Yuav siv Fenofibrate li cas?

Fenofibrate yog ib qho lipid txo qis siv tshuaj uas siv los kho hypercholesterolemia thiab sib xyaw hyperlipidemia. Qhov zoo yog nyob ntawm kev ua haujlwm ntawm PPARα cov txais. Cov tshuaj feem ntau yog noj ib zaug ib hnub nrog zaub mov. Feem ntau cov kev mob tshwm sim feem ntau yog mob taub hau thiab kem plab. Fenofibrate tuaj yeem ua rau tawv nqaij tiv thaiv tshav ntuj.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Fenofibrate muaj nyob rau hauv daim ntawv ntawm cov dawb crystalline hmoov, uas yog xyaum insoluble hauv dej. Ib qho prodrug yog metabolized nyob rau hauv lub cev mus rau nquag fenofibric acid.

Tam sim no (2018), micronized fenofibrate siv feem ntau.

Nthuav! Cov tshuaj yeeb tshuaj tau tsim los ntawm lub tuam txhab kev lag luam Fournier Pharma. Hauv Tebchaws Asmeskas, nws tau dhau los ua cov yeeb yaj kiab kho mob lipid-txo qis tshaj plaws ntawm kev ua lag luam.

Cov chaw muag tshuaj

PPARs yog cov tshuaj tiv thaiv nuclear uas tau ua haujlwm los ntawm ntuj lossis hluavtaws ligands, thiab kuj nce lossis txwv rau kev qhia ntawm qee yam caj ces. Muaj cov PPA alpha, beta thiab gamma receptors. Yuav luag txhua qhov fibrates tshwj xeeb khi rau alpha receptors.

Cov teebmeem tseem ceeb ntawm cov tshuaj:

• Nws inhibits qhov qhia ntawm apolipoprotein C3 (APOC3), uas nyeg inhibits lipoprotein lipase lub luag hauj lwm rau lub hydrolysis ntawm intravascular triglycerides (TG). PPAR-alpha nce cov haujlwm ntawm lipoprotein lipase, uas ua rau txo qis ntawm triglycerides hauv cov ntshav
• Txhim kho qhov sib xyaw ntawm APOA1, APOA2 thiab yog li ntawd HDL
• Thaum lub sijhawm cov kev sim kho mob ua nrog fenofibrate, tag nrho cov ntshav cov roj nyob rau hauv 20 thiab 25%, thiab HDL nce ntxiv ntawm 10 mus rau 30%
• Txo txo ​​cov kev qhia ntawm endothelin-1, uas yog vasoconstrictor haib. Tsis tas li ntawd, nrog cov txheej txheem no, fibrates txo cov kev qhia ntawm cytokines, tshwj xeeb tshaj yog IL-1 thiab IL-6, yog li, lawv muaj qhov ua tau zoo los tiv thaiv. Nws tseem paub zoo tias siv PPAR-alpha, qee cov fibrates tuaj yeem txo qhov kev qhia ntawm fibrinogen, yog li lawv muaj peev xwm muaj cov nyhuv antithrombotic
• Nce cov zais ntawm cov roj (cholesterol) los ntawm cov kua tsib, uas tuaj yeem pab txhawb rau lithogenesis.

Qhov siab tshaj plaws ntshav plasma concentration (Cmax) tau tiav 2-4 teev tom qab kev tswj hwm ntawm qhov ncauj. Bioavailability muaj peev xwm txo qis yog tias siv yeeb tshuaj nrog cov zaub mov. Tom qab kev tswj hwm ntawm qhov ncauj, fenofibrate tau nrawm nrawm los ntawm esterases mus rau hauv lub cev nquag metabolite - fenofibric acid. Fenofibric acid yog txuam nrog ntshav albumin (ntau dua li 98%). Tsis muaj qhov txawv txav fenofibrate tau pom nyob hauv ntshav. Cov tshuaj tsis muaj txheej txheem rau cytochrome P450. Cov tshuaj tsis koom nrog hepatic microsomal metabolism.

Cov tshuaj yog tshem tawm los ntawm lub cev tsuas yog nrog zis. Yuav luag txhua qhov khoom lag luam tshem tawm hauv ib lim tiam. Fenofibrate feem ntau tshem tawm hauv daim ntawv ntawm fenofibric acid thiab nws glucuroconjugate derivative. Hauv cov neeg mob laus, qhov kev tshem tawm ntawm fenofibric acid tsis hloov. Pharmacokinetic cov kev tshawb fawb tom qab siv ib koob thiab kev kho mob tas li qhia tau tias tsis muaj kev txuam nrog. Fenofibric acid tsis yog tshem tawm los ntawm cov txheej txheem lim ntshav. Ib nrab-lub neej nyob nrog txog 20 teev.

Kev ntsuas rau siv

Tus nqi nruab nrab ntawm Fenofibrate yog 800 Lavxias rubles.

