov ntshav qab zib kom ruaj khov, tab sis tus uas xav tau hloov los kho nrog Glibenclamide thiab Metformin.

Ib tug tseem ceeb tus naj npawb ntawm contraindications yog cov yam ntxwv ntawm cov tshuaj:

• daim siab ua hauj lwm
• cov piam thaj hauv ntshav tsawg (hypoglycemia),
• siab rhiab heev rau cov tshuaj ntawm cov tshuaj,
• yam kuv mob ntshav qab zib
• haus cawv ntev,
• cev xeeb tub
• lub raum tsis ua haujlwm vim muaj kab mob, poob siab,
• ketoacidosis
• siv ntawm miconazole,
• muaj kev hlawv ntawm lub cev,
• lub plawv tsis ua hauj lwm
• pub niam mis
• ntau yam kab mob
• mob ntshav qab zib coma
• lub raum tsis ua hauj lwm
• myocardial infarction
• kev pab cuam phais mob
• lactic acidosis,
• haus dej cawv lom
• ua pa tsis ua hauj lwm
• kuaj mob ntshav qab zib
• Kab mob porphyrin.

Cov Neeg Mob Tshwj Xeeb thiab Cov Lus Qhia

Cov tshuaj no yog txwv rau tus poj niam cev xeeb tub. Nws kuj tseem tsis lees txais cov tshuaj hauv cov txheej txheem ntawm kev npaj cev xeeb tub.

Gluconorm yuav tsum tsis txhob noj lactating poj niam, txij li Metformin nquag nkag rau niam mis thiab tuaj yeem cuam tshuam loj rau kev noj qab haus huv ntawm tus menyuam mos. Hauv cov rooj plaub no, kev hloov pauv cov tshuaj nrog kev kho mob insulin yog kev pom zoo.

Cov tshuaj tsis pom zoo rau cov neeg laus laus uas lawv hnub nyoog tshaj 60 xyoo. Ua ke nrog kev hnyav, Gluconorm tuaj yeem ua rau lactic acidosis hauv pawg neeg no.

Cov tshuaj yuav tsum ua tib zoo saib xyuas los ntawm cov neeg mob kev txom nyem los ntawm:

• adrenal tsis txaus,
• npaws
• cov thyroid kab mob.

Txog tshuaj, ntau cov lus qhia tshwj xeeb yog muab:

• thaum kho, yuav tsum saib xyuas cov ntshav qabzib nyob ntawm lub plab thiab tomqab noj mov tas,
• txwv tsis pub noj tshuaj thiab haus dej caw,
• nws yog ib qho tsim nyog los hloov cov tshuaj nrog kev kho mob insulin yog tias tus neeg mob tau raug mob, kis mob, kub taub hau, kub hnyiab, ua haujlwm dhau los,
• 2 hnub ua ntej kev qhia ntawm cov tshuaj radiopaque uas muaj iodine mus rau hauv tus neeg mob lub cev, nws yog qhov yuav tsum tau tsum tsis txhob noj cov tshuaj (tom qab 2 hnub, kev pib ua haujlwm yuav rov pib dua),
• kev sib koom tes ntawm Gluconorm nrog ethanol provokes hypoglycemia, nws kuj tshwm sim thaum yoo mov thiab noj cov tshuaj tiv thaiv kev tiv thaiv ntawm ib hom tshuaj tsis-tshuaj,
• cov tshuaj cuam tshuam rau tus neeg mob lub peev xwm los tsav lub tsheb (koj yuav tsum tsis kam tsav tsheb thaum tsav tsheb nrog tshuaj)

Tus neeg mob lub tswv yim

Ntau cov kev ntsuam xyuas ntawm tus neeg mob ntshav qab zib txog cov tshuaj Gluconorm muaj feem cuam tshuam zoo rau kev noj tshuaj, txawm li cas los xij, cov kev mob tshwm sim tau hais tseg, ntawm cov uas xeev siab thiab mob taub hau feem ntau tau ntsib, uas tau raug tshem tawm los ntawm kev kho kom haum.

Cov tshuaj yog qhov zoo, nws txo qis suab thaj zoo. Kuj ceeb tias, Kuv tsis pom qhov kev mob tshwm sim uas feem ntau tau sau txog. Tus nqi pheej yig heev. Kuv yuam Gluconorm ntawm kev txuas ntxiv mus.

Kuv tau raug tus mob ntshav qab zib hom 2 tau ntau xyoo. Tus kws kho mob mus koom kws kho mob hais tias pom tus mob Gluconorm. Thaum xub thawj, muaj cov kev mob tshwm sim: feem ntau muaj mob, muaj kiv taub hau. Tab sis yav tom ntej peb tau kho qhov koob tshuaj, thiab txhua yam dhau. Cov cuab yeej siv tau zoo yog tias koj sib xyaw ua ke nws nrog kev noj haus.

Gluconorm yog ntseeg tau tag nrho. Hauv kuv qhov xwm txheej, Kuv pab kho ntxiv qhov hnyav. Cov tshuaj txo cov qab los noj mov. Ntawm cov minuses, Kuv yuav hais txog phiv phiv. Muaj ntau ntawm lawv. Ib lub sij hawm, kuv taub hau mob thiab mob heev.

Tsis ntev dhau los, tus endocrinologist tau ua qhov kev kuaj mob tsis txaus siab - hom ntshav qab zib 2. Gluconorm tau raug tso cai kho ntshav ntshav qab zib. Tshaj ua ke zoo siab nrog kev kho mob. Nrog cov piam thaj siab, cov tshuaj muaj peev xwm txo nws qib mus rau 6 mmol / L. Muaj qee qhov tshwm sim, tab sis lawv raug tshem tawm. Qhov kev yoo khoom noj yog xav tau.

Tus nqi ntawm gluconorm nyob rau ntau thaj tsam ntawm lub teb chaws muaj kev sib txawv. Tus nqi nruab nrab hauv lub tebchaws yog 212 rubles. Tus nqi ntau ntawm cov tshuaj yog 130-294 rubles.