Cov tshuaj Galvus: cov lus qhia rau kev siv, tshuaj xyuas, analogues

Nws tsis muaj qhov zais cia ntshav qab zib yog qhov kev tsim txom ntawm lub zej zog niaj hnub. Tus kab mob no cuam tshuam rau txiv neej thiab poj niam, hluas thiab laus, cov hluas thiab cov menyuam yaus. Feem ntau, cov kws kho mob tau sau ntawv rau Galvus ntsiav tshuaj, cov lus qhia rau kev siv uas yuav muab coj los tham hauv tsab xov xwm no.

Cov tshuaj no yog dab tsi? Qee lub sijhawm yog nws lub sijhawm teem tseg? Kuv yuav tsum noj nws li cas? Puas muaj kev tiv thaiv tsis haum rau nws siv? Txhua yam no tuaj yeem kawm tau los ntawm kev ua tib zoo kawm cov lus pom zoo ntawm cov kws tshaj lij thiab cov neeg mob, nrog rau lawv cov lus qhia ntawm "Galvus". Cov lus qhia rau kev siv, analogues tshuaj thiab lwm yam ntaub ntawv hais txog nws tuaj yeem pom hauv cov kab lus no.

Ua ntej tshaj plaws, qhov muaj pes tsawg leeg

Yog lawm, qhov no yog ib qho tseem ceeb tshaj plaws uas koj them sai sai thaum mus yuav tshuaj. Raws li cov lus qhia rau cov tshuaj "Galvus", nws cov tshuaj nquag muaj vildagliptin. Txhua lub ntsiav tshuaj muaj tsib caug milligrams ntawm cov khoom tiv thaiv no.

Lwm cov khoom xyaw suav nrog microcrystalline cellulose (yuav luag 96 milligrams), anhydrous lactose (li 48 milligrams), sodium carboxymethyl hmoov txhuv nplej siab (plaub milligrams), thiab magnesium stearate (2.5 milligrams).

Cov tsim khoom lag luam li cas

Raws li tau hais los saum toj no, twj twj tau nthuav tawm raws li ntsiav tshuaj. Cov tshuaj ntawm cov tshuaj yog ib txwm zoo li qub - tsib caug milligrams ntawm cov tshuaj nquag. Qhov no yog teev nyob rau hauv cov lus qhia rau kev siv nrog Galvus. Kev txheeb xyuas ntawm ntau tus neeg mob rwj mus rau qhov tseeb tias nws yooj yim heev. Tsis tas yuav saib cov ntawv ntim nrog rau cov tshuaj, rau kev ntshai ntawm kev kis tsawg dua lossis ntau dua li tsim nyog. Tsuas yuav cov khoom lag luam thiab coj nws raws li koj tus kws kho mob pom zoo.

Lub sijhawm twg thiaj tuaj yeem ua "Galvus 50"? Cov lus qhia rau kev siv cov tshuaj no muab cov lus teb hais txog nqe lus nug no.

Lub spectrum ntawm cov tshuaj

Raws li cov lus qhia, Galvus ntsiav tshuaj yog tshuaj rau cov neeg mob ntshav qab zib hom 2. Cov tshuaj no pab txhawb cov txiav ua leeg. Ua tsaug rau vildagliptin, cov ua tau zoo ntawm tag nrho cov kab mob hloov kho.

Raws li cov kws tshaj lij thiab cov neeg mob lawv tus kheej, "Galvus" yog tib txoj kev siv los kho hom mob ntshav qab zib thib ob, tshwj xeeb tshaj yog tias kev kho mob nrog cov khoom noj tshwj xeeb thiab qhia kev tawm dag zog.

Hauv qhov no, cov nyhuv ntawm cov tshuaj yuav ntev thiab kav ntev.

Muaj qee kis, qhov tshwm sim ntawm kev noj cov ntsiav tshuaj yuav tsis tshwm sim. Dab tsi yuav tsum tau ua hauv cov xwm txheej zoo li no? Thaum muaj xwm txheej zoo li no, raws li cov lus qhia rau kev siv thiab tshuaj xyuas cov neeg mob ntshav qab zib, "Galvus" yog tshuaj nrog rau lwm cov tshuaj raws li cov tshuaj insulin lossis lwm yam tshuaj uas txhawb tus txiav

Ua ntej pib kev sib tham ntxiv ntawm cov lus xaiv rau cov tshuaj, Peb maj mam saib tus kab mob, uas yog qhov tseem ceeb rau kev siv cov ntsiav tshuaj.

Yam 2 ntshav qab zib mellitus. Dab tsi yog qhov no

Qhov no yog hom mob ntshav qab zib mellitus ntau tshaj plaws, tus cwj pwm los ntawm kev tiv thaiv cov kab mob ntawm lub hlwb thiab lub cev nqaij mus rau cov insulin secreted los ntawm cov txiav. Qhov no txhais tau li cas hauv kev xyaum?

Cov tshuaj insulin yog tsim tawm hauv lub cev txaus los ntawm lub cev, tab sis cov kab mob ntawm lub cev rau qee lub laj thawj tsis cuam tshuam nrog nws. Kev rog, ntshav siab, ua rau muaj kev cuam tshuam, ua lub neej tsis muaj sia, muaj keeb thiab noj zaub mov tsis zoo (ua phem rau cov khoom qab zib, khoom qab zib, dej qab zib thiab cov khoom zoo sib xws tiv thaiv cov keeb kwm yav dhau los ntawm kev noj zaub tsawg, txiv hmab txiv ntoo thiab zaub yog suav tias yog qhov ua rau muaj kev cuam tshuam kev loj hlob ntawm tus kabmob).

Qhov kab mob endocrine no tshwm sim tau li cas? Nws yog qhov tseem ceeb heev uas yuav tsum paub txhawm rau txiav txim siab tus kabmob raws sijhawm thiab pib kho nrog "Galvus" lossis lwm yam tshuaj uas kws tshuaj los ntawm tus kws kho mob endocrinologist.

Ua ntej tshaj plaws, mob ntshav qab zib mellitus ntawm hom thib ob qhia tau nws tus kheej hauv kev nqhis dej tas li thiab lub qhov ncauj qhuav, ntau heev thiab nquag tso zis, tsis muaj zog ntawm cov leeg, tawv nqaij ua pob khaus, kho tsis zoo ntawm cov khawb thiab mob.

Kev kuaj mob ua rau mob hlwb nrog kev pab kuaj ntshav qab zib, kam rau ua qabzib, thiab lwm yam.