Fenofibrate yog siv ntxiv rau kev noj haus lossis lwm yam tsis siv tshuaj (xws li qoj ib ce, poob phaus) hauv kev kho mob ntawm hom II, III, IV thiab V hyperlipidemia. Fenofibrate yuav tsum raug suav tias yog kev siv tshuaj thib ob. Cov tshuaj tuaj yeem siv tsuas yog thaum pom ntau dhau ntawm cov lipids hauv cov ntshav pom. Nws kuj tseem yuav tsum tau siv los ua lwm txoj hauv kev yog tias lwm cov tshuaj nquag los ntawm pawg statin tsis ua haujlwm lossis tsis raug sib kis.

Hauv kev tshawb fawb, kev kho fenofibrate txo qis zaus ntawm kev mob plawv hauv cov kab mob plawv. Txawm li cas los xij, nws tsis tau tsim muaj tias cov tshuaj muaj cov txiaj ntsig zoo ntawm kev txhim kho cov kab mob plawv.

Cov lus qhia rau kev siv

Raws li cov lus qhia, fenofibrate feem ntau tau noj ib hnub ib zaug. Tib lub sij hawm ua kom cov zaub mov me ntsis txo qis dua qhov kev nyab xeeb ntawm cov tshuaj. Nws raug nquahu kom haus cov ntsiav tshuaj nrog dej.

Siv thaum cev xeeb tub thiab pub mis niam tsis pom zoo, vim tias, raws li cov lus qhia rau kev siv, cov tshuaj muaj cov nyhuv teratogenic.

Cov kev txuam nrog, phiv ntau dhau, noj ntau dhau, sib txuam tshuaj

Fenofibrate yog contraindicated nyob rau hauv rooj plaub ntawm hypersensitivity, nephropathy, daim siab tsis ua hauj lwm, mob siab rau hepatic kawg, kab mob ntawm lub zais zis, yav dhau los photoallergic lossis phototoxic cov tshuaj tiv thaiv. Yog tias tawv nqaij tawv nqaij tawv nqaij (ua rau lub ntsej muag cov tshuaj tiv thaiv) nrog daim tawv liab, tawm pob, los ntshav thiab khaus, cov khoom xyaw ua si yuav tsum tau tsum tsis ua ntxiv.

Nws raug pom zoo tias koj yuav tsum qhia koj tus kws kho mob tam sim ntawd ntawm qhov mob, tsis muaj zog, thiab mob nqaij. Cov poj niam ntawm kev xeeb menyuam muaj peev xwm yuav tsum them sai sai rau kev tiv thaiv kom zoo thaum lub sijhawm kho.

Fenofibrate ua rau lub plab zom mov thiab lub plab ua kom zoo, nce daim siab enzymes, qhov concentration ntawm homocysteine. Nws kuj tseem ua rau mob nqaij mob, ua pob ua xua, mob ua paug ntawm lub pob zeb, thiab nce qib creatine kinase qib. Cov kev tshawb fawb soj ntsuam tau qhia meej tias cov tshuaj muaj peev xwm ua rau muaj kev nyuaj siab tsis zoo nrog rau kev siv sijhawm ntev.

Kev sib cuam tshuam yeeb tshuaj muaj peev xwm ua tau nrog tshuaj tiv thaiv qhov ncauj, cyclosporine, tshuaj hepatotoxic thiab monoamine oxidase blockers. Fenofibrate yog qhov tshuaj tiv thaiv qee yam cytochrome P450 isoforms.

Cov analogues tseem ceeb ntawm Fenofibrate: Fenofibrate Canon thiab Tricor.

Fenofibrat Canon

Chaw Tsim Tshuaj - Canonfarm Ntau Lawm CJSC (Lavxias Federation)

Nqi - los ntawm 820 rubles

Cov lus piav qhia - cov yeeb yaj kiab-nyias cov ntsiav tshuaj uas siv los kho ntshav cov ntshav

Pov thawj - txo qhov concentration ntawm lipoproteins tsawg thiab tsis tshua muaj siab, nce HDL thiab muaj cov nyhuv antithrombotic hauv kev kho mob

Cons - ua rau qaug zog, mob taub hau, ntxhov siab, mob plab, mob siab thiab mob raum tsis ua haujlwm

Chaw tsim tshuaj paus - Recipharm Fontaine (Fabkis)

Nqi - los ntawm 1200 rubles

Cov lus piav qhia - cov yeeb yaj kiab-cov ntsiav tshuaj uas muaj micronized fenofibrate, uas yog siv los kho cov khoom muaj roj ntau ntau thiab triglycerides hauv cov ntshav

Pov thawj - txo qhov concentration ntawm LDL, VLDL, fibrinogen thiab nce HDL. Cov ntsiab lus ntawm cov cim ntawm qhov mob thiab uric acid hauv cov hlab ntshav kuj tseem poob qis.

Cons - ua rau mob dyspepsia, nce nplooj siab enzymes, daj ntseg, mob qog, rhabdomyolysis, mob erectile kawg thiab mob cephalgia.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm nyias daim nyias nyias ntsiav tshuaj. Ib qho seem ntawm cov tshuaj muaj 145, 160 lossis 180 mg ntawm micronized fenofibrate nyob rau hauv daim ntawv ntawm nanoparticles. Raws li cov khoom siv ntxiv tau siv:

• mis nyuj qab zib
• microcrystalline cellulose,
• crospovidone
• hypromellose,
• dehydrogenated silicon dioxide colloidal,
• sucrose
• lauryl sulfate thiab docusate sodium,
• magnesium stearate.

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm nyias daim nyias nyias ntsiav tshuaj.

Lub plhaub sab nraud muaj talc, xanthan ntawm cov pos hniav, titanium dioxide, polyvinyl cawv thiab socithin kua. Cov ntsiav tshuaj dawb muaj lub ntsej muag zoo nkauj nrog lub ntsej muag ntawm ob sab ntawm daim ntawv tshuaj, qhia thawj thawj tsab ntawv ntawm cov tshuaj nquag thiab muab tshuaj.

Mechanism ntawm kev ua

Fenofibrate ntsiav tshuaj belongs rau cov pab pawg neeg ntawm hypoglycemic tus neeg sawv cev thiab yog ib qho kev sib txuas ntawm fibroic acid. Qhov tshuaj yeeb dej caw no muaj peev xwm cuam tshuam rau theem ntawm lipids hauv lub cev.

Cov yam ntxwv ntawm kws tshuaj yog vim kev ua haujlwm ntawm RAPP-alpha (ib qho tshuaj lom los ntawm peroxisis proliferator). Raws li qhov tshwm sim dhau los ua kom lub zog hloov zuj zus, cov txheej txheem kev zom zaub mov muaj roj tsawg thiab qhov kev nthuav tawm ntawm cov ntshav qis lipoproteins (LDL) tau zoo tuaj. Kev tsim cov tshuaj apoproteins AI thiab AH yog kho kom zoo dua, vim tias qib uas muaj cov lipoproteins ntau (HDL) tau nce li ntawm 10-30% thiab lipoprotein lipase yog ua haujlwm.

Vim tias txum tim rov qab los ntawm cov roj metabolism hauv kev ua txhaum cai ntawm kev tsim ntawm VLDL, fenofibrate compound nce lub zog ntawm LDL, txo tus naj npawb ntawm cov ntom ntom ntawm cov lipoproteins uas tsis muaj qhov loj me.

Cov qib LDL nce rau hauv cov neeg mob uas muaj kev pheej hmoo txhim kho mob rau cov ntshav hlab plawv.

Cov tshuaj yuav pab txo cov roj hauv 20-25% thiab triglycerides txog 40-55%. Nyob rau hauv muaj hypercholesterolemia, qib ntawm LDL-txuam nrog cov cholesterol txo qis mus rau 35%, thaum hyperuricemia thiab atherosclerosis txo qis hauv kev saib xyuas ntawm uric acid hauv cov ntshav los ntawm 25%.

Cov Tshuaj Pharmacokinetics

Thaum noj ntawm qhov ncauj, micronized compound ntawm fenofibrate yog nqus rau qhov ze ntawm txoj hnyuv me siv microvilli, los ntawm qhov chaw uas nws tau nqus rau hauv cov hlab ntshav. Thaum nws nkag mus rau hauv txoj hnyuv, cov tshuaj nquag tam sim ntawd decomposes rau fenofibroic acid los ntawm hydrolysis nrog esterases. Cov khoom lwj ua kom tiav mus txog cov ntshav siab tshaj plaws nyob rau hauv 2-4 teev. Noj ntawm tus nqi ntawm kev nqus thiab bioavailability tsis cuam tshuam vim yog nanoparticles.

Thaum nws nkag mus rau hauv txoj hnyuv, cov tshuaj nquag tam sim ntawd decomposes rau fenofibroic acid los ntawm hydrolysis nrog esterases.

Hauv cov roj ntsha, cov nquag sib xyaw ua ke khi rau ntshav albumin los ntawm 99%. Cov tshuaj tsis koom nrog microsomal metabolism. Ib nrab-lub neej nyob ntev txog 20 teev. Hauv kev sim tshuaj kho mob, tsis muaj ib qho kev ua txhaum cai ntau nrog ob qho tib si lossis nrog lub sijhawm ntev tswj hwm ntawm cov tshuaj. Hemodialysis tsis muaj txiaj ntsig. Cov tshuaj tau tawm hauv cov qauv fenofibroic acid tag nrho ua ntej 6 hnub los ntawm kev tso zis.

Cov Yuav Tsum Muaj

Cov tshuaj tsis tau sau tseg vim yog ua tiav contraindications:

• hypersensitivity rau fenofibrate thiab lwm yam kev teeb tsa ntawm cov tshuaj,
• daim siab mob
• mob raum khiav tsis zoo,
• cov kab mob ua rau cov leeg galactosemia thiab fructosemia, cov tsis muaj lactase thiab sucrose, cov ntshav qab zib tsis txaus thiab galactose haum,
• keeb kwm muaj keeb kab mob leeg mob,
• rhiab rau lub teeb thaum kho nrog Ketoprofen lossis lwm yam ntawm cov fibrates,
• pathological txheej txheem nyob rau hauv lub gallbladder.