Hauv qee kis tshwj xeeb dab tsi tuaj yeem npaj qhov ncauj los ntawm cov kws tshwj xeeb?

Thaum twg yog cov tshuaj noj

Raws li cov lus qhia, cov tshuaj "Galvus" yog tshuaj los ntawm cov kws kho mob thaum kho mob hom 2 mob ntshav qab zib mellitus nyob rau theem ntawm txoj kev kho:

Thawj zaug. Ntawd yog, tsuas yog siv cov tshuaj hauv kev sib xyaw nrog cov khoom noj kom zoo thiab lub cev qoj ib ce.
Tshuaj Kho Mob. Txais tos ntawm vildagliptin thaum metformin yog contraindicated, txawm tias kev noj haus thiab kev tawm dag zog tsis muaj lub txiaj ntsig zoo rau tus neeg mob lub cev
Ob-tivthaiv (lossis kev sib txuas ua ke) kev kho. "Galvus" yog tshuaj nrog lwm cov kev tshwj xeeb (ntau dua ib qho, ib qho ntawm lawv): metformin, insulin, sulfonylurea derivatives thiab lwm yam.
Kev kho peb zaug. Thaum vildagliptin raug tso cai ua ke nrog kev noj cov tshuaj metformin thiab insulin lossis metformin thiab sulfonylureas.

Cov tshuaj ua li cas thaum nws nkag rau hauv tib neeg lub cev? Cia peb kawm saib.

Pharmacokinetic cov yam ntxwv ntawm cov tshuaj

Vildagliptin, tau txais sab hauv, yog nqus tau sai heev. Nrog kev ntsuas kev noj qab haus huv ntawm 85%, nws yuav nqus mus rau hauv cov ntshav ob teev tom qab noj. Qhov no yog pov thawj los ntawm kev qhia rau “Galvus”. Kev tshuaj xyuas ntawm cov kws tshawb fawb endocrinologist thiab lwm tus kws tshaj lij qhia tias muaj cov yam ntxwv ntawm cov tshuaj muaj txiaj ntsig ua rau nws muaj feem cuam tshuam sai rau tib neeg lub cev thiab nws kho tau nrawm.

Vildagliptin cuam tshuam nrog cov protein plasma thiab ntshav liab, tom qab ntawd nws ua rau lub raum ua haujlwm (li 85%) thiab cov hnyuv (15%).

Puas muaj kev sib kis ntawm cov tshuaj? Yog lawm, qhov no yuav tham ntxiv.

Thaum koj tsis tuaj yeem sau tshuaj

Raws li cov lus pom zoo ntawm cov kws kho mob thiab kev soj ntsuam cov neeg mob, Galvus yuav tsum tsis txhob noj yog tias ib tus neeg tau kuaj pom tus kab mob ntshav qab zib mellitus, yog tias muaj keeb kwm muaj mob ntshav plaub lub plawv tsis txaus, nrog rau cov kab mob xws li lactic acidosis, metabolic acidosis, lactose intolerance, myocardial infarction, pathological mob ntawm lub ua pa, kev ua xua, mob siab mob siab. Tsis tas li ntawd meej contraindications yog cev xeeb tub, lactation thiab lub hnub nyoog ntawm cov neeg mob mus txog kaum yim xyoo.

Ntxiv mus, thaum txiav txim siab seb puas yuav noj vildagliptin los yog tsis, tsis txhob hnov qab txog tus neeg tsis kam ua ntawm cov tshuaj ntawm cov ntsiav tshuaj, uas yog, kev fab tshuaj rau ob qho tib si tshuaj nquag nws tus kheej thiab cov koom haum pabcuam ntawm cov tshuaj.

Ua tib zoo saib, uas yog, nyob rau hauv kev saib xyuas thiab kev saib xyuas ntawm tus kws tshaj lij, txoj kev hais daws yog kho rau cov neeg mob kev tiv thaiv kab mob pancreatitis, mob plawv lossis ntau yam kab mob ntawm daim siab thiab lub raum.

Yuav ua li cas thiaj li yuav tsum tau noj cov tshuaj kom ntseeg tau tias nws qhov txiaj ntsig zoo?

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage form - ntsiav tshuaj: los ntawm lub teeb daj mus rau dawb, puag ncig, nrog cov ntug beveled, nrog rau qhov chaw du thiab NVR luam tawm ntawm ib sab, FB - nyob rau lwm qhov (7 pcs. Los yog 14 pcs. Hauv pob blister, hauv ib lub thawv ntawv) , 4, 8 lossis 12 lub hlwv thiab cov lus qhia rau kev siv Galvus).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: vildagliptin - 50 mg,
Lub cev ntu: sodium carboxymethyl hmoov txhuv nplej siab, anhydrous lactose, microcrystalline cellulose, magnesium stearate.

Cov lus qhia dav dav hais txog kev siv nyiaj

Cov ntsiav tshuaj tau noj tsis hais txog kev noj mov. Cov tshuaj yog ntxuav nrog ib qhov me me ntawm cov dej.

Kev noj tshuaj kho mob, koj yuav tsum tau saib xyuas cov ntshav qab zib kom tsis tu ncua uas siv cov tshuaj ntsuas glycemic.

Qhov tshuaj txhua hnub siab tshaj plaws yog ib puas milligrams ntawm vildagliptin.

Cov Tshuaj Hauv Tshuaj

Vildagliptin - cov tshuaj nquag ntawm Galvus, yog tus sawv cev ntawm chav kawm ntawm stimulants ntawm insular apparatus ntawm lub txiav. Cov tshuaj xaiv cov tshuaj inhibits qhov enzyme DPP-4 (dipeptidyl peptidase-4). Ua tiav (> 90%) thiab kev cuam tshuam sai sai ua rau muaj kev nce ntxiv ntawm qhov chaw pib thiab cov zaub mov-zais zais ntawm GLP-1 (hom 1 glucagon-zoo li peptide) thiab HIP (glucose-nyob rau insulinotropic polypeptide) rau hauv cov kab ke ntawm cov hnyuv thoob plaws hnub.

Nrog rau kev nce ntxiv ntawm qhov kev nkag siab ntawm GLP-1 thiab HIP, muaj qhov nce ntxiv ntawm qhov rhiab heev ntawm pancreatic cells-hlwb rau cov piam thaj, uas txhim kho cov piam thaj hauv cov kua dej insulin.