Cov tshuaj tsis tau sau tseg rau cov muaj keeb galactosemia.
Cov tshuaj tsis raug txwv rau cov kab mob siab.
Cov tshuaj tsis tau teev tseg rau cov mob muaj keeb fructosemia.
Cov tshuaj tsis yog kws kho rau kev ua haujlwm tsis zoo hauv lub raum.
Cov tshuaj tsis tau sau tseg rau cov mob muaj keeb ua cov leeg mob hauv keeb kwm.
Cov tshuaj tsis tau sau tseg rau cov txheej txheem pathological hauv lub zais zis.

Cov neeg uas muaj kev phiv tshuaj anaphylactoid rau cov txiv laum huab xeeb thiab txiv laum huab xeeb yuav tsum tsis txhob noj cov tshuaj.

Cov pab pawg tshuaj, INN, thaj tsam

Fenofibrate belongs rau cov pab pawg tshwj xeeb - lipid-txo cov tshuaj ua rau lub hauv paus ntawm fibroic acid. Cov tshuaj no muaj peev xwm txo cov kev sib txuam ntawm cov "phem" cov roj cholesterol hauv cov ntshav thiab txo qis ntawm triglycerides.

Cov tshuaj siv los txo cov kev kub siab ntawm lipids, kev nthuav dav ntau dhau ntawm uas cuam tshuam tsis zoo rau tib neeg kev noj qab haus huv. Feem ntau nws tau sau tseg rau cov neeg mob ntshav qab zib mellitus, nrog pathologies ntawm lub plawv thiab cov hlab ntsha (piv txwv, mob ischemia, atherosclerosis) txhawm rau kho cov qib ntawm lipids.

INN yog Fenofibrate, vim nws yog qhov khoom sib xyaw no uas muaj nyob hauv cov tshuaj thiab txiav txim siab lub tshuab ntawm nws cov kev coj ua ntawm lub cev.

Tso daim ntawv, nqi hauv Lavxias

Cov tshuaj tau tawm hauv cov ntsiav tshuaj uas muaj xim dawb, lub npov sib npaug thiab sib faib ua ke. Txhua lub tshuaj muaj 145 mg ntawm cov tshuaj ua kom nquag plias. Lawv muab ntim ua cov hlwv yas rau 7, 10 lossis 15 daim. Nyob rau hauv tag nrho, hauv cardboard lub thawv muaj los ntawm 10 txog 100 ntsiav tshuaj.

Tus nqi nyob ntawm tus naj npawb ntawm cov ntsiav tshuaj hauv pob, ntxiv rau ntawm qhov chaw ntawm kev yuav tshuaj. Tus nqi nruab nrab rau ib pob ntawm 30 ntsiav tshuaj ntawm 145 mg nyob rau hauv cov khw muag tshuaj ntawm cov nroog loj hauv tebchaws Russia tau nthuav tawm hauv lub rooj.

Tus nqi pheej yig tshaj plaws yog muab los ntawm cov khw muag tshuaj online. Muaj koj tuaj yeem xaj kom xa ncaj qha rau koj lub tsev.

Cov sib txuas ua ke

Lub ntsiab kom nquag plias cov tshuaj tiv thaiv yog fenofibrate. Nws raug xa mus ua fibroic acid derivatives (fibrates). Ib ntsiav tshuaj muaj 145 mg ntawm cov tshuaj no. Tsis tas li ntawd, cov tshuaj muaj pes tsawg leeg suav nrog cov khoom sib xyaw - cellulose, magnesium stearate, povidone, mannitol, hmoov txhuv nplej siab, silicon dioxide. Lawv muaj cov koom tes pabcuam.

Cov Khoom Siv Tshuaj Kho Mob

Fenofibrate muaj peev xwm ua kom muaj alpha receptors tshwj xeeb (RAPP). Qhov no ua rau kom lipolysis nce ntxiv thiab tshem tawm cov phom sij lipoproteins txaus los ntawm cov ntshav, uas tuaj yeem muaj ntau zuj zus thiab muab tso rau ntawm cov phab ntsa ntawm cov hlab ntshav, ua rau muaj qhov tsis zoo. Hauv qhov no, cov teebmeem hauv qab no raug pom:

• txo hauv triglycerides thiab roj (cholesterol) phem,
• txo qis npaum li cas ntawm cov uric acid (uricosuric effect),

normalization ntawm platelet aggregation (kev tiv thaiv ntawm thrombosis),

Tom qab kev tswj hwm ntawm qhov ncauj, cov tshuaj yuav cuam tshuam tag nrho lub plab zom mov tom qab 4 teev. Yog tias nws yog cov kab ke hauv txoj kev noj, yog li cov siab nyob hauv cov ntshav ntawm cov tshuaj nquag yuav hloov tas mus li. Fenofibrate khi yuav luag tag nrho cov ntshav protein.

Nyob rau hauv tus txheej txheem ntawm nws ua fenofibroic acid yog tsim. Tsis koom nrog hauv cov metabolism hauv microsomal. Kev tshem tawm yog tshwm sim los ntawm lub raum. Ib nrab-lub neej yog pom 20 teev tom qab kev coj. Nws yuav siv li 6 hnub kom tiav cov khoom ntawm fenoforbit metabolites.

Kev taw qhia thiab kev txwv

Cov tshuaj yog tshuaj kom txo tau cov qib ntawm triglycerides thiab cov roj uas txhaws taus tsawg nrog cov pathologies:

Mixed dyslipidemia. Nws feem ntau loj hlob nrog cov kab mob zoo li no:

• mob ntshav qab zib mellitus
• ischemia
• atherosclerotic cov txheej txheem hauv cov hlab ntsha peripheral lossis carotid,
• lub plab aneurysm mob plab,
• lwm cov kev mob caj dab. Cov tshuaj no feem ntau siv ua ke nrog cov statins kom txo qis triglycerides thiab nce HDL (cov roj cholesterol zoo).

Sij hawm thiab txheej txheem kho yog txiav txim los ntawm tus kws kho mob uas tuaj koom. Ua ntej sau ntawv yuav tshuaj, koj yuav tsum paub tseeb tias tus neeg mob tsis muaj kev tiv thaiv zoo li no:

• tus kheej tsis kam rau lub Cheebtsam ua cov yeeb tshuaj,
• mob raum tsis ua haujlwm
• hypersensitivity rau fibrates thiab Ketoprofen,
• rhuav tshem rab qau,
• Mob leeg nqaij lossis mob txha cajqees (dua li qhov uas tshwm sim los ntawm hypertriglyceridemia),
• cov menyuam yaus thiab cov hluas,
• lub sij hawm GW,
• cev xeeb tub
• lub siab ua haujlwm tsis ua haujlwm (mob ntsws).

Cov tshuaj tsis tau sim rau cov menyuam yaus, cov poj niam cev xeeb tub, thiab cov niam tu. Yog li ntawd, qhov pheej hmoo txaus ntshai rau cov neeg zoo li no tsis paub. Txij li thaum fenofibrate tuaj yeem nkag mus rau hauv tus menyuam thiab mis, nws tsis pom zoo kom siv nws thiaj li tsis ua mob rau tus menyuam.

Nrog rau kev ceev faj thiab nyob rau hauv kev saib xyuas ntawm tus kws kho mob, cov tshuaj yog siv rau hypothyroidism, lub raum pathologies, thiab ntxiv rau kev kho mob ntawm cov neeg laus thiab cov neeg haus cawv.

Kev qhia rau kev siv

Nws yog ib qho tseem ceeb uas yuav tsum tau fenofibrate kom raug. Qhov no yuav pab cov lus qhia rau kev siv, uas pom zoo:

1. Nqa cov ntsiav tshuaj sab hauv yam tsis ntxo nrog dej.
2. Cov tshuaj yog qaug ib zaug nyob rau ib hnub, sib txuas nrog nws cov khoom noj kom tsawg (yog li nws zoo dua nqus).
3. Qhov ntau npaum ntawm cov tshuaj rau ntau yam pathologies yog 145 mg rau ib hnub. Cov neeg mob rau cov neeg laus tsis tas yuav hloov kho ntxiv.

Fenofibrate yuav tsum tau coj mus ntev. Hauv qhov no, yuav tsum muaj kev noj haus hypocholesterol tshwj xeeb.

Tom qab qee lub sijhawm (li 3 lub hlis tom qab pib kho), tus neeg mob cov ntshav yuav tsum kuaj kom pom qhov zoo qhov ua tau zoo. Yog tias qhov no tsis tau pom, koj yuav tsum kho qhov tshuaj lossis hloov qhov kev kho mob.

Yeeb tshuaj sib cuam tshuam

Cov tshuaj muaj peev xwm siv tau ua ke nrog nrog deb ntawm txhua yam tshuaj. Nov yog qee qhov piv txwv ntawm nws qhov kev cuam tshuam nrog lwm cov tshuaj:

1. Nrog rau kev tswj hwm tib lub sij hawm nrog anticoagulants, lawv cov nyhuv yog txhim kho. Qhov no tuaj yeem ua rau los ntshav. Yog tias koj yuav tsum tau siv lawv tib lub sijhawm, ces kev noj tshuaj ntawm cov tshuaj anticoagulants yuav txo qis 3 zaug.
2. Fenofibrate nrog cyclosporine, thaum noj ua ke, provokes muaj kev tsis zoo hauv lub raum ua haujlwm.
3. Siv cov khoom haum nrog rau lwm cov fibrates ntau qhov kev pheej hmoo ntawm kev tsim kev puas tsuaj rau cov leeg nqaij.

Cov lus qhia tshwj xeeb

Nws yog ib qho tseem ceeb kom kawm cov lus qhia tshwj xeeb ua ntej siv cov tshuaj. Ntawm lawv yog:

1. Cov tshuaj yuav tsis ua haujlwm yog tias koj tsis tshem tawm cov kabmob uas ua rau kev nce siab hauv lipid nce siab.
2. Thaum noj cov tshuaj, koj yuav tsum ua raws cov zaub mov noj nrog cov roj tsawg kawg nkaus.
3. Qhov ua tau zoo ntawm kev kho tuaj yeem tau soj ntsuam los ntawm kev soj ntsuam ntshav rau cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, LDL, triglycerides.
4. Yog tias tus neeg mob tau noj tshuaj hormonal, ces koj yuav tsum paub yog tias qhov nce ntawm lipid qib tsis yog vim tshwm sim los ntawm kev tsis txaus ntseeg hormonal.
5. Hauv thawj lub xyoo ntawm kev noj tshuaj, nws raug nquahu kom soj ntsuam qib ntawm hepatic transaminases (ALT thiab AST).