Hauv kev siv 50-100 mg vildagliptin ib hnub hauv cov neeg mob uas muaj ntshav qab zib hom 2 (ntshav qab zib mellitus), muaj kev txhim kho ntawm kev ua haujlwm ntawm pancreatic β-hlwb. Qhov ua tau zoo ntawm kev kho mob yog txiav txim siab los ntawm qib ntawm lawv qhov kev puas tsuaj thaum pib. Hauv cov tib neeg uas muaj ntshav qabzib feem ntau tsis muaj ntshav qab zib (tsis muaj ntshav qab zib), vildagliptin tsis txhawb cov tshuaj insulin zais thiab tsis txo cov ntshav qabzib. Nrog rau kev nce siab hauv cov kev ua kom tiav ntawm endogenous GLP-1, qhov kev cuam tshuam ntawm β-hlwb rau cov piam thaj nce, uas ua rau muaj kev txhim kho hauv cov kua nplaum ntawm cov kev cai ntawm glucagon tso pa tawm. Kev poob qis hauv kev nce siab ntxiv ntawm glucagon thaum noj mov, nyeg, ua rau kev poob qis hauv insulin tsis kam.

Nrog rau qhov nce ntawm qhov piv ntawm insulin / glucagon tiv thaiv keeb kwm ntawm hyperglycemia, uas yog vim muaj qhov nce ntawm cov concentration ntawm HIP thiab GLP-1, qhov txo qis hauv qabzib ntau los ntawm lub siab thaum / tom qab noj mov tau sau tseg. Yog li ntawd, muaj kev txo qis hauv cov ntshav plasma concentration ntawm cov piam thaj hauv cov ntshav.

Txais tos ntawm vildagliptin pab txo qhov kev kub siab ntawm lipids hauv cov ntshav ntshav tom qab noj mov, thaum cov nyhuv no tsis cuam tshuam nrog nws cov nyhuv ntawm GLP-1 lossis HIP thiab kev txhim kho ntawm kev ua haujlwm ntawm pancreatic islet hlwb.

Nws tau tsim tsa uas tau nce ntxiv ntawm qhov kev nkag siab ntawm GLP-1 tuaj yeem ua rau qeeb qeeb ntawm lub plab zom mov, txawm li cas los xij, thaum kho vildagliptin, cov txiaj ntsig zoo li tsis pom.

Raws li cov txiaj ntsig ntawm cov kev tshawb fawb, thaum siv vildagliptin raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog metformin, sulfonylurea derivatives, thiazolidinedione lossis insulin hauv cov neeg mob ntshav qab zib hom 2, qhov tseem ceeb tau txo qis nyob rau hauv cov concentration ntawm HbA1c (glycated hemoglobin) thiab kev ntshav sai yog teev.

Thaum coj los ua ke nrog kev kho mob nrog metformin raws li thawj txoj kev kho mob hauv cov neeg mob ntshav qab zib hom 2 rau 24 lub lis piam, qhov tshuaj tiv thaiv kab mob txo qis hauv qhov kev tso siab ntawm HbA1c tau pom muaj piv nrog kev kho mob monotherapy nrog cov tshuaj no. Hauv ob pawg kev kho mob, qhov tshwm sim ntawm cov ntshav qog ntshav muaj tsawg heev.

Thaum ua ntawv thov 50 mg ntawm vildagliptin 1 zaug ib hnub rau 6 lub hlis hauv cov neeg mob uas muaj ntshav qab zib hom 2 uas muaj qhov tsis zoo los sis lub raum tsis zoo (nrog lub siab txhaws ntawm tus nqi ≥ 30 thiab 2 lossis 2, feem ntau), qhov chaw kho mob txo qis hauv HbA1c concentration tau pom hauv qhov sib piv nrog tso cov tshuaj.

Qhov xwm txheej ntawm cov ntshav qab zib hauv cov pab pawg vildagliptin piv rau qhov ntawd hauv cov pab pawg placebo.

Cov Tshuaj Pharmacokinetics

Vildagliptin thaum noj ntawm qhov ncauj ntawm lub plab khoob sai sai, C_max (qhov siab tshaj plaws ntawm ib yam khoom) nyob rau hauv cov ntshav ntshav tau mus txog hauv 1.75 teev. Thaum muaj kev sib xyaw nrog kev noj zaub mov, tus nqi ntawm kev nqus ntawm vildagliptin tsawg dua: qhov txo qis hauv C_max los ntawm 19%, thaum lub sijhawm ua kom tiav nws nce li ntawm 2.5 teev. Txawm li cas los xij, kev noj zaub mov nyob rau qib ntawm kev nqus thiab AUC (thaj chaw hauv qab nkhaus "concentration - sijhawm") tsis muaj kev cuam tshuam.

Vildagliptin yog nqus tau sai, thiab nws qhov tseeb txog kev txheeb tsis taus yog 85%. C qhov tseem ceeb_max thiab AUC hauv kev kho mob ntau ntxiv nce ntxiv kwv yees qhov sib npaug ntawm cov koob tshuaj.

Cov tshuaj yog tus cwj pwm ntawm cov neeg tsis muaj kev khi ntawm cov ntshav plasma protein (ntawm qib 9.3%). Vildagliptin tau muab faib ncaj nruab nrab ntawm cov ntshav liab thiab ntshav ntshav. Kev faib tawm cov khoom tshwm sim, txawm tias, raug mob ntxiv, V_ss (qhov ntim ntawm kev faib tawm hauv qhov sib npaug) tom qab kev tswj hwm dej yog 71 litres.

Qhov tseem ceeb ntawm kev tshem tawm vildagliptin yog biotransformation, uas yog nthuav tawm rau 69% ntawm koob tshuaj. Lub ntsiab tshuaj tivthaiv yog LAY151 (57% ntawm koob tshuaj). Nws tsis ua rau pom kev ua lag luam pharmacological thiab yog cov khoom ntawm hydrolysis ntawm cyano tivthaiv. Txog li 4% ntawm cov koob tshuaj tiv thaiv amide hydrolysis.

Thaum lub sij hawm kawm preclinical, ib qho txiaj ntsig zoo ntawm DPP-4 ntawm hydrolysis ntawm vildagliptin tau tsim. Hauv cov metabolism hauv ib yam khoom, cytochrome P isoenzymes₄₅₀ tsis txhob koom nrog. Vildagliptin substrate isoenzyme P₄₅₀ (CYP) tsis yog, cytochrome P isoenzymes₄₅₀ tsis inhibit thiab tsis ntxias.