Cov Qauv ALT thiab AST

Cov kev ntsuas zoo li no tuaj yeem txhim kho qhov muaj txiaj ntsig ntawm cov tshuaj, nrog rau kev tiv thaiv txoj kev txhim kho ntawm txoj kev xav tsis zoo thiab cov teeb meem.

Phiv, phiv ntau cov tsos mob

Cov tshuaj muaj cov kev mob tshwm sim txaus. Feem ntau lawv tshwm sim vim nws qhov kev siv tsis raug. Hauv qhov no, cov neeg mob yuav ntsib:

• teeb meem plab zom mov, uas tau pom los ntawm xeev ntuav, ntuav, pom plab, mob plab, mob plab zom mov,
• pancreatitis
• tsim pob zeb nyob hauv cov kua tsib lub raj,
• kev loj hlob ntawm kab mob siab (tshwm sim los ntawm daj ntseg, tawv nqaij khaus),
• spasm, leeg tsis muaj zog thiab mob,
• nce rau hauv cov qe ntshav dawb thiab hemoglobin,
• mob taub hau
• ua txhaum cai ntawm kev sib deev,
• thromboembolism, mob leukocytosis,
• mob raum tsis ua haujlwm
• cov txheej txheem mob hauv lub ntsws
• plaub hau poob
• kev ua xua rau ntawm daim tawv nqaij ntawm daim ntawv liab, khaus, tawm pob, ua pob zas,
• photophobia.

Overdose yog qhov tsawg kawg. Hauv qhov no, tus neeg mob yuav tsum coj mus rau hauv tsev kho mob. Lawv ua tawm kev kho cov tsos mob. Nws tsis tuaj yeem tshem tawm cov tshuaj nrog hemodialysis.

Zoo sib xws txhais tau tias

Fenofibrate hais txog cov neeg sawv cev hypoglycemic. Nws cov qauv analogues muaj cov khoom ua haujlwm zoo tib yam. Cov feem nrov ntawm lawv:

1. Tricor yog qhov siv nyiaj ntau, tab sis cov tshuaj muaj txiaj ntsig zoo los ntawm Fabkis.
2. Lipantil yog ib qho khoom lag luam hauv Fabkis uas muaj 200 mg fenofibrate hauv 1 ntsiav tshuaj.
3. Exlip yog lus Turkish tso tawm cov tshuaj muaj 250 mg ntawm fenofibrate.

Qee cov tshuaj muaj lwm yam khoom siv, tab sis muaj cov nyhuv zoo sib xws. Ntawm lawv yog:

1. Cov Atorvacor. Cov tshuaj muaj cov tshuaj nquag atorvastatin thiab yog ib qho inhibitor ntawm HMG-CoA reductase. Nws yog siv rau hyperlipidemia.
2. Livostor. Cov khoom lag luam tseem muaj cov atorvastatin. Nws yog ib cov tshuaj pheej yig rau txo cov ntshav roj.
3. Tulip. Nws yog tsim los ntawm lub tuam txhab tshuaj Sandoz hauv Poland. Atorvastatin ua raws li cov tshuaj nquag.

Cov nyiaj no yog siv rau kev tsis nkag siab rau fenofibrate. Teem ib lossis ib qho txuas ua yeeb yaj kiab tau rau tus kws kho mob uas tuaj koom xwb.

Kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob

Txhawm rau ntsuas qhov ua tau zoo ntawm cov tshuaj, nws yog ib qho tseem ceeb kom paub tias kws kho mob thiab lawv cov neeg mob hais dab tsi txog Fenofibrate. Nov yog qee qhov kev txheeb xyuas tiag:

Cov tshuaj Fenofibrate yog ib qho tshuaj zoo rau kev kho mob ntawm hyperlipidemia. Nws cov txiaj ntsig nyob hauv kev txuam nrog cov khoom nquag hauv cov ntshav, uas ua rau cov nyhuv ntev kawg - qhov txo qis hauv LDL thiab triglycerides.

Yuav ua li cas noj Fenofibrate

Cov ntsiav tshuaj tau noj yam tsis muaj kev zom. Cov neeg mob laus yuav tsum noj 145 mg ntawm ib hnub twg. Thaum hloov pauv los ntawm qhov ntau npaum ntawm 165, 180 mg rau qhov kev siv tshuaj txhua hnub ntawm 145 mg, yuav tsum tau kho qhov ntau ntxiv ntawm qhov kev niaj hnub tsis tas yuav tsum tau ua.

Cov tshuaj raug pom zoo kom noj ntev mus ntev tiv thaiv keeb kwm ntawm kev tsim kho kev noj haus zoo. Cov hauj lwm zoo ntawm kev kho yuav tsum raug soj ntsuam tas li los ntawm tus kws kho mob nyob ntawm seb cov ntshiab lipid cov ntsiab lus li cas.

Cov ntsiav tshuaj tau noj yam tsis muaj kev zom.

Nruab nrab hauv lub paj hlwb

Erectile kawg ua haujlwm thiab mob taub hau tuaj yeem tshwm sim nrog kev phiv tshuaj rau ntawm cov leeg hlwb.

Nrog rau kev siv tshuaj tsis yog, qhov tshwm sim tuaj yeem tshwm sim hauv daim ntawv chua leeg.
Nrog rau kev siv tshuaj tsis yog, qhov tshwm sim tshwm sim tuaj yeem tshwm sim hauv daim ntawv ntawm cov leeg mob.
Nrog rau kev siv tshuaj tsis yog, qhov tshwm sim tshwm sim tuaj yeem tshwm sim hauv daim ntawv ua pob rau ntawm daim tawv nqaij.
Nrog rau kev siv tshuaj tsis yog, qhov tshwm sim tshwm sim tuaj yeem tshwm sim hauv daim ntawv ntawm kev nce ntxiv hauv cov concentration ntawm cov qe ntshav dawb hauv cov ntshav.
Nrog rau txoj kev noj tshuaj tsis yog lawm, qhov tshwm sim tsis zoo nyob rau hauv daim ntawv ntawm raws plab yuav tshwm sim.
Nrog rau txoj kev noj tshuaj tsis yog, qhov tshwm sim yuav tshwm sim los ntawm kev ntuav.
Nrog rau kev siv tshuaj tsis yog lawm, ib sab phiv tuaj yeem tshwm sim hauv daim ntawv ntawm plaub hau ploj.

Los ntawm genitourinary system

Tsis muaj cov kev hloov pauv tsis zoo hauv qhov kev ua haujlwm ntawm lub chaw tso zis.

Feem ntau, ua pob rau ntawm daim tawv nqaij, ua kom lub ntsej muag (hnov tau lub teeb pom kev zoo), khaus lossis khaus ntawm qhov mob me mus rau mob hnyav tau tshwm sim. Muaj qee zaus, plaub hau ploj, qhov pom ntawm erythema, hlwv los yog nodules ntawm cov nqaij sib txuas hauv qab ntawm ultraviolet hluav taws xob tau pom.

Cuam tshuam rau lub peev xwm los tswj cov tshuab

Txais tos ntawm Fenofibrate tsis cuam tshuam rau kev xav, lub cev thiab lub hlwb tsis zoo, yog li ntawd, thaum lub sijhawm kho lipid-txo qis, tsav tsheb thiab ua haujlwm nrog cov khoom siv nyuaj tau tso cai.

Hauv lub sijhawm ntawm kev haus tshuaj, tsav tsheb thiab ua haujlwm nrog cov cuab yeej ua haujlwm nyuaj tau tso cai.

Siv thaum cev xeeb tub thiab lactation

Hauv kev tshawb fawb hauv cov tsiaj, tsis muaj teebmeem teratogenic pom. Hauv kev kawm ua ntej, mob toxic rau leej niam lub cev thiab kev pheej hmoo rau tus me nyuam hauv plab tau sau tseg, yog li ntawd, cov tshuaj tiv thaiv tsuas yog tias muaj txiaj ntsig zoo rau tus poj niam cev xeeb tub tshaj qhov kev pheej hmoo ntawm intrauterine anomalies hauv tus menyuam.

Kev pub mis niam thaum kev kho mob tso tseg.

Fenofibrate Tshaj Tawm rau Cov Menyuam

Cov tshuaj tsis pom zoo rau cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo vim tias tsis muaj ntaub ntawv qhia txog cov nyhuv ntawm Fenofibrate ntawm kev loj hlob thiab kev loj hlob ntawm lub cev.

Cov tshuaj tsis pom zoo rau cov menyuam yaus thiab cov hluas hauv qab 18 xyoo.
Kev pub niam mis thaum kho mob nrog rau cov tshuaj raug muab tso tseg.
Kev noj tshuaj thaum cev xeeb tub yog nqa tawm tsuas yog tias qhov txiaj ntsig zoo rau tus poj niam cev xeeb tub ntau dua qhov kev pheej hmoo ntawm cov leeg tsis zoo ntawm tus menyuam.

Noj ntau dhau

Muaj tsis muaj ib qho mob ntawm kev haus ntau dhau vim kev quav yeeb tshuaj. Nws tsis muaj qhov tshwj xeeb dab kev tub rog ua ke. Yog li, yog tias tus neeg mob noj nrog rau ib qho tshuaj rau ntau qhov pib yuav pib hnov ​​mob, ntxiv lossis ua rau muaj kev mob tshwm sim, nws yuav tsum nrhiav kev pab kho mob. Nrog tsev kho mob, cov tsos mob tshwm sim ntawm kev siv ntau dhau yog tshem tawm.

Kev cuam tshuam nrog lwm yam tshuaj

Thaum muab cov fenofibrate nrog cov tshuaj anticoagulants rau kev tswj hwm qhov ncauj, qhov ua tau zoo ntawm cov tshuaj hauv nqe lus nug nce ntxiv. Nrog rau kev cuam tshuam no, txoj kev pheej hmoo ntawm los ntshav ntau ntxiv vim kev hloov chaw ntawm cov tshuaj anticoagulant los ntawm cov ntshav protein.

Nrog rau kev siv hluav taws xob sib xyaw ua ke ntawm HMG-CoA reductase blockers, qhov kev pheej hmoo ntawm cov lus tshaj tawm tsis zoo rau cov nqaij pob txha nce, yog li yog tias tus neeg mob noj cov statins, nws yog ib qho tsim nyog yuav tsum thim cov tshuaj.

Cyclosporine pab txhawb kom lub raum ua kom tsis zoo rau lub raum, yog li thaum noj Fenofibrate, koj yuav tsum kuaj xyuas lub cev tas mus li. Yog tias tsim nyog, txoj kev tswj hwm ntawm cov tshuaj tiv thaiv hypolipidemic yog tso tseg.

Cawv tau zoo

Thaum kho nrog Fenofibrate, nws yog txwv tsis pub haus cawv. Kev haus dej cawv ethyl ua rau lub cev tsis muaj zog ntawm cov tshuaj, txhim kho cov nyhuv tshuaj lom rau lub siab ua haujlwm, lub hauv nruab nrab cov hlab ntsha thiab ntshav ntshav.

Analogues ntawm cov tshuaj suav nrog cov tshuaj nrog ib qho kev tsis sib xws ntawm kev txiav txim:

• Tricor
• Cov Atorvacor
• Tsaus ntuj
• Cyprofibrate,
• Ntsiav tshuaj Canon Fenofibrate,
• Livostor
• Dhau,
• Trilipix.

Hloov mus rau lwm cov tshuaj yog ua tiav tom qab sab laj kev kho mob.

Tricor kev qhia Lipantil 200 M kev qhia Phenofibrate CANON kev qhia

Cia rau cov mob rau cov tshuaj

Nws raug nquahu kom khaws cov tshuaj ntawm qhov kub txog + 25 ° C hauv qhov chaw qhuav, nyob deb ntawm tshav ntuj.

Nws raug nquahu kom khaws cov tshuaj ntawm qhov kub txog + 25 ° C hauv qhov chaw qhuav, nyob deb ntawm tshav ntuj.

Fenofibrate Xyuas

Muaj cov lus pom zoo los ntawm cov kws muag tshuaj thiab cov neeg mob.

Olga Zhikhareva, kws kho plawv, Moscow

Ua tau zoo nyob rau hauv kev sib ntaus tawm tsam siab triglycerides. Kuv pom zoo siv rau hom IIa, IIb, III thiab IV hyperlipoproteinemia. Hauv kev siv tshuaj, Kuv sau lub sijhawm tswj hwm thiab haus ntau npaum li cas ntawm ib tus neeg. Tsis muaj kev phiv pom. Nws tsis muaj suab hais txog kev txo cov roj (cholesterol).

Afanasy Prokhorov, neeg noj zaub mov zoo, Yekaterinburg

Nrog rau kev rog thiab cov roj (cholesterol) siab, fenofibroic acid pab zoo. Tshwj xeeb nrog qis qis ntawm kev tawm dag zog thiab kev noj haus. Thaum lub sijhawm kev kho mob, Kuv xav kom tso tseg cov kev coj ua tsis zoo thiab ua raws li kws kho mob cov lus pom zoo txhawm rau ua kom zoo ntxiv.

Nazar Dmitriev, 34 xyoo, Magnitogorsk

Kev kho mob zoo Lipids tau 5.4. Nrog kev siv Fenofibrate tsis tu ncua, cov theem ntawm cov rog tsawg dua rau 1,32. Ciaj ciam yog 1.7. Tsis muaj kev phiv sau tseg.

Anton Makaevsky, 29 xyoos, St. Petersburg

Nws tau siv li ib xyoos hloov Torvacard vim yog cov ntsiab lus tsawg ntawm HDL. Tom qab 4-5 lub hlis ntawm kev tswj hwm, kev tawm tsam ntawm xeev siab thiab mob ntawm lub plab mog tau pib tshwm sim. Tom qab 8-9 lub hlis, lawv tau ua kev phais mob tawm kom tshem tawm cov kem plab. Viscous bile thiab pob zeb xoob tau pom. Tom qab lub lag luam, kev tawm tsam nres.

Mikhail Taizhsky, 53 xyoo, Irkutsk

Cov tshuaj noj kom haus cov leeg ntsa txha khov, tab sis kuv tsis tuaj yeem hais txog qhov kev txiav txim. Cov hlab ntsha tsis muaj kev xav li cas. Nrog kev pabcuam ntawm cov tshuaj, lub cev hnyav poob vim tias kev tshaib plab, tab sis daim tawv nqaij sagged zoo heev. Yuav tsum tau ua haujlwm rov qab. Kuv txaus siab rau lub txiaj ntsig.