Tom qab noj cov vildagliptin sab hauv, kwv yees li 85% ntawm cov koob tshuaj yog tawm los ntawm lub raum, los ntawm txoj hnyuv - thaj tsam li 15%. Cov quav tsis ntxiv ntawm cov tshuaj tsis hloov pauv yog 23%. Nruab Nrab T_1/2 (ib nrab-lub neej) thaum muab cov khoom siv dej khov yog 2 teev, lub raum ntxuav thiab tag nrho cov ntshav ua kom huv ntawm vildagliptin yog 13 thiab 41 l / h, feem. T_1/2 tom qab lub qhov ncauj tswj hwm, tsis hais txog ntawm qhov koob tshuaj, yog li 3 teev.

Pharmacokinetic nta hauv cov neeg mob uas lub siab ua tsis tau zoo:

mob hnyav thiab mob hnyav (6–9 ntsiab lus ntawm Child-Pugh nplai): tom qab siv ib qho vildagliptin, nws txoj kev noj qab haus huv raug txo qis li 20% thiab 8%, feem.
mob hnyav (10-12 cov ntsiab lus ntawm Me-Pugh nplai): kev siv tsis tau ntawm vildagliptin nce ntxiv txog 22%.

Cov kev hloov pauv (nce lossis txo qis) hauv qhov siab tshaj plaws ntawm qhov khoom ntawd tshaj li 30% yog suav tias yog kev kho mob tseem ceeb. Tsis muaj kev cuam tshuam rau ntawm nruab nrab ntawm kev txiav txim plaub ntawm vildagliptin thiab qhov hnyav ntawm lub siab ua haujlwm tsis zoo.

Pharmacokinetic cov yam ntxwv hauv cov neeg mob uas lub raum tsis ua haujlwm tsis muaj qhov txawv, qib nruab nrab lossis mob hnyav (hauv kev sib piv nrog cov neeg pab dawb):

AUC ntawm vildagliptin: nce 1.4, 1.7 thiab 2 zaug, ua ntu zus,
AUC ntawm metabolite LAY151: nce los ntawm 1.6, 3.2 thiab 7.3 npaug, ntsig txog
AUC ntawm cov khoom siv metabolite BQS867: nce 1.4, 2.7 thiab 7.3 npaug, ntsig txog.

Cov ntaub ntawv tsis tshua muaj nyob hauv theem pib ntawm CKD (mob raum tsis zoo) qhia tias cov ntsuas hauv pawg no zoo ib yam li cov neeg mob uas muaj mob raum tsis zoo. Qhov kev sib zog ntawm LAY151 metabolite hauv lub davhlau ya nyob twg ntawm CKD nce li 2-3 zaug piv nrog qhov kev suav ntawm cov neeg mob uas muaj mob raum tsis zoo.

Nrog rau qhov mob hemodialysis, vildagliptin kev tshem tawm tsuas yog muaj tsawg (4 teev tom qab ib koob yog 3% nrog sijhawm ntev dua 3-4 teev).

Hauv cov neeg mob laus (tshaj 65-70 xyoo), qhov siab tshaj plaws ntawm kev noj qab haus huv ntawm vildagliptin los ntawm 32%, C_max - 18% tsis cuam tshuam rau DPP-4 kev cuam tshuam thiab tsis yog qhov tseem ceeb hauv tsev kho mob.

Cov tshuaj Pharmacokinetic tseem ceeb hauv cov neeg mob uas muaj hnub nyoog qis dua 18 xyoo tsis tau tsim.

Kev ntsuas rau siv

Kev siv ntawm Galvus yog qhia rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus thaum kev noj zaub mov noj tshuaj thiab kev tawm dag zog tau ua raws:

kev pib siv tshuaj kho mob hauv cov neeg mob uas tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab kev tawm dag zog - ua ke nrog metformin,
monotherapy, qhia rau cov neeg mob uas muaj kev sib txuam nrog kev noj cov tshuaj metformin lossis nrog nws qhov tsis muaj txiaj ntsig - nyob rau qhov tsis muaj kev saib xyuas los ntawm kev kho kev noj haus thiab kev tawm dag zog,
ob qho kev sib xyaw ua ke nrog kev kho mob nrog metformin, thiazolidinedione, sulfonylurea derivative lossis insulin - thaum tsis muaj kev kho mob los ntawm kev kho kev noj haus, kev tawm dag zog thiab monotherapy nrog ib qho ntawm cov tshuaj no,
triple ua ke txoj kev kho nyob rau hauv kev sib xyaw nrog metformin thiab sulfonylurea derivatives - thaum tsis muaj glycemic tswj tau zoo tom qab kev kho mob ua ntej nrog metformin thiab sulfonylurea derivatives nyob rau tom qab ntawm kev noj zaub mov noj thiab ce,
kev siv tshuaj peb zaug ua ke nrog kev sib xyaw nrog metformin thiab insulin - thaum tsis muaj glycemic txaus tswj tom qab kev kho mob ua ntej nrog insulin thiab metformin tiv thaiv keeb kwm ntawm kev noj zaub mov noj thiab ua exercise.

Cov Yuav Tsum Muaj

ntshav qab zib hom 1
hnub nyoog txog 18 xyoo
glucose-galactose malabsorption syndrome, galactose tsis haum, lactase tsis txaus,
mob ntsws raum ntshav IV tej chav kawm ua haujlwm raws li kev faib tawm muaj nuj nqi NYHA (New York Cardiology Association),
metabolic acidosis (mob ntshav qab zib ketoacidosis) nyob rau hauv daim ntawv muaj mob lossis mob hnyav (nrog rau suav nrog lossis tsis nco qab),
lactic acidosis (suav nrog keeb kwm),
lub siab ua haujlwm tsis zoo, suav nrog kev ua haujlwm ntawm daim siab enzymes alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST) 3 lossis ntau dua lub sijhawm siab dua li cov kev txwv siab dua ntawm ib txwm,
lub sijhawm cev xeeb tub thiab pub niam mis,
hypersensitivity rau lub Cheebtsam ntawm Galvus.

Nrog ceev faj, nws raug nquahu kom siv Galvus ntsiav tshuaj rau tus mob ua paug tsis muaj paug rau hauv anamnesis, theem davhlau ya nyob twg ntawm tus kab mob raum mob ntev (hauv cov neeg mob kho mob hemodialysis lossis mob hemodialysis), mob plawv tsis ua hauj lwm qib III raws li NYHA kev ua haujlwm faib tawm.

Galvus, cov lus qhia rau kev siv: txoj kev thiab ntau npaum li cas

Galvus ntsiav tshuaj noj ntawm qhov ncauj, tsis hais txog ntawm kev ua zaub mov.

Cov koob tshuaj yuav tsum raug xaiv coj mus rau hauv tus kheej qhov kev ua tau zoo thiab kev tiv taus ntawm cov tshuaj.

monotherapy lossis sib xyaw nrog thiazolidinedione, metformin lossis insulin: 50 mg 1-2 zaug ib hnub, tab sis tsis ntau tshaj 100 mg,
ob chav sib xyaw nrog kev kho mob sulfonylurea: 50 mg ib hnub ib zaug, thaum sawv ntxov. Hauv cov neeg mob ntawm pawg no, qhov kev kho mob ntawm kev noj Galvus hauv ib koob tshuaj 100 mg txhua hnub zoo ib yam li cov tshuaj ntawm 50 mg rau ib hnub,
kho peb zaug ua ke nrog kev tswj hwm tib txhij ntawm sulfonylurea thiab metformin derivatives: 100 mg rau ib hnub.

Yog tias qhov koob tshuaj txhua hnub yog 50 mg, nws tau noj ib zaug, thaum sawv ntxov, yog 100 mg - 50 mg thaum sawv ntxov thiab yav tsaus ntuj. Yog tias koj hla qhov kev siv tshuaj ntxiv tom qab ntawd, koj yuav tsum noj sai li sai tau thaum nruab hnub. Koj tsis tuaj yeem tso cai noj Galvus hauv ib koob tshuaj uas tshaj li tus neeg niaj hnub.

Thaum tsis muaj glycemic txaus tswj thaum lub sij hawm monotherapy ntawm qhov siab tshaj plaws txhua hnub 100 mg, kev kho yuav tsum tau ntxiv los ntawm kev teem sij hawm ntawm sulfonylurea, metformin, thiazolidinedione lossis insulin derivatives.

Nrog rau me me mus rau lub raum lub raum, qhov muaj peev xwm tsim cov tshuaj tsw qab (CC) siab tshaj 50 ml / min tsis hloov pauv ntawm Galvus.

Nrog mob pes tsawg (CC 30–50 ml / min) thiab mob hnyav (CC tsawg dua 30 ml / min) lub raum tsis ua haujlwm, suav nrog lub davhlau ya nyob twg ntawm tus mob raum (cov neeg mob los yog mob hemodialysis), koob tshuaj Galvus noj ib zaug, thiab nws tsis yuav tsum ntau tshaj 50 mg.

Hauv cov neeg mob laus (tshaj 65 xyoo), kev kho ntawm kev muab tshuaj ntau npaum li ntawm Galvus tsis yog yuav tsum tau ua.

Sab sij huam

Kev tsim kho ntawm qhov tsis xav tau thaum lub sij hawm monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg sawv cev hauv feem ntau yog mob me, ib ntus thiab tsis xav tau kev tshem tawm ntawm Galvus.

Cov tsos mob ntawm cov mob angioedema feem ntau pom thaum ua ke nrog angiotensin-hloov enzyme inhibitors. Feem ntau nws yog mob hnyav, hla ntawm nws tus kheej tawm tsam ntawm keeb kwm ntawm kev kho mob tsis tu ncua.

Tsis tshua muaj txiaj ntsig, kev siv Galvus ua rau mob siab thiab lwm yam kev cuam tshuam ntawm daim siab ua haujlwm ntawm chav kawm asymptomatic. Feem ntau, cov xwm txheej no tsis tas yuav muaj kev kho mob, thiab tom qab kev tshem tawm ntawm Galvus, lub siab ua haujlwm tau rov qab.

Kev nce ntxiv ntawm kev ua si ntawm hepatic enzymes ntawm koob tshuaj vildagliptin 50 mg 1-2 zaug hauv ib hnub hauv feem ntau yog asymptomatic, tsis nce zuj zus thiab tsis ua cholestasis lossis jaundice.

Nrog rau cov tshuaj monotherapy nyob rau hauv ib koob ntawm 50 mg 1-2 zaug hauv ib hnub, cov kev tsis zoo hauv qab no yuav tsim:

los ntawm cov leeg hlwb: feem ntau - kiv taub hau, tsis xws luag - mob taub hau,
cab thiab kis kab mob: muaj tsawg - nasopharyngitis, mob hlab pas sab sauv,
los ntawm cov hlab ntsha: ncaw - peripheral edema,
los ntawm kev mob plab hnyuv: ua haujlwm dhau los - cem quav.

Nrog kev sib xyaw ntawm Galvus hauv ib koob li 50 mg 1-2 zaug hauv ib hnub nrog metformin, qhov pom ntawm kev phiv yog muaj peev xwm ua tau:

los ntawm cov leeg hlwb: feem ntau - mob taub hau, tshee hnyo, kiv taub hau,
los ntawm kev mob plab hnyuv: feem ntau - xeev siab.

Kev sib xyaw ua ke nrog metformin tsis cuam tshuam rau tus neeg mob lub cev qhov hnyav.

Thaum ua ntawv thov Galvus hauv ib koob tshuaj 50 mg txhua hnub nrog sulfonylurea derivatives, cov kab mob hauv qab no tuaj yeem pom hauv tus neeg mob:

cab thiab kis kab mob: muaj tsawg - nasopharyngitis,
los ntawm lub plab zom mov: tshwm sim - cem quav,
los ntawm cov leeg hlwb: feem ntau - mob taub hau, tshee hnyo, kiv taub hau, asthenia.

Qhov hnyav ntawm tus neeg mob tsis nce ntxiv thaum ua ke nrog glimepiride.

Kev siv Galvus hauv ib koob ntawm 50 mg 1-2 zaug ib hnub hauv kev sib xyaw nrog thiazolidinedione derivatives tuaj yeem ua rau cov kev xav tsis zoo hauv qab no:

los ntawm cov hlab ntsha: feem ntau - peripheral edema,
los ntawm sab ntawm cov metabolism thiab khoom noj khoom haus: feem ntau - kev nce hauv lub cev hnyav.

Noj Galvus hauv ib koob li 50 mg 2 zaug hauv ib hnub nrog cov tshuaj insulin tuaj yeem ua rau:

los ntawm cov leeg hlwb: feem ntau - mob taub hau, nrog ib tus tsis paub tseeb - asthenia,
los ntawm lub plab zom mov: feem ntau - lub plab hnyuv plab zom mov, xeev siab, ua tsis xws luag - nrawm, raws plab,
los ntawm ib sab ntawm cov metabolism thiab khoom noj khoom haus: feem ntau - hypoglycemia,
cov teeb meem dav dav: feem ntau - ua daus no.

Qhov hnyav ntawm tus neeg mob hauv qhov kev sib txuam no tsis nce ntxiv.

Kev siv ntawm Galvus 50 mg 2 zaug hauv ib hnub nyob rau hauv ua ke nrog metformin thiab sulfonylurea npaj tuaj yeem ua rau kev txhim kho cov kev mob tshwm sim hauv qab no:

los ntawm ib sab ntawm cov metabolism thiab khoom noj khoom haus: feem ntau - hypoglycemia,
los ntawm cov leeg hlwb: feem ntau - tshee, kiv taub hau, asthenia,
dermatological tshua: feem ntau - hyperhidrosis.

Kev kho ua ke nrog peb zaug tsis cuam tshuam rau tus neeg mob lub cev qhov hnyav.

Tsis tas li ntawd, cov kev tshwm sim tsis zoo hauv qab no tau muab sau rau hauv cov kev tshawb fawb tom qab sau npe: urticaria, nce kev ua si ntawm daim siab enzymes, kab mob siab, kab mob ntsws, mob tawv nqaij ntawm tawv nqaij lossis exfoliative etiology, myalgia, arthralgia.

Noj ntau dhau

Thaum siv ntau txog 200 mg ntawm vildagliptin ib hnub, kev kho mob zoo txaus rau.

Thaum siv Galvus ntawm ib koob ntawm 400 mg ib hnub, cov tsos mob hauv qab no tuaj yeem raug sau tseg: mob leeg, tsis tshua muaj - ua npaws, mob ntsws / hloov ntawm lub caj dab, mob edema thiab ib qho kev hloov pauv ntawm lipase kev ua ub no (2 zaug siab dua li cov kev txwv sab sauv ntawm ib txwm).

Thaum lub sij hawm kho nyob rau hauv ib koob tshuaj txhua hnub ntawm 600 mg, cov tsos ntawm edema ntawm qhov kawg ntawm kev sib xyaw ua ke nrog paresthesia thiab qhov nce ntawm cov haujlwm ntawm CPK (creatine phosphokinase), myoglobin thiab C-reactive protein, thiab AST kev ua haujlwm yog ua tau.

Txhua yam kev hloov hauv chav kuaj thiab cov tsos mob overdose yog qhov thim rov qab thiab ploj tom qab tsis muaj kev kho mob.

Kev tshem tawm ntawm vildagliptin los ntawm lub cev siv cov tshuaj lim tsis txaus yuav tsis zoo. Los ntawm hemodialysis, metabolite LAY151 tuaj yeem tshem tawm hauv lub cev.

Cov lus qhia tshwj xeeb

Tus neeg mob yuav tsum tau qhia txog qhov yuav tsum tau mus ntsib tus kws kho mob thaum muaj kev nyuaj siab txog cov kev mob tshwm sim los yog cov tsos mob ntawm lwm qhov kev tsis txaus ntseeg nyob hauv keeb kwm yav dhau los ntawm kev siv ntsiav tshuaj.

Cov tshuaj tsis ua rau lub cev tsis muaj zog.

Hauv cov neeg mob tshuaj insulin, Galvus tsuas yog siv los ua ke nrog cov tshuaj insulin.

Hauv kev mob plawv tsis ua hauj lwm hauv chav kawm Kuv ua haujlwm kev faib tawm NYHA tshuaj muaj peev xwm ua yam tsis muaj kev txwv nyob rau hauv cov kev tawm dag zog lub cev.

Hauv kev mob plawv tsis ua hauj lwm hauv chav kawm II, yuav tsum tau txwv qee yam ntawm lub cev, vim tias lub nra ib txwm ua rau tus neeg mob plawv, tsis muaj zog, ua pa luv, nkees. Thaum so, cov tsos mob no tsis tuaj.

Yog tias cov tsos mob ntawm tus mob pancreatitis tshwm sim, vildagliptin yuav tsum tsis ua mus ntxiv.

Ua ntej pib siv thiab tom qab ntawd ua ntu zus txhua 3 lub hlis nyob rau thawj xyoo ntawm kev kho, nws raug nquahu kom ua kev tshawb nrhiav biochemical ntawm lub siab ua haujlwm kev ntsuas, vim tias kev ua haujlwm ntawm Galvus hauv qee qhov xwm txheej tsawg tuaj yeem ua rau muaj kev cuam tshuam ntawm aminotransferases. Yog tias thaum lub sijhawm kawm thib ob, cov kev ua haujlwm ntawm alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST) tshaj li kev txwv sab sauv ntawm qhov kev ntsuas los ntawm 3 zaug lossis ntau dua, cov tshuaj yuav tsum tau txiav tawm.

Nrog rau kev txhim kho cov cim ntawm lub siab ua haujlwm tsis zoo (suav nrog jaundice) thaum noj Galvus, kev txiav tawm tam sim ntawd ntawm cov tshuaj yog qhov yuav tsum tau, nws tsis tuaj yeem rov qab noj tom qab kho mob ntawm lub siab ua haujlwm ntsuas.

Txo cov kev pheej hmoo ntawm hypoglycemia thaum sib xyaw nrog sulfonylurea kev npaj, nws raug nquahu kom siv lawv hauv qhov tsawg kawg.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tib lub sijhawm Galvus nrog glibenclamide, metformin, pioglitazone, amlodipine, ramipril, digoxin, valsartan, simvastatin, warfarin, tsis muaj kev sib txuam tseem ceeb hauv tsev kho mob.

Cov nyhuv ntshav hypoglycemic ntawm vildagliptin tej zaum yuav raug txo qis thaum ua ke nrog thiazides, glucocorticosteroids, sympathomimetics, thiab cov thyroid hormones npaj.

Qhov ntxim nyiam ntawm kev txhim kho angioedema nce nrog concomitant kho nrog angiotensin hloov enzyme inhibitors. Nws yuav tsum raug sau tseg tias vildagliptin yuav tsum txuas mus ntxiv nrog cov tsos mob ntawm tus mob angioedema, vim nws dhau mus zuj zus, ntawm nws tus kheej thiab tsis tas yuav tsum tsis ua rau kev kho mob.

Kev sib cuam tshuam ntawm Galvus nrog cov tshuaj uas yog cov quav, ua kom pom tseeb lossis inhibitors ntawm cytochrome P yuav tsis zoo li₄₅₀ (CYP).

Galvus tsis muaj kev cuam tshuam rau cov tshuaj metabolic npaum li cas uas yog cov roj ntsha hloov pauv ntawm cov enzymes CYP1A2, CYP3A4, CYP3A5, CYP2C8, CYP2C9, CYP2D6, CYP2C19, CYP2E1.

Cov qauv ntawm Galvus yog: Vildagliptin, Galvus Met.

Yuav ua li cas coj thiab ntau npaum li cas

Ua ntej tshaj, nws yuav tsum tau hais tias lub sijhawm tswj hwm thiab kev noj ntau npaum li cas yog cov kws kho mob tau koom nrog, coj mus rau hauv tus kws kho mob ntawm chaw kho mob, tus mob tsis ua haujlwm thiab kev nyob zoo ntawm tus neeg mob. Txawm li cas los xij, cov lus qhia rau kev siv “Galvus” muaj cov lus qhia dav dav txog kev yuav siv cov tshuaj nyob rau qee qhov xwm txheej.

Thaum pib siv tshuaj lossis tshuaj tua kab mob, cov tshuaj "Galvus", raws li lub khw muag khoom lub ncauj lus, nws raug nquahu kom noj tsib caug milligrams ib hnub (lossis ib ntsiav tshuaj). Yog tias peb tab tom tham txog kev sib xyaw ntawm vildagliptin nrog metformin, tom qab ntawd cov tshuaj no tau noj ib ntsiav tshuaj ib hnub ob zaug.

Thaum siv vildagliptin nrog cov tshuaj muab los ntawm sulfonylureas, Galvus yog tshuaj rau tsib caug milligrams ib hnub ib zaug, thaum sawv ntxov.

Nrog rau kev kho peb zaug, cov tshuaj tau pom zoo kom noj ob lub tshuaj ob zaug ib hnub (thaum sawv ntxov thiab tsaus ntuj).

Yog hais tias tus neeg mob tsis txhob txwm noj tsis tau ntsiav tshuaj, tom qab ntawd nws yuav tsum ua kom sai li sai tau, me ntsis ncua sijhawm ntxiv tom qab siv tshuaj. Qhov no yog qhov tsim nyog nyob rau hauv kev txiav txim siab kom tsis txhob ntau tshaj qhov ua tau ntau npaum li cas txhua hnub ntawm vildagliptin hauv ib puas milligrams.

Yog tias tus neeg mob tau mob raum thiab mob hnyav raum, ces “Galvus” yuav tsum siv sab hauv ib hnub ib zaug, muab tshuaj rau ib hnub yog tsib caug milligrams.

Cov neeg mob uas muaj hnub nyoog qib siab, nrog rau cov neeg uas tau txais kev ua tsis zoo los kho lub raum, xws li kev kho cov tshuaj tsis tas yuav ua. Qhov no raug pov thawj los ntawm kev txheeb xyuas ntau ntawm cov neeg mob siab, uas muaj ntau tshaj li xya caum. "Galvus", zoo li tsis muaj lwm yam tshuaj, tau dhau los ua lawv cov tshuaj zoo rau ntshav qab zib.

Cov kev mob tshwm sim tuaj yeem tshwm sim thaum tab tom kho nrog vildagliptin? Yog lawm, thiab koj tuaj yeem nyeem txog nws hauv qab no.

Cov tsos mob tsis zoo

Feem ntau, qhov tsis xav tau qhov cuam tshuam yog lub sijhawm luv luv thiab tej zaum yuav muaj daim ntawv me. Hauv qhov no, nws tsis tas yuav thim qhov kev siv “Galvus”. Txawm li cas los xij, nws tseem tsim nyog qhia rau tus kws kho mob uas tau mus kawm txog kev qhia yam tsis zoo.

Kuv yuav tsum saib dab tsi thaum siv vildagliptin?

Ua ntej tshaj plaws, saib koj cov leeg poob siab. Koj puas muaj paroxysmal mob taub hau? Yog kiv taub hau, tshee hnyo hauv qhov kawg nkaus, thiab puas ntshai puas siab puas ntsws? Yog tias cov tsos mob hnyav zuj zus, yuav tsum kho qhov kev kho mob sai sai.

Puas yog "Galvus" nrog los ntawm daim tawv nqaij xoo pob thiab khaus? Ua daus no los yog kub taub hau? Thiab lub hnyuv hais dab tsi? Cem quav muaj ntau dua? Puas muaj xeev siab, ntuav, lossis zawv plab? Yog tias muaj, tom qab ntawd tus kws tsim tshuaj endocrinologist yuav daws qhov teeb meem no tiag.

Nws kuj tsim nyog kom them rau koj qhov hnyav. Puas muaj qhov nce ntxiv hauv lub cev nyhav tawm tsam keeb kwm ntawm kev noj haus thiab kev tawm dag zog lub zog? Feem ntau cov feem ntau, kev siv cov tshuaj ua ke nrog thiazolidinedione pab txhawb rau cov neeg tsis txaus ntseeg ua rau muaj kev hnyav ntxiv. Hauv qhov no, nws muaj qhov yuav tsum tau los saib xyuas qhov kev kho mob tau sau tseg.

Yuav ua li cas tsis yog overdose manifest

Nws tau raug pov thawj hais tias vildagliptin feem ntau pom tau los ntawm lub cev txawm tias thaum noj ob puas milligrams nyob rau ib hnub. Txawm li cas los xij, kev haus luam yeeb ntau dhau ntawm cov tshuaj tseem ceeb tuaj yeem ua rau kev twv tsis tau thiab qhov tshwm sim. Ua ntej tshaj plaws, qhov no yog hais txog qhov nce ntxiv ntawm qhov koob thib ob tau hais los saud. Hauv qhov no, cov leeg mob hnyav, ua npaws, thiab o tuaj yeem tshwm sim. Yog tias qhov koob tshuaj txhua hnub tau nce mus rau rau pua plhom milligrams, tom qab ntawd qhov xwm txheej zoo sib xws yuav ua rau muaj kev txhawm rau mob hnyav thiab mob ntawm qhov ncauj sab saud thiab qis dua thiab lwm yam kev cuam tshuam tsis zoo hauv cov dej num ntawm tag nrho cov kab mob.

Kev kho mob hauv qhov xwm txheej no tuaj yeem yog mob hemodialysis hauv tsev kho mob.

Vildagliptin thiab lwm tus neeg sawv cev pharmacological

Raws li tau hais los saum toj no, kev siv "Galvus" nrog cov tshuaj raws li metformin, insulin, sulfonylurea thiab lwm tus tau xyaum. Ntxiv mus, cov tshuaj yeeb tshuaj tuaj yeem ua ke ywj pheej nrog kev siv digoxin, ramipril, valsartan, simvastatin thiab lwm yam.

Cov nyhuv ntawm vildagliptin yog txo los ntawm cov neeg sawv cev uas nws cov tshuaj muaj yees yog cov thyroid hormones, sympathomimetics, glucocorticosteroids thiab lwm yam.

Npaj tos hloov Galvus

Raws li tau hais saud, cov tshuaj yuav tsis haum rau tus neeg mob. Dab tsi yuav tsum tau ua nyob rau hauv cov ntaub ntawv no? Tus kws kho mob mus koom puas yuav sau tshuaj rau noj? Yog li, txhais tau li cas peb tuaj yeem xav txog cov khoom sib piv ntawm "Galvus"? Cov lus qhia rau kev siv cov tshuaj yuav sib tham hauv qab no.

Yog tias peb tham txog lub spectrum ntawm kev nqis tes ua, tom qab ntawd qhov hloov pauv zoo rau vildagliptin yog txoj kev daws teeb meem rau kev txhaj tshuaj "Baeta". Cov tshuaj nquag siv ntawm cov tshuaj yog exenatide (250 micrograms hauv ib milliliter). Kev qhia rau siv yog mob ntshav qab zib mellitus ntawm hom ob."Baeta" yog tau sau ua qauv ntawm kev txhaj tshuaj subcutaneous hauv tus ncej, ceg, hauv plab. Tsib micrograms ntawm cov khoom xyaw nquag yog siv ob zaug ib hnub rau caum feeb ua ntej noj mov thaum sawv ntxov thiab yav tsaus ntuj. Nws yog siv raws li kev kho mob monotherapy thiab kev sib koom ua ke (sib xyaw) nrog metformin, thiazolidinedione thiab lwm tus. Tus nqi ntawm cov tshuaj nyob rau hauv rau caum koob tshuaj yuav ua tau ntau dua tsib txhiab rubles.

"Januvia" yog lwm qhov zoo sib xws ntawm "Galvus", uas ua rau hauv cov qauv ntawm cov ntsiav tshuaj, qhov tseem ceeb ntawm cov uas yog sitagliptin phosphate hydrate. Cov tshuaj yog siv los kho hom 2 mob ntshav qab zib mellitus nrog kev kho tshuaj thiab kho txoj kev kho mob kom zoo. Cov koob tshuaj pom zoo ntawm cov tshuaj yog ib puas milligrams ntawm lub ntsiab feem ib zaug ib hnub. Cov tshuaj ntsiav muaj nyob hauv ntau yam tshuaj ntawm cov tshuaj nquag. Tus nqi nruab nrab ntim ntawm 28 ntsiav tshuaj yog 1,500 rubles.

"Onglisa" yog lwm cov tshuaj noj uas yog ib qho tshuaj ntawm cov tshuaj uas peb xav tau. Cov sib xyaw ua ke ntawm "Onglisa" suav nrog saxagliptin, uas yog cov tshuaj ua kom nquag plias. Feem ntau, cov tshuaj tau muab qhov ncauj ntawm tsib milligrams (ib ntsiav tshuaj) ib hnub ib zaug. Koj tuaj yeem noj cov tshuaj tsis hais txog pluas noj li cas. Tus nqi ntawm kev ntim cov ntsiav tshuaj hauv peb caug daim mus txog 1,900 rubles lossis ntau dua.

Txawm li cas los xij, feem ntau cov kws endocrinologist hloov Galvus nrog nws cov tshuaj tiv thaiv ncaj qha - Galvus Met ntsiav tshuaj, cov khoom tseem ceeb ntawm cov uas yog vildagliptin (hauv tsib caug milligrams) thiab metformin (hauv qhov nyiaj 500, 850 lossis 1,000 milligrams). Ua tsaug rau qhov kev sib txuam no, cov tshuaj tswj cov metabolism thiab txo qis cov cholesterol. Muab tso rau los ntawm tus kws kho mob endocrinologist, pib nrog kev noj tsawg kawg nkaus (tsib caug milligrams ntawm vildagliptin thiab tsib puas milligrams ntawm metformin). Nws ntseeg tau tias cov tshuaj no muaj cov kev mob me me rau lub cev ntawm tus neeg mob mob ntshav qab zib ntau dua li cov tshuaj ntawm kev txaus siab rau peb. Tus nqi ntawm Galvus Met ntsiav tshuaj yog kwv yees li 1,500 rubles.

Raws li koj tuaj yeem pom, muaj ntau ntau yam ntawm "Galvus" analogues uas txawv ntawm txhua lwm yam hauv kev sib xyaw, daim ntawv ntawm qhov teeb meem thiab cov cai tswj hwm nqe. Qhov twg yog qhov zoo rau koj - tus kws kho mob txiav txim siab, coj mus rau hauv tus account daim duab dav dav ntawm tus kabmob, nrog rau tus kheej ntawm tus yam ntxwv ntawm tus neeg mob.

Ob peb lo lus thaum kawg

Raws li koj tuaj yeem pom, cov tshuaj "Galvus" yog ib qho ntawm cov pheej yig txhais tau tias yuav pab tau cov neeg mob kev mob ntshav qab zib hom 2. Cov ntsiav tshuaj, tso tawm rau ntawm lub hauv paus ntawm vildagliptin, txhawb cov txiav ua leeg, muaj kev cuam tshuam zoo rau tag nrho lub cev ntawm tus neeg mob. Cov tshuaj tuaj yeem siv ua kev kho tus kheej, nrog rau kev sib xyaw nrog lwm cov tshuaj.

Txawm hais tias qhov txiaj ntsig zoo, "Galvus" muaj cov npe loj ntawm cov lus sib txuas thiab cov kev mob tshwm sim, yog li koj tsis tuaj yeem muab koj tus kheej tso. Cov sij hawm tswj hwm thiab kev noj tshuaj yog tsim los ntawm tus kws kho mob uas koom nrog.

Coob tus neeg mob zoo siab tias lawv tau siv cov tshuaj no, vim tias nws yog cov txiaj ntsig zoo los txo cov ntshav qab zib thiab txhim kho tus neeg mob kom zoo. Thiab tib lub sijhawm, lawv paub tias vildagliptin yog qhov zoo tshaj plaws siv nrog metformin txhawm rau txhim kho kev ua tau zoo thiab muaj txiaj ntsig ntawm cov tshuaj nquag